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https://www.readbyqxmd.com/read/29908287/characterization-of-nanomedicines-surface-coverage-using-molecular-probes-and-capillary-electrophoresis
#1
J-B Coty, F Varenne, A Benmalek, O Garsaa, I Le Potier, M Taverna, C Smadja, C Vauthier
A faithful characterization of nanomedicine (NM) is needed for a better understanding of their in vivo outcomes. Size and surface charge are studied with well-established methods. However, other relevant parameters for the understanding of NM behavior in vivo remain largely inaccessible. For instance, the reactive surface of nanomedicines, which are often grafted with macromolecules to decrease their recognition by the immune system, is excluded from a systematic characterization. Yet, it is known that a subtle modification of NM's surface characteristics (grafting density, molecular architecture and conformation of macromolecules) is at the root of major changes in the presence of biological components...
June 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29894984/using-repeated-ratings-to-improve-measurement-precision-in-incomplete-rating-designs
#2
Eli Jones, Stefanie A Wind
When selecting a design for rater-mediated assessments, one important consideration is the number of raters who rate each examinee. In balancing costs and rater-coverage, rating designs are often implemented wherein only a portion of the examinees are rated by each judge, resulting in large amounts of missing data. One drawback to these sparse rating designs is the reduced precision of examinee ability estimates they provide. When increasing the number of raters per examinee is not feasible, another option may be to increase the number of ratings provided by each rater per examinee...
2018: Journal of Applied Measurement
https://www.readbyqxmd.com/read/29889911/the-laterally-closed-tunnel-for-the-treatment-of-deep-isolated-mandibular-recessions-surgical-technique-and-a-report-of-24-cases
#3
Anton Sculean, Edward P Allen
Predictable coverage of deep isolated mandibular gingival recessions is one of the most challenging endeavors in plastic-esthetic periodontal surgery, and limited data is available in the literature. The aim of this paper is to present the rationale, the step-by-step procedure, and the results obtained in a series of 24 patients treated by means of a novel surgical technique (the laterally closed tunnel [LCT]) specifically designed for deep isolated mandibular recessions. A total of 24 healthy patients (21 women and 3 men, mean age 25...
July 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29881832/tuberosity-versus-palatal-donor-sites-for-soft-tissue-grafting-a-split-mouth-clinical-study
#4
Peter N Amin, Nabil F Bissada, Paul A Ricchetti, Andre Paes B Silva, Catherine A Demko
OBJECTIVE: To compare postoperative pain associated with palatal and tuberosity donor sites for soft tissue grafting, and to evaluate the outcomes in both the donor and recipient sites. METHOD AND MATERIALS: Twenty healthy nonsmokers requiring bilateral soft tissue grafts were recruited for the study. For the 10 patients who required free gingival graft (FGG), 10 epithelialized grafts were taken from the tuberosity and 10 from the palate. The other 10 patients who required coronally advanced flap (CAF) and connective tissue graft (CTG) received 10 de-epithelialized grafts from the tuberosity and 10 from the palate...
2018: Quintessence International
https://www.readbyqxmd.com/read/29875559/comparative-evaluation-of-coronally-advanced-flap-using-amniotic-membrane-and-platelet-rich-fibrin-membrane-in-gingival-recession-an-18-month-clinical-study
#5
Mohd Rehan, Manish Khatri, Mansi Bansal, Komal Puri, Ashish Kumar
Background: An amnion membrane is a placenta-derived tissue that consists of numerous growth factors, proteins, and stem cell reserves which help in accelerated wound healing and regeneration. Platelet-rich fibrin (PRF) also releases growth factors after activation from the platelets and gets trapped within fibrin matrix which has been shown to stimulate the mitogenic response in the periosteum for bone repair and regeneration during normal wound healing. This preliminary, controlled, randomized clinical trial with an 18-month follow-up was aimed to evaluate the effectiveness of coronally advanced flap (CAF) with either PRF membrane or bioresorbable amniotic membrane (AM) in treatment of localized gingival recession defects...
April 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29873085/long-term-evaluation-20-years-of-the-outcomes-of-subepithelial-connective-tissue-graft-plus-coronally-advanced-flap-in-the-treatment-of-maxillary-single-recession-type-defects
#6
Giovan Paolo Pini Prato, Debora Franceschi, P Paolo Cortellini, Leandro Chambrone
BACKGROUND: Subepithelial connective tissue graft with coronally advanced flap (SCTG + CAF) has been considered the best and most predictable root coverage procedure. Thus, the aims of this study are twofold: 1) to evaluate the long-term outcomes following SCTG + CAF in the treatment of gingival recessions (GR) and 2) to explore the influence of several tooth/patient related factors on the stability of gingival margin at 1 year and 5,10,15,20 years after surgery. METHODS: 45 patients with 45 maxillary GR (Miller`s Class I or III) were treated with SCTG + CAF in a private practice between 1990 and 1997...
June 6, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29865215/realistic-indoor-radio-propagation-for-sub-ghz-communication
#7
Ben Bellekens, Rudi Penne, Maarten Weyn
This research article proposes a novel ray-launching propagation loss model that is able to use an environment model that contains the real geometry. This environment model is made by applying a Simultaneous Localization and Mapping (SLAM) algorithm. As a solution to the rising demands of Internet of Things applications for indoor environments, this deterministic radio propagation loss model is able to simulate an accurate coverage map that can be used for localization applications or network optimizations...
June 1, 2018: Sensors
https://www.readbyqxmd.com/read/29863949/epistemic-divides-and-ontological-confusions-the-psychology-of-vaccine-scepticism
#8
Matthew Browne
Vaccine scepticism is an increasingly important barrier to optimal coverage in developed countries. In this commentary, we make the case that negative attitudes towards vaccines reflect a broader and deeper set of beliefs about health and wellbeing. We suggest that this alternative worldview is influenced by ontological confusions (e.g. regarding purity, natural energy), and knowledge based on personal lived experience and trusted peers, rather than the positivist epistemological framework. Our view is supported by recent social-psychological research, including strong correlations of vaccine scepticism with adherence to complementary and alternative medicine, magical health beliefs, and conspiracy ideation...
June 4, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29849966/coronally-advanced-flap-and-connective-tissue-graft-with-or-without-plasma-rich-in-growth-factors-prgf-in-treatment-of-gingival-recession
#9
Niloofar Jenabian, Mina Motallebnejad, Ehsan Zahedi, Nima D Sarmast, Nikola Angelov
Background: Several researchers have tried to improve the results of gingival recession treatment techniques. One of the methods is to use growth factors The present study was undertaken to evaluate the effect of CAF (coronally advanced flap) + CTG (connective tissue graft) + PRGF (plasma rich in growth factors) in the treatment of Miller Class I buccal gingival recession. Material and Methods: Twenty-two teeth with Miller Class I gingival recession in 6 patients 26 ‒ 47 years of age were included in a split-mouth designed randomized controlled trial (RCT)...
May 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29797335/bayesian-methods-for-analysis-of-biosimilar-phase-iii-trials
#10
Robert E Weiss, Xiaomao Xia, Nan Zhang, Hui Wang, Eric Chi
A biologic is a product made from living organisms. A biosimilar is a new version of an already approved branded biologic. Regulatory guidelines recommend a totality-of-the-evidence approach with stepwise development for a new biosimilar. Initial steps for biosimilar development are (a) analytical comparisons to establish similarity in structure and function followed by (b) potential animal studies and a human pharmacokinetics/pharmacodynamics equivalence study. The last step is a phase III clinical trial to confirm similar efficacy, safety, and immunogenicity between the biosimilar and the biologic...
May 23, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29794259/a-proteomics-analysis-of-adventitious-root-formation-after-leaf-removal-in-lotus-nelumbo-nucifera-gaertn
#11
Cheng Libao, Liu Huiying, Jiang Runzhi, Li Shuyan
The formation of adventitious roots (ARs) is an important process for lotus (Nelumbo nucifera), which does not have a well-formed main root. In lotus, the removal of leaves above the waterline significantly promoted AR formation, while the removal of leaves below the waterline inhibited AR formation. Proteins were identified using isobaric tags for relative and absolute quantization technique. The number of proteins decreased with increasing sequencing coverage, and most of the identified proteins had fewer than 10 peptides...
May 25, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29786880/metagenomic-study-of-bacterial-microbiota-in-persistent-endodontic-infections-using-next-generation-sequencing
#12
G Sánchez-Sanhueza, H Bello-Toledo, G González-Rocha, A T Gonçalves, V Valenzuela, C Gallardo-Escárate
AIM: To determine the bacterial microbiota in root canals associated with persistent apical periodontitis and their relationship with the clinical characteristics of patients using next-generation sequencing (NGS). METHODOLOGY: Bacterial samples from root canals associated with teeth having persistent apical periodontitis were taken from 24 patients undergoing root canal retreatment. Bacterial DNA was extracted, and V3-V4 variable regions of the 16S rRNA gene were amplified...
May 22, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29779269/-the-applications-of-periodontal-gingival-surgery-%C3%A2-alternative-materials
#13
Er-Jia Mao
The main purposes of periodontal graft surgery include achieving root coverage, improving the clinical attachment level and keratinized tissue, and advancing the procedure of periodontal plastic surgery. Autogenous graft, such as subepithelial connective tissue graft-based procedure, provide the best outcomes for mean and complete root coverage, as well as increase in keratinized tissue. However, a disadvantage of the procedure is in the location of the operation itself: the additional surgical site (palate)...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29777669/repair-of-thoracic-and-thoracoabdominal-mycotic-aneurysms-and-infected-aortic-grafts-using-allograft
#14
Joel S Corvera, David Blitzer, Hannah Copeland, Daniel Murphy, Philip J Hess, Saila T Pillai, John W Fehrenbacher
BACKGROUND: Mycotic aneurysm of the thoracic or thoracoabdominal aorta and infection of thoracic or thoracoabdominal aortic grafts are challenging problems with high mortality. In-situ reconstruction with cryopreserved allograft(CPA) avoids placement of prosthetic material in an infected field and avoids suppressive antibiotics or autologous tissue coverage. METHODS: Fifty consecutive patients with infection of a thoracic or thoracoabdominal aortic graft or mycotic aneurysm underwent resection and replacement with CPA from 2006 to 2016...
May 16, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29777632/predictor-factors-for-long-term-outcomes-stability-of-coronally-advanced-flap-with-or-without-connective-tissue-graft-in-the-treatment-of-single-maxillary-gingival-recessions-9-years-results-of-a-randomised-controlled-clinical-trial
#15
Giulio Rasperini, Raffaele Acunzo, Gaia Pellegrini, Giorgio Pagni, Maurizio Tonetti, Giovan Paolo Pini Prato, Pierpaolo Cortellini
AIM: To assess the clinical outcomes 9 years after the surgical treatment of single maxillary gingival recessions and identify predictors for long-term gingival margin stability. MATERIALS AND METHODS: Twenty-five gingival recession (Miller Class I and II) were randomly treated with CAF plus CTG or CAF alone. Outcomes included Complete Root Coverage (CRC), Recession Reduction (REC), Keratinized Tissue (KT) gain and dentin hypersensitivity, and were evaluated at 6-month, 1-year and 9-year...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29772890/application-of-decision-tree-for-prediction-of-cutaneous-leishmaniasis-incidence-based-on-environmental-and-topographic-factors-in-isfahan-province-iran
#16
Roghieh Ramezankhani, Nooshin Sajjadi, Roya Nezakati Esmaeilzadeh, Seyed Ali Jozi, Mohammad Reza Shirzadi
Cutaneous Leishmaniasis (CL) is a neglected tropical disease that continues to be a health problem in Iran. Nearly 350 million people are thought to be at risk. We investigated the impact of the environmental factors on CL incidence during the period 2007- 2015 in a known endemic area for this disease in Isfahan Province, Iran. After collecting data with regard to the climatic, topographic, vegetation coverage and CL cases in the study area, a decision tree model was built using the classification and regression tree algorithm...
May 8, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29769776/root-coverage-with-buccal-fat-pad-placed-on-restored-cervical-abrasion-case-report-with-three-year-follow-up
#17
Harpreet Singh Grover, Sagrika Shukla, Ashi Chug, Kuldeep Singh
A patient was reported with Class II gingival recession (GR) of 5 mm. After restoring abrasion with glass ionomer cement, a full-thickness flap was raised and using blunt dissection through the buccinator and loose surrounding fascia buccal fat pad (BFP) was exposed into the mouth. It was easily spread over the maxillary roots of 14, 15, and 16. It was secured and immobilized using sutures. Postoperatively, the patient did not report swelling or trismus. At 3-year postoperative, gingival margin was at cementoenamel junction, stable and healthy and did not show any recession...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29769769/evaluation-of-periosteum-eversion-and-coronally-advanced-flap-techniques-in-the-treatment-of-isolated-miller-s-class-i-ii-gingival-recession-a-comparative-clinical-study
#18
Koel Debnath, Anirban Chatterjee
Aim: The present investigation aimed to evaluate root coverage (RC) with periosteum eversion technique (PET) using periosteum as a graft and coronally advanced flap (CAF) with platelet-rich fibrin (PRF) membrane as a graft in the treatment of isolated Miller's class I and II gingival recession defects. Materials and Methods: Thirty sites in 15 participants with Miller's Class I or II gingival recession were randomly treated either with PET using periosteum as graft and CAF + PRF as graft...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29768524/evaluation-of-the-effect-of-dose-dependent-platelet-rich-fibrin-membrane-on-treatment-of-gingival-recession-a-randomized-controlled-clinical-trial
#19
Rana Culhaoglu, Levent Taner, Berceste Guler
Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG). The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure. Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29761502/efficacy-of-tunnel-technique-in-the-treatment-of-localized-and-multiple-gingival-recessions-a-systematic-review-and-a-meta-analysis
#20
REVIEW
Lorenzo Tavelli, Shayan Barootchi, Trang V N Nguyen, Mustafa Tattan, Andrea Ravidà, Hom-Lay Wang
BACKGROUND: Tunnel technique (TUN) has recently gained popularity among clinicians for its promising clinical and esthetic results when treating gingival recessions (GRs) defects. However, the evidence of the efficacy of TUN in the literature is still to be determined. Therefore, the aim of the present systematic review and meta-analysis was to investigate the predictability of TUN and its comparison to coronally advanced flap (CAF) procedure. MATERIAL AND METHODS: A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until November 2017 was conducted to identify clinical studies investigating TUN for root coverage procedures...
May 14, 2018: Journal of Periodontology
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