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https://www.readbyqxmd.com/read/28089264/development-and-validation-of-the-deep-brain-stimulation-impairment-scale-dbs-is
#1
Franziska Maier, Catharine J Lewis, Carsten Eggers, Andrea A Kühn, Henriette Krug, Jens Volkmann, Anna D Kirsch, Lars Wojtecki, Alfons Schnitzler, Günther Deuschl, Joachim K Krauss, Christiane Woopen, Lars Timmermann
BACKGROUND: Bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) has considerable influence on motor and non-motor symptoms in Parkinson's disease (PD). While improvements in motor functioning can be easily assessed with general quality of life questionnaires, the measurement of specific STN-DBS-associated impairments often remains insufficient. Hence, we aimed to develop a questionnaire that measures STN-DBS-related impairments. METHODS: The development of the (STN-)DBS Impairment Scale (DBS-IS) consisted of four steps...
January 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28067961/quality-of-life-in-relation-to-neuropsychiatric-symptoms-in-alzheimer-s-disease-5-year-prospective-alsova-cohort-study
#2
Kristiina Hongisto, Ilona Hallikainen, Tuomas Selander, Soili Törmälehto, Saku Väätäinen, Janne Martikainen, Tarja Välimäki, Sirpa Hartikainen, Jaana Suhonen, Anne M Koivisto
OBJECTIVE: To examine the association between neuropsychiatric symptoms (NPS) with self- and caregiver-rated Quality of Life (QoL) for patients with Alzheimer's disease (AD) during a 5-year follow-up. METHODS: The ALSOVA 5-year follow-up study included, at baseline, 236 patients with either very mild (Clinical Dementia Rating Scale (CDR) 0.5), or mild (CDR 1) AD, together with their caregivers from three Finnish hospital districts. QoL was evaluated using patient self-reported, and caregiver-rated, QoL in AD (QoL-AD) scores...
January 9, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28039296/effectiveness-of-senior-dance-on-risk-factors-for-falls-in-older-adults-danse-a-study-protocol-for-a-randomised-controlled-trial
#3
Marcia R Franco, Catherine Sherrington, Anne Tiedemann, Leani S Pereira, Monica R Perracini, Claudia R S Faria, Rafael Z Pinto, Carlos M Pastre
INTRODUCTION: Strong evidence shows that exercise is effective to improve fall risk factors among older people. However, older people's participation and adherence to exercise programmes is suboptimal. Type of exercise and apathy are reported to be barriers to exercise participation, suggesting that new effective interventions are needed. The primary aim of this randomised controlled trial is to investigate the effect of Senior Dance plus brief education for falls prevention on balance among people aged 60 years or over, compared with a control group receiving only brief education...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28017247/clinical-characteristics-of-parkinsonism-in-frontotemporal-dementia-according-to-subtypes
#4
Hee Kyung Park, Kee Hyung Park, Bora Yoon, Jae-Hong Lee, Seong Hye Choi, Jee H Joung, Soo Jin Yoon, Byeong C Kim, Seung Hyun Kim, Eun-Joo Kim, Duk L Na, Kyung Won Park
BACKGROUND: We investigated the prevalence of parkinsonism in frontotemporal dementia (FTD) subtypes and the cognitive and behavioral differences between FTD with and without parkinsonism in a well-structured, prospective cohort. METHODS: One hundred and ninety-one FTD patients were enrolled and all patients underwent comprehensive neurological evaluations, neuropsychological tests, and the Unified Parkinson's Disease Rating Scale. RESULTS: The prevalence of parkinsonism was 38...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28009676/effectiveness-of-meaningful-occupation-interventions-for-people-living-with-dementia-in-residential-aged-care-a-systematic-review
#5
Catherine Travers, Deborah Brooks, Sonia Hines, Maria O'Reilly, Mitchell McMaster, Wei He, Margaret MacAndrew, Elaine Fielding, Lina Karlsson, Elizabeth Beattie
BACKGROUND: The ability to participate in valued activities, whether for work, leisure or family, is an important aspect of personal identity. In dementia, progressive memory loss means that abilities developed over a lifetime begin to be lost as well, contributing to the loss of self and identity. Some studies have reported that activities or interventions tailored to be meaningful to the person with dementia (defined as any activity important to the individual) are more effective in addressing behavioral and psychological symptoms of dementia (BPSD) and improving quality of life (QoL) than those that are not so tailored...
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27993522/non-motor-symptoms-and-the-quality-of-life-in-multiple-system-atrophy-with-different-subtypes
#6
LingYu Zhang, Bei Cao, RuWei Ou, Qian-Qian Wei, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
BACKGROUND: The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes. METHODS: A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA. RESULTS: The most prevalent NMS domain was urinary (91...
December 13, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27983562/plasma-cytokine-levels-in-relation-to%C3%A2-neuropsychiatric-symptoms-and-cognitive-dysfunction-in-huntington-s-disease
#7
Jos A Bouwens, Erik van Duijn, Christa M Cobbaert, Raymund A C Roos, Roos C van der Mast, Erik J Giltay
BACKGROUND: In Huntington's disease (HD) the innate immune system is activated, as reflected by increased plasma levels of different cytokines. OBJECTIVE: To explore whether increased cytokine levels are associated with neuropsychiatric symptoms and cognitive dysfunction in HD mutation carriers. METHOD: Plasma cytokine levels of TNF-alpha, interleukin (IL)-1ra, IL-1β, IL-5, IL-6, IL-8 and Il-10 were assessed in 124 HD mutation carriers at two time points 2 years apart (totalling 214 observations)...
December 15, 2016: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/27965058/apathy-and-higher-level-of-gait-control-in-normal-pressure-hydrocephalus
#8
Gilles Allali, Magali Laidet, Stéphane Armand, Arnaud Saj, Paul Krack, Frédéric Assal
Apathy represents the most common behavioral disturbance in patients with suspicion of idiopathic normal pressure hydrocephalus (iNPH) and has a major impact on quality of life. However, its impact on gait -the hallmark motor disturbance of iNPH - has never been studied yet. This study aims to evaluate the impact of apathy on higher level of gait control in patients with suspicion of iNPH. Stride time variability (STV), a marker of higher level of gait control, was quantified during usual walking (single task) and during walking while performing simultaneously cognitive tasks (dual task) of counting and verbal fluency...
December 11, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27876020/the-brief-negative-symptom-scale-validation-of-the-german-translation-and-convergent-validity-with-self-rated-anhedonia-and-observer-rated-apathy
#9
Martin Bischof, Caitriona Obermann, Matthias N Hartmann, Oliver M Hager, Matthias Kirschner, Agne Kluge, Gregory P Strauss, Stefan Kaiser
BACKGROUND: Negative symptoms are considered core symptoms of schizophrenia. The Brief Negative Symptom Scale (BNSS) was developed to measure this symptomatic dimension according to a current consensus definition. The present study examined the psychometric properties of the German version of the BNSS. To expand former findings on convergent validity, we employed the Temporal Experience Pleasure Scale (TEPS), a hedonic self-report that distinguishes between consummatory and anticipatory pleasure...
November 22, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27865517/effects-of-melatonin-in-the-treatment-of-asthenia-in-aneurysmal-subarachnoid-hemorrhage
#10
V Gilard, F-X Ferracci, O Langlois, S Derrey, F Proust, S Curey
BACKGROUND AND OBJECTIVES: Survivors of aneurysmal subarachnoid hemorrhage (aSAH) commonly experience sleep disorders resulting in asthenia. The objective of this prospective study was to determine, in a cohort of patients with treated ruptured intracranial aneurysm (IA), the proportion of asthenia at 2months, in a cohort of patients treated with melatonin and in a control cohort. PATIENTS AND METHODS: Twenty consecutive patients admitted for the treatment of ruptured IA and able to answer a standardized questionnaire were included in the study...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27844173/assessment-of-apathy-independent-of-physical-disability-validation-of-the-dimensional-apathy-scale-in-italian-healthy-sample
#11
Gabriella Santangelo, Simona Raimo, Mattia Siciliano, Alfonsina D'Iorio, Fausta Piscopo, Sofia Cuoco, Marianna Bottone, Francesca Trojsi, Dario Grossi, Luigi Trojano
Apathy is well described in neurodegenerative diseases characterized by motor disability; therefore, assessment of apathy avoiding possible confounding effects of motor impairments is necessary in neurological diseases. Recently, the Dimensional Apathy Scale (DAS) was developed to assess apathy as multifaceted construct, independent of physical disability. We developed the Italian version of the Dimensional Apathy Scale (I-DAS) and explored its psychometric properties in a sample of 309 healthy individuals...
November 14, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27798669/prefrontal-activity-and-connectivity-with-the-basal-ganglia-during-performance-of-complex-cognitive-tasks-is-associated-with-apathy-in-healthy-subjects
#12
Leonardo Fazio, Giancarlo Logroscino, Paolo Taurisano, Graziella Amico, Tiziana Quarto, Linda Antonella Antonucci, Maria Rosaria Barulli, Marina Mancini, Barbara Gelao, Laura Ferranti, Teresa Popolizio, Alessandro Bertolino, Giuseppe Blasi
OBJECTIVE: Convergent evidence indicates that apathy affects cognitive behavior in different neurological and psychiatric conditions. Studies of clinical populations have also suggested the primary involvement of the prefrontal cortex and the basal ganglia in apathy. These brain regions are interconnected at both the structural and functional levels and are deeply involved in cognitive processes, such as working memory and attention. However, it is unclear how apathy modulates brain processing during cognition and whether such a modulation occurs in healthy young subjects...
2016: PloS One
https://www.readbyqxmd.com/read/27721206/the-cortical-thickness-correlates-of-clinical-manifestations-in-the-mid-stage-sporadic-parkinson-s-disease
#13
Xia Deng, Chun-Yan Tang, Jie Zhang, Lei Zhu, Zun-Chun Xie, Hong-Han Gong, Xiang-Zuo Xiao, Ren-Shi Xu
The cortical thickness has gained an extensive attention as a pathological alteration of sporadic Parkinson's disease (sPD), the alteration of pathological cortical thickness may distinctly contribute to the consistent clinical manifestations. Therefore, we investigated the cortical thickness correlates of clinical manifestations in the mid-stage sPD from the Han population of Chinese mainland (HPCM). A sample of 67 mid-stage sPD patients and 35 matched controls from HPCM were performed a corticometry of magnetic resonance imaging (MRI) and the assessment of clinical manifestations including the demographic and disease-related characteristics, and underwent the final analysis of the cortical thickness correlates with the clinical manifestations...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27696678/effects-of-a-progressive-muscle-relaxation-intervention-on-dementia-symptoms-activities-of-daily-living-and-immune-function-in-group-home-residents-with-dementia-in-japan
#14
Shiho Ikemata, Yumiko Momose
AIM: To evaluate the effects of progressive muscle relaxation on the behavioral and psychological symptoms of dementia, activities of daily living, and immune function of elderly patients with dementia in group homes. METHODS: The participants were ranked by their group home unit. Odd ranks were assigned to the intervention group and even ranks to the control group. The intervention group participated in progressive muscle relaxation for 15 min each day for 90 days in the group environment; the control group members continued with their normal routine...
October 3, 2016: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/27678552/urine-ethanol-concentration-and-alcohol-hangover-severity
#15
Aurora Van de Loo, Marlou Mackus, Gerdien Korte-Bouws, Karel Brookhuis, Johan Garssen, Joris Verster
BACKGROUND: The aim of this study was to examine the relationship between urine ethanol concentration and alcohol hangover severity. METHODS: N = 36 healthy social drinkers participated in a naturalistic study, comprising a hangover day and a control day. N = 18 of them have regular hangovers (the hangover group), while the other N = 18 claim to be hangover immune (hangover-immune group). On each test day at 9.30 am, urine samples were collected. Participants rated their overall hangover severity on a scale from 0 (absent) to 10 (extreme), as well as 18 individual hangover symptoms...
January 2017: Psychopharmacology
https://www.readbyqxmd.com/read/27670392/fatigue-in-early-parkinson-s-disease-the-norwegian-parkwest-study
#16
S O Ongre, J P Larsen, O B Tysnes, K Herlofson
BACKGROUND AND PURPOSE: Fatigue is a common and disabling non-motor symptom in Parkinson's disease (PD). The pathogenesis is unknown, and the treatment options are limited. The aim of the present study was to investigate the development of fatigue during the first year after diagnosis. METHODS: The study design was a prospective, controlled population-based longitudinal cohort study, comprising 181 de novo, drug-naïve patients with PD and 162 control participants...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27663851/changes-in-mental-state-and-behaviour-in-huntington-s-disease
#17
REVIEW
Clare M Eddy, Ellice G Parkinson, Hugh E Rickards
Changes in mental state and behaviour have been acknowledged in Huntington's disease since the original monograph in 1872 provided evidence of disinhibition and impaired social cognition. Behavioural problems can manifest before obvious motor symptoms and are frequently the most disabling part of the illness. Although pharmacological treatments are used routinely for psychiatric difficulties in Huntington's disease, the scientific evidence base for their use is somewhat sparse. Moreover, effective treatments for apathy and cognitive decline do not currently exist...
November 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27659190/influence-of-small-vessel-disease-and-microstructural-integrity-on-neurocognitive-functioning-in-older-individuals-the-dante-study-leiden
#18
J E F Moonen, J C Foster-Dingley, A A van den Berg-Huijsmans, W de Ruijter, A J M de Craen, J van der Grond, R C van der Mast
BACKGROUND AND PURPOSE: Small vessel disease is a major cause of neurocognitive dysfunction in the elderly. Small vessel disease may manifest as white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and atrophy, all of which are visible on conventional MR imaging or as microstructural changes determined by diffusion tensor imaging. This study investigated whether microstructural integrity is associated with neurocognitive dysfunction in older individuals, irrespective of the conventional features of small vessel disease...
September 22, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27623026/caregiver-s-distress-related-to-the-patient-s-neuropsychiatric-symptoms-as-a-function-of-the-care-setting
#19
Laura Lorenzo-López, Carmen de Labra, Ana Maseda, Trinidad Lorenzo, Helena Agrafojo, José Luis Rodríguez-Villamil, Isabel González-Abraldes, José C Millán-Calenti
Prevalence of neuropsychiatric symptoms (NPS) and correlation between its intensity and caregiver distress were evaluated as a function of the care-setting in a cross-sectional study including 72 patient-caregiver dyads. The Neuropsychiatric Inventory and the Caregiver Distress Scale were administered. The most prevalent symptoms were: in the formal care-setting, agitation/aggression and depression/dysphoria (42.4%), and in the informal care-setting, aberrant motor behavior (59.0%). While changes in appetite and eating behaviors, depression/dysphoria and irritability/lability were more prevalent in the formal care-setting (p < ...
September 9, 2016: Geriatric Nursing
https://www.readbyqxmd.com/read/27617414/identifying-a-system-of-predominant-negative-symptoms-network-analysis-of-three-randomized-clinical-trials
#20
Stephen Z Levine, Stefan Leucht
BACKGROUND: Reasons for the recent mixed success of research into negative symptoms may be informed by conceptualizing negative symptoms as a system that is identifiable from network analysis. We aimed to identify: (I) negative symptom systems; (I) central negative symptoms within each system; and (III) differences between the systems, based on network analysis of negative symptoms for baseline, endpoint and change. METHODS: Patients with chronic schizophrenia and predominant negative symptoms participated in three clinical trials that compared placebo and amisulpride to 60days (n=487)...
December 2016: Schizophrenia Research
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