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JOURNAL ARTICLE
Marine Lallemant, Andres Arteaga Shimojyo, Olivier Mayeur, Rajeev Ramanah, Chrystèle Rubod, Yohan Kerbage, Michel Cosson
INTRODUCTION AND HYPOTHESIS: In order to improve the knowledge POP physiopathology and POP repair, a generic biomechanical model of the female pelvic system has been developed. In the literature, no study has currently evaluated apical prolapse repair by posterior sacrospinous ligament fixation using a generic model nor a patient-specific model that personalize the management of POP and predict surgical outcomes based on the patient's pre-operative Magnetic Resonance Imaging. The aim of our study was to analyze the influence of a right and/or left sacrospinous ligament fixation and the distance between the anchorage area and the ischial spine on the pelvic organ mobility using a generic and a patient-specific Finite Element model (FEM) of the female pelvic system during posterior sacrospinous ligament fixation (SSF)...
2024: PloS One
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JOURNAL ARTICLE
F Hinojosa-Ramirez, L Tallon-Aguilar, J Tinoco-Gonzalez, A Sanchez-Arteaga, F Aguilar-Del Castillo, I Alarcon-Del Agua, S Morales-Conde
INTRODUCTION: There has been a rapid proliferation of the robotic approach to inguinal hernia, mainly in the United States, as it has shown similar outcomes to the laparoscopic approach but with a significant increase in associated costs. Our objective is to conduct a cost analysis in our setting (Spanish National Health System). MATERIALS AND METHODS: A retrospective single-center comparative study on inguinal hernia repair using a robotic approach versus laparoscopic approach...
March 20, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
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JOURNAL ARTICLE
Víctor De la Peña-Arteaga, Marta Cano, Daniel Porta-Casteràs, Muriel Vicent-Gil, Neus Miquel-Giner, Ignacio Martínez-Zalacaín, Lorea Mar-Barrutia, Marina López-Solà, Jessica R Andrews-Hanna, Carles Soriano-Mas, Pino Alonso, Maria Serra-Blasco, Clara López-Solà, Narcís Cardoner
Mindfulness-based cognitive therapy (MBCT) stands out as a promising augmentation psychological therapy for patients with obsessive-compulsive disorder (OCD). To identify potential predictive and response biomarkers, this study examines the relationship between clinical domains and resting-state network connectivity in OCD patients undergoing a 3-month MBCT programme. Twelve OCD patients underwent two resting-state functional magnetic resonance imaging sessions at baseline and after the MBCT programme. We assessed four clinical domains: positive affect, negative affect, anxiety sensitivity, and rumination...
March 18, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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JOURNAL ARTICLE
Genoveva BustosRivera-Bahena, A M Ramírez-Arteaga, Hugo A Saldarriaga-Noreña, A K Larios-Gálvez, José G González-Rodríguez, M Romero-Aguilar, Roy López Sesenes
The hexane extract of Persea schiedeana Ness (PSN) was analyzed as corrosion inhibitor for the brass surface immersed in 0.5 M HCl. Fourier-transform infrared spectroscopy and a gas chromatographic (GC) and mass spectrometric (MS) were used to identify the PSN extract's functional groups and compound constituents. The functional groups identified were <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>CH</mml:mtext> <mml:mn>3</mml:mn></mml:msub> </mml:math> and <mml:math xmlns:mml="https://www...
March 18, 2024: Scientific Reports
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JOURNAL ARTICLE
Víctor De la Peña-Arteaga, Pamela Chavarría-Elizondo, Asier Juaneda-Seguí, Ignacio Martínez-Zalacaín, Pedro Morgado, José Manuel Menchón, Maria Picó-Pérez, Miquel A Fullana, Carles Soriano-Mas
Trait anxiety is a well-established risk factor for anxiety and depressive disorders, yet its neural correlates are not clearly understood. In this study, we investigated the neural correlates of trait anxiety in a large sample (n = 179) of individuals who completed the trait and state versions of the State-Trait Anxiety Inventory and underwent resting-state functional magnetic resonance imaging. We used independent component analysis to characterize individual resting-state networks (RSNs), and multiple regression analyses to assess the relationship between trait anxiety and intrinsic connectivity...
March 15, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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JOURNAL ARTICLE
Chang-Ching Lin, Tsung-Cheng Chang, Yunguan Wang, Lei Guo, Yunpeng Gao, Emmanuel Bikorimana, Andrew Lemoff, Yisheng V Fang, He Zhang, Yanfeng Zhang, Dan Ye, Isabel Soria-Bretones, Alberto Servetto, Kyung-Min Lee, Xuemei Luo, Joseph J Otto, Hiroaki Akamatsu, Fabiana Napolitano, Ram Mani, David W Cescon, Lin Xu, Yang Xie, Joshua T Mendell, Ariella B Hanker, Carlos L Arteaga
CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss-of-function alterations confer resistance to CDK4/6i, but the optimal therapy for these patients is unclear. Through a genome-wide CRISPR screen, we identify protein arginine methyltransferase 5 (PRMT5) as a molecular vulnerability in ER+/RB1-knockout breast cancer cells. Inhibition of PRMT5 blocks the G1-to-S transition in the cell cycle independent of RB, leading to growth arrest in RB1-knockout cells...
March 13, 2024: Nature Communications
#27
JOURNAL ARTICLE
E Lizasoain-Arteaga, A Sáez-de-Guinoa, M M Parascanu, M Isasa
Bio-based products are a fast-growing market due to increasing consumer consciousness for sustainability. Although this is per se a positive trend, it leads to a higher demand for organic feedstocks which normally comes from primary agricultural sources and can lead to undesired deforestation or other land use changes to farmland. At the same time, Europe is facing another challenge related with the treatment of organic wastes. In this context, the project CAFIPLA developed an integrated process to convert heterogeneous organic materials to building blocks for the bio-based economy...
March 12, 2024: Waste Management
#28
JOURNAL ARTICLE
Nydia Balderas-Arteaga, Kenia Mendez, Alejandra Gonzalez-Rocha, Selene Pacheco-Miranda, Anabelle Bonvecchio, Edgar Denova-Gutiérrez
Childhood obesity is a major public health challenge. Previous research has identified the impact of school-based interventions for preventing and treating obesity; we hypothesized that when curricular changes are integrated, results could be exponentiated. This study aimed to systematically review and conduct a meta-analysis of the published literature analyzing information about school-based interventions inserted in the curriculum. The Cochrane Handbook methodology was followed. An electronic search was conducted in five databases, with a specific design strategy per database...
April 1, 2024: Health Promotion International
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JOURNAL ARTICLE
Norberto Guelbert, Oscar Mauricio Espitia Segura, Carolina Amoretti, Angélica Arteaga Arteaga, Nora Graciela Atanacio, Sabrina Bazan Natacha, Ellaine Doris Fernandes Carvalho, Maria Denise Fernandes Carvalho de Andrade, Inés María Denzler, Consuelo Durand, Erlane Ribeiro, Juan Carlos Giugni, Gabriel González, Dolores González Moron, Guillermo Guelbert, Zulma Janneth Hernández Rodriguez, Katiane Embiruçu Emilia, Marcelo Andrés Kauffman, Nury Isabel Mancilla, Laureano Marcon, Alessandra Marques Pereira, Carolina Fischinger Moura de Souza, Victor Adrián Muñoz, Ricardo Andrés Naranjo Flórez, André Luiz Pessoa, María Victoria Ruiz, Martha Luz Solano Villareal, Norma Spécola, Lina Marcela Tavera, Javiera Tello, Mónica Troncoso Schifferli, Sonia Ugrina, María Magdalena Vaccarezza, Diane Vergara, María Mercedes Villanueva
INTRODUCTION: Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), is a neurodegenerative autosomal recessive disease caused by TPP1 gene variants , with a spectrum of classic and atypical phenotypes. The aim of treatment is to slow functional decline as early as possible in an attempt to improve quality of life and survival. This study describes the clinical characteristics as well as the response to treatment with cerliponase alfa. MATERIALS AND METHODS: A retrospective study was conducted in five Latin-American countries, using clinical records from patients with CLN2...
March 2024: Molecular Genetics and Metabolism Reports
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JOURNAL ARTICLE
Ana Arteaga, Trevor Arino, Guy C Moore, Jenna L Bustos, Matthew K Horton, Kristin A Persson, Jun Li, William F Stickle, Tsuyoshi A Kohlgruber, Robert G Surbella, May Nyman
Spectator ions have known and emerging roles in aqueous metal-cation chemistry, respectively directing solubility, speciation, and reactivity. Here, we isolate and structurally characterize the last two metastable members of the alkali uranyl triperoxide series, the Rb+ and Cs+ salts (Cs-U1 and Rb-U1). We document their rapid solution polymerization via small-angle X-ray scattering, which is compared to the more stable Li+, Na+ and K+ analogues. To understand the role of the alkalis, we also quantify alkali-hydroxide promoted peroxide deprotonation and decomposition, which generally exhibits increasing reactivity with increasing alkali size...
March 11, 2024: Chemistry: a European Journal
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JOURNAL ARTICLE
Beatriz Arteaga-Pitzenbauer
No abstract text is available yet for this article.
March 2024: Journal of Refractive Surgery
#32
JOURNAL ARTICLE
Eloisa Felipe Fumero, Carolin Walter, Joris Maximillian Frenz, Franca Carlotta Seifert, Vijay Alla, Thorben Hennig, Linus Angenendt, Wolfgang Hartmann, Sebastian Wolf, Hubert Serve, Thomas Oellerich, Georg Lenz, Carsten Müller-Tidow, Christoph Schliemann, Otmar Huber, Martin Dugas, Matthias Mann, Ashok Kumar Jayavelu, Jan-Henrik Mikesch, Maria Francisca Arteaga
Epigenetic modulation of the cell-intrinsic immune response holds promise as a therapeutic approach for leukemia. However, current strategies designed for transcriptional activation of endogenous transposons and subsequent interferon type-I (IFN-I) response, show limited clinical efficacy. Histone lysine methylation is an epigenetic signature in IFN-I response associated with suppression of IFN-I and IFN stimulated genes, suggesting histone demethylation as key mechanism of reactivation. In this study, we unveil the histone demethylase PHF8 as a direct initiator and regulator of cell-intrinsic immune response in acute myeloid leukemia (AML)...
March 8, 2024: Blood
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JOURNAL ARTICLE
Ashley M Hastings, Ashley Williams, Robert G Surbella Iii, Amy E Hixon, Ana Arteaga
Lanthanide-containing materials are of inter-est in the field of crystal engin-eering because of their unique properties and distinct structure types. In this context, a new samarium-sodium heterometallic coordination polymer, poly[tetra-kis-(μ2 -2-formyl-6-meth-oxy-phenolato)samarium(III)sodium(I)], {[SmNa(C8 H7 O3 )4 ]·solvent} n ( Sm-1 ), was synthesized and crystallized via slow evaporation from a mixture of ethanol and aceto-nitrile. The compound features alternating SmIII and NaI ions, which are linked by ortho -vanillin ( o -vanillin) ligands to form a mono-periodic chain-like coordination polymer...
March 1, 2024: Acta Crystallographica. Section E, Crystallographic Communications
#34
JOURNAL ARTICLE
Camille Keenan, Sabrin Albeituni, Ninad Oak, Alexa N Stroh, Heather Tillman, Yingzhe Wang, Burgess B Freeman, Silvia Alemán-Arteaga, Lauren K Meyer, Rolanda Woods, Katherine C Verbist, Yinmei Zhou, Cheng Cheng, Kim E Nichols
Hemophagocytic lymphohistiocytosis (HLH) comprises a severe hyperinflammatory phenotype driven by the overproduction of cytokines, many of which signal via the JAK/STAT pathway. Indeed, the JAK1/2 inhibitor ruxolitinib has demonstrated efficacy in pre-clinical studies and early-phase clinical trials in HLH. Nevertheless, concerns remain for ruxolitinib-induced cytopenias, which are postulated to result from the blockade of JAK2-dependent hematopoietic growth factors. To explore the therapeutic effects of selective JAK inhibition in mouse models of HLH, we carried out studies incorporating the JAK1 inhibitor itacitinib, the JAK2 inhibitor fedratinib and the JAK1/2 inhibitor ruxolitinib...
March 6, 2024: Blood
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JOURNAL ARTICLE
Juan Francisco Morales Arteaga, Dominik Vodnik, Damijana Kastelec, Mojca Zupanc, Matevž Dular, Jernej Ortar, Marija Đurić, Anela Kaurin, Rok Mihelic, Domen Lestan
Sewage sludge (SS) is rich in plant nutrients, including P, N, and organic C, but often contains toxic metals (TMs), which hinders its potential use in agriculture. The efficiency of removal of TMs by washing with ethylenediamine tetraacetate (EDTA), in combination with hydrodynamic cavitation (HC) and the usability of washed sewage sludge as fertilizer were investigated. The environmental risk was assessed. During 8 wash batches an average 35, 68, 47 and 45 % of Pb, Zn, Cd and Cu, respectively, as well as 22 and 5 % Mn and Fe were removed from the SS...
March 2, 2024: Science of the Total Environment
#36
JOURNAL ARTICLE
Pablo David Ramos Murillo, Gonzalo Fernando Arteaga Guerrero, Medardo Javier Vargas Morante, Carlos Patricio Peñaherrera Carrillo, Daniel Alejandro Ramos Murillo, Pablo Agustin Ramos Guarderas
Lateral meniscus hypermobility is a special condition in which the posterior horn of the lateral meniscus exhibits excessive mobility. This condition can cause pain and locking in the knee, especially during kneeling, deep flexion, or squatting. In this article, we present a surgical technique for the reinsertion of the posterior root of the external meniscus in cases of hypermobility without detachment. The objective is to increase the tension of the meniscotibial and meniscal popliteal ligaments to achieve meniscal stability...
February 2024: Arthroscopy Techniques
#37
JOURNAL ARTICLE
Roisin M Connolly, Victoria Wang, David M Hyman, Petros Grivas, Edith P Mitchell, John J Wright, Elad Sharon, Robert J Gray, Lisa M McShane, Larry V Rubinstein, David R Patton, P Mickey Williams, Stanley R Hamilton, Jue Wang, Kari B Wisinski, James V Tricoli, Barbara A Conley, Lyndsay N Harris, Carlos L Arteaga, Peter J O'Dwyer, Alice P Chen, Keith T Flaherty
PURPOSE: NCI-MATCH assigned patients with advanced cancer and progression on prior treatment, based on genomic alterations in pretreatment tumor tissue. Arm J (EAY131-J) evaluated the combination of trastuzumab/pertuzumab (HP) across HER2-amplified tumors. PATIENTS AND METHODS: Eligible patients had high levels of HER2 amplification [copy number (CN) ≥7] detected by central next-generation sequencing (NGS) or through NCI-designated laboratories. Patients with breast/gastroesophageal adenocarcinoma and those who received prior HER2-directed therapy were excluded...
March 4, 2024: Clinical Cancer Research
#38
JOURNAL ARTICLE
Sergio Alejandro Holguin-Garcia, Ernesto Guevara-Navarro, Alvaro Eduardo Daza-Chica, Maria Alejandra Patiño-Claro, Harold Brayan Arteaga-Arteaga, Gonzalo A Ruz, Reinel Tabares-Soto, Mario Alejandro Bravo-Ortiz
INTRODUCTION: Epilepsy is a disease characterized by an excessive discharge in neurons generally provoked without any external stimulus, known as convulsions. About 2 million people are diagnosed each year in the world. This process is carried out by a neurological doctor using an electroencephalogram (EEG), which is lengthy. METHOD: To optimize these processes and make them more efficient, we have resorted to innovative artificial intelligence methods essential in classifying EEG signals...
March 1, 2024: BMC Medical Informatics and Decision Making
#39
JOURNAL ARTICLE
Emma Warren, Belinda J C Castles, Gillian C Sharratt, Aitor Arteaga
INTRODUCTION: The first direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection were reimbursed via Australia's Pharmaceutical Benefits Scheme (PBS) in March 2016. This was based on the recommendation from the Pharmaceutical Benefits Advisory Committee (PBAC) that the regimens would be acceptably cost-effective at an incremental cost-effectiveness ratio (ICER) no greater than $15,000/quality-adjusted life-year (QALY). Since the initial PBS listings for DAA therapies and subsequent listings of newer DAA treatments such as glecaprevir/pibrentasvir (Maviret® ), the demographics and some of the disease characteristics of currently treated patients have markedly changed...
March 1, 2024: Infectious Diseases and Therapy
#40
JOURNAL ARTICLE
Eunice Lares-Villaseñor, Martha Guevara-Cruz, Samuel Salazar-García, Omar Granados-Portillo, Mariela Vega-Cárdenas, Miguel Ernesto Martinez-Leija, Isabel Medina-Vera, Luis E González-Salazar, Liliana Arteaga-Sanchez, Rocío Guízar-Heredia, Karla G Hernández-Gómez, Aurora E Serralde-Zúñiga, Edgar Pichardo-Ontiveros, Adriana M López-Barradas, Laura Guevara-Pedraza, Guillermo Ordaz-Nava, Azalia Avila-Nava, Armando R Tovar, Patricia E Cossío-Torres, Ulises de la Cruz-Mosso, Celia Aradillas-García, Diana P Portales-Pérez, Lilia G Noriega, Juan M Vargas-Morales
Circulating concentration of arginine, alanine, aspartate, isoleucine, leucine, phenylalanine, proline, tyrosine, taurine and valine are increased in subjects with insulin resistance, which could in part be attributed to the presence of single nucleotide polymorphisms (SNPs) within genes associated with amino acid metabolism. Thus, the aim of this work was to develop a Genetic Risk Score (GRS) for insulin resistance in young adults based on SNPs present in genes related to amino acid metabolism. We performed a cross-sectional study that included 452 subjects over 18 years of age...
2024: PloS One
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