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Hepatobilliary cancer

Matthias Bauwens, Marijke De Saint-Hubert, Ellen Devos, Niko Deckers, Chris Reutelingsperger, Luc Mortelmans, Uwe Himmelreich, Felix M Mottaghy, Alfons Verbruggen
PURPOSE: Two variants of Annexin A5 (Cys2-AnxA5 and Cys165-AnxA5) were labelled with Gallium-68 in order to evaluate their biological properties. PROCEDURES: Biodistribution and pharmacokinetics of the radiotracers were studied with μPET in healthy mice and in a mouse model of hepatic apoptosis. μPET imaging after IV injection of the tracers in combination with μMRI was performed in Daudi tumor bearing mice before and after treatment with a combination of chemotherapy and radiotherapy...
April 2011: Nuclear Medicine and Biology
Sungmin Baek, Yong-Whan Lee, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Sae-Ock Oh
Intrahepatic cholangiocarcinoma is the second most common subtype of primary hepatobilliary cancer. Despite advances in surgical and medical therapy, its survival rate remains poor. Compared to hepatocellular carcinoma (HCC), the most common liver malignancy, the underlying mechanisms of cholangiocarcinoma carcinogenesis are poorly characterized. P-cadherin (CDH3) is a cadherin super family member. Although CDH3 is frequently over-expressed in cholangiocarcinoma tissues, its roles have never been characterized...
June 2010: Anatomy & Cell Biology
S Fujimoto, M Asaka
The recent phenomenal success of laparoscopic cholecystectomy has led to replacement of conventional abdominal surgery as the standard treatment of gall bladder diseases. In an enterprising attempt to expand clinical indications for this minimally invasive form of surgery, physicians and surgeons of the various specialties have been looking to endoscopic operations for benign and/or malignant diseases. Endoscopic surgery usually combines the advantages of less postoperative pains and early return to routine activities with clinical efficacy equivalent to the conventional operation whenever its indication is right...
May 1995: [Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
K Yamaguchi, S Fujimoto, F Misaki, K Kawai
Using the simple thin layer polyacrylamide gel electrophoresis, serum alkaline phosphatase could be separated 5 isozyme bands in various digestive diseases, consisting of 54 cases of gastric cancer, 11 of colonic cancer, 12 of hepatoma, 4 of cholangioma, 14 of pancreatic cancer, 81 of benign hepatobilliary diseases, 13 of cancers of other organs and 61 of control. The obtained results were as follows: 1) The electrophoretic analysis of serum alkaline phosphatase showed the specific band remaining at the origin, already reported as "alkaline phosphatase O", in primary and metastatic cancer of the liver and cholelithiasis...
1978: Gastroenterologia Japonica
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