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https://www.readbyqxmd.com/read/29775012/-the-clinical-value-of-china-savin-pollen-extract-used-for-skin-prick-test
#1
Kai Guan, J X Zhou, R Q Wang, J Yin, L L Wang, Y X Zhi, J L Sun, H Li, L P Wen, J Q Gu, R Tang, Z X Wang, L S Li, T Xu
Objective: The aim of this study is to evaluate the effectiveness and safety of China Savin pollen extract which was used for skin prick test (SPT) in the diagnosis of China Savin pollen allergy. Method: Patients with diagnosis of allergic diseases were collected from Allergy Department of Peking Union Medical College Hospital. All patients were given SPT with China Savin pollen extract, and the mean wheal diameter (MWD) was measured after 15 minutes. Receiver operating characteristic curve (ROC) analysis was performed based on the results of serum specific immunoglobulin E (sIgE)...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774921/a-flexible-pressure-sensor-based-on-rgo-polyaniline-wrapped-sponge-with-tunable-sensitivity-for-human-motion-detection
#2
Gang Ge, Yichen Cai, Qiuchun Dong, Yizhou Zhang, Jinjun Shao, Wei Huang, Xiaochen Dong
High-performance stretchable and wearable electronic skins (E-skins) with high sensitivity and a large sensing range are urgently required with the rapid development of the Internet of things and artificial intelligence. Herein, a reduced graphene oxide (rGO)/polyaniline wrapped sponge is prepared via rGO coating and the in situ synthesis of polyaniline nanowires (PANI NWs) on the backbones of sponge for the fabrication of pressure sensors. From the as-prepared flexible sensor, tunable sensitivity (0.042 to 0...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29774148/genetic-variations-in-the-tlr3-locus-are-associated-with-eosinophilic-esophagitis
#3
Robledo Ávila-Castellano, José-Raúl García-Lozano, Stefan Cimbollek, Alfredo J Lucendo, Juan-Manuel Bozada, Joaquín Quiralte
Background: Eosinophilic esophagitis (EoE) is an antigen-driven disease mediated by an abnormal immune Th2 response. Objective: The objective of this article is to investigate genes associated with regulating immune responses leading to disease susceptibility. Methods: Twenty-seven tag single nucleotide polymorphisms (tSNPs) selected in five candidate genes ( TLR3, TLR4, FOXP3, FLG and TSLP ) were genotyped in 218 EoE patients and 376 controls...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29772057/a-4d-global-respiratory-motion-model-of-the-thorax-based-on-ct-images-a-proof-of-concept
#4
H Fayad, M Gilles, T Pan, D Visvikis
PURPOSE: Respiratory motion reduces the sensitivity and specificity of medical images especially in the thoracic and abdominal areas. It may affect applications such as cancer diagnostic imaging and/or radiation therapy (RT). Solutions to this issue include modelling of the respiratory motion in order to optimize both diagnostic and therapeutic protocols. Personalised motion modeling required patient specific four dimensional (4D) imaging which in the case of 4D computed tomography (4D CT) acquisition is associated with an increased dose...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29769578/metabolomic-profile-of-systemic-sclerosis-patients
#5
Federica Murgia, Silvia Svegliati, Simone Poddighe, Milena Lussu, Aldo Manzin, Tatiana Spadoni, Colomba Fischetti, Armando Gabrielli, Luigi Atzori
Systemic sclerosis (SSc) is an autoimmune disease of unknown aetiology characterized by vascular lesions, immunological alterations and diffuse fibrosis of the skin and internal organs. Since recent evidence suggests that there is a link between metabolomics and immune mediated disease, serum metabolic profile of SSc patients and healthy controls was investigated by 1 H-NMR and GC-MS techniques. The results indicated a lower level of aspartate, alanine, choline, glutamate, and glutarate in SSc patients compared with healthy controls...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29767974/in-vitro-and-in-vivo-demonstration-of-human-ovarian-cancer-necrosis-through-a-water-soluble-and-near-infrared-absorbing-chlorin
#6
Betsy Marydasan, Bollapalli Madhuri, Shirisha Cherukommu, Jedy Jose, Mambattakkara Viji, Suneesh C Karunakaran, Tavarekere K Chandrashekar, Kunchala Sridhar Rao, Ch Mohan Rao, Danaboyina Ramaiah
With an objective to develop efficient sensitizers for therapeutical applications, we synthesized a water soluble, 5,10,15,20-tetrakis(3,4-dihydroxyphenyl)chlorin (TDC), and investigated its in vitro and in vivo biological efficacy and compared with the commercially available sensitizers. TDC showed high water solubility (6-fold), when compared to Foscan and exhibited excellent triplet excited state () and singlet oxygen () yields. In vitro photobiological investigations in human ovarian cancer cell lines SKOV-3 showed high photocytotoxicity, negligible dark toxicity, rapid cellular uptake and specific localization of TDC in neoplastic cells as assessed by flow cytometric cell-cycle and propidium iodide staining analysis...
May 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29767652/peripheral-glial-cell-line-derived-neurotrophic-factor-facilitates-the-functional-recovery-of-mechanical-nociception-following-inferior-alveolar-nerve-transection-in-rats
#7
Masahiro Watanabe, Masamichi Shinoda, Dulguun Batbold, Naoyuki Sugano, Shuichi Sato, Koichi Iwata
AIMS: To identify endogenous sources of glial cell line-derived neurotrophic factor (GDNF) at the injury site following inferior alveolar nerve transection (IANX) and to determine whether GDNF signaling promotes the recovery of orofacial pain sensation. METHODS: Nociceptive mechanical sensitivity of the facial skin was assessed following IANX (n = 10) or sham operation (n = 7). GDNF-positive cells were identified and the amount of GDNF measured in the injured region of IANX rats (n = 10) and in sham rats (n = 10)...
May 15, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29767649/experimental-psychological-stress-on-quantitative-sensory-testing-response-in-patients-with-temporomandibular-disorders
#8
Dyna Mara Araújo Oliveira Ferreira, Yuri Martins Costa, Henrique Müller de Quevedo, Leonardo Rigoldi Bonjardim, Paulo César Rodrigues Conti
AIMS: To assess the modulatory effects of experimental psychological stress on the somatosensory evaluation of myofascial temporomandibular disorder (TMD) patients. METHODS: A total of 20 women with myofascial TMD and 20 age-matched healthy women were assessed by means of a standardized battery of quantitative sensory testing. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), mechanical pain threshold (MPT), wind-up ratio (WUR), and pressure pain threshold (PPT) were performed on the facial skin overlying the masseter muscle...
May 15, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29766368/systemic-contact-dermatitis
#9
REVIEW
Marcella Aquino, Greg Rosner
Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29766227/noncontrast-computed-tomography-factors-predictive-of-extracorporeal-shock-wave-lithotripsy-outcomes-in-patients-with-pancreatic-duct-stones
#10
Ri Liu, Weiwei Su, Jing Gong, Yu Zhang, Jianping Lu
PURPOSE: To assess the usefulness of factors unique to NCCT for the prediction of ESWL outcomes in patients with pancreatic duct stones. MATERIALS AND METHODS: We retrospectively evaluated 148 patients with multiple PDS who had undergone ESWL therapy. All patients received an examination for NCCT both before and after ESWL. The following parameters were measured and recorded: patient characteristics including sex and age; NCCT parameters including mean stone length, mean stone volumes before and after ESWL, mean value of CT attenuation, standard deviation of CT attenuation, variation coefficient of CT attenuation, skin-to-stone distance, and pancreatic duct diameter; ESWL outcome indexes including stone clearance rate calculated using the formula [Formula: see text], and the number of ESWL sessions...
May 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29766046/deletion-of-tsc2-in-nociceptors-reduces-target-innervation-ion-channel-expression-and-sensitivity-to-heat
#11
Dan Carlin, Judith P Golden, Amit Mogha, Vijay K Samineni, Kelly R Monk, Robert W Gereau, Valeria Cavalli
The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems. However, excess mTORC1 activation may promote innervation defects, and mTORC1 activity mediates injury-induced hypersensitivity, reducing enthusiasm for the pathway as a therapeutic target. While mTORC1 activity is required for full expression of some pain modalities, the effects of pathway activation on nociceptor phenotypes and sensory behaviors are currently unknown...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29765431/skin-perfusion-pressure-for-the-prediction-of-wound-healing-in-critical-limb-ischemia-a-meta-analysis
#12
REVIEW
Xuanliang Pan, Chuangang You, Guoxian Chen, Huawei Shao, Chunmao Han, Lizhu Zhi
Introduction: The purpose of this meta-analysis was to determine the value and efficacy of skin perfusion pressure (SPP) for the prediction of wound healing in patients with critical limb ischemia. Material and methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched from inception until December 31, 2014 using combinations of the following keywords: skin perfusion pressure, limb ischemia, wound healing, prediction. Randomized controlled trials, 2-arm prospective studies, and retrospective studies that measured SPP in patients with limb ischemia were included...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29762893/retrobulbar-vs-peribulbar-regional-anesthesia-techniques-using-bupivacaine-in-dogs
#13
Yael Shilo-Benjamini, Peter J Pascoe, David J Maggs, Steven R Hollingsworth, Ann R Strom, Kathryn L Good, Sara M Thomasy, Philip H Kass, Erik R Wisner
OBJECTIVE: To compare the effectiveness of retrobulbar anesthesia (RBA) and peribulbar anesthesia (PBA) in dogs. ANIMAL STUDIED: Six adult mixed-breed dogs (18-24 kg). PROCEDURES: In a randomized, masked, crossover trial with a 10-day washout period, each dog was sedated with intravenously administered dexmedetomidine and administered 0.5% bupivacaine:iopamidol (4:1) as RBA (2 mL via a ventrolateral site) or PBA (5 mL divided equally between ventrolateral and dorsomedial sites)...
May 15, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29762654/testing-of-disposable-protective-garments-against-isocyanate-permeation-from-spray-polyurethane-foam-insulation
#14
Michael P Mellette, Dhimiter Bello, Yalong Xue, Michael Yost, Anila Bello, Susan Woskie
Background: Diisocyanates (isocyanates), including methylene diphenyl diisocyanate (MDI), are the primary reactive components of spray polyurethane foam (SPF) insulation. They are potent immune sensitizers and a leading cause of occupational asthma. Skin exposure to isocyanates may lead to both irritant and allergic contact dermatitis and possibly contribute to systemic sensitization. More than sufficient evidence exists to justify the use of protective garments to minimize skin contact with aerosolized and raw isocyanate containing materials during SPF applications...
May 12, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29761729/safety-assessment-of-magnesium-sulfate-as-used-in-cosmetics
#15
Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of magnesium sulfate, which functions as a bulking agent in cosmetic products and is reportedly used at concentrations up to 11% and 25% in leave-on and rinse-off products, respectively. The Panel noted that the history of safe medical use of magnesium sulfate provides further confidence that there are no significant toxicity concerns relating to systemic exposure to this ingredient after cosmetic product application. Furthermore, the extensive clinical experience of the Panel, including the results of numerous patch tests, indicates that magnesium salts do not have the potential to induce sensitization...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29761728/safety-assessment-of-hydrolyzed-wheat-protein-and-hydrolyzed-wheat-gluten-as-used-in-cosmetics
#16
Christina Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel determined that data from clinical and laboratory studies were sufficient to demonstrate that these ingredients will not elicit type 1 immediate hypersensitivity reactions in sensitized individuals and will not induce sensitization when the polypeptide lengths of the hydrolysates do not exceed 30 amino acids...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29761483/epithelial-barrier-dysfunctions-in-atopic-dermatitis-a-skin-gut-lung-model-linking-microbiome-alteration-and-immune-dysregulation
#17
REVIEW
T H Zhu, T R Zhu, K A Tran, R K Sivamani, V Y Shi
Atopic dermatitis is a systemic disorder characterized by abnormal barrier function across multiple organ sites. Initial disruption in the skin epidermal barrier permits allergen sensitization and colonization by pathogens. This induces TH 2 inflammatory response and a thymic stromal lymphopoietin mediated pathway that further promotes barrier breakdown at distant sites including the intestinal and respiratory tract. Clinically, atopic dermatitis can progress from skin disease to food allergy, allergic rhinitis, and later asthma, a phenomenon commonly known as the atopic march...
May 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29761315/hair-detection-and-lesion-segmentation-in-dermoscopic-images-using-domain-knowledge
#18
Sameena Pathan, K Gopalakrishna Prabhu, P C Siddalingaswamy
Automated segmentation and dermoscopic hair detection are one of the significant challenges in computer-aided diagnosis (CAD) of melanocytic lesions. Additionally, due to the presence of artifacts and variation in skin texture and smooth lesion boundaries, the accuracy of such methods gets hampered. The objective of this research is to develop an automated hair detection and lesion segmentation algorithm using lesion-specific properties to improve the accuracy. The aforementioned objective is achieved in two ways...
May 15, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29760999/potential-of-short-wave-infrared-spectroscopy-for-quantitative-depth-profiling-of-stratum-corneum-lipids-and-water-in-dermatology
#19
Anna Ezerskaia, Natallia Eduarda Uzunbajakava, Gerwin J Puppels, Johanna de Sterke, Peter J Caspers, H Paul Urbach, Babu Varghese
We demonstrate the feasibility of short wave infrared (SWIR) spectroscopy combined with tape stripping for depth profiling of lipids and water in the stratum corneum of human skin. The proposed spectroscopic technique relies on differential detection at three wavelengths of 1720, 1750, and 1770 nm, with varying ratio of the lipid-to-water absorption coefficient and an 'isosbestic point'. Comparison of the data acquired using SWIR spectroscopy with that obtained by a gold standard for non-invasive quantitative molecular-specific skin measurements, namely confocal Raman spectroscopy (CRS), revealed specificity of the proposed modality for water and lipid quantification...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760612/trends-in-folic-acid-supplementation-during-pregnancy-the-effect-on-allergy-development-in-children
#20
Anna Socha-Banasiak, Barbara Kamer, Krzysztof Pacześ, Barbara Ślusarek, Bartosz Pawlikowski, Elżbieta Czkwianianc
Introduction: The results of some previous studies suggested that maternal folate supplementation during pregnancy may contribute to allergy development in offspring. Aim: This study was performed to examine the influence of maternal folic acid intake prior to and during pregnancy on the development of various types of allergy in children taking into account the timing and dosage of supplemented folate. Material and methods: The retrospective study was performed between 2010 and 2014 in 307 child-mother pairs (203 allergic children and 104 children without allergy symptoms, aged 2-72 months)...
April 2018: Postȩpy Dermatologii i Alergologii
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