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https://www.readbyqxmd.com/read/29148293/quantity-of-movement-as-a-measure-of-engagement-for-dementia-the-influence-of-motivational-disorders
#1
Giulia Perugia, Daniel Rodríguez-Martín, Marta Díaz Boladeras, Andreu Català Mallofré, Emilia Barakova, Matthias Rauterberg
Engagement in activities is crucial to improve quality of life in dementia. Yet, its measurement relies exclusively on behavior observation and the influence that behavioral and psychological symptoms of dementia (BPSD) have on it is overlooked. This study investigated whether quantity of movement, gauged with a wrist-worn accelerometer, could be a sound measure of engagement and whether apathy and depression negatively affected engagement. Fourteen participants with dementia took part in 6 sessions of activities: 3 of cognitive games (eg, jigsaw puzzles) and 3 of robot play (Pleo)...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29143702/association-between-altered-neurochemical-metabolites-and-apathy-in-patients-with-alzheimer-s-disease
#2
Yi-Chun Yeh, Chun-Wei Li, Yu-Ting Kuo, Mei-Feng Huang, Tai-Ling Liu, Twei-Shiun Jaw, Yi-Hsin Yang, Kuang-Che Kuo, Cheng-Sheng Chen
BACKGROUND: Apathy is a condition characterized by a lack of motivation that manifests in emotional, behavioral, and cognitive domains. Although previous studies have indicated that apathy is associated with frontal lesions, few studies have focused on the different subdomains of apathy, and no in vivo human biochemical data have been obtained to examine the neurochemical changes related to apathy in patients with Alzheimer's disease (AD). Thus, we investigated the frontal neurochemical alterations related to apathy among patients with AD using proton magnetic resonance spectroscopy (1H MRS)...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29131091/apathy-profile-in-parkinson-s-and-huntington-s-disease-a-comparative-cross-sectional-study
#3
Mário Sousa, Fradique Moreira, Joana Jesus-Ribeiro, Inês Marques, Flávia Cunha, Nádia Canário, António Freire, Cristina Januário
BACKGROUND/AIMS: Apathy is one of the most frequent, disabling and difficult-to-treat symptoms that show up in many neurodegenerative disorders. The aim of this study was to assess and compare apathy profile in Parkinson's and Huntington's patients using the same comprehensive instruments to measure apathy, cognition and depressive symptoms. MATERIALS AND METHODS: We consecutively assessed Parkinson's disease (PD) and Huntington's disease (HD) patients recruited from a Movement Disorders Unit...
November 13, 2017: European Neurology
https://www.readbyqxmd.com/read/29114969/apathy-in-rapid-eye-movement-sleep-behaviour-disorder-is-common-and-under-recognised
#4
Thomas R Barber, Kinan Muhammed, Daniel Drew, Michael Lawton, Marie Crabbe, Michal Rolinski, Timothy Quinnell, Zenobia Zaiwalla, Yoav Ben-Shlomo, Masud Husain, Michele Tm Hu
BACKGROUND: Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset of motor symptoms. Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing Parkinson's disease in future. Neuropsychiatric problems are common in RBD, but apathy has not previously been detailed in this key prodromal population. METHODS: 88 patients with polysomnographically proven RBD, 65 patients with PD and 33 controls were assessed for apathy using the Lille Apathy Rating Scale (LARS)...
November 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29079398/the-neural-correlates-of-apathy-in-schizophrenia-an-exploratory-investigation
#5
Fernando Caravaggio, Gagan Fervaha, Mahesh Menon, Gary Remington, Ariel Graff-Guerrero, Philip Gerretsen
BACKGROUND: Motivational deficits represent a core negative symptom in patients with schizophrenia. Previous morphology studies have demonstrated that apathy in patients with schizophrenia is associated with reduced frontal grey matter (GM). We attempted to replicate this previous finding, and explored whether it was distinct from potential associations with a distinct subdomain of negative symptoms, namely Affective Flattening, and GM. METHODS: Twenty medicated patients with schizophrenia provided structural T1-weighted images acquired on a 3-Tesla MRI scanner and negative symptoms were evaluated using the Scale for the Assessment of Negative Symptoms...
October 24, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29073590/temporal-associations-between-fatigue-depression-and-apathy-after-stroke-results-of-the-cognition-and-affect-after-stroke-a-prospective-evaluation-of-risks-study
#6
Elles Douven, Sebastian Köhler, Syenna H J Schievink, Robert J van Oostenbrugge, Julie Staals, Frans R J Verhey, Pauline Aalten
BACKGROUND: Poststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA. METHODS: A total of 250 stroke patients were included, of which 243 completed the Fatigue Severity Scale, Montgomery-Åsberg Depression Rating Scale, and Apathy Evaluation Scale at 3 months poststroke, with follow-up measurements at 6 and 12 months after initial testing...
October 26, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29069997/correction-to-m-johansson-et-al-psychometric-testing-of-a-swedish-version-of-the-apathy-evaluation-scale
#7
(no author information available yet)
No abstract text is available yet for this article.
October 25, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29066518/apathy-a-neurocircuitry-model-based-on-frontotemporal-dementia
#8
REVIEW
Simon Ducharme, Bruce H Price, Bradford C Dickerson
Apathy is a symptom shared among many neurological and psychiatric disorders. However, the underlying neurocircuitry remains incompletely understood. Apathy is one of the core features of behavioural variant frontotemporal dementia (bvFTD), a neurodegenerative disease presenting with heterogeneous combinations of socioaffective symptoms and executive dysfunction. We reviewed all neuroimaging studies of apathy in frontotemporal dementia (FTD) attempting to refine a neurocircuitry model and inform clinical definitions...
October 24, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#9
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037499/neuropsychiatric-and-cognitive-profile-of-early-richardson-s-syndrome-progressive-supranuclear-palsy-parkinsonism-and-parkinson-s-disease
#10
Clelia Pellicano, Francesca Assogna, Nystya Cellupica, Federica Piras, Mariangela Pierantozzi, Alessandro Stefani, Rocco Cerroni, Bruno Mercuri, Carlo Caltagirone, Francesco E Pontieri, Gianfranco Spalletta
INTRODUCTION: The two main variants of Progressive Supranuclear Palsy (PSP), Richardson's syndrome (PSP-RS) and PSP-parkinsonism (PSP-P), share motor and non-motor features with Parkinson's disease (PD) particularly in the early stages. This makes the precocious diagnosis more challenging. We aimed at defining qualitative and quantitative differences of neuropsychiatric and neuropsychological profiles between PSP-P, PSP-RS and PD patients recruited within 24 months after the onset of symptoms, in order to clarify if the identification of peculiar cognitive and psychiatric symptoms is of help for early PSP diagnosis...
October 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29032789/symptom-dimensions-of-depression-and-apathy-and-their-relationship-with-cognition-in-parkinson-s-disease
#11
Sarah M Szymkowicz, Vonetta M Dotson, Jacob D Jones, Michael S Okun, Dawn Bowers
OBJECTIVES: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. METHODS: A sample of 138 non-demented individuals with PD (mean age=64...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28991661/behavioral-and-affective-features-of-amyotrophic-lateral-sclerosis-patients
#12
Yasuyuki Ohta, Kota Sato, Mami Takemoto, Yoshiaki Takahashi, Ryuta Morihara, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Nozomi Hishikawa, Toru Yamashita, Koji Abe
Evaluating the cognitive and behavioral features in amyotrophic lateral sclerosis (ALS) patients is important for therapy and care. Fifty-seven ALS, 5 ALS with the behavioral variant of frontotemporal dementia (FTD) (ALS-FTD), 12 FTD patients, and 35 control subjects were evaluated by 10 different tests for cognitive and behavioral (mini-mental state examination (MMSE), Hasegawa dementia rating scale - revised (HDS-R), frontal assessment battery (FAB), Montreal cognitive assessment (MoCA), ALS-frontotemporal dementia-Questionnaire (ALS-FTD-Q), and anosognosia scale), affective (depression, apathy, and behavioral and psychological symptoms of dementia (BPSD)), and activities of daily living (ADL) assessments...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28990169/methylphenidate-cognition-and-epilepsy-a-1-month-open-label-trial
#13
Jesse Adams, Valerie Alipio-Jocson, Katherine Inoyama, Victoria Bartlett, Saira Sandhu, Jemima Oso, John J Barry, David W Loring, Kimford J Meador
OBJECTIVE: Cognitive difficulties are common in epilepsy. Beyond reducing seizures and adjusting antiepileptic medications, no well-validated treatment exists in adults. Methylphenidate is used effectively in children with epilepsy and attention-deficit/hyperactivity disorder, but its effects in adults have not been systematically evaluated. We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to a double-blind, placebo-controlled, single-dose study...
October 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28947882/the-problem-of-fatigue-in-patients-suffering-from-neoplastic-disease
#14
REVIEW
Agnieszka Kolak, Marzena Kamińska, Elwira Wysokińska, Dariusz Surdyka, Dariusz Kieszko, Magdalena Pakieła, Franciszek Burdan
Modern therapeutic management of patients with cancer is associated with many adverse side effects, including fatigue defined as weariness, burnout, lassitude, malaise, apathy, impatience, and/or inability to perform daily activities. It occurs frequently before the diagnosis of cancer and may persist for a long time after the end of cancer therapy. It is a common problem that occurs regardless of the type of cancer and applied therapeutic procedure. The appearance of this symptom significantly affects the quality of life of patients and often reduces the effectiveness of implemented treatment...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28945120/methylphenidate-for-apathy-in-community-dwelling-older-veterans-with-mild-alzheimer-s-disease-a-double-blind-randomized-placebo-controlled-trial
#15
Prasad R Padala, Kalpana P Padala, Shelly Y Lensing, Daniel Ramirez, Varun Monga, Melinda M Bopp, Paula K Roberson, Richard A Dennis, Frederick Petty, Dennis H Sullivan, William J Burke
OBJECTIVE: Apathy is a common behavioral problem in Alzheimer's disease. Apathy has profound consequences, such as functional impairment, higher service utilization, higher caregiver burden, and increased mortality. The authors' objective was to study the effects of methylphenidate on apathy in Alzheimer's disease. METHOD: A 12-week, prospective, double-blind, randomized, placebo-controlled trial (methylphenidate versus placebo) was conducted in community-dwelling veterans (N=60) with mild Alzheimer's disease...
September 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28926003/age-of-first-exposure-to-american-football-and-long-term-neuropsychiatric-and-cognitive-outcomes
#16
M L Alosco, A B Kasimis, J M Stamm, A S Chua, C M Baugh, D H Daneshvar, C A Robbins, M Mariani, J Hayden, S Conneely, R Au, A Torres, M D McClean, A C McKee, R C Cantu, J Mez, C J Nowinski, B M Martin, C E Chaisson, Y Tripodis, R A Stern
Previous research suggests that age of first exposure (AFE) to football before age 12 may have long-term clinical implications; however, this relationship has only been examined in small samples of former professional football players. We examined the association between AFE to football and behavior, mood and cognition in a large cohort of former amateur and professional football players. The sample included 214 former football players without other contact sport history. Participants completed the Brief Test of Adult Cognition by Telephone (BTACT), and self-reported measures of executive function and behavioral regulation (Behavior Rating Inventory of Executive Function-Adult Version Metacognition Index (MI), Behavioral Regulation Index (BRI)), depression (Center for Epidemiologic Studies Depression Scale (CES-D)) and apathy (Apathy Evaluation Scale (AES))...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28924104/validation-of-the-r2chads2-and-chads2-scores-for-predicting-post-stroke-cognitive-impairment
#17
Kazuo Washida, Hisatomo Kowa, Hirotoshi Hamaguchi, Fumio Kanda, Tatsushi Toda
Objective Post-stroke cognitive impairment often afflicts stroke survivors and is a major obstacle both for cognitive and physical rehabilitation. Stroke risk scores ["Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, Stroke" (CHADS2) and "CHADS2 + creatinine clearance <60 mL/min" (R2CHADS2)] are used to assess the future risk of cardioembolic stroke in patients with atrial fibrillation (AF). However, congestive heart failure, hypertension, aging, diabetes mellitus, stroke, and renal dysfunction are also risk factors for cognitive impairment...
October 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#18
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28912283/reaction-time-is-negatively-associated-with-corpus-callosum-area-in-the-early-stages-of-cadasil
#19
S Delorme, F De Guio, S Reyes, A Jabouley, H Chabriat, E Jouvent
BACKGROUND AND PURPOSE: Reaction time was recently recognized as a marker of subtle cognitive and behavioral alterations in the early clinical stages of CADASIL, a monogenic cerebral small-vessel disease. In unselected patients with CADASIL, brain atrophy and lacunes are the main imaging correlates of disease severity, but MR imaging correlates of reaction time in mildly affected patients are unknown. We hypothesized that reaction time is independently associated with the corpus callosum area in the early clinical stages of CADASIL...
September 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28911268/apathy-not-depressive-symptoms-as-a-predictor-of-semantic-and-phonemic-fluency-task-performance-in-stroke-and-transient-ischemic-attack
#20
Keera N Fishman, Andrea R Ashbaugh, Krista L Lanctôt, Megan L Cayley, Nathan Herrmann, Brian J Murray, Michelle Sicard, Karen Lien, Demetrios J Sahlas, Richard H Swartz
OBJECTIVES: This study examined the relationship between apathy and cognition in patients with cerebrovascular disease. Apathy may result from damage to frontal subcortical circuits causing dysexecutive syndromes, but apathy is also related to depression. We assessed the ability of apathy to predict phonemic fluency and semantic fluency performance after controlling for depressive symptoms in 282 individuals with stroke and/or transient ischemic attack. METHOD: Participants (N = 282) completed the Phonemic Fluency Test, Semantic Fluency Test, Center for Epidemiologic Studies Depression Scale, and Apathy Evaluation Scale...
September 15, 2017: Journal of Clinical and Experimental Neuropsychology
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