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https://www.readbyqxmd.com/read/28720316/pigeons-and-their-droppings-as-reservoirs-of-candida-and-other-zoonotic-yeasts
#1
Inmaculada Rosario Medina, Lorena Román Fuentes, Miguel Batista Arteaga, Fernando Real Valcárcel, Félix Acosta Arbelo, Daniel Padilla Del Castillo, Soraya Déniz Suárez, Otilia Ferrer Quintana, Belinda Vega Gutiérrez, Freddy Silva Sergent, Begoña Acosta-Hernández
BACKGROUND: The importance of pigeons as reservoirs and carriers of Cryptococcus neoformans and other species of this genus is well-known; however, less is known about their role as reservoirs and carriers of other yeasts that impact public health. AIMS: The present study was performed on Gran Canaria Island to define yeasts other than Cryptococcus spp. that have been reported to impact public health and which could be carried by pigeons. METHODS: Samples were obtained from 83 pigeon lofts (Columba livia); moreover, 331 crop samples, 331 cloacal samples and 174 dropping samples were collected...
July 15, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28706147/tumor-p38mapk-signaling-enhances-breast-carcinoma-vascularization-and-growth-by-promoting-expression-and-deposition-of-pro-tumorigenic-factors
#2
Michelle Limoge, Alfiya Safina, Alexander M Truskinovsky, Ieman Aljahdali, Justin Zonneville, Aleksandar Gruevski, Carlos L Arteaga, Andrei V Bakin
The breast carcinoma microenvironment strikingly influences cancer progression and response to therapy. Various cell types in the carcinoma microenvironment show significant activity of p38 mitogen-activated protein kinase (MAPK), although the role of p38MAPK in breast cancer progression is still poorly understood. The present study examined the contribution of tumor p38MAPK to breast carcinoma microenvironment and metastatic capacity. Inactivation of p38MAPK signaling in metastatic breast carcinoma cells was achieved by forced expression of the kinase-inactive mutant of p38/MAPK14 (a dominant-negative p38, dn-p38)...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696691/electronic-and-functional-scope-of-boronic-acid-derived-salicylidenehydrazone-bashy-complexes-as-fluorescent-dyes
#3
María M Alcaide, Fabio M F Santos, Vânia F Pais, Joana Inês Carvalho, Daniel Collado, Ezequiel Pérez-Inestrosa, Jesús F Arteaga, Francisco Boscá, Pedro M P Gois, Uwe Pischel
A series of boronic acid derived salicylidenehydrazone (BASHY) complexes was prepared and photophysically characterized. The dye platform can be modified by (a) electronic tuning along the cyanine-type axis via modification of the donor-acceptor pair and (b) functional tuning via the boronic acid residue. On the one hand, approach (a) allows the control of photophysical parameters such as Stokes shift, emission color, and two-photon-absorption (2PA) cross section. The resulting dyes show emission light-up behavior in nonpolar media and are characterized by high fluorescence quantum yields (ca...
July 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28688728/community-policies-and-programs-to-prevent-obesity-and-child-adiposity
#4
Edward A Frongillo, Stephen B Fawcett, Lorrene D Ritchie, S Sonia Arteaga, Catherine M Loria, Russell R Pate, Lisa V John, Warren J Strauss, Maria Gregoriou, Vicki L Collie-Akers, Jerry A Schultz, Andrew J Landgraf, Jyothi Nagaraja
INTRODUCTION: Evidence regarding impact of community policies and programs (CPPs) to prevent child obesity is limited, and which combinations of strategies and components are most important is not understood. The Healthy Communities Study was an observational study to assess relationships of characteristics and intensity of CPPs with adiposity, diet, and physical activity in children, taking advantage of variation across the U.S. in community actions to prevent child obesity. The study examined the association of CPPs to prevent child obesity with measured BMI and waist circumference, hypothesizing that communities with more-comprehensive CPPs would have children with lower adiposity...
July 5, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28687931/differential-cellular-immune-response-of-galleria-mellonella-to-actinobacillus-pleuropneumoniae
#5
Luis Andrés Arteaga Blanco, Josicelli Souza Crispim, Kenner Morais Fernandes, Leandro Licursi de Oliveira, Monalessa Fábia Pereira, Denise Mara Soares Bazzolli, Gustavo Ferreira Martins
In the present work, we have investigate the cellular immune response of Galleria mellonella larvae against three strains of the gram-negative bacterium Actinobacillus pleuropneumoniae: low-virulence (780), high-virulence (1022) and the serotype 8 reference strain (R8). Prohemocytes, plasmatocytes, granulocytes, oenocytoids and spherulocytes were distinguished according to their size and morphology, their molecular markers and dye-staining properties and their role in the immune response. Total hemocyte count, differential hemocyte count, lysosome activity, autophagic response, cell viability and caspase-3 activation were determined in circulating hemocytes of naive and infected larvae...
July 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28672088/photocaged-competitor-guests-a-general-approach-toward-light-activated-cargo-release-from-cucurbiturils
#6
Miguel A Romero, Nuno Basilio, Artur J Moro, Mara Domingues, José A González-Delgado, Jesús F Arteaga, Uwe Pischel
A general approach toward the light-induced guest release from cucurbit[7]uril by means of a photoactivatable competitor was devised. An o-nitrobenzyl-caged competitor is photolyzed to generate a competitive guest that can displace cargo from the host macrocycle solely based on considerations of chemical equilibrium. With this tool the release of terpene guests from inclusion complexes with cucurbit[7]uril was demonstrated. The binding of the herein investigated terpenes, all being lead fragrant components in essential oils, has been characterized for the first time...
July 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28666526/-comparison-of-results-of-open-simple-nephrectomy-secondary-to-lithiasis-in-patients-with-and-without-nephrostomy
#7
Luis Daniel Carrillo-Córdova, Jean Manuel Jiménez-Villavicencio, Jhonatan Vitar-Sandoval, Roberto Carlos Sarabia-Estrada, Hugo Rivera-Astorga, Gerardo Rodrigo Lemus-Mena, Eduardo Sánchez-Meza, Jorge Raul Carrillo-Córdova, Eli Jalil Camilo-Martínez, Alejandro Rosas-Ramírez, José Francisco Virgen-Gutiérrez, Jorge Jaspersen-Gastelum, Mateo Leopoldo Garduño-Arteaga
BACKGROUND: Simple nephrectomy is the procedure of choice in the treatment of excluded kidneys. The purpose of this study was to describe and compare surgical results in open simple retroperitoneal nephrectomies in patients with and without nephrostomy. METHODOLOGY: 58 patients were analyzed. The demographic parameters of patients with nephrostomy were compared to patients without nephrostomy (age, gender, weight, lithium localization, transoperative variables (surgical time, transoperative bleeding) and postoperative variables (need for intensive care, need for transfusion, surgical wound infection and hospital stay days) RESULTS: Statistically significant differences were found for the variables of operative bleeding (p=0...
June 27, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28645201/benznidazole-treatment-safety-the-m%C3%A3-decins-sans-fronti%C3%A3-res-experience-in-a-large-cohort-of-bolivian-patients-with-chagas-disease
#8
Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Alejandro Marcel Hasslocher-Moreno, Marcelo Teixeira de Holanda, Andrea Silvestre de Sousa, Luiz Henrique Conde Sangenis, Pedro Emmanuel Alvarenga Americano do Brasil, Roger Arteaga Mejía, Carina Perotti Fux, Juan-Carlos Cubides, Roberto Magalhães Saraiva, Lucia Maria Brum-Soares
Background: Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment. Objectives: To verify the incidence and possible factors associated with the suspension of benznidazole treatment in a large cohort of patients. Methods: We included 2075 patients treated with benznidazole during the projects managed by the medical humanitarian organization Doctors Without Borders (Médecins Sans Frontières) in Bolivia from 2009 to 2013...
June 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28627211/consumo-de-huevo-y-enfermedad-cardiovascular-una-revisi%C3%A3-n-de-la-literatura-cient%C3%A3-fica
#9
Catalina Dussaillant, Guadalupe Echeverría, Jaime Rozowski, Nicolás Velasco, Antonio Arteaga, Attilio Rigotti
El huevo es un alimento que aporta proteína de alta calidad y numerosos nutrientes con potenciales beneficios para la salud. Sin embargo, la aparición de la enfermedad cardiovascular como importante causa de morbilidad y mortalidad en el mundo, junto con la identificación de los niveles elevados de colesterol plasmático como factor de riesgo para esta patología, llevó, en los años 70, a profesionales e instituciones de salud a limitar el consumo de colesterol y, por tanto, de huevo en la población. Hasta la fecha, los análisis de cohortes prospectivas tienden a mostrar que el consumo de hasta un huevo diario no aumenta significativamente el riesgo cardiovascular en la población sana...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28599955/inequities-in-visual-health-and-health-services-use-in-a-rural-region-in-spain
#10
Sergio Latorre-Arteaga, José Fernández-Sáez, Diana Gil-González
OBJECTIVE: To analyse perceived visual health and health services use in a rural population in relation to socioeconomic characteristics and compared with the general population in Spain. METHOD: Cross-sectional study in a rural population using a structured questionnaire including questions comparable to the Spanish National Health Survey (2012). A descriptive analysis was carried out through the calculation of frequencies and prevalence, the χ(2) test for independent variables, contrasts of proportions and logistic regression to obtain associations between the rural and general populations and socioeconomic variables...
June 6, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28589974/multifunctional-catalysis-stereoselective-construction-of-%C3%AE-methylidene-%C3%AE-lactams-via-an-amidation-rauhut-currier-sequence
#11
Kenta Kishi, Fernando Arteaga Arteaga, Shinobu Takizawa, Hiroaki Sasai
Mixing of acryloylchloride, dienone 2, N,N-diisopropylethylamine with chiral organocatalyst 5a, which could simultaneously act as Brønsted and Lewis base catalysts, led to a one-pot amidation/Rauhut-Currier sequence, affording α-methylidene-γ-lactams 4. Catalyst 5a could be recovered and reused by acid/base extraction without any loss of catalytic activity in the stepwise protocol.
July 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28576675/buparlisib-plus-fulvestrant-versus-placebo-plus-fulvestrant-in-postmenopausal-hormone-receptor-positive-her2-negative-advanced-breast-cancer-belle-2-a-randomised-double-blind-placebo-controlled-phase-3-trial
#12
José Baselga, Seock-Ah Im, Hiroji Iwata, Javier Cortés, Michele De Laurentiis, Zefei Jiang, Carlos L Arteaga, Walter Jonat, Mark Clemons, Yoshinori Ito, Ahmad Awada, Stephen Chia, Agnieszka Jagiełło-Gruszfeld, Barbara Pistilli, Ling-Ming Tseng, Sara Hurvitz, Norikazu Masuda, Masato Takahashi, Peter Vuylsteke, Soulef Hachemi, Bharani Dharan, Emmanuelle Di Tomaso, Patrick Urban, Cristian Massacesi, Mario Campone
BACKGROUND: Phosphatidylinositol 3-kinase (PI3K) pathway activation is a hallmark of endocrine therapy-resistant, hormone receptor-positive breast cancer. This phase 3 study assessed the efficacy of the pan-PI3K inhibitor buparlisib plus fulvestrant in patients with advanced breast cancer, including an evaluation of the PI3K pathway activation status as a biomarker for clinical benefit. METHODS: The BELLE-2 trial was a randomised, double-blind, placebo-controlled, multicentre study...
May 30, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28574604/boosting-the-snr-by-adding-a-receive-only-endorectal-monopole-to-an-external-antenna-array-for-high-resolution-t2-weighted-imaging-of-early-stage-cervical-cancer-with-7-t-mri
#13
I M L van Kalleveen, J P Hoogendam, A J E Raaijmakers, F Visser, C S Arteaga de Castro, R H M Verheijen, P R Luijten, R P Zweemer, W B Veldhuis, D W J Klomp
The aim of this study was to investigate the signal-to-noise ratio (SNR) gain in early-stage cervical cancer at ultrahigh-field MRI (e.g. 7 T) using a combination of multiple external antennas and a single endorectal antenna. In particular, we used an endorectal monopole antenna to increase the SNR in cervical magnetic resonance imaging (MRI). This should allow high-resolution, T2 -weighted imaging and magnetic resonance spectroscopy (MRS) for metabolic staging, which could facilitate the local tumor status assessment...
June 2, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28573007/depth-dependent-effects-of-culling-do-mesophotic-lionfish-populations-undermine-current-management
#14
Dominic A Andradi-Brown, Rachel Grey, Alicia Hendrix, Drew Hitchner, Christina L Hunt, Erika Gress, Konrad Madej, Rachel L Parry, Catriona Régnier-McKellar, Owen P Jones, María Arteaga, Andrea P Izaguirre, Alex D Rogers, Dan A Exton
Invasive lionfish (Pterois volitans and P. miles) have spread widely across the western Atlantic and are recognized as a major threat to native marine biodiversity. Although lionfish inhabit both shallow reefs and mesophotic coral ecosystems (MCEs; reefs from 30 to 150 m depth), the primary management response implemented by many countries has been diver-led culling limited to reefs less than 30 m. However, many reef fish undergo ontogenetic migrations, with the largest and therefore most fecund individuals found at greatest depths...
May 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28567707/anaerobic-digestion-of-amine-oxide-based-surfactants-biodegradation-kinetics-and-inhibitory-effects
#15
Francisco Ríos, Manuela Lechuga, Alejandro Fernández-Arteaga, Encarnación Jurado, Mercedes Fernández-Serrano
Recently, anaerobic degradation has become a prevalent alternative for the treatment of wastewater and activated sludge. Consequently, the anaerobic biodegradability of recalcitrant compounds such as some surfactants require a thorough study to avoid their presence in the environment. In this work, the anaerobic biodegradation of amine-oxide-based surfactants, which are toxic to several organisms, was studied by measuring of the biogas production in digested sludge. Three amine-oxide-based surfactants with structural differences in their hydrophobic alkyl chain were tested: Lauramine oxide (AO-R12), Myristamine oxide (AO-R14) and Cocamidopropylamine oxide (AO-cocoamido)...
May 31, 2017: Biodegradation
https://www.readbyqxmd.com/read/28539475/the-brain-microenvironment-mediates-resistance-in-luminal-breast-cancer-to-pi3k-inhibition-through-her3-activation
#16
David P Kodack, Vasileios Askoxylakis, Gino B Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Z Alexander Cao, Rakesh R Ramjiawan, Divya Bezwada, Bhushankumar Patel, Yongchul Song, Carlotta Costa, Kamila Naxerova, Christina S F Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G Duda, C Ryan Miller, Marni B Siegel, Carey K Anders, Melinda Sanders, Monica V Estrada, Robert Schlegel, Carlos L Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A Engelman, Rakesh K Jain
Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed that brain metastases evade phosphatidylinositide 3-kinase (PI3K) inhibition despite drug accumulation in the brain lesions. In comparison to extracranial disease, we observed increased HER3 expression and phosphorylation in brain lesions. HER3 blockade overcame the resistance of HER2-amplified and/or PIK3CA-mutant breast cancer brain metastases to PI3K inhibitors, resulting in marked tumor growth delay and improvement in mouse survival...
May 24, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28495849/neoadjuvant-trials-in-er-breast-cancer-a-tool-for-acceleration-of-drug-development-and-discovery
#17
REVIEW
Angel L Guerrero-Zotano, Carlos L Arteaga
Neoadjuvant therapy trials offer an excellent strategy for drug development and discovery in breast cancer, particularly in triple-negative and HER2-overexpressing subtypes, where pathologic complete response is a good surrogate of long-term patient benefit. For estrogen receptor-positive (ER(+)) breast cancers, however, use of this strategy has been challenging because of the lack of validated surrogates of long-term efficacy and the overall good prognosis of the majority of patients with this cancer subtype...
June 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28474711/-case-report-disseminated-cutaneous-leishmaniasis-lcd
#18
Alexandra Mancheno-Valencia, Julia Cabezas-Arteaga, Ketty Sacoto-Aizaga, Roberto Arenas-Guzmáno
The World Health Organization (WHO) has classified leishmaniasis as an uncontrolled and emerging disease. In Ecuador, the only anecdotal cases of diffuse cutaneous leishmaniasis were recorded in 1994 and have not been formally published. This form can be differentiated from classical localized cutaneous leishmaniasis by the number of injuries, the clinical type of the main elementary lesions (papular and acneform), and a weak response to standard treatments. The case we report is a 34-year-old woman who presented with disseminated nodular lesions and ulcers of various sizes with erythematous edges and scars...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28464366/healthcare-resource-utilization-and-cost-among-males-with-lower-urinary-tract-symptoms-with-a-predominant-storage-component-in-spain-the-epidemiological-cross-sectional-mercury-study
#19
Carlos Errando-Smet, Carlos Müller-Arteaga, Marta Hernández, Enrique Lenero, Montse Roset
AIMS: To assess the relationship between storage-predominant LUTS and healthcare resource consumption and cost among males in Spain. METHODS: In this non-interventional, cross-sectional study, urologists enrolled males with storage-predominant LUTS and recorded the consumption of healthcare resources (medical visits, diagnostic tests/monitoring, treatment, and hospitalizations) within the previous 6 months. The cost of healthcare resources was calculated from unit costs extracted from a Spanish eHealth database...
May 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28463216/-inadequate-doses-of-hemodialysis-predisposing-factors-causes-and-prevention
#20
Pehuén Fernández, Silvana Núñez, Javier De Arteaga, Carlos Chiurchiu, Walter Douthat, Jorge De La Fuente
Patients receiving sub-optimal dose of hemodialysis have increased morbidity and mortality. The objectives of this study were to identify predisposing factors and causes of inadequate dialysis, and to design a practical algorithm for the management of these patients. A cross-sectional study was conducted. Ninety patients in chronic hemodialysis at Hospital Privado Universitario de Córdoba were included, during September 2015. Twenty two received sub-optimal dose of hemodialysis. Those with urea distribution volume (V) greater than 40 l (72 kg body weight approximately) are 11 times more likely (OR = 11...
2017: Medicina
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