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https://www.readbyqxmd.com/read/28198924/the-issue-of-race-in-the-work-of-domingos-guedes-cabral
#1
Juanma Sánchez Arteaga, Ronnie Jorge Tavares de Almeida, Charbel Niño El-Hani
In 1875 Bahia, medicine and evolutionism were used by the physician, journalist, and republican militant Domingos Guedes Cabral as ideological weapons to propose a radical program of social reforms in Brazil in the areas of education, marriage control, medical care to the alienated, changes in the penal system, etc., all of which were based on the scientific knowledge of that time. Among the social ideas of Guedes Cabral, the question of race will be the main focus of this analysis. In this sense, Domingos Guedes Cabral is a particularly significant example for understanding the initial steps in the peculiar alliance between evolutionism, medicine, and scientific racism in Brazil since the 1870s, when Darwinism first arrived in the country...
December 2016: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/28188683/functional-kras-mutations-and-a-potential-role-for-pi3k-akt-activation-in-wilms-tumors
#2
Dina Polosukhina, Harold D Love, Hernan Correa, Zengliu Su, Kimberly B Dahlman, William Pao, Harold L Moses, Carlos L Arteaga, Harold N Lovvorn, Roy Zent, Peter E Clark
Wilms tumor (WT) is the most common renal neoplasm of childhood and affects 1 in 10,000 children aged less than 15 years. These embryonal tumors are thought to arise from primitive nephrogenic rests that derive from the metanephric mesenchyme during kidney development and are characterized partly by increased Wnt/β-catenin signaling. We previously showed that coordinate activation of Ras and β-catenin accelerates the growth and metastatic progression of a murine WT model. Here, we show that activating KRAS mutations can be found in human WT...
February 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28185696/mediterranean-diet-adherence-by-patients-with-primary-open-angle-glaucoma
#3
J A Abreu-Reyes, D Álvarez-Luis, V Arteaga-Hernández, M Sánchez-Mendez, R Abreu-González
OBJECTIVE: To study the adherence to the Mediterranean diet in patients affected by primary open angle glaucoma (POAG). MATERIALS AND METHODS: An observational study was conducted to assess the adherence to the Mediterranean diet in patients affected by POAG, and who attended the Ophthalmology Department of the Canary Islands University Hospital. The study included completing a 14-item questionnaire validated by the PREDIMED Study, in person or by telephone. RESULTS: A total of 100 questionnaires were completed successfully by 50 males and 50 females...
February 6, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28144393/percutaneous-drainage-as-a-first-therapeutic-step-prior-to-surgery-in-liver-hydatid-cyst-abscess-is-it-worth-it
#4
Aylhin J Lopez-Marcano, Jose M Ramia, Vladimir Arteaga, Roberto De la Plaza, Jhonny D Gonzales, Anibal Medina
AIM: To delay surgery until the patient is in a better condition, and thus to decrease postoperative morbidity. METHODS: Using this algorithm we treated three patients aged 55, 75 and 80 years. In all three patients the clinical presentation was fever without a clear source of infection; all had nonspecific symptoms such as general malaise, dyspnea, and abdominal discomfort in the previous 15 d. They came to the emergency room at our hospital due to deterioration of their general condition...
January 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28134843/role-of-antioxidants-in-neonatal-hypoxic-ischemic-brain-injury-new-therapeutic-approaches
#5
REVIEW
Olatz Arteaga, Antonia Álvarez, Miren Revuelta, Francisco Santaolalla, Andoni Urtasun, Enrique Hilario
Hypoxic-ischemic brain damage is an alarming health and economic problem in spite of the advances in neonatal care. It can cause mortality or detrimental neurological disorders such as cerebral palsy, motor impairment and cognitive deficits in neonates. When hypoxia-ischemia occurs, a multi-faceted cascade of events starts out, which can eventually cause cell death. Lower levels of oxygen due to reduced blood supply increase the production of reactive oxygen species, which leads to oxidative stress, a higher concentration of free cytosolic calcium and impaired mitochondrial function, triggering the activation of apoptotic pathways, DNA fragmentation and cell death...
January 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28124919/direct-catalytic-asymmetric-aldol-reaction-of-%C3%AE-alkylamides
#6
Zijian Liu, Toshifumi Takeuchi, Roman Pluta, Fernando Arteaga Arteaga, Naoya Kumagai, Masakatsu Shibasaki
A catalytic asymmetric aldol reaction directly employing amides as latent enolates has remained elusive because of the resistance of amides to enolization. A direct aldol reaction of α-alkylamides without any electron-withdrawing group harnessed by specific activation of 7-azaindoline amides under soft Lewis acid/Brønsted base cooperative catalysis is reported. Diastereo- and enantioselective coupling with ynals and aromatic aldehydes as well as divergent functional group interconversion of the amide provided expeditious access to a variety of aliphatic and aromatic chiral building blocks...
January 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28112343/-intestinal-obstruction-due-to-ascaris-lumbricoides-infection-in-a-geriatric-patient
#7
Alfredo Chiappe, Kovy Arteaga, Cristhian Resurrección, Marcos Ñavincopa, Eduardo Ticona
Ascaris lumbricoides is considered the largest intestinal nematode with a higher incidence in the childhood, representing a truly medical and public health problem, principally in undeveloped countries. We present the case of an 83 year old man, born and coming from the amazon region, without any relevant previous history of disease, admitted in the emergency department of our hospital for presenting intestinal obstruction and also presumptive biliary obstruction due to multiple balls of parasites, requiring immediate surgical intervention...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28105702/hydrodynamic-effects-in-soft-matter-self-assembly-the-case-of-j-aggregates-of-amphiphilic-porphyrins
#8
REVIEW
Josep M Ribo, Zoubir El-Hachemi, Oriol Arteaga, Adolf Canillas, Joaquim Crusats
Chiral J-aggregates of achiral amphiphilic porphyrins (4-sulfonatophenyl and aryl meso-substituted porphyrins) show several effects under the hydrodynamic forces of common stirring. These effects can be classified as pure mechanic (e. g. elasticity, plasticity and breaking of the self-assembly non-covalent bonding) and chemically selective as detected in the formation/growth of the nanoparticles. Diastereoselective, enantioselective and, depending on the sign of chiral shear forces, even enantiospecific selections have been described...
January 20, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28092242/-prehospital-emergency-care-injuries-from-external-causes-in-a-region-of-venezuela
#9
Rafael Herrera, Daniel Bastidas, Everilda Arteaga, Gilberto Bastidas
BACKGROUND: Worldwide, approximately 3 500 000 people die every year as a result of injuries from external causes, in Venezuela these arte the third leading cause of overall morbidity. Nevertheless, in the country there are no records of the defining aspects of prehospital emergency care as a tool to address this socio-health problem, the aim of this investigation. METHODS: A descriptive, transversal, field study based on the information recorded daily for a year paramedics was performed...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28059227/vector-and-matrix-states-for-mueller-matrices-of-nondepolarizing-optical-media
#10
Ertan Kuntman, M Ali Kuntman, Oriol Arteaga
Nondepolarizing Mueller matrices contain up to seven independent parameters. However, these seven parameters typically do not appear explicitly among the measured 16 parameters of a Mueller matrix, so that they are not directly accessible for physical interpretation. This work shows that all the information contained in a nondepolarizing Mueller matrix can be conveniently expressed in terms of a four component covariance vector state or a generating 4×4 matrix, which can be understood as a matrix state. The generating matrix, besides being directly related to the nondepolarizing Mueller matrix, mimics all properties of the Jones matrix and provides a powerful mathematical tool for formulating all properties of nondepolarizing systems, including the Mueller symmetries and the anisotropy coefficients...
January 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28040315/-barometer-of-type-2-diabetes-in-primary-care-metabolic-control-styles-of-life-and-morbidity-profile
#11
David Pérez-Manchón, María Lorena Rodríguez-Álvarez, Claudia Alcívar-Arteaga, Mercedes Redondo-Pico, Elena Ramos-Quirós
OBJECTIVE: Knowing the profile of cardiovascular morbidity, degree of control and lifestyles in type 2 diabetes. METHOD: Randomized multicenter cross-sectional study conducted in 2015 in primary care with 129 diabetics. It included sociodemographic variables, microvascular and macrovascular complications, organic damage, comorbidity and lifestyles of smoking, exercise and adherence to Mediterranean diet. Metabolic control was assessed with the latest annual glycosylated haemoglobin...
December 28, 2016: Enfermería Clínica
https://www.readbyqxmd.com/read/28032846/non-adherence-to-subcutaneous-biological-medication-in-patients-with-rheumatoid-arthritis-a-multicentre-non-interventional-study
#12
Jaime Calvo-Alén, Indalecio Monteagudo, Georgina Salvador, Tomás R Vázquez-Rodríguez, Juan V Tovar-Beltrán, Paloma Vela, Francisco Maceiras, Sagrario Bustabad, José A Román-Ivorra, Consuelo Díaz-Miguel, José Rosas, Enrique Raya, Loreto Carmona, Luis Cea-Calvo, María J Arteaga, Sabela Fernández, Carlos Marras
OBJECTIVES: To evaluate non-adherence to prescribed subcutaneous biologicals in rheumatoid arthritis (RA) patients in Spain. METHODS: ARCO (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs) was a multicentre, non-interventional retrospective study involving 42 rheumatology clinics from representative hospitals throughout Spain. The primary objective was to assess the percentage of patients (aged ≥18 years with an established RA diagnosis) with non-adherence to prescribed subcutaneous biologicals using clinical records and hospital pharmacy dispensing logs as the primary information sources...
December 28, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28031425/phase-ib-study-of-safety-and-pharmacokinetics-of-the-pi3k-inhibitor-sar245408-with-the-her3-neutralizing-human-antibody-sar256212-in-patients-with-solid-tumors
#13
Vandana G Abramson, Jeffrey G Supko, Tarah Ballinger, James M Cleary, John F Hilton, Sara Tolaney, Nicole G Chau, Daniel C Cho, Joanne J Lager, Joseph Pearlberg, Geoffrey I Shapiro, Carlos L Arteaga
PURPOSE: This phase Ib study was designed to determine the maximum tolerated dose, safety, preliminary efficacy, and pharmacokinetics of the HER3 (ErbB3) monoclonal antibody SAR256212 in combination with the oral phosphoinositide 3-kinase (PI3K) inhibitor SAR245408 for patients with metastatic or locally advanced solid tumors. EXPERIMENTAL DESIGN: Patients received the combination of intravenous SAR256212 and oral SAR245408 in a 3+3 dose escalation design until occurrence of disease progression or dose-limiting toxicity...
December 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28029349/retrospective-observational-epidemiologic-study-of-sensitization-to-gold-sodium-thiosulfate-in-the-allergy-clinic-of-a-tertiary-hospital
#14
M Arteaga-Henríquez, I Latour-Álvarez, E García-Peris, N Pérez-Robayna
No abstract text is available yet for this article.
October 28, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28027477/aerobic-biodegradation-of-amphoteric-amine-oxide-based-surfactants-effect-of-molecular-structure-initial-surfactant-concentration-and-ph
#15
Francisco Ríos, Manuela Lechuga, Mercedes Fernández-Serrano, Alejandro Fernández-Arteaga
The present study was designed to provide information regarding the effect of the molecular structure of amphoteric amine-oxide-based surfactants and the initial surfactant concentration on their ultimate biodegradation. Moreover, given this parameter's pH-dependence, the effect of pH was also investigated. Three amine-oxide-based surfactants with structural differences in their hydrophobic alkyl chain were tested: Lauramine oxide (AO-R12), Myristamine oxide (AO-R14) and Cocamidopropylamine oxide (AO-Cocoamido)...
December 18, 2016: Chemosphere
https://www.readbyqxmd.com/read/28011460/18f-fluoroestradiol-pet-ct-measurement-of-estrogen-receptor-suppression-during-a-phase-i-trial-of-the-novel-estrogen-receptor-targeted-therapeutic-gdc-0810
#16
Yingbing Wang, Karen Ayres, Debra A Goldman, Maura N Dickler, Aditya Bardia, Ingrid A Mayer, Eric P Winer, Jill Fredrickson, Carlos L Arteaga, José Baselga, H Charles Manning, Umar Mahmood, Gary A Ulaner
PURPOSE: Evaluate 18F-fluoroestradiol (FES) PET/CT as a biomarker of estrogen receptor (ER) occupancy and/or downregulation during phase I dose escalation of the novel ER targeting therapeutic GDC-0810, and help select drug dosage for subsequent clinical trials. EXPERIMENTAL DESIGN: In a phase I clinical trial of GDC-0810, patients with ER-positive metastatic breast cancer underwent FES PET/CT before beginning therapy and at cycle 2, day 3 of GDC-0810 therapy. Up to five target lesions were selected per patient, and FES SUV corrected for background was recorded for each lesion pre-therapy and on-therapy...
December 23, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28005248/characterizing-architectural-distortion-in-mammograms-by-linear-saliency
#17
Fabián Narváez, Jorge Alvarez, Juan D Garcia-Arteaga, Jonathan Tarquino, Eduardo Romero
Architectural distortion (AD) is a common cause of false-negatives in mammograms. This lesion usually consists of a central retraction of the connective tissue and a spiculated pattern radiating from it. This pattern is difficult to detect due the complex superposition of breast tissue. This paper presents a novel AD characterization by representing the linear saliency in mammography Regions of Interest (ROI) as a graph composed of nodes corresponding to locations along the ROI boundary and edges with a weight proportional to the line intensity integrals along the path connecting any pair of nodes...
February 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/27995373/treatment-of-reno-ureteral-colic-by-twelfth-intercostal-nerve-block-with-lidocaine-versus-intramuscular-diclofenac
#18
Miguel Maldonado-Avila, Marcos Del Rosario-Santiago, Jesus Emmanuel Rosas-Nava, Hugo Arturo Manzanilla-Garcia, Victor Manuel Rios-Davila, Patricia Rodriguez-Nava, Roberto Alejandro Vela-Mollinedo, Mateo Leopoldo Garduño-Arteaga
INTRODUCTION AND OBJECTIVE: Renal colic is one of the most intense pains known to humans. Standard treatment usually consists of nonsteroidal anti-inflammatory drugs and opiates, but they do not always provide optimum efficacy and speed in relieving the pain. For more than 25 years, our hospital has been employing twelfth subcostal nerve block. The objective of the present study was to compare the efficacy of subcostal nerve block with lidocaine versus intramuscular diclofenac in renal colic management...
December 19, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27988065/cilioretinal-obstruction-during-pregnancy
#19
J Vila-Arteaga, M M Suriano, A Martínez-Lajara
PURPOSE: To determine the number of patients diagnosed over a 5-year period with isolated occlusion of the cilioretinal artery (CRAO) whilst pregnant, as well as to describe the outcomes and ophthalmological sequelae of this condition in pregnant woman. METHODS: A retrospective study of the medical records. RESULTS: From the 135 patients diagnosed with retinal arterial occlusion of all of our series, 20 (14.8%) had CRAO, and 2 (1.48%) of these were pregnant...
December 14, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27970587/three-monthly-long-acting-formulation-of-paliperidone-palmitate-is-a-dominant-treatment-option-cost-saving-while-adding-qalys-compared-to-the-one-monthly-formulation-in-the-treatment-of-schizophrenia-in-france
#20
C Arteaga Duarte, X Colin, R De Moor, P Guillon, C W van Gils
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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