keyword
https://read.qxmd.com/read/38095151/clinical-and-radiological-correlates-of-apathy-in-multiple-sclerosis
#21
JOURNAL ARTICLE
Francesco Tazza, Simona Schiavi, Elisa Leveraro, Maria Cellerino, Giacomo Boffa, Stefania Ballerini, Mara Dighero, Antonio Uccelli, Elvira Sbragia, Kenda Aluan, Matilde Inglese, Caterina Lapucci
BACKGROUND: Although apathy has been associated with fronto-striatal dysfunction in several neurological disorders, its clinical and magnetic resonance imaging (MRI) correlates have been poorly investigated in people with multiple sclerosis (PwMS). OBJECTIVES: To evaluate clinical variables and investigate microstructural integrity of fronto-striatal grey matter (GM) and white matter (WM) structures using diffusion tensor imaging (DTI). METHODS: A total of 123 PwMS (age: 40...
December 14, 2023: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38015288/prevalence-treatment-and-neural-correlates-of-apathy-in-different-forms-of-dementia-a-narrative-review
#22
REVIEW
Ilaria Parrotta, Stefano Cacciatore, Flavio D'Andrea, Marianna D'Anna, Giulia Giancaterino, Giovanni Lazzaro, Giorgio Arcara, Nicoletta Manzo
OBJECTIVES: The aim of this review is to provide an overview on prevalence and clinical tools for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings obtained from studies in patients with apathy in different forms of dementia, including Alzheimer's disease (AD), vascular (VaD) and mixed dementia, frontotemporal dementia (FTD), and Parkinson's disease dementia (PDD). METHODS: Randomized controlled trials, non-randomized controlled trials, controlled before-after studies, and interrupted time series from four databases (WebOfScience, Scopus, Pubmed, and PsycINFO) addressing apathy in adults or older people aged over 65 years of age affected by dementia were included...
November 28, 2023: Neurological Sciences
https://read.qxmd.com/read/38012101/comparative-efficacy-of-multiple-non-pharmacological-interventions-for-behavioural-and-psychological-symptoms-of-dementia-a-network-meta-analysis-of-randomised-controlled-trials
#23
REVIEW
Zihan Yin, Yaqin Li, Qiongnan Bao, Xinyue Zhang, Manze Xia, Wanqi Zhong, Kexin Wu, Jin Yao, Zhenghong Chen, Mingsheng Sun, Ling Zhao, Fanrong Liang
Non-pharmacological interventions can improve the behavioural and psychological symptoms of dementia (BPSD). However, the optimal non-pharmacological treatments remain controversial. This study aimed to compare the efficacy of multiple non-pharmacological methods and identify the optimal therapy for BPSD. Potential randomised controlled trials (RCTs) were searched and selected from 15 databases and sources from the inception of the databases until 1 October 2022. Two independent authors implemented study screening, data extraction, and methodological quality assessment...
November 27, 2023: International Journal of Mental Health Nursing
https://read.qxmd.com/read/37995462/prevalence-of-post-stroke-cognitive-impairment-and-associated-risk-factors-in-chinese-stroke-survivors
#24
JOURNAL ARTICLE
Janita Pak Chun Chau, Suzanne Hoi Shan Lo, Jie Zhao, Kai Chow Choi, Laveeza Butt, Alexander Yuk Lun Lau, Vincent Chung Tong Mok, Zoe Ching Man Kwok, David R Thompson
BACKGROUND: Post-stroke cognitive impairment (PSCI) adversely affects survivors' recovery trajectory and overall health outcomes. This study aimed to investigate the prevalence of PCSI and its associated risk factors. METHODS: A cross-sectional study was conducted with stroke survivors recruited from the neurology units of three hospitals in Yunnan, China. Measures included the Frenchay Aphasia Screening Test (FAST), Apathy Evaluation Scale (AES), Fatigue Severity Scale (FSS), Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE), Montreal Cognitive Assessment (MoCA), and Charlson Comorbidity Index (CCI)...
December 15, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37983366/predictive-factors-of-apathy-in-stroke-survivors-during-the-recovery-period
#25
JOURNAL ARTICLE
Pao-Chen Wang, Hsiang-Chu Pai
BACKGROUND: Apathy may be an important predictor of depression and significantly negatively affect the quality of life and functional recovery of stroke survivors. However, the evidence reflects the inconsistent findings of studies on the impact of individual-related variables on apathy in patients with stroke. OBJECTIVES: This study examines the relationships among stroke survivors' individual characteristics, background variables, disease-related variables, and apathy; furthermore, we identify predictors of apathy...
November 20, 2023: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://read.qxmd.com/read/37970813/measurement-of-neuropsychiatric-symptoms-in-the-older-adults-with-mild-cognitive-impairment-based-on-speech-and-facial-expressions-a-cross-sectional-observational-study
#26
JOURNAL ARTICLE
Ying Zhou, Xiuyu Yao, Wei Han, Yingxin Li, Jiajun Xue, Zheng Li
OBJECTIVES: To examine the association between speech and facial features with depression, anxiety, and apathy in older adults with mild cognitive impairment (MCI). METHODS: Speech and facial expressions of 319 MCI patients were digitally recorded via audio and video recording software. Three of the most common neuropsychiatric symptoms (NPS) were evaluated by the Public Health Questionnaire, General Anxiety Disorder, and Apathy Evaluation Scale, respectively...
November 16, 2023: Aging & Mental Health
https://read.qxmd.com/read/37968562/impulsive-compulsive-behaviour-in-early-parkinson-s-disease-is-determined-by-apathy-and-dopamine-receptor-d3-polymorphism
#27
JOURNAL ARTICLE
Hendrik Theis, Stéphane Prange, Gérard N Bischof, Merle C Hoenig, Marc Tittgemeyer, Lars Timmermann, Gereon R Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimeren
Impulsive-compulsive behaviour (ICB) is a frequently observed non-motor symptom in early Parkinson's disease after initiating dopamine replacement therapy. At the opposite end of the motivated behaviour spectrum, apathy occurs in early Parkinson's disease even before dopamine replacement is started. The co-occurrence of these behavioural conditions in Parkinson's disease raises questions about their relationship and underlying pathophysiological determinants. In previous imaging or genetic studies, both conditions have been associated with the limbic dopaminergic system...
November 15, 2023: NPJ Parkinson's Disease
https://read.qxmd.com/read/37914222/connectivity-patterns-of-the-core-resting-state-networks-associated-with-apathy-in-late-life-depression
#28
JOURNAL ARTICLE
Jean-Charles Roy, Thomas Desmidt, Sébastien Dam, Iris Mirea-Grivel, Louise Weyl, Elise Bannier, Laurent Barantin, Dominique Drapier, Jean-Marie Batail, Renaud David, Julie Coloigner, Gabriel H Robert
BACKGROUND: Apathy is associated with reduced antidepressant response and dementia in late-life depression (LLD). However, the functional cerebral basis of apathy is understudied in LLD. We investigated the functional connectivity of 5 resting-state networks (RSN) hypothesized to underlie apathy in LLD. METHODS: Resting-state functional MRI data were collected from individuals with LLD who did not have dementia as well as healthy older adults between October 2019 and April 2022...
2023: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/37787503/noradrenergic-alterations-in-parkinson-s-disease-a-combined-11c-yohimbine-pet-neuromelanin-mri-study
#29
JOURNAL ARTICLE
Chloé Laurencin, Sophie Lancelot, Sarah Brosse, Inés Mérida, Jérôme Redouté, Elise Greusard, Ludovic Lamberet, Véronique Liotier, Didier Le Bars, Nicolas Costes, Stéphane Thobois, Philippe Boulinguez, Bénédicte Ballanger
Degeneration of the noradrenergic system is now considered a pathological hallmark of Parkinson's disease but little is known about its consequences in terms of parkinsonian manifestations. Here, we evaluate two aspects of the noradrenergic system using multimodal in vivo imaging in patients with Parkinson's disease and healthy controls: the pigmented cell bodies of the locus coeruleus with neuromelanin sensitive MRI and the density of α2-adrenergic receptors (ARs) with PET using [11C]yohimbine. Thirty patients with Parkinson's disease and thirty age- and sex-matched healthy control subjects were included...
October 3, 2023: Brain
https://read.qxmd.com/read/37787488/motivational-and-cognitive-predictors-of-apathy-after-subthalamic-nucleus-stimulation-in-parkinson-s-disease
#30
JOURNAL ARTICLE
Matthieu Béreau, Astrid Kibleur, Mathieu Servant, Gautier Clément, Kathy Dujardin, Anne-Sophie Rolland, Thomas Wirth, Ouhaid Lagha-Boukbiza, Jimmy Voirin, Marie des Neiges Santin, Elodie Hainque, David Grabli, Alexandre Comte, Sophie Drapier, Franck Durif, Ana Marques, Alexandre Eusebio, Jean-Philippe Azulay, Caroline Giordana, Jean-Luc Houeto, Béchir Jarraya, David Maltete, Olivier Rascol, Tiphaine Rouaud, Mélissa Tir, Caroline Moreau, Teodor Danaila, Stéphane Prange, Laurent Tatu, Christine Tranchant, Jean-Christophe Corvol, David Devos, Stephane Thobois, Maxime Desmarets, Mathieu Anheim
Postoperative apathy is a frequent symptom in Parkinson's disease patients who have undergone bilateral deep brain stimulation of the subthalamic nucleus. Two main hypotheses for postoperative apathy have been suggested: i) dopaminergic withdrawal syndrome relative to postoperative dopaminergic drug tapering and ii) direct effect of chronic stimulation of the subthalamic nucleus. The primary objective of our study was to describe preoperative and one-year postoperative apathy in Parkinson's disease patients who underwent chronic bilateral deep brain stimulation of the subthalamic nucleus...
October 3, 2023: Brain
https://read.qxmd.com/read/37772149/empathic-accuracy-task-indian-adaptation-and-validation
#31
JOURNAL ARTICLE
Preeti Sinha, Urvakhsh M Mehta, Anuradha S N, Prerna Srivastava
BACKGROUND: The Empathic Accuracy Task (EAT) is an objective measure to assess empathic accuracy. Due to the variability in the number and linked emotions of the narrated events, we adapted EAT for the Indian sociocultural setting as Indian EAT (I-EAT). METHODS: Eight videos were adapted in three languages (English, Hindi, and Kannada), narrating emotional events with a uniform representation of age groups, different emotions, and sex. The adapted I-EAT was then validated by cross-sectional comparison with different tests similar to EAT and those that assessed concepts different from or similar to empathy, in 29 healthy young adults, 23 healthy older adults (aged ≥60 years) along with clinical groups of 15 young people with depression, 15 older people with depression, and 15 young people with schizophrenia...
September 2023: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/37740198/psychiatric-burden-in-a-cohort-of-adults-with-niemann-pick-type-c-disease-from-psychotic-symptoms-to-frontal-lobe-behavioral-disorders
#32
JOURNAL ARTICLE
A Morin, G Carle, A Ponchel, G Fernández-Eulate, Y Nadjar
OBJECTIVES: To describe Niemann-Pick type C (NP-C) behavioral symptoms (focusing on psychotic symptoms) and its relation to frontal lobe functioning. METHODS: We retrospectively reviewed medical charts of NP-C-patients followed in the Lysosomal Diseases reference center in Paris Pitié-Salpêtrière. We collected demographic data, psychiatric clinical manifestations, psychometric scales, and extended neuropsychological data including executive and behavioral frontal lobe functions evaluations...
September 22, 2023: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/37695629/racial-differences-in-clinical-presentation-in-individuals-diagnosed-with-frontotemporal-dementia
#33
JOURNAL ARTICLE
Hannah A Jin, Corey T McMillan, Isabel Yannatos, Lauren Fisher, Emma Rhodes, Sarah F Jacoby, David J Irwin, Lauren Massimo
IMPORTANCE: Prior research suggests there are racial disparities in the presentation of dementia, but this has not been investigated in the context of frontotemporal dementia (FTD). OBJECTIVE: To explore racial disparities in dementia severity, functional impairment, and neuropsychiatric symptoms in individuals with a diagnosis of FTD. DESIGN, SETTING, AND PARTICIPANTS: This exploratory cross-sectional study of National Alzheimer's Coordinating Center (NACC) data collected between June 2005 to August 2021 evaluated Asian, Black, and White individuals with a diagnosis of FTD (behavioral variant FTD or primary progressive aphasia)...
September 11, 2023: JAMA Neurology
https://read.qxmd.com/read/37680943/findmyapps-compared-with-usual-tablet-use-to-promote-social-health-of-community-dwelling-people-with-mild-dementia-and-their-informal-caregivers-a-randomised-controlled-trial
#34
JOURNAL ARTICLE
David P Neal, Teake P Ettema, Marissa D Zwan, Karin Dijkstra, Evelyn Finnema, Maud Graff, Majon Muller, Rose-Marie Dröes
BACKGROUND: FindMyApps is a tablet-based eHealth intervention designed to help people learn to use a tablet and find easy-to-use apps. This study evaluated the effectiveness of FindMyApps for supporting social health of people living with dementia, and sense of competence of their informal caregivers. METHODS: A single-centre, two-arm, non-blinded randomised controlled trial was conducted (Netherlands Trial Register NL8157). From 1st January 2020 to 31st July 2022, community-dwelling people in the Netherlands with a pre-established diagnosis of mild cognitive impairment (MCI) or dementia (Brief Cognitive Rating Scale 17-32), an informal caregiver and internet connection were allocated by block randomisation to receive FindMyApps or digital care-as-usual...
September 2023: EClinicalMedicine
https://read.qxmd.com/read/37662035/fluctuations-in-parkinson-s-disease-and-personalized-medicine-bridging-the-gap-with-the-neuropsychiatric-fluctuation-scale
#35
JOURNAL ARTICLE
Emmanuelle Schmitt, Bettina Debu, Ana Castrioto, Andrea Kistner, Valerie Fraix, Martine Bouvard, Elena Moro
BACKGROUND: Neuropsychiatric fluctuations (NpsyF) are frequent and disabling in people with Parkinson's disease (PD). In OFF-medication, NpsyF entail minus neuropsychiatric symptoms (NPS) like anxiety, apathy, sadness, and fatigue. In ON-medication, NpsyF consist in plus NPS, such as high mood, hypomania, and hyperactivity. Accurate identification of these NpsyF is essential to optimize the overall PD management. Due to lack of punctual scales, the neuropsychiatric fluctuation scale (NFS) has been recently designed to assess NpsyF in real time...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37655494/neuropsychiatric-features-in-a-multi-ethnic-population-with-alzheimer-disease-and-mild-cognitive-impairment
#36
JOURNAL ARTICLE
Katrina Celis, Andrew Zaman, Larry Deon Adams, Olivia Gardner, Rajabli Farid, Takiyah D Starks, Faina C Lacroix, Kara Hamilton-Nelson, Pedro Mena, Sergio Tejada, Renee Laux, Yeunjoo E Song, Allison Caban-Holt, Briseida Feliciano-Astacio, Jeffery M Vance, Jonathan L Haines, Goldie S Byrd, Gary W Beecham, Margaret A Pericak-Vance, Michael L Cuccaro
BACKGROUND: Alzheimer disease (AD) is more prevalent in African American (AA) and Hispanic White (HIW) compared to Non-Hispanic White (NHW) individuals. Similarly, neuropsychiatric symptoms (NPS) vary by population in AD. This is likely the result of both sociocultural and genetic ancestral differences. However, the impact of these NPS on AD in different groups is not well understood. METHODS: Self-declared AA, HIW, and NHW individuals were ascertained as part of ongoing AD genetics studies...
September 2023: International Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37651842/the-prevalence-of-apathy-in-stroke-patients-a-systematic-review-and-meta-analysis
#37
REVIEW
Hanrui Zhang, Yaoting Feng, Hequn Lv, Shaowen Tang, Yongjun Peng
BACKGROUND: Apathy is a frequent neuropsychiatric disorder in stroke patients. However, its prevalence rates have conflicting results across studies. This meta-analysis aimed to estimate the overall prevalence of apathy in stroke patients from 1990 to 2022. METHODS: PubMed, Web of Science, Embase and PsycINFO were systematically searched to identify relevant articles published from January 1, 1990 to October 29, 2022. Literature quality was assessed with the National Institutes of Health Study Quality Assessment Tool...
October 2023: Journal of Psychosomatic Research
https://read.qxmd.com/read/37629464/mild-behavioral-impairment-in-psychogeriatric-patients-clinical-features-and-psychopathology-severity
#38
JOURNAL ARTICLE
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Famà, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
The Mild Behavioral Impairment (MBI) concept was developed to determine whether late-onset persistent neuropsychiatric symptoms (NPSs) may be early manifestations of cognitive decline. Our study aims to investigate the prevalence and differentiating features of MBI with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). A total of 144 elderly patients who were referred to our psychogeriatric outpatient service were recruited. The severity of mental illness was evaluated by means of the Clinical Global Impression Severity scale, the severity of psychopathology was evaluated by means of the Brief Psychiatric Rating Scale (BPRS), and overall functioning was evaluated by means of the Global Assessment of Functioning scale...
August 21, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37572079/the-structure-of-apathy-symptoms
#39
JOURNAL ARTICLE
Matthew Calamia, Kristian Markon, Daniel Tranel
INTRODUCTION: Apathy is common in many neurological, psychiatric, and medical disorders and is related to a number of important clinical outcomes. Nonetheless, research on apathy is hindered by different ways of defining and measuring it, which has led to heterogeneity in research findings. METHOD: The current study aimed to investigate the factor structure of apathy symptoms using a novel item pool. We examined whether the use of this item pool has incremental validity above and beyond a widely used measure in predicting cognition and everyday functioning...
August 12, 2023: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/37532622/safety-tolerability-and-preliminary-efficacy-of-syn120-a-dual-5-ht6-5-ht2a-antagonist-for-the-treatment-of-parkinson-disease-dementia-a-randomized-controlled-proof-of-concept-trial
#40
RANDOMIZED CONTROLLED TRIAL
Hubert H Fernandez, Daniel Weintraub, Eric Macklin, Irene Litvan, Michael A Schwarzschild, Jamie Eberling, Aleksandar Videnovic, Christopher J Kenney
BACKGROUND: SYN120 is a dual serotonin receptor (5-HT6/5-HT2A) antagonist hypothesized to improve cognition and psychiatric symptoms. OBJECTIVES: We evaluated the safety, tolerability, and efficacy of SYN120 in patients with Parkinson disease dementia (PDD). METHODS: In a multicenter, double-blind, parallel-group, 16-week phase 2a proof-of-concept trial in PDD with concomitant cholinesterase inhibitor use, eligible patients were randomized to oral SYN120 (100 mg/day) or placebo...
September 2023: Parkinsonism & related Disorders
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