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https://www.readbyqxmd.com/read/29672529/potential-and-limits-for-rapid-genetic-adaptation-to-warming-in-a-great-barrier-reef-coral
#1
Mikhail V Matz, Eric A Treml, Galina V Aglyamova, Line K Bay
Can genetic adaptation in reef-building corals keep pace with the current rate of sea surface warming? Here we combine population genomics, biophysical modeling, and evolutionary simulations to predict future adaptation of the common coral Acropora millepora on the Great Barrier Reef (GBR). Genomics-derived migration rates were high (0.1-1% of immigrants per generation across half the latitudinal range of the GBR) and closely matched the biophysical model of larval dispersal. Both genetic and biophysical models indicated the prevalence of southward migration along the GBR that would facilitate the spread of heat-tolerant alleles to higher latitudes as the climate warms...
April 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29667574/genomic-non-coding-regions-reveal-hidden-patterns-of-mumps-virus-circulation-in-spain-2005-to-2015
#2
Ana M Gavilán, Aurora Fernández-García, Angel Rueda, Ana Castellanos, Josefa Masa-Calles, Noemí López-Perea, María V Torres de Mier, Fernando de Ory, Juan E Echevarría
BackgroundSince mumps vaccination was introduced in 1981 in Spain, the incidence of the disease has dropped significantly. However, cyclic epidemic waves and outbreaks still occur, despite high vaccination coverage. The World Health Organization (WHO) recommends genotyping to trace the pattern of mumps virus (MuV) circulation. Genotype H was predominant in Spain, but was replaced in 2005 by genotype G which has subsequently remained dominant. Of the small hydrophobic protein gene sequences, 78% are identical and belong to the MuVi/ Sheffield...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29662652/guided-bone-regeneration-using-a-bone-tissue-engineering-complex-consisting-of-a-poly-dl-lactide-membrane-and-bone-mesenchymal-stem-cells
#3
Dahui Wang, Yifeng Lin, Lian Chen, Yueqiang Mo, Peng Huang, Ruixue Ma
Developmental dysplasia of the hip (DDH) is one of the most common diseases encountered in pediatric orthopedic departments. Current treatment strategies seek to improve acetabular coverage, the principal defect of acetabular dysplasia, but are not very successful. We developed a guided bone regeneration (GBR) strategy to improve acetabular coverage via bone tissue engineering (BTE). Poly- dl -lactide (PDLLA) membranes were seeded with bone marrow mesenchymal stem cells (BMSCs) to form a BTE complex, which was then implanted into the superior margin of the acetabulum in a rabbit DDH model...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29660714/techno-environmental-assessment-of-the-green-biorefinery-concept-combining-process-simulation-and-life-cycle-assessment-at-an-early-design-stage
#4
Andrea Corona, Morten Ambye-Jensen, Giovanna Croxatto Vega, Michael Zwicky Hauschild, Morten Birkved
The Green biorefinery (GBR) is a biorefinery concept that converts fresh biomass into value-added products. The present study combines a Process Flowsheet Simulation (PFS) and Life Cycle Assessment (LCA) to evaluate the technical and environmental performance of different GBR configurations and the cascading utilization of the GBR output. The GBR configurations considered in this study, test alternatives in the three main steps of green-biorefining: fractionation, precipitation, and protein separation. The different cascade utilization alternatives analyse different options for press-pulp utilization, and the LCA results show that the environmental profile of the GBR is highly affected by the utilization of the press-pulp and thus by the choice of conventional product replaced by the press-pulp...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29656648/germinated-brown-rice-attenuates-atherosclerosis-and-vascular-inflammation-in-low-density-lipoprotein-receptor-knockout-mice
#5
Ruozhi Zhao, Nora Ghazzawi, Jiansu Wu, Khuong Le, Chunyang Li, Mohammed H Moghadasian, Yaw L Siow, Franklin Apea-Bah, Trust Beta, Zhengfeng Yin, Garry Shen
The present study investigated the effects of germinated brown rice (GBR) on atherosclerosis and underlying mechanism in low-density lipoprotein receptor-knockout (LDLr-KO) mice. The sizes of atherosclerotic lesions in aortic roots of LDLr-KO mice fed with diet supplemented with 60% GBR (weight/weight) were significantly less than that in mice fed with 60% of white rice (WR) or control diet (p<0.05) and all diets containing 0.06% cholesterol. WR or GBR diet did not significantly alter plasma total or LDL-cholesterol, fecal sterols, glucose or the activities of antioxidant enzymes compared to the control diet...
April 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29656495/randomized-controlled-clinical-study-assessing-two-membranes-for-guided-bone-regeneration-of-peri-implant-bone-defects-3-year-results
#6
Tobias Basler, Nadja Naenni, David Schneider, Christoph H F Hämmerle, Ronald E Jung, Daniel S Thoma
OBJECTIVES: To assess two- and three-dimensional changes of the peri-implant tissues as well as clinical, biological, and radiological outcomes of implants having been treated with resorbable or nonresorbable membranes at 3 years. MATERIALS AND METHODS: Twenty-three patients were re-examined after having received a single-tooth implant in the esthetic zone in conjunction with guided bone regeneration (GBR) using either a resorbable (RES) or a titanium-reinforced nonresorbable membrane (N-RES) and demineralized bovine bone mineral...
April 15, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29603876/development-of-asymmetric-resorbable-membranes-for-guided-bone-and-surrounding-tissue-regeneration
#7
C Fidalgo, M A Rodrigues, T Peixoto, J V Lobato, J D Santos, M A Lopes
Membranes design for guided tissue engineering have been studied to aid in cell viability and function as tissue barriers. Two asymmetric resorbable membranes for guided bone regeneration (GBR) were produced: chitosan/pectin/poly-caprolactone (PECm) and poly(vinyl alcohol)/polyethylenimine/poly(ethylene glycol) (PVAm). Both membranes were characterized by physical, chemical, mechanical, degradation rate, and in vitro biological assessment. Scanning electron microscopy (SEM) confirmed the membranes asymmetry, in which PECm asymmetry is given by roughness and chemical composition, while PVAm's only by differences in porosity...
March 31, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29579992/mild-high-hydrostatic-pressure-pretreatments-applied-before-soaking-process-to-modulate-wholegrain-brown-rice-germination-an-examination-on-embryo-growth-and-physicochemical-properties
#8
Qiang Xia, Yunfei Li
This investigation aimed to examine the effects of a novel processing pattern, combining high hydrostatic pressure (HHP) with germination, on the embryo growth and physicochemical characteristics of wholegrain brown rice (WBR). WBR grains were firstly subjected to mild HHP stress (30-90 MPa/5 min) and then incubated at 37 °C for 52 h for obtaining germinated samples (GBR). The results showed that HHP shock resulted in a delayed embryo growth of WBR grains, maintaining acceptable sprouting rates ranging from 65% to 76% when germination was finished...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29562760/maternal-interventions-to-improve-offspring-outcomes-in-rodent-models-of-diet-induced-obesity-a-review
#9
Daniela Menichini, Monica Longo, Fabio Facchinetti
Maternal obesity is an adverse factor that affects the intrauterine environment during critical periods of fetal developmental causing adverse lifelong effects on offspring health. Several different interventions have been performed in animal models of obesity to ameliorate maternal conditions and consequently reduce the adverse effects on offspring. Our aim was to critically review studies involving murine models of obesity induced by high fat diet (HFD), assessing maternal outcomes during pregnancy and the related offspring conditions...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29561754/integrated-oxidized-hyaluronic-acid-collagen-hydrogel-with-%C3%AE-tcp-using-proanthocyanidins-as-a-crosslinker-for-drug-delivery
#10
Yang Wei, Yu-Han Chang, Chung-Jui Liu, Ren-Jei Chung
The susceptibility of guided bone regeneration (GBR) material to infection by pathogens at wound sites during bone healing has often been overlooked. The objective of this study was the synthesis and characterization of a potential material for antibacterial GBR application. In the current study, the mechanical strength and biocompatibility of a composite restoration material-made of oxidized hyaluronic acid (HA)/type I collagen hydrogel integrated with tricalcium phosphate (β-TCP) using a natural crosslinking agent, oligomeric proanthocyanidins (OPCs)-were evaluated...
March 21, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29557403/one-stage-horizontal-guided-bone-regeneration-with-autologous-bone-anorganic-bovine-bone-and-collagen-membranes-follow-up-of-a-prospective-study-30-months-after-loading
#11
Silvio Mario Meloni, Sascha Alexander Jovanovic, Milena Pisano, Giacomo De Riu, Edoardo Baldoni, Marco Tallarico
PURPOSE: To present the medium-term results of one-stage guided bone regeneration (GBR) using autologous bone and anorganic bovine bone, placed in layers, in association with resorbable collagen membranes, for the reconstruction of horizontal bony defects. MATERIALS AND METHODS: This study was designed as an uncontrolled prospective study. Partially edentulous patients, having less than 6.0 mm and more than 4.0 mm of residual horizontal bone width were selected and consecutively treated with simultaneously implant installation and bone regeneration by using 2...
2018: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29534836/global-budget-revenue-on-a-single-institution-s-costs-and-outcomes-in-patients-undergoing-total-hip-arthroplasty
#12
Ronald E Delanois, Chukwuweike U Gwam, Jeffrey J Cherian, Jennifer I Etcheson, Nicole E George, Kathleen A Schneider, Michael A Mont
BACKGROUND: The state of Maryland was granted a waiver by the Center for Medicare and Medicaid Services to implement a Global Budget Revenue (GBR) reimbursement model. This study aims to compare (1) costs of inpatient hospital stays; (2) postacute care costs; (3) lengths of stay (LOS); and (4) discharge disposition who underwent primary total hip arthroplasty at a single Maryland-based orthopedic institution before and after the implementation of GBR. METHODS: The Maryland Center for Medicare and Medicaid Services database was queried to obtain all Medicare patients who underwent total hip arthroplasty at a single institution before and after the implementation of GBR...
February 15, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29529590/reinforced-chitosan-membranes-by-microspheres-for-guided-bone-regeneration
#13
Di Huang, Lulu Niu, Jian Li, Jingjing Du, Yan Wei, Yinchun Hu, Xiaojie Lian, Weiyi Chen, Kaiqun Wang
In order to improve the osteogenic activity and mechanical strength of the guided bone regeneration (GBR) membrane for repairing bone defect, nano-hydroxyapatite/chitosan (nHA/CS) composite microspheres were prepared through in situ biomimetic method, then composite microspheres were incorporated into CS membrane. The morphologies and mechanical properties of the composite membranes were investigated through scanning electronic microscopy (SEM) and universal mechanical testing machine. The results show that the in situ biomimetic nHA/CS microspheres were embedded in CS membrane and were integrated tightly with CS matrix...
March 7, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29510367/defining-wet-season-water-quality-target-concentrations-for-ecosystem-conservation-using-empirical-light-attenuation-models-a-case-study-in-the-great-barrier-reef-australia
#14
Caroline Petus, Michelle Devlin, Eduardo Teixera da Silva, Stephen Lewis, Jane Waterhouse, Amelia Wenger, Zoe Bainbridge, Dieter Tracey
Optically active water quality components (OAC) transported by flood plumes to nearshore marine environments affect light levels. The definition of minimum OAC concentrations that must be maintained to sustain sufficient light levels for conservation of light-dependant coastal ecosystems exposed to flood waters is necessary to guide management actions in adjacent catchments. In this study, a framework for defining OAC target concentrations using empirical light attenuation models is proposed and applied to the Wet Tropics region of the Great Barrier Reef (GBR) (Queensland, Australia)...
March 2, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29504816/guided-bone-regeneration-of-femoral-segmental-defects-using-equine-bone-graft-an-in-vivo-micro-computed-tomographic-study-in-rats
#15
Mohammed Awadh Binsalah, Sundar Ramalingam, Mohammed Alkindi, Nasser Nooh, Khalid Al-Hezaimi
BACKGROUND AND OBJECTIVES: Guided bone regeneration (GBR) is commonly used for osseous defect reconstruction. The objective of this study was to evaluate in real-time (in-vivo) the efficacy of equine bone graft for GBR in segmental critical-size defects (CSD) of the femur in a rat model. MATERIALS AND METHODS: Following ethical approval, 30 male Wistar-Albino rats (age 12-14 months/weight 450-500 grams) were included. Under general-anesthesia, a mid-diaphyseal segmental CSD (5 mm) was created in the femur and stabilized using titanium Miniplate(4 holes,1...
March 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29491375/methylphenidate-enhances-neuronal-differentiation-and-reduces-proliferation-concomitant-to-activation-of-wnt-signal-transduction-pathways
#16
Edna Grünblatt, Jasmin Bartl, Susanne Walitza
Methylphenidate (Ritalin) is the most commonly prescribed drug in the treatment of attention-deficit hyperactivity disorder. It is suggested that in vivo, methylphenidate treatment supports cortical maturation, however, the molecular and cellular mechanisms are not well understood. This study aimed to explore the potential effect of methylphenidate on cell proliferation and maturation in various cellular models, hypothesizing its interaction with the Wnt-signaling. The termination of cell proliferation concomitant to neuronal maturation following methylphenidate treatment was observed in all of the cell-models tested: murine neural stem-, rat PC12- and the human SH-SY5Y-cells...
March 1, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29491021/diagnostic-yield-of-laboratory-methods-and-value-of-viral-genotyping-during-an-outbreak-of-mumps-in-a-partially-vaccinated-population-in-british-columbia-canada
#17
Alexandra Nunn, Shazia Masud, Mel Krajden, Monika Naus, Agatha N Jassem
Mumps remains endemic in North America despite routine use of the measles, mumps, and rubella (MMR) vaccine. In 2016, an outbreak of mumps in British Columbia, Canada provided an opportunity to determine the diagnostic utility of laboratory testing methods. Specimens from patients with clinical mumps were tested for infection using a commercial enzyme-linked immunosorbent assay (ELISA) for antibody detection and an in-house reverse transcriptase (RT) PCR targeting viral fusion and small hydrophobic (SH) genes...
February 28, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29485658/the-osteoimmunomodulatory-property-of-a-barrier-collagen-membrane-and-its-manipulation-via-coating-nanometer-sized-bioactive-glass-to-improve-guided-bone-regeneration
#18
Zetao Chen, Lingling Chen, Runheng Liu, Yixiong Lin, Shoucheng Chen, Shifeier Lu, Zhengmei Lin, Zhuofan Chen, Chengtie Wu, Yin Xiao
A barrier membrane is a major component of guided bone regeneration (GBR), which is traditionally viewed as a physical barrier. Due to its "foreign body" nature, the implantation of a barrier membrane would inevitably modulate immune response and subsequently affect bone dynamics, which has long been neglected. To bridge this knowledge gap, we investigated the osteoimmunomodulatory effects of barrier collagen membranes. It is found that barrier collagen membranes elicit significant effects on modulating the osteoimmune response of macrophages, by upregulating the expression of pro-inflammatory cytokines (TNFα, IL-1β, IL-6, and IL-18) and osteogenic factors (BMP2/6, WNT10b, OSM)...
February 27, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29454007/destruction-of-noradrenergic-terminals-increases-dopamine-concentration-and-reduces-dopamine-metabolism-in-the-medial-prefrontal-cortex
#19
Rita Gálosi, Zoltán Petykó, Veronika Kállai, Attila Tóth, Tamás Ollmann, László Péczely, Anita Kovács, Beata Berta, László Lénárd
Effects of destroyed noradrenergic (NE) innervation in the medial prefrontal cortex (mPFC) were examined on dopamine (DA) content and metabolism. 6-hydroxy-DOPA (6-OHDOPA) or 6-hydroxy-dopamine (6-OHDA) in combination with a potent DA reuptake inhibitor GBR 12935 or 6-OHDA were injected bilaterally into the mPFC in separate groups of animals. In addition, GBR 12935 or vehicle was injected into the mPFC in two other groups of animals as control experiments. NE and DA concentrations from postmortem tissue of the mPFC were measured using HPLC with electrochemical detection...
February 14, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29446096/degradation-pattern-of-a-porcine-collagen-membrane-in-an-in-vivo-model-of-guided-bone-regeneration
#20
E Calciolari, F Ravanetti, A Strange, N Mardas, L Bozec, A Cacchioli, N Kostomitsopoulos, N Donos
BACKGROUND AND OBJECTIVE: Although collagen membranes have been clinically applied for guided tissue/bone regeneration for more than 30 years, their in vivo degradation pattern has never been fully clarified. A better understanding of the different stages of in vivo degradation of collagen membranes is extremely important, considering that the biology of bone regeneration requires the presence of a stable and cell/tissue-occlusive barrier during the healing stages in order to ensure a predictable result...
February 15, 2018: Journal of Periodontal Research
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