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https://www.readbyqxmd.com/read/29454007/destruction-of-noradrenergic-terminals-increases-dopamine-concentration-and-reduces-dopamine-metabolism-in-the-medial-prefrontal-cortex
#1
Rita Gálosi, Zoltán Petykó, Veronika Kállai, Attila Tóth, Tamás Ollmann, László Péczely, Anita Kovács, Beata Berta, László Lénárd
Effects of destroyed noradrenergic (NE) innervation in the medial prefrontal cortex (mPFC) were examined on dopamine (DA) content and metabolism. 6-hydroxy-DOPA (6-OHDOPA) or 6-hydroxy-dopamine (6-OHDA) in combination with a potent DA reuptake inhibitor GBR 12935 or 6-OHDA were injected bilaterally into the mPFC in separate groups of animals. In addition, GBR 12935 or vehicle was injected into the mPFC in two other groups of animals as control experiments. NE and DA concentrations from postmortem tissue of the mPFC were measured using HPLC with electrochemical detection...
February 14, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29446096/degradation-pattern-of-a-porcine-collagen-membrane-in-an-in-vivo-model-of-guided-bone-regeneration
#2
E Calciolari, F Ravanetti, A Strange, N Mardas, L Bozec, A Cacchioli, N Kostomitsopoulos, N Donos
BACKGROUND AND OBJECTIVE: Although collagen membranes have been clinically applied for guided tissue/bone regeneration for more than 30 years, their in vivo degradation pattern has never been fully clarified. A better understanding of the different stages of in vivo degradation of collagen membranes is extremely important, considering that the biology of bone regeneration requires the presence of a stable and cell/tissue-occlusive barrier during the healing stages in order to ensure a predictable result...
February 15, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29440901/guided-osteoporotic-bone-regeneration-with-composite-scaffolds-of-mineralized-ecm-heparin-membrane-loaded-with-bmp2-related-peptide
#3
Tingfang Sun, Man Liu, Sheng Yao, Yanhui Ji, Lei Shi, Kai Tang, Zekang Xiong, Fan Yang, Kaifang Chen, Xiaodong Guo
Introduction: At present, the treatment of osteoporotic defects poses a great challenge to clinicians, owing to the lower regeneration capacity of the osteoporotic bone as compared with the normal bone. The guided bone regeneration (GBR) technology provides a promising strategy to cure osteoporotic defects using bioactive membranes. The decellularized matrix from the small intestinal submucosa (SIS) has gained popularity for its natural microenvironment, which induces cell response. Materials and methods: In this study, we developed heparinized mineralized SIS loaded with bone morphogenetic protein 2 (BMP2)-related peptide P28 (mSIS/P28) as a novel GBR membrane for guided osteoporotic bone regeneration...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29429225/-development-of-a-novel-absorbable-nanofiber-chitosan-collagen-membrane-by-electrospinning-and-the-preliminary-study-on-guided-bone-regeneration
#4
B Gao, X J Li, M Lin, Y Y Li, Y Dong
Objective: To evaluate the application effect of nanofiber chitosan-collagen membrane (NCM) on guided bone regeneration (GBR). Methods: The mixture of collagen, chitosan, polyethylene oxide was used to make up the NCM by electrospinning, then the NCM was crosslinked by glutaraldehyde vapor. The physical property of the NCM was measured by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). MC3T3-E1 osteoblasts were cultured on NCM to characterize the biocompatibility. The effectiveness of four groups [contrast group, Bio-gide membrane (BGM), compressed chitosan-collagen menbrane (CCM), NCM/CCM] on bone regeneration were evaluated in critical-sized defects (diameter=5 mm) in SD rats...
February 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29429055/clinical-study-of-guided-bone-regeneration-with-resorbable-polylactide-co-glycolide-acid-membrane
#5
Takako Kawasaki, Seigo Ohba, Yuya Nakatani, Izumi Asahina
The guided bone regeneration (GBR) technique is often applied to provide sufficient bone for ideal implant placement. The objective of this study was to evaluate whether GC membrane®, which has already been used for guided tissue regeneration (GTR), can also be available for GBR. Twenty-three implants in 18 patients were evaluated in the study. All patients underwent implant placement with GBR using GC membrane®. Cone-beam computed tomography was performed at 13-30 weeks after surgery and the amount of augmented bone was assessed...
February 10, 2018: Odontology
https://www.readbyqxmd.com/read/29421855/l-prf-block-for-bone-augmentation-procedure-a-proof-of-concept-study
#6
Simone Cortellini, Ana B Castro, Andy Temmerman, Jeroen Vandessel, Nelson Pinto, Reinhilde Jacobs, Marc Quirynen
AIM: The objective of this proof-of-concept study was to investigate the effects of a new GBR technique with a tissue engineering approach. MATERIAL AND METHODS: This single cohort observational study evaluated the outcome of the L-PRF block for horizontal bone augmentation in the maxilla. The L-PRF block is prepared by mixing a particulated biomaterial with chopped L-PRF membranes at a 50:50 ratio and adding Liquid Fibrinogen to glue all together. Horizontal augmentation was assessed linearly and volumetrically immediately after surgery and 5-8 months later by matching consecutive CBCTs...
February 8, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29421125/the-need-for-a-formalised-system-of-quality-control-for-environmental-policy-science
#7
Piers Larcombe, Peter Ridd
Research science used to inform public policy decisions, herein defined as "Policy-Science", is rarely subjected to rigorous checking, testing and replication. Studies of biomedical and other sciences indicate that a considerable fraction of published peer-reviewed scientific literature, perhaps half, has significant flaws. To demonstrate the potential failings of the present approaches to scientific Quality Control (QC), we describe examples of science associated with perceived threats to the Great Barrier Reef (GBR), Australia...
January 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29420869/vulnerability-of-the-great-barrier-reef-to-climate-change-and-local-pressures
#8
Nicholas H Wolff, Peter J Mumby, Michelle Devlin, Kenneth R N Anthony
Australia's Great Barrier Reef (GBR) is under pressure from a suite of stressors including cyclones, crown-of-thorns starfish (COTS), nutrients from river run-off and warming events that drive mass coral bleaching. Two key questions are: how vulnerable will the GBR be to future environmental scenarios, and to what extent can local management actions lower vulnerability in the face of climate change? To address these questions, we use a simple empirical and mechanistic coral model to explore six scenarios that represent plausible combinations of climate change projections (from four Representative Concentration Pathways, RCPs), cyclones and local stressors...
February 8, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29414179/long-term-operation-with-an-insight-into-a-newly-established-green-bio-sorption-reactor-can-it-achieve-1%C3%A2-%C3%A2-1%C3%A2-%C3%A2-2
#9
Ranbin Liu, Yaqian Zhao, Tong Wang, Cheng Shen
An eco-friendly system of green bio-sorption reactor (GBR), constructed by embedding alum sludge-based constructed wetland (AlCW) into a conventional activated sludge process to achieve "1 + 1 > 2", was evaluated under a long-term operation basis. Insight into the pollutants removal, particularly the role of the AlCW in the GBR, was explored and discussed. The results showed that the GBR could achieve 90% and 95% removal for TN and TP (Stage 4), respectively, under the hydraulic and nitrogen loading rate of 2...
January 31, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29414147/clobenpropit-a-histamine-h3-receptor-antagonist-inverse-agonist-inhibits-3h-dopamine-uptake-by-human-neuroblastoma-sh-sy5y-cells-and-rat-brain-synaptosomes
#10
Elvia Mena-Avila, Ricardo Márquez-Gómez, Guillermo Aquino-Miranda, Gustavo Nieto-Alamilla, José-Antonio Arias-Montaño
BACKGROUND: Clobenpropit, a potent antagonist/inverse agonist at the histamine H3 receptor (H3R), reduced the cytotoxic action of 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells transfected with the human H3R. We therefore set out to study whether this effect involved a receptor-independent action on dopamine transport. METHODS: The uptake of [3H]-dopamine was assayed in SH-SY5Y cells and rat striatal or cerebro-cortical isolated nerve terminals (synaptosomes)...
August 30, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29407912/exploring-high-hydrostatic-pressure-mediated-germination-to-enhance-functionality-and-quality-attributes-of-wholegrain-brown-rice
#11
Qiang Xia, Liping Wang, Yunfei Li
This investigation aims to evaluate the effects of high hydrostatic pressure (HHP) applied prior to germination on functionality and quality of wholegrain-germinated brown rice (GBR). Wholegrain brown rice (WBR) were firstly stressed by HHP treatments (50-350 MPa/20 min), and then incubated at 37 °C to obtain GBR grains after a 2-day soaking period. Gama-aminobutyric acid contents significantly depended on the pressure applied, showing 25% increment in 50 MPa-stressed grains compared to the control...
May 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29407143/development-of-a-pcl-silica-nanoparticles-composite-membrane-for-guided-bone-regeneration
#12
Antonio G B Castro, Mani Diba, Monique Kersten, John A Jansen, Jeroen J J P van den Beucken, Fang Yang
The pivotal step in Guided Bone Regeneration (GBR) therapy is the insertion of a membrane for support and barrier functions. Here, we studied the effect of the addition of silica nanoparticles (Si-NPs) in electrospun poly(ε-caprolactone) (PCL) membranes to improve the mechanical and osteoconductive properties of the membranes. To this end, Si-NPs were firstly synthesized and then suspended in PCL solutions containing a polar solvent (2,2,2-trifluroethanol) and water with the addition of an anionic surfactant...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29397545/coral-reef-aerosol-emissions-in-response-to-irradiance-stress-in-the-great-barrier-reef-australia
#13
Roger Cropp, Albert Gabric, Dien van Tran, Graham Jones, Hilton Swan, Harry Butler
We investigate the correlation between stress-related compounds produced by corals of the Great Barrier Reef (GBR) and local atmospheric properties-an issue that goes to the core of the coral ecosystem's ability to survive climate change. We relate the variability in a satellite decadal time series of fine-mode aerosol optical depth (AOD) to a coral stress metric, formulated as a function of irradiance, water clarity, and tide, at Heron Island in the southern GBR. We found that AOD was correlated with the coral stress metric, and the correlation increased at low wind speeds, when horizontal advection of air masses was low and the production of non-biogenic aerosols was minimal...
February 3, 2018: Ambio
https://www.readbyqxmd.com/read/29389588/metabolite-profiling-antioxidant-and-%C3%AE-glucosidase-inhibitory-activities-of-germinated-rice-nuclear-magnetic-resonance-based-metabolomics-study
#14
Phaiwan Pramai, Nur Ashikin Abdul Hamid, Ahmed Mediani, Maulidiani Maulidiani, Faridah Abas, Sudarat Jiamyangyuen
In an attempt to profile the metabolites of three different varieties of germinated rice, specifically black (GBR), red, and white rice, a 1H-nuclear-magnetic-resonance-based metabolomics approach was conducted. Multivariate data analysis was applied to discriminate between the three different varieties using a partial least squares discriminant analysis (PLS-DA) model. The PLS model was used to evaluate the relationship between chemicals and biological activities of germinated rice. The PLS-DA score plot exhibited a noticeable separation between the three rice varieties into three clusters by PC1 and PC2...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29386810/bone-augmentation-as-an-adjunct-to-dental-implant-rehabilitation-in-patients-with-diabetes-mellitus-a-review-of-literature
#15
REVIEW
Komal Ladha, Ankit Sharma, Bhawana Tiwari, Dwaraka N Bukya
The aim of the present article is to review the success of bone augmentation performed as an adjunct to dental implant rehabilitation in patients with diabetes mellitus. A literature review was conducted in PubMed on this topic, which yielded a total of 102 publications. For inclusion, publications had to be human studies, written in English language and should report on the success of bone augmentation as an adjunct to dental implant rehabilitation in diabetic patients. After screening the titles and abstracts, 11 full texts publications were obtained, of which seven were included in the review...
July 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/29368353/effect-of-membrane-exposure-on-guided-bone-regeneration-a-systematic-review-and-meta-analysis
#16
REVIEW
Jeffrey Garcia, Austin Dodge, Paul Luepke, Hom-Lay Wang, Yvonne Kapila, Guo-Hao Lin
AIMS: This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri-implant sites and edentulous ridges. MATERIAL AND METHODS: Electronic and manual literature searches were conducted by two independent reviewers using four databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials, for articles up to February 2017. Articles were included if they were human clinical trials or case series reporting outcomes of GBR procedures with and without membrane exposure...
January 24, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29363620/biopolymer-based-membranes-associated-with-osteogenic-growth-peptide-for-guided-bone-regeneration
#17
Sybele Saska, Suzane Cristina Pigossi, Guilherme José Pimentel Lopes Oliveira, Lucas Teixeira, Marisa Capela, Andréa Gonçalves, Paulo Tambasco de Oliveira, Younes Messadeq, S J L Ribeiro, Reinaldo Marcheto, Ana Maria Minarelli Gaspar
Barrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with osteogenic growth peptide (OGP(10-14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological study was performed to evaluate the BC-COL OGP(10-14) membranes on bone healing after GBR in noncritical defects in rat femur...
January 24, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29345743/refining-mortality-estimates-in-shark-demographic-analyses-a-bayesian-inverse-matrix-approach
#18
Jonathan J Smart, André E Punt, William T White, Colin A Simpfendorfer
Leslie matrix models are an important analysis tool in conservation biology that are applied to a diversity of taxa. The standard approach estimates the finite rate of population growth (λ) from a set of vital rates. In some instances, an estimate of λ is available, but the vital rates are poorly understood and can be solved for using an inverse matrix approach. However, these approaches are rarely attempted due to pre-requisites of information on the structure of age or stage-classes. This study addressed this issue by using a combination of Monte Carlo simulations and the sample-importance-resampling (SIR) algorithm to solve the inverse matrix problem without data on population structure...
January 18, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29316410/environmental-warming-and-feminization-of-one-of-the-largest-sea-turtle-populations-in-the-world
#19
Michael P Jensen, Camryn D Allen, Tomoharu Eguchi, Ian P Bell, Erin L LaCasella, William A Hilton, Christine A M Hof, Peter H Dutton
Climate change affects species and ecosystems around the globe [1]. The impacts of rising temperature are particularly pertinent in species with temperature-dependent sex determination (TSD), where the sex of an individual is determined by incubation temperature during embryonic development [2]. In sea turtles, the proportion of female hatchlings increases with the incubation temperature. With average global temperature predicted to increase 2.6°C by 2100 [3], many sea turtle populations are in danger of high egg mortality and female-only offspring production...
January 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29303622/genotype-based-recall-to-study-metabolic-effects-of-genetic-variation-a-pilot-study-of-pparg-pro12ala-carriers
#20
Prasad G Kamble, Stefan Gustafsson, Maria J Pereira, Per Lundkvist, Naomi Cook, Lars Lind, Paul W Franks, Tove Fall, Jan W Eriksson, Erik Ingelsson
AIM: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of genotype-phenotype relationships. METHODS: We genotyped 2500 participants from the Swedish EpiHealth cohort and considered loss-of-function and missense variants in genes with relation to cardiometabolic traits as the basis for our GBR study. Therefore, we focused on carriers and non-carriers of the PPARG Pro12Ala (rs1801282) variant, as it is a relatively common variant with a minor allele frequency (MAF) of 0...
January 5, 2018: Upsala Journal of Medical Sciences
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