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https://www.readbyqxmd.com/read/29780789/a-fundamentals-train-the-trainer-approach-to-building-pediatric-critical-care-expertise-in-the-developing-world
#1
Sheri S Crow, Beth A Ballinger, Mariela Rivera, David Tsibadze, Nino Gakhokidze, Nino Zavrashvili, Matthew J Ritter, Grace M Arteaga
Pediatric Fundamental Critical Care Support (PFCCS) is an educational tool for training non-intensivists, nurses, and critical care practitioners in diverse health-care settings to deal with the acute deterioration of pediatric patients. Our objective was to evaluate the PFCCS course as a tool for developing a uniform, reproducible, and sustainable model for educating local health-care workers in the optimal management of critically ill children in the Republic of Georgia. Over a period of 18 months and four visits to the country, we worked with Georgian pediatric critical care leadership to complete the following tasks: (1) survey health-care needs within the Republic of Georgia, (2) present representative PFCCS lectures and simulation scenarios to evaluate interest and obtain "buy-in" from key stakeholders throughout the Georgian educational infrastructure, and (3) identify PFCCS instructor candidates...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29763549/development-of-positron-emission-tomography-pet-radiotracers-for-the-gaba-transporter-1-gat-1
#2
Alexandra R Sowa, Allen F Brooks, Xia Shao, Bradford D Henderson, Phillip S Sherman, Janna Arteaga, Jenelle Stauff, Adam C Lee, Robert A Koeppe, Peter J H Scott, Michael R Kilbourn
In vivo PET imaging of the γ-aminobutyric acid (GABA) receptor complex has been accomplished using radiolabeled benzodiazepine derivatives, but development of specific presynaptic radioligands targeting the neuronal membrane GABA transporter type 1 (GAT-1) has been less successful. The availability of new structure-activity studies of GAT-1 inhibitors and the introduction of a GAT-1 inhibitor (tiagabine, Gabatril® ) into clinical use prompted us to reinvestigate the syntheses of PET ligands for this transporter...
May 15, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29751246/geospatial-analysis-of-residential-proximity-to-open-pit-coal-mining-areas-in-relation-to-micronuclei-frequency-particulate-matter-concentration-and-elemental-enrichment-factors
#3
Lyda Espitia-Pérez, Marcia Arteaga-Pertuz, José Salvador Soto, Pedro Espitia-Pérez, Shirley Salcedo-Arteaga, Karina Pastor-Sierra, Claudia Galeano-Páez, Hugo Brango, Juliana da Silva, João A P Henriques
During coal surface mining, several activities such as drilling, blasting, loading, and transport produce large quantities of particulate matter (PM) that is directly emitted into the atmosphere. Occupational exposure to this PM has been associated with an increase of DNA damage, but there is a scarcity of data examining the impact of these industrial operations in cytogenetic endpoints frequency and cancer risk of potentially exposed surrounding populations. In this study, we used a Geographic Information Systems (GIS) approach and Inverse Distance Weighting (IDW) methods to perform a spatial and statistical analysis to explore whether exposure to PM2...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29746147/female-sex-and-gender-in-lung-sleep-health-and-disease-increased-understanding-of-basic-biological-pathophysiological-and-behavioral-mechanisms-leading-to-better-health-for-female-patients-with-lung-disease
#4
MeiLan K Han, Emilio Arteaga-Solis, John Blenis, Ghada Bourjeily, Deborah J Clegg, Dawn DeMeo, Jeanne Duffy, Ben Gaston, Nicola M Heller, Anna Hemnes, Elizabeth Petri Henske, Raksha Jain, Tim Lahm, Lisa H Lancaster, Joyce Lee, Marianne J Legato, Sherry McKee, Reena Mehra, Alison Morris, Y S Prakash, Martin R Stampfli, Rashmi Gopal-Srivastava, Aaron D Laposky, Antonello Punturieri, Lora Reineck, Xenia Tigno, Janine Clayton
Female sex/gender is an under-characterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or in the case of LAM, are seen almost exclusively in women. In other diseases, presentation differs such as the higher frequency of exacerbations experienced by women with COPD or greater cardiac morbidity among women with sleep disordered breathing...
May 10, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29736325/dynamic-assessment-of-light-induced-vaulting-changes-of-implantable-collamer-lens-with-central-port-by-swept-source-oct-pilot-study
#5
Felix Gonzalez-Lopez, Blas Mompean, Rafael Bilbao-Calabuig, Jorge Vila-Arteaga, Jaime Beltran, Julio Baviera
Purpose: To assess dynamic variations in vault induced by changes in brightness in eyes implanted with phakic collamer intraocular lens (pIOL) with central port for correction of myopia, defining new parameters of vaulting measurement. Methods: We used a noninvasive Fourier-domain swept-source anterior-segment optical coherence tomography (AS-OCT) system to dynamically evaluate the shifts between the pIOL and anterior chamber structures under changing light conditions...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29729053/computed-tomography-is-a-feasible-method-for-quantifying-bone-density-in-macaca-mulatta
#6
Salvador A Solís-Chávez, Manuel A Castillo-Rivera, Marcela Arteaga-Silva, Alejandra Ibáñez-Contreras, Braulio Hernández-Godínez, Andrés Morón-Mendoza, Gamaliel Mendoza-Cuevas, Axayácatl Morales-Guadarrama, Emilio Sacristan-Rock
Osteopathologies are a result of advanced age and decreased bone density and represent a global health problem. It is therefore important to generate models for longitudinal studies of the pathophysiology in order to improve early diagnosis and develop preventive therapies. For this kind of research, the use of computed tomography (CT) to evaluate bone health offers advantages over other techniques since it provides more complete information. The aim of this prospective, pilot study was to obtain measurements of the left femur from a population in captivity of 32 rhesus monkeys (Macaca mulatta) in order to standardize the model for future research...
May 4, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29727461/measuring-the-gradualist-approach-to-internationalization-empirical-evidence-from-the-wine-sector
#7
Mónica Clavel San Emeterio, Rubén Fernández-Ortiz, Jesús Arteaga-Ortiz, Pablo Dorta-González
The objective of this paper is to fill a gap in the literature on internationalization, in relation to the absence of objective and measurable performance indicators for the process of how firms sequentially enter external markets. To that end, this research develops a quantitative tool for use as a performance indicator of gradualness for firms entering external markets at a sectoral level. The performance indicator is based on firms' export volumes, number of years operating in the export market, geographic areas targeted for export and when exports began to each area...
2018: PloS One
https://www.readbyqxmd.com/read/29718092/updated-results-from-monaleesa-2-a-phase-iii-trial-of-first-line-ribociclib-plus-letrozole-versus-placebo-plus-letrozole-in-hormone-receptor-positive-her2-negative-advanced-breast-cancer
#8
G N Hortobagyi, S M Stemmer, H A Burris, Y S Yap, G S Sonke, S Paluch-Shimon, M Campone, K Petrakova, K L Blackwell, E P Winer, W Janni, S Verma, P Conte, C L Arteaga, D A Cameron, S Mondal, F Su, M Miller, M Elmeliegy, C Germa, J O'Shaughnessy
Background: The phase III MONALEESA-2 study demonstrated significantly prolonged progression-free survival (PFS) and a manageable toxicity profile for first-line ribociclib plus letrozole versus placebo plus letrozole in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer. Here we report updated efficacy and safety data, together with exploratory biomarker analyses, from the MONALEESA-2 study. Patients and methods: A total of 668 postmenopausal women with HR+, HER2- recurrent/metastatic breast cancer were randomized (1:1; stratified by presence/absence of liver and/or lung metastases) to ribociclib (600 mg/day; 3-weeks-on/1-week-off; 28-day treatment cycles) plus letrozole (2...
April 27, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29718010/phenotypic-variability-in-a-mexican-mestizo-family-with-retinal-vasculopathy-with-cerebral-leukodystrophy-and-trex1-mutation-p-v235gfs-6
#9
Nancy Monroy-Jaramillo, Aurelio Cerón, Elizabeth León, Verónica Rivas, Adriana Ochoa-Morales, María Georgina Arteaga-Alcaraz, Fausto Carlos Nocedal-Rustrian, Cecilia Gallegos, María Elisa Alonso-Vilatela, Teresa Corona, José Flores
Background: Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an adult-onset, autosomal dominant disease involving microvessels of the brain and eye resulting in central nervous system degeneration with visual disturbances, stroke, motor impairment, and cognitive decline. Frameshift mutations at the C-terminus of TREX1 gene are the molecular cause of this disorder. Objectives: The objective of this study is to present the different clinical manifestations of RVCL in three-related patients and to investigate the presence of TREX1 mutation in the extended genealogy...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29704795/silica-micro-and-nanoparticles-reduce-the-toxicity-of-surfactant-solutions
#10
Francisco Ríos, Alejandro Fernández-Arteaga, Mercedes Fernández-Serrano, Encarnación Jurado, Manuela Lechuga
In this work, the toxicity of hydrophilic fumed silica micro- and nanoparticles of various sizes (7 nm, 12 nm, and 50 μm) was evaluated using the luminescent bacteria Vibrio fischeri. In addition, the toxicity of an anionic surfactant solution (ether carboxylic acid), a nonionic surfactant solution (alkyl polyglucoside), and a binary (1:1) mixture of these solutions all containing these silica particles was evaluated. Furthermore, this work discusses the adsorption of surfactants onto particle surfaces and evaluates the effects of silica particles on the surface tension and critical micellar concentration (CMC) of these anionic and nonionic surfactants...
April 20, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29683974/pancreatic-neuroendocrine-tumors-and-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-a-systematic-review
#11
Alba Manuel-Vazquez, José Manuel Ramia, Raquel Latorre-Fragua, Ainhoa Valle-Rubio, Vladimir Arteaga-Peralta, Carmen Ramiro-Pérez, Roberto de la Plaza-Llamas
OBJECTIVES: This study aimed to identify factors that explain the association of intraductal papillary mucinous neoplasms-pancreatic neuroendocrine tumors (IPMNs-PNETs), radiological characteristics, and factors that might guide therapy. METHODS: We performed a systematic review of the literature to search for articles on concurrent IPMN-PNET, mixed endocrine-exocrine pancreatic tumors, and/or PNET with an intraductal growth pattern. RESULTS: A review of the literature suggests that there is some confusion about association of IPMNs-PNETs...
May 2018: Pancreas
https://www.readbyqxmd.com/read/29673828/decision-making-for-the-treatment-of-climacteric-symptoms-using-the-menopause-rating-scale
#12
Juan Enrique Blümel, Eugenio Arteaga, Joaquín Parra, Carolina Monsalve, Valentina Reyes, María Soledad Vallejo, Rosa Chea
OBJECTIVE: The Menopause Rating Scale (MRS) is one of the most frequently used instruments to evaluate menopausal symptoms; however, no cut-off score is given that would indicate the need for treatment. Our goal was to determine such a cut-off score on the MRS, using as a standard a woman's own perception of her need for treatment in relation to the severity of her symptoms. MATERIAL AND METHODS: The sample comprised 427 healthy women aged 40-59 years who were not taking hormonal treatment...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29670824/characterization-of-brain-anatomical-patterns-by-comparing-region-intensity-distributions-applications-to-the-description-of-alzheimer-s-disease
#13
Diana L Giraldo, Juan D García-Arteaga, Simón Cárdenas-Robledo, Eduardo Romero
Purpose: This work presents an automatic characterization of the Alzheimer's disease describing the illness as a multidirectional departure from a baseline defining the control state, being these directions determined by a distance between functional-equivalent anatomical regions. Methods: After a brain parcellation, a region is described by its histogram of gray levels, and the Earth mover's distance establishes how close or far these regions are. The medoid of the control group is set as the reference and any brain is characterized by its set of distances to this medoid...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29666170/serum-25-hydroxyvitamin-d-levels-throughout-pregnancy-a-longitudinal-study-in-healthy-and-preeclamptic-pregnant-women
#14
Yessica Agudelo-Zapata, Luis Miguel Maldonado-Acosta, Hector Fabio Sandoval-Alzate, Natalia Elvira Poveda, María Fernanda Garcés, Jonathan Alexander Cortés-Vásquez, Andrés Felipe Linares-Vaca, Carlos Alejandro Mancera-Rodríguez, Shahar Alexandra Perea-Ariza, Karen Yuliana Ramírez-Iriarte, Camilo Andrés Castro-Saldarriaga, Juan Manuel Arteaga-Diaz, Roberto Franco-Vega, Edith Angel-Muller, Arturo José Parada-Baños, Jorge Eduardo Caminos
BACKGROUND: Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency, and has been associated with adverse outcomes during pregnancy. OBJECTIVE: This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 preeclamptic women and 61 healthy pregnant women. An additional group of 29 healthy non-pregnant women were also studied during the two phases of the menstrual cycle...
April 17, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29659362/-recurrent-atypical-hemolytic-uremic-syndrome-after-renal-transplantation-treatment-with-eculizumab
#15
Ana B Latzke, Pehuén Fernández, Carlos Chiurchiu, Daniela Sarmantano, Javier De Arteaga, Walter Douthat, Jorge De la Fuente
Atypical hemolytic uremic syndrome (aHUS) is a rare entity. It is characterized by a thrombotic microangiopathy (nonimmune hemolytic anemia, thrombocytopenia, and acute renal failure), with a typical histopathology of thickening of capillary and arteriolar walls and an obstructive thrombosis of the vascular lumen. The syndrome is produced by a genetic or acquired deregulation of the alternative pathway of the complement system, with high rates of end stage renal disease, post-transplant recurrence, and high mortality...
2018: Medicina
https://www.readbyqxmd.com/read/29617771/real-time-dna-barcoding-in-a-rainforest-using-nanopore-sequencing-opportunities-for-rapid-biodiversity-assessments-and-local-capacity-building
#16
Aaron Pomerantz, Nicolás Peñafiel, Alejandro Arteaga, Lucas Bustamante, Frank Pichardo, Luis A Coloma, César L Barrio-Amorós, David Salazar-Valenzuela, Stefan Prost
Background: Advancements in portable scientific instruments provide promising avenues to expedite field work in order to understand the diverse array of organisms that inhabit our planet. Here, we tested the feasibility for in situ molecular analyses of endemic fauna using a portable laboratory fitting within a single backpack, in one of the world's most imperiled biodiversity hotspots: the Ecuadorian Chocó rainforest. We utilized portable equipment, including the MinION nanopore sequencer (Oxford Nanopore Technologies) and the miniPCR (miniPCR), to perform DNA extraction, PCR amplification and real-time DNA barcoding of reptile specimens in the field...
April 2, 2018: GigaScience
https://www.readbyqxmd.com/read/29581135/er-breast-cancers-resistant-to-prolonged-neoadjuvant-letrozole-exhibit-an-e2f4-transcriptional-program-sensitive-to-cdk4-6-inhibitors
#17
Angel Guerrero-Zotano, Thomas Stricker, Luigi Formisano, Katherine E Hutchinson, Daniel G Stover, Kyung-Min Lee, Luis J Schwarz, Jennifer M Giltnane, Monica V Estrada, Valerie M Jansen, Alberto Servetto, Joaquín Gavilá, José Alejandro Pérez-Fidalgo, Ana Lluch, Antonio Llombart-Cussac, Mohamed Amine Bayar, Stefan Michiels, Fabrice Andre, Monica Arnedos, Vicente Guillem, Amparo Ruiz-Simon, Carlos L Arteaga
PURPOSE: This study aimed to identify biomarkers of resistance to endocrine therapy in ER+ breast cancers (BC) treated with prolonged neoadjuvant letrozole. Experimental Design: We performed targeted DNA and RNA-sequencing in 68 ER+ BC from patients treated with preoperative letrozole (median 7 months). Results:Twenty-four tumors (35%) exhibited a PEPI score ≥4 and/or recurred after a median of 58 months and were considered endocrine resistant. Integration of the 47 most upregulated genes (log FC>1, FDR<0...
March 26, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29579094/abdominal-obesity-is-a-common-finding-in-normal-and-overweight-subjects-of-chile-and-is-associated-with-increased-frequency-of-cardiometabolic-risk-factors
#18
Beatriz Villanueva, Antonio Arteaga, Alberto Maiz, Víctor A Cortés
BACKGROUND/OBJECTIVES: Abdominal obesity (AO) is associated with elevated risk for cardiovascular diseases; however, this association is less clear for non-obese people. We estimated the association of AO and cardiovascular risk factors (CVRF) and disease in non-obese adult individuals from Chile. SUBJECTS/METHODS: 5248 adults (15 years of age or older) of both sexes from the Chilean National Health Survey (October 2009 -September 2010, response rate 85%.) were included...
2018: PloS One
https://www.readbyqxmd.com/read/29575779/accumulating-data-to-optimally-predict-obesity-treatment-adopt-core-measures-environmental-domain
#19
Brian E Saelens, S Sonia Arteaga, David Berrigan, Rachel M Ballard, Amy A Gorin, Tiffany M Powell-Wiley, Charlotte Pratt, Jill Reedy, Shannon N Zenk
BACKGROUND: There is growing interest in how environment is related to adults' weight and activity and eating behaviors. However, little is known about whether environmental factors are related to the individual variability seen in adults' intentional weight loss or maintenance outcomes. OBJECTIVES: The environmental domain subgroup of the Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Project sought to identify a parsimonious set of objective and perceived neighborhood and social environment constructs and corresponding measures to include in the assessment of response to adult weight-loss treatment...
April 2018: Obesity
https://www.readbyqxmd.com/read/29520809/genome-wide-signatures-of-flowering-adaptation-to-climate-temperature-regional-analyses-in-a-highly-diverse-native-range-of-arabidopsis-thaliana
#20
Daniel Tabas-Madrid, Belén Méndez-Vigo, Noelia Arteaga, Arnald Marcer, Alberto Pascual-Montano, Detlef Weigel, F Xavier Picó, Carlos Alonso-Blanco
Current global change is fueling an interest to understand the genetic and molecular mechanisms of plant adaptation to climate. In particular, altered flowering time is a common strategy for escape from unfavourable climate temperature. In order to determine the genomic bases underlying flowering time adaptation to this climatic factor, we have systematically analysed a collection of 174 highly diverse Arabidopsis thaliana accessions from the Iberian Peninsula. Analyses of 1.88 million single nucleotide polymorphisms provide evidence for a spatially heterogeneous contribution of demographic and adaptive processes to geographic patterns of genetic variation...
March 8, 2018: Plant, Cell & Environment
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