Hemmings Wu, Sarah Adler, Dan E Azagury, Cara Bohon, Debra L Safer, Daniel A N Barbosa, Mahendra T Bhati, Nolan R Williams, Laura B Dunn, Peter A Tass, Brian D Knutson, Maya Yutsis, Ayesha Fraser, Tricia Cunningham, Kara Richardson, Tara L Skarpaas, Thomas K Tcheng, Martha J Morrell, Laura Weiss Roberts, Robert C Malenka, James D Lock, Casey H Halpern
BACKGROUND: Loss of control (LOC) is a pervasive feature of binge eating, which contributes significantly to the growing epidemic of obesity; approximately 80 million US adults are obese. Brain-responsive neurostimulation guided by the delta band was previously found to block binge-eating behavior in mice. Following novel preclinical work and a human case study demonstrating an association between the delta band and reward anticipation, the US Food and Drug Administration approved an Investigational Device Exemption for a first-in-human study...
November 16, 2020: Neurosurgery