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https://www.readbyqxmd.com/read/30427894/motivation-to-participate-in-high-intensity-functional-exercise-compared-with-a-social-activity-in-older-people-with-dementia-in-nursing-homes
#1
Anna Sondell, Erik Rosendahl, Johan Nilsson Sommar, Håkan Littbrand, Lillemor Lundin-Olsson, Nina Lindelöf
BACKGROUND: Motivation to participate in exercise among people with dementia has not been well studied. The symptoms of dementia, including apathy, may lead to low motivation to participate in exercise. The aim of this study was to evaluate the motivation of older people with dementia to participate in a high-intensity exercise program compared with motivation of those participating in a social group activity. METHODS: The Umeå Dementia and Exercise Study (UMDEX) was a cluster-randomized controlled intervention trial including 186 people (mean age; 85, 75% female) with dementia in nursing homes...
2018: PloS One
https://www.readbyqxmd.com/read/30425751/apathy-is-correlated-with-widespread-diffusion-tensor-imaging-dti-impairment-in-amyotrophic-lateral-sclerosis
#2
Cinzia Femiano, Francesca Trojsi, Giuseppina Caiazzo, Mattia Siciliano, Carla Passaniti, Antonio Russo, Alvino Bisecco, Mario Cirillo, Maria Rosaria Monsurrò, Fabrizio Esposito, Gioacchino Tedeschi, Gabriella Santangelo
Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/30423541/effect-of-istradefylline-on-mood-disorders-in-parkinson-s-disease
#3
Hiroshi Nagayama, Osamu Kano, Hidetomo Murakami, Kenjiro Ono, Masashi Hamada, Tatsushi Toda, Renpei Sengoku, Yasushi Shimo, Nobutaka Hattori
Depression is the most common psychiatric complication in patients with Parkinson's disease (PD). Istradefylline, a new anti-parkinsonian agent with completely different mechanism, improves depression-like symptoms in an experimental disease model; however, there is no report of its effects in PD patients. In this study, the effectiveness of istradefylline for treatment of mood disorders in patients with PD was examined in an open-label trial. Thirty PD patients were enrolled. All patients had scores of higher than cut-off level in at least one of the following batteries: Snaith-Hamilton Pleasure Scale Japanese version (SHAPS-J), Apathy scale, or Beck Depression Inventory-2nd edition (BDI)...
November 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30408646/gender-and-onset-age-related-differences-of-non-motor-symptoms-and-quality-of-life-in-drug-na%C3%A3-ve-parkinson-s-disease
#4
Tao Hu, Ruwei Ou, Hui Liu, Yanbing Hou, Qianqian Wei, Wei Song, Bei Cao, Yongping Chen, Xiaoqin Yuan, Huifang Shang
OBJECTIVE: This study aims to explore the gender and onset age-related differences of non-motor symptoms (NMS) and the determinants of quality of life (QoL) in a large cohort of Chinese drug-naïve Parkinson's disease (PD) patients. PATIENTS AND METHODS: A cross-sectional analysis of 569 drug-naïve PD patients was conducted. The frequency and severity of each NMS was evaluated by Non-Motor Symptom Scale (NMSS), which consists of 9 subdomains. PD Questionnaire-39 (PDQ-39) was used to assess the QoL of PD patients...
November 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30406574/apathy-and-health-related-quality-of-life-in-nursing-home-residents
#5
Johanna M H Nijsten, Ruslan Leontjevas, Martin Smalbrugge, Raymond T C M Koopmans, Debby L Gerritsen
PURPOSE: To explore the association between apathy and health-related quality of life (HRQoL) from resident and proxy perspectives and whether cognition and depression moderate this relationship. METHODS: Secondary analyses with baseline data from a cluster randomized trial on the effects of a care program for depression in Nursing Homes (NHs) were conducted. For HRQoL, the Visual Analogue Scale (VAS) and the Dutch version of the European Quality of Life (EQ-5D) were administered to 521 NH residents, and to professional caregivers reporting from the perspective of the NH resident (Resident-Proxy) and from their own perspective (Proxy-Proxy)...
November 7, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/30400094/psychometric-properties-of-apathy-scales-in-dementia-a-systematic-review
#6
Dana Mohammad, Courtney Ellis, Allison Rau, Paul B Rosenberg, Jacobo Mintzer, Myuri Ruthirakuhan, Nathan Herrmann, Krista L Lanctôt
Apathy is a prevalent and problematic neuropsychiatric symptom in those with dementia that is emerging as a treatment target, necessitating accurate assessment. While many apathy scales are available, not all have been developed for use exclusively in dementia, and psychometric properties may vary across different populations. This systematic review aimed to provide an overview of the psychometric properties of apathy scales used in Alzheimer's disease (AD) and related dementias, as well as rate the methodological quality of supporting studies...
October 29, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/30376184/habitual-exercisers-versus-sedentary-subjects-with-parkinson-s-disease-multimodal-pet-and-fmri-study
#7
Matthew A Sacheli, Danielle K Murray, Nasim Vafai, Mariya V Cherkasova, Katie Dinelle, Elham Shahinfard, Nicole Neilson, Jessamyn McKenzie, Michael Schulzer, Silke Appel-Cresswell, Martin J McKeown, Vesna Sossi, A Jon Stoessl
BACKGROUND: The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. OBJECTIVE: To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. METHODS: Eight habitual exercisers and 9 sedentary subjects completed [11 C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum...
October 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30369270/the-burden-of-apathy-for-caregivers-of-patients-with-amyotrophic-lateral-sclerosis
#8
Jashelle Caga, Sharpley Hsieh, Elizabeth Highton-Williamson, Margaret C Zoing, Eleanor Ramsey, Emma Devenney, Rebekah M Ahmed, Anne Hogden, Matthew C Kiernan
OBJECTIVES: Apathy is the most common behavioral symptom of amyotrophic lateral sclerosis (ALS). Despite its known impact on caregiver wellbeing, apathy is typically considered a unitary construct making assessment and targeting treatment problematic. The aim of this study was to explore the relationship between caregiver burden and the behavioral, cognitive, and emotional symptoms of apathy in ALS. METHODS: Fifty-one ALS patient-caregiver dyads from an ALS/frontotemporal dementia Clinic were assessed with the Apathy Evaluation Scale which measured the cognitive, behavioral, emotional, and nonspecific symptoms of apathy as well as the Zarit Burden Interview, a measure of perceived burden among caregivers of cognitively impaired older adults...
October 29, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/30355543/emotional-feeling-in-patients-suffering-from-amyotrophic-lateral-sclerosis
#9
Johanna Unglik, Catherine Bungener, Daniel Delgadillo, François Salachas, Pierre François Pradat, Gaëlle Bruneteau, Timothée Lenglet, Nadine Le Forestier, Philippe Couratier, Yannick Vacher, Lucette Lacomblez
OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis...
October 23, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/30346438/-rate-of-progression-of-parkinson-s-disease-with-early-and-delayed-prescription-of-levodopa-preparations
#10
A V Rosinskaya, E E Vasenina, T N Khaybullin, O S Levin
AIM: To optimize therapy with levodopa preparations in relation to the rate of disease progression. MATERIAL AND METHODS: Eighty-six patients with Parkinson's disease (PD) were studied. Rate of progression was assessed by time of developing the 3rd stage of the disease. Patient state was assessed using MDS-UPDRS, MMSE, verbal activity test, clock drawing test, Beck depression scale, apathy scale and scale of autonomic disorders. RESULTS AND CONCLUSION: In 37 patients, early prescription of levodopa preparations (on average 1,7 years after disease onset) facilitates a decrease in the rate of progression assessed by time of developing the 3rd stage of the disease (7,3±4,4 vs 5,8±2,8 years)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30322899/cortical-correlates-of-behavioural-change-in-amyotrophic-lateral-sclerosis
#11
Monica Consonni, Stefano F Cappa, Eleonora Dalla Bella, Valeria Elisa Contarino, Giuseppe Lauria
BACKGROUND: Behavioural changes in amyotrophic lateral sclerosis (ALS) are heterogeneous. The study aim was to identify the behavioural profiles of non-demented patients with ALS and their neuroimaging correlates and to elucidate if they are comparable to those reported in studies of the behavioural-variant of frontotemporal dementia (bvFTD). METHODS: Behavioural changes of 102 non-demented patients with ALS were assessed through the Frontal Behavioural Inventory (FBI), a 24-item scale assessing different behavioural modifications, mainly chosen from the core clinical features of FTD...
October 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30279047/a-cross-sectional-study-in-cognitive-and-neurobehavioral-impairment-in-long-term-nasopharyngeal-cancer-survivors-treated-with-intensity-modulated-radiotherapy
#12
Lachlan J McDowell, Jolie Ringash, Wei Xu, Biu Chan, Lin Lu, John Waldron, Kathy Rock, Nathaniel So, Shao Hui Huang, Meredith Giuliani, Andrew Hope, Brian O'Sullivan, Scott V Bratman, John Cho, John Kim, Raymond Jang, Andrew Bayley, Lori J Bernstein
PURPOSE/OBJECTIVES: To determine neurocognitive and neurobehavioral impairment in long-term nasopharyngeal cancer survivors (NPC) treated with intensity-modulated radiotherapy (IMRT). MATERIALS/METHODS: A cross-sectional cohort of NPC ≥4 years (y) following IMRT was assessed. Objective cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and patient-reported memory was assessed with the MDASI-HN problems remembering item. Patient and family ratings of patients' neurobehavioral symptoms of apathy, disinhibition and executive dysfunction were assessed with the Frontal Systems Behavior Scale (FrSBe)...
September 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30277457/apathy-alters-emotional-arousal-in-chronic-schizophrenia
#13
Thibaut Dondaine, Pierre Philippot, Jean-Marie Batail, Florence Le Jeune, Md PhD Paul Sauleau, Sophie Drapier, Marc Vérin, Md PhD Bruno Millet, Dominique Drapier, Gabriel Robert
BACKGROUND: Within the heterogeneity of schizophrenia, apathy constitutes an independent cluster of negative symptoms associated with poor outcomes. Attempts to identify an emotional deficit in patients who have schizophrenia with negative symptoms have yielded mixed results, and studies that focus on the relationship between apathy and emotional disorders are lacking. METHODS: We set out to remedy this shortcoming using a validated battery of film excerpts to induce positive and negative emotions in patients with chronic schizophrenia with ( n = 20) or without ( n = 20) apathy, and in controls ( n = 20) comparable for age, sex and socioeconomic status...
October 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30264539/fatigue-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#14
Mattia Siciliano, Luigi Trojano, Gabriella Santangelo, Rosa De Micco, Gioacchino Tedeschi, Alessandro Tessitore
We conducted a systematic review and meta-analysis aimed at establishing robust prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles and abstracts, we selected 44 relevant studies (n = 7427 patients). Overall, the meta-analysis showed a prevalence of fatigue of 50% in PD. This prevalence estimate, however, was significantly moderated by study heterogeneity in measurement scales and cut-off thresholds. In contrast, demographic features, disease severity, cognitive impairment, and depression did not moderate prevalence estimates...
September 28, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30251374/does-the-geriatric-depression-scale-measure-depression-in-parkinson-s-disease
#15
Francesca V Lopez, Molly Split, J Vincent Filoteo, Irene Litvan, Raeanne C Moore, Eva Pirogovsky-Turk, Lin Liu, Stephanie Lessig, Dawn M Schiehser
The Geriatric Depression Scale (GDS) is recommended for screening depression in individuals with Parkinson's disease (PD). Empirical evidence, however, is limited regarding its validity and factor structure in PD. Thus, the current study sought to evaluate the convergent and divergent validity of the GDS, as well as the structure and validity of the derived factors. METHOD: Nondemented individuals with PD (n = 158) completed the GDS-30, and items were subjected to a principle component analysis...
September 25, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/30246686/cerebral-blood-flow-in-striatal-regions-is-associated-with-apathy-in-patients-with-schizophrenia
#16
Karoline Schneider, Lars Michels, Matthias N Hartmann-Riemer, Achim Burrer, Philippe N Tobler, Philipp Stämpfli, Matthias Kirschner, Erich Seifritz, Stefan Kaiser
BACKGROUND: Striatal dysfunction has been proposed as a pathomechanism for negative symptoms in schizophrenia. There is consensus that negative symptoms can be grouped into 2 dimensions: apathy and diminished expression. Recent studies suggest that different neural mechanisms underlie these dimensions, but the relationship between regional resting-state cerebral blood flow (rCBF) and negative symptom dimensions has not been investigated. METHODS: This study included 29 patients with schizophrenia and 20 healthy controls...
September 7, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30238286/-the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#17
Alain D Dekker, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Gert Van Goethem, Christine Zu Eulenburg, Antonia M W Coppus, Peter P De Deyn
Behavioral and psychological symptoms of dementia (BPSD) have not been comprehensively studied in people with Down syndrome, despite their high risk on dementia. A novel evaluation scale was developed to identify the nature, frequency and severity of behavioral changes (83 behavioral items in 12 clinically defined sections). Central aim was to identify items that change in relation to the dementia status. Structured interviews were conducted with informants of people with Down syndrome without dementia (DS, N = 149), with questionable dementia (DS + TD, N = 65) and with diagnosed dementia (DS + AD, N = 67)...
October 2018: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/30234601/structural-brain-changes-in-perinatally-hiv-infected-young-adolescents-in-south-africa
#18
Jacqueline Hoare, Jean-Paul Fouche, Nicole Phillips, John A Joska, Landon Myer, Heather J Zar, Dan J Stein
OBJECTIVE: To describe the structural brain changes, neurocognitive and mental health associations in adolescents perinatally infected with HIV-1 infection. DESIGN: Cross-sectional. METHODS: 204 adolescents with perinatally acquired HIV and 44 uninfected frequency matched controls aged 9 to 11 years were enrolled within the Cape Town Adolescent Antiretroviral Cohort. Diffusion tensor imaging and structural brain magnetic resonance imaging (MRI) was done to determine fractional anisotropy (FA), mean diffusivity (MD), gray and white matter volumes, cortical thickness and cortical surface area...
September 17, 2018: AIDS
https://www.readbyqxmd.com/read/30212839/apathy-in-rapid-eye-movement-sleep-behaviour-disorder-is-associated-with-serotonin-depletion-in-the-dorsal-raphe-nucleus
#19
Thomas R Barber, Ludovica Griffanti, Kinan Muhammed, Daniel S Drew, Kevin M Bradley, Daniel R McGowan, Marie Crabbe, Christine Lo, Clare E Mackay, Masud Husain, Michele T Hu, Johannes C Klein
Apathy is a common and under-recognized disorder that often emerges in the prodromal phase of Parkinsonian diseases. The mechanism by which this occurs is not known, but recent evidence from patients with established Parkinson's disease suggests that serotonergic dysfunction may play a role. The integrity of the raphe serotonergic system can be assessed alongside dopaminergic basal ganglia imaging using the radioligand 123I-ioflupane, which binds both serotonin and dopamine transporters. To investigate the relative roles of these neurotransmitters in prodromal parkinsonism, we imaged patients with idiopathic rapid eye movement sleep behaviour disorder, the majority of whom will develop a parkinsonian disorder in future...
October 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30211612/executive-impairment-is-associated-with-unawareness-of-neuropsychiatric-symptoms-in-premanifest-and-early-huntington-s-disease
#20
Sophie C Andrews, David Craufurd, Alexandra Durr, Blair R Leavitt, Raymund A Roos, Sarah J Tabrizi, Julie C Stout
OBJECTIVE: Unawareness of neuropsychiatric symptoms appears to be common in Huntington's disease (HD), but the clinical correlates of unawareness are unclear. Identifying predictors of unawareness is important for improving diagnosis of neuropsychiatric symptoms, and cognitive impairment, specifically executive impairment, may be a potential important predictor of unawareness. The authors examined whether unawareness of neuropsychiatric symptoms is more common in early HD compared to premanifest HD, and whether executive task performance was associated with awareness, independent of demographic, motor or mood variables...
September 13, 2018: Neuropsychology
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