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https://www.readbyqxmd.com/read/30010543/models-for-nociception-stimulation-and-memory-effects-in-awake-and-aware-healthy-individuals
#1
Dana Copot, Clara Mihaela Ionescu
OBJECTIVE: This paper introduces a primer in the healthcare practice, namely a mathematical model and methodology for detecting and analysing nociceptor stimulation followed by related tissue memory effects. METHODS: Non-invasive nociceptor stimulus protocol and prototype device for measuring bioimpedance is provided. Various time instants, sensor location and stimulus train have been analysed. RESULTS: The method and model indicate that nociceptor stimulation perceived as pain in awake healthy volunteers is non-invasively detected...
July 13, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/30004021/the-effect-of-pain-on-major-cognitive-impairment-in-older-adults
#2
Guusje van der Leeuw, Emmeline Ayers, Suzanne G Leveille, Annette H Blankenstein, Henriette E van der Horst, Joe Verghese
Older adults frequently report pain; cross-sectional studies have shown that pain is associated with worse cognitive function. However, longitudinal studies are lacking. We prospectively studied 441 participants without dementia, including 285 with pain, aged 65 years and older, enrolled in the Central Control of Mobility in Aging Study, a prospective cohort study. We analyzed the longitudinal association between pain (Medical Outcomes Study pain severity scale) and major cognitive impairment (Repeatable Battery for the Assessment of Neuropsychological Status and the Trail Making Test Delta) using Cox regression analysis adjusted for age, gender, ethnicity and education...
July 9, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29999390/gain-without-pain-glucose-promotes-cognitive-engagement-and-protects-positive-affect-in-older-adults
#3
Konstantinos Mantantzis, Elizabeth A Maylor, Friederike Schlaghecken
When faced with a cognitively demanding task, older adults tend to disengage and withdraw effort. At the same time, their usual processing preference for positive information disappears. Providing glucose as an energy resource is known to improve cognitive performance and reinstate older adults' positivity preference. Here, we examined whether glucose can help older adults to exert more effort under high difficulty conditions, and if so, whether such increase is accompanied by a change in positive affect. Fifty-three young and 58 older adults consumed a glucose or a placebo drink and completed a memory-search task at three levels of difficulty...
July 12, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29994924/exercise-reverses-nociceptive-sensitization-upregulated-neuropeptide-signaling-inflammatory-changes-anxiety-and-memory-impairment-in-a-mouse-tibia-fracture-model
#4
Xiaoyou Shi, Tian-Zhi Guo, Wenwu Li, Peyman Sahbaie, Kenner C Rice, Agnieszka Sulima, J David Clark, Wade S Kingery
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: This study tested the hypothesis that ad lib running wheel exercise in a tibia fracture model of complex regional pain syndrome can reverse hindlimb nociceptive sensitization and inflammation in mice. METHODS: Three weeks after tibia fracture, the cast was removed and hindlimb von Frey thresholds and unweighting were tested; the mice were then randomized to either ad lib access to a running wheel for 4 weeks or no wheel access...
July 10, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29990297/clinical-and-analytical-experience-of-the-national-poison-control-centre-with-synthetic-cannabinoids
#5
Slavica Vučinić, Vesna Kilibarda, Snežana Đorđević, Dragana Đorđević, Nataša Perković-Vukčević, Gordana Vuković-Ercegović, Biljana Antonijević, Marijana Ćurčić, Evica Antonijević, Gordana Brajković
A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC...
June 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29986951/nyx-2925-is-a-novel-nmda-receptor-modulator-that-induces-rapid-and-long-lasting-analgesia-in-rat-models-of-neuropathic-pain
#6
Nayereh Ghoreishi-Haack, Jessica M Priebe, Jacqueline D Aguado, Elizabeth M Colechio, Jeffrey S Burgdorf, M Scott Bowers, Cassia N Cearley, M Amin Khan, Joseph R Moskal
NYX-2925 is a novel N-methyl-D-aspartate (NMDA) receptor modulator that is currently being investigated in Phase 2 clinical studies for the treatment of painful diabetic peripheral neuropathy and fibromyalgia. Previous studies demonstrated that NYX-2925 is a member of a novel class of NMDA receptor-specific modulators that affect synaptic plasticity processes associated with learning and memory. Studies here examined thermal and mechanical analgesic effects of NYX-2925 administration in rat peripheral chronic constriction nerve injury (CCI) and streptozotocin (STZ)-induced diabetic mechanical hypersensitivity...
July 9, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29978658/medicinal-cannabis-in-pregnancy-panacea-or-noxious-weed
#7
Mike O'Connor
The use of medicinal cannabis has been the subject of enabling legislation in Australia since 2016. At present the medical profession has not supported its use for anything but a few indications which include paediatric treatment-resistant epilepsy (especially Dravet's syndrome), pain syndromes associated with multiple sclerosis, Parkinson's disease and chemotherapy-induced nausea. However, in the United States where medicinal cannabis has been legalised in 29 States and Washington DC, nausea is an approved indication in many jurisdictions and this has been followed by widespread use for pregnancy-induced nausea and vomiting...
April 2018: Journal of Law and Medicine
https://www.readbyqxmd.com/read/29977211/multimodal-treatment-with-ect-for-identity-integration-in-a-patient-with-dissociative-identity-disorder-complex-post-traumatic-stress-disorder-and-major-depressive-disorder-a-rare-case-report
#8
Kyle D Webster, Susan Michalowski, Thomas E Hranilovich
The legitimacy and etiology of Dissociative Identity Disorder (DID) remains a controversial topic within Psychiatry. The two schools of thought are the Post-Traumatic Model (PTM) and the Socio-Cognitive Model (SCM). This case highlights the validity of PTM in an individual who suffered severe and prolonged physical, psychological, and sexual abuse from 2 years old through adulthood. The reported abuse was corroborated and proven on two separate occasions via medical professionals/rape kit and the police. This resulted in the incarceration of one of her abusers...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29973721/the-purinergic-receptor-p2rx7-directs-metabolic-fitness-of-long-lived-memory-cd8-t-cells
#9
Henrique Borges da Silva, Lalit K Beura, Haiguang Wang, Eric A Hanse, Reshma Gore, Milcah C Scott, Daniel A Walsh, Katharine E Block, Raissa Fonseca, Yan Yan, Keli L Hippen, Bruce R Blazar, David Masopust, Ameeta Kelekar, Lucy Vulchanova, Kristin A Hogquist, Stephen C Jameson
Extracellular ATP (eATP) is an ancient 'danger signal' used by eukaryotes to detect cellular damage1 . In mice and humans, the release of eATP during inflammation or injury stimulates both innate immune activation and chronic pain through the purinergic receptor P2RX72-4 . It is unclear, however, whether this pathway influences the generation of immunological memory, a hallmark of the adaptive immune system that constitutes the basis of vaccines and protective immunity against re-infection5,6 . Here we show that P2RX7 is required for the establishment, maintenance and functionality of long-lived central and tissue-resident memory CD8+ T cell populations in mice...
July 4, 2018: Nature
https://www.readbyqxmd.com/read/29964216/nociceptive-and-cognitive-changes-in-a-murine-model-of-polytrauma
#10
Peyman Sahbaie, Maral Tajerian, Phillip Yang, Karen Amanda Irvine, Ting-Ting Huang, Jian Luo, Tony Wyss-Coray, J David Clark
POLYTRAUMA COMMONLY INVOLVES CONCUSSION (MILD TRAUMATIC BRAIN INJURY: mTBI) and peripheral trauma including limb fractures. Interactions between mTBI and peripheral injuries are poorly understood, both leading to chronic pain and neurobehavioral impairments. To elucidate these interactions, a murine polytrauma model was developed. mTBI alone resulted in similar increased mechanical allodynia in males and females. Female fracture and polytrauma groups displayed greater increases in hindpaw tactile hypersensitivity for weeks after injury than respective male groups...
June 28, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29962319/acute-pain-disrupts-prospective-memory-cue-detection-processes
#11
Margarida Pitães, Chris Blais, Paul Karoly, Morris A Okun, Gene A Brewer
Prospective memory refers to the planning, retention, retrieval, and execution of intentions for future behaviours and it is integral to the enterprise of daily living. Although prospective memory relies upon retrospective memory and executive processes often disrupted by pain, limited research has explored the influence of acute or chronic pain on the ability to complete prospective memory tasks. In the present study we investigated the influence of acute pain on prospective memory tasks that varied in their demands on executive processes (i...
July 1, 2018: Memory
https://www.readbyqxmd.com/read/29961427/unusual-case-of-primary-spontaneous-hemopneumothorax-in-a-young-man-with-atypical-tension-pneumothorax-a-case-report
#12
Youwen Chen, Zhijian Guo
BACKGROUND: Spontaneous life-threatening hemopneumothorax is an atypical but treatable entity of unexpected circulatory collapse in young patients, affecting 0.5-11.6% of patients with primary spontaneous pneumothorax. Spontaneous pneumothorax is a well-documented disorder with a classic clinical presentation of acute onset chest pain and shortness of breath. This disorder might be complicated by the development of hemopneumothorax or tension pneumothorax. CASE PRESENTATION: A 23-year-old Asian man was referred to the emergency room of Xiamen Chang Gung Memorial Hospital with a 1-day history of right-sided chest pain that had been aggravated for 1 hour...
July 2, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29950886/curcumin-alleviates-pain-and-improves-cognitive-impairment-in-a-rat-model-of-cobra-venom-induced-trigeminal-neuralgia
#13
Li Zhang, Xinli Ding, Zhe Wu, Min Wang, Ming Tian
Background: Cognitive impairment is a common complication in patients with chronic neuropathic pain, without effective therapy. Recent works have indicated that curcumin (Cur) possesses antinociceptive and neuroprotective potentials, suggesting its possible effectiveness for the treatment of this complication. Objective: The aim of this study was to explore the effects of Cur on pain behaviors and cognitive impairment in rats with cobra venom-induced trigeminal neuralgia (TN)...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29941065/pain-related-distress-among-patients-referred-to-a-community-based-palliative-care-program
#14
Alexa Riggs, Brenda Breuer, Vaishali Patel, Joshua Harounian, Jack Chen, Lara Dhingra, Russell K Portenoy, Helena Knotkova
OBJECTIVE: Numerous studies have characterized the pain reported by patients with advanced illness in terms of descriptors such as severity, but few have measured pain-related distress. Distress may be important in the clinical approach to pain. To evaluate pain-related distress among adult patients with advanced illness and pain following enrollment in an urban, specialist-level, community-based palliative care program. METHOD: In a retrospective cross-sectional analysis, data were extracted from the electronic health records of all patients who were able to complete the pain item from the Condensed Memorial Symptom Assessment Scale at the start of care...
June 26, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29935586/opioid-analgesia-and-the-somatosensory-memory-of-neonatal-surgical-injury-in-the-adult-rat
#15
O Moriarty, L Harrington, S Beggs, S M Walker
BACKGROUND: Nociceptive input during early development can produce somatosensory memory that influences future pain response. Hind-paw incision during the 1st postnatal week in the rat enhances re-incision hyperalgesia in adulthood. We now evaluate its modulation by neonatal analgesia. METHODS: Neonatal rats [Postnatal Day 3 (P3)] received saline, intrathecal morphine 0.1 mg kg-1 (IT), subcutaneous morphine 1 mg kg-1 (SC), or sciatic levobupivacaine block (LA) before and after plantar hind-paw incision (three×2 hourly injections)...
July 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29929916/exploring-the-role-of-cortical-reorganization-in-postamputation-phantom-phenomena-including-phantom-limb-pain-in-lower-limb-amputees-a-cross-sectional-study-of-the-patterns-of-referral-of-sensations-into-the-phantom
#16
Cliff Richardson, Nicola Olleveant, Kath Crawford, Jai Kulkarni
Cortical reorganization and pain memory are theories to explain phantom limb pain and other postamputation phantom phenomena. This study was undertaken to identify evidence of cortical reorganization in lower limb amputees and to find evidence for the pain memory theory. This was a qualitative interview study using structured questionnaires with lower limb amputees. Participants were asked to identify body areas and activities that stimulate postamputation phantom phenomena to confirm the cortical reorganization theory...
June 18, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29925695/a-porcine-model-of-neurofibromatosis-type-1-that-mimics-the-human-disease
#17
Katherine A White, Vicki J Swier, Jacob T Cain, Jordan L Kohlmeyer, David K Meyerholz, Munir R Tanas, Johanna Uthoff, Emily Hammond, Hua Li, Frank A Rohret, Adam Goeken, Chun-Hung Chan, Mariah R Leidinger, Shaikamjad Umesalma, Margaret R Wallace, Rebecca D Dodd, Karin Panzer, Amy H Tang, Benjamin W Darbro, Aubin Moutal, Song Cai, Wennan Li, Shreya S Bellampalli, Rajesh Khanna, Christopher S Rogers, Jessica C Sieren, Dawn E Quelle, Jill M Weimer
Loss of the NF1 tumor suppressor gene causes the autosomal dominant condition, neurofibromatosis type 1 (NF1). Children and adults with NF1 suffer from pathologies including benign and malignant tumors to cognitive deficits, seizures, growth abnormalities, and peripheral neuropathies. NF1 encodes neurofibromin, a Ras-GTPase activating protein, and NF1 mutations result in hyperactivated Ras signaling in patients. Existing NF1 mutant mice mimic individual aspects of NF1, but none comprehensively models the disease...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29923456/transcription-independent-expression-of-pkm%C3%AE-in-the-anterior-cingulate-cortex-contributes-to-chronically-maintained-neuropathic-pain
#18
Hyoung-Gon Ko, Sanghyun Ye, Dae-Hee Han, Pojeong Park, Chae-Seok Lim, Kyungmin Lee, Min Zhuo, Bong-Kiun Kaang
Protein kinase M ζ is well known for its role in maintaining memory and pain. Previously, we revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role in sustaining neuropathic pain. However, the mechanism by which protein kinase M ζ is expressed in the anterior cingulate cortex by peripheral nerve injury, and whether blocking of protein kinase M ζ using its inhibitor, zeta inhibitory peptide, produces analgesic effects in neuropathic pain maintained chronically after injury, have not previously been resolved...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29913736/effects-of-the-excitatory-amino-acid-transporter-subtype-2-eaat-2-inducer-ceftriaxone-on-different-pain-modalities-in-rat
#19
Laila Eljaja, Ole J Bjerrum, Per Hartvig Honoré, Bjarke Abrahamsen
Glutamate is the major excitatory amino acid in the mammalian CNS and is involved in transmission of pain together with processes for cognition, memory and learning. In order to terminate glutamatergic neurotransmission and avoid excitotoxic damage, a balanced glutamate homeostasis is of critical importance. The level of glutamate in the synaptic cleft is regulated through the action of five subtypes of excitatory amino acid transporters (EAAT1-5). Ceftriaxone, a β-lactam, induces EAAT-2 and has proven effect for the treatment of neuropathic pain...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911576/symptoms-disabilities-and-life-satisfaction-five-years-after-whiplash-injuries
#20
Johan Styrke, Peter Sojka, Ulf Björnstig, Britt-Marie Stålnacke
Background Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain injury (MTBI)/concussion. In cases of MTBI, the severity and number of symptoms have been suggested to have a diagnostic value...
December 29, 2017: Scandinavian Journal of Pain
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