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https://www.readbyqxmd.com/read/28340553/promoting-independence-health-and-well-being-for-older-people-a-feasibility-study-of-computer-aided-health-and-social-risk-appraisal-system-in-primary-care
#1
Kate Walters, Kalpa Kharicha, Claire Goodman, Melanie Handley, Jill Manthorpe, Mima Cattan, Steve Morris, Caroline S Clarke, Jeff Round, Steve Iliffe
BACKGROUND: With population ageing, research is needed into new low-cost, scalable methods of effective promotion of health and wellbeing for older people. We aimed to assess feasibility, reach and costs of implementing a new tailored computer-aided health and social risk appraisal system in primary care. METHODS: Design: Feasibility study. SETTING: Five General Practices in London (Ealing) and Hertfordshire, United Kingdom (UK) Participants: Random sample of patients aged 65 + years...
March 24, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28340237/pain-and-cognition-in-multiple-sclerosis
#2
R Scherder, N Kant, E Wolf, A C M Pijnenburg, E Scherder
Objective. : The goal of the present study was to examine the relationship between pain and cognition in patients with multiple sclerosis. Design. : Cross-sectional. Setting. : Nursing home and personal environment of the investigators. Subjects. : Two groups of participants were included: 91 patients with multiple sclerosis and 80 matched control participants. Methods. : The level of pain was measured by the following pain scales: Number of Words Chosen-Affective, Colored Analogue Scale for pain intensity and suffering from pain, and the Faces Pain Scale...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340167/factors-influencing-cognitive-impairment-in-neuropathic-and-musculoskeletal-pain-and-fibromyalgia
#3
Begoña Ojeda, María Dueñas, Alejandro Salazar, Juan Antonio Mico, Luis Miguel Torres, Inmaculada Failde
Objective.:  To assess cognitive performance of chronic pain (CP) patients diagnosed with three types of pain-neuropathic pain (NP), musculoskeletal (MSK), and fibromyalgia (FM)-and to analyze the factors influencing cognitive difficulties in each group. Methods.:  Two hundred fifty-four CP patients-104 NP, 99 MSK, 51 FM-and 72 pain-free subjects were included in the study. The "Test Your Memory" (TYM) scale was used to assess cognitive performance. Pain intensity was measured by means of the visual analog scale (VAS); the Hospital Anxiety and Depression scale was used to assess mental status, and the Medical Outcome Study (MOS) sleep scale to assess sleep quality...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340064/the-influence-of-state-and-trait-anxiety-on-the-memory-of-pain
#4
Przemyslaw Babel
Objective. : The study aimed to assess the accuracy of memories of both pain and the state anxiety that accompanies experimentally induced pain and to investigate the factors that influence the memory of experimental pain. Methods. : Forty-nine healthy female volunteers participated in the study. The participants received three electrocutaneous pain stimuli during the first phase of the study and rated the pain intensity, pain unpleasantness, and state anxiety they felt at that moment...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339998/executive-functioning-in-pediatric-chronic-pain-do-deficits-exist
#5
Karen E Weiss, Cynthia Harbeck-Weber, Michael J Zaccariello, Jacqueline N Kimondo, Tracy E Harrison, Barbara K Bruce
Objective. : Despite ample research documenting deficits in executive functioning for adults with chronic pain, the literature on pediatric patients with chronic pain is limited and provides mixed results. The current study sought to further investigate the nature of executive dysfunction in this population and also examine the relationships between pain intensity, duration, and catastrophizing with sustained attention, working memory, and self- and parent-report of executive functioning...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339538/thalamic-amnesia-accompanying-disruption-of-pain-memory-a-case-of-right-anterior-thalamic-infarction-and-a-subsequent-vertebral-compression-fracture
#6
Naoki Asano, Shinichiro Maeshima, Sayaka Okamoto, Hideto Okazaki, Shigeru Sonoda
No abstract text is available yet for this article.
December 15, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28336100/in-vivo-evaluation-of-the-hippocampal-glutamate-gaba-and-the-bdnf-levels-associated-with-spatial-memory-performance-in-a-rodent-model-of-neuropathic-pain
#7
S Saffarpour, M Shaabani, N Naghdi, M Farahmandfar, A Janzadeh, F Nasirinezhad
BACKGROUND: Patients with chronic pain usually suffer from learning and memory impairment which may significantly decrease their quality of life. Despite laboratory and clinical studies, the mechanism underlying this memory impairment remains elusive. We evaluated the effect of chronic pain on the glutamate and GABA levels and BDNF expression in the CA1 region of hippocampus as a possible explanation for memory impairment related to neuropathic pain. METHODS: In this respect, 30 male rats were randomly allocated to 3 groups as control, sham and neuropathic...
March 20, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28321191/palmitoylethanolamide-reduces-neuropsychiatric-behaviors-by-restoring-cortical-electrophysiological-activity-in-a-mouse-model-of-mild-traumatic-brain-injury
#8
Francesca Guida, Serena Boccella, Monica Iannotta, Danilo De Gregorio, Catia Giordano, Carmela Belardo, Rosaria Romano, Enza Palazzo, Maria A Scafuro, Nicola Serra, Vito de Novellis, Francesco Rossi, Sabatino Maione, Livio Luongo
Traumatic brain injury (TBI) represents a major public health problem, which is associated with neurological dysfunction. In severe or moderate cases of TBI, in addition to its high mortality rate, subjects may encounter diverse behavioral dysfunctions. Previous reports suggest that an association between TBI and chronic pain syndromes tends to be more common in patients with mild forms of brain injury. Despite causing minimal brain damage, mild TBI (mTBI) often leads to persistent psychologically debilitating symptoms, which can include anxiety, various forms of memory and learning deficits, and depression...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28315265/sigma-1-receptor-and-ion-channel-dynamics-in-cancer
#9
Olivier Soriani, Raphaël Rapetti-Mauss
SigmaR1 is a multitasking chaperone protein which has mainly been studied in CNS physiological and pathophysiological processes such as pain, memory, neurodegenerative diseases (amyotrophic lateral sclerosis , Parkinson's and Alzheimer's diseases, retinal neurodegeneration ), stroke and addiction . Strikingly, G-protein and ion channels are the main client protein fami lies of this atypical chaperone and the recent advances that have been performed for the last 10 years demonstrate that SigmaR1 is principally activated following tissue injury and disease development to promote cell survival...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315260/introduction-to-sigma-receptors-their-role-in-disease-and-as-therapeutic-targets
#10
Sylvia B Smith
This book highlights contributions from leaders in the field of sigma receptor research. Sigma receptors represent a promising, novel target for the treatment of neurodegenerative diseases, retinal degenerations, pain and substance abuse. Information is presented about tracers for molecular imaging these receptors, the newly determined crystal structure of human sigma 1 receptor and information about sigma 2 receptor. New discoveries about the role of sigma 1 receptors in cancer, pain, neuropsychiatric disorders, learning and memory, neuronal networks and depression are described...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28301977/cognitive-complaints-in-women-with-fibromyalgia-are-they-due-to-depression-or-to-objective-cognitive-dysfunction
#11
Olga Gelonch, Maite Garolera, Joan Valls, Lluís Rosselló, Josep Pifarré
INTRODUCTION: Cognitive complaints are common in fibromyalgia, but it is unclear whether they represent an objective cognitive dysfunction or whether they could be explained by depressive symptoms. Here, we aim to elucidate the frequency of subjective cognitive complaints in a sample of women with fibromyalgia, in addition to analyzing associations between these subjective complaints and objective measures linked to the attention and executive cognitive domains. Finally, we aim to investigate the ability of demographic, clinical, and psychological variables to explain the subjective complaints observed...
March 17, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28296164/brief-clinical-report-a-systematic-review-and-meta-analysis-of-pain-memory-reframing-interventions-for-children-s-needle-procedures
#12
REVIEW
Melanie Noel, C Meghan McMurtry, Maria Pavlova, Anna Taddio
OBJECTIVE: Children's pain memories play a powerful role in shaping future pain experiences. Interventions aiming to reframe children's memories of painful medical procedures hold promise for altering pain memories and improving subsequent pain experience; however, this evidence has not been synthesized. This brief clinical report includes a systematic review and meta-analysis of existing memory-reframing interventions for needle procedures in children and adolescents in order to stimulate future research...
March 14, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28286864/in-vivo-expansion-of-melanoma-specific-t-cells-using-microneedle-arrays-coated-with-immune-polyelectrolyte-multilayers
#13
Qin Zeng, Joshua M Gammon, Lisa H Tostanoski, Yu-Chieh Chiu, Christopher M Jewell
Microneedles (MNs) are micron-scale polymeric or metallic structures that offer distinct advantages for vaccines by efficiently targeting skin-resident immune cells, eliminating injection-associated pain, and improving patient compliance. These advantages, along with recent studies showing therapeutic benefits achieved using traditional intradermal injections in human cancer patients, suggest MN delivery might enhance cancer vaccines and immunotherapies. We recently developed a new class of polyelectrolyte multilayers based on the self-assembly of model peptide antigens and molecular toll-like receptor agonists (TLRa) into ultrathin, conformal coatings...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28278165/indomethacin-counteracts-the-effects-of-chronic-social-defeat-stress-on-emotional-but-not-recognition-memory-in-mice
#14
Aránzazu Duque, Concepción Vinader-Caerols, Santiago Monleón
We have previously observed the impairing effects of chronic social defeat stress (CSDS) on emotional memory in mice. Given the relation between stress and inflammatory processes, we sought to study the effectiveness of the anti-inflammatory indomethacin in reversing the detrimental effects of CSDS on emotional memory in mice. The effects of CSDS and indomethacin on recognition memory were also evaluated. Male CD1 mice were randomly divided into four groups: non-stressed + saline (NS+SAL); non-stressed + indomethacin (NS+IND); stressed + saline (S+SAL); and stressed + indomethacin (S+IND)...
2017: PloS One
https://www.readbyqxmd.com/read/28276853/worsening-of-rest-activity-circadian-rhythm-and-quality-of-life-in-female-breast-cancer-patients-along-progression-of-chemotherapy-cycles
#15
Armiya Sultan, Vivek Choudhary, Arti Parganiha
Chemotherapy and its associated side effects can induce the disruption of circadian rest-activity rhythm and may have negative consequences on health-related quality of life (HRQoL) of cancer patients. In the current study, repeated-measures cross-sectional design was implemented to determine the status of circadian rest-activity rhythm and to assess the HRQoL of newly diagnosed female breast cancer patients those were planned to receive six cycles of chemotherapy. Rest activity and HRQoL were assessed in twenty-five patients during chemotherapy cycles 1st (C1), 3rd (C3), and 6th (C6) immediately after they reported to the outdoor ward of the Regional Cancer Center, Pt...
February 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28269604/effects-of-high-frequency-rtms-on-sleep-deprivation-a-pilot-study
#16
D P Martinez-Cancino, J Azpiroz-Leehan, L Jimenez-Angeles, A Garcia-Quintanar, R Santana-Miranda
Transcranial magnetic stimulation is a neurostimulation technique which has the potential to serve as a unique research tool for investigating a wide variety of fields in cognitive neuroscience. TMS has been approved by the FDA to serve as a treatment to depression and has also been used to evaluate its effects among several conditions such as Alzheimer, Parkinson disease, chronic pain and stroke. High frequency TMS has been previously used with the intention to measure and modulate the negative effects of sleep deprivation in cognitive performance, but there is no consensus about the ideal protocol yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266338/vocally-disruptive-behaviors-management-in-older-people-with-dementia
#17
Caroline Berastegui, Emmanuel Monfort, Bertrand Boudin
Although shouting is a common psycho-behavioral symptom in geriatric institutions, the question of its assessment and treatment remains seldom studied and has rarely been the subject of specific recommendations. The combination of the focus group method and brainstorming has emerged as a methodology both relevant and feasible in geriatric facility to identify the coping strategies used by professionals and generalize guidelines for clinical observation and vocally disruptive behaviors management (shouting)...
March 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28260963/painful-memories-reliability-of-pain-intensity-recall-at-3-months-in-senior-patients
#18
Raoul Daoust, Marie-Josée Sirois, Jacques S Lee, Jeffrey J Perry, Lauren E Griffith, Andrew Worster, Eddy Lang, Jean Paquet, Jean-Marc Chauny, Marcel Émond
Background. Validity of pain recall is questioned in research. Objective. To evaluate the reliability of pain intensity recall for seniors in an emergency department (ED). Methods. This study was part of a prospective multicenter project for seniors (≥65 years old) treated in an ED for minor traumatic injury. Pain intensity (0-10 numerical rating scale) was evaluated at the initial ED visit, at one week (baseline), and 3 months. At three months, patients were asked to recall the pain intensity they had at baseline...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28260291/-andersson-lesion-in-ankylosing-spondylitis-a-clinical-study-of-14-cases
#19
Y H Li, X Y Zhang, Q H Li, D H Zheng, L Dai
Objective: To investigate the clinical characteristics of ankylosing spondylitis (AS) combined Andersson lesion (AL). Methods: The clinical data of patients who were diagnosed as AS combined AL at Sun Yat-sen Memorial Hospital between January 2012 and December 2015 were reviewed retrospectively.SPSS 20.0 software was used for statistical analysis.Data of normal distribution was expressed by x±s (standard deviation) and that of abnormal distribution by median and range. Results: Fourteen patients were enrolled...
February 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28258445/physio-somatic-symptoms-in-schizophrenia-association-with-depression-anxiety-neurocognitive-deficits-and-the-tryptophan-catabolite-pathway
#20
Buranee Kanchanatawan, Sunee Sirivichayakul, Supaksorn Thika, Kiat Ruxrungtham, André F Carvalho, Michel Geffard, George Anderson, Cristiano Noto, Rada Ivanova, Michael Maes
To investigate the frequency of physio-somatic symptoms (PS) symptoms in schizophrenia and their relation to positive, negative and affective symptoms; neurocognitive deficits and impairments in the tryptophan catabolite (TRYCAT) pathway. Eighty four patients with schizophrenia and 40 healthy controls were assessed using the 12 item Fibromyalgia and Chronic Fatigue Syndrome Rating scale (FF) and scales for negative and positive symptoms, depression and anxiety. Cognitive functioning was tested using the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
March 3, 2017: Metabolic Brain Disease
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