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Feixiong Cheng, Junfei Zhao, Ariella B Hanker, Monica Red Brewer, Carlos L Arteaga, Zhongming Zhao
PURPOSE: Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in human breast cancer. Furthermore, PIK3CA mutations are commonly associated with resistance to anti-epidermal growth factor receptor 2 (HER2) or anti-estrogen receptor (ER) agents in HER2 or ER positive (HER2(+)/ER(+)) breast cancer. Hence, deciphering the underlying mechanisms of PIK3CA mutations in HER2(+)/ER(+) breast cancer would provide novel insights into elucidating resistance to anti-HER2/ER therapies...
October 22, 2016: Breast Cancer Research and Treatment
Manasi Hulyalkar, Stephen J Gleich, Rahul Kashyap, Amelia Barwise, Harsheen Kaur, Yue Dong, Lei Fan, Srinivas Murthy, Grace M Arteaga, Sandeep Tripathi
Increasing process complexity in the pediatric intensive care unit (PICU) can lead to information overload resulting in missing pertinent information and potential errors during morning rounds. An efficient model using a novel electronic rounding tool was designed as part of a broader critical care decision support system-checklist for early recognition and treatment of acute illness and injury in pediatrics (CERTAINp). We aimed to evaluate its impact on improving the process of care during rounding. Prospective pre- and post-interventional data included: team performance baseline assessment, patient safety discussion, guideline adherence, rounding time, and a survey of Residents' and Nurses' perception using a Likert scale...
October 18, 2016: Journal of Clinical Monitoring and Computing
Artur Carnicer, Oriol Arteaga, Josep M Suñé-Negre, Bahram Javidi
The counterfeiting of pharmaceutical products represents concerns for both industry and the safety of the general public. Falsification produces losses to companies and poses health risks for patients. In order to detect fake pharmaceutical tablets, we propose producing film-coated tablets with gold nanoparticle encoding. These coated tablets contain unique polarimetric signatures. We present experiments to show that ellipsometric optical techniques, in combination with machine learning algorithms, can be used to distinguish genuine and fake samples...
October 1, 2016: Optics Letters
Alicia Sánchez-Gorostiaga, Pilar Palacios, Rocío Martínez-Arteaga, Manuel Sánchez, Mercedes Casanova, Miguel Vicente
: When deprived of FtsZ, Escherichia coli cells (VIP205) grown in liquid form long nonseptated filaments due to their inability to assemble an FtsZ ring and their failure to recruit subsequent divisome components. These filaments fail to produce colonies on solid medium, in which synthesis of FtsZ is induced, upon being diluted by a factor greater than 4. However, once the initial FtsZ levels are recovered in liquid culture, they resume division, and their plating efficiency returns to normal...
October 11, 2016: MBio
Gabriel N Hortobagyi, Salomon M Stemmer, Howard A Burris, Yoon-Sim Yap, Gabe S Sonke, Shani Paluch-Shimon, Mario Campone, Kimberly L Blackwell, Fabrice André, Eric P Winer, Wolfgang Janni, Sunil Verma, Pierfranco Conte, Carlos L Arteaga, David A Cameron, Katarina Petrakova, Lowell L Hart, Cristian Villanueva, Arlene Chan, Erik Jakobsen, Arnd Nusch, Olga Burdaeva, Eva-Maria Grischke, Emilio Alba, Erik Wist, Norbert Marschner, Anne M Favret, Denise Yardley, Thomas Bachelot, Ling-Ming Tseng, Sibel Blau, Fengjuan Xuan, Farida Souami, Michelle Miller, Caroline Germa, Samit Hirawat, Joyce O'Shaughnessy
Background The inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) could potentially overcome or delay resistance to endocrine therapy in advanced breast cancer that is positive for hormone receptor (HR) and negative for human epidermal growth factor receptor 2 (HER2). Methods In this randomized, placebo-controlled, phase 3 trial, we evaluated the efficacy and safety of the selective CDK4/6 inhibitor ribociclib combined with letrozole for first-line treatment in 668 postmenopausal women with HR-positive, HER2-negative recurrent or metastatic breast cancer who had not received previous systemic therapy for advanced disease...
October 7, 2016: New England Journal of Medicine
Aníbal Enrique Roldán-Rodríguez, Erick Joel Vega-Quispe, Isabel Silva-Ocas, Kevin Edward Lemus-Arteaga, Jaime Gilberto Gonzales-Saldaña, Franklyn Norwich Ruiz-Urbina, Iván Freddy Urtecho-Gaitan, Víctor Edwin Zamora-Mostacero, Juan Edder Vargas-Ferrer, Gillmari Juliza Valverde-Quezada, Kevin Oswaldo Vásquez-Sandoval, Juan Jorge Huamán-Saavedra
OBJECTIVE: To determine the effect of treatment with honey in piroxicam-induced gastric ulcer in Holtzman rats. MATERIALS AND METHODS: 48 eight-week old female Holtzman rats, weights between 100 and 200 grams, were divided into 6 treatment groups as follow: Group A: water; Group B: piroxicam (30 mg/kg); Group C: omeprazole (5 mg/kg) and piroxicam (30 mg/kg); Group D: honey (2.5 g/kg) and piroxicam (30 mg/kg); Group E: honey (5 g/kg) and piroxicam (30 mg/kg); Group F: honey (7...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Sergio Latorre-Arteaga, Diana Gil-González, Covadonga Bascarán, Richard Hurtado Núñez, María Del Carmen Peral Morales, Guillermo Carrillo Orihuela
OBJECTIVE: To describe the adaptation and scaling-up of an intervention to improve the visual health of children in the Apurimac region, Peru. METHODS: In a pilot screening programme in 2009-2010, 26 schoolteachers were trained to detect and refer visual acuity problems in schoolchildren in one district in Apurimac. To scale-up the intervention, lessons learnt from the pilot were used to design strategies for: (i) strengthening multisector partnerships; (ii) promoting the engagement and participation of teachers and (iii) increasing children's attendance at referral eye clinics...
September 1, 2016: Bulletin of the World Health Organization
Karina Banda-R, Alfonso Delgado-Salinas, Kyle G Dexter, Reynaldo Linares-Palomino, Ary Oliveira-Filho, Darién Prado, Martin Pullan, Catalina Quintana, Ricarda Riina, Gina M Rodríguez M, Julia Weintritt, Pedro Acevedo-Rodríguez, Juan Adarve, Esteban Álvarez, Anairamiz Aranguren B, Julián Camilo Arteaga, Gerardo Aymard, Alejandro Castaño, Natalia Ceballos-Mago, Álvaro Cogollo, Hermes Cuadros, Freddy Delgado, Wilson Devia, Hilda Dueñas, Laurie Fajardo, Ángel Fernández, Miller Ángel Fernández, Janet Franklin, Ethan H Freid, Luciano A Galetti, Reina Gonto, Roy González-M, Roger Graveson, Eileen H Helmer, Álvaro Idárraga, René López, Humfredo Marcano-Vega, Olga G Martínez, Hernán M Maturo, Morag McDonald, Kurt McLaren, Omar Melo, Francisco Mijares, Virginia Mogni, Diego Molina, Natalia Del Pilar Moreno, Jafet M Nassar, Danilo M Neves, Luis J Oakley, Michael Oatham, Alma Rosa Olvera-Luna, Flávia F Pezzini, Orlando Joel Reyes Dominguez, María Elvira Ríos, Orlando Rivera, Nelly Rodríguez, Alicia Rojas, Tiina Särkinen, Roberto Sánchez, Melvin Smith, Carlos Vargas, Boris Villanueva, R Toby Pennington
Seasonally dry tropical forests are distributed across Latin America and the Caribbean and are highly threatened, with less than 10% of their original extent remaining in many countries. Using 835 inventories covering 4660 species of woody plants, we show marked floristic turnover among inventories and regions, which may be higher than in other neotropical biomes, such as savanna. Such high floristic turnover indicates that numerous conservation areas across many countries will be needed to protect the full diversity of tropical dry forests...
September 23, 2016: Science
R Alexander Pyron, Alejandro Arteaga, Lourdes Y Echevarría, Omar Torres-Carvajal
The genus Synophis contains a number of enigmatic species, distributed primarily in the Andean highlands of northern South America. Their extreme crypsis and rarity has precluded detailed study of most species. A recent flurry of collection activity resulted in the accession of many new specimens, and the description of 4 new species in 2015, doubling the number of described taxa. However, lingering questions remain regarding the assignment of many new and historical specimens, the morphological limits and geographical ranges of the species, and their phylogenetic relationships...
September 28, 2016: Zootaxa
Na Shang, Maribel Arteaga, Lennox Chitsike, Fang Wang, Navin Viswakarma, Peter Breslin, Wei Qiu
: Understanding the molecular mechanisms of liver regeneration is essential to improve the survival rate of patients after surgical resection of large amounts of liver tissue. Focal adhesion kinase (FAK) regulates different cellular functions, including cell survival, proliferation and cell migration. The role of FAK in liver regeneration remains unknown. In this study, we found that Fak is activated and induced during liver regeneration after two-thirds partial hepatectomy (PHx). We used mice with liver-specific deletion of Fak and investigated the role of Fak in liver regeneration in 2/3 PHx model (removal of 2/3 of the liver)...
September 28, 2016: Scientific Reports
Lander Gallego Otaegui, Aitor Sainz Lete, Rodrigo David Gutiérrez Ríos, Maialen Alkorta Zuloaga, Xabier Arteaga Martín, Raúl Jiménez Agüero, Miguel Ángel Medrano Gómez, Inmaculada Ruiz Montesinos, Adolfo Beguiristain Gómez
CT images and endoscopic findings in a case of Bouveret's syndrome.
July 2016: Revista Española de Enfermedades Digestivas
Sergio Latorre-Arteaga, Diana Gil-González, Carmen Vives-Cases, Daniel La Parra Casado
We analyzed vision and hearing health status in the Spanish Roma population compared with the general population and its influence on mental health and social participation. We conducted a Cross-sectional study on Roma population (n = 1.167) compared to general population in Spain (n = 21.007). We analyzed the use of optical and hearing aids, vision and hearing limitations and associations with mental health, diagnosed depression and social participation; through prevalence, odds ratio adjusted by age (AOR), Chi square independence test and contrast of proportions (p < 0...
September 20, 2016: Journal of Immigrant and Minority Health
Martha C Mayorquín-Torres, Rafael Arcos-Ramos, Marcos Flores-Álamo, Martín A Iglesias-Arteaga
Crystalline derivatives of side chain modified bile acids were efficiently prepared from the naturally occurring steroids by palladium-catalyzed cross coupling reaction as a key step. The solvent-free crystalline bile acids derivatives 2b-e are readily accessed by slow evaporation from selected solvents. A variety of steroidal scaffolds were found and elucidated by SXRD studies. The crystal packing of the title compounds are dominated by hydrogen-bonding interactions established between differently positioned acetyl protecting groups, which in the case of 2b and 2e take advantage of the facial amphiphilicity producing two novel steroidal supramolecular self-assemblies combining π-π and strong facial interactions...
November 2016: Steroids
Lyda Espitia-Pérez, Milton Quintana Sosa, Shirley Salcedo-Arteaga, Grethel León-Mejía, Luz Stella Hoyos-Giraldo, Hugo Brango, Katia Kvitko, Juliana da Silva, João A P Henriques
Increasing evidence suggest that occupational exposure to open-cast coal mining residues like dust particles, heavy metals and Polycyclic Aromatic Hydrocarbons (PAHs) may cause a wide range of DNA damage and genomic instability that could be associated to initial steps in cancer development and other work-related diseases. The aim of our study was to evaluate if key polymorphisms in metabolism genes CYP1A1Msp1, GSTM1Null, GSTT1Null and DNA repair genes XRCC1Arg194Trp and hOGG1Ser326Cys could modify individual susceptibility to adverse coal exposure effects, considering the DNA damage (Comet assay) and micronucleus formation in lymphocytes (CBMN) and buccal mucosa cells (BMNCyt) as endpoints for genotoxicity...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
D Natera-de Benito, J Domínguez-Carral, N Muelas, A Nascimento, C Ortez, T Jaijo, R Arteaga, J Colomer, J J Vilchez
Congenital myasthenic syndromes (CMS) are a heterogeneous group of genetic disorders. Mutations in CHRNE are one of the most common cause of them and the ɛ1267delG frameshifting mutation is described to be present on at least one allele of 60% of patients with CHRNE mutations. We present a comprehensive description of the heterogeneous clinical features of the CMS caused by the homozygous 1267delG mutation in the AChR Ɛ subunit in nine members of two large Gipsy kindreds. Our observations indicate that founder Roma mutation 1267delG leads to a phenotype further characterized by ophthalmoplegia, bilateral ptosis, and good response to pyridostigmine and 3,4-DAP; but also by facial weakness, bulbar symptoms, neck muscle weakness, and proximal limb weakness that sometimes entails the loss of ambulation...
August 15, 2016: Neuromuscular Disorders: NMD
Miguel Angel Palomero-Rodríguez, Héctor Chozas de Arteaga, Yolanda Laporta Báez, Jesús de Vicente Sánchez, Pascual Sanabria Carretero, Pilar Sánchez Conde, Antonio Pérez Ferrer
BACKGROUND: Over the last years, we have used a flow-inflating bag circuit with a nasotracheal or nasopharyngeal tube as an interface to deliver effective CPAP support in infants ("Mapleson D CPAP system"). The primary goal of this study was to assess the usefulness of the "Mapleson D CPAP system" for weaning of mechanical ventilation (MV) in infants who received MV over 24 h. MATERIALS AND METHODS: All infants who received MV for more than 24 h in the last year were enrolled in the study...
September 2016: Lung India: Official Organ of Indian Chest Society
Gloria Cordoba, Lidia Caballero, Håkon Sandholdt, Fátima Arteaga, Monica Olinisky, Luis Fabián Ruschel, Marjukka Makela, Lars Bjerrum
OBJECTIVES: To describe and compare antibiotic prescribing patterns for primary care patients with respiratory tract infections (RTIs) in four South American countries. METHODS: This was a prospective observational study. General practitioners (GPs) from Argentina, Bolivia, Paraguay and Uruguay registered data about all consultations of patients with suspected RTIs in the winter of 2014 (June-August). Variation in antibiotic prescriptions was assessed using a two-level hierarchical logistic model...
September 13, 2016: Journal of Antimicrobial Chemotherapy
Eduardo E Arteaga-Bracho, Maria Gulinello, Michael L Winchester, Nandini Pichamoorthy, Jenna R Petronglo, Alicia D Zambrano, Julio Inocencio, Chirstopher D De Jesus, Joseph O Louie, Solen Gokhan, Mark F Mehler, Aldrin E Molero
The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing forebrain of Huntington's disease (HD) mouse models. Whether these developmental alterations are due to loss- or gain-of-function mechanisms and contribute to HD pathogenesis is unknown. We examined the role of selective loss of huntingtin (Htt) function during development on postnatal vulnerability to cell death. We employed mice expressing very low levels of Htt throughout embryonic life to postnatal day 21 (Hdh(d•hyp))...
September 10, 2016: Neurobiology of Disease
Xiaoyan Cui, Shane M Nichols, Oriol Arteaga, John Freudenthal, Froilanny Paula, Alexander G Shtukenberg, Bart Kahr
Accounting for the interactions of light with heterogeneous, anisotropic, absorbing, optically active media is part of the characterization of complex, transparent materials. Stained biological structures in thin tissue sections share many of these features, but systematic optical analyses beyond the employ of the simple petrographic microscopes have not be established. Here, this accounting is made for polycrystalline, spherulitic bundles of twisted d-mannitol lamellae grown from melts containing light-absorbing molecules...
September 21, 2016: Journal of the American Chemical Society
Farah Adel, José Manuel Ramia, Luis Gijón, Roberto de la Plaza-Llamas, Vladimir Arteaga-Peralta, Carmen Ramiro-Perez
BACKGROUND: Cystic echinococcosis is a zoonosis caused by larvae of the parasite Echinococcus that is endemic in many countries of the Mediterranean area. It can affect any organ, with the most common sites being liver (70%) and lung (20%). Splenic hydatid disease, despite being rare, is the third most common location. Other locations such as bone, skin, or kidney are exceptional. OBJECTIVE: To present our experience in extrahepatic and extrapulmonary hydatidosis...
September 5, 2016: Cirugia y Cirujanos
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