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https://www.readbyqxmd.com/read/27899280/behavioural-phenotype-of-histamine-h4-receptor-knockout-mice-focus-on-central-neuronal-functions
#1
Maria Domenica Sanna, Carla Ghelardini, Robin L Thurmond, Emanuela Masini, Nicoletta Galeotti
The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-KO) mice. Mice lacking H4R underwent behavioural studies to evaluate locomotor activity, pain perception, anxiety, depression, memory and feeding behaviour. H4R-KO mice showed a significant increase in ambulation in an open field as well as in exploratory activity in the absence of any modification of motor coordination...
November 26, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27898075/maternal-high-fat-diet-prevents-developmental-programming-by-early-life-stress
#2
M Rincel, A L Lépinay, P Delage, J Fioramonti, V S Théodorou, S Layé, M Darnaudéry
Anxiety disorders and depression are well-documented in subjects exposed to adverse childhood events. Recently, maternal obesity and/or maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here using an animal model in rats, we explored the combinatorial effects of a maternal HFD (40% of energy from fat without impact on maternal weight; during gestation and lactation) and maternal separation (MS) in offspring. In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4)...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27888073/early-life-inflammation-with-lps-delays-fear-extinction-in-adult-rodents
#3
V M Doenni, C M Song, M N Hill, Q J Pittman
A large body of evidence has been brought forward connecting developmental immune activation to abnormal fear and anxiety levels. Anxiety disorders have extremely high lifetime prevalence, yet susceptibility factors that contribute to their emergence are poorly understood. In this research we investigated whether an inflammatory insult early in life can alter the response to fear conditioning in adulthood. Fear learning and extinction are important and adaptive behaviors, mediated largely by the amygdala and its interconnectivity with cortico-limbic circuits...
November 22, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27881995/pattern-of-initial-clinical-manifestations-of-systemic-lupus-erythematosus-in-a-tertiary-care-hospital
#4
Shabnam Batool, Nighat Mir Ahmad, Muhammad Ahmed Saeed, Sumaira Farman
OBJECTIVE: To determine the pattern of initial clinical manifestations of Systemic Lupus Erythematosus (SLE) and to compare these features with those recorded elsewhere in Pakistan. METHODS: This cross-sectional, descriptive study was performed in the Department of Rheumatology, Fatima Memorial Hospital, Lahore, Pakistan, from November 2015 to January 2016. Sixty one patients of SLE diagnosed as per ACR (American College of Rheumatology) 1982 revised criteria, were enrolled...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27875034/risk-factors-of-post-traumatic-stress-symptoms-in-patients-with-cancer
#5
Yu-Hua Lin, Chia-Chan Kao, Shu-Fen Wu, Shu-Ling Hung, Hsing-Yu Yang, Hong-Yu Tung
AIM AND OBJECTIVES: To determine the level of PTSS and to identify demographics, disease history, and clinical symptoms that were associated with PTSS among gynecological, breast, or colorectal cancer patients in Taiwan. BACKGROUND: Literature indicated that 7.3 % to 35.2% of patients with cancer had experienced level of post-traumatic stress symptoms (PTSS). However, the PTSS among patients with cancer in Taiwan was not documented. DESIGN: A cross-sectional study...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27870403/sex-differences-in-social-cognition-the-case-of-face-processing
#6
Alice Mado Proverbio
Several studies have demonstrated that women show a greater interest for social information and empathic attitude than men. This article reviews studies on sex differences in the brain, with particular reference to how males and females process faces and facial expressions, social interactions, pain of others, infant faces, faces in things (pareidolia phenomenon), opposite-sex faces, humans vs. landscapes, incongruent behavior, motor actions, biological motion, erotic pictures, and emotional information. Sex differences in oxytocin-based attachment response and emotional memory are also mentioned...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27867309/gender-differences-in-symptoms-health-related-quality-of-life-sleep-quality-mental-health-cognitive-performance-pain-cognition-and-positive-health-in-spanish-fibromyalgia-individuals-the-al-%C3%A3-ndalus-project
#7
Víctor Segura-Jiménez, Fernando Estévez-López, Alberto Soriano-Maldonado, Inmaculada C Álvarez-Gallardo, Manuel Delgado-Fernández, Jonatan R Ruiz, Virginia A Aparicio
Objective. To test the gender differences in tenderness, impact of fibromyalgia, health-related quality of life, fatigue, sleep quality, mental health, cognitive performance, pain-cognition, and positive health in Spanish fibromyalgia patients and in age-matched nonfibromyalgia individuals from the same region. To test the optimal cut-off score of the different tender points for women and men. Methods. A total of 405 (384 women) fibromyalgia versus 247 (195 women) nonfibromyalgia control participants from southern Spain (Andalusia) took part in this cross-sectional study...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/27845293/character-of-the-changes-in-fear-motivated-declarative-memory-in-the-high-immobilization-depressive-rats
#8
N Nachkebia, M Shavgulidze, M Babilodze, E Chkhartishvili, N Rogava
Present study investigated possible differences in the learning and memory of declarative memory task in rats selected according to the differences in immobilization response that is in high immobilization "depressive" and low immobilization "non-depressive" rats. Understanding the character of learning and memory disturbances in basal conditions of animal models of depression is still very topical for more intimate definition of the pathophysiology of major depressive disorder and appropriate searching the ways of its correction...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27825613/the-patient-reported-outcome-of-chronic-pain-after-the-harvest-of-anterior-iliac-bone-for-anterior-cervical-arthrodesis
#9
Chi Heon Kim, Chun Kee Chung, Yunhee Choi, Sun Tae Hwang, Sung-Mi Kim, Sung Bae Park
BACKGROUND: Anterior cervical fusion (ACF) with autologous iliac bone graft is a traditional surgical method, but high rate of chronic pain (30%) at the anterior iliac crest presents a considerable hindrance to harvesting iliac bone. The memory of acute pain may become fainter as time progresses, and the incidence of chronic pain may not be as high as previously reported. The primary objective was to show the patient-reported outcome of chronic pain in the anterior iliac crest. METHODS: Telephone surveys were conducted for patients with single-level ACF (group-S; n=72; M:F=52:20; median age, 53years), multiple-level ACF (group-M; n=61; M:F=40:21; 56years) using autologous iliac bone, and single-level ACF with a stand-alone cage (group-C; n=53; M:F=38:15; 51years)...
November 4, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27821966/effects-of-neurofeedback-training-on-the-brain-wave-of-adults-with-forward-head-posture
#10
Hyun-Ju Oh, Gui-Bin Song
[Purpose] The purpose of the present study was to examine the effects of neurofeedback training on electroencephalogram changes in the cervical spine in adults with forward head posture through x-ray. [Subjects and Methods] The subjects of the study were 40 college students with forward head posture, randomly divided into a neurofeedback training group (NFTG, n=20) and a control group (CG, n=20). The neurofeedback training group performed six sessions of pottery and archery games, each for two minutes, three times per week for four weeks, while using the neurofeedback system...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27812328/adverse-social-experiences-in-adolescent-rats-result-in-enduring-effects-on-social-competence-pain-sensitivity-and-endocannabinoid-signaling
#11
Peggy Schneider, Laura Bindila, Christian Schmahl, Martin Bohus, Andreas Meyer-Lindenberg, Beat Lutz, Rainer Spanagel, Miriam Schneider
Social affiliation is essential for many species and gains significant importance during adolescence. Disturbances in social affiliation, in particular social rejection experiences during adolescence, affect an individual's well-being and are involved in the emergence of psychiatric disorders. The underlying mechanisms are still unknown, partly because of a lack of valid animal models. By using a novel animal model for social peer-rejection, which compromises adolescent rats in their ability to appropriately engage in playful activities, here we report on persistent impairments in social behavior and dysregulations in the endocannabinoid (eCB) system...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27805769/basal-ganglia-dysfunction-in-complex-regional-pain-syndrome-a-valid-hypothesis
#12
REVIEW
M Azqueta-Gavaldon, H Schulte-Göcking, C Storz, S Azad, A Reiners, D Borsook, L Becerra, E Kraft
: Complex regional pain syndrome (CRPS) is a poorly understood pain disorder of the limbs. Maladaptive cortical plasticity has been shown to play a major role in its pathophysiological presentation. Recently, there is increasing interest in the role of the basal ganglia (BG), since clinical findings and neuroimaging studies point to possible BG involvement in CRPS. CRPS symptoms are often characterized by movement disorders associated with BG dysfunction. Very frequently, dystonia and tremor are reported and, to a lesser extent, myoclonus...
November 2, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27803403/impaired-pain-processing-correlates-with-cognitive-impairment-in-parkinson-s-disease
#13
Akinori Okada, Tomohiko Nakamura, Junichiro Suzuki, Masashi Suzuki, Masaaki Hirayama, Masahisa Katsuno, Gen Sobue
Objective Pain and cognitive impairment are important clinical features in patients with Parkinson's disease (PD). Although pain processing is associated with the limbic system, which is also closely linked to the cognitive function, the association between pain and cognitive impairment in PD is still not well understood. The aim of the study was to investigate the association between pain processing and cognitive impairment in patients with PD. Methods Forty-three patients with PD and 22 healthy subjects were studied...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27792253/%C3%AE-5gabaa-receptors-mediate-tonic-inhibition-in-the-spinal-cord-dorsal-horn-and-contribute-to-the-resolution-of-hyperalgesia
#14
Jimena Perez-Sanchez, Louis-Etienne Lorenzo, Irene Lecker, Agnieszka A Zurek, Charalampos Labrakakis, Erica M Bridgwater, Beverley A Orser, Yves De Koninck, Robert P Bonin
Neuronal inhibition mediated by GABAA receptors constrains nociceptive processing in the spinal cord, and loss of GABAergic inhibition can produce allodynia and hyperalgesia. Extrasynaptic α5 subunit-containing GABAA receptors (α5GABAA Rs) generate a tonic conductance that inhibits neuronal activity and constrains learning and memory; however, it is unclear whether α5GABAA Rs similarly generate a tonic conductance in the spinal cord dorsal horn to constrain nociception. We assessed the distribution of α5GABAA Rs in the spinal cord dorsal horn by immunohistochemical analysis, and the activity and function of α5GABAA Rs in neurons of the superficial dorsal horn using electrophysiological and behavioral approaches in male, null-mutant mice lacking the GABAA R α5 subunit (Gabra5-/-) and wild-type mice (WT)...
October 28, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27788040/neuropeptide-s-receptor-ligands-a-patent-review-2005-2016
#15
Chiara Ruzza, Girolamo Calò, Salvatore Di Maro, Salvatore Pacifico, Claudio Trapella, Severo Salvadori, Delia Preti, Remo Guerrini
Neuropeptide S (NPS) is a 20-residue peptide and endogenous ligand of the NPS receptor (NPSR). This receptor was a formerly orphan GPCR whose activation increases calcium and cyclic adenosine monophosphate levels. The NPS/NPSR system is expressed in several brain regions where it controls important biological functions including locomotor activity, arousal and sleep, anxiety, food intake, memory, pain, and drug addiction. Areas covered: This review furnishes an updated overview of the patent literature covering NPSR ligands since 2005, when the first example of an NPSR antagonist was disclosed...
November 9, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27776522/inositol-1-4-5-trisphosphate-receptor-type-1-autoantibodies-in-paraneoplastic-and-non-paraneoplastic-peripheral-neuropathy
#16
Sven Jarius, Marius Ringelstein, Jürgen Haas, Irina I Serysheva, Lars Komorowski, Kai Fechner, Klaus-Peter Wandinger, Philipp Albrecht, Harald Hefter, Andreas Moser, Eva Neuen-Jacob, Hans-Peter Hartung, Brigitte Wildemann, Orhan Aktas
BACKGROUND: Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia. However, ITPR1 is expressed not only by Purkinje cells but also in the anterior horn of the spinal cord, in the substantia gelatinosa and in the motor, sensory (including the dorsal root ganglia) and autonomic peripheral nervous system, suggesting that the clinical spectrum associated with autoimmunity to ITPR1 may be broader than initially thought...
October 24, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27771379/novel-highly-potent-and-in%C3%A2-vivo-active-inhibitor-of-gaba-transporter-subtype-1-with-anticonvulsant-anxiolytic-antidepressant-and-antinociceptive-properties
#17
Kinga Sałat, Adrian Podkowa, Natalia Malikowska, Felix Kern, Jörg Pabel, Ewelina Wojcieszak, Katarzyna Kulig, Klaus T Wanner, Beata Strach, Elżbieta Wyska
BACKGROUND AND PURPOSE: Since GABAergic dysfunction underlies a variety of neurological and psychiatric disorders, numerous strategies leading to the augmentation of GABAergic neurotransmission have been introduced. One of them is the inhibition of GABA reuptake from the synaptic cleft mediated by four plasma membrane GABA transporters (GAT1-4). GAT1 which is exclusively expressed in the brain is an interesting target for centrally acting drugs. In this research, pharmacological properties of a novel, highly potent and selective inhibitor of GAT1, the guvacine derivative named DDPM-2571, were assessed in vivo...
October 19, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27766605/evaluation-of-patients-with-multiple-sclerosis-using-reverse-nutech-functional-score-and-expanded-disability-status-scale-after-human-embryonic-stem-cell-therapy
#18
Geeta Shroff
BACKGROUND: The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be limited in assessing various symptoms of MS that are important. Our study aimed at evaluating the efficacy of a new scoring system, reverse nutech functional score (RNFS) as compared to EDSS in assessing patients with MS treated with human embryonic stem cell (hESC) therapy...
December 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27760055/patient-recollection-of-icu-procedural-pain-and-post-icu-burden-the-memory-study
#19
Kathleen A Puntillo, Adeline Max, Marine Chaize, Gerald Chanques, Elie Azoulay
OBJECTIVE: To assess patients' recollections of in-ICU procedural pain and its impact on post-ICU burden. DESIGN: Prospective longitudinal study of patients who underwent ICU procedures. SETTING: Thirty-four ICUs in France and Belgium. PATIENTS: Two hundred thirty-six patients who had undergone ICU procedures. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: Patients were interviewed 3-16 months after hospitalization about: 1) recall of procedural pain intensity and pain distress (on 0-10 numeric rating scale); 2) current pain; that is, having pain in the past week that was not present before hospitalization; and 3) presence of traumatic stress (Impact of Events Scale)...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27756974/managing-behavioural-and-psychological-symptoms-in-dementia
#20
Stephen Macfarlane, Daniel O'Connor
Most patients with dementia have some behavioural and psychological symptoms. While aggression and agitation are easily recognised, symptoms such as apathy may be overlooked. Behavioural and psychological symptoms should be managed without drugs whenever possible. Although there is little evidence to support their use, antipsychotic drugs are often prescribed to people with dementia. Before prescribing it is important to exclude other causes of altered behaviour, such as pain or infection. Some symptoms may be artefacts of memory loss rather than psychosis...
August 2016: Australian Prescriber
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