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https://www.readbyqxmd.com/read/28719507/the-relationship-between-chronic-pain-and-neurocognitive-function-a-systematic-review
#1
Diana M Higgins, Aaron M Martin, Dewleen G Baker, Jennifer J Vasterling, Victoria Risbrough
OBJECTIVE: Understanding the relationship between chronic pain and neurocognition has important implications for the assessment and treatment of pain. This paper provides an overview of the current literature examining the neurocognition-chronic pain relationship and suggests future avenues of research, along with a discussion of clinical implications of the literature findings. Consideration of potential moderators and mediators of this relationship, as well as a brief discussion of the importance of future research in special populations at particular risk for these problems, are also a focus of this paper...
July 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28711308/the-impact-of-scopolamine-pretreatment-on-3-iodothyronamine-t1am-effects-on-memory-and-pain-in-mice
#2
Annunziatina Laurino, Ersilia Lucenteforte, Gaetano De Siena, Laura Raimondi
We previously demonstrated that 3-iodothyronamine (T1AM), a by-product of thyroid hormone metabolism, pharmacologically administered to mice acutely stimulated learning and memory acquisition and provided hyperalgesia with a mechanism which remains to be defined. We now aimed to investigate whether the T1AM effect on memory and pain was maintained in mice pre-treated with scopolamine, a non-selective muscarinic antagonist expected to induce amnesia and, possibly, hyperalgesia. Mice were pre-treated with scopolamine and, after 20min, injected intracerebroventricularly (i...
July 12, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28708762/cognitive-load-selectively-influences-the-interruptive-effect-of-pain-on-attention
#3
David J Moore, Christopher Eccleston, Edmund Keogh
Pain is known to interrupt attentional performance. Such interference effects seem to occur preferentially for tasks that are complex and/or difficult. However, few studies have directly manipulated memory load in the context of pain interference to test this view. Therefore, the present study examines the effect of experimental manipulations of both memory load and pain on three tasks previously found to be sensitive to pain interference. Three experiments were conducted. A different task was examined in each experiment, each comprising of a high and low cognitive load versions of the task...
July 11, 2017: Pain
https://www.readbyqxmd.com/read/28706449/effects-of-tianeptine-on-symptoms-of-fibromyalgia-via-bdnf-signaling-in-a-fibromyalgia-animal-model
#4
Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28705181/the-impact-of-antiretroviral-therapy-on-symptom-burden-among-hiv-outpatients-with-low-cd4-count-in-rural-uganda-nested-longitudinal-cohort-study
#5
Katie Wakeham, Richard Harding, Jonathan Levin, Rosalind Parkes-Ratanshi, Anatoli Kamali, David G Lalloo
BACKGROUND: Individuals with HIV have a high prevalence of physical and psychological symptoms throughout their disease course. Despite the clinical and public health implications of unresolved pain and symptoms, little is known about the effect of anti-retroviral therapy (ART) on these outcomes. This study aimed to assess the impact on symptom burden for the year after ART initiation in individuals with a CD4 count <200 cells/uL in Uganda. METHODS: HIV-infected, ART-naıve adults referred from voluntary testing and counseling services in rural Uganda for enrollment into a randomized controlled trial to test fluconazole as primary prophylaxis against cryptococcal disease were invited to complete the Memorial Symptom Assessment Scale-Short Form (MSAS-SF) prior to commencing ART and at two subsequent follow up visits...
July 13, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28697639/forgetting-and-emotion-regulation-in-mental-health-anxiety-and-depression
#6
Simon Nørby
Does normal forgetting facilitate mental health and is forgetting impaired in affective disorders? This double-sided question may seem counterintuitive given the fact that forgetting is often associated with troubles in everyday life. However, forgetting does not only have destructive consequences, but also fulfils important functions. I consider the possibility that forgetting may function as a beneficial sorting mechanism which helps healthy people discard information that is undesirable and unpleasant. Thus, selective forgetting of negative memories may be part of emotion regulation, that is, people's attempts to control when and how they experience and express emotions...
July 12, 2017: Memory
https://www.readbyqxmd.com/read/28696624/-it-all-started-with-a-simple-symptom-and-then%C3%A2-basic-palliative-medical-tools-for-primary-care-physicians
#7
Christophe Dulong De Rosnay, Tony Tai, Olivier Pasche
The treatment of symptoms in palliative care is of primary importance, though this in itself is not sufficient for the relief of all aspects of a patient's suffering. Pain, dyspnea, or anxiety cannot be reduced to a single somatic characteristic, the psychological implications and the consequences on the patient's daily life being of paramount importance. A respect with regard to certain basic principles, and a full knowledge of the main therapeutic approaches available, allow for a better initial management of the symptoms...
November 2, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28695173/identification-of-symptom-clusters-in-cancer-patients-at-palliative-care-clinic
#8
Gülçin Şenel Özalp, Neşe Uysal, Gonca Oğuz, Nesteren Koçak, Şerife Karaca, Nihan Kadıoğulları
OBJECTIVE: Cancer patients often experience a large number of symptoms together. The aim of this study is to determine the symptom clusters in cancer patients at palliative care clinic. METHODS: Hundred and seventy consecutive patients were enrolled in the study. Memorial Symptom Assessment Scale was used for symptom assessment of the patients. RESULTS: The most experienced symptoms by the patients during the past week before hospitalization in palliative care clinic were lack of energy (95...
July 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28690001/synergistic-interaction-between-dexmedetomidine-and-ulinastatin-against-vincristine-induced-neuropathic-pain-in-rats
#9
Bilin Nie, Subo Zhang, Zhuxi Huang, Jingxiu Huang, Xiaodi Chen, Yaochao Zheng, Xiaohui Bai, Weian Zeng, Handong Ouyang
Anti-microtubulin chemotherapeutic agents such as vincristine (VCR), often induce peripheral neuropathic pain. It is usually permanent and seriously harmful to cancer patients' quality of life quality and can result in the hampering of clinical treatments. Currently, there is no definitive therapy, and many of the drugs approved for the treatment of other neuropathic pain have shown little or no analgesic effect. It is therefore vital to find new and novel therapeutic strategies for patients suffering from chemotherapeutic agent-induced neuropathic pain in order to improve patients' quality of life...
July 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28686542/polyunsaturated-fatty-acids-and-endocannabinoids-in-health-and-disease
#10
Hércules Rezende Freitas, Alinny Rosendo Isaac, Renato Malcher-Lopes, Bruno Lourenço Diaz, Isis Hara Trevenzoli, Ricardo Augusto De Melo Reis
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) synthesized from membrane phospholipids and used as a precursor for endocannabinoids (ECs). They mediate significant effects in the fine-tune adjustment of body homeostasis. Phyto- and synthetic cannabinoids also rule the daily life of billions worldwide, as they are involved in obesity, depression and drug addiction. Consequently, there is growing interest to reveal novel active compounds in this field...
July 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28681715/motor-cortex-trns-improves-pain-affective-and-cognitive-impairment-in-patients-with-fibromyalgia-preliminary-results-of-a-randomised-sham-controlled-trial
#11
Massimiliano Curatolo, Giuseppe La Bianca, Giuseppe Cosentino, Roberta Baschi, Giuseppe Salemi, Rossella Talotta, Marcello Romano, Giovanni Triolo, Marina De Tommaso, Brigida Fierro, Filippo Brighina
OBJECTIVES: Fibromyalgia (FM) is a clinical syndrome characterised by widespread musculoskeletal pain, chronic fatigue, cognitive deficits, and sleep and mood disorders. The effectiveness of most pharmacological treatments is limited, and there is a need for new, effective and well-tolerated therapies. It has recently been shown that transcranial direct-current stimulation (tDCS) of the motor cortex reduces pain, and that tDCS of the dorso-lateral prefrontal cortex (DLPFC) improves anxiety, depression and cognitive impairment in FM patients...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28677012/persistent-impairments-3%C3%A2-years-after-neo-adjuvant-chemotherapy-for-breast-cancer-results-from-the-matox-project
#12
Hans-Jürgen Hurtz, Hans Tesch, Thomas Göhler, Ulrich Hutzschenreuter, Johanna Harde, Lisa Kruggel, Martina Jänicke, Norbert Marschner
PURPOSE: Although treatment for early breast cancer improved prognosis greatly, it can have significant long-term consequences, which must be considered during treatment decision. METHODS: 453 patients with neoadjuvant or adjuvant treatment intention were recruited into the MaTox project within the prospective, multicentre, population-based German TMK cohort study (Tumour Registry Breast Cancer) between 2008 and 2009. Patient-reported outcomes (PROs) on 26 treatment-related symptoms were assessed via a specifically designed questionnaire at 4 weeks, 6 months, 18 months and 3 years after start of systemic treatment...
July 5, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28674390/empathy-skill-dependent-modulation-of-working-memory-by-painful-scene
#13
Mo Chen, Yuan-Zheng Wang, Chen-Chen Ma, Qi-Ze Li, Han Zhou, Jie Fu, Qian-Qian Yang, Yong-Mei Zhang, Yu Liu, Jun-Li Cao
As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or emotions, regulate the human working memory ability is not well explored. Here we investigated the influences of empathic pain on upcoming working memory and existing working memory, by presenting human subjects with the pictures depicting painful or neutral scene...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28670707/radiosynthesis-and-evaluation-of-1-substituted-3-2-3-dihydro-1h-inden-2-yl-6-1-ethylpropyl-3r-6r-2-5-piperazinedione-derivatives-as-pet-tracers-for-imaging-the-central-oxytocinergic-system
#14
Carmine Marzano, Steen Jacobsen, Cristian Salinas, Sac Pham Tang, Dirk Bender, Jan Passchier, Christophe Plisson
Oxytocin is known to be implicated in a variety of functions, such as learning, stress, anxiety, feeding and pain perception. Oxytocin is also important for social memory and attachment, human bonding, sexual and maternal behaviour, and aggression. Human disorders characterized by aberrant social interactions, such as autism and schizophrenia, may also involve abnormal oxytocin levels. GSK712043, GSK711320 and GSK664004, three antagonists exhibiting sub-nanomolar affinity for the human oxytocin receptor (hOTR) and high selectivity over vasopressin receptors were successfully labelled with carbon-11 with suitable yields (0...
July 3, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28663110/sucrose-and-naltrexone-prevent-increased-pain-sensitivity-and-impaired-long-term-memory-induced-by-repetitive-neonatal-noxious-stimulation-role-of-bdnf-and-%C3%AE-endorphin
#15
Khawla Q Nuseir, Karem H Alzoubi, Ahmed Alhusban, Areej Bawaane, Mohammed Al-Azzani, Omar F Khabour
Pain in neonates is associated with short and long-term adverse outcomes. Data demonstrated that long-term consequences of untreated pain are linked to the plasticity of the neonate's brain. Sucrose is effective and safe for reducing painful procedures from single events. However, the mechanism of sucrose-induced analgesia is not fully understood. The role of the opioid system in this analgesia using the opioid receptor antagonist Naltrexone was investigated, plus the long-term effects on learning and memory formation during adulthood...
June 27, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28663003/postoperative-radiotherapy-after-dcis-useful-for-whom
#16
Per Karlsson
The number of patients with ductal carcinoma in situ (DCIS) increases with more widely used screening mammography programs. DCIS accounts for approximately 20% of all new breast cancer diagnoses in these programs and the natural course of this heterogeneous group of pre-invasive lesions is not fully known. Better definition of subgroups benefitting from radiotherapy and knowledge on the natural course of DCIS are important issues for the future management of DCIS. Four large randomized trials have studied the effects of postoperative radiotherapy after breast conserving surgery in patients with wider spectrum of DCIS and all of them have shown radiotherapy to halve the risk of ipsilateral events, however, without any significant effect on breast cancer mortality...
June 26, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28662189/affective-and-cognitive-behavior-in-the-alpha-galactosidase-a-deficient-mouse-model-of-fabry-disease
#17
Lukas Hofmann, Franziska Karl, Claudia Sommer, Nurcan Üçeyler
Fabry disease is an X-linked inherited lysosomal storage disorder with intracellular accumulation of globotriaosylceramide (Gb3) due to α-galactosidase A (α-Gal A) deficiency. Fabry patients frequently report of anxiety, depression, and impaired cognitive function. We characterized affective and cognitive phenotype of male mice with α-Gal A deficiency (Fabry KO) and compared results with those of age-matched male wildtype (WT) littermates. Young (3 months) and old (≥ 18 months) mice were tested in the naïve state and after i...
2017: PloS One
https://www.readbyqxmd.com/read/28659771/cognitive-impairment-in-patients-with-chronic-neuropathic-or-radicular-pain-an-interaction-of-pain-and-age
#18
Orla Moriarty, Nancy Ruane, David O'Gorman, Chris H Maharaj, Caroline Mitchell, Kiran M Sarma, David P Finn, Brian E McGuire
A growing body of empirical research has confirmed an association between chronic pain and cognitive dysfunction. The aim of the present study was to determine whether cognitive function is affected in patients with a diagnosis of chronic neuropathic or radicular pain relative to healthy control participants matched by age, gender, and years of education. We also examined the interaction of pain with age in terms of cognitive performance. Some limitations of previous clinical research investigating the effects of chronic pain on cognitive function include differences in the pain and cognitive scale materials used, and the heterogeneity of patient participants, both in terms of their demographics and pathological conditions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28657811/description-of-the-case-mix-experienced-by-chiropractic-students-during-a-clinical-internship
#19
Aaron A Puhl, Christine J Reinhart, H Stephen Injeyan, Anthony Tibbles
OBJECTIVE: The primary objective of this study was to describe the case mix experienced by chiropractic students during their clinical internship at the Canadian Memorial Chiropractic College. Secondary objectives were to characterize teaching clinic patient populations, assess the similarity to previously published data for practicing chiropractors, and describe the treatment plans being recommended by interns. METHODS: A prospective, observational study was conducted using a convenience sample of 24 chiropractic interns...
June 28, 2017: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/28648984/whole-body-biodistribution-of-the-cannabinoid-type-1-receptor-ligand-18-f-mk-9470-in-the-rat
#20
H G Buchholz, K Uebbing, S Maus, S Pektor, N Afahaene, V Weyer-Elberich, B Lutz, M Schreckenberger, I Miederer
The endocannabinoid system participates in many processes in the body, including memory, reward, pain, motor activity, food intake, energy metabolism, and gastrointestinal functions. [(18)F]MK-9470 is a positron emission tomography (PET) ligand that binds with high affinity and selectivity to the cannabinoid type 1 receptor. In order to fully characterize ligand behavior, tracer uptake measured using in vivo microPET was compared with results from ex vivo tissue dissection. Twelve male Sprague-Dawley rats were divided into three subgroups and scanned over time periods of 10min, 30min and 90min using PET...
June 15, 2017: Nuclear Medicine and Biology
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