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https://www.readbyqxmd.com/read/29335041/clinical-correlates-of-resilience-factors-in-geriatric-depression
#1
Kelsey T Laird, Helen Lavretsky, Pattharee Paholpak, Roza M Vlasova, Michael Roman, Natalie St Cyr, Prabha Siddarth
BACKGROUND: Traditional perspectives conceptualize resilience as a trait and depression as resulting from resilience deficiency. However, research indicates that resilience varies substantially even among adults who are clinically depressed, as well as across the lifespan of an individual. Few studies have investigated resilience in depression, and even fewer have examined resilience in depressed older adults. METHODS: Three hundred thirty-seven adults ≥60 years with major depressive disorder completed the Connor-Davidson Resilience Scale (CD-RISC) and measures of mental health, quality of life (QOL), and medical comorbidity...
January 16, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29330419/parkinson-disease-with-constipation-clinical-features-and-relevant-factors
#2
Qiu-Jin Yu, Shu-Yang Yu, Li-Jun Zuo, Teng-Hong Lian, Yang Hu, Rui-Dan Wang, Ying-Shan Piao, Peng Guo, Li Liu, Zhao Jin, Li-Xia Li, Piu Chan, Sheng-Di Chen, Xiao-Min Wang, Wei Zhang
Constipation is one of the most frequent non-motor symptoms of Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not to be reported in time. The relationships between constipation and demographic variables, motor symptoms and other non-motor symptoms of PD are still unknown. PD patients were evaluated by diagnostic criteria of functional constipation in Rome III and divided into PD with constipation (PD-C) and PD with no constipation (PD-NC) groups. PD patients were assessed by rating scales of motor symptoms and other non-motor symptoms, activity of daily living and quality of life...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325447/longitudinal-association-of-amyloid-beta-and-anxious-depressive-symptoms-in-cognitively-normal-older-adults
#3
Nancy J Donovan, Joseph J Locascio, Gad A Marshall, Jennifer Gatchel, Bernard J Hanseeuw, Dorene M Rentz, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To understand the role of depressive symptoms in preclinical Alzheimer's disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in cognitively normal older adults. The study objective was to examine associations of brain amyloid beta and longitudinal measures of depression and depressive symptom clusters in a cognitively normal sample of older adults. METHOD: A total of 270 community-dwelling, cognitively normal elderly individuals underwent baseline Pittsburgh compound B (PiB) positron emission tomography (PET) measures of cortical aggregate amyloid beta and annual assessments with the 30-item Geriatric Depression Scale (GDS)...
January 12, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29316566/double-anterior-stereotactic-cingulotomy-for-intractable-oncological-pain
#4
Ido Strauss, Assaf Berger, Shlomit Ben Moshe, Michal Arad, Uri Hochberg, Tal Gonen, Rotem Tellem
BACKGROUND: Stereotactic anterior cingulotomy has been used in the treatment of patients suffering from refractory oncological pain due to its effects on pain perception. However, the optimal targets as well as suitable candidates and outcome measures have not been well defined. We report our initial experience in the ablation of 2 cingulotomy targets on each side and the use of the Brief Pain Inventory (BPI) as a perioperative assessment tool. METHODS: A retrospective review of all patients who underwent stereotactic anterior cingulotomy in our Department between November 2015 and February 2017 was performed...
January 10, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29305655/chrfam7a-gene-expression-in-schizophrenia-clinical-correlates-and-the-effect-of-antipsychotic-treatment
#5
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
January 5, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29282408/behavioural-and-psychological-symptoms-of-dementia-correlates-and-impact-on-caregiver-distress
#6
Adreesh Mukherjee, Atanu Biswas, Arijit Roy, Samar Biswas, Goutam Gangopadhyay, Shyamal Kumar Das
Aims: To evaluate the behavioural and psychological symptoms of dementia (BPSD), to determine their correlation with types and stages of dementia and patient demographics, and to assess the impact on caregiver distress. Methods: This cross-sectional study recruited consecutive dementia patients and caregivers who attended our cognitive clinic. Standard criteria were used to classify types of dementia. BPSD were assessed with the Neuropsychiatric Inventory, and its distress scale was used for caregiver distress...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29282160/emotion-recognition-correlates-with-social-neuropsychiatric-dysfunction-in-huntington-s-disease
#7
Clare L Kempnich, Sophie C Andrews, Fiona Fisher, Dana Wong, Nellie Georgiou-Karistianis, Julie C Stout
OBJECTIVES: People with Huntington's disease (HD) experience poor social quality of life, relationship breakdown, and social withdrawal, which are mediated to some extent by socially debilitating neuropsychiatric symptoms, such as apathy and disinhibition. Social cognitive symptoms, such as impaired emotion recognition, also occur in HD, however, the extent of their association with these socially debilitating neuropsychiatric symptoms is unknown. Our study examined the relationship between emotion recognition and symptom ratings of apathy and disinhibition in HD...
December 28, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29278897/reliability-of-the-apathy-evaluation-scale-in-myotonic-dystrophy-type-1
#8
Benjamin Gallais
BACKGROUND: Apathy is a common debilitating symptom of myotonic dystrophy type 1 (DM1). The Apathy Evaluation Scale (AES) has been identified as a promising measurement instrument to be used in DM1 but its metrological properties must be further documented. OBJECTIVE: To determine the internal consistency of the Self (AES-S), Informant (AES-I), and Clinician (AES-C) versions of the AES and to assess the test-retest reliability, standard error of measurement, and minimal detectable change of the AES-S and AES-I in a sample of DM1 patients and their related informants...
December 20, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29243529/avolition-apathy-and-white-matter-connectivity-in-schizophrenia-reduced-fractional-anisotropy-between-amygdala-and-insular-cortex
#9
Antonella Amodio, Mario Quarantelli, Armida Mucci, Anna Prinster, Andrea Soricelli, Annarita Vignapiano, Giulia Maria Giordano, Eleonora Merlotti, Alessia Nicita, Silvana Galderisi
The avolition/apathy domain of negative symptoms includes motivation- and pleasure-related impairments. In people with schizophrenia, structural and functional abnormalities were reported in key regions within the motivational reward system, including ventral-tegmental area (VTA), striatum (especially at the level of the nucleus accumbens, NAcc), orbitofrontal cortex (OFC), as well as amygdala (Amy) and insular cortex (IC). However, the association of the reported abnormalities with avoliton-apathy is still controversial...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29238748/non-motor-symptoms-in-progressive-supranuclear-palsy-prevalence-and-severity
#10
Fabiana Giada Radicati, Pablo Martinez Martin, Chiara Fossati, Kallol Ray Chaudhuri, Margherita Torti, Carmen Rodriguez Blazquez, Laura Vacca, Fabrizio Stocchi
NMSs have been extensively studied in PD patients but not in other forms of parkinsonism such as Progressive Supranuclear Palsy (PSP). The primary objective of this study was to analyze the frequency, severity and the type of non-motor symptoms (NMS) in PSP patients using the non-motor symptoms scale (NMSS). The secondary objective was to differentiate NMS between PSP and Parkinson's disease (PD). We enrolled in this cross-sectional study 50 consecutive PSP and 100 matched Parkinson's disease (PD) patients, in the proportion PSP/PD = 1/2, matched in age, sex, and disease duration...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29210282/neuropsychiatric-profile-in-early-versus-late-onset-alzheimer-s-disease
#11
Maria do Céu Ferreira, Maria João Abreu, Célia Machado, Beatriz Santos, Álvaro Machado, Ana Sofia Costa
BACKGROUND: The aim of this study was to investigate the frequency and severity of neuropsychiatric symptoms (NPS) in patients with early onset Alzheimer's disease (EAOD) and late onset AD (LOAD). METHODS: Patients were selected from a specialized memory outpatient clinic. The Mini-Mental State Examination, the Neuropsychiatric Inventory (NPI), and the Global Deterioration Scale results were analyzed. RESULTS: By comparing EOAD (n = 35) and LOAD (n = 35) patients, no significant differences were found in clinical or demographic variables, matched for sex, education, and disease severity...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29196576/apathy-is-associated-with-incident-dementia-in-community-dwelling-older-people
#12
Jan Willem van Dalen, Lennard L Van Wanrooij, Eric P Moll van Charante, Edo Richard, Willem A van Gool
OBJECTIVE: To assess whether apathy and depressive symptoms are independently associated with incident dementia during 6-year follow-up in a prospective observational population-based cohort study. METHODS: Participants were community-dwelling older people in the Prevention of Dementia by Intensive Vascular Care trial, aged 70-78 years, without dementia at baseline. Apathy and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS-15)...
January 2, 2018: Neurology
https://www.readbyqxmd.com/read/29195165/psychometric-evaluation-of-the-temporal-experience-of-pleasure-scale-teps-in-a-german-sample
#13
Joe J Simon, Johannes Zimmermann, Sheila A Cordeiro, Ina Marée, David E Gard, Hans-Christoph Friederich, Matthias Weisbrod, Stefan Kaiser
Anhedonia, or the inability to experience pleasure, is commonly observed in schizophrenia. It has been suggested that patients with schizophrenia are unable to predict future pleasurable events, but show intact experience of in-the-moment pleasure. Therefore, the Temporal Experience of Pleasure Scale (TEPS), a self-report measure allowing the assessment of anticipatory and consummatory pleasure, has been developed. To validate the German version of the TEPS, we recruited 59 healthy control participants and 51 patients with schizophrenia or schizoaffective disorder who completed the TEPS as well as a battery of psychometric tests to assess psychopathology, in particular self-rated anhedonia and clinician-rated apathy as well as overall measures of negative symptoms...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29194534/why-not-try-harder-computational-approach-to-motivation-deficits-in-neuro-psychiatric-diseases
#14
Mathias Pessiglione, Fabien Vinckier, Sébastien Bouret, Jean Daunizeau, Raphaël Le Bouc
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric diseases. Even when they are not the core symptom, they reduce quality of life, compromise functional outcome and increase the burden for caregivers. They are currently assessed with clinical scales that do not give any mechanistic insight susceptible to guide therapeutic intervention. Here, we present another approach that consists of phenotyping the behaviour of patients in motivation tests, using computational models...
November 29, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29193182/cognitive-impairment-and-quality-of-life-in-patients-with-myotonic-dystrophy-type-1
#15
Haruo Fujino, Honoka Shingaki, Shugo Suwazono, Yukihiko Ueda, Chizu Wada, Takahiro Nakayama, Masanori P Takahashi, Osamu Imura, Tsuyoshi Matsumura
INTRODUCTION: This study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. METHODS: Sixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL...
November 28, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29192512/assessing-apathy-in-long-term-care-residents-with-dementia-who-should-be-the-rater
#16
Ying-Ling Jao, Kristine Williams, Jacqueline Mogle, Liza Behrens, Caroline McDermott
Background Apathy is prominent in persons with dementia and apathy assessment is challenging. It remains unclear who should conduct apathy assessments in long-term care settings for residents with moderate to advanced dementia. The Apathy Evaluation Scale (AES) is a widely used instrument and its use for long-term care residents with dementia needs to be further established. This study explored the relationship among apathy assessments conducted by family and clinical caregivers using the original AES (AES-18) and the nursing home version (AES-10)...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29189922/apathy-and-its-impact-on-patient-outcome-in-amyotrophic-lateral-sclerosis
#17
J Caga, S Hsieh, E Highton-Williamson, M C Zoing, E Ramsey, E Devenney, R M Ahmed, M C Kiernan
Apathy is one of the most common behavioural symptoms of amyotrophic lateral sclerosis (ALS), yet there are few studies that have investigated the relationship between apathy and quality of life (QOL) as they are experienced by the patient. A cohort of 60 ALS patients were evaluated using the Apathy Evaluation Scale which measured cognitive, behavioural, emotional and non-specific symptoms of apathy combined with the Personal Wellbeing Index, a multidimensional measure of QOL. The relationship between patient-rated apathy and QOL scores, controlling for potential clinical and psychological confounders were analysed using univariate and multivariate methods...
November 30, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29186356/altered-caudate-connectivity-is-associated-with-executive-dysfunction-after-traumatic-brain-injury
#18
Sara De Simoni, Peter O Jenkins, Niall J Bourke, Jessica J Fleminger, Peter J Hellyer, Amy E Jolly, Maneesh C Patel, James H Cole, Robert Leech, David J Sharp
Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour and personality. Frontal lobe injuries are associated with executive dysfunction, but it is unclear how these injuries relate to corticostriatal interactions that are known to play an important role in behavioural control. We hypothesized that executive dysfunction after traumatic brain injury would be associated with abnormal corticostriatal interactions, a question that has not previously been investigated...
November 23, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29148293/quantity-of-movement-as-a-measure-of-engagement-for-dementia-the-influence-of-motivational-disorders
#19
Giulia Perugia, Daniel Rodríguez-Martín, Marta Díaz Boladeras, Andreu Català Mallofré, Emilia Barakova, Matthias Rauterberg
Engagement in activities is crucial to improve quality of life in dementia. Yet, its measurement relies exclusively on behavior observation and the influence that behavioral and psychological symptoms of dementia (BPSD) have on it is overlooked. This study investigated whether quantity of movement, gauged with a wrist-worn accelerometer, could be a sound measure of engagement and whether apathy and depression negatively affected engagement. Fourteen participants with dementia took part in 6 sessions of activities: 3 of cognitive games (eg, jigsaw puzzles) and 3 of robot play (Pleo)...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29143702/association-between-altered-neurochemical-metabolites-and-apathy-in-patients-with-alzheimer-s-disease
#20
Yi-Chun Yeh, Chun-Wei Li, Yu-Ting Kuo, Mei-Feng Huang, Tai-Ling Liu, Twei-Shiun Jaw, Yi-Hsin Yang, Kuang-Che Kuo, Cheng-Sheng Chen
BACKGROUND: Apathy is a condition characterized by a lack of motivation that manifests in emotional, behavioral, and cognitive domains. Although previous studies have indicated that apathy is associated with frontal lesions, few studies have focused on the different subdomains of apathy, and no in vivo human biochemical data have been obtained to examine the neurochemical changes related to apathy in patients with Alzheimer's disease (AD). Thus, we investigated the frontal neurochemical alterations related to apathy among patients with AD using proton magnetic resonance spectroscopy (1H MRS)...
November 16, 2017: International Psychogeriatrics
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