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Jessica E Galarraga, William J Frohna, Jesse M Pines
BACKGROUND: In 2014, the state of Maryland moved away from fee-for-service payments and into a global budget revenue (GBR) structure where hospitals have a fixed revenue target, independent of patient volume or services provided. We assess the effects of GBR adoption on emergency department (ED) admission decisions among adult encounters. METHODS: We used hospital medical record and billing data from adult ED encounters from January 1, 2011 through December 31, 2015, with four Maryland (MD) hospitals and two District of Columbia (DC) hospitals within the same health system...
June 22, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Narottam Saha, Alberto Rodriguez-Ramirez, Ai Duc Nguyen, Tara R Clark, Jian-Xin Zhao, Gregory E Webb
Extensive catchment modification since European settlement on the eastern coast of Australia results in poor coastal water quality, which poses a major threat for near shore coral communities in the iconic Great Barrier Reef (GBR). Long lived inshore corals have the potential to provide long-term temporal records of changing water quality both pre- and post-anthropogenic modification. However, water quality proxies require more study and validation of the robustness of coral-hosted geochemical proxies for a specific site is critical...
October 15, 2018: Science of the Total Environment
Oliver Blume, Michael Back, Teresa Born, Ralf Smeets, Ole Jung, Mike Barbeck
OBJECTIVE: The use of allogeneic bone grafts for alveolar ridge reconstruction has become an often-discussed alternative to augmentation procedures using autografts. Nevertheless, there still is a lack of literature concerning long-time experiences of allografts for alveolar ridge reconstruction. Especially the results of the use of allogeneic bone blocks for mandible reconstructions need to be further investigated. CLINICAL CONSIDERATIONS: In this case report, we present the use of customized allogenic bone blocks in Guided Bone Regeneration (GBR) procedures for severely deficient mandibulary bones, the implantation after a healing period of 5 month and the 24-month follow-up data...
June 19, 2018: Journal of Esthetic and Restorative Dentistry
Alessandro Mattiola, Dieter Bosshardt, Patrick R Schmidlin
Tooth extraction causes vertical and horizontal alveolar bone loss and consequent remodeling. Several methods have been introduced in terms of so-called “ridge preservation” techniques, which mostly resemble guided bone regenerative (GBR) procedures using filler materials and membranes in order to stabilize the respective sites. This conceptual case report describes a novel approach using a degradable polylactic acid membrane covered with a collagen matrix, which aims to reshape the resorbed alveolar wall and thereby to stabilize the soft tissues during matrix formation and socket mineralization...
June 17, 2018: Dentistry journal
Alexandra Garzon-Garcia, Joanne Burton, Hannah M Franklin, Philip W Moody, Robert W De Hayr, Michele A Burford
Sediments delivered to freshwater and marine environments can make important contributions to the aquatic bioavailable nutrient pool. In the Great Barrier Reef (GBR) catchments, particulate nutrients comprise an important fraction of the end of catchment loads; however, their contribution to the bioavailable nutrient pool is not well understood. This research determined which particulate nutrient parameters are the best indicators of the potential effect of fine sediment (<10 μm) on phytoplankton growth...
September 15, 2018: Science of the Total Environment
Maria B Asparuhova, Jordi Caballé-Serrano, Daniel Buser, Vivianne Chappuis
Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral (DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells...
June 12, 2018: International Journal of Oral Science
Vivianne Chappuis, Kamal Shahim, Ramona Buser, Edi Koller, Tim Joda, Mauricio Reyes, Daniel Buser
The purpose of this case series was to assess safety and feasibility of a novel resorbable collagen matrix (CMX) to enhance tissue thickness simultaneous with implant placement and guided bone regeneration (GBR) in esthetic sites over an 8-week healing period. Soft tissue thickness at implant sites and adjacent teeth was monitored with an ultrasonic device. Overall tissue contour changes were assessed by sequential digital surface model superimpositions. Periodontal parameters and patient-related outcomes revealed no significant changes...
July 2018: International Journal of Periodontics & Restorative Dentistry
Rebecca Bartley, Chris Thompson, Jacky Croke, Tim Pietsch, Brett Baker, Kate Hughes, Anne Kinsey-Henderson
Sediment runoff has been cited as a major contributor to the declining health of the Great Barrier Reef (GBR), however, climate and land use drivers have not been jointly evaluated. This study used alluvial archives from fluvial benches in two tributaries of the Upper Burdekin catchment together with the best available land use history and climate proxy records to provide insights into the timing of depositional events in this region over the past 500 years. This study suggests that mining and the increased runoff variability in the latter half of the nineteenth century are the likely sources of the original excess sediment that was used to build the bench features in these catchments...
June 2018: Marine Pollution Bulletin
Shyh-Yuan Lee, Sheng-Chien Wu, Hsuan Chen, Lo-Lin Tsai, Jy-Jiunn Tzeng, Chih-Hsin Lin, Yuan-Min Lin
The aim of this research is to synthesize polycaprolactone-based polyurethanes (PCL-based PUs) that can be further used for the fabrication of guided bone regeneration (GBR) membranes with higher tensile strength and elongation at break than collagen and PTFE membranes. The PCL-based PUs were prepared by the polymerization of polycaprolactone (PCL) diol with 1,6-hexamethylene diisocyanate (HDI) at different ratios using either polyethylene glycol (PEG) or ethylenediamine (EDA) as chain extenders. The chemical, mechanical, and thermal properties of the synthesized polymers were determined using NMR, FTIR, GPC, DSC, and tensile tester...
2018: BioMed Research International
Mathilde Fénelon, Olivier Chassande, Jérome Kalisky, Florelle Gindraux, Stéphanie Brun, Reine Bareille, Zoran Ivanovic, Jean-Christophe Fricain, Claudine Boiziau
Due to its biological properties, human amniotic membrane (hAM) is widely studied in the field of tissue engineering and regenerative medicine. hAM is already very attractive for wound healing and it may be helpful as a support for bone regeneration. However, few studies assessed its potential for guided bone regeneration (GBR). The purpose of the present study was to assess the potential of the hAM as a membrane for GBR. In vitro, cell viability in fresh and cryopreserved hAM was assessed. In vivo, we evaluated the impact of fresh versus cryopreserved hAM, using both the epithelial or the mesenchymal layer facing the defect, on bone regeneration in a critical calvarial bone defect in mice...
June 1, 2018: Journal of Materials Science. Materials in Medicine
Nikolaos Soldatos, Georgios E Romanos, Michelle Michaiel, Ali Sajadi, Nikola Angelov, Robin Weltman
Background: The placement of an implant in a previously infected site is an important etiologic factor contributing to implant failure. The aim of this case report is to present the management of retrograde peri-implantitis (RPI) in a first maxillary molar site, 2 years after the implant placement. The RPI was treated using an air-abrasive device, Er,Cr:YSGG laser, and guided bone regeneration (GBR). Case Description: A 65-year-old Caucasian male presented with a draining fistula associated with an implant at tooth #3...
2018: Case Reports in Dentistry
Xiu-Bao Kang, Hai Lu, Zhi-Guo Wang
Refractive index sensors based on the interrogation of guided Bloch surface wave resonance (GBR) in the azimuthal angle domain are studied both theoretically and numerically. The azimuthal sensitivity of the sensors is shown to be inversely proportional to the sines of both the azimuthal angle and the polar angle of the detecting electromagnetic signals. Extremely large azimuthal sensitivity is then achieved when the GBR sensor is designed to work near a small azimuthal angle and the polar angle is also fixed to a small one (For the azimuthal angle domain near φ = 5° and a fixed polar angle of θ = 5°, the azimuthal sensitivity gets larger than 5000 degrees per refractive index unit (Deg/RIU))...
May 14, 2018: Optics Express
Julie Vercelloni, Sam Clifford, M Julian Caley, Alan R Pearse, Ross Brown, Allan James, Bryce Christensen, Tomasz Bednarz, Ken Anthony, Manuel González-Rivero, Kerrie Mengersen, Erin E Peterson
Aesthetic value, or beauty, is important to the relationship between humans and natural environments and is, therefore, a fundamental socio-economic attribute of conservation alongside other ecosystem services. However, beauty is difficult to quantify and is not estimated well using traditional approaches to monitoring coral-reef aesthetics. To improve the estimation of ecosystem aesthetic values, we developed and implemented a novel framework used to quantify features of coral-reef aesthetics based on people's perceptions of beauty...
April 2018: Royal Society Open Science
Basel Elnayef, Cristina Porta, Fernando Suárez-López Del Amo, Lorenzo Mordini, Jordi Gargallo-Albiol, Federico Hernández-Alfaro
PURPOSE: Owing to volumetric changes after tooth extraction, lateral ridge augmentation has become a common procedure prior or simultaneous to implant placement. Nonetheless, little is known with regard to the dimensional remodeling after healing of these lateral ridge augmentation procedures. Hence, the purpose of this systematic review was to assess the stability of bone grafting material between augmentation procedures and final healing, in terms of resorption rate. MATERIALS AND METHODS: An electronic and hand literature search was conducted in several databases, such as the Cochrane Oral Health Group Trials Register, Embase, and Cochrane Central Register of Controlled Trials, up until February 2017...
May 2018: International Journal of Oral & Maxillofacial Implants
Zoe T Richards, Jon C Day
Background: The Great Barrier Reef (GBR) is the world's most iconic coral reef ecosystem, recognised internationally as a World Heritage Area of outstanding significance. Safeguarding the biodiversity of this universally important reef is a core legislative objective; however, ongoing cumulative impacts including widespread coral bleaching and other detrimental impacts have heightened conservation concerns for the future of the GBR. Methods: Here we review the literature to report on processes threatening species on the GBR, the status of marine biodiversity, and evaluate the extent of species-level monitoring and reporting...
2018: PeerJ
Seyedramin Pajoumshariati, Hadi Shirali, Seyedeh Kimia Yavari, Sogol Naghavi Sheikholeslami, Ghogha Lotfi, Fatemeh Mashhadi Abbas, Alireza Abbaspourrad
In periodontics, osteoconductive biodegradable guided bone regeneration (GBR) membranes with acceptable physico-mechanical properties are required to fix alveolar bone defects. The objectives of the present study were to produce and characterize a novel co-polyester-poly (butylene succinate-co-glycolate) (PBSGL), and fabricate a PBSGL membrane by electrospinning. We then aimed to evaluate the in vitro effect of the glycolate ratio on the biocompatibility and osteogenic differentiation of mesenchymal stem cells (MSCs), and evaluate in vivo bone regeneration using these membranes in rabbit calvarial defects by histology...
May 14, 2018: Scientific Reports
Yuzhu He, Yahui Jin, Xiumei Wang, Shenglian Yao, Yuanyuan Li, Qiong Wu, Guowu Ma, Fuzhai Cui, Huiying Liu
Guided bone regeneration (GBR) technique is widely used in the treatment of bone defects caused by peri-implantitis, periodontal disease, etc. However, the GBR membranes commonly used in clinical treatments currently have no antibacterial activity. Therefore, in this study, sequential layer-by-layer electrospinning and electrospraying techniques were utilized to prepare a gelatin (Gln) and chitosan (CS) composite GBR membrane containing hydroxyapatite nanoparticles (nHAp) and antimicrobial peptide (Pac-525)-loaded PLGA microspheres (AMP@PLGA-MS), which was supposed to have osteogenic and antibacterial activities...
May 14, 2018: Nanomaterials
D Stankovic, M Labudovic-Borovic, R Radosavljevic, M Marinkovic, E R Isenovic
Mucograft is collagen matrix was designed for use in open healing situations due to its compact outer layer. The technique presented in this article is an attempt to avail this attribute for covering open oral wound in guided bone regeneration (GBR) procedure. The essential idea of this technique is to avoid scoring of periosteum, submucosa and muscle layer for buccal flap advancement. Therefore, we used mucograft to cover bone substitute and barrier membrane in GBR surgical procedure. Thus, we avoided periostal-releasing incisions (PRI) and gained reposition of the flap to original level without impairing the attached keratinized gingiva...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Nicole Rosa de Freitas, Luísa Belluco Guerrini, Luis Augusto Esper, Michyele Cristhiane Sbrana, Gisele da Silva Dalben, Simone Soares, Ana Lúcia Pompéia Fraga de Almeida
The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M...
2018: Journal of Applied Oral Science: Revista FOB
Brian H Lee, Michael R Stallcup
The glucocorticoid receptor (GR) regulates genes in many physiological pathways by binding to enhancer and silencer elements of target genes, where it recruits coregulator proteins that remodel chromatin and regulate the assembly of transcription complexes. The coregulator Hydrogen peroxide-inducible clone 5 (Hic-5) is necessary for glucocorticoid (GC) regulation of one group of GR target genes, is irrelevant for a second group, and inhibits GR binding to a third gene set, thereby blocking their regulation by GC...
2018: PloS One
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