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memory of pain

Carole Cometti, Christos Païzis, Audrey Casteleira, Guillaume Pons, Nicolas Babault
Background: We evaluated the effects of a mixed reality (MR) head-mounted deviceon some cognitiveand physiological functions during 90 min tasks in an attempt to determine their safety for workers. Methods: A total of 12 volunteers performed 90-min intellectual and manual tasks with and without MR glasses. Balance, Stroop, and memory tests were conducted before, during and after these tasks. Heart rate and electromyographic activity of some muscles were recorded...
2018: PeerJ
Maitane García, Imanol Amayra, Esther Lázaro, Juan Francisco López-Paz, Oscar Martínez, Manuel Pérez, Sarah Berrocoso, Mohammad Al-Rashaida
BACKGROUND: Previous studies have suggested an association of Chiari Malformation type I (CM-I) and cognitive deficits. CM-I is a neurological disorder characterized by a descent of cerebellar tonsils into the foramen magnum, resulting in overcrowding of the upper cervical spine region. Posterior fossa decompression (PFD) is the surgical treatment of choice, however, the literature on the consequences for patients is mainly reduced to the assessment of physical symptoms. METHODS: Data from a neuropsychological assessment of 76 patients with CM-I, both with PFD (n=37) and wihout PFD (n= 39) surgery, and 76 healthy controls, matched by gender, age and years of education are reported...
November 6, 2018: Neuropsychologia
Danielle Jacobson, Emily Glazer, Robin Mason, Deanna Duplessis, Kimberly Blom, Janice Du Mont, Navmeet Jassal, Gillian Einstein
Many of the Somali women who have immigrated to other countries, including Canada, have experienced Female Genital Circumcision/ Mutilation/ Cutting (FGC). While there is literature on the medical aspects of FGC, we were interested in understanding the daily life experiences and bodily sensations of Somali-Canadian women in the context of FGC. Fourteen women living in the Greater Toronto Area were interviewed. Interview data were analyzed using a phenomenological approach. We found that the memory of the ceremonial cutting was vivid but was frequently described with acceptance and resignation-as something that just is; that was normal given the particular context, familial and cultural, and their young age...
2018: PloS One
Charles Van Liew, Karissa Standridge, Gabriel Leon, Terry A Cronan
AIM: To evaluate pain experiences and memories in fibromyalgia (FM) patients over time. METHOD: Participants included 572 females who were members of a large health maintenance organization who had a diagnosis of FM syndrome (FMS) and met inclusion criteria for the study. Recruitment was for an intervention study that tested the effects of social support and education treatment arms, but there were no treatment effects. Reports of experiential pain (EP), historical peak pain (HPP), and historical valley pain (HVP) for FM were collected...
November 5, 2018: International Journal of Rheumatic Diseases
Zi-Chen Hao, Yan Xia, Jiang-Hong Wu, Yun-Tong Zhang, Shuo-Gui Xu
PURPOSE: To compare the outcomes of the arched shape-memory connector (ASC) only fixation and the lateral one-third tubular plate fixation in managing unstable Type A or B lateral malleolus fractures according to the Weber (AO) classification, and to evaluate the feasibility and reliability of ASC only fixation in treating these fractures. METHODS: From January 2010 to January 2015, 148 patients with Type A or B (Weber (AO) classification) lateral malleolus fractures treated with the arched shape-memory connector (ASC) only fixation or lateral plate fixation were included...
October 30, 2018: Injury
Judith Lacey, Anna J Lomax, Catriona McNeil, Michael Marthick, David Levy, Steven Kao, Theresa Nielsen, Haryana M Dhillon
INTRODUCTION: Increasing numbers of metastatic melanoma (MM) patients are receiving immunotherapy treatment, including pembrolizumab, and the impact on their well-being is underexplored. OBJECTIVES: To assess the feasibility of a multimodal supportive care program to MM patients being treated with pembrolizumab. METHODS: This pre-post-test feasibility cohort study recruited MM participants treated with pembrolizumab: (i) supportive care intervention with usual care and (ii) usual care...
November 3, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Hamid Ahmadian-Moghadam, Mitra-Sadat Sadat-Shirazi, Mohammad-Reza Zarrindast
Over the last 35 years, the continuous discovery of novel neuropeptides has been the key to the better understanding of how the central nervous system has integrated with neuronal signals and behavioral responses. Cocaine and amphetamine-regulated transcript (CART) was discovered in 1995 in the rat striatum but later was found to be highly expressed in the hypothalamus. The widespread distribution of CART peptide in the brain complicated the understanding of the role played by this neurotransmitter. The main objective of the current compact review is to piece together the fragments of available information about origin, expression, distribution, projection, and function of CART peptides...
October 31, 2018: Peptides
Antonino Cattaneo, Simona Capsoni
Nerve Growth Factor (NGF) is a therapeutic candidate for Alzheimer's disease, based on its well known actions on basal forebrain cholinergic neurons. However, because of its pro-nociceptive activity, in current clinical trials NGF has to be administered intraparenchymally into the brain by neurosurgery via cell or gene therapy approaches. To prevent the NGF pain-inducing collateral effects, thus avoiding the necessity for local brain injection, we developed painless NGF (hNGFp), based on the human genetic disease Hereditary Sensory and Autonomic Neuropathy type V (HSAN V)...
November 1, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Tracy A Smith, Jane M Ingham, Christine R Jenkins
INTRODUCTION: Non-invasive ventilation(NIV) is commonly used to manage acute respiratory failure due to decompensated cardiorespiratory disease. We describe symptom burden in this population. METHODS: Fifty, consecutive, consenting, English speaking, cognitively intact patients, admitted to wards other than the intensive care unit (ICU) in a tertiary teaching hospital and treated with NIV for hypercapnic respiratory failure, were recruited. The 14-item Condensed Memorial Symptom Assessment Scale was used to assess physical and psychological symptoms within 36 hours of commencing NIV...
October 30, 2018: Journal of Pain and Symptom Management
A de St Maurice, E Ervin, R Orone, M Choi, E K Dokubo, P E Rollin, S T Nichol, D Williams, J Brown, R Sacra, J Fankhauser, B Knust
Background: The Eternal Love Winning Africa (ELWA) Clinic was the first clinic to provide free, comprehensive care to Ebola virus disease (EVD) survivors in Liberia. The objectives of this analysis were to describe the demographics and symptoms of EVD survivors at ELWA from January 2015 through March 2017 and to identify risk factors for development of sequelae. Methods: Patients' demographic and clinical information was collected by chart review in June 2016 and March 2017...
October 2018: Open Forum Infectious Diseases
Yusuke Noguchi, Yugo Kawashima, Megumi Maruyama, Hiroko Kawara, Yoko Tokuyama, Kiyoshi Uchiyama, Yoshihiro Shimizu
Paclitaxel and nanoparticle albumin-bound paclitaxel are known to cause adverse events of eye disorders, such as cystoid macular edema. However, at present, the risk factors remain unclear. Therefore, risk factors for eye disorders caused by paclitaxel and nanoparticle albumin-bound paclitaxel were studied. This retrospective study targeted patients who were newly administered paclitaxel or nanoparticle albumin-bound paclitaxel at Kyoto Okamoto Memorial Hospital between April 1, 2012, and March 31, 2017. Eye disorder occurrence was defined as an event in which the pharmacist confirmed the symptoms in a patient interview and the ophthalmologist diagnosed the disorder...
2018: Biological & Pharmaceutical Bulletin
Ana Isabel Fraguas-Sánchez, Ana Isabel Torres-Suárez
Cannabinoid receptors, endocannabinoids and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system. In recent decades, the endocannabinoid system has attracted considerable interest as a potential therapeutic target in numerous pathological conditions. Its involvement in several physiological processes is well known, such as in energy balance, appetite stimulation, blood pressure, pain modulation, embryogenesis, nausea and vomiting control, memory, learning and immune response, among others, as well as in pathological conditions where it exerts a protective role in the development of certain disorders...
October 29, 2018: Drugs
Yaeesh Sardiwalla, Gail Eskes, Andre Bernard, Ronald B George, Michael Schmidt
PURPOSE: Postoperative cognitive dysfunction is difficult to predict and diagnose, and can have severe consequences in the long term. The purpose of our study was to examine the feasibility of using a computerised test battery, the Dalhousie Computerized Assessment Battery in the perioperative clinic to detect cognitive changes after surgery. METHODS: Fifty patients were recruited for this study. Patients completed the Dalhousie Computerized Assessment Battery and tests of general cognition, mood and pain at baseline and at three months postoperatively...
October 29, 2018: Journal of Perioperative Practice
Gabriela de A Lamarca, Mario V Vettore, Angela M Monteiro da Silva
The aim of this study was to investigate the association of stress and anxiety with the expectation, perception and memory of dental pain among schoolchildren. A follow-up study involving 46 children aged 9 to 12 years was conducted in a public school in the city of Petropolis (RJ), Brazil. Demographic characteristics, stress (children's stress scale), and state and trait anxiety (state⁻trait anxiety inventory) were recorded before a dental procedure to restore the occlusal surface of a permanent first molar under local anaesthetic...
October 22, 2018: Dentistry journal
Tayo Katano, Keizo Takao, Manabu Abe, Maya Yamazaki, Masahiko Watanabe, Tsuyoshi Miyakawa, Kenji Sakimura, Seiji Ito
Calcium/calmodulin-dependent serine protein kinase (CASK)-interacting protein 1 (Caskin1) is a direct binding partner of the synaptic adaptor protein CASK. Because Caskin1 forms homo-multimers and binds not only CASK but also other neuronal proteins in vitro, it is anticipated to have neural functions; but its exact role in mammals remains unclear. Previously, we showed that the concentration of Caskin1 in the spinal dorsal horn increases under chronic pain. To characterize this protein, we generated Caskin1-knockout (Caskin1-KO) mice and specific anti-Caskin1 antibodies...
October 25, 2018: Molecular Brain
Sebastiano Mercadante, Claudio Adile, Patrizia Ferrera, Andrea Cortegiani, Alessandra Casuccio
AIM: The aim of this study was to investigate the relationship between delirium and symptom expression in patients with advanced cancer admitted to an acute supportive/palliative care unit (ASPCU). METHODS: A consecutive sample of patients with advanced cancer who were admitted to an ASPCU was prospectively assessed for a period of 10 months. The Edmonton Symptom Assessment Scale (ESAS) and the MDAS (Memorial Delirium Assessment Scale) were measured at admission (T0) and after 7 days of palliative care (T7)...
October 24, 2018: Oncologist
Nicola Allegri, Simona Mennuni, Eliana Rulli, Nicola Vanacore, Oscar Corli, Irene Floriani, Irene De Simone, Massimo Allegri, S Govoni, Tomaso Vecchi, Giorgio Sandrini, Davide Liccione, Elena Biagioli
BACKGROUND AND OBJECTIVE: Opioid treatments are often prolonged because of the pathology causing pain. We focused on the cognitive functions in chronic pain patients treated with opioids. This topic is currently controversial, but in practice the consequences are important in patients' daily life, social interactions, working ability and driving. DATABASE AND DATA TREATMENT: Medline and Embase databases were searched for eligible articles. We included studies: enrolling patients with chronic non-cancer pain; under opioids treatment; with a control group not using opioids; cognitive functions evaluated with specific tests...
October 24, 2018: Pain Practice: the Official Journal of World Institute of Pain
Ashley F Curtis, Jacob M Williams, Karin J M McCoy, Christina S McCrae
STUDY OBJECTIVES: The goal of this study was to examine daily associations between sleep and cognition in older adults suffering from insomnia, with or without a history of chronic pain. METHODS: Sixty older adults with insomnia and a history of chronic pain (HxCP; n = 33, mean age = 69.5 years, standard deviation = 7.8) or no history of chronic pain (NCP; n = 27, mean age = 69.7 years, standard deviation = 7.9) completed 14 days of diaries and actigraphy, measuring sleep onset latency (SOL), wake after sleep onset (WASO), sleep efficiency (SE), and sleep quality...
October 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Lu Fan, Ya-Bin Sun, Ze-Kun Sun, Ning Wang, Fei Luo, Feng Yu, Jin-Yan Wang
Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory. In experiment 1, MMNs elicited by standard and deviant auditory stimuli at short and long inter-stimulus intervals (ISIs) were compared between trigeminal neuralgia (TN) patients and demographically matched healthy controls (HCs)...
October 23, 2018: Scientific Reports
Jenifer Sassarini, Mahesh Perera, Keith Spowart, Kay McAllister, Judith Fraser, Ros Glasspool, Rosie Harrand, Marina Chitoni, Sheila Stallard, Mary-Ann Lumsden
Cancer treatment may result in loss of ovarian function through surgical removal of the ovaries, chemotherapy or radiation. While menopausal symptoms, such as hot flushes, night sweats, sleep disturbance, memory concerns and mood issues can be extremely bothersome to some women going through menopause naturally, women who undergo an induced menopause usually experience more sudden and severe symptoms. Pain and vaginal dryness can occur whether a woman has a sexual partner or not. In women with breast cancer, the aetiology of impaired sexual functioning, and lowered sexual desire, is often multifactorial, and may be related to physical and/or psychological reasons...
October 23, 2018: Post Reproductive Health
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