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https://www.readbyqxmd.com/read/29352699/computed-tomography-ct-assessment-of-the-membranous-septal-anatomy-prior-to-transcatheter-aortic-valve-replacement-tavr-with-the-balloon-expandable-sapien-3-valve
#1
Brett A Oestreich, Mackenzie Mbai, Sergey Gurevich, Prabhjot S Nijjar, Selcuk Adabag, Stefan Bertog, Rosemary Kelly, Santiago Garcia
OBJECTIVES: The lower limit of the membranous septum (MS) is considered an anatomic landmark for the emergence of the Bundle of His into the left ventricle. Computed tomography (CT) assessment of MS anatomy may provide useful information about the risk of conduction abnormalities following transcatheter aortic valve replacement (TAVR). METHODS AND RESULTS: The study included 102 consecutive patients undergoing TAVR with the Edwards Sapien 3 (S3) valve. Using pre-TAVR CT and post-procedure angiography we evaluated for the presence of calcium in the left ventricular outflow tract (LVOT), calcium depth (CD), implantation depth (ID) and MS length...
December 27, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29352239/elucidating-the-mechanism-of-the-considerable-mechanical-stiffening-of-dna-induced-by-the-couple-zn2-calix-4-arene-1-3-o-diphosphorous-acid
#2
Yannick Tauran, Mehmet C Tarhan, Laurent Mollet, Jean Baptiste Gerves, Momoko Kumemura, Laurent Jalabert, Nicolas Lafitte, Ikjoo Byun, Beomjoon Kim, Hiroyuki Fujita, Dominique Collard, Florent Perret, Mickael Desbrosses, Didier Leonard, Christelle Goutaudier, Anthony W Coleman
The couple Calix[4]arene-1,3-O-diphosphorous acid (C4diP) and zinc ions (Zn2+) acts as a synergistic DNA binder. Silicon NanoTweezer (SNT) measurements show an increase in the mechanical stiffness of DNA bundles by a factor of >150, at Zn2+ to C4diP ratios above 8, as compared to Zinc alone whereas C4diP alone decreases the stiffness of DNA. Electroanalytical measurements using 3D printed devices demonstrate a progression of events in the assembly of C4diP on DNA promoted by zinc ions. A mechanism at the molecular level can be deduced in which C4diP initially coordinates to DNA by phosphate-phosphate hydrogen bonds or in the presence of Zn2+ by Zn2+ bridging coordination of the phosphate groups...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352227/ly2087101-and-dfbr-share-transmembrane-binding-sites-in-the-%C3%AE-4-3-%C3%AE-2-2-nicotinic-acetylcholine-receptor
#3
Farah Deba, Hamed I Ali, Abisola Tairu, Kara Ramos, Jihad Ali, Ayman K Hamouda
Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have potential therapeutic application in neuropathologies associated with decrease in function or loss of nAChRs. In this study, we characterize the pharmacological interactions of the nAChRs PAM, LY2087101, with the α4β2 nAChR using mutational and computational analyses. LY2087101 potentiated ACh-induced currents of low-sensitivity (α4)3(β2)2 and high-sensitivity (α4)2(β2)3 nAChRs with similar potencies albeit to a different maximum potentiation (potentiation I max  = ~840 and 450%, respectively)...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351870/de-novo-generation-in-an-in-vivo-rat-model-and-biomechanical-characterization-of-autologous-transplants-for-ligament-and-tendon-reconstruction
#4
Marc Soubeyrand, Elisabeth Laemmel, Nathalie Maurel, Amadou Diop, Thierry Lazure, Jacques Duranteau, Eric Vicaut
BACKGROUND: Surgical reconstruction of ligaments and tendons is frequently required in clinical practice. The commonly used autografts, allografts, or synthetic transplants present limitations in terms of availability, biocompatibility, cost, and mechanical properties that tissue bioengineering aims to overcome. It classically combines an exogenous extracellular matrix with cells, but this approach remains complex and expensive. Using a rat model, we tested a new bioengineering strategy for the in vivo and de novo generation of autologous grafts without the addition of extracellular matrix or cells, and analyzed their biomechanical and structural properties...
December 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29351276/static-length-changes-of-cochlear-outer-hair-cells-can-tune-low-frequency-hearing
#5
Nikola Ciganović, Rebecca L Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias Reichenbach
The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce the resulting motion into electric signals that propagate via the auditory nerve to the brain. However, how the outer hair cells modulate the stimulus to the inner hair cells remains unclear. Here, we combine theoretical modeling and experimental measurements near the cochlear apex to study the way in which length changes of the outer hair cells deform the organ of Corti...
January 19, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29351145/recent-evidence-on-early-mobilization-in-critical-ill-patients
#6
Kristina Fuest, Stefan J Schaller
PURPOSE OF REVIEW: To examine the benefits of early mobilization and summarize the results of most recent clinical studies examining early mobilization in critically ill patients followed by a presentation of recent developments in the field. RECENT FINDINGS: Early mobilization of ICU patients, defined as mobilization within 72 h of ICU admission, is still uncommon. In medical and surgical critically ill patients, mobilization is well tolerated even in intubated patients...
January 17, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29350628/inkjet-printing-and-electrical-characterisation-of-dna-templated-cadmium-sulfide-nanowires
#7
Raushan Nurdillayeva, Atsinafe Oshido, Thomas Bamford, Osama El-Zubir, Andrew Houlton, John Hedley, Andrew Pike, Benjamin Horrocks
Cadmium sulfide can be templated on -DNA molecules to form an aqueous dispersion of CdS/-DNA nanowires. Subsequent addition of ethylene glycol to 50% v/v is sufficient to formulate an ink suitable for printing using piezoelectric drop-on-demand technology. Printed droplet arrays show a coffee-ring morphology of individual deposits by fluorescence and Raman microscopy, but upon increasing the number of layers of printed material by repeated printing over each droplet, the dry deposit approaches closer to a disc shape...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29350222/a-prescription-for-note-bloat-an-effective-progress-note-template
#8
Daniel Khan, Elizabeth Stewart, Mark Duncan, Edward Lee, Wendy Simon, Clement Lee, Jodi Friedman, Hilary Mosher, Katherine Harris, John Bell, Bradley Sharpe, Neveen El-Farra
BACKGROUND: United States hospitals have widely adopted electronic health records (EHRs). Despite the potential for EHRs to increase efficiency, there is concern that documentation quality has suffered. OBJECTIVE: To examine the impact of an educational session bundled with a progress note template on note quality, length, and timeliness. DESIGN: A multicenter, nonrandomized prospective trial. SETTING: Four academic hospitals across the United States...
January 19, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29349559/a-mutant-hcn4-channel-in-a-family-with-bradycardia-left-bundle-branch-block-and-left-ventricular-noncompaction
#9
Ryosuke Yokoyama, Koshi Kinoshita, Yukiko Hata, Masayoshi Abe, Kenta Matsuoka, Keiichi Hirono, Masanobu Kano, Makoto Nakazawa, Fukiko Ichida, Naoki Nishida, Toshihide Tabata
We found that a female infant presenting with left bundle branch block and left ventricular noncompaction carries uninvestigated gene mutations HCN4(G811E), SCN5A(L1988R), DMD(S2384Y), and EMD(R203H). Here, we explored the possible pathogenicity of HCN4(G811E), which results in a G811E substitution in hyperpolarization-activated cyclic nucleotide-gated channel 4, the main subunit of the cardiac pacemaker channel. Voltage-clamp measurements in a heterologous expression system of HEK293T cells showed that HCN4(G811E) slightly reduced whole-cell HCN4 channel conductance, whereas it did not affect the gating kinetics, unitary conductance, or cAMP-dependent modulation of voltage-dependence...
January 18, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29349539/effect-of-the-application-of-a-bundle-of-three-measures-intraperitoneal-lavage-with-antibiotic-solution-fascial-closure-with-triclosan-coated-sutures-and-mupirocin-ointment-application-on-the-skin-staples-on-the-surgical-site-infection-after-elective-laparoscopic
#10
Jaime Ruiz-Tovar, Carolina Llavero, Vicente Morales, Carlos Gamallo
BACKGROUND: Surgical site infection (SSI) prevention bundles include the simultaneous use of different measures, which individually have demonstrated an effect on prevention of SSI. The implementation of bundles can yield superior results to the implementation of individual measures. The aim of this study was to address the effect of the application of a bundle including intraperitoneal lavage with antibiotic solution, fascial closure with Triclosan-coated sutures and Mupirocin ointment application on the skin staples, on the surgical site infection after elective laparoscopic colorectal cancer surgery...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29349007/anterior-cruciate-ligament-primary-repair-with-independent-tensioning-of-the-anteromedial-and-posterolateral-bundles
#11
Patrick A Smith, Jordan A Bley
This procedure represents an update on traditional primary repair methods by taking advantage of technological advancements to optimize soft tissue fixation and allow for an anatomic double-bundle primary repair with independent bundle tensioning and an internal brace construct to restore normal anterior cruciate ligament biomechanics.
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348205/structure-of-the-fission-yeast-actomyosin-ring-during-constriction
#12
Matthew T Swulius, Lam T Nguyen, Mark S Ladinsky, Davi R Ortega, Samya Aich, Mithilesh Mishra, Grant J Jensen
Cell division in many eukaryotes is driven by a ring containing actin and myosin. While much is known about the main proteins involved, the precise arrangement of actin filaments within the contractile machinery, and how force is transmitted to the membrane, remains unclear. Here we use cryosectioning and cryofocused ion beam milling to gain access to cryopreserved actomyosin rings in Schizosaccharomyces pombe for direct 3D imaging by electron cryotomography. Our results show that straight, overlapping actin filaments, running nearly parallel to each other and to the membrane, form a loose bundle of ∼150 nm in diameter that "saddles" the inward-bending membrane at the leading edge of the division septum...
January 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29348024/cardiomyopathy-and-left%C3%A2-bundle%C3%A2-branch%C3%A2-block-a-farewell-to-drugs
#13
EDITORIAL
Cecilia Linde, Frieder Braunschweig
No abstract text is available yet for this article.
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29348023/impaired-recovery-of-left-ventricular-function-in-patients-with-cardiomyopathy-and-left%C3%A2-bundle-branch-block
#14
Edward Sze, Zainab Samad, Allison Dunning, Kristen Bova Campbell, Zak Loring, Brett D Atwater, Karen Chiswell, Joseph A Kisslo, Eric J Velazquez, James P Daubert
BACKGROUND: Patients with left bundle branch block (LBBB) often respond to cardiac resynchronization therapy (CRT) with left ventricular ejection fraction (LVEF) improvement. Guideline-directed medical therapy (GDMT), not CRT, is first-line therapy for patients with reduced LVEF with LBBB. However, there are little data on how patients with reduced LVEF and LBBB respond to GDMT. OBJECTIVES: This study examined patients with cardiomyopathy and sought to assess rates of LVEF improvement for patients with LBBB compared to other QRS morphologies...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29347952/the-german-quality-network-sepsis-study-protocol-for-the-evaluation-of-a-quality-collaborative-on-decreasing-sepsis-related-mortality-in-a-quasi-experimental-difference-in-differences-design
#15
Daniel Schwarzkopf, Hendrik Rüddel, Matthias Gründling, Christian Putensen, Konrad Reinhart
BACKGROUND: While sepsis-related mortality decreased substantially in other developed countries, mortality of severe sepsis remained as high as 44% in Germany. A recent German cluster randomized trial was not able to improve guideline adherence and decrease sepsis-related mortality within the participating hospitals, partly based on lacking support by hospital management and lacking resources for documentation of prospective data. Thus, more pragmatic approaches are needed to improve quality of sepsis care in Germany...
January 18, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29347908/management-and-outcomes-of-patients-presenting-with-sepsis-and-septic-shock-to-the-emergency-department-during-nursing-handover-a-retrospective-cohort-study
#16
Sami Alsolamy, Atheer Al-Sabhan, Najla Alassim, Musharaf Sadat, Eman Al Qasim, Hani Tamim, Yaseen M Arabi
BACKGROUND: Clinical handover is an important process for the transition of patient-care responsibility to the next healthcare provider, but it may divert the attention of the team away from active patients. This is challenging in the Emergency Department (ED) because of highly dynamic patient conditions and is likely relevant in conditions that requires time-sensitive therapies, such as sepsis. We aimed to examine the management and outcomes of patients presenting with sepsis and septic shock to the ED during nursing handover...
January 18, 2018: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29347507/predictability-and-strength-of-a-heterogeneous-system-the-role-of-system-size-and-disorder
#17
Subhadeep Roy
In this paper, I have studied the effect of disorder (δ) and system size (L) in a fiber bundle model with a certain range R of stress redistribution. The strength of the bundle as well as the failure abruptness is observed with varying disorder, stress release range, and system sizes. With a local stress concentration, the strength of the bundle is observed to decrease with system size. The behavior of such decrements changes drastically as disorder strength is tuned. At moderate disorder, σ_{c} scales with the system size as σ_{c}∼1/logL...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347479/strength-distribution-of-large-unidirectional-composite-patches-with-realistic-load-sharing
#18
Ankit Gupta, Sivasambu Mahesh, Shyam M Keralavarma
Monte Carlo simulations of the failure of unidirectional fiber composites in a plane transverse to the fiber direction are performed on much larger patches than in previous works, assuming a realistic load redistribution scheme from broken to intact fibers. Computational effort involved in these simulations is substantially reduced using an algorithm based on the quadtree data structure. The empirical strength distribution obtained from the simulations has a weak-link character, regardless of the variability in fiber strengths...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347278/modes-of-failure-in-disordered-solids
#19
Subhadeep Roy, Soumyajyoti Biswas, Purusattam Ray
The two principal ingredients determining the failure modes of disordered solids are the strength of heterogeneity and the length scale of the region affected in the solid following a local failure. While the latter facilitates damage nucleation, the former leads to diffused damage-the two extreme natures of the failure modes. In this study, using the random fiber bundle model as a prototype for disordered solids, we classify all failure modes that are the results of interplay between these two effects. We obtain scaling criteria for the different modes and propose a general phase diagram that provides a framework for understanding previous theoretical and experimental attempts of interpolation between these modes...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346921/orthotropic-hydraulic-permeability-of-arrays-of-parallel-cylinders
#20
Mohsen Maleki, Robert J Martinuzzi, Walter Herzog, Salvatore Federico
Approximate analytical methods are presented to calculate the overall orthotropic hydraulic permeability of a flow with low Reynolds number, passing through a bundle of parallel circular cylinders. Two particular distributions are considered: (i) arrays with ordered rectangular lattices and (ii) irregular nonrandom distributions for which the unit cell cross sections are elliptical. The standard unit cell models, originally developed by Happel and Kuwabara for a random distribution of cylinders, are adapted to the case of nonrandom distributions...
September 2017: Physical Review. E
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