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https://www.readbyqxmd.com/read/27912738/hepatoprotective-activity-of-lepidium-sativum-seeds-against-d-galactosamine-lipopolysaccharide-induced-hepatotoxicity-in-animal-model
#1
Mohammad Raish, Ajaz Ahmad, Khalid M Alkharfy, Syed Rizwan Ahamad, Kazi Mohsin, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea, Mushtaq Ahmad Ansari
BACKGROUND: Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis and high mortality there is urgent need for the development of safe and non-toxic hepatoprotective agents for the adequate management of hepatitis. Hepatoprotective effect of the Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/lipopolysaccharide (400 mg/kg and 30 μg/kg) liver damage model in rats. METHODS: Hepatoprotective activity of LSEE (150 and 300 mg/kg) and silymarin on D-GalN/LPS induced FHF in rat was assessed using several liver function enzyme parameters...
December 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27908689/pcsk9-genetic-variants-and-risk-of-type-2-diabetes-a-mendelian-randomisation-study
#2
Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O' Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-Pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk...
November 28, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27906795/factors-determining-the-outcome-of-hematopoietic-stem-cell-transplantation-in-patients-with-acute-lymphoblastic-leukemia-at-king-faisal-specialist-hospital-and-research-center-riyadh-saudi-arabia
#3
Suleimman Al-Sweedan, Amal Al-Seraihy, Ali Al-Ahmari, Abdullah Al-Jefri, Viqaruddin Mohammed, Rafat Jafri, Khawar Siddiqui, Mouhab Ayas
Medical records of 82 patients with acute lymphoblastic leukemia (ALL) who underwent hematopoietic cell transplantation (HCT) at our institution from 2005 to 2011 were reviewed. Forty-five patients were male (54.8%). The median age at HCT was 7.46 years (range, 0.98 to 14.31 y), the median time to HCT after diagnosis was 12.56 months. Ten patients were below the age of 1 year (12%). All patients were in complete remission at the time of HCT. In 83 transplants, 64 patients received HCT from human leukocyte antigen-identical-related donors and 19 from other donors...
November 30, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27903541/lifelong-physical-activity-regardless-of-dose-is-not-associated-with-myocardial-fibrosis
#4
Shuaib M Abdullah, Kyler W Barkley, Paul S Bhella, Jeffrey L Hastings, Susan Matulevicius, Naoki Fujimoto, Shigeki Shibata, Graeme Carrick-Ranson, M Dean Palmer, Nainesh Gandhi, Laura F DeFina, Benjamin D Levine
BACKGROUND: Recent reports have suggested that long-term, intensive physical training may be associated with adverse cardiovascular effects, including the development of myocardial fibrosis. However, the dose-response association of different levels of lifelong physical activity on myocardial fibrosis has not been evaluated. METHODS AND RESULTS: Seniors free of major chronic illnesses were recruited from predefined populations based on the consistent documentation of stable physical activity over >25 years and were classified into 4 groups by the number of sessions/week of aerobic activities ≥30 minutes: sedentary (group 1), <2 sessions; casual (group 2), 2 to 3 sessions; committed (group 3), 4 to 5 sessions; and Masters athletes (group 4), 6 to 7 sessions plus regular competitions...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27893073/association-between-severity-of-obstructive-sleep-apnea-and-number-and-sites-of-upper-airway-operations-with-surgery-complications
#5
Zamzil Amin Asha'ari, Jamalludin Ab Rahman, Abdul Hadi Mohamed, Kahairi Abdullah, Wan Ishlah Leman
Importance: In patients with obstructive sleep apnea (OSA), operative risks depend on the severity of the underlying OSA and the invasiveness of the surgical procedure. Objective: To investigate the nature of the associations between the severity of OSA and the number and anatomical sites of upper airway operations with operative complications. Design, Setting, and Participants: This retrospective study included adult patients diagnosed with OSA (apnea-hypopnea index [AHI], >5) who underwent upper airway surgery at a single tertiary referral hospital between October 1, 2008, and October 1, 2015...
November 23, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27862881/proximal-balloon-occlusion-versus-distal-filter-protection-in-carotid-artery-stenting-a-meta-analysis-and-review-of-the-literature
#6
Jad Omran, Ehtisham Mahmud, Christopher J White, Herbert D Aronow, Douglas E Drachman, William Gray, Obai Abdullah, Mazen Abu-Fadel, Belal Firwana, Gergory Mishkel, Ashraf S Al-Dadah
INTRODUCTION: Carotid artery stenting (CAS) is typically performed using embolic protection devices (EPDs) as a means to reduce the risk of procedure-related stroke. In this study, we compared procedural morbidity and mortality associated with distal (D-EPD) vs. proximal (P-EPD) protection. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were queried from January 1998 through May 2015. Only studies comparing (D-EPD) and (P-EPD) were included...
November 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27853181/selective-sweep-on-human-amylase-genes-postdates-the-split-with-neanderthals
#7
Charlotte E Inchley, Cynthia D A Larbey, Nzar A A Shwan, Luca Pagani, Lauri Saag, Tiago Antão, Guy Jacobs, Georgi Hudjashov, Ene Metspalu, Mario Mitt, Christina A Eichstaedt, Boris Malyarchuk, Miroslava Derenko, Joseph Wee, Syafiq Abdullah, François-Xavier Ricaut, Maru Mormina, Reedik Mägi, Richard Villems, Mait Metspalu, Martin K Jones, John A L Armour, Toomas Kivisild
Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced by selection. Here we assess amylase copy numbers in a global sample of 480 high coverage genomes and find that regions flanking the amylase locus show notable depression of genetic diversity both in African and non-African populations. Analysis of genetic variation in these regions supports the model of an early selective sweep in the human lineage after the split of humans from Neanderthals which led to the fixation of multiple copies of AMY1 in place of a single copy...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27845562/microbial-evaluation-of-the-effectiveness-of-different-methods-for-cleansing-clear-orthodontic-retainers-a-randomized-clinical-trial
#8
Rehaf H Albanna, Hisham M Farawanah, Abdullah M Aldrees
OBJECTIVE: To compare effectiveness of brushing an Essix retainer with water only and brushing followed by soaking in one of three commercial cleansing tablets. MATERIALS AND METHODS: A double-blind, parallel, randomized clinical trial with a split-mouth design was completed with 60 volunteers with specific eligibility criteria assigned to three groups to compare the cleansing effectiveness of brushing an Essix retainer with water only, followed by soaking in one of three alkaline peroxide-based commercial cleansing tablets (Retainer Brite(®), Kukis(®), and Corega(®))...
November 15, 2016: Angle Orthodontist
https://www.readbyqxmd.com/read/27843130/reduction-of-childhood-pneumonia-mortality-in-the-sustainable-development-era
#9
Eric D McCollum, Carina King, Laura L Hammitt, Amy S Ginsburg, Tim Colbourn, Abdullah H Baqui, Katherine L O'Brien
No abstract text is available yet for this article.
November 11, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27816299/early-recurrence-patterns-following-totally-intracorporeal-robot-assisted-radical-cystectomy-results-from-the-eau-robotic-urology-section-erus-scientific-working-group
#10
Justin W Collins, Abolfazl Hosseini, Christofer Adding, Tommy Nyberg, Anthony Koupparis, Edward Rowe, Matthew Perry, Rami Issa, Martin C Schumacher, Carl Wijburg, Abdullah E Canda, Melvin D Balbay, Karel Decaestecker, Christian Schwentner, Arnulf Stenzl, Sebastian Edeling, Saša Pokupić, Fredrik D'Hondt, Alexander Mottrie, Peter N Wiklund
: Recurrence following radical cystectomy often occurs early, with >80% of recurrences occurring within the first 2 yr. Debate remains as to whether robot-assisted radical cystectomy (RARC) negatively impacts early recurrence patterns because of inadequate resection or pneumoperitoneum. We report early recurrence patterns among 717 patients who underwent RARC with intracorporeal urinary diversion at nine different institutions with a minimum follow-up of 12 mo. Clinical, pathologic, radiologic, and survival data at the latest follow-up were collected...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27815641/the-impact-of-surgical-strategies-on-outcomes-for-pediatric-chronic-pancreatitis
#11
Maria G Sacco Casamassima, Seth D Goldstein, Jingyan Yang, Colin D Gause, Fizan Abdullah, Avner Meoded, Martin A Makary, Paul M Colombani
PURPOSE: To review our institutional experience in the surgical treatment of pediatric chronic pancreatitis (CP) and evaluate predictors of long-term pain relief. METHODS: Outcomes of patients ≤21 years surgically treated for CP in a single institution from 1995 to 2014 were evaluated. RESULTS: Twenty patients underwent surgery for CP at a median of 16.6 years (IQR 10.7-20.6 years). The most common etiology was pancreas divisum (n = 7; 35%)...
November 4, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27802184/the-role-of-tks-adaptor-proteins-in-invadopodia-formation-growth-and-metastasis-of-melanoma
#12
Shinji Iizuka, Christopher Abdullah, Matthew D Buschman, Begoña Diaz, Sara A Courtneidge
Metastatic cancer cells are characterized by their ability to degrade and invade through extracellular matrix. We previously showed that the Tks adaptor proteins, Tks4 and Tks5, are required for invadopodia formation and/or function in Src-transformed fibroblasts and a number of human cancer cell types. In this study, we investigated the role of Tks adaptor proteins in melanoma cell invasion and metastasis. Knockdown of either Tks4 or Tks5 in both mouse and human melanoma cell lines resulted in a decreased ability to form invadopodia and degrade extracellular matrix...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27784271/diastolic-versus-systolic-ankle-brachial-pressure-index-using-ultrasound-imaging-automated-oscillometric-measurement-in-diabetic-patients-with-calcified-and-non-calcified-lower-limb-arteries
#13
Akram M Asbeutah, Abdullah A AlMajran, Sami K Asfar
BACKGROUND: Ankle-brachial pressure index-systolic (ABI-s) can be falsely elevated in the presence of calcified lower limb arteries in some diabetic patients and therefore loses its value in this cohort of patients. We aim at investigating the feasibility of using the diastolic (ABI-d) instead of ABI-s to calculate the ABI in diabetic patients with calcified limb arteries. METHODS: A total of 51 patients were chosen from the diabetic foot clinic. Twenty six of these patients had calcified leg arteries by Duplex scan (Group A) and 25 patients did not have calcifications in their leg arteries (Group B)...
October 26, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27774150/a-single-source-precursor-approach-to-solution-processed-indium-arsenide-thin-films
#14
Peter Marchand, Sanjayan Sathasivam, Benjamin A D Williamson, David Pugh, Salem M Bawaked, Sulaiman N Basahel, Abdullah Y Obaid, David O Scanlon, Ivan P Parkin, Claire J Carmalt
This paper reports the synthesis of the novel single-source precursor, [{(MeInAs (t) Bu)3}2(Me2InAs( (t) Bu)H)2] and the subsequent first report of aerosol-assisted chemical vapour deposition of InAs thin films. Owing to the use of the single-source precursor, highly crystalline and stoichiometric films were grown at a relatively low deposition temperature of 450 °C. Core level XPS depth profiling studies showed some partial oxidation of the film surface, however this was self-limiting and disappeared on etch profiles...
July 28, 2016: Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices
https://www.readbyqxmd.com/read/27770255/characterisation-of-vitamin-d-related-molecules-and-calcium-sensing-receptor-in-human-fallopian-tube-during-the-menstrual-cycle-and-in-ectopic-pregnancy
#15
Bassem Refaat, Jawwad Ahmad, Shakir Idris, Fadi Fayez Kamfar, Ahmed Mohamed Ashshi, Sarah Abdullah Batwa, Faizah Ahmed Malibary
This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca(2+) sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). Fresh FTs were obtained during total abdominal hysterectomy at the follicular (n = 16) and midluteal (n = 16) phases. Specimens from remote and implantation sites as well as trophoblastic tissues were also freshly collected from each FT with EP (n = 10)...
October 22, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27767230/a-school-based-program-for-tobacco-and-alcohol-prevention-in-special-education-effectiveness-of-the-modified-healthy-school-and-drugs-intervention-and-moderation-by-school-subtype
#16
Abdullah Turhan, Simone Onrust, Peter Ten Klooster, Marcel Pieterse
AIMS: To test effectiveness of the Healthy School and Drugs (HSD) program on tobacco and alcohol use in Dutch secondary special education (SE) schools, and whether this depends on subtypes of SE-schools and the level of implementation. DESIGN: In a quasi-experimental design with baseline and post-treatment follow-up 35 classes (N = 363) were allocated arbitrarily or depending on teacher motivation to either intervention condition (N = 205) or usual curriculum (N = 158)...
October 21, 2016: Addiction
https://www.readbyqxmd.com/read/27747271/spatial-variation-of-arsenic-in-soil-irrigation-water-and-plant-parts-a-microlevel-study
#17
M S Kabir, M A Salam, D N R Paul, M I Hossain, N M F Rahman, Abdullah Aziz, M A Latif
Arsenic pollution became a great problem in the recent past in different countries including Bangladesh. The microlevel studies were conducted to see the spatial variation of arsenic in soils and plant parts contaminated through ground water irrigation. The study was performed in shallow tube well command areas in Sadar Upazila (subdistrict), Faridpur, Bangladesh, where both soil and irrigation water arsenic are high. Semivariogram models were computed to determine the spatial dependency of soil, water, grain, straw, and husk arsenic (As)...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27746584/the-effect-of-poly-adp-ribose-polymerase-1-gene-3-untranslated-region-polymorphism-in-colorectal-cancer-risk-among-saudi-cohort
#18
Abdullah M Alhadheq, Jilani Purusottapatnam Shaik, Abdullah Alamri, Abdulrahman M Aljebreen, Othman Alharbi, Majid A Almadi, Faten Alhadeq, Nahla A Azzam, Abdelhabib Semlali, Mohammad Alanazi, Mohammad D Bazzi, Narasimha Reddy Parine
Background. DNA repair systems are essential for each cell to repair and maintain the genome integrity. Base excision repair pathway is one of the crucial pathways to maintain genome integrity and PARP-1 plays a key role in BER pathway. The purpose of this study is to evaluate the association between polymorphisms in PARP-1 3'untranslated region (3'UTR) SNP rs8679 and its expression in colorectal cancer. Methods. Genotyping and gene expression were performed using TaqMan assays. The effects of age, gender, and tumor location were evaluated in cases and controls regarding the genotyping results...
2016: Disease Markers
https://www.readbyqxmd.com/read/27746226/efficacy-of-a-russian-backbone-live-attenuated-influenza-vaccine-among-young-children-in-bangladesh-a-randomised-double-blind-placebo-controlled-trial
#19
W Abdullah Brooks, K Zaman, Kristen D C Lewis, Justin R Ortiz, Doli Goswami, Jodi Feser, Amina Tahia Sharmeen, Kamrun Nahar, Mustafizur Rahman, Mohammed Ziaur Rahman, Burc Barin, Muhammad Yunus, Alicia M Fry, Joseph Bresee, Tasnim Azim, Kathleen M Neuzil
BACKGROUND: The rates of influenza illness and associated complications are high among children in Bangladesh. We assessed the clinical efficacy and safety of a Russian-backbone live attenuated influenza vaccine (LAIV) at two field sites in Bangladesh. METHODS: Between Feb 27 and April 9, 2013, children aged 2-4 years in urban Kamalapur and rural Matlab, Bangladesh, were randomly assigned in a 2:1 ratio, according to a computer-generated schedule, to receive one intranasal dose of LAIV or placebo...
December 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27737646/maternal-vitamin-d-supplementation-during-pregnancy-and-lactation-to-prevent-acute-respiratory-infections-in-infancy-in-dhaka-bangladesh-mdari-trial-protocol-for-a-prospective-cohort-study-nested-within-a-randomized-controlled-trial
#20
Shaun K Morris, Lisa G Pell, Mohammed Ziaur Rahman, Michelle C Dimitris, Abdullah Mahmud, M Munirul Islam, Tahmeed Ahmed, Eleanor Pullenayegum, Tahmid Kashem, Shaila S Shanta, Jonathan Gubbay, Eszter Papp, Michelle Science, Stanley Zlotkin, Daniel E Roth
BACKGROUND: Early infancy is a high-risk period for severe acute respiratory infection (ARI), particularly in low-income countries with resource-limited health systems. Lower respiratory tract infection (LRTI) is commonly preceded by upper respiratory infection (URTI), and often caused by respiratory syncytial virus (RSV), influenza and other common community-acquired viral pathogens. Vitamin D status is a candidate modifiable early-life determinant of the host antiviral immune response and thus may influence the risk of ARI-associated morbidity in high-risk populations...
October 13, 2016: BMC Pregnancy and Childbirth
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