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Narayanan Balaji, Suresh P Sulochana, Neeraj Kumar Saini, Siva Kumar A, Ramesh Mullangi
A simple, selective and reliable LC-MS/MS method was validated for simultaneous quantitation of darolutamide diastereomers in 50 μL mouse plasma using warfarin as an internal standard (IS) as per regulatory guidelines. Plasma samples were extracted by liquid-liquid extraction and the chromatographic separation was achieved on a Chiralpak IA column with an isocratic mobile phase 5 mm ammonium acetate-absolute alcohol (20:80, v/v) at a flow rate of 1.0 mL/min. Detection and quantitation was done in multiple reaction monitoring mode following the transitions m/z 397 → 202 and 307 → 250 for darolutamide diastereomers and the IS, respectively, in the negative ionization mode...
May 2018: Biomedical Chromatography: BMC
Cheng Suh-Chiou, Rosa M Moysés, Marcio S Bittencourt, Isabela M Bensenor, Paulo A Lotufo
BACKGROUND: Chronic kidney disease is a worldwide public health concern due to the increased prevalence the high fatalities related to heart disease in this population. Among novel cardiovascular risk markers, the coronary artery calcification score (CAC) emerged as an independent predictor of cardiovascular events. HYPOTHESIS: We aimed to test if glomerular filtration rate or albuminuria are independently associated with coronary calcification. METHODS: The Brazilian Longitudinal Study of Adult Health is a cohort of men and women aged 35 to 74 years old addressing cardiovascular diseases...
December 2017: Clinical Cardiology
Prapassorn Bussaman, Chirayu Sa-Uth, Angsumarn Chandrapatya, Remzi Atlihan, Ayhan Gökçe, Pavel Saska, Hsin Chi
Luciaphorus perniciosus Rack is one of the most serious pests of several cultivated mushroom species including Ganoderma lucidum (Fr.), Flammulina velutipes Karst., Auricularia polytricha (Mont.) Saac., Lentinus polychrous Lev., and Lentinus squarrosulus (Mont.) Singer in Thailand. Adult female Lu. perniciosus produce offspring inside their physogastric hysterosomas, with all embryos developing through to the adult stage while remaining in the abdomen. Once the abdomen ruptures, the female parent dies and the offspring consisting of mostly fertilized female adults along with a few male adults continue to emerge from the cadaver of the mother for a period of several days...
August 1, 2017: Journal of Economic Entomology
Daniel Noll, Brendan Mahon, Bhavna Shroff, Caroline Carrico, Steven J Lindauer
OBJECTIVE: To examine the orthodontic patient experience having braces compared with Invisalign by means of a large-scale Twitter sentiment analysis. MATERIALS AND METHODS: A custom data collection program was created that collected tweets containing the words "braces" or "Invisalign" for a period of 5 months. A hierarchal Naïve Bayes sentiment analysis classifier was developed to sort the tweets into five categories: positive, negative, neutral, advertisement, or not applicable...
May 2017: Angle Orthodontist
Sajid Aslam, Paul Khairy, Azadeh Shohoudi, Lise-Andrée Mercier, Annie Dore, François Marcotte, Joaquim Miró, Pablo Avila-Alonso, Réda Ibrahim, Anita Asgar, Nancy Poirier, François-Pierre Mongeon
BACKGROUND: Shone complex consists of a constellation of left-sided, usually obstructive, cardiac lesions, including supravalvar mitral ring, parachute mitral valve, subaortic stenosis, and aortic coarctation. Incomplete Shone complex consists of a mitral valve anomaly associated with lesions involving the subaortic region, aortic valve, or thoracic aorta. There is a paucity of data regarding long-term outcomes in adults with Shone complex. METHODS: We reviewed records of adults with complete or incomplete Shone complex followed at the Montreal Heart Institute between 1982 and 2014...
February 2017: Canadian Journal of Cardiology
Marija Meznaric, Erika Cvetko
Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). Diaphragmatic fibers were smaller than fibers in vastus lateralis with regard to the mean minimal fiber diameter of slow-twitch (46...
2016: BioMed Research International
R Gaillard, S Lustig, A Peltier, V Villa, E Servien, P Neyret
BACKGROUND: Despite excellent long-term outcomes, posterior stabilisation by a third condyle continues to receive unwarranted criticism regarding patellar complications and instability. HYPOTHESIS: Complication rates with a tri-condylar posterior-stabilised implant are similar to those with other posterior-stabilised prostheses and have diminished over time due to improvements in prosthesis design. MATERIAL AND METHODS: Post-operative complications and revision rates were assessed retrospectively in a prospective cohort of 4189 consecutive patients who had primary total knee arthroplasty (TKA) using a tri-condylar posterior-stabilised implant (Wright-Tornier) and were then followed-up for at least 24 months...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
A O Olanrewaju, A Robillard, M Dagher, D Juncker
We recently developed capillaric circuits (CCs) - advanced capillary microfluidic devices assembled from capillary fluidic elements in a modular manner similar to the design of electric circuits (Safavieh & Juncker, Lab Chip, 2013, 13, 4180-4189). CCs choreograph liquid delivery operations according to pre-programmed capillary pressure differences with minimal user intervention. CCs were thought to require high-precision micron-scale features manufactured by conventional photolithography, which is slow and expensive...
September 21, 2016: Lab on a Chip
Hongxu Zhang, Jianguang Zhong, Zhenyu Bian, Xiang Fang, You Peng, Yongping Hu
BACKGROUND: Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were not consistent. The objective of this study was to examine the role of these two gene polymorphisms in ARC susceptibility. METHODS: Eligible case-control studies published between January 2000 and 2015 were searched and retrieved in the electronic databases...
September 29, 2016: BMC Ophthalmology
I Kyvernitakis, K Kostev, T Nassour, F Thomasius, P Hadji
There has been concerning about women receiving depot medroxyprogesterone acetate (DMPA) contraception because of the prolonged hypoestrogenemic state regarding the potential negative effects on bone health. This study showed that DMPA exposure is associated with increased fracture risk and that fracture risk increases with longer DMPA exposure. INTRODUCTION: DMPA has been associated with impaired bone mineral acquisition during adolescence and accelerated bone loss in later life. We performed this large population-based study to assess the association between use of DMPA or combined oral contraceptives and the incident risk of fracture...
January 2017: Osteoporosis International
L Liu, T Meng, Q S Wang, H Z Jin, Z Q Sun, B Jin, F Fang, H J Wang
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in normal tissue was used as the basis for assessing tumors (control group). Real-time reverse transcription-polymerase chain reaction quantified miR-30a levels...
April 7, 2016: Genetics and Molecular Research: GMR
Mahdi Fakhar, Hossein Pazoki Ghohe, Sayed Abobakar Rasooli, Mehdi Karamian, Abdul Satar Mohib, Hajar Ziaei Hezarjaribi, Abdol Sattar Pagheh, Mohammad Amin Ghatee
Despite the high incidence of cutaneous leishmaniasis (CL) in Afghanistan, there is a little information concerning epidemiological status of the disease and phylogenetic relationship and population structure of causative agents. This study was conducted to determine the prevalence and distribution of CL cases and investigate the Leishmania tropica population structure in rural districts of Heart province in the West of Afghanistan in comparison to neighboring foci. Overall, 4189 clinically suspected CL cases from 177 villages (including 12 districts) in Herat province were enrolled in the referral laboratory of WHO sub-office in Herat city from January 2012 to December 2013...
July 2016: Infection, Genetics and Evolution
H Cassoudesalle, A Nozères, H Petit, V Cressot, F Muller, F Rouanet, I Sibon, P-A Joseph, P Dehail
OBJECTIVE: The main objective of this study was to describe the distribution of referrals offered to patients assessed in the "Post-Acute Stroke program" of Bordeaux University Hospital (France). This program was developed in 2008 to organize the dispensation of care in rehabilitation units specialized in neurological diseases. MATERIAL AND METHODS: This was a single-centre observational study. Between July 2008 and December 2012, data on the number of stroke patients hospitalized at the Bordeaux University Hospital and their post-acute referral were collected from the local hospital discharge database...
September 2016: Annals of Physical and Rehabilitation Medicine
Jinyan Luo, Wen Qiu, Lei Chen, Syed Ishtiaq Anjum, Menghao Yu, Changlin Shan, Mehmoona Ilyas, Bin Li, Yanli Wang, Guochang Sun
Biofilm formation is important for virulence of a large number of plant pathogenic bacteria. Indeed, some virulence genes have been found to be involved in the formation of biofilm in bacterial fruit blotch pathogen Acidovorax citrulli. However, some virulent strains of A. citrulli were unable to format biofilm, indicating the complexity between biofilm formation and virulence. In this study, virulence-related genes were identified in the biofilm-defective strain A1 of A. citrulli by using Tn5 insertion, pathogenicity test, and high-efficiency thermal asymmetric interlaced PCR (hiTAIL-PCR)...
2015: International Journal of Molecular Sciences
Tai-Ho Hung, Szu-Fu Chen, Jenn-Jeih Hsu, T'sang-T'ang Hsieh
OBJECTIVE: To investigate perinatal outcomes according to the 2009 Institute of Medicine (IOM) gestational weight gain (GWG) guidelines. MATERIALS AND METHODS: A retrospective cohort study was conducted among all term, singleton, live births to women who delivered at the Taipei Chang Gung Memorial Hospital, Taipei, Taiwan between 2009 and 2014. Women were categorized into three groups based on prepregnancy body mass index and GWG relative to the IOM guidelines. Multivariable logistic regression analysis was used to assess the associations between GWG outside the IOM guidelines and adverse perinatal outcomes...
August 2015: Taiwanese Journal of Obstetrics & Gynecology
M Azab, O F Khabour, K H Alzoubi, S A H Mahmoud, M Anabtawi, M Quttina
Waterpipe tobacco smoking is increasing in popularity, particularly among young adults. This popularity is related to the lack knowledge regarding the health effects of waterpipe smoking. In this study, we examined the genotoxicity of waterpipe smoking using an 8-hydroxy deoxyguanosine (8-OHdG) assay. Genotoxicity was evaluated in the saliva, urine, and serum of 66 waterpipe adult smokers and 46 healthy nonsmokers. The level of addiction to waterpipe smoking was evaluated using the Lebanon Waterpipe Dependence Scale-11...
2015: Genetics and Molecular Research: GMR
Zhuo Hao, Yang Gao, Jin-zhong Zhang, Ya-juan Xu, Gui-rui Yu
In this study, Qianyanzhou Xiangxi River Basin in the rainy season was monitored to measure different nitrogen form concentrations of rainfall and rainfall-runoff process, in order to explore the southern red soil region of nitrogen wet deposition characteristics and its influence on N output in watershed. The results showed that there were 27 times rainfall in the 2014 rainy season, wherein N wet deposition load reached 43.64-630.59 kg and N deposition flux were 0.44-6.43 kg · hm(-2), which presented a great seasonal variability...
May 2015: Huan Jing Ke Xue= Huanjing Kexue
Fahad Alajmi, Chaoshu Zeng, Dean R Jerry
Calanoid copepods are an important food source for most fish larvae. Their role as a natural prey item means that it is important to develop culture technology for copepods to meet the requirements of larvae culture in aquaculture hatcheries. Copepods have been cultured successfully for some time; however, the implications of long-term cultivation or domestication on copepod life history traits have not yet been assessed. Therefore, the aim of this study was to determine if the domesticated and wild populations of Parvocalanus crassirostris are phenotypically or physiologically different...
2015: PloS One
Wenpeng Huang, Yanbo Tang, Legen Nong, Yifan Sun
BACKGROUND AND AIMS: Postoperative intra-abdominal septic complications [IASCs] are the most feared risks of surgery for Crohn's disease[CD]. The risk factors for IASCs still remain controversial. The aim of this study was to assess the risk factors for IASCs in CD patients undergoing abdominal surgery. METHODS: MEDLINE, Cochrane Library, and EMBASE were searched to identify observational studies reporting the risk factors for IASCs in CD patients. A meta-analysis was conducted to investigate the impact of various risk factors on IASCs in CD...
March 2015: Journal of Crohn's & Colitis
Anna Gadaj, Kevin M Cooper, Nitsara Karoonuthaisiri, Ambrose Furey, Martin Danaher
The depletion of three banned nitroimidazole drugs - dimetridazole (DMZ), metronidazole (MNZ) and ronidazole (RNZ) - was investigated in black tiger shrimp (Penaeus monodon) following in-water medication. The highest concentrations of residues were measured immediately after the 24-h immersion (d0). At this time, MNZ and MNZ-OH residues were measured in shrimp tissue samples at concentrations ranging from 361 to 4189 and from 0.28 to 6.6 μg kg(-1), respectively. DMZ and its metabolites HMMNI ranged in concentration between 31,509 and 37,780 and between 15...
2015: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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