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https://www.readbyqxmd.com/read/28533953/interplay-among-pain-intensity-sleep-disturbance-and-emotion-in-patients-with-non-specific-low-back-pain
#1
Shilabant Sen Sribastav, He Peiheng, Long Jun, Li Zemin, Wei Fuxin, Wang Jianru, Liu Hui, Wang Hua, Zheng Zhaomin
BACKGROUND: Low back pain (LBP) is the most common problem worldwide. There are several negative consequences of LBP, such as sleep disorders, work leave, disability, depression, anxiety, and poor quality of life. In this study, we designed to evaluate the prevalence of sleep disturbance in patients with non-specific LBP(NSLBP), and cross-correlation among sleep disorder, anxiety, depression and pain intensity in patients with NSLBP. AIM: In this study, we designed to evaluate the prevalence of sleep disturbance in patients with NSLBP, and cross-correlation among sleep disorder, anxiety, depression and pain intensity in patients with NSLBP...
2017: PeerJ
https://www.readbyqxmd.com/read/28525629/the-association-of-perceived-memory-loss-with-osteoarthritis-and-related-joint-pain-in-a-large-appalachian-population
#2
Kim E Innes, Usha Sambamoorthi
Objective. : Previous studies have documented memory impairment in several chronic pain syndromes. However, the potential link between memory loss and osteoarthritis (OA), the second most common cause of chronic pain, remains little explored. In this cross-sectional study, we examine the association of perceived memory loss to OA and assess the potential mediating influence of sleep and mood disturbance in a large Appalachian population. Design.:  Cross-sectional...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28521778/cortical-kainate-receptors-and-behavioral-anxiety
#3
REVIEW
Min Zhuo
The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in adult animals. Long-term potentiation (LTP) of cortical synapses may play important roles in chronic pain and anxiety. In addition to NMDA and AMPA receptors, kainate (KA) receptors have been found to play roles in synaptic transmission, regulation and presynaptic forms of LTP...
May 18, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28520755/neuropsychological-characteristics-of-gulf-war-illness-a-meta-analysis
#4
Patricia A Janulewicz, Maxine H Krengel, Alexis Maule, Roberta F White, Joanna Cirillo, Emily Sisson, Timothy Heeren, Kimberly Sullivan
OBJECTIVE: Gulf War illness (GWI) is a disorder related to military service in the 1991 GW. Prominent symptoms include fatigue, pain and cognitive problems. These symptoms were reported by GW Veterans (GWV) immediately after the war and were eventually incorporated into case definitions of GWI. Neuropsychological function in GW veterans has been studied both among deployed GWV and in GWV diagnosed with GWI. Results have been inconsistent between and across GW populations. The purpose of the present investigation was to better characterize neuropsychological function in this veteran population...
2017: PloS One
https://www.readbyqxmd.com/read/28515230/crosstalk-from-camp-to-erk1-2-emerges-during-postnatal-maturation-of-nociceptive-neurons-and-is-maintained-during-aging
#5
Joerg Isensee, Cosimo Schild, Frank Schwede, Tim Hucho
Maturation of nociceptive neurons depends on changes of transcription factors, ion channels, and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. If sensitization signaling also changes during development and aging remains so far unknown.Using a novel automated microscopy approach, we quantified changes of intracellular signaling protein expression, of their signaling dynamics, as well as of intracellular signaling cascade wiring in sensory neurons from newborn to senescent rats...
May 17, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28511826/use-of-hypnosis-meditation-and-biofeedback-in-dermatology
#6
Philip D Shenefelt
Hypnosis utilizes trance to access otherwise inaccessible repressed or unconscious memories and features of the psyche and control of physiology not attainable in the ordinary conscious waking state. Medical uses of hypnosis in dermatology include reducing discomfort from itching or skin pain, altering ingrained dysfunctional habits such as scratching, promoting healing of skin disorders, searching for psychosomatic aspects of skin disorders and alleviating them, and reframing cognitive and emotional dysfunctional patterns related to skin disorders...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28511693/antagonistic-action-on-nmda-glun2b-mediated-currents-of-two-peptides-that-were-conantokin-g-structure-based-designed
#7
Edwin A Reyes-Guzman, Nohora Vega-Castro, Edgar A Reyes-Montaño, Esperanza Recio-Pinto
BACKGROUND: The GluN2B subunit of the N-methyl-D-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with various disorders such neuropathic pain and neuronal death following hypoxia. Thus there is an interest in identifying NMDAr antagonists that interact specifically with the GluN2B subunit. Recently based on structural analysis between the GluN2B subunit and conantokin-G, a toxin that interacts selectively with the GluN2B subunit, we designed various peptides that are predicted to act as NMDAr antagonists by interacting with the GluN2B subunit...
May 16, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28511119/effects-of-breviscapine-on-amyloid-beta-1-42-induced-alzheimer-s-disease-mice-a-hplc-qtof-ms-based-plasma-metabonomics-study
#8
Hongjun Xia, Lingling Wu, Mengying Chu, Huimin Feng, Chunliang Lu, Qinghe Wang, Minghai He, Xiaoqun Ge
Herba Erigerontis has long been used to cure apoplexy hemiplegia and precordial pain in China. In addition, the bioactivities of its total flavonoids-breviscapine included inhibiting amyloid beta (Aβ) fibril formation, antioxidation and metal chelating, which are beneficial to treat Alzheimer's disease (AD). Hence, A HPLC-QTOF-MS based plasma metabonomics approach was applied to investigate the neuroprotective effects of breviscapine on intracerebroventricular injection of aggregated Aβ 1-42 induced AD mice for the first time in the study...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28507260/reprogramming-cells-from-gulf-war-veterans-into-neurons-to-study-gulf-war-illness
#9
Liang Qiang, Anand N Rao, Gustavo Mostoslavsky, Marianne F James, Nicole Comfort, Kimberly Sullivan, Peter W Baas
Gulf War illness (GWI), which afflicts at least 25% of veterans who served in the 1990-1991 war in the Persian Gulf, is thought to be caused by deployment exposures to various neurotoxicants, including pesticides, anti-nerve gas pills, and low-level nerve agents including sarin/cyclosarin. GWI is a multisymptom disorder characterized by fatigue, joint pain, cognitive problems, and gastrointestinal complaints. The most prominent symptoms of GWI (memory problems, poor attention/concentration, chronic headaches, mood alterations, and impaired sleep) suggest that the disease primarily affects the CNS...
May 16, 2017: Neurology
https://www.readbyqxmd.com/read/28502042/tale-of-the-good-and-the-bad-cdk5-remodeling-of-the-actin-cytoskeleton-in-the-brain
#10
REVIEW
Kavita Shah, Sandra Rossie
Cdk5 kinase, a cyclin-dependent kinase family member, is a key regulator of cytoskeletal remodeling in the brain. Cdk5 is essential for brain development during embryogenesis. After birth, it is essential for numerous neuronal processes such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity is deregulated in various brain disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and ischemic stroke, resulting in profound remodeling of the neuronal cytoskeleton, loss of synapses, and ultimately neurodegeneration...
May 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28501772/hyperoside-protects-against-chronic-mild-stress-induced-learning-and-memory-deficits
#11
Yeli Gong, Youhua Yang, Xiaoqing Chen, Min Yang, Dan Huang, Rong Yang, Lianying Zhou, Changlei Li, Qiuju Xiong, Zhe Xiong
Hyperoside (quercetin-3-O-b-d-galactosidepyranose) is a plant-derived flavonoid mainly found in fruits, fruit juices (most notably flavanols, flavanones, and anthocyanins) and Chinese traditional medicines. It has been applied to relieve pain and improve cardiovascular functions in clinic. However, the effects of hyperoside on cognitive impairment induced by chronic stress and the underlying molecular mechanisms remain unclear. In the current study, we used chronic mild stress (CMS) rats to investigate the effects of hyperoside on learning and memory and further explore the possible mechanisms...
May 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28484399/biochemical-benefits-diagnosis-and-clinical-risks-evaluation-of-kratom
#12
REVIEW
Dimy Fluyau, Neelambika Revadigar
BACKGROUND: Kratom (Mitragyna speciosa) is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. Kratom is also known as Thom, Thang, and Biak. Its leaves and the teas brewed from them have long been used by people in that region to manage pain and opioid withdrawal and to stave off fatigue. Kratom is actually consumed throughout the world for its stimulant effects and as an opioid substitute (in form of tea, chewed, smoked, or ingested in capsules)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28483271/-mindful-neuropsychology-mindfulness-based-cognitive-remediation
#13
E Bulzacka, S Lavault, A Pelissolo, C Bagnis Isnard
OBJECTIVES: Mindfulness based interventions (MBI) have recently gained much interest in western medicine. MBSR paradigm is based on teaching participants to pay complete attention to the present experience and act nonjudgmentally towards stressful events. During this mental practice the meditator focuses his or her attention on the sensations of the body. While the distractions (mental images, thoughts, emotional or somatic states) arise the participant is taught to acknowledge discursive thoughts and cultivate the state of awareness without immediate reaction...
May 5, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28482941/disrupted-identities-movement-mind-and-memory-in-parkinson-s-disease
#14
Iracema Leroi
For the many clinicians au fait with the history of the clinical description of Parkinson's disease, they will be aware that the very earliest description of James Parkinson's "Shaking Palsy" in 1817 explicitly excluded the involvement of cognitive and emotional processes as manifestations of the disease. Within a short time following his treatise, it became all too clear to those in the field that Parkinson's disease is more than just a motor disorder, and as was aptly conceptualized by Paul McHugh, Professor of Psychiatry at Johns Hopkins Hospital from 1975 until 2001, Parkinson's disease is closer to being a "triadic disorder," encompassing motor, cognitive, and psychiatric elements (McHugh, 1989)...
June 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28480126/the-life-process-of-children-who-survived-the-manjil-earthquake-a-decaying-or-renewing-process
#15
Abbas Shamsalinia, Fatemeh Ghaffari, Nahid Dehghan-Nayeri, Sarieh Poortaghi
INTRODUCTION: Among earthquake survivors, children are more vulnerable than other age groups due to their exposure to harrowing scenes of devastation as well as their drastically new living situations that result from an earthquake disaster. The life process of children survivors undergoes many different changes that are affected by a wide range of factors. Understanding the life process of these children may lead to effective outcomes and interventions. In addition, observing children survivors establishes knowledge and understanding of the challenges that correspond with earthquake disasters...
April 4, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28478818/the-multi-factorial-origins-of-chronic-traumatic-encephalopathy-cte-symptomology-in-post-career-athletes-the-athlete-post-career-adjustment-ap-ca-model
#16
Michael Gaetz
CTE has two prominent components: the pathophysiology that is detected in the brain postmortem and the symptomology that is present in the interval between retirement and end of life. CTE symptomology has been noted to include memory difficulties, aggression, depression, explosivity, and executive dysfunction at early stages progressing to problems with attention, mood swings, visuospatial difficulties, confusion, progressive dementia, and suicidality (e.g. McKee et al. (2012), Omalu et al. (2010a-c), McKee et al...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28468028/effects-of-acute-administration-of-adipokinetic-hormone-on-depression-anxiety-pain-locomotion-and-memory-in-mice
#17
Oguz Mutlu, Guner Ulak, Furuzan Akar, Faruk Erden, Ipek Komsuoglu Celikyurt, Emine Bektas, Pelin Tanyeri, Havva Kaya
The neurosecretory cells in the corpus cardiacum of insects synthesize a set of hormones that are called adipokinetic, hypertrehalosemic or hyperprolinemic depending on the insect in question. They are the Adipokinetic Hormone/Red Pigment-Concentrating Hormone (AKH/RPCH) family of peptides. The present study investigated the effects of acute administration of Locusta Migratoria (Locmi-AKHII) and Anax Imperator (Anaim-AKH) on depression, anxiety, pain (analgesy), locomotion and memory in mice in forced swimming (FST), elevated plus maze (EPM), hot plate, locomotor activity and passive avoidance tests...
April 30, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28458551/levodopa-responsive-depression-associated-with-corticobasal-degeneration-a-case-report
#18
Natsumi Tarakita, Haruo Nishijima, Norio Yasui-Furukori
A 60-year-old female was treated for depression with the antidepressant paroxetine for 13 years. The patient had experienced clumsiness and mild rigidity in the left hand, and had agraphia and mild subjective memory complaints for 3 years prior to admission in our hospital. She experienced exacerbated depression that included worsened depressive mood, lowered motivation, and suicidal ideation without precipitating stressful life events for 2 years prior to admission, and although she had continued taking the antidepressant, these symptoms were not ameliorated by increasing the dose of paroxetine...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28453603/the-effect-of-insomnia-on-neuropsychological-functioning-in-patients-with-comorbid-symptoms-of-pain-fatigue-and-mood-disorders
#19
Julie Aasvik, Tore C Stiles, Astrid Woodhouse, Petter Borchgrevink, Nils Inge Landrø
Objectives: To examine if elevated symptoms of insomnia affects neuropsychological functioning in patients with concurrent symptoms of pain, fatigue, and mood disorders. Methods and results: A total of seventy-six subjects participated in this (cross-sectional) study. Based on the cut-off score guidelines from The Insomnia Severity Index subjects were assigned to either a clinical insomnia group (N = 35) or a comparison group (N = 41). Factors such as age, general cognitive functioning, and symptoms of pain, fatigue, depression, and anxiety did not differ between the groups...
April 27, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28453445/the-effectiveness-of-a-cognitive-behavioral-exercise-approach-cbea-compared-to-usual-care-in-patients-with-a-whiplash-associated-disorder-a-quasi-experimental-clinical-trial
#20
Jorge Hugo Villafañe, Davide Perucchini, Joshua A Cleland, Cristina Barbieri, Fernanda de Lima E Sá Resende, Stefano Negrini
BACKGROUND: Whiplash Associated Disorders (WAD) is a biopsychosocial problem, education may be an essential part in the treatment and the prevention of chronic WAD. However, it is still unclear which type of educative intervention has already been used in WAD patients and how effective such interventions are. OBJECTIVE: To examine the effectiveness of a cognitive behavioral exercises approach (CBEA) for self-training of the neck relative to usual care in individuals with WAD in acute phase...
April 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
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