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https://www.readbyqxmd.com/read/30009198/apathy-and-brain-alterations-in-parkinson-s-disease-a-multimodal-imaging-study
#1
Olaia Lucas-Jiménez, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, María Díez-Cirarda, Juan Carlos Gómez-Esteban, María Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
Objective: Apathy is a common nonmotor symptom in Parkinson's disease (PD) affecting 40% of patients. The aim of the study was to investigate brain changes and correlates of frontal, striatal, and limbic pathways related to subclinical symptoms of apathy in PD patients. Methods: Thirty-two PD patients divided into low-subclinical symptoms of apathy (LSA) ( n = 18) and high-subclinical symptoms of apathy (HSA) ( n = 14) and 25 healthy controls (HC) underwent a T1-weighted, diffusion-weighted, and resting-state functional MRI...
July 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29977428/effect-of-methylphenidate-for-apathy-on-visual-attention-scanning-behavior-a-pilot-study
#2
Sarah A Chau, Nathan Herrmann, Jonathan Chung, Moshe Eizenman, Krista L Lanctôt
Background: The purpose of this pilot study was to explore the potential of eye-tracking technology in monitoring symptoms and predicting outcomes in apathetic Alzheimer's disease (AD) patients treated with methylphenidate (MTP). Methods: Neuropsychological tests and eye-tracking measurements were completed at baseline and following at least four weeks of treatment with MTP (5-10 mg BID). Eye-movements were measured while patients viewed novel and social stimuli...
June 2018: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/29971569/self-and-informant-rated-apathy-in-patients-with-childhood-onset-craniopharyngioma
#3
Aylin Mehren, Jale Özyurt, Paula Zu Klampen, Svenja Boekhoff, Christiane M Thiel, Hermann L Müller
INTRODUCTION: The current study aimed to assess whether childhood-onset craniopharyngioma patients suffer from symptoms of apathy, as assessed by patients themselves and their close others. We further analyzed whether apathy scores are related to symptoms of depression. METHODS: Childhood-onset craniopharyngioma patients (n = 35, 16 female, median age = 22) and matched healthy controls (n = 35, 19 female, median age = 21) were asked to complete self-ratings of the Apathy Evaluation Scale, whereas informant-ratings were obtained from their close others...
July 3, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29953925/disrupted-amplitude-of-low-frequency-fluctuations-and-causal-connectivity-in-parkinson-s-disease-with-apathy
#4
Yu-Ting Shen, Jun-Yi Li, Yong-Sheng Yuan, Xi-Xi Wang, Min Wang, Jian-Wei Wang, Hui Zhang, Lin Zhu, Ke-Zhong Zhang
Apathy is a common non-motor symptom in Parkinson's disease (PD). We aimed to explore its associated neural substrates changes via amplitude of low-frequency fluctuations (ALFF) and granger causality analysis (GCA). Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed in 20 PD patients with apathy (PD-A), 22 PD patients without apathy (PD-NA) and 19 healthy volunteers. GCA, a new method exploring direction from one brain region to another, was based on brain regions showing alterations of neural activity as seeds, which were examined utilizing ALFF approach...
June 25, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29951186/apathy-following-bilateral-deep-brain-stimulation-of-subthalamic-nucleus-in-parkinson-s-disease-a-meta-analysis
#5
REVIEW
Ying Wang, Yongsheng Li, Xiaona Zhang, Anmu Xie
Bilateral deep brain stimulation of subthalamic nucleus (STN-DBS) has proven effective in improving motor symptoms in Parkinson's disease (PD) patients. However, psychiatric changes after surgery are controversial. In this study, we specifically analyzed apathy following bilateral STN-DBS in PD patients using a meta-analysis. Relevant articles utilized for this study were obtained through literature search on PubMed, ScienceDirect, and Embase databases. The articles included were those contained both pre- and postsurgery apathy data acquired using the Starkstein Apathy Scale or Apathy Evaluation Scale with patient follow-up of at least three months...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29948250/the-cognitive-affective-motivational-and-clinical-longitudinal-determinants-of-apathy-in-schizophrenia
#6
Stéphane Raffard, Catherine Bortolon, Hanan Yazbek, Christophe Lançon, Michel Benoit, Joanna Norton, Delphine Capdevielle
Apathy is a frequent and debilitating condition with few treatment options available in schizophrenia patients. Despite evidence of its multidimensional structure, most of past studies have explored apathy through a categorical approach. The main objective of this study was to identify the cognitive, emotional, motivational, and clinical factors at baseline that best predicted the three subtypes of apathy dimensions at follow-up. In a longitudinal study, 137 participants diagnosed with schizophrenia underwent different assessments including clinical, motivational, affective and cognitive measurements, at 1-month (referred to as baseline) and 12-month follow-ups...
June 8, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29935757/personality-traits-and-course-of-symptoms-of-depression-and-apathy-after-stroke-results-of-the-casper-study
#7
Elles Douven, Julie Staals, Syenna H J Schievink, Robert J van Oostenbrugge, Frans R J Verhey, Sascha Wetzels-Meertens, Sebastian Köhler, Pauline Aalten
OBJECTIVE: Post-stroke depression (PSD) and post-stroke apathy (PSA) are both associated with adverse outcome after stroke. This study aimed to examine whether personality traits predict the course of PSD and PSA. METHODS: In this prospective cohort study, 240 stroke patients completed the NEO Five Factor Inventory, Montgomery-Åsberg Depression Rating Scale, and Apathy Evaluation Scale at 3 months post-stroke. Neuropsychiatric assessment was repeated at 6- and 12-month follow-up after initial testing...
August 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29934845/executive-dysfunctions-differentially-predict-amotivation-in-first-episode-schizophrenia-spectrum-disorder-a-prospective-1-year-follow-up-study
#8
Wing Chung Chang, Jasmine Tsz Ting Liu, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Yi Nam Suen, Eric Yu Hai Chen
Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18-55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively...
June 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29912880/investigating-the-association-of-ventral-and-dorsal-striatal-dysfunction-during-reward-anticipation-with-negative-symptoms-in-patients-with-schizophrenia-and-healthy-individuals
#9
Marta Stepien, Andrei Manoliu, Roman Kubli, Karoline Schneider, Philippe N Tobler, Erich Seifritz, Marcus Herdener, Stefan Kaiser, Matthias Kirschner
BACKGROUND: Negative symptoms are a core feature of schizophrenia and also found in healthy individuals in subclinical forms. According to the current literature the two negative symptom domains, apathy and diminished expression may have different underlying neural mechanisms. Previous observations suggest that striatal dysfunction is associated with apathy in schizophrenia. However, it is unclear whether apathy is specifically related to ventral or dorsal striatal alterations. Here, we investigated striatal dysfunction during reward anticipation in patients with schizophrenia and a non-clinical population, to determine whether it is associated with apathy...
2018: PloS One
https://www.readbyqxmd.com/read/29906681/reliability-and-validity-of-the-self-report-version-of-the-apathy-evaluation-scale-in-first-episode-psychosis-concordance-with-the-clinical-version-at-baseline-and-12-months-follow-up
#10
Ann Faerden, Siv Hege Lyngstad, Carmen Simonsen, Petter Andreas Ringen, Oleg Papsuev, Ingrid Dieset, Ole A Andreassen, Ingrid Agartz, Stephen R Marder, Ingrid Melle
Negative symptoms have traditionally been assessed based on clinicians' observations. The subjective experience of negative symptoms in people with psychosis may bring new insight. The Apathy Evaluation Scale (AES) is commonly used to study apathy in psychosis and has corresponding self-rated (AES-S) and clinician-rated (AES-C) versions. The aim of the present study was to determine the validity and reliability of the AES-S by investigating its concordance with the AES-C. Eighty-four first-episode (FEP) patients completed the shortened 12-item AES-S and AES-C at baseline (T1) and 12 months (T2)...
May 31, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29884723/tau-induced-focal-neurotoxicity-and-network-disruption-related-to-apathy-in-alzheimer-s-disease
#11
Soichiro Kitamura, Hitoshi Shimada, Fumitoshi Niwa, Hironobu Endo, Hitoshi Shinotoh, Keisuke Takahata, Manabu Kubota, Yuhei Takado, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi
OBJECTIVE: Apathy is a common neuropsychological symptom in Alzheimer's disease (AD), and previous studies demonstrated that neuronal loss and network disruption in some brain regions play pivotal roles in the pathogenesis of apathy. However, contributions of tau and amyloid-β (Aβ) depositions, pathological hallmarks of AD, to the manifestation of apathy remain elusive. METHODS: Seventeen patients with AD underwent positron emission tomography (PET) with 11 C-pyridinyl-butadienyl-benzothiazole 3 (11 C-PBB3) and 11 C-Pittsburgh compound-B (11 C-PiB) to estimate tau and Aβ accumulations using standardised uptake value ratio (SUVR) images...
June 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29879608/factor-structure-of-the-geriatric-depression-scale-and-measurement-invariance-across-gender-among-chinese-elders
#12
Jiayue He, Xue Zhong, Shuqiao Yao
BACKGROUND: The Geriatric Depression Scale (GDS) is commonly used in research and clinical settings for screening of depression. The current study aimed to examine the best-fit factor structure model of the GDS among Chinese elders and to evaluate the measurement invariance of the GDS across genders. METHODS: Participants included 1,553 elderly residents from the Hunan, Shandong, and Beijing provinces. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted in tandem to determine the structure of the GDS on a large scale...
May 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29865086/participation-and-the-role-of-neuropsychological-functioning-in-myotonic-dystrophy-type-1
#13
Caroline Van Heugten, Susan Meuleman, Danique Hellebrekers, Esther Kruitwagen-van Reenen, Johanna Visser-Meily
BACKGROUND: Myotonic Dystrophy type 1 (DM1) is primarily a neuromuscular disease but can also have neuropsychological consequences (i.e.cognitive, emotional and behavioural) which can influence daily living and societal participation. Not much is known about the level of participation of DM1 patients and their relatives and the factors influencing participation. This information can guide the development of rehabilitation programs and identify those at risk of long-term participation problems...
2018: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29851173/the-course-of-apathy-in-late-life-depression-treated-with-electroconvulsive-therapy-a-prospective-cohort-study
#14
A Carlier, E van Exel, A Dols, F Bouckaert, P Sienaert, M Ten Kate, M P Wattjes, M Vandenbulcke, M L Stek, D Rhebergen
OBJECTIVES: Apathy, a lack of motivation, is frequently seen in older individuals, with and without depression, with substantial impact on quality of life. This prospective cohort study of patients with severe late-life depression treated with electroconvulsive therapy (ECT) aims to study the course of apathy and the predictive value of vascular burden and in particular white matter hyperintensities on apathy course. METHODS: Information on apathy (defined by a score of >13 on the Apathy Scale), depression severity, vascular burden, and other putative confounders was collected in at 2 psychiatric hospitals on patients with late-life depression (aged 55 to 87 years, N = 73)...
May 30, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29843585/huntington-s-disease-gene-expansion-carriers-are-aware-of-their-degree-of-apathy
#15
Verena Baake, Erik van Duijn, Raymund A C Roos
Huntington's disease is characterized by motor and behavioral symptoms as well as cognitive decline. Apathy is a common behavioral symptom, and its severity is related to disease progression. It has been suggested that Huntington's disease gene expansion carriers (HDGECs) are unaware of the signs and symptoms of the disease, which may account for their own level of awareness of their apathy. Therefore, the authors investigated the level of agreement on the degree of apathy severity between HDGECs and their proxies by using a self-report questionnaire...
May 30, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29804147/correlation-among-olfactory-function-motors-symptoms-cognitive-impairment-apathy-and-fatigue-in-patients-with-parkinson-s-disease
#16
Carla Masala, Paolo Solla, A Liscia, G Defazio, L Saba, A Cannas, A Cavazzana, T Hummel, A Haehner
Although Parkinson's disease (PD) is usually considered as a movement disorder, it is strongly associated with non-motor symptoms (NMS), including smell and taste dysfunctions, cognitive impairment, apathy, fatigue, and autonomic dysregulation. Olfactory deficit is considered the most common NMS in PD preceding the motor symptoms for years. The aim of this study was to investigate olfactory function, cognitive impairment, apathy, and fatigue in patients with PD in comparison with healthy controls, and subsequently to analyse the correlations between these NMS and motor symptoms severity in subjects with PD...
May 26, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29801896/reduced-gray-matter-volume-is-correlated-with-frontal-cognitive-and-behavioral-impairments-in-parkinson-s-disease
#17
Tatsuhiro Terada, Jun Miyata, Tomokazu Obi, Manabu Kubota, Miho Yoshizumi, Toshiya Murai
OBJECTIVE: To identify the brain-volume reductions associated with frontal cognitive and behavioral impairments in Parkinson's disease (PD). METHODS: Forty PD patients without dementia or amnesia (Hoehn and Yahr stage 3) and 10 age-matched controls underwent brain magnetic resonance imaging. Cognitive and behavioral impairments were assessed by using the Frontal Assessment Battery (FAB) and Frontal Systems Behavioral Scale (FrSBe), respectively. We applied voxel-based morphometry to investigate the correlations of regional gray matter volume with FAB, FrSBe, and physical disability...
July 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29788381/the-role-of-apathy-and-depression-on-verbal-learning-and-memory-performance-after-stroke
#18
Keera N Fishman, Andrea R Ashbaugh, Krista L Lanctôt, Megan L Cayley, Nathan Herrmann, Brian J Murray, Michelle Sicard, Karen Lien, Demetrios J Sahlas, Richard H Swartz
Objective: Psychiatric symptoms, including depression and apathy, may significantly impede functional and cognitive capabilities following a cerebrovascular event. This study examined the role of apathy and depression on learning and memory performance in stroke patients. Method: Stroke patients (n = 140 [119 ischemic, 21 hemorrhagic], mean age = 60.6 [SD = 15.1]) completed the Apathy Evaluation Scale (AES), the Center for Epidemiologic Studies Depression Scale (CES-D), and the California Verbal Learning Test-Second Edition (CVLT-II)...
May 18, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29787739/apathy-in-individuals-with-parkinson-s-disease-associated-with-mild-cognitive-impairment-a-neuropsychological-investigation
#19
Alberto Costa, Antonella Peppe, Silvia Zabberoni, Francesco Scalici, Carlo Caltagirone, Giovanni Augusto Carlesimo
Apathy is frequently reported in individuals with Parkinson's disease (PD) and is hypothesized to be associated with frontal-striatal related cognitive functions. Available data, however, do not provide univocal results. Moreover, this relationship has been poorly investigated in PD patients with mild cognitive impairment (MCI). This study was aimed at investigating the association between severity of apathy of PD patients and their performance on neuropsychological tests investigating executive abilities. Individuals with PD (i...
May 19, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29734988/change-in-cognition-and-other-non-motor-symptoms-with-obstructive-sleep-apnea-treatment-in-parkinson-disease
#20
Marta Kaminska, Victoria P Mery, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, Priti Gros, R John Kimoff
STUDY OBJECTIVES: Parkinson disease (PD) non-motor symptoms are associated with sleep disorders and impair quality of life. Our objective was to assess the effect of obstructive sleep apnea (OSA) treatment using continuous positive airway pressure (CPAP) on PD non-motor symptoms. METHODS: In this prospective observational study, 67 patients with idiopathic PD underwent polysomnography. Those with moderate-severe OSA were offered CPAP therapy. Subjects were divided into those without OSA (OSA-), and those with OSA (OSA+)...
May 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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