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https://www.readbyqxmd.com/read/28548701/microtubules-regulate-brush-border-formation
#1
Facundo M Tonucci, Anabela Ferretti, Evangelina Almada, Pamela Cribb, Rodrigo Vena, Florencia Hidalgo, Cristián Favre, Matt J Tyska, Irina Kaverina, M Cecilia Larocca
Most epithelial cells contain apical membrane structures associated to bundles of actin filaments, which constitute the brush border. Whereas microtubule participation in the maintenance of the brush border identity has been characterized, their contribution to de novo microvilli organization remained elusive. Hereby, using a cell model of individual enterocyte polarization, we found that nocodazole induced microtubule depolymerization prevented the de novo brush border formation. Microtubule participation in brush border actin organization was confirmed in polarized kidney tubule MDCK cells...
May 26, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28548099/conformational-dynamics-of-dynamin-like-mxa-revealed-by-single-molecule-fret
#2
Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao, Song Gao
Human myxovirus resistance protein 1 (MxA) restricts a wide range of viruses and is closely related to the membrane-remodelling GTPase dynamin. The functions of MxA rely on domain rearrangements coupled with GTP hydrolysis cycles. To gain insight into this process, we studied real-time domain dynamics of MxA by single-molecule fluorescence resonance energy transfer. We find that the GTPase domain-bundle-signalling-element (BSE) region can adopt either an 'open' or a 'closed' conformation in all nucleotide-loading conditions...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28546456/electrocardiographic-predictors-of-heart-failure-with-reduced-versus-preserved-ejection-fraction-the-multi-ethnic-study-of-atherosclerosis
#3
Wesley T O'Neal, Matylda Mazur, Alain G Bertoni, David A Bluemke, Mouaz H Al-Mallah, Joao A C Lima, Dalane Kitzman, Elsayed Z Soliman
BACKGROUND: Several markers detected on the routine 12-lead ECG are associated with future heart failure events. We examined whether these markers are able to separate the risk of heart failure with reduced ejection fraction (HFrEF) from heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We analyzed data of 6664 participants (53% female; mean age 62±10 years) from MESA (Multi-Ethnic Study of Atherosclerosis) who were free of cardiovascular disease at baseline (2000-2002)...
May 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28545852/duration-of-reverse-remodeling-response-to-cardiac-resynchronization-therapy-rates-predictors-and-clinical-outcomes
#4
Takafumi Oka, Koichi Inoue, Koji Tanaka, Yuko Toyoshima, Takaaki Isshiki, Takeshi Kimura, Masakiyo Nobuyoshi, Satoshi Shizuta, Takeshi Arita, Satoki Fujii, Katsuomi Iwakura, Kenshi Fujii, Kenji Ando
BACKGROUND: A subset of patients undergoing cardiac resynchronization therapy (CRT) for heart failure (HF) with severe left ventricular (LV) dysfunction experience only short-lived LV reverse remodeling. Little is known about the incidence and prognosis of this finding. We sought to identify predictors of a brief response and investigated the prognosis in a retrospective study. METHODS: A total of 528 patients from a Japanese multicenter database with full echocardiography datasets were enrolled...
May 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28545837/emerging-technologies-for-prediction-of-drug-candidate-efficacy-in-the-preclinical-pipeline
#5
Denis Menshykau
The pharmaceutical industry is tackling increasingly complex multifactorial diseases, resulting in increases in research & development (R&D) costs and reductions in the success rates for drug candidates during Phase 2 and 3 clinical trials, with a lack of efficacy being the primary reason for drug candidate failure. This implies that the predictive power of current preclinical assays for drug candidate efficacy is suboptimal and, therefore, that alternatives should be developed. Here, I review emerging in vitro, imaging, and in silico technologies and discuss their potential contribution to drug efficacy assessment...
May 22, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28545626/very-late-continued-reverse-remodelling-after-cardiac-resynchronization-therapy-in-patients-with-extreme-left-ventricular-dilatation
#6
Samuel Larue-Grondin, François Philippon, Jean-François Sarrazin, Sacha-Michelle Dubois-Sénéchal, Michelle Dubois, Mario Sénéchal
Response to cardiac resynchronization therapy (CRT) varies greatly among patients. We present 2 patients with severe heart failure symptoms (New York Heart Association class IV) and extreme initial left ventricular (LV) dilatation (LV end-diastolic diameter of 92 mm and 80 mm, respectively) and severe functional mitral regurgitation who underwent CRT device implantation. Long-term follow-up showed late (≥ 4 years) normalization of LV ejection fraction (LVEF), LV dimensions, and functional status. In a subgroup of patients with nonischemic dilated cardiomyopathy and complete left bundle branch block, late continued LV reverse remodelling may lead to normalization of LV volumes and LVEF and significant improvement in functional class...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545591/an-ultrastructural-study-of-the-surface-and-attachment-structures-of-paradiplozoon-homoion-bychowsky-nagibina-1959-monogenea-diplozoidae
#7
Veronika Konstanzová, Božena Koubková, Martin Kašný, Jana Ilgová, Ewa Dzika, Milan Gelnar
BACKGROUND: Species of Diplozoon Palombi, 1949 (Monogenea: Diplozoidae) are blood-feeding ectoparasites mainly parasitising the gills of cyprinid fishes. Although these parasites have been the subject of numerous taxonomic, phylogenetic and ecological studies, the ultrastructure of the surface and haptor attachment structures remains almost unknown. In this study, we used transmission electron microscopy to examine the ultrastructure of attachment clamps and neodermal surface of Paradiplozoon homoion (Bychowsky & Nagibina, 1959), family Diplozoidae Palombi, 1949, thereby broadening our knowledge of platyhelminth biology...
May 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28545516/improving-the-regenerative-potential-of-olfactory-ensheathing-cells-by-overexpressing-prostacyclin-synthetase-and-its-application-in-spinal-cord-repair
#8
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng
BACKGROUND: Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears to facilitate axonal regeneration although the functional recovery is limited. In an attempt to improve the growth-promoting properties of OEC, we transduced prostacyclin synthase (PGIS) to OEC via adenoviral (Ad) gene transfer and examined the effect of OEC with enhanced prostacyclin synthesis in co-culture and in vivo...
May 25, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28545281/-pre-and-post-orthotopic-heart-transplantation-electrocardiogram-characteristics-of-998-patients
#9
H Q Guan, Z J Chen, Y Zhou, J Liu, W X Sun, J Yuan, Y H Liao, N G Dong, J P Liu, K G Feng, Q Zhang, X Zhao, C Qian, F Hu
Objective: To analyze pre- and post-operation electrocardiograms (ECGs) features of patients underwent orthotopic heart transplantation (OHT), and provide evidences for identifying and analyzing post OHT ECGs. Methods: Nine hundreds and ninty-eight pre- and post- OHT standard 12-leads ECGs from 110 consecutive patients, who underwent OHT in our hospital from May 2008 to May 2014, were analyzed. Results: The mean heart rate(HR)was (86.9±16.4) beats per minute before OHT, and (100.0±0.4) beats per minute after OHT...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28544434/strain-stiffening-hydrogels-through-self-assembly-and-covalent-fixation-of-semi-flexible-fibers
#10
Rint P Sijbesma, Marcos Fernandez-Castano Romera, Clément Guibert, Ilja K Voets, Cornelis Storm
Biomimetic, strain-stiffening materials are reported, made through self-assembly and covalent fixation of small building blocks to form fibrous hydrogels able to stiffen by an order of magnitude in response to applied stress. The gels consist of semi-flexible rodlike micelles of bisurea bolaamphiphiles with oligo(ethylene oxide) (EO) outer blocks and a polydiacetylene (PDA) backbone. The micelles are fibers composed of 9-10 ribbons. A gelation method based on Cu-catalyzed azide-alkyne cycloaddition (CuAAC) was developed that leads to strain-stiffening hydrogels with unusual yet universal linear and nonlinear stress-strain response...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543996/self-assembly-of-perylenediimide-single-strand-dna-conjugates-employing-hydrophobic-interactions-and-dna-base-pairing-to-create-a-diverse-structural-space
#11
Frederick Lewis, Ashutosh Kumar Mishra, Haim Weissman, Elisha Krieg, Kevin A Voltaw, Martin McCullagh, Boris Rybtchiinski
The self-assembly behavior of DNA conjugates possessing a perylenediimide (PDI) head group and a single N-oligonucleotide tail has been investigated using a combination of optical spectroscopy and cryogenic transmission electron microscopy (cryo-TEM) imaging. In order to obtain insight into the interplay between DNA base pairing and PDI hydrophobic interactions we employed systematic variation in the length and composition of the oligo tails. Conjugates with short (TA)n or (CG)n oligo tails (n ≤ 3) form fibers (helical or nonhelical) constructed from -stacked PDI head groups with pendent oligo tails at room temperature in aqueous solution...
May 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543843/white-matter-biomarkers-from-fast-protocols-using-axially-symmetric-diffusion-kurtosis-imaging
#12
Brian Hansen, Ahmad R Khan, Noam Shemesh, Torben E Lund, Ryan Sangill, Simon F Eskildsen, Leif Østergaard, Sune N Jespersen
White matter tract integrity (WMTI) can characterize brain microstructure in areas with highly aligned fiber bundles. Several WMTI biomarkers have now been validated against microscopy and provided promising results in studies of brain development and aging, as well as in a number of brain disorders. Currently, WMTI is mostly used in dedicated animal studies and clinical studies of slowly progressing diseases, and has not yet emerged as a routine clinical tool. To this end, a less data intensive experimental method would be beneficial by enabling high resolution validation studies, and ease clinical applications by speeding up data acquisition compared with typical diffusion kurtosis imaging (DKI) protocols utilized as part of WMTI imaging...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543795/permanent-nonselective-his-bundle-pacing-in-an-adult-with-l-transposition-of-the-great-arteries-and-complete-av-block
#13
Adam C Kean, W Aaron Kay, Jyoti K Patel, John M Miller, Gopi Dandamudi
We report the placement of a permanent transvenous nonselective His bundle pacing lead in conjunction with a transvenous pacemaker/ICD in an adult with Levo-Transposition of the Great Arteries (L-TGA) and a stenotic coronary sinus (CS) ostium (os), which would not accommodate a transvenous LV pacing lead. Nonselective His bundle pacing provided a nearly identical ventricular activation pattern in this previously unpaced patient. Many L-TGA patients will have an eventual need for permanent pacing and, given the challenges of CS cannulation, His bundle pacing may represent a preferred modality rather than pure morphologic LV pacing or surgical systemic ventricular lead placement to achieve optimal electrical synchrony...
May 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28543265/stricter-criteria-for-left-bundle-branch-block-diagnosis-do-not-improve-response-to-crt
#14
Emanuele Bertaglia, Federico Migliore, Anna Baritussio, Antonio De Simone, Albino Reggiani, Domenico Pecora, Antonio D'Onofrio, Antonio Rapacciuolo, Gianluca Savarese, Attilio Pierantozzi, Biondino Marenna, Franco Ruffa, Monica Campari, Maurizio Malacrida, Giuseppe Stabile
BACKGROUND: Cardiac resynchronization therapy (CRT) has proved to be effective in patients with heart failure and left bundle branch block (LBBB). Recently, new ECG criteria have been proposed for the diagnosis of LBBB. These criteria are stricter than the current American Heart Association (AHA) criteria. We assessed the rate of echocardiographic response to CRT in patients with traditional LBBB versus patients who met the new criteria (strict LBBB). METHODS: Consecutive patients undergoing CRT were enrolled in the CRT MORE registry...
May 23, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28541797/the-effect-of-intraoperative-graft-coverage-with-preserved-remnant-tissue-on-the-results-of-the-pivot-shift-test-after-anatomic-double-bundle-anterior-cruciate-ligament-reconstruction-quantitative-evaluations-with-an-electromagnetic-sensor-system
#15
Nobuto Kitamura, Kazunori Yasuda, Masashi Yokota, Keiko Goto, Susumu Wada, Jun Onodera, Eiji Kondo
BACKGROUND: Remnant tissue preservation may be important in improving graft healing after anterior cruciate ligament (ACL) reconstruction, but it has yet to be established whether remnant tissue preservation improves the control of pivot-shift laxity. HYPOTHESIS: The amount of ACL graft coverage with preserved remnant tissue improves the control of pivot-shift laxity, as qualitatively determined with an electromagnetic device. STUDY DESIGN: Cohort study; Level of evidence, 3...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28540619/medial-collateral-ligament-reconstruction-is-necessary-to-restore-anterior-stability-with-anterior-cruciate-and-medial-collateral-ligament-injury
#16
Junjun Zhu, Jiangtao Dong, Brandon Marshall, Monica A Linde, Patrick Smolinski, Freddie H Fu
PURPOSE: The purpose of this study was to compare knee kinematics and graft forces in anterior cruciate ligament (ACL) reconstruction combined with one of two superficial medial collateral ligament (sMCL) reconstruction techniques (parallel or triangular vector sMCL reconstruction). METHODS: Twenty porcine knees were divided into two groups (n = 20), parallel or triangular vector sMCL reconstruction, with both groups having anatomic single-bundle ACL reconstruction...
May 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28540527/alignment-of-inducible-vascular-progenitor-cells-on-a-micro-bundle-scaffold-improves-cardiac-repair-following-myocardial-infarction
#17
Anurag Jamaiyar, Weiguo Wan, Vahagn Ohanyan, Molly Enrick, Danielle Janota, Devan Cumpston, Hokyung Song, Kelly Stevanov, Christopher L Kolz, Tatev Hakobyan, Feng Dong, Bi-Min Zhang Newby, William M Chilian, Liya Yin
Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has great potential for cardiovascular regeneration, the ideal cell type and delivery method of cells have not been resolved. We tested a new approach of stem cell therapy by delivery of induced vascular progenitor cells (iVPCs) grown on polymer micro-bundle scaffolds in a rat model of myocardial infarction...
July 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28540116/using-care-bundles-to-improve-surgical-outcomes-and-reduce-variation-in-care-for-fragility-hip-fracture-patients
#18
Stephanie Bandara, Genni Lynch, Cameron Cooke, Paul Varghese, Nicola Ward
INTRODUCTION: Fragility hip fractures constitute a large proportion of orthogeriatric admissions to orthopedic wards. This study looked at reducing variation in care in fragility hip fracture patients using a novel approach with care bundles. The care bundle comprises 5 elements targeted at providing adequate analgesia, early mobilization, improving recognition of delirium, and decreasing rates of urinary infections. METHODS: A total of 198 patients who sustained a fragility hip fracture during the intervention period were included in the study...
June 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28539049/assembly-of-huntingtin-headpiece-into-%C3%AE-helical-bundles
#19
Beytullah Ozgur, Mehmet Sayar
Protein aggregation is a hallmark of neurodegenerative disorders. In this group of brain-related disorders, a disease-specific "host" protein or fragment misfolds and adopts a metastatic, aggregate-prone conformation. Often, this misfolded conformation is structurally and thermodynamically different from its native state. Intermolecular contacts, which arise in this non-native state, promote aggregation. In this regard, understanding the molecular principles and mechanisms that lead to the formation of such a non-native state and further promote the formation of the critical nucleus for fiber growth is essential...
May 24, 2017: Biointerphases
https://www.readbyqxmd.com/read/28538886/cutaneous-angiosarcoma-report-of-three-different-and-typical-cases-admitted-in-a-unique-dermatology-clinic
#20
Aline Neves Freitas Cabral, Rafael Henrique Rocha, Ana Cristina Vervloet do Amaral, Karina Bittencourt Medeiros, Paulo Sérgio Emerich Nogueira, Lucia Martins Diniz
Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast...
March 2017: Anais Brasileiros de Dermatologia
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