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https://www.readbyqxmd.com/read/28109299/in-utero-exposure-to-germinated-brown-rice-and-its-oryzanol-rich-extract-attenuated-high-fat-diet-induced-insulin-resistance-in-f1-generation-of-rats
#1
Hadiza Altine Adamu, Mustapha Umar Imam, Der-Jiun Ooi, Norhaizan Mohd Esa, Rozita Rosli, Maznah Ismail
BACKGROUND: The development of insulin resistance is multifactorial, with maternal pre- and postnatal nutrition having significant influences. In this regard, high fat diet (HFD) feeding in pregnancy has been shown to increase risks of metabolic diseases. Thus, we investigated the effects of supplementation of HFD with germinated brown rice (GBR) and GBR-derived gamma oryzanol-rich extract (OE) on insulin resistance and its epigenetic implications in pregnant rats and their offsprings...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28067045/neurotoxicity-of-%C3%AE-keto-amphetamines-deathly-mechanisms-elicited-by-methylone-and-mdpv-in-human-dopaminergic-sh-sy5y-cells
#2
Maria Joao Valente, Maria Lourdes Bastos, Eduarda Fernandes, Félix Carvalho, Paola Guedes de Pinho, Marcia Carvalho
Synthetic cathinones (β-keto amphetamines) act as potent CNS stimulants similarly to classical amphetamines, which raise concerns about their potential neurotoxic effects. The present in vitro study aimed to explore and compare the mechanisms underlying the neurotoxicity of two commonly abused cathinone derivatives, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxypyrovalerone (MDPV), with those of 3,4-methylenedioxymethamphetamine (MDMA), using undifferentiated and differentiated SH-SY5Y cells...
January 9, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28062250/autotransplantation-of-third-molars-with-completely-formed-roots-into-surgically-created-sockets-and-fresh-extraction-sockets-a-10-year-comparative-study
#3
H J Yu, P Jia, Z Lv, L X Qiu
The aim of this study was to analyze and compare the long-term clinical outcomes of mature third molar autotransplantation in surgically created sockets and fresh extraction sockets with regard to survival and functional success rates. A total of 65 third molars with completely formed roots were autotransplanted in 60 patients (average age 33.1 years). Thirty-six of the teeth were autotransplanted into surgically created sockets with or without guided bone regeneration (GBR; delayed autotransplantation), while 29 were autotransplanted into fresh extraction sockets (immediate autotransplantation; control group)...
January 3, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28054383/comparison-between-two-antimicrobial-protocols-with-or-without-guided-bone-regeneration-in-the-treatment-of-peri-implantitis-a-histomorphometric-study-in-dogs
#4
Umberto Demoner Ramos, Flavia Adelino Suaid, Ulf M E Wikesjö, Cristiano Susin, Mario Taba, Arthur Belém Novaes
OBJECTIVES: This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) in the surgical reconstruction of peri-implantitis defects. MATERIAL AND METHODS: Eight beagle dogs subject to ligature-induced peri-implantitis were used. The animals either received antimicrobial photodynamic therapy or topical tetracycline hydrochloride combined with GBR or as stand-alone surgical interventions. Block biopsies of the defect sites for histological analysis were obtained at euthanasia, 12 weeks postsurgery...
January 5, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28053048/identifying-new-antiepileptic-drugs-through-genomics-based-drug-repurposing
#5
Nasir Mirza, Greame J Sills, Munir Pirmohamed, Anthony G Marson
Currently available antiepileptic drugs (AEDs) fail to control seizures in 30% of patients. Genomics-based drug repurposing (GBR) offers the potential of savings in the time and cost of developing new AEDs. In the current study, we used published data and software to identify the transcriptomic signature of chornic temporal lobe epilepsy and the drugs that reverse it. After filtering out compounds based on exclusion criteria, such as toxicity, 36 drugs were retained. 11 of the 36 drugs identified (>30%) have published evidence of antiepileptic efficacy (for example, curcumin) or antiepileptogenic affect (for example, atorvastatin) in recognised rodent models or patients...
January 4, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28042445/guided-bone-regeneration-via-a-preformed-titanium-foil-clinical-histological-and-histomorphometric-outcome-of-a-case-series
#6
M Andreasi Bassi, C Andrisani, S Lico, Z Ormanier, L Ottria, M Gargari
PURPOSE: The aim of this paper was to evaluate the histological and histomorphometric outcome of Preformed Titanium Foil (PTF) to perform Guided Bone Regeneration (GBR) in posterior mandibular atrophies. MATERIALS AND METHODS: 10 subjects (1 male; 9 females; mean age 58±11.37 years), with distal mandibular atrophies were selected to perform GBR by means of PTF, using a moldable allograft paste as graft material. The devices, made of a 0,2 mm thick pure titanium foil, were pre-shaped using stereolithographic models obtained from CT-scan of the patients' recipient site...
October 2016: Oral & Implantology
https://www.readbyqxmd.com/read/28042439/full-arch-rehabilitation-in-severe-maxillary-atrophy-with-palatal-approach-implant-placement-a-case-report
#7
M Andreasi Bassi, M A Lopez, C Andrisani, Z Ormanier, M Gargari
PURPOSE: The edentulous severely atrophic maxilla, as consequence of alveolar bone resorption and pneumatisation of the maxillary sinus, represents a serious limitation to the implant rehabilitation. Implants insertion via palatal approach (PA), in combination with relatively minimally invasive techniques aimed at increasing bone volume without the use of autologous bone harvesting is a valid alternative among the options for the rehabilitation of the upper jaw. CLINICAL CASE: In a 70-year-old female, with a severe maxillary atrophy, 6 spiral taper implants were placed with the PA, combined with the bilateral transcrestal elevation of both the sinus floors and nasal cavities; a further GBR, with resorbable pericardium membrane covering a termoplastic allograft associated to a xenograft, was performed...
July 2016: Oral & Implantology
https://www.readbyqxmd.com/read/28006788/benthic-foraminifera-from-the-capricorn-group-great-barrier-reef-australia
#8
Briony L Mamo
Effective reef management and monitoring has become increasingly important as anthropogenic processes impact upon natural ecosystems. One locality that is under direct threat due to human activities is the Australian Great Barrier Reef (GBR). Marine foraminifera represent an abundant and readily applicable tool that can be used in reef studies to investigate a variety of ecological parameters and assist in understanding reef dynamics and influence management protocols. The first step is to establish a baseline knowledge of taxonomic composition within the region to facilitate comparative studies and monitor how assemblages change in order to maximise effective management...
December 23, 2016: Zootaxa
https://www.readbyqxmd.com/read/27998736/clinical-and-3-dimensional-radiographic-evaluation-of-autogenous-iliac-block-bone-grafting-and-guided-bone-regeneration-in-patients-with-atrophic-maxilla
#9
B Alper Gultekin, Erol Cansiz, M Oguz Borahan
PURPOSE: To evaluate the rate of graft resorption in autogenous iliac bone grafting (IBG) and guided bone regeneration (GBR) in patients with atrophic maxillae. MATERIALS AND METHODS: We performed a retrospective study involving patients requiring implant placement who underwent IBG or GBR. Volumetric changes of the graft sites were evaluated by imaging studies. The primary predictor and outcome variables were augmentation technique and rate of volumetric resorption, respectively...
November 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27978603/clinical-and-radiographic-intra-subject-comparison-of-implants-placed-with-or-without-guided-bone-regeneration-15-year-results
#10
Goran I Benic, Mira Bernasconi, Ronald E Jung, Christoph H F Hämmerle
AIM: To test whether implants placed with simultaneous guided bone regeneration (GBR) differ from implants placed without GBR regarding survival rate, interproximal marginal bone level (MBL), and dimensions of buccal bone and mucosa. MATERIAL & METHODS: Twenty-three patients treated 15 years earlier were included. Machined implants had been inserted following one of the two procedures: (1) with simultaneous GBR, which involved grafting with particulate deproteinized bovine bone mineral (DBBM), autogenous bone (AB) or a mixture of the two and defect covering with a native collagen membrane (CM), (GBR group) and (2) standard implant placement without GBR (control group)...
December 15, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27936590/brominated-graphene-as-mimetic-peroxidase-for-sulphide-ion-recognition
#11
Shikha Singh, Kheyanath Mitra, Aparna Shukla, Rajshree Singh, Ravi Kumar Gundampati, Nira Misra, Pralay Maiti, Biswajit Ray
Brominated graphene (GBR) having ~ 3% bromine content has shown novel peroxidase mimetic activity towards 3,3/,5,5/-tetramethylbenzidine (TMB) in the presence of H2O2. Optimum activity has been observed at pH 4.48 and after minimum ~ 30 min of equilibration time. Out of different analytes studied using the sensor combining TMB, H2O2 and GBR in phosphate buffer of pH 4.48, S-2 ion has effectively showed short duration of sensing (~ 2 min) within the detection range of 0.04 - 1 mM. A calibration curve for S-2 ion estimation has been constructed with the experimental linearity in 0...
December 12, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27926573/further-delineation-between-typical-and-atypical-dopamine-uptake-inhibitors-effects-on-food-maintained-behavior-and-food-consumption
#12
Jonathan M Slezak, Rajeev I Desai, Jonathan L Katz
The present studies compared the acute effects of benztropine analogs (4-Cl-BZT, JHW 007, AHN 1-055), which are atypical dopamine uptake inhibitors, with those of the standard dopamine uptake inhibitors GBR 12909 and cocaine, on the reinforcing efficacy of food and food intake in male Sprague-Dawley rats. Repeated drug effects of JHW 007 on food intake were also determined. The number of ratios completed under a progressive-ratio schedule of food delivery was used as an index of reinforcing efficacy. Food intake was determined by measuring powdered laboratory-chow consumption during daily 40 min food-availability time periods...
February 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27893512/flap-designs-for-flap-advancement-during-implant-therapy-a-systematic-review
#13
Alexandra B Plonka, Rachel A Sheridan, Hom-Lay Wang
PURPOSE: Guided bone regeneration (GBR) procedures allow ridge augmentation before or at time of implant placement. GBR outcomes rely on primary passive tension-free wound closure, which may be achieved by a variety of flap designs and surgical procedures. A comprehensive literature review of flap design and management is provided, including material types, incision design, reflection, releasing, and suturing techniques. MATERIALS AND METHODS: Two reviewers completed a literature search using the PubMed database and a manual search of relevant journals...
November 23, 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27886175/statistical-power-considerations-in-genotype-based-recall-randomized-controlled-trials
#14
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R Pearson, Ashfaq Ali, Paul W Franks
Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and allele frequencies reported in the DPP for the rs8065082 SLC47A1 variant, a metformin transported encoding locus...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847815/comparison-of-bone-resorption-rates-after-intraoral-block-bone-and-guided-bone-regeneration-augmentation-for-the-reconstruction-of-horizontally-deficient-maxillary-alveolar-ridges
#15
B Alper Gultekin, Elcin Bedeloglu, T Emre Kose, Eitan Mijiritsky
Purpose. Bone atrophy after tooth loss may leave insufficient bone for implant placement. We compared volumetric changes after autogenous ramus block bone grafting (RBG) or guided bone regeneration (GBR) in horizontally deficient maxilla before implant placement. Materials and Methods. In this retrospective study, volumetric changes at RBG or GBR graft sites were evaluated using cone-beam computed tomography. The primary outcome variable was the volumetric resorption rate. Secondary outcomes were bone gain, graft success, and implant insertion torque...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27844503/attentional-capture-by-physically-salient-stimuli-in-the-gamma-frequency-is-associated-with-schizophrenia-symptoms
#16
Laura Kornmayer, Gregor Leicht, Christoph Mulert
OBJECTIVES: Aberrant salience mainly is attributed to excessive dopaminergic processing in the ventral striatum. Increased gamma power during sensory processing of physical salience has been shown to be associated with positive trait schizotypy. In the present study, this is assessed in patients with schizophrenia. METHODS: The early evoked visual gamma-band response (GBR) at 40 Hz was assessed for a schizophrenia patient group (N = 22) and a matched healthy control group (N = 22) applying EEG time-frequency analysis...
December 23, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27834419/limitations-and-options-using-resorbable-versus-nonresorbable-membranes-for-successful-guided-bone-regeneration
#17
Nikolaos K Soldatos, Popi Stylianou, Vasiliki P Koidou, Nikola Angelov, Raymond Yukna, Georgios E Romanos
OBJECTIVE: Deficient bony ridges often complicate the implant treatment plan. Several treatment modalities are used to regenerate bone, including guided bone regeneration (GBR). The purpose of this study was to summarize the knowledge on different types of membranes available and currently used in GBR procedures in a staged approach or with simultaneous implant placement. The primary role of the membranes is to exclude epithelial and connective tissue cells from the wound area to be regenerated, and to create and maintain the space into which pluripotential and osteogenic cells are free to migrate...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27809393/global-warming-may-disproportionately-affect-larger-adults-in-a-predatory-coral-reef-fish
#18
Vanessa Messmer, Morgan S Pratchett, Andrew S Hoey, Andrew J Tobin, Darren J Coker, Steven J Cooke, Timothy D Clark
Global warming is expected to reduce body sizes of ectothermic animals. Although the underlying mechanisms of size reductions remain poorly understood, effects appear stronger at latitudinal extremes (poles and tropics) and in aquatic rather than terrestrial systems. To shed light on this phenomenon, we examined the size dependence of critical thermal maxima (CTmax) and aerobic metabolism in a commercially important tropical reef fish, the leopard coral grouper (Plectropomus leopardus) following acclimation to current-day (28...
November 3, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27806103/degradation-of-herbicides-in-the-tropical-marine-environment-influence-of-light-and-sediment
#19
Philip Mercurio, Jochen F Mueller, Geoff Eaglesham, Jake O'Brien, Florita Flores, Andrew P Negri
Widespread contamination of nearshore marine systems, including the Great Barrier Reef (GBR) lagoon, with agricultural herbicides has long been recognised. The fate of these contaminants in the marine environment is poorly understood but the detection of photosystem II (PSII) herbicides in the GBR year-round suggests very slow degradation rates. Here, we evaluated the persistence of a range of commonly detected herbicides in marine water under field-relevant concentrations and conditions. Twelve-month degradation experiments were conducted in large open tanks, under different light scenarios and in the presence and absence of natural sediments...
2016: PloS One
https://www.readbyqxmd.com/read/27775206/an-improved-method-for-calculating-toxicity-based-pollutant-loads-part-2-application-to-contaminants-discharged-to-the-great-barrier-reef-queensland-australia
#20
Rachael A Smith, Michael St J Warne, Kerrie Mengersen, Ryan Dr Turner
Pollutant loads are widely used to set pollution reduction targets and assess regulatory compliance for the protection of receiving waterbodies. However, when a pollutant load consists of a mixture of chemicals, reducing the overall load (mass) will not necessarily reduce the toxicity by a similar amount. This can be overcome by setting targets based on toxicity-based loads (toxic loads, TLs), where the load is modified according to the relative toxicity (expressed as toxic equivalency factors [TEFs]) of each toxicant...
October 24, 2016: Integrated Environmental Assessment and Management
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