keyword
MENU ▼
Read by QxMD icon Read
search

C reactive protein

keyword
https://www.readbyqxmd.com/read/28343311/mechanistic-insight-of-platelet-apoptosis-leading-to-non-surgical-bleeding-among-heart-failure-patients-supported-by-continuous-flow-left-ventricular-assist-devices
#1
Nandan K Mondal, Tielou Li, Zengsheng Chen, Hegang H Chen, Erik N Sorensen, Si M Pham, Michael A Sobieski, Steven C Koenig, Mark S Slaughter, Bartley P Griffith, Zhongjun J Wu
Non-surgical bleeding (NSB) is the most common clinical complication in heart failure (HF) patients supported by continuous-flow left ventricular assist devices (CF-LVADs). In this study, oxidative stress and alteration of signal pathways leading to platelet apoptosis were investigated. Thirty-one HF patients supported by CF-LVADs were divided into bleeder (n = 12) and non-bleeder (n = 19) groups. Multiple blood samples were collected at pre-implant (baseline) and weekly up to 1-month post-implant. A single blood sample was collected from healthy subjects (reference)...
March 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28343262/cavin-1-deficiency-modifies-myocardial-and-coronary-function-stretch-responses-and-ischaemic-tolerance-roles-of-nos-over-activity
#2
Mika Kaakinen, Melissa E Reichelt, Zhibin Ma, Charles Ferguson, Nick Martel, Enzo R Porrello, James E Hudson, Walter G Thomas, Robert G Parton, John P Headrick
Caveolae and associated cavin and caveolins may govern myocardial function, together with responses to mechanical and ischaemic stresses. Abnormalities in these proteins are also implicated in different cardiovascular disorders. However, specific roles of the cavin-1 protein in cardiac and coronary responses to mechanical/metabolic perturbation remain unclear. We characterised cardiovascular impacts of cavin-1 deficiency, comparing myocardial and coronary phenotypes and responses to stretch and ischaemia-reperfusion in hearts from cavin-1 (+/+) and cavin-1 (-/-) mice...
May 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28343225/clinical-trial-of-vadadustat-in-patients-with-anemia-secondary-to-stage-3-or-4-chronic-kidney-disease
#3
Edouard R Martin, Mark T Smith, Bradley J Maroni, Qing C Zuraw, Emil M deGoma
BACKGROUND: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being investigated for the treatment of anemia secondary to CKD. METHODS: A phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging trial (NCT01381094) was undertaken in adults with anemia secondary to CKD stage 3 or 4...
March 25, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28342988/an-anti-inflammatory-dietary-intervention-to-reduce-breast-cancer-recurrence-risk-study-design-and-baseline-data
#4
Amelie G Ramirez, Dorothy Long Parma, Edgar Muñoz, Kristin D Mendoza, Crystel Harb, Alan E C Holden, Michael Wargovich
U.S. breast cancer survivors (BCSs) are expected to increase to 4 million in the next 5-10years. Cancer recurrence risk is highest among obese survivors. Inflammatory (Pro-I) biomarkers including C-reactive protein (CRP), Interleukins -3, -6, and -8 (IL-3, IL-6, IL-8), and Tumor Necrosis Factor (TNF)-α have been associated with cancer recurrence risk. Nutritional interventions aimed at reducing inflammation (INF) may contribute to reduced cancer recurrence risk, but studies have been limited to animal models...
March 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28342967/the-effects-of-omega-3-fatty-acids-and-vitamin-e-co-supplementation-on-clinical-and-metabolic-status-in-patients-with-parkinson-s-disease-a-randomized-double-blind-placebo-controlled-trial
#5
Mohsen Taghizadeh, Omid Reza Tamtaji, Ehsan Dadgostar, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Javad Abolhassani, Mohammad Hossein Aarabi, Ebrahim Kouchaki, Mohammad Reza Memarzadeh, Zatollah Asemi
The current research was performed to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on clinical signs and metabolic status in people with Parkinson's disease (PD). This randomized double-blind placebo-controlled clinical trial was conducted in 60 patients with PD. Participants were randomly assigned into two groups to receive either 1000 mg omega-3 fatty acids from flaxseed oil plus 400 IU vitamin E supplements (n = 30) or placebo (n = 30) for 12 weeks. Unified Parkinson's disease rating stage (UPDRS) were recorded at baseline and the after 3-month intervention...
March 22, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28342782/the-modified-glasgow-prognostic-score-in-patients-undergoing-surgery-for-bone-and-soft-tissue-sarcoma
#6
Rossel Morhij, Ashish Mahendra, Mike Jane, Donald C McMillan
BACKGROUND: The prognostic significance of markers of the systemic inflammatory response in patients with soft tissue and bone sarcomas remains unclear. Therefore, the present study aimed to compare the prognostic value of markers of the systemic inflammatory response in patients undergoing surgery for primary soft tissue and bone sarcoma. METHOD: Patients who underwent resection of primary soft tissue/bone sarcoma between 2008 and 2012 and had pre-operative measurements of the systemic inflammatory response [C-reactive protein, albumin, white cell, neutrophil, lymphocyte and platelet counts, and the combination of C-reactive protein and albumin (mGPS)] were included in the study (n = 111)...
February 24, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28340377/possible-protective-effect-of-royal-jelly-against-cyclophosphamide-induced-prostatic-damage-in-male-albino-rats-a-biochemical-histological-and-immuno-histo-chemical-study
#7
Sara Mohammed Naguib Abdel-Hafez, Rehab Ahmed Rifaai, Walaa Yehia Abdelzaher
Almost all the chemotherapy treat many cancer types effectively, but it leads to severe side effects. Chemotherapy like cyclophosphamide (CP) not works only on the active cells, such as cancer cells, but also acts on the healthy cells. Royal jelly (RJ) was reported to have a lot of therapeutic effects besides being an anti-oxidant and anti-cancer agent. The purpose of this study was to assess the possible protective role of RJ in ameliorating the toxic effects of CP overdose in the rat prostatic tissue. The rats were separated into 4 groups; control group, RJ group, CP group and RJ with CP group...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28339557/deficiency-of-circulating-progenitor-cells-associated-with-vascular-thrombosis-of-hemodialysis-patients
#8
Mu-Yang Hsieh, Tsung-Yan Chen, Lin Lin, Shao-Yuan Chuang, Shing-Jong Lin, Der-Cheng Tarng, Po-Hsun Huang, Chih-Cheng Wu
Background.: Hemodialysis (HD) patients have an increased risk of thrombosis. Endothelial progenitor cells (EPCs), which function in vascular repair, are deficient in HD patients. Nonetheless, the relationship between EPC deficiency and thrombosis in HD patients is unknown. Methods.: From January 2010 to December 2012, circulating levels of EPCs that were positive for CD34 and kinase insert domain receptor (KDR) were measured in 269 HD patients. Patients received prospective follow-ups at 6-month intervals until May 2015...
January 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339417/cynicism-as-subscale-of-burnout
#9
Margaretha Viljoen, Nicolaas Claassen
BACKGROUND: Cynicism, as a personality trait, has adverse effects on health. The question was asked whether cynical attitudes that develop due to work-related stress correlate with stress levels and whether it has a negative influence on health. OBJECTIVES: To investigate associations of the cynicism subscale scores of the Maslach Burnout Inventory-General Survey (MBI-GS) with levels of stress, anxiety, questionnaire-based physical health and with a number of physiological health risk indicators...
March 23, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28339365/thresholds-for-the-28-joint-disease-activity-score-das28-using-c-reactive-protein-are-lower-compared-to-das28-using-erythrocyte-sedimentation-rate-in-early-rheumatoid-arthritis
#10
Bindee Kuriya, Orit Schieir, Daming Lin, Juan Xiong, Janet Pope, Gilles Boire, Boulos Haraoui, John Carter Thorne, Diane Tin, Carol Hitchon, Shahin Jamal, Edward Keystone, Vivien P Bykerk
OBJECTIVES: The 28-Joint Disease Activity Score (DAS28) using C-reactive protein (CRP) and DAS28 using erythrocyte sedimentation rate (DAS28-ESR) may not be interchangeable. We sought to compare and estimate optimal thresholds for the DA28-CRP for use in early rheumatoid arthritis (ERA). METHODS: Patients from the Canadian Early Arthritis Cohort with baseline and 12 months' data for both DAS28-ESR and DAS28-CRP were examined for correlations and differences between DAS28-CRP and DAS28-ESR across their range of values...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339354/the-effects-of-an-educational-meeting-and-subsequent-computer-reminders-on-the-ordering-of-laboratory-tests-by-rheumatologists-an-interrupted-time-series-analysis
#11
Nienke Lesuis, Nathan den Broeder, Nadine Boers, Ester Piek, Steven Teerenstra, Marlies Hulscher, Ronald van Vollenhoven, Alfons A den Broeder
OBJECTIVES: To examine the effects of an educational meeting and subsequent computer reminders on the number of ordered laboratory tests. METHODS: Using interrupted time series analysis we assessed whether trends in the number of laboratory tests ordered by rheumatologists between September 2012 and September 2015 at the Sint Maartenskliniek (the Netherlands) changed following an educational meeting (September 2013) and the introduction of computer reminders into the Computerised Physician Order Entry System (July 2014)...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339044/suppression-of-nuclear-factor-erythroid%C3%A2-2%C3%A2-related-factor-2%C3%A2-mediated-antioxidative-defense-in-the-lung-injury-induced-by-chronic-exposure-to-methamphetamine-in-rats
#12
Yang Bai, Yun Wang, Ming Liu, Yu-Han Gu, Bin Jiang, Xu Wu, Huai-Liang Wang
The imbalance between oxidative stress and antioxidant defense is important in the pathogenesis of lung diseases. Nuclear factor erythroid‑2‑related factor 2 (Nrf2) is a key transcriptional factor that regulates the antioxidant response. The purpose of the present study was to investigate whether Nrf2‑mediated antioxidative defense is involved in methamphetamine (MA)‑induced lung injury in rats. Following establishment of chronic MA toxicity in rats, Doppler ultrasonic detection was used to measure the changes of physiological indexes, followed by hematoxylin and eosin staining, ELISA and western blot analysis...
March 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338890/metabolic-syndrome-and-insulin-resistance-are-associated-with-frailty-in-older-adults-a-prospective-cohort-study
#13
Raúl F Pérez-Tasigchana, Luz M León-Muñoz, Esther Lopez-Garcia, Juan L Gutierrez-Fisac, Martín Laclaustra, Fernando Rodríguez-Artalejo, Pilar Guallar-Castillón
Background: diabetes increases the risk of frailty that is a leading cause of disability and premature mortality in older people. Metabolic syndrome (MS) and insulin resistance (IR) are strong risk factors for diabetes and could, thus, lead to frailty. However, the association between MS or IR and frailty has barely been investigated. Methods: data were obtained from a cohort of 1,499 community-dwelling individuals aged ≥60, who were free of diabetes at 2008-10 and were followed up for 3...
March 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28338837/associations-of-leukocyte-telomere-length-with-aerobic-and-muscular-fitness-in-young-adults
#14
Dylan M Williams, Jessica L Buxton, Marko T Kantomaa, Tuija H Tammelin, Alexandra I F Blakemore, Marjo-Riitta Järvelin
Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952-5,205, varying by exposure-outcome analysis)...
March 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28338321/thiol-reactive-star-polymers-display-enhanced-association-with-distinct-human-blood-components
#15
Joshua Julian Glass, Yang Li, Robert De Rose, Angus P R Johnston, Ewa I Czuba, Song Yang Khor, John F Quinn, Michael R Whittaker, Thomas P Davis, Stephen J Kent
Directing nanoparticles to specific cell types using non-antibody based methods is of increasing interest. Thiol-reactive nanoparticles can enhance the efficiency of cargo delivery into specific cells through interactions with cell surface proteins. However, studies to date using this technique have been largely limited to immortalized cell lines or rodents and the utility of this technology on primary human cells is unknown. Herein, we used RAFT polymerization to prepare pyridyl disulphide (PDS)-functionalized star polymers with a methoxy-poly(ethylene glycol) brush corona and a fluorescently-labelled crosslinked core using an arm-first method...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28338222/long-term-self-reported-cognitive-problems-after-delirium-in-the-intensive-care-unit-and-the-effect-of-systemic-inflammation
#16
Annemiek E Wolters, Linda M Peelen, Dieuwke S Veldhuijzen, Irene J Zaal, Dylan W de Lange, Wietze Pasma, Diederik van Dijk, Olaf L Cremer, Arjen J C Slooter
OBJECTIVES: To describe the association between intensive care unit (ICU) delirium and self-reported cognitive problems in 1-year ICU survivors, and investigate whether this association was altered by exposure to systemic inflammation during ICU stay. DESIGN: Prospective cohort study. SETTING: Dutch medical-surgical ICU. PARTICIPANTS: One-year ICU survivors, admitted to the ICU ≥48 hours. MEASUREMENTS: Self-reported cognitive problems were measured with the Cognitive Failures Questionnaire (CFQ)...
March 24, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28338196/study-on-the-proliferation-of-human-gastric-cancer-cell-ags-by-activation-of-egfr-in-h2o2
#17
Q Wang, W Shen, G-Q Tao, J Sun, L-P Shi
OBJECTIVE: This study is to investigate the effect of low concentration hydrogen peroxide (H2O2) on the proliferation of gastric cancer AGS cell line in vitro and the mechanism. MATERIALS AND METHODS: AGS cells were treated with different low concentrations of H2O2 (1, 0.1, 0.01, and 0.001 μm) for 48 hours. The effect of H2O2 concentration gradient on the activity of AGS cell activities was detected by methyl thiazolyl tetrazolium (MTT) method. The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28338001/renin-angiotensin-system-acting-on-reactive-oxygen-species-in-paraventricular-nucleus-induces-sympathetic-activation-via-at1r-pkc%C3%AE-rac1-pathway-in-salt-induced-hypertension
#18
Qing Su, Chan-Juan Huo, Hong-Bao Li, Kai-Li Liu, Xiang Li, Qing Yang, Xin-Ai Song, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang
Brain renin-angiotensin system (RAS) could regulate oxidative stress in the paraventricular nucleus (PVN) in the development of hypertension. This study was designed to explore the precise mechanisms of RAS acting on reactive oxygen species (ROS) in salt-induced hypertension. Male Wistar rats were administered with a high-salt diet (HS, 8.0% NaCl) for 8 weeks to induced hypertension. Those rats were received PVN infusion of AT1R antagonist losartan (LOS, 10 μg/h) or microinjection of small interfering RNAs for protein kinase C γ (PKCγ siRNA) once a day for 2 weeks...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337889/detection-of-combined-procalcitonin-and-c-reactive-protein-applied-in-the-diagnosis-of-bacterial-infections
#19
Y L Li, L C Zhai, J H Ji, L Y Liu
In recent years, procalcitonin and C-reactive protein have been used as important indexes in the detection of inflammation. In order to analyze the combined detection of procalcitonin and C-reactive protein in infected patients, 57 subjects in the Clinical Laboratory of Zhengzhou Maternal and Child Health Hospital with a bacterial infection were selected as the observation group. Correspondingly, 57 non-infected subjects were selected for the control group. The procalcitonin and C-reactive protein levels in the included cases were analyzed and compared by extracting peripheral blood...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337426/pathogen-identification-in-suspected-cases-of-pyogenic-spondylodiscitis
#20
Ahmad Farajzadeh Sheikh, Azar D Khosravi, Hamed Goodarzi, Roohangiz Nashibi, Alireaza Teimouri, Azim Motamedfar, Reza Ranjbar, Sara Afzalzadeh, Mehrandokht Cyrus, Mohammad Hashemzadeh
Pyogenic spinal infection continues to represent a worldwide problem. In approximately one-third of patients with pyogenic spondylodiscitis, the infectious agent is never identified. Of the cases that lead to organismal identification, bacteria are more commonly isolated from the spine rather than fungi and parasites. This study applied universal prokaryotic 16S rRNA PCR as a rapid diagnostic tool for the detection of bacterial agents in specimens from patients suspected of pyogenic spondylodiscitis. Gram and Ziehl-Neelsen staining were used as a preliminary screening measure for microbiologic evaluation of patient samples...
2017: Frontiers in Cellular and Infection Microbiology
keyword
keyword
10812
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"