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https://www.readbyqxmd.com/read/28818699/apathy-in-people-with-epilepsy-and-its-clinical-significance-a-case-control-study
#1
Jong-Geun Seo, Gun-Hee Lee, Sung-Pa Park
PURPOSE: Apathy as a state of decreased motivation has not been highlighted in people with epilepsy (PWE). We investigated its clinical significance in PWE. METHODS: We invited adult PWE who had been administered antiepileptic drugs (AEDs) for at least 1year and compared them with age- and gender-matched healthy controls. Eligible participants completed several questionnaires including the Apathy Evaluation Scale-Self (AES-S), the Korean version of the Neurological Disorders Depression Inventory for Epilepsy (K-NDDI-E), the Generalized Anxiety Disorder-7 (GAD-7), the Epworth Sleepiness Scale (ESS), and the Insomnia Severity Index (ISI), and the Quality of Life in Epilepsy-10 (QOLIE-10)...
August 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28803229/non-motor-symptoms-assessed-by-non-motor-symptoms-questionnaire-and-non-motor-symptoms-scale-in-parkinson-s-disease-in-selected-asian-populations
#2
Anna Sauerbier, Onanong Jitkritsadakul, Nataliya Titova, Lisa Klingelhoefer, Yoshio Tsuboi, Harry Carr, Hrishikesh Kumar, Rebecca Banerjee, Roberto Erro, Roongroj Bhidayasiri, Anette Schrag, Panagiotis Zis, Shen-Yang Lim, J Y Al-Hashel, Walaa A Kamel, Pablo Martinez-Martin, K Ray Chaudhuri
BACKGROUND: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. SUMMARY: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS)...
August 12, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28802937/apathy-in-parkinson-s-disease
#3
Javier Pagonabarraga, Jaime Kulisevsky
The normal maintenance of human motivation depends on the integrity of subcortical structures that link the medial and lateral prefrontal cortex with the limbic system. Apathy is highly prevalent in Parkinson's disease and causes major impact on the quality of life of patients and caregivers, comparable to depression or cognitive impairment. The clinical differentiation of apathy from the emotional symptoms of depression, and from difficulties in planning or organizing mental programs as a consequence of executive dysfunction, may guide a rationale for individualized treatment approach of apathetic symptoms, which is presently lacking...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28797564/impact-of-anxiety-apathy-and-reduced-functional-autonomy-on-perceived-quality-of-life-in-parkinson-s-disease
#4
Alfonsina D'Iorio, Carmine Vitale, Fausta Piscopo, Chiara Baiano, Anna Paola Falanga, Katia Longo, Marianna Amboni, Paolo Barone, Gabriella Santangelo
INTRODUCTION: Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment...
August 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28791690/apathy-risk-factor-for-mortality-in-nursing-home-patients
#5
Johanna M H Nijsten, Ruslan Leontjevas, Ron Pat-El, Martin Smalbrugge, Raymond T C M Koopmans, Debby L Gerritsen
OBJECTIVES: To determine the prognostic value of apathy for mortality in patients of somatic (SC) and dementia special care (DSC) nursing home (NH) units. DESIGN: Longitudinal design, secondary analyses of a 2-year, cluster-randomized trial with six measurements, approximately 4 months in between. SETTING: SC and DSC-units of Dutch NHs. PARTICIPANTS: NH-patients of seventeen SC-units (n = 342) and sixteen DCS-units (n = 371)...
August 9, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28764696/healthcare-quality-improvement-and-work-engagement-concluding-results-from-a-national-longitudinal-cross-sectional-study-of-the-productive-ward-releasing-time-to-care-programme
#6
Mark White, Tony Butterworth, John Sg Wells
BACKGROUND: Concerns about patient safety and reducing harm have led to a particular focus on initiatives that improve healthcare quality. However Quality Improvement (QI) initiatives have in the past typically faltered because they fail to fully engage healthcare professionals, resulting in apathy and resistance amongst this group of key stakeholders. Productive Ward: Releasing Time to Care (PW) is a ward-based QI programme created to help ward-based teams redesign and streamline the way that they work; leaving more time to care for patients...
August 1, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28759970/a-novel-assessment-and-profiling-of-multidimensional-apathy-in-alzheimer-s-disease
#7
Ratko Radakovic, John M Starr, Sharon Abrahams
BACKGROUND: Apathy is a complex multidimensional syndrome frequently reported in Alzheimer's disease (AD) and is associated with impaired awareness. Here we present a psychometrically robust method to profile apathy in AD. OBJECTIVES: To determine the validity and reliability of a multidimensional apathy measure, the Dimensional Apathy Scale (DAS), and explore the apathy subtype profile and its associations in AD. METHODS: 102 people with AD and 55 healthy controls were recruited...
July 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28759804/multidimensional-apathy-and-executive-dysfunction-in-amyotrophic-lateral-sclerosis
#8
Ratko Radakovic, Laura Stephenson, Judith Newton, Christopher Crockford, Robert Swingler, Siddharthan Chandran, Sharon Abrahams
Apathy and cognitive dysfunction are prominent symptoms of Amyotrophic lateral sclerosis (ALS). More specifically ALS patients show increased Initiation apathy-a lack of motivation for self-generation of thoughts as assessed by the Dimensional Apathy Scale. This study aimed to investigate the cognitive underpinnings of apathy subtypes in ALS. We hypothesized that increased Initiation apathy would be associated deficits on tests of intrinsic response generation, such as verbal fluency. We also explored the relationship of other apathy subtypes to cognitive processes, in particular emotional apathy with emotional and social cognition deficits and executive apathy with planning and goal management deficits...
July 13, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28734148/apathy-in-early-and-late-life-depression
#9
Isis Groeneweg-Koolhoven, Merel Ploeg, Hannie C Comijs, Brenda Wjh Penninx, Roos C van der Mast, Robert A Schoevers, Didi Rhebergen, Eric van Exel
BACKGROUND: Late-life depression is thought to differ in clinical presentation from early-life depression. Particularly, late-life depression is considered to be more characterized by apathy than is early-life depression. Lacking convincing evidence, this study examines the presence and associated socio-demographic/clinical characteristics of apathy in older compared to younger depressed persons. METHODS: This cross-sectional study used data from two naturalistic cohort studies, i...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28711816/unilateral-subthalamotomy-in-parkinson-s-disease-cognitive-psychiatric-and-neuroimaging-changes
#10
Ignacio Obeso, Enrique Casabona, Rafael Rodríguez-Rojas, Maria Luisa Bringas, Raúl Macías, Nancy Pavón, Jose A Obeso, Marjan Jahanshahi
Unilateral subthalamotomy is an effective treatment for the cardinal motor features of Parkinson's disease (PD). However, non-motor changes possibly associated with right or left subthalamotomy remain unknown. Our aim was to assess cognitive, psychiatric and neuroimaging changes after treatment with unilateral subthalamotomy. Fourteen medicated patients with PD were evaluated before and after (mean 6 months after operation) unilateral subthalamotomy (5 right, 9 left). In addition to motor assessments, cognitive (global cognition and executive functions), psychiatric (apathy, depression, anxiety, mania, hypo- and hyperdopaminergic behaviours, impulsivity), quality of life evaluations and volume of lesions were obtained...
June 27, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28680314/physical-activity-level-of-ambulatory-stroke-patients-is-it-related-to-neuropsychological-factors
#11
Burcu Ersöz Hüseyinsinoğlu, Gökşen Kuran Aslan, Devrim Tarakci, Arzu Razak Özdinçler, Hayriye Küçükoğlu, Sevim Baybaş
INTRODUCTION: Physical inactivity is an important risk factor for stroke and stroke recurrence. There is insufficient knowledge about the physical activity (PA) level in stroke patients who are ambulatory in the subacute phase. Our aim was to compare the PA level between ambulatory stroke patients and a population of the same age and to investigate neuropsychological factors that could affect the PA level in the same stroke group. METHODS: Eighty-five subacute stroke patients and 58 healthy subjects were included...
June 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28676310/an-investigation-into-the-effects-and-prognostic-factors-of-cognitive-decline-following-subthalamic-nucleus-stimulation-in-patients-with-parkinson-s-disease
#12
Taro Nimura, Ken-Ichi Nagamatsu, Tadashi Ando, Arifumi Matsumoto, Kinya Hisanaga, Teiji Tominaga
We retrospectively investigated the effects of subthalamic nucleus stimulation (STN-DBS) on new postoperative onset of cognitive decline and prognostic factors for advanced Parkinson's disease (PD). We studied 39 PD patients who had received bilateral STN-DBS. Clinical symptoms, cognitive function, psychiatric function, and health-related quality of life (HRQOL) were assessed before and six months after surgery. Based on the results of neuropsychological examinations six months after the surgery, the subjects were divided into those with and those without cognitive decline...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28645961/cognitive-screening-and-behavioural-observation-of-functional-ability-in-patients-with-multiple-episode-schizophrenia-an-exploratory-study
#13
Eva Norlin Bagge, Eva Esbjörnsson, Katharina S Sunnerhagen
OBJECTIVES: To evaluate the usability of a neuropsychological screening instrument and two observation scales of everyday behaviour to describe cognitive and functional capacity of patients with multiepisode schizophrenia and considerable care needs, who frequently refuse to participate in cognitive testing or performance-based functional measurement. SETTING: One psychiatric unit specialised in severe mental illness at the Sahlgrenska University Hospital, Gothenburg, Sweden...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28643887/personality-dopamine-and-parkinson-s-disease-insights-from-subthalamic-stimulation
#14
Eugénie Lhommée, François Boyer, Maxime Wack, Pierre Pélissier, Hélène Klinger, Emmanuelle Schmitt, Amélie Bichon, Valérie Fraix, Stéphan Chabardès, Patrick Mertens, Anna Castrioto, Andrea Kistner, Emmanuel Broussolle, Stéphane Thobois, Paul Krack
BACKGROUND: Subthalamic stimulation improves the motor and neuropsychiatric symptoms of Parkinson's disease. However, the impact of this treatment on impulse control and personality is the subject of heavy debate. The objective of this study was to investigate personality changes after subthalamic stimulation. METHODS: Using Cloninger's biosocial model, we assessed personality in 73 Parkinson's disease patients before and 12 months after subthalamic stimulation accompanied by a drastic reduction in dopaminergic medication...
June 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28632431/psychometric-testing-of-a-swedish-version-of-the-apathy-evaluation-scale
#15
Maurits Johansson, Per Johansson, Erik Stomrud, Peter Hagell, Oskar Hansson
BACKGROUND: Apathy, a prevalent and clinically relevant symptom in neurodegenerative disease, is often evaluated by the instrument Apathy Evaluation Scale (AES). However, this instrument has not been translated into Swedish, halting clinical and research efforts. Furthermore, previous studies lack analyses of some basic properties, such as the legitimacy of a total score, or have analysed dimensionality by questionable methods. AIM: To translate and psychometrically evaluate a Swedish version of the AES...
June 20, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28606500/is-there-a-specific-psychiatric-background-or-personality-profile-in-functional-dystonia
#16
Aleksandra Tomić, Igor Petrović, Danilo Pešić, Marija Mitković Vončina, Marina Svetel, Nataša Dragašević Mišković, Aleksandra Potrebić, Dušica Lečić Toševski, Vladimir S Kostić
OBJECTIVE: The aim of this cross-sectional study was to identify if there was a specific difference between patients with functional dystonia (DysF) and those with adult-onset, isolated idiopathic ("primary") dystonia (DysP) in terms of psychiatric disorders, psychological stressor, dissociation correlates, and personality traits. METHODS: Thirty-nine clinically definite DysF and 30 DysP patients matched by age, gender and dystonia distribution underwent psychiatric interview based on DSM-5 criteria and additional testings for global cognitive and psychiatric functions (Mini-Mental State Examination, Hamilton Depression and Hamilton Anxiety Rating Scale, Apathy Scale, Somatoform Dissociation Questionnaire-20, Dissociative Experiences Scale II, and the five-dimensional Revised Neuroticism-Extroversion-Openness Personality Inventory)...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28585294/ichthyosis-fetalis-in-a-cross-bred-lamb
#17
Antonio Carlos Lopes Câmara, Pedro Augusto Cordeiro Borges, Silvano Alves Paiva, Felipe Pierezan, Benito Soto-Blanco
BACKGROUND: Ichthyosis is a dermatological disease characterized by varying degrees of generalized hyperkeratosis and alopecia. Two congenital forms of ichthyosis are recognized in animals: fetalis (IF) and congenita. The disease occurs rarely in cattle, swine, dogs, chickens and a goat; it has not been reported in sheep. HYPOTHESIS/OBJECTIVES: To provide clinical, laboratory and pathological assessments of a case of IF in a cross-bred lamb. ANIMALS: A male cross-bred lamb...
June 5, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28579759/a-randomized-trial-of-individual-versus-group-format-exercise-and-self-management-in-individuals-with-parkinson-s-disease-and-comorbid-depression
#18
Martha Sajatovic, Angela L Ridgel, Ellen M Walter, Curtis M Tatsuoka, Kari Colón-Zimmermann, Riane K Ramsey, Elisabeth Welter, Steven A Gunzler, Christina M Whitney, Benjamin L Walter
BACKGROUND: Depression is common in people with Parkinson's disease (PD), and exercise is known to improve depression and PD. However, lack of motivation and low self-efficacy can make exercise difficult for people with PD and comorbid depression (PD-Dep). A combined group exercise and chronic disease self-management (CDSM) program may improve the likeli-hood that individuals will engage in exercise and will show a reduction in depression symptoms. The purpose of this study was to compare changes in depression in PD-Dep between individual versus group exercise plus CDSM and to examine participant adherence and perception of the interventions...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28579482/precuneus-degeneration-and-isolated-apathy-in-patients-with-parkinson-s-disease
#19
Jung Hwan Shin, Seong A Shin, Jee-Young Lee, Hyunwoo Nam, Jae-Sung Lim, Yu Kyeong Kim
INTRODUCTION: To investigate isolated apathy in a set of consecutively enrolled Parkinson's disease (PD) patients without dementia, depression, and significant motor response fluctuations, by conducting neuropsychological and neuroimaging analyses. METHODS: One hundred twenty-four patients were eligible for inclusion in this study. Clinical information and data were collected from a predefined neuropsychological test battery, including the mini-mental status examination, apathy scale, geriatric depression scale, digit span test, Boston naming test, Seoul verbal learning test, controlled oral word association test, go-no-go test, and the Rey figure copy test...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28578330/the-efficacy-of-high-frequency-repetitive-transcranial-magnetic-stimulation-for-improving-apathy-in-chronic-stroke-patients
#20
Nobuyuki Sasaki, Takatoshi Hara, Naoki Yamada, Masachika Niimi, Wataru Kakuda, Masahiro Abo
Although repetitive transcranial magnetic stimulation (rTMS) for hemiparesis is beneficial, so far no study has examined the usefulness of rTMS for apathy. Thirteen patients with chronic stroke were assigned randomly to 2 groups: rTMS group (n = 7) and sham stimulation group (n = 6). The patients received 5 sessions of either high-frequency rTMS over the region spanning from the dorsal anterior cingulate cortex (dACC) to medial prefrontal cortex (mPFC) or sham stimulation for 5 days. The severity of apathy was evaluated using the Apathy Scale (AS) and the severity of depression was evaluated using the Quick Inventory of Depressive Symptomatology (QIDS) serially before and after the 5-day protocol...
2017: European Neurology
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