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https://www.readbyqxmd.com/read/28105702/hydrodynamic-effects-in-soft-matter-self-assembly-the-case-of-j-aggregates-of-amphiphilic-porphyrins
#1
REVIEW
Josep M Ribo, Zoubir El-Hachemi, Oriol Arteaga, Adolf Canillas, Joaquim Crusats
Chiral J-aggregates of achiral amphiphilic porphyrins (4-sulfonatophenyl and aryl meso-substituted porphyrins) show several effects under the hydrodynamic forces of common stirring. These effects can be classified as pure mechanic (e. g. elasticity, plasticity and breaking of the self-assembly non-covalent bonding) and chemically selective as detected in the formation/growth of the nanoparticles. Diastereoselective, enantioselective and, depending on the sign of chiral shear forces, even enantiospecific selections have been described...
January 20, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28092242/-prehospital-emergency-care-injuries-from-external-causes-in-a-region-of-venezuela
#2
Rafael Herrera, Daniel Bastidas, Everilda Arteaga, Gilberto Bastidas
BACKGROUND: Worldwide, approximately 3 500 000 people die every year as a result of injuries from external causes, in Venezuela these arte the third leading cause of overall morbidity. Nevertheless, in the country there are no records of the defining aspects of prehospital emergency care as a tool to address this socio-health problem, the aim of this investigation. METHODS: A descriptive, transversal, field study based on the information recorded daily for a year paramedics was performed...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28059227/vector-and-matrix-states-for-mueller-matrices-of-nondepolarizing-optical-media
#3
Ertan Kuntman, M Ali Kuntman, Oriol Arteaga
Nondepolarizing Mueller matrices contain up to seven independent parameters. However, these seven parameters typically do not appear explicitly among the measured 16 parameters of a Mueller matrix, so that they are not directly accessible for physical interpretation. This work shows that all the information contained in a nondepolarizing Mueller matrix can be conveniently expressed in terms of a four component covariance vector state or a generating 4×4 matrix, which can be understood as a matrix state. The generating matrix, besides being directly related to the nondepolarizing Mueller matrix, mimics all properties of the Jones matrix and provides a powerful mathematical tool for formulating all properties of nondepolarizing systems, including the Mueller symmetries and the anisotropy coefficients...
January 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28040315/-barometer-of-type-2-diabetes-in-primary-care-metabolic-control-styles-of-life-and-morbidity-profile
#4
David Pérez-Manchón, María Lorena Rodríguez-Álvarez, Claudia Alcívar-Arteaga, Mercedes Redondo-Pico, Elena Ramos-Quirós
OBJECTIVE: Knowing the profile of cardiovascular morbidity, degree of control and lifestyles in type 2 diabetes. METHOD: Randomized multicenter cross-sectional study conducted in 2015 in primary care with 129 diabetics. It included sociodemographic variables, microvascular and macrovascular complications, organic damage, comorbidity and lifestyles of smoking, exercise and adherence to Mediterranean diet. Metabolic control was assessed with the latest annual glycosylated haemoglobin...
December 28, 2016: Enfermería Clínica
https://www.readbyqxmd.com/read/28032846/non-adherence-to-subcutaneous-biological-medication-in-patients-with-rheumatoid-arthritis-a-multicentre-non-interventional-study
#5
Jaime Calvo-Alén, Indalecio Monteagudo, Georgina Salvador, Tomás R Vázquez-Rodríguez, Juan V Tovar-Beltrán, Paloma Vela, Francisco Maceiras, Sagrario Bustabad, José A Román-Ivorra, Consuelo Díaz-Miguel, José Rosas, Enrique Raya, Loreto Carmona, Luis Cea-Calvo, María J Arteaga, Sabela Fernández, Carlos Marras
OBJECTIVES: To evaluate non-adherence to prescribed subcutaneous biologicals in rheumatoid arthritis (RA) patients in Spain. METHODS: ARCO (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs) was a multicentre, non-interventional retrospective study involving 42 rheumatology clinics from representative hospitals throughout Spain. The primary objective was to assess the percentage of patients (aged ≥18 years with an established RA diagnosis) with non-adherence to prescribed subcutaneous biologicals using clinical records and hospital pharmacy dispensing logs as the primary information sources...
December 28, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28031425/phase-ib-study-of-safety-and-pharmacokinetics-of-the-pi3k-inhibitor-sar245408-with-the-her3-neutralizing-human-antibody-sar256212-in-patients-with-solid-tumors
#6
Vandana G Abramson, Jeffrey G Supko, Tarah Ballinger, James M Cleary, John F Hilton, Sara Tolaney, Nicole G Chau, Daniel C Cho, Joanne J Lager, Joseph Pearlberg, Geoffrey I Shapiro, Carlos L Arteaga
PURPOSE: This phase Ib study was designed to determine the maximum tolerated dose, safety, preliminary efficacy, and pharmacokinetics of the HER3 (ErbB3) monoclonal antibody SAR256212 in combination with the oral phosphoinositide 3-kinase (PI3K) inhibitor SAR245408 for patients with metastatic or locally advanced solid tumors. EXPERIMENTAL DESIGN: Patients received the combination of intravenous SAR256212 and oral SAR245408 in a 3+3 dose escalation design until occurrence of disease progression or dose-limiting toxicity...
December 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28029349/retrospective-observational-epidemiologic-study-of-sensitization-to-gold-sodium-thiosulfate-in-the-allergy-clinic-of-a-tertiary-hospital
#7
M Arteaga-Henríquez, I Latour-Álvarez, E García-Peris, N Pérez-Robayna
No abstract text is available yet for this article.
October 28, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28027477/aerobic-biodegradation-of-amphoteric-amine-oxide-based-surfactants-effect-of-molecular-structure-initial-surfactant-concentration-and-ph
#8
Francisco Ríos, Manuela Lechuga, Mercedes Fernández-Serrano, Alejandro Fernández-Arteaga
The present study was designed to provide information regarding the effect of the molecular structure of amphoteric amine-oxide-based surfactants and the initial surfactant concentration on their ultimate biodegradation. Moreover, given this parameter's pH-dependence, the effect of pH was also investigated. Three amine-oxide-based surfactants with structural differences in their hydrophobic alkyl chain were tested: Lauramine oxide (AO-R12), Myristamine oxide (AO-R14) and Cocamidopropylamine oxide (AO-Cocoamido)...
December 18, 2016: Chemosphere
https://www.readbyqxmd.com/read/28011460/18f-fluoroestradiol-pet-ct-measurement-of-estrogen-receptor-suppression-during-a-phase-i-trial-of-the-novel-estrogen-receptor-targeted-therapeutic-gdc-0810
#9
Yingbing Wang, Karen Ayres, Debra A Goldman, Maura N Dickler, Aditya Bardia, Ingrid A Mayer, Eric P Winer, Jill Fredrickson, Carlos L Arteaga, José Baselga, H Charles Manning, Umar Mahmood, Gary A Ulaner
PURPOSE: Evaluate 18F-fluoroestradiol (FES) PET/CT as a biomarker of estrogen receptor (ER) occupancy and/or downregulation during phase I dose escalation of the novel ER targeting therapeutic GDC-0810, and help select drug dosage for subsequent clinical trials. EXPERIMENTAL DESIGN: In a phase I clinical trial of GDC-0810, patients with ER-positive metastatic breast cancer underwent FES PET/CT before beginning therapy and at cycle 2, day 3 of GDC-0810 therapy. Up to five target lesions were selected per patient, and FES SUV corrected for background was recorded for each lesion pre-therapy and on-therapy...
December 23, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28005248/characterizing-architectural-distortion-in-mammograms-by-linear-saliency
#10
Fabián Narváez, Jorge Alvarez, Juan D Garcia-Arteaga, Jonathan Tarquino, Eduardo Romero
Architectural distortion (AD) is a common cause of false-negatives in mammograms. This lesion usually consists of a central retraction of the connective tissue and a spiculated pattern radiating from it. This pattern is difficult to detect due the complex superposition of breast tissue. This paper presents a novel AD characterization by representing the linear saliency in mammography Regions of Interest (ROI) as a graph composed of nodes corresponding to locations along the ROI boundary and edges with a weight proportional to the line intensity integrals along the path connecting any pair of nodes...
February 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/27995373/treatment-of-reno-ureteral-colic-by-twelfth-intercostal-nerve-block-with-lidocaine-versus-intramuscular-diclofenac
#11
Miguel Maldonado-Avila, Marcos Del Rosario-Santiago, Jesus Emmanuel Rosas-Nava, Hugo Arturo Manzanilla-Garcia, Victor Manuel Rios-Davila, Patricia Rodriguez-Nava, Roberto Alejandro Vela-Mollinedo, Mateo Leopoldo Garduño-Arteaga
INTRODUCTION AND OBJECTIVE: Renal colic is one of the most intense pains known to humans. Standard treatment usually consists of nonsteroidal anti-inflammatory drugs and opiates, but they do not always provide optimum efficacy and speed in relieving the pain. For more than 25 years, our hospital has been employing twelfth subcostal nerve block. The objective of the present study was to compare the efficacy of subcostal nerve block with lidocaine versus intramuscular diclofenac in renal colic management...
December 19, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27988065/cilioretinal-obstruction-during-pregnancy
#12
J Vila-Arteaga, M M Suriano, A Martínez-Lajara
PURPOSE: To determine the number of patients diagnosed over a 5-year period with isolated occlusion of the cilioretinal artery (CRAO) whilst pregnant, as well as to describe the outcomes and ophthalmological sequelae of this condition in pregnant woman. METHODS: A retrospective study of the medical records. RESULTS: From the 135 patients diagnosed with retinal arterial occlusion of all of our series, 20 (14.8%) had CRAO, and 2 (1.48%) of these were pregnant...
December 14, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27970587/three-monthly-long-acting-formulation-of-paliperidone-palmitate-is-a-dominant-treatment-option-cost-saving-while-adding-qalys-compared-to-the-one-monthly-formulation-in-the-treatment-of-schizophrenia-in-france
#13
C Arteaga Duarte, X Colin, R De Moor, P Guillon, C W van Gils
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27941963/clinical-and-genetic-findings-in-mexican-patients-with-duane-anomaly-and-radial-ray-malformations-okihiro-syndrome
#14
Óscar F Chacón-Camacho, Jesús Cabral-Macías, Raúl Ayala-Ramírez, Jazmín Arteaga-Vázquez, Yevgeniya Svyryd, Karla Helmes, Nohemí Pérez-Hernández, Osvaldo M Mutchinick, Juan Carlos Zenteno
BACKGROUND: Okihiro syndrome is an autosomal-dominant condition characterized by radial ray malformations associated with Duane anomaly and other clinical characteristics. SALL4 mutations have been identified in 80-90% of patients with Duane- Radial ray defects/Okihiro syndrome. We report the clinical findings and results of SALL4 sequencing from a group of Mexican patients with this disorder. OBJECTIVE: Clinical description and identification of SALL4 mutations in Mexican subjects with radial defects and Duane anomaly...
September 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27931566/barriers-to-organ-transplantation-in-the-algerian-health-system-from-the-perspective-of-health-professionals-a-qualitative-approach
#15
N Laidouni, D Gil-González, S Latorre-Arteaga
BACKGROUND: Organ transplantation is often the only treatment for end-stage organ failure and is considered to be a cost-effective intervention with high impact on the health and quality of life of patients with chronic illnesses. Algeria has low rates of organ donation and transplantation, and health system coverage is not sufficient for the large number of patients awaiting this type of treatment. Physicians' perspectives about the health system are essential to understanding the obstacles present in the development of transplant services...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27924327/universal-access-to-megastigmanes-through-controlled-cyclisation-towards-highly-substituted-cyclohexenes
#16
José A González-Delgado, Miguel A Romero, Uwe Pischel, Jesús F Arteaga
We report the selective formation of cyclohexenes with a tetrasubstituted double bond, the structural key element of megastigmanes. For this purpose the ZrCl4-mediated epoxide ring opening of epoxy-geranylacetone was employed. This approach provides a universal entry to the preparation of the members of the megastigmane family, which was exemplified in the asymmetric synthesis of tectoionol B.
December 7, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27916321/exercise-induced-quantitative-microvolt-t-wave-alternans-in-hypertrophic-cardiomyopathy
#17
Murillo de Oliveira Antunes, Nelson Samesima, Horacio Gomes Pereira Filho, Afonso Yoshikiro Matsumoto, Richard L Verrier, Carlos Alberto Pastore, Edmundo Arteaga-Fernández, Charles Mady
BACKGROUND/PURPOSE: Patients with hypertrophic cardiomyopathy (HCM) have elevated risk for sudden cardiac death (SCD). Our study aimed to quantitatively characterize microvolt T-wave alternans (TWA), a potential arrhythmia risk stratification tool, in this HCM patient population. METHODS: TWA was analyzed with the quantitative modified moving average (MMA) in 132 HCM patients undergoing treadmill exercise testing, grouped according to Maron score risk factors as high-risk (H-Risk, n=67,), or low-risk (L-Risk, n=65, without these risk factors)...
October 28, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27913321/deterioration-of-r-wave-detection-in-pathology-and-noise-a-comprehensive-analysis-using-simultaneous-truth-and-performance-level-estimation
#18
Muhammad Kashif, Stephan Jonas, Thomas Deserno
OBJECTIVE: For long-term electrocardiography (ECG) recordings, accurate R-wave detection is essential. Several algorithms have been proposed but not yet compared on large, noisy, or pathological data, since manual ground truth establishment is impossible on such large data. METHODS: We apply the simultaneous truth and performance level estimation (STAPLE) method to ECG signals comparing 9 R-wave detectors: Pan & Tompkins (1985), Chernenko (2007), Arzeno et al. (2008), Manikandan et al...
December 1, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27896521/pi3k-akt-mtor-role-in-breast-cancer-progression-drug-resistance-and-treatment
#19
Angel Guerrero-Zotano, Ingrid A Mayer, Carlos L Arteaga
Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene and/or loss of a tumor suppressor. Mutations in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway are freqcuently found in breast cancers and associated with cellular transformation, tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK/mTOR are currently in clinical trials, mainly in combination with endocrine therapy and anti-HER2 therapy...
November 28, 2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/27877163/diversification-of-the-vacas1m1-and-vacas2m2-strains-of-helicobacter-pylori-in-meriones-unguiculatus
#20
Sandra Mendoza-Elizalde, Nancy K Arteaga-Resendiz, Pedro Valencia-Mayoral, Raúl C Luna, Sarbelio Moreno-Espinosa, Francisco Arenas-Huertero, Gerardo Zúñiga, Norma Velázquez-Guadarrama
The bacterium Helicobacter pylori exhibits great genetic diversity, and the pathogenic roles of its virulence factors have been widely studied. However, the evolutionary dynamics of H. pylori strains during stomach colonization are not well-characterized. Here, we analyzed the microevolutionary dynamics of the toxigenic strain vacAs1m1, the non-toxigenic strain vacAs2m2, and a combination of both strains in an animal model over time. Meriones unguiculatus were inoculated with the following bacteria: group 1-toxigenic strain vacAs1m1/cagA+/cagE+/babA2+; ST181, group 2-non-toxigenic strain vacAs2m2/cagA+/cagE+/babA2+; ST2901, and group 3-both strains...
2016: Frontiers in Microbiology
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