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https://www.readbyqxmd.com/read/30212839/apathy-in-rapid-eye-movement-sleep-behaviour-disorder-is-associated-with-serotonin-depletion-in-the-dorsal-raphe-nucleus
#1
Thomas R Barber, Ludovica Griffanti, Kinan Muhammed, Daniel S Drew, Kevin M Bradley, Daniel R McGowan, Marie Crabbe, Christine Lo, Clare E Mackay, Masud Husain, Michele T Hu, Johannes C Klein
Apathy is a common and under-recognized disorder that often emerges in the prodromal phase of Parkinsonian diseases. The mechanism by which this occurs is not known, but recent evidence from patients with established Parkinson's disease suggests that serotonergic dysfunction may play a role. The integrity of the raphe serotonergic system can be assessed alongside dopaminergic basal ganglia imaging using the radioligand 123I-ioflupane, which binds both serotonin and dopamine transporters. To investigate the relative roles of these neurotransmitters in prodromal parkinsonism, we imaged patients with idiopathic rapid eye movement sleep behaviour disorder, the majority of whom will develop a parkinsonian disorder in future...
September 12, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30211612/executive-impairment-is-associated-with-unawareness-of-neuropsychiatric-symptoms-in-premanifest-and-early-huntington-s-disease
#2
Sophie C Andrews, David Craufurd, Alexandra Durr, Blair R Leavitt, Raymund A Roos, Sarah J Tabrizi, Julie C Stout
OBJECTIVE: Unawareness of neuropsychiatric symptoms appears to be common in Huntington's disease (HD), but the clinical correlates of unawareness are unclear. Identifying predictors of unawareness is important for improving diagnosis of neuropsychiatric symptoms, and cognitive impairment, specifically executive impairment, may be a potential important predictor of unawareness. The authors examined whether unawareness of neuropsychiatric symptoms is more common in early HD compared to premanifest HD, and whether executive task performance was associated with awareness, independent of demographic, motor or mood variables...
September 13, 2018: Neuropsychology
https://www.readbyqxmd.com/read/30192444/transdermal-nicotine-for-the-treatment-of-mood-and-cognitive-symptoms-in-nonsmokers-with-late-life-depression
#3
Jason A Gandelman, Hakmook Kang, Ashleigh Antal, Kimberly Albert, Brian D Boyd, Alexander C Conley, Paul Newhouse, Warren D Taylor
OBJECTIVE: Late-life depression (LLD) is characterized by poor antidepressant response and cognitive dysfunction. This study examined whether transdermal nicotine benefits mood symptoms and cognitive performance in LLD. METHODS: In a 12-week open-label outpatient study conducted between November 2016 and August 2017, transdermal nicotine was given to 15 nonsmoking older adults (≥ 60 years of age). Eligible participants met DSM-IV-TR criteria for major depressive disorder with ≥ 15 on the Montgomery-Asberg Depression Rating scale (MADRS) and endorsed subjective cognitive impairment...
August 28, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/30183371/self-awareness-deficits-associated-with-lower-treatment-motivation-in-cocaine-addiction
#4
Benjamin R Castine, Natalia Albein-Urios, Oscar Lozano-Rojas, Jose M Martinez-Gonzalez, Jakob Hohwy, Antonio Verdejo-Garcia
BACKGROUND: Individuals with cocaine use disorder (CUD) often display behaviours that are paradoxically misaligned with their situation. Typical examples include poor treatment motivation and inconsistent self-reported craving. These behaviours may reflect impairments in the awareness of one's own behaviour. OBJECTIVES: We examined whether impaired self-awareness of addiction-related frontostriatal dysfunction (i.e., symptoms of apathy, disinhibition, and executive dysfunction) was associated with treatment motivation and craving...
September 5, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/30178175/comparative-cognitive-and-neuropsychiatric-profiles-between-parkinson-s-disease-multiple-system-atrophy-and-progressive-supranuclear-palsy
#5
Gabriella Santangelo, Sofia Cuoco, Maria Teresa Pellecchia, Roberto Erro, Paolo Barone, Marina Picillo
BACKGROUND: Parkinsonian syndromes are characterized by a wide spectrum of non-motor symptoms. A few studies explored cognitive deficits and neuropsychiatric symptoms in atypical parkinsonism compared to Parkinson's disease (PD). The study was performed to identify cognitive and neuropsychiatric differences between PD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and to evaluate the influence of clinical features, depressive symptomatology and apathy on cognitive performances in the three groups...
September 3, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30167880/risk-factors-of-suicidal-ideation-in-huntington-s-disease-literature-review-and-data-from-enroll-hd
#6
Philipp Honrath, Imis Dogan, Olga Wudarczyk, Katharina S Görlich, Mikhail Votinov, Cornelius J Werner, Beate Schumann, Rena T Overbeck, Jörg B Schulz, Bernhard G Landwehrmeyer, Raquel E Gur, Ute Habel, Kathrin Reetz
Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of suicidal ideation in premanifest and manifest patients and re-evaluate them using the largest currently existing clinical dataset from the ongoing observational study "Enroll-HD" (N = 5709)...
August 27, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30146591/antidepressants-for-depression-apathy-and-gait-instability-in-parkinson-s-disease-a-multicenter-randomized-study
#7
Makio Takahashi, Hayato Tabu, Akihiko Ozaki, Toshiaki Hamano, Takao Takeshima
Objective Depression, apathy, and gait instability are cardinal symptoms in patients with Parkinson' s disease (PD). Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are used for treating the psychiatric symptoms of PD. This is the first prospective randomized study to compare the efficacy of an SNRI (duloxetine) with SSRIs (paroxetine, escitalopram) in improving depressive symptoms and apathy (primary) and freezing of gait (FOG; secondary) in patients with PD...
August 24, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30123816/apathy-in-alzheimer-s-disease
#8
REVIEW
Lisa Nobis, Masud Husain
Apathy is the most common neuropsychiatric symptom in patients with Alzheimer's disease (AD). The presence of apathy has been related to greater caregiver distress, decreased quality of life, and increased morbidity. Here we review the most recent studies on this neuropsychiatric syndrome, focusing on prevalence, impact on quality of life, behavioural and neuroimaging studies, and treatment options. The results of some investigations on the behavioural and neuroanatomical profile of apathy in AD point to a role of frontostriatal circuits, specifically involving the anterior cingulate cortex...
August 2018: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/30123151/structured-floral-arrangement-program-benefits-in-patients-with-neurocognitive-disorder
#9
Hiroko Mochizuki-Kawai, Izumi Kotani, Satoshi Mochizuki, Yuriko Yamakawa
We attempted to clarify positive benefits in cognitive abilities and motivation during our cognitive intervention [structured floral arrangement (SFA) program] for patients with neurocognitive disorder due to stroke, traumatic brain injury (TBI), and other related disorders. In this SFA program, participants are required to arrange cut flowers and leaves on absorbent foam according to an instruction sheet. In a previous study of patients with schizophrenia, our SFA program encouraged participants and contributed to stimulating their visuospatial process and memory...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30107062/beneficial-effects-of-bilateral-subthalamic-stimulation-on-alexithymia-in-parkinson-s-disease
#10
Haidar S Dafsari, K Ray Chaudhuri, Picabo Mahlstedt, Lena Sachse, Julia K Steffen, Jan Niklas Petry-Schmelzer, Till A Dembek, Paul Reker, Michael T Barbe, Veerle Visser-Vandewalle, Gereon R Fink, Lars Timmermann
BACKGROUND: In advanced Parkinson's disease (PD), subthalamic neurostimulation (STN-DBS) improves quality of life (QoL), motor, and non-motor symptoms. However, its effect on alexithymia and its relationship to other neuropsychiatric symptoms and quality of life in PD is unclear. METHODS: In this prospective, observational study of 39 PD patients undergoing STN-DBS, we examined PDQuestionnaire-8 (PDQ-8), Toronto Alexithymia Scale-20 (TAS-20), Hospital Anxiety and Depression Scale (HADS), Self-Report Manic Inventory (SRMI), Apathy Evaluation Scale (AES), Unified PD Rating Scale-activities of daily living, -motor examination, and -complications (UPDRS-II/-III/-IV), and levodopa-equivalent daily dose (LEDD) preoperatively and at 5-month follow-up...
August 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30106999/willingness-to-pay-and-moral-stance-the-case-of-farm-animal-welfare-in-germany
#11
Ulrich J Frey, Frauke Pirscher
This study examines the impact of ethical attitude on the willingness to pay for farm animal welfare improvement in Germany. Little is known about the pluralism of moral attitudes that may exist behind farm animal welfare issues and its relationship to customers' willingness to pay for it. Via a large survey (n = 1334) we are able to identify different moral dimensions by employing validated scales. We find utilitarian alongside deontological attitudes as well as a mixture of both. Thus, presupposing a standard moral attitude is too simple...
2018: PloS One
https://www.readbyqxmd.com/read/30103612/apathy-in-preclinical-alzheimer-s-disease-psychometric-validation-of-the-apathy-evaluation-scale
#12
Emre Umucu, Mary Wyman, Beatrice Lee, Megan Zuelsdorff, Susan Flowers Benton, Naomi Nystrom, Sterling C Johnson, Cynthia M Carlsson, Sanjay Asthana, Carey E Gleason
OBJECTIVES: The purpose of the present study was to validate the Apathy Evaluation Scale, self-rated version (AES-S), and assess the severity of apathy in a cognitively healthy middle-aged cohort at risk for Alzheimer's disease (AD). METHOD: Three hundred and sixteen middle-aged adults were selected to represent a subset of the Wisconsin Alzheimer's Disease Research Center Clinical Core: the Investigating Memory in People At-risk, Causes and Treatments cohort. RESULTS: An exploratory factor analysis (EFA) with varimax rotation identified 3 subscales: apathy, disinterest, and social withdrawal factors...
August 14, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/30103335/social-dysfunction-in-older-age-and-relationships-with-cognition-depression-and-apathy-the-greatage-study
#13
Madia Lozupone, Francesco Panza, Marco Piccininni, Massimiliano Copetti, Rodolfo Sardone, Bruno P Imbimbo, Eleonora Stella, Francesca D'Urso, Maria Rosaria Barulli, Petronilla Battista, Alessandra Grasso, Rosanna Tortelli, Rosa Capozzo, Francesco Coppola, Daniela Isabel Abbrescia, Antonello Bellomo, Gianluigi Giannelli, Nicola Quaranta, Davide Seripa, Giancarlo Logroscino
BACKGROUND: Most studies focused on only one measure of social dysfunction in older age, without proper validation and distinction across different dimensions including subjectivity, structural, and functional aspects. OBJECTIVE: We sought to validate the Social Dysfunction Rating Scale (SDRS) and its factorial structure, also determining the association of SDRS with cognitive functions, global psychopathology, and social deprivation. METHODS: The SDRS was administered to 484 Italian community-dwelling elderly, recruited in the GreatAGE study, a population-based study on aging conducted in Castellana Grotte, Bari, Southern Italy...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/30099246/rotigotine-transdermal-patch-for-the-treatment-of-neuropsychiatric-symptoms-in-parkinson-s-disease-a-meta-analysis-of-randomized-placebo-controlled-trials
#14
Hao-Tian Wang, Li Wang, Yi He, Gang Yu
OBJECTIVE: To systematically evaluate and quantify the effects of rotigotine treatment on neuropsychiatric symptoms in Parkinson's disease (PD). METHODS: We searched for articles involving randomized controlled trials (RCTs) that were published before September 1, 2017, in the PubMed, Clinical Trials, Cochrane Library, and EMBASE databases. A meta-analysis was performed to estimate changes in the scales used to assess neuropsychiatric symptoms. The data were analyzed using Cochrane Collaboration's Review Manager 5...
October 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30084177/medial-temporal-lobe-atrophy-is-independently-associated-with-behavioural-and-psychological-symptoms-in-alzheimer-s-disease
#15
José María García-Alberca, Mercedes Florido, Marta Cáceres, Alicia Sánchez-Toro, José Pablo Lara, Natalia García-Casares
AIM: Evidence describing the contribution of cerebral white matter disease and medial temporal atrophy (MTA) to behavioural and psychological symptoms of dementia (BPSD) has been conflicting. The aim of this study was to assess the relationship of white matter hyperintensities (WMH) and MTA observed on magnetic resonance imaging with BPSD among patients with Alzheimer's disease. METHODS: In a cross-sectional study of a prospective cohort of patients attending a memory clinic, 46 patients with probable Alzheimer's disease (mean age: 72...
August 6, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/30082208/psychometric-properties-of-an-abbreviated-version-of-the-apathy-evaluation-scale-for-parkinson-disease-aes-12pd
#16
Yuliya Stankevich, Ulrike Lueken, Monika Balzer-Geldsetzer, Richard Dodel, Susanne Gräber-Sultan, Daniela Berg, Inga Liepelt-Scarfone, Rüdiger Hilker-Roggendorf, Elke Kalbe, Oliver Kaut, Brit Mollenhauer, Kathrin Reetz, Eva Schäffer, Nele Schmidt, Jörg B Schulz, Annika Spottke, Karsten Witt, Katharina Linse, Alexander Storch, Oliver Riedel
BACKGROUND: Apathy is a frequent symptom in Parkinson's disease (PD), substantially aggravating the course of PD. Regarding the accumulating evidence of the key role of apathy in PD, time-efficient assessments are useful for fostering progress in research and treatment. The Apathy Evaluation Scale (AES) is widely used for the assessment of apathy across different nosologies. OBJECTIVE: To facilitate the application of the AES in PD, we reduced the AES to two-thirds its length and validated this abbreviated version...
June 30, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/30081208/consequences-of-persistent-depression-and-apathy-in-first-episode-psychosis-a-one-year-follow-up-study
#17
Siv Hege Lyngstad, Erlend Strand Gardsjord, Carmen Simonsen, Magnus Johan Engen, Kristin Lie Romm, Ingrid Melle, Ann Færden
BACKGROUND: Apathy and depression are prevalent in first-episode psychosis (FEP), have overlapping clinical features and are linked to social dysfunction, with indications that persisting symptoms have an even more negative impact. Our objective was to investigate the prevalence of persisting depression (PD), persisting apathy (PA), to what extent they overlap and their relative associations to functioning during a one-year follow-up. METHODS: One hundred and twenty-five participants with a FEP were recruited, and 88 (70%) were reassessed at follow-up...
October 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/30073726/defining-neuropsychiatric-inventory-scale-differences-across-frontotemporal-dementia-syndromes
#18
Konstantina G Yiannopoulou, John D Papatriantafyllou, Apostolia Ghika, Niki Tsinia, Eudoxia Lykou, Evaggelia Hatziantoniou, Dimitrios Agiomyrgiannakis, Andreas Kyrozis, Sokratis G Papageorgiou
AIM: The aim of this study was to assess the ability of Neuropsychiatric Inventory (NPI) scale profiles to differentiate between distinct frontotemporal dementia (FTD) subtypes. METHODS: The NPI was used to assess 311 older patients who had been clinically diagnosed with FTD. FTD subtypes included behavioural variant FTD (bvFTD, n = 121), primary progressive aphasia (semantic variant (n = 69), non-fluent agrammatic variant (n = 31), and logopenic variant (n = 0)), FTD-motor neuron disease (n = 4), progressive supranuclear palsy (n = 43), and corticobasal syndrome (n = 43)...
August 2, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/30066463/an-intervention-programme-for-caregivers-of-dementia-patients-with-frontal-behavioural-changes-an-explorative-study-with-controlled-effect-on-sense-of-competence
#19
Flora Gossink, Yolande Pijnenburg, Philip Scheltens, Aafke Pera, Rikie Kleverwal, Nicole Korten, Max Stek, Rose-Marie Dröes, Annemiek Dols
AIM: Caregivers of dementia patients experience high levels of burden; this is especially true of caregivers of dementia patients with behavioural problems. As intervention studies for these caregivers are still lacking, we conducted an explorative pilot study into the efficacy of a support programme. METHODS: Participants were caregivers of dementia patients affected by apathy, disinhibition, and/or stereotypical behaviour. All patients had a Frontal Behavioural Inventory score of 11 or higher...
July 31, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/30056433/dopaminergic-effect-on-non-motor-symptoms-in-late-stage-parkinson-s-disease
#20
Kristina Rosqvist, Per Odin, Peter Hagell, Susanne Iwarsson, Maria H Nilsson, Alexander Storch
BACKGROUND: Non-motor symptoms (NMS) are common in late stage Parkinson's disease (PD), as the frequency and severity of most of these symptoms increase with advancing disease. OBJECTIVE: To assess effect of dopaminergic therapy on NMS in late stage PD and to investigate relationships between dopaminergic effect on NMS and on motor function. METHOD: Thirty PD patients in Hoehn and Yahr (HY) stages IV and V in "on" were included. Dopaminergic effect on non-motor symptomatology was assessed by the modified version of the Non-Motor Symptoms Scale (NMSS) in the "off" and the "on" state during a standardized L-dopa test, in parallel also assessing motor function...
2018: Journal of Parkinson's Disease
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