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https://www.readbyqxmd.com/read/29332189/the-arabidopsis-histone-chaperone-fact-is-required-for-stress-induced-expression-of-anthocyanin-biosynthetic-genes
#1
Alexander Pfab, Matthias Breindl, Klaus D Grasser
The histone chaperone FACT is involved in the expression of genes encoding anthocyanin biosynthetic enzymes also upon induction by moderate high-light and therefore contributes to the stress-induced plant pigmentation. The histone chaperone FACT consists of the SSRP1 and SPT16 proteins and associates with transcribing RNAPII (RNAPII) along the transcribed region of genes. FACT can promote transcriptional elongation by destabilising nucleosomes in the path of RNA polymerase II, thereby facilitating efficient transcription of chromatin templates...
January 13, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29332050/supplemental-retinal-carotenoids-enhance-memory-in-healthy-individuals-with-low-levels-of-macular-pigment-in-a-randomized-double-blind-placebo-controlled-clinical-trial
#2
Rebecca Power, Robert F Coen, Stephen Beatty, Riona Mulcahy, Rachel Moran, Jim Stack, Alan N Howard, John M Nolan
BACKGROUND: There is a biologically plausible rationale whereby the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), which are collectively referred to as macular pigment (MP) in the central retina (macula), support the maintenance of cognition via their antioxidant and anti-inflammatory properties. OBJECTIVE: To investigate the impact of supplemental L, Z, and MZ on memory, executive function, and verbal fluency among healthy individuals with low MP levels...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331864/taxonomic-studies-on-aegyria-apoliva-sp-nov-and-trithigmostoma-cucullulus-m%C3%A3-ller-1786-jankowski-1967-ciliophora-cyrtophoria-with-phylogenetic-analyses
#3
Xumiao Chen, Lifang Li, Saleh A Al-Farraj, Honggang Ma, Hongbo Pan
The morphology, including the ciliary pattern, of two cyrtophorid ciliates, namely Aegyria apoliva sp. nov. and Trithigmostoma cucullulus (Müller, 1786) Jankowski, 1967, were investigated. They were isolated from coastal water off Qingdao and from an estuarine habitat in south China, respectively. Aegyria apoliva sp. nov. is characterized as following: body size 100-120 × 50-70 μm in vivo with dark pigment spot on anterior left part of cell; 48-69 somatic kineties; one preoral and four or five circumoral kineties; 9-13 transpodial segments; 26-40 nematodesmal rods; 6-10 contractile vacuoles...
December 28, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/29331830/fetal-development-of-the-poeppig-s-woolly-monkey-lagothrix-poeppigii
#4
Rafael Dos Santos de Andrade, Frederico Ozanan Barros Monteiro, Hani Rocha El Bizri, Wilter Ricardo Russiano Vicente, Diva Anelie de Araujo Guimarães, Pedro Mayor
The intrauterine development is an evolutionary strategy that prepares the neonate for extra-uterine life, thus providing important information on the life history of species. In this study, we described the external and internal morphology of 25 fetuses of Poeppig's woolly monkeys (Lagothrix poeppigii) by taking advantage of a 10-year participatory collection of biological samples originated from animals hunted for subsistence purposes in the Peruvian Amazon. Logistic regressions estimated the probability of occurrence of each external morphological characteristic in relation to the crown-rump length (CRL)...
December 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29331788/curcumin-inhibits-cardiac-hypertrophy-and-improves-cardiovascular-function-via-enhanced-na-ca2-exchanger-expression-after-transverse-abdominal-aortic-constriction-in-rats
#5
Xiao-Jie Bai, Jun-Tao Hao, Jin Wang, Wei-Fang Zhang, Cai-Ping Yan, Jia-Hui Zhao, Zhi-Qing Zhao
BACKGROUND: This study tested the hypothesis that inhibition of cardiac hypertrophy and preservation of cardiac/endothelial function by the natural yellow pigment curcumin are associated with upregulated expression of Na+/Ca2+ exchanger (NCX) after transverse aortic constriction (TAC). METHODS: Male Wistar rats were subjected to TAC for 10 weeks and curcumin (50 mg/kg/day) was fed by gastric gavage during TAC. Expression of NCX and endothelial nitric oxide synthase (eNOS) was analyzed by Western blot and immunohistochemistry...
July 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29330174/views-and-experiences-of-seeking-information-and-help-for-vitiligo-a-qualitative-study-of-written-accounts
#6
Emma Teasdale, Ingrid Muller, Amirah Abdullah Sani, Kim S Thomas, Beth Stuart, Miriam Santer
OBJECTIVES: Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information and help for vitiligo. DESIGN: Qualitative analysis of free-text responses to four open-ended questions in an online survey...
January 11, 2018: BMJ Open
https://www.readbyqxmd.com/read/29329973/altered-gene-expression-in-tree-shrew-retina-and-retinal-pigment-epithelium-produced-by-short-periods-of-minus-lens-wear
#7
Li He, Michael R Frost, John T Siegwart, Thomas T Norton
Hyperopic refractive error is detected by retinal neurons, which generate GO signals through a direct emmetropization signaling cascade: retinal pigment epithelium (RPE) into choroid and then into sclera, thereby increasing axial elongation. To examine signaling early in this cascade, we measured gene expression in the retina and RPE after short exposure to hyperopia produced by minus-lens wear. Gene expression in each tissue was compared with gene expression in combined retina + RPE. Starting 24 days after normal eye opening, three groups of juvenile tree shrews (n = 7 each) wore a monocular -5 D lens...
January 9, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29329868/a-procedure-for-the-measurement-of-oxygen-consumption-rates-ocrs-in-red-wines-and-some-observations-about-the-influence-of-wine-initial-chemical-composition
#8
Almudena Marrufo-Curtido, Vanesa Carrascón, Mónica Bueno, Vicente Ferreira, Ana Escudero
The rates at which wine consumes oxygen are important technological parameters for whose measurement there are not accepted procedures. In this work, volumes of 8 wines are contacted with controlled volumes of air in air-tight tubes containing oxygen-sensors and are further agitated at 25 °C until O2 consumption is complete. Three exposure levels of O2 were used: low (10 mg/L) and medium or high (18 or 32 mg/L plus the required amount to oxidize all wine SO2). In each oxygen level, 2-4 independent segments following pseudo-first order kinetics were identified, plus an initial segment at which wine consumed O2 very fast...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329812/synergistic-effect-of-polysaccharides-betalain-pigment-and-phenolic-compounds-of-red-prickly-pear-opuntia-stricta-in-the-stabilization-of-salami
#9
Nadia Kharrat, Hedia Salem, Aicha Mrabet, Fatma Aloui, Soumaya Triki, Ahmed Fendri, Youssef Gargouri
The aim of this work is to try to substitute some synthetic additives by a natural extract from red prickly pear (Opuntia stricta) which known by its richness on bioactive polysaccharides mainly consisting of galactose, rhamnose and galacturonic acid. This natural fruit has a high content of carbohydrates above 18.81% FM. It contains also a high level of polyphenols 152.25 ± 0.26 μg QE/mg PPE and flavonoids about 370.60 ± 0.12 μg GAE/mg of PPE. In addition, prickly pear extract (PPE) displayed a strong antioxidant and antimicrobial activities...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329580/evidence-for-the-activation-of-pyroptotic-and-apoptotic-pathways-in-rpe-cells-associated-with-nlrp3-inflammasome-in-the-rodent-eye
#10
Jiangyuan Gao, Jing Z Cui, Eleanor To, Sijia Cao, Joanne A Matsubara
BACKGROUND: Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mechanisms for RPE degeneration in AMD are still unresolved. The prevailing theories consider that each cell death pathway works independently and without regulation of each other. Building upon our previous work in which we induced a short burst of inflammasome activity in vivo, we now investigate the effects of prolonged inflammasome activity on RPE cell death mechanisms in rats...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29329540/children-with-albinism-in-african-regions-their-rights-to-being-and-doing
#11
Anita Franklin, Patricia Lund, Caroline Bradbury-Jones, Julie Taylor
BACKGROUND: Albinism is an inherited condition with a relatively high prevalence in populations throughout sub-Saharan Africa. People with oculocutaneous albinism have little or no pigment in their hair, skin and eyes; thus they are visually impaired and extremely sensitive to the damaging effect of the sun on their skin. Aside from the health implications of oculocutaneous albinism, there are also significant sociocultural risks. The impacts of albinism are particularly serious in areas that associate albinism with legend and folklore, leading to stigmatisation and discrimination...
January 12, 2018: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/29329469/pigment-dispersion-syndrome-mimicking-congenital-horner-syndrome
#12
Bao Khanh Tran, Aki Kawasaki
No abstract text is available yet for this article.
January 12, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29329235/a-review-of-the-biological-activities-of-microalgal-carotenoids-and-their-potential-use-in-healthcare-and-cosmetic-industries
#13
REVIEW
Ramaraj Sathasivam, Jang-Seu Ki
Carotenoids are natural pigments that play pivotal roles in many physiological functions. The characteristics of carotenoids, their effects on health, and the cosmetic benefits of their usage have been under investigation for a long time; however, most reviews on this subject focus on carotenoids obtained from several microalgae, vegetables, fruits, and higher plants. Recently, microalgae have received much attention due to their abilities in producing novel bioactive metabolites, including a wide range of different carotenoids that can provide for health and cosmetic benefits...
January 12, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29329098/effect-of-organic-amendments-on-cadmium-stress-to-pea-a-multivariate-comparison-of-germinating-vs-young-seedlings-and-younger-vs-older-leaves
#14
Saliha Shamshad, Muhammad Shahid, Marina Rafiq, Sana Khalid, Camille Dumat, Muhammad Sabir, Behzad Murtaza, Abu Bakr Umer Farooq, Noor S Shah
Despite significant recent advancement in research, biogeochemical behavior of heavy metals with respect to their applied form is still topical. Moreover, metal toxicity to plants may vary with their stage of development/maturity. Therefore, this study for the first time evaluated the influence of ethylenediaminetetraacetic acid (EDTA) and citric acid (CA) on cadmium (Cd) accumulation and toxicity to germinating and young pea seedlings as well as in younger and older leaves. The experimental setup of current study consisted of two separate studies...
January 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29328999/discovery-of-novel-piperonyl-derivatives-as-diapophytoene-desaturase-inhibitors-for-the-treatment-of-methicillin-vancomycin-and-linezolid-resistant-staphylococcus-aureus-infections
#15
Hanwen Wei, Fei Mao, Shuaishuai Ni, Feifei Chen, Baoli Li, Xiaoxia Qiu, Linghao Hu, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan, Jian Li
Inhibition of S. aureus diapophytoene desaturase (CrtN) could serve as an alternative approach for addressing the tricky antibiotic resistance by blocking the biosynthesis of carotenoid pigment which shields the bacterium from host oxidant killing. In this study, we designed and synthesized 44 derivatives with piperonyl scaffold targeting CrtN and the structure-activity relationships (SARs) were examined extensively to bring out the discovery of 21b with potent efficacy and better hERG safety profile compared to the first class CrtN inhibitor benzocycloalkane derivative 2...
December 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29328919/color-processing-in-the-early-visual-system-of-drosophila
#16
Christopher Schnaitmann, Väinö Haikala, Eva Abraham, Vitus Oberhauser, Thomas Thestrup, Oliver Griesbeck, Dierk F Reiff
Color vision extracts spectral information by comparing signals from photoreceptors with different visual pigments. Such comparisons are encoded by color-opponent neurons that are excited at one wavelength and inhibited at another. Here, we examine the circuit implementation of color-opponent processing in the Drosophila visual system by combining two-photon calcium imaging with genetic dissection of visual circuits. We report that color-opponent processing of UVshort/blue and UVlong/green is already implemented in R7/R8 inner photoreceptor terminals of "pale" and "yellow" ommatidia, respectively...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29327060/optical-coherence-tomography-analysis-of-the-optic-nerve-head-and-surrounding-structures-in-long-duration-international-space-station-astronauts
#17
Nimesh Patel, Anastas Pass, Sara Mason, Charles R Gibson, Christian Otto
Importance: After long-duration spaceflight, morphological changes in the optic nerve head (ONH) and surrounding tissues have been reported. Objective: To develop methods to quantify ONH and surrounding tissue changes using preflight and postflight optical coherence tomographic scans of the ONH region. Design, Setting, and Participants: Two separate analyses were done on retrospective data, with the first comparing a preflight group with a control group, followed by preflight to postflight analysis...
January 11, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29327028/transition-metals-and-trace-elements-in-the-retinal-pigment-epithelium-and-choroid-correlative-ultrastructural-and-chemical-analysis-by-analytical-electron-microscopy-and-nano-secondary-ion-mass-spectrometry
#18
Antje Biesemeier, Oliver Eibl, Santhana Eswara, Jean-Nicolas Audinot, Tom Wirtz, Ulrich Schraermeyer
Understanding the localisation and abundance of structural elements, trace elements and especially transition metals like Cu and Zn in ocular tissue sections is important for physiology, and also for the characterisation of diseases related to oxidative stress like age-related macular degeneration. Transition metal abundances were investigated in an aged donor eye by nano-secondary ion mass spectrometry (nano-SIMS) elemental mapping using Cs+ and O- primary ions, respectively, and correlated to their respective mole fractions investigated by analytical electron microscopy (AEM)...
January 12, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29325768/retraction-notice-to-pigment-epithelium-derived-factor-play-a-positive-role-in-bone-mineralization-of-osteoblasts-derived-from-diabetic-patients-gene-627c-2017-563-568-of-retracted-article
#19
Na Song, Jiateng Zhong, Jinghang Zhang, Jian Yu, Jinsong Li, Jinbo Qi, Jun Yang, Yanyan Qiu, Wei Su, Zhiwei Feng, Haijun Wang
No abstract text is available yet for this article.
March 1, 2018: Gene
https://www.readbyqxmd.com/read/29325220/profile-risk-factors-and-outcome-of-acute-kidney-injury-in-pediatric-acute-on-chronic-liver-failure
#20
Bikrant Bihari Lal, Seema Alam, Vikrant Sood, Dinesh Rawat, Rajeev Khanna
There are no studies on acute kidney injury (AKI) in pediatric acute-on-chronic liver failure (ACLF). This study was planned with aim to describe the clinical presentation and outcome of AKI among pediatric ACLF patients METHODS: Data of all children 1-18 years of age presenting with ACLF (APASL definition) was reviewed. AKI was defined as per KDIGO guidelines. Poor outcome was defined as death or need for liver transplant within 3 months of development of AKI RESULTS: A total of 84 children with ACLF presented to us in the study period...
January 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
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