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https://www.readbyqxmd.com/read/29223954/effect-of-pcsk9-inhibitors-on-clinical-outcomes-in-patients-with-hypercholesterolemia-a-meta-analysis-of-35-randomized-controlled-trials
#1
REVIEW
Aris Karatasakis, Barbara A Danek, Judit Karacsonyi, Bavana V Rangan, Michele K Roesle, Thomas Knickelbine, Michael D Miedema, Houman Khalili, Zahid Ahmad, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: We sought to examine the efficacy and safety of 2 PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors: alirocumab and evolocumab. METHODS AND RESULTS: We performed a systematic review and meta-analysis of randomized controlled trials comparing treatment with and without PCSK9 inhibitors; 35 randomized controlled trials comprising 45 539 patients (mean follow-up: 85.5 weeks) were included. Mean age was 61.0±2.8 years, and mean baseline low-density lipoprotein cholesterol was 106±22 mg/dL...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29207948/homozygous-grid2-missense-mutation-predicts-a-shift-in-the-d-serine-binding-domain-of-glud2-in-a-case-with-generalized-brain-atrophy-and-unusual-clinical-features
#2
Zafar Ali, Shumaila Zulfiqar, Joakim Klar, Johan Wikström, Farid Ullah, Ayaz Khan, Uzma Abdullah, Shahid Baig, Niklas Dahl
BACKGROUND: Spinocerebellar ataxias comprise a large and heterogeneous group of disorders that may present with isolated ataxia, or ataxia in combination with other neurologic or non-neurologic symptoms. Monoallelic or biallelic GRID2 mutations were recently reported in rare cases with cerebellar syndrome and variable degree of ataxia, ocular symptoms, hypotonia and developmental delay. CASE PRESENTATION: We report on a consanguineous family with autosomal recessive childhood onset of slowly progressive cerebellar ataxia and delayed psychomotor development in three siblings...
December 6, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29204365/the-age-rage-axis-in-an-arab-population-the-united-arab-emirates-healthy-futures-uaehfs-pilot-study
#3
Claire K Inman, Abdullah Aljunaibi, Hyunwook Koh, Abdishakur Abdulle, Raghib Ali, Abdullah Alnaeemi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al-Maskari, Ayesha Al Dhaheri, Syed M Shah, Laila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Hosani, Muna Haji, Divya Galani, Matthew J O'Connor, Jiyoung Ahn, Tomas Kirchhoff, Scott Sherman, Richard B Hayes, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt
Aims: The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods: 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries...
December 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29192811/effects-of-vitamin-d-on-ovary-in-dhea-treated-pcos-rat-model-a-light-and-electron-microscopic-study
#4
Latife Seyran Çelik, Yurdun Kuyucu, Ebru Dündar Yenilmez, Abdullah Tuli, Kenan Dağlıoğlu, Ufuk Özgü Mete
AIM: The aim of this study was to investigate the effects of vitamin D treatment on ovary in experimentally designed polycystic ovary syndrome of female rats using light and electron microscopic techniques. METHODS: Twenty-four female pre-pubertal rats were divided into control, DHEA and DHEA+Vit.D groups. In DHEA group, the PCOS rat model was developed by 6mg/kg/day dehydroepiandrosterone administration as subcutaneously injections. In DHEA+Vit.D group, 6 mg/kg/day DHEA and 120ng/100g/week 1,25(OH)2D3 was performed simultaneously...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29187162/isolation-and-characterization-of-a-new-naturally-immortalized-human-breast-carcinoma-cell-line-kaimrc1
#5
Rizwan Ali, Nosaibah Samman, Hajar Al Zahrani, Atef Nehdi, Sabhi Rahman, Abdul Latif Khan, Mohamed Al Balwi, Lolwah Abdullah Alriyees, Manal Alzaid, Ahmed Al Askar, Mohamed Boudjelal
BACKGROUND: Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cells are being derived from other ethnic groups. Here we describe for the first time the establishment of a naturally transformed breast cancer cell line, KAIMRC1 from an Arab woman of age 62 suffering from stage IIB breast cancer (T2N1M0). Moreover, we have characterized these cells for the biological and molecular markers, induction of MAPK pathways as well as its response to different commercially available drugs and compounds...
November 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29186984/healthy-immigrant-families-randomized-controlled-trial-of-a-family-based-nutrition-and-physical-activity-intervention
#6
Mark L Wieland, Marcelo M M Hanza, Jennifer A Weis, Sonja J Meiers, Christi A Patten, Matthew M Clark, Jeff A Sloan, Paul J Novotny, Jane W Njeru, Adeline Abbenyi, James A Levine, Miriam Goodson, Graciela D Porraz Capetillo, Ahmed Osman, Abdullah Hared, Julie A Nigon, Irene G Sia
PURPOSE: To evaluate a healthy eating and physical activity intervention for immigrant families, derived through community-based participatory research. DESIGN: The Healthy Immigrant Families study was a randomized controlled trial with delayed intervention control group, with families as the randomization unit. SETTING: US Midwest city. PARTICIPANTS: Participants were recruited by community partners from Hispanic, Somali, and Sudanese immigrant communities...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29183008/correlates-of-pulmonary-function-in-children-with-sickle-cell-disease-and-elevated-fetal-hemoglobin
#7
Adekunle D Adekile, Asmaa Azab, Abdullah Owayed, Mousa Khadadah
OBJECTIVE: The current study was carried out to compare pulmonary function tests (PFT) in pediatric Kuwaiti sickle cell disease (SCD) patients to age-matched normal controls and to investigate the association of PFTS to selected clinical and laboratory parameters. SUBJECTS AND METHODS: There were 38 patients with SCD and 36 controls in the study. The patients were recruited from the Pediatric Hematology Clinics of Mubarak Al-Kabeer and Al-Amiri Hospitals, Kuwait and were studied in steady state...
November 28, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29178845/classification-of-a-new-phytoplasmas-subgroup-16srii-w-associated-with-crotalaria-witches-broom-diseases-in-oman-based-on-multigene-sequence-analysis
#8
Ali Al-Subhi, Saskia A Hogenhout, Rashid A Al-Yahyai, Abdullah M Al-Sadi
BACKGROUND: Crotalaria aegyptiaca, a low shrub is commonly observed in the sandy soils of wadis desert and is found throughout all regions in Oman. A survey for phytoplasma diseases was conducted. During a survey in a wild area in the northern regions of Oman in 2015, typical symptoms of phytoplasma infection were observed on C. aegyptiaca plants. The infected plants showed an excessive proliferation of their shoots and small leaves. RESULTS: The presence of phytoplasma in the phloem tissue of symptomatic C...
November 25, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29135370/pharmacokinetics-based-adjusted-versus-standard-dose-of-ribavirin-does-not-improve-virologic-response-rates-in-chronic-hepatitis-c-genotype-4-patients-a-randomized-controlled-trial
#9
Ibrahim H Altraif, Faisal Sanai, Mohammed A Babatin, Abduljaleel A Alalwan, Ayman A Abdo, Waleed Alhamoudi, Musthafa Peedikayil, Hamdan Alghamdi, Fahad Alsohaibani, Khalid A Alswat, Shazia Murtaza, Abdullah Alghamdi, Sara Altraif, Abdulrahman Aljumah, Fayaz A Handoo, Abdulkareem M AlBekairy, Hamad I Al-Ashgar, Mohammed Alquaiz, Mohammed A Alblawi, Waleed AlTamimi, Véronique Loustaud-Ratti, Pierre Marquett
Optimal doses of Ribavirin (RBV) for hepatitis C virus (HCV) treatment are not known. To assess the safety and efficacy of PegIFNalfa-2a in combination with an adjusted (ADJ) RBV dose based on early pharmacokinetics versus a fixed standard (STD) dose of RBV in chronic HCV genotype (GT) 4-naive patients in a randomized trial. One hundred eighty-one patients were randomized. The baseline variables were similar in both arms and females were 50.3% of the patients, 76.5% had minimal-moderate fibrosis (F0-2). Sustained virologic response (SVR) was achieved in 99 (54...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29133852/nitrosynapsin-therapy-for-a-mouse-mef2c-haploinsufficiency-model-of-human-autism
#10
Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D Zaremba, Timothy Holland, Neha Bansal, Daniel R Holohan, Kevin Lopez, Scott D Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H Geschwind, Amanda J Roberts, Alexey V Terskikh, Robert A Rissman, Eliezer Masliah, Stuart A Lipton, Nobuki Nakanishi
Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechanisms underlying MEF2C haploinsufficiency syndrome remain poorly understood. Here we report that Mef2c (+/-)(Mef2c-het) mice exhibit behavioral deficits resembling those of human patients. Gene expression analyses on brains from these mice show changes in genes associated with neurogenesis, synapse formation, and neuronal cell death...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29133034/cpap-treatment-for-children-with-pneumonia-in-low-resource-settings
#11
Eric D McCollum, Andrew G Smith, Michelle Eckerle, Tisungane Mvalo, Katherine L O'Brien, Abdullah H Baqui
No abstract text is available yet for this article.
November 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29126731/synthesis-antibacterial-properties-and-2d-qsar-studies-of-quinolone-triazole-conjugates
#12
Hassan M Faidallah, Adel S Girgis, Anand D Tiwari, Hitesh H Honkanadavar, Sean J Thomas, Ahmed Samir, Atef Kalmouch, Khalid A Alamry, Khalid A Khan, Tarek S Ibrahim, Amany M M Al-Mahmoudy, Abdullah M Asiri, Siva S Panda
A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10-15, 17-19 were synthesized via microwave assisted click chemistry technique. Some of the aryl-substituted conjugates 17-19 show promising antibacterial properties against the tested Gram-positive (S. aureus and S. pyogenes) and Gram-negative bacteria (S. typhi) with potency higher than that of the parent antibiotics 1-3. 2D-QSAR modeling supports the observed biological properties.
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29125452/prevalence-and-risk-factors-of-vitamin-d-insufficiency-and-deficiency-among-6-24-month-old-underweight-and-normal-weight-children-living-in-an-urban-slum-of-bangladesh
#13
Am Shamsir Ahmed, Tahmeed Ahmed, Kurt Z Long, Ricardo J Soares Magalhaes, Md Iqbal Hossain, Md Munirul Islam, Mustafa Mahfuz, Sm Abdul Gaffar, Atiya Sharmeen, Rashidul Haque, Richard L Guerrant, William A Petri, Abdullah Al Mamun
OBJECTIVE: We quantified the prevalence of vitamin D status in 6-24-month-old underweight and normal-weight children and identified the socio-economic and dietary predictors for status. DESIGN: Cross-sectional, baseline data from a nutritional intervention study were analysed. Multinomial logistic regression was used to estimate the odds of being vitamin D deficient or insufficient with the reference being vitamin D sufficient. SETTING: Urban slum area of Mirpur field site, Dhaka, Bangladesh...
July 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29125377/intraflagellar-transport-proteins-are-involved-in-thrombocyte-filopodia-formation-and-secretion
#14
Uvaraj Radhakrishnan, Abdullah Alsrhani, Hemalatha Sundaramoorthi, Gauri Khandekar, Meghana Kashyap, Jannon L Fuchs, Brian D Perkins, Yoshihiro Omori, Pudur Jagadeeswaran
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary cilia was unexpected. IFT proteins serve transport in cilia, whose narrow dimensions may have necessitated the evolution of IFT from vesicular transport in ancestral eukaryotes. We hypothesized that IFTs might also facilitate transport within the filopodia that form when thrombocytes are activated. To test this possibility, we knocked down ift122 expression by injecting antisense Morpholino oligonucleotides (MOs) into zebrafish embryos...
November 10, 2017: Platelets
https://www.readbyqxmd.com/read/29113607/directional-associations-between-memory-impairment-and-depressive-symptoms-data-from-a-longitudinal-sample-and-meta-analysis
#15
Junhong Yu, Hui-Ying Lim, Fadzillah Nur D/O Mohd Abdullah, Hui-Minn Chan, Rathi Mahendran, Roger Ho, Ee-Heok Kua, Michael John Power, Lei Feng
BACKGROUND: Previous cross-lagged studies on depression and memory impairment among the elderly have revealed conflicting findings relating to the direction of influence between depression and memory impairment. The current study aims to clarify this direction of influence by examining the cross-lagged relationships between memory impairment and depression in an Asian sample of elderly community dwellers, as well as synthesizing previous relevant cross-lagged findings via a meta-analysis...
November 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29106917/variation-in-prophylactic-antibiotic-use-for-laparoscopic-cholecystectomy-need-for-better-stewardship-in-pediatric-surgery
#16
Kibileri Williams, Lauren Baumann, Fizan Abdullah, Shawn D St Peter, Tolulope A Oyetunji
PURPOSE: The role of prophylactic antibiotics for elective laparoscopic cholecystectomy has been questioned over the last decade. Although gradually being discontinued in the adult population, the practice among pediatric surgeons remains unknown. Our aim was to investigate the use of perioperative antibiotics in children undergoing elective laparoscopic cholecystectomy (LC) for symptomatic cholelithiasis and biliary dyskinesia. METHODS: We retrospectively reviewed the Pediatric Health Information System (PHIS) database for 2015 and selected all patients 18years old or younger who underwent LC for cholelithiasis (without cholecystitis) or biliary dyskinesia...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29106662/preoperative-nomograms-predict-patient-specific-cervical-spine-surgery-clinical-and-quality-of-life-outcomes
#17
Daniel Lubelski, Vincent Alentado, Amy S Nowacki, Michael Shriver, Kalil G Abdullah, Michael P Steinmetz, Edward C Benzel, Thomas E Mroz
BACKGROUND: Clinical and quality of life (QOL) outcomes vary depending on the patient's demographics, comorbidities, presenting symptoms, pathology, and surgical treatment used. While there have been individual predictors identified, no comprehensive method incorporates a patient's complex clinical presentation to predict a specific individual postoperative outcome. OBJECTIVE: To create tool that predicts patient-specific outcomes among those undergoing cervical spine surgery...
June 29, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29102724/synthesis-of-benzo-d-imidazo-2-1-b-thiazole-chalcone-conjugates-as-microtubule-targeting-and-apoptosis-inducing-agents
#18
Faria Sultana, Srinivasa Reddy Bonam, V Ganga Reddy, V Lakshma Nayak, Ravikumar Akunuri, Sunitha Rani Routhu, Abdullah Alarifi, M Sampath Kumar Halmuthur, Ahmed Kamal
A series of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates (5a-aa) were designed, synthesized and evaluated for their cytotoxic potency against a panel of human cancer cell lines like lung (A-549), breast (MDA MB-231), prostrate (DU-145) and colon cancer (HT-29). Preliminary results revealed that some of these conjugates like 5d and 5u exhibited significant antiproliferative effect against human breast cancer (MDA MB-231) with IC50 values of 1.3 and 1.2 µM respectively. To investigate the mechanistic aspects underlying the activity, the detailed biological studies of these promising conjugates (5d and 5u) were carried out on the MDA MB-231 cancer cells...
November 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29100530/contributions-to-the-phylogeny-of-ixodes-pholeoixodes-canisuga-i-ph-kaiseri-i-ph-hexagonus-and-a-simple-pictorial-key-for-the-identification-of-their-females
#19
Sándor Hornok, Attila D Sándor, Relja Beck, Róbert Farkas, Lorenza Beati, Jenő Kontschán, Nóra Takács, Gábor Földvári, Cornelia Silaghi, Elisabeth Meyer-Kayser, Adnan Hodžić, Snežana Tomanović, Swaid Abdullah, Richard Wall, Agustín Estrada-Peña, Georg Gerhard Duscher, Olivier Plantard
BACKGROUND: In Europe, hard ticks of the subgenus Pholeoixodes (Ixodidae: Ixodes) are usually associated with burrow-dwelling mammals and terrestrial birds. Reports of Pholeoixodes spp. from carnivores are frequently contradictory, and their identification is not based on key diagnostic characters. Therefore, the aims of the present study were to identify ticks collected from dogs, foxes and badgers in several European countries, and to reassess their systematic status with molecular analyses using two mitochondrial markers...
November 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29098023/detection-of-somatic-mutations-in-the-mitochondrial-dna-control-region-d-loop-in-brain-tumors-the-first-report-in-malaysian-patients
#20
Abdul Aziz Mohamed Yusoff, Khairol Naaim Mohd Nasir, Khalilah Haris, Siti Zulaikha Nashwa Mohd Khair, Abdul Rahman Izaini Abdul Ghani, Zamzuri Idris, Jafri Malin Abdullah
Although the role of nuclear-encoded gene alterations has been well documented in brain tumor development, the involvement of the mitochondrial genome in brain tumorigenesis has not yet been fully elucidated and remains controversial. The present study aimed to identify mutations in the mitochondrial DNA (mtDNA) control region D-loop in patients with brain tumors in Malaysia. A mutation analysis was performed in which DNA was extracted from paired tumor tissue and blood samples obtained from 49 patients with brain tumors...
November 2017: Oncology Letters
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