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https://www.readbyqxmd.com/read/28794284/genomic-profiling-of-er-breast-cancers-after-short-term-estrogen-suppression-reveals-alterations-associated-with-endocrine-resistance
#1
Jennifer M Giltnane, Katherine E Hutchinson, Thomas P Stricker, Luigi Formisano, Christian D Young, Monica V Estrada, Mellissa J Nixon, Liping Du, Violeta Sanchez, Paula Gonzalez Ericsson, Maria G Kuba, Melinda E Sanders, Xinmeng J Mu, Eliezer M Van Allen, Nikhil Wagle, Ingrid A Mayer, Vandana Abramson, Henry Gόmez, Monica Rizzo, Weiyi Toy, Sarat Chandarlapaty, Erica L Mayer, Jason Christiansen, Danielle Murphy, Kerry Fitzgerald, Kai Wang, Jeffrey S Ross, Vincent A Miller, Phillip J Stephens, Roman Yelensky, Levi Garraway, Yu Shyr, Ingrid Meszoely, Justin M Balko, Carlos L Arteaga
Inhibition of proliferation in estrogen receptor-positive (ER(+)) breast cancers after short-term antiestrogen therapy correlates with long-term patient outcome. We profiled 155 ER(+)/human epidermal growth factor receptor 2-negative (HER2(-)) early breast cancers from 143 patients treated with the aromatase inhibitor letrozole for 10 to 21 days before surgery. Twenty-one percent of tumors remained highly proliferative, suggesting that these tumors harbor alterations associated with intrinsic endocrine therapy resistance...
August 9, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28790806/perceptions-of-patients-with-rheumatic-diseases-on-the-impact-on-daily-life-and-satisfaction-with-their-medications-rheu-life-a-survey-to-patients-treated-with-subcutaneous-biological-products
#2
Carlos M González, Loreto Carmona, Javier de Toro, Enrique Batlle-Gualda, Antonio I Torralba, María J Arteaga, Luis Cea-Calvo
OBJECTIVE: The aim of this study was to explore perceptions of patients with rheumatic diseases treated with subcutaneous (SC) biological drugs on the impact on daily life and satisfaction with current therapy, including preferred attributes. METHODS: A survey was developed ad hoc by four rheumatologists and three patients, including Likert questions on the impact of disease and treatment on daily life and preferred attributes of treatment. Rheumatologists from 50 participating centers were instructed to handout the survey to 20 consecutive patients with rheumatoid arthritis (RA), axial spondyloarthritis (ax-SpA), or psoriatic arthritis (PsA) receiving SC biological drugs...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28781122/dosimetry-of-99m-tc-dtpa-dmsa-and-mag3-used-in-renal-function-studies-of-newborns-and-children
#3
Marcial Vásquez Arteaga, Víctor Murillo Caballero, Kelman Marín Rengifo
The dose to kidneys of newborns and 1-year old children was calculated using the MIRD methodology. In order to perform renal studies radiopharmaceutical like (99m)Tc-DTPA, (99m) Tc-MAG3 and (99m)Tc-DMSA are used. Here, besides the anatomic and structure information of kidneys another data are provided in benefit of patient, however during the radioisotope decay emitted radiations delivers, totally or partially, their energy. Therefore is important to estimate the internal radiation dose of the organs. The largest dose to kidneys comes from the self-dose and it is due to the charged particles emitted during (99m)Tc decay...
July 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28780962/applicability-of-the-gibbs-adsorption-isotherm-to-the-analysis-of-experimental-surface-tension-data-for-ionic-and-nonionic-surfactants
#4
REVIEW
L Martínez-Balbuena, Araceli Arteaga-Jiménez, Ernesto Hernández-Zapata, César Márquez-Beltrán
The Gibbs Adsorption Isotherm equation is a two-dimensional analogous of the Gibbs-Duhem equation, and it is one of the cornerstones of interface science. It is also widely used to estimate the surface excess concentration (SEC) for surfactants and other compounds in aqueous solution, from surface tension measurements. However, in recent publications some authors have cast doubt on this method. In the present work, we review some of the best available surface tension experimental data, and compare estimations of the SEC, using the Gibbs isotherm method (GIM), to direct measurements reported in the literature...
July 21, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28772559/hrtem-microstructural-characterization-of-%C3%AE-wo3-thin-films-deposited-by-reactive-rf-magnetron-sputtering
#5
A Faudoa-Arzate, A Arteaga-Durán, R J Saenz-Hernández, M E Botello-Zubiate, P R Realyvazquez-Guevara, J A Matutes-Aquino
Though tungsten trioxide (WO3) in bulk, nanosphere, and thin film samples has been extensively studied, few studies have been dedicated to the crystallographic structure of WO3 thin films. In this work, the evolution from amorphous WO3 thin films to crystalline WO3 thin films is discussed. WO3 thin films were fabricated on silicon substrates (Si/SiO2) by RF reactive magnetron sputtering. Once a thin film was deposited, two successive annealing treatments were made: an initial annealing at 400 °C for 6 h was followed by a second annealing at 350 °C for 1 h...
February 17, 2017: Materials
https://www.readbyqxmd.com/read/28769604/molecular-phylogeny-of-atractus-serpentes-dipsadidae-with-emphasis-on-ecuadorian-species-and-the-description-of-three-new-taxa
#6
Alejandro Arteaga, Konrad Mebert, Jorge H Valencia, Diego F Cisneros-Heredia, Nicolás Peñafiel, Carolina Reyes-Puig, José L Vieira-Fernandes, Juan M Guayasamin
We present a molecular phylogeny of snake genus Atractus, with an improved taxon sampling that includes 30 of the 140 species currently recognized. The phylogenetic tree supports the existence of at least three new species in the Pacific lowlands and adjacent Andean slopes of the Ecuadorian Andes, which we describe here. A unique combination of molecular, meristic and color pattern characters support the validity of the new species. With the newly acquired data, we propose and define the Atractus iridescens species group, as well as redefine the Atractus roulei species group...
2017: ZooKeys
https://www.readbyqxmd.com/read/28751448/association-of-fgfr1-with-er%C3%AE-maintains-ligand-independent-er-transcription-and-mediates-resistance-to-estrogen-deprivation-in-er-breast-cancer
#7
Luigi Formisano, Kimberly Mae Stauffer, Christian D Young, Neil E Bhola, Angel L Guerrero-Zotano, Valerie M Jansen, Monica M Estrada, Katherine E Hutchinson, Jennifer M Giltnane, Luis J Schwarz, Yao Lu, Justin M Balko, Olivier Deas, Stefano Cairo, Jean-Gabriel Judde, Ingrid A Mayer, Melinda Sanders, Teresa C Dugger, Roberto Bianco, Thomas Stricker, Carlos L Arteaga
FGFR1 amplification occurs in ~15% of ER+ human breast cancers. We investigated mechanisms by which FGFR1 amplification confers antiestrogen resistance to ER+ breast cancer.<br /><br />Experimental Design: ER+ tumors from patients treated with letrozole before surgery were subjected to Ki67 immunohistochemistry, FGFR1 FISH, and RNA-sequencing. ER+/FGFR1 amplified breast cancer cells and patient-derived xenografts (PDXs) were treated with FGFR1 siRNA or the FGFR tyrosine kinase inhibitor lucitanib...
July 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28750787/high-dose-filgrastim-treatment-of-nonregenerative-pancytopenia-associated-with-chronic-canine-ehrlichiosis
#8
Mauricio Palacios, Rafael Arteaga, Gustavo Calvo
OBJECTIVE: To report the management and outcome of a dog with canine monocytic ehrlichiosis and nonregenerative pancytopenia, with high doses of filgrastim. CASE DESCRIPTION: An 8-year-old male, mixed-breed dog, weighing 5.6kg, presented with a 1-month history of hyporexia, adynamia, and a weight loss of approximately 1kg. The general condition of the dog was observed to be poor as follows: lethargy, tachycardia, marked pallor of the mucous membranes, petechiae on the abdomen, hepatosplenomegaly, and cervical lymphadenopathy...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28720316/pigeons-and-their-droppings-as-reservoirs-of-candida-and-other-zoonotic-yeasts
#9
Inmaculada Rosario Medina, Lorena Román Fuentes, Miguel Batista Arteaga, Fernando Real Valcárcel, Félix Acosta Arbelo, Daniel Padilla Del Castillo, Soraya Déniz Suárez, Otilia Ferrer Quintana, Belinda Vega Gutiérrez, Freddy Silva Sergent, Begoña Acosta-Hernández
BACKGROUND: The importance of pigeons as reservoirs and carriers of Cryptococcus neoformans and other species of this genus is well-known; however, less is known about their role as reservoirs and carriers of other yeasts that impact public health. AIMS: The present study was performed on Gran Canaria Island to define yeasts other than Cryptococcus spp. that have been reported to impact public health and which could be carried by pigeons. METHODS: Samples were obtained from 83 pigeon lofts (Columba livia); moreover, 331 crop samples, 331 cloacal samples and 174 dropping samples were collected...
July 15, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28706147/tumor-p38mapk-signaling-enhances-breast-carcinoma-vascularization-and-growth-by-promoting-expression-and-deposition-of-pro-tumorigenic-factors
#10
Michelle Limoge, Alfiya Safina, Alexander M Truskinovsky, Ieman Aljahdali, Justin Zonneville, Aleksandar Gruevski, Carlos L Arteaga, Andrei V Bakin
The breast carcinoma microenvironment strikingly influences cancer progression and response to therapy. Various cell types in the carcinoma microenvironment show significant activity of p38 mitogen-activated protein kinase (MAPK), although the role of p38MAPK in breast cancer progression is still poorly understood. The present study examined the contribution of tumor p38MAPK to breast carcinoma microenvironment and metastatic capacity. Inactivation of p38MAPK signaling in metastatic breast carcinoma cells was achieved by forced expression of the kinase-inactive mutant of p38/MAPK14 (a dominant-negative p38, dn-p38)...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696691/electronic-and-functional-scope-of-boronic-acid-derived-salicylidenehydrazone-bashy-complexes-as-fluorescent-dyes
#11
María M Alcaide, Fabio M F Santos, Vânia F Pais, Joana Inês Carvalho, Daniel Collado, Ezequiel Pérez-Inestrosa, Jesús F Arteaga, Francisco Boscá, Pedro M P Gois, Uwe Pischel
A series of boronic acid derived salicylidenehydrazone (BASHY) complexes was prepared and photophysically characterized. The dye platform can be modified by (a) electronic tuning along the cyanine-type axis via modification of the donor-acceptor pair and (b) functional tuning via the boronic acid residue. On the one hand, approach (a) allows the control of photophysical parameters such as Stokes shift, emission color, and two-photon-absorption (2PA) cross section. The resulting dyes show emission light-up behavior in nonpolar media and are characterized by high fluorescence quantum yields (ca...
July 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28688728/community-policies-and-programs-to-prevent-obesity-and-child-adiposity
#12
Edward A Frongillo, Stephen B Fawcett, Lorrene D Ritchie, S Sonia Arteaga, Catherine M Loria, Russell R Pate, Lisa V John, Warren J Strauss, Maria Gregoriou, Vicki L Collie-Akers, Jerry A Schultz, Andrew J Landgraf, Jyothi Nagaraja
INTRODUCTION: Evidence regarding impact of community policies and programs (CPPs) to prevent child obesity is limited, and which combinations of strategies and components are most important is not understood. The Healthy Communities Study was an observational study to assess relationships of characteristics and intensity of CPPs with adiposity, diet, and physical activity in children, taking advantage of variation across the U.S. in community actions to prevent child obesity. The study examined the association of CPPs to prevent child obesity with measured BMI and waist circumference, hypothesizing that communities with more-comprehensive CPPs would have children with lower adiposity...
July 5, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28687931/differential-cellular-immune-response-of-galleria-mellonella-to-actinobacillus-pleuropneumoniae
#13
Luis Andrés Arteaga Blanco, Josicelli Souza Crispim, Kenner Morais Fernandes, Leandro Licursi de Oliveira, Monalessa Fábia Pereira, Denise Mara Soares Bazzolli, Gustavo Ferreira Martins
In the present work, we have investigate the cellular immune response of Galleria mellonella larvae against three strains of the gram-negative bacterium Actinobacillus pleuropneumoniae: low-virulence (780), high-virulence (1022) and the serotype 8 reference strain (R8). Prohemocytes, plasmatocytes, granulocytes, oenocytoids and spherulocytes were distinguished according to their size and morphology, their molecular markers and dye-staining properties and their role in the immune response. Total hemocyte count, differential hemocyte count, lysosome activity, autophagic response, cell viability and caspase-3 activation were determined in circulating hemocytes of naive and infected larvae...
July 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28672088/photocaged-competitor-guests-a-general-approach-toward-light-activated-cargo-release-from-cucurbiturils
#14
Miguel A Romero, Nuno Basilio, Artur J Moro, Mara Domingues, José A González-Delgado, Jesús F Arteaga, Uwe Pischel
A general approach toward the light-induced guest release from cucurbit[7]uril by means of a photoactivatable competitor was devised. An o-nitrobenzyl-caged competitor is photolyzed to generate a competitive guest that can displace cargo from the host macrocycle solely based on considerations of chemical equilibrium. With this tool the release of terpene guests from inclusion complexes with cucurbit[7]uril was demonstrated. The binding of the herein investigated terpenes, all being lead fragrant components in essential oils, has been characterized for the first time...
July 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28666526/-comparison-of-results-of-open-simple-nephrectomy-secondary-to-lithiasis-in-patients-with-and-without-nephrostomy
#15
Luis Daniel Carrillo-Córdova, Jean Manuel Jiménez-Villavicencio, Jhonatan Vitar-Sandoval, Roberto Carlos Sarabia-Estrada, Hugo Rivera-Astorga, Gerardo Rodrigo Lemus-Mena, Eduardo Sánchez-Meza, Jorge Raul Carrillo-Córdova, Eli Jalil Camilo-Martínez, Alejandro Rosas-Ramírez, José Francisco Virgen-Gutiérrez, Jorge Jaspersen-Gastelum, Mateo Leopoldo Garduño-Arteaga
BACKGROUND: Simple nephrectomy is the procedure of choice in the treatment of excluded kidneys. The purpose of this study was to describe and compare surgical results in open simple retroperitoneal nephrectomies in patients with and without nephrostomy. METHODOLOGY: 58 patients were analyzed. The demographic parameters of patients with nephrostomy were compared to patients without nephrostomy (age, gender, weight, lithium localization, transoperative variables (surgical time, transoperative bleeding) and postoperative variables (need for intensive care, need for transfusion, surgical wound infection and hospital stay days) RESULTS: Statistically significant differences were found for the variables of operative bleeding (p=0...
June 27, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28645201/benznidazole-treatment-safety-the-m%C3%A3-decins-sans-fronti%C3%A3-res-experience-in-a-large-cohort-of-bolivian-patients-with-chagas-disease
#16
Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Alejandro Marcel Hasslocher-Moreno, Marcelo Teixeira de Holanda, Andrea Silvestre de Sousa, Luiz Henrique Conde Sangenis, Pedro Emmanuel Alvarenga Americano do Brasil, Roger Arteaga Mejía, Carina Perotti Fux, Juan-Carlos Cubides, Roberto Magalhães Saraiva, Lucia Maria Brum-Soares
Background: Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment. Objectives: To verify the incidence and possible factors associated with the suspension of benznidazole treatment in a large cohort of patients. Methods: We included 2075 patients treated with benznidazole during the projects managed by the medical humanitarian organization Doctors Without Borders (Médecins Sans Frontières) in Bolivia from 2009 to 2013...
June 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28627211/consumo-de-huevo-y-enfermedad-cardiovascular-una-revisi%C3%A3-n-de-la-literatura-cient%C3%A3-fica
#17
Catalina Dussaillant, Guadalupe Echeverría, Jaime Rozowski, Nicolás Velasco, Antonio Arteaga, Attilio Rigotti
El huevo es un alimento que aporta proteína de alta calidad y numerosos nutrientes con potenciales beneficios para la salud. Sin embargo, la aparición de la enfermedad cardiovascular como importante causa de morbilidad y mortalidad en el mundo, junto con la identificación de los niveles elevados de colesterol plasmático como factor de riesgo para esta patología, llevó, en los años 70, a profesionales e instituciones de salud a limitar el consumo de colesterol y, por tanto, de huevo en la población. Hasta la fecha, los análisis de cohortes prospectivas tienden a mostrar que el consumo de hasta un huevo diario no aumenta significativamente el riesgo cardiovascular en la población sana...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28599955/inequities-in-visual-health-and-health-services-use-in-a-rural-region-in-spain
#18
Sergio Latorre-Arteaga, José Fernández-Sáez, Diana Gil-González
OBJECTIVE: To analyse perceived visual health and health services use in a rural population in relation to socioeconomic characteristics and compared with the general population in Spain. METHOD: Cross-sectional study in a rural population using a structured questionnaire including questions comparable to the Spanish National Health Survey (2012). A descriptive analysis was carried out through the calculation of frequencies and prevalence, the χ(2) test for independent variables, contrasts of proportions and logistic regression to obtain associations between the rural and general populations and socioeconomic variables...
June 6, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28589974/multifunctional-catalysis-stereoselective-construction-of-%C3%AE-methylidene-%C3%AE-lactams-via-an-amidation-rauhut-currier-sequence
#19
Kenta Kishi, Fernando Arteaga Arteaga, Shinobu Takizawa, Hiroaki Sasai
Mixing of acryloylchloride, dienone 2, N,N-diisopropylethylamine with chiral organocatalyst 5a, which could simultaneously act as Brønsted and Lewis base catalysts, led to a one-pot amidation/Rauhut-Currier sequence, affording α-methylidene-γ-lactams 4. Catalyst 5a could be recovered and reused by acid/base extraction without any loss of catalytic activity in the stepwise protocol.
July 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28576675/buparlisib-plus-fulvestrant-versus-placebo-plus-fulvestrant-in-postmenopausal-hormone-receptor-positive-her2-negative-advanced-breast-cancer-belle-2-a-randomised-double-blind-placebo-controlled-phase-3-trial
#20
José Baselga, Seock-Ah Im, Hiroji Iwata, Javier Cortés, Michele De Laurentiis, Zefei Jiang, Carlos L Arteaga, Walter Jonat, Mark Clemons, Yoshinori Ito, Ahmad Awada, Stephen Chia, Agnieszka Jagiełło-Gruszfeld, Barbara Pistilli, Ling-Ming Tseng, Sara Hurvitz, Norikazu Masuda, Masato Takahashi, Peter Vuylsteke, Soulef Hachemi, Bharani Dharan, Emmanuelle Di Tomaso, Patrick Urban, Cristian Massacesi, Mario Campone
BACKGROUND: Phosphatidylinositol 3-kinase (PI3K) pathway activation is a hallmark of endocrine therapy-resistant, hormone receptor-positive breast cancer. This phase 3 study assessed the efficacy of the pan-PI3K inhibitor buparlisib plus fulvestrant in patients with advanced breast cancer, including an evaluation of the PI3K pathway activation status as a biomarker for clinical benefit. METHODS: The BELLE-2 trial was a randomised, double-blind, placebo-controlled, multicentre study...
July 2017: Lancet Oncology
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