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Sensitive Skin

Yang Song, Feilu Wang, Zhenya Zhang
Decoupling research on flexible tactile sensors play a very important role in the intelligent robot skin and tactile-sensing fields. In this paper, an efficient machine learning method based on the improved back-propagation (BP) algorithm is proposed to decouple the mapping relationship between the resistances of force-sensitive conductive pillars and three-dimensional forces for the 6 × 6 novel flexible tactile sensor array. Tactile-sensing principles and numerical experiments are analyzed. The tactile sensor array model accomplishes the decomposition of the force components by its delicate structure, and avoids direct interference among the electrodes of the sensor array...
May 14, 2018: Micromachines
Weiting Liu, Xiaoying Cheng, Xiaodong Ruan, Xin Fu
This present paper describes a novel method to fabricate tactile sensor arrays by producing aligned multi-walled carbon nanotubes (MWNTs)-polyurethane (PU) composite sub-microfiber (SMF) arrays with the electrospinning technique. The proposed sensor was designed to be used as the artificial skin for a tactile sensation system. Although thin fibers in micro- and nanoscale have many good mechanical characteristics and could enhance the alignment of MWNTs inside, the high impedance as a consequence of a small section handicaps its application...
April 24, 2018: Micromachines
Ji-Liang Zhang, Chun-Nuan Zhang, Er-Chao Li, Miao-Miao Jin, Mao-Xian Huang, Wei Cui, Yang-Yang Lin, Ya-Jun Shi
The impacts of triphenyltin (TPT) on ecological health have been of great concern due to their widespread use and ubiquity in aquatic ecosystems. However, little is known about the effects of TPT on the reproductive behaviors of fishes. Therefore, the present study was conducted to investigate the effects of TPT at environmentally relevant concentrations (0, 1 and 10 ng Sn/L) on the mating behaviors and the attractiveness to females during mating in male guppies (Poecilia reticulata). The results showed that TPT exposure disturbed the mating behaviors; the TPT-exposed male fish performed more sneaking attempts, but no changes in sigmoid courtship were displayed...
November 10, 2018: Ecotoxicology and Environmental Safety
Dean E Schraufnagel, John Balmes, Clayton T Cowl, Sara De Matteis, Soon-Hee Jung, Kevin Mortimer, Rogelio Perez-Padilla, Mary B Rice, Horacio Riojas-Rodroguez, Akshay Sood, George D Thurston, Teresa To, Anessa Vanker, Donald J Wuebbles
Although air pollution is well-known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million chronic obstructive pulmonary disease (COPD) deaths can be attributed to air pollution, but air pollution may also account for 19% of all cardiovascular deaths and 21% of all stroke deaths. Air pollution has been linked to other malignancies, such as bladder cancer and childhood leukemia. Lung development in childhood is stymied with exposure to air pollutants, and poor lung development in children predicts lung impairment in adults...
November 9, 2018: Chest
Jeremiah Hwee, Lillian Sung, Jeffrey C Kwong, Rinku Sutradhar, Karen Tu, Jason D Pole
While medical records have detailed information, they are limited in reach to the availability and accessibility of those records. On the other hand, administrative data while limited in scope, have a much further reach in coverage of an entire population. However, few studies have validated the use of administrative data for identifying infections in pediatric populations. Pediatric patients from Ontario, Canada aged <18 years were randomly sampled from the Electronic Medical Record Administrative data Linked Database (EMRALD)...
2018: PloS One
Hongming Lyu, Parag Gad, Hui Zhong, V Reggie Edgerton, Aydin Babakhani
This work presents a miniaturized W-level implantable pulse generator (IPG) inductively powered at 430 MHz. Notches are intentionally applied to the incident power, which are replicated to precisely control the timing of the output pulses. Fabricated in 180 nm CMOS process, the concise circuitry occupies a pad-included footprint of 850 m 450 m and achieves a quiescent current consumption of 950 nA. To reduce the form factor, 401-457 MHz MedRadio-band is utilized to realize the induction link. The finalized assembly achieves one of the smallest dimensions (4...
November 9, 2018: IEEE Transactions on Biomedical Circuits and Systems
Hsiu-Lan Li, Shih-Wei Lin, Yi-Ting Hwang
This study investigated the association between patient characteristics and the occurrence of pressure injuries for patients at the end of life. A retrospective study was conducted using data collected from 2062 patients at the end of life between January 2007 and October 2015. In addition to demographic data and pressure injury risk assessment scale scores, injury history, disease type, and length of hospitalization were revealed as the major independent variables for predicting the occurrence of pressure injuries...
November 9, 2018: Computers, Informatics, Nursing: CIN
Anastassios Doudoulakakis, Iris Spiliopoulou, Garyfallia Syridou, Nikolaos Giormezis, Maria Militsopoulou, Evangelia Lebessi, Maria Tsolia
A sharp increase in staphylococcal scalded skin syndrome (SSSS) cases has been recorded in our settings since 2015, with 31 cases having been documented during the period 2014-2017. The molecular investigation of strains from the above period showed the emergence of a methicillin-susceptible, mupirocin- and fusidic acid-resistant Staphyloccocus aureus clone that belongs to the ST121 complex and carries both epidermolysin (eta/etb) genes. We concluded that the SSSS caused by the newly emerged, highly virulent community-associated-methicillin sensitive S...
November 12, 2018: Journal of Medical Microbiology
Kahyun Sun, Hangil Ko, Hyun-Ha Park, Minho Seong, Sang-Hyeon Lee, Hoon Yi, Hyung Wook Park, Tae-Il Kim, Changhyun Pang, Hoon Eui Jeong
Low-dimensional nanomaterials are widely adopted as active sensing elements for electronic skins. When the nanomaterials are integrated with microscale architectures, the performance of the electronic skin is significantly altered. Here, it is shown that a high-performance flexible and stretchable electronic skin can be produced by incorporating a piezoresistive carbon nanotube composite into a hierarchical topography of micropillar-wrinkle hybrid architectures that mimic wrinkles and folds in human skin. Owing to the unique hierarchical topography of the hybrid architectures, the hybrid electronic skin exhibits versatile and superior sensing performance, which includes multiaxial force detection (normal, bending, and tensile stresses), remarkable sensitivity (20...
November 11, 2018: Small
Claudia Ansorge, Johannes M Miocic, Dagmar von Bubnoff, Kristin Technau-Hafsi
BACKGROUND AND OBJECTIVES: Recently, there have been increasing numbers of patients consulting emergency units in all medical disciplines. Our aim was to analyze the demographics, referral mode, symptoms, localization of lesions, prior treatment, diagnoses and hospitalization rate of dermatological patients. PATIENT AND METHODS: The study was conducted as a prospective single center survey over six months in the dermatology unit of a university hospital in Germany...
November 12, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
T Nh Leung, K L Hon, A Kc Leung
Group A β-haemolytic Streptococcus or Streptococcus pyogenes is a gram-positive coccus that tends to grow in chains. Streptococcus pyogenes is the cause of many important human diseases, ranging from pharyngitis and mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Mild Streptococcus pyogenes infections include pharyngitis (strep throat) and localised skin infections (impetigo). Erysipelas and cellulitis are characterised by multiplication and lateral spread of Streptococcus pyogenes in deep layers of the skin...
November 9, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Marion Claudia Salzer, Atefeh Lafzi, Antoni Berenguer-Llergo, Catrin Youssif, Andrés Castellanos, Guiomar Solanas, Francisca Oliveira Peixoto, Camille Stephan-Otto Attolini, Neus Prats, Mònica Aguilera, Juan Martín-Caballero, Holger Heyn, Salvador Aznar Benitah
During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different dietary regimes that affect longevity. We show that the identity of old fibroblasts becomes undefined, with the fibroblast states present in young skin no longer clearly demarcated. In addition, old fibroblasts not only reduce the expression of genes involved in the formation of the extracellular matrix, but also gain adipogenic traits, paradoxically becoming more similar to neonatal pro-adipogenic fibroblasts...
November 3, 2018: Cell
Duck Soo Lim, Seul Min Choi, Kyu-Bong Kim, Kyungsil Yoon, Sam Kacew, Hyung Sik Kim, Byung-Mu Lee
Cutaneous allergy occurs primarily as a result of using cosmetic, household, and laundry products available on the market that contain fragrances. The aim of this study was to develop a rapid and specific high-performance liquid chromatography with ultraviolet detection (HPLC-UV) method for quantification of 25 fragrance allergens (amyl cinnamyl alcohol, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, citronellol, cinnamyl alcohol, citral, coumarin, eugenol, farnesol, geraniol, hydroxycitronellal, HICC (4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboaldehyde), isoeugenol, isoeugenyl acetate, lilial (butyl phenyl methyl propional), limonene, linalool, methyl 2-octynoate, etc...
November 12, 2018: Journal of Toxicology and Environmental Health. Part A
Felicity Ferguson, Korbkarn Pongpairoj, David A Basketter, Ian R White, John P McFadden
In the first conundrum, permanent hair dyeing uses aromatic amines such as p-phenylenediamine (PPD), whose oxidation is pivotal to the dyeing process, but also generates potent allergens. Despite prolonged industry effort searching for safer alternatives, hair dyeing is still reliant on this type of aromatic amine. In the second conundrum, patch testing with 1% PPD remains the most useful screen for hair dye contact allergy. However, there is a very small but real risk of actively sensitising the patient. Lowering the PPD concentration below 1% significantly reduces test sensitivity and diagnostic utility...
November 8, 2018: Contact Dermatitis
Sukhmanjot Kaur, Amal Narayanan, Siddhesh Dalvi, Qianhui Liu, Abraham Joy, Ali Dhinojwala
Marine organisms such as mussels have mastered the challenges in underwater adhesion by incorporating post-translationally modified amino acids like l-3,4-dihydroxyphenylalanine (DOPA) in adhesive proteins. Here we designed a catechol containing elastomer adhesive to identify the role of catechol in interfacial adhesion in both dry and wet conditions. To decouple the adhesive contribution of catechol to the overall adhesion, the elastomer was designed to be cross-linked through [2 + 2] photo-cycloaddition of coumarin...
October 24, 2018: ACS Central Science
Stephanie C Erdle, Edmond S Chan, Hyungjun Yang, Bruce A Vallance, Christopher Mill, Tiffany Wong
Background: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients...
2018: Allergy, Asthma, and Clinical Immunology
Patricia Froes Meyer, Julio Davi Costa E Silva, Liliane Santos de Vasconcellos, Eneida de Morais Carreiro, Rodrigo Marcel Valentim da Silva
Cryolipolysis is considered a safe and effective procedure, with high patient satisfaction rates, especially when compared to other procedures for localized adiposity, such as high-intensity focused ultrasound and shock waves. Although this statement is present in the literature, the importance of the selection of suitable patients for this type of treatment is not well known. The objective of this study was to discuss the criteria to be considered in the selection of patients who are candidates for cryolipolysis and assess their profile regarding their anthropometric data, age, skin characteristics, cutaneous sensitivity, and risk pathologies for this type of treatment...
2018: Clinical, Cosmetic and Investigational Dermatology
Fabrizio Spada, Tanya M Barnes, Kerryn A Greive
Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin. Materials and methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo...
2018: Clinical, Cosmetic and Investigational Dermatology
Inês P Santos, Remco van Doorn, Peter J Caspers, Tom C Bakker Schut, Elisa M Barroso, Tamar E C Nijsten, Vincent Noordhoek Hegt, Senada Koljenović, Gerwin J Puppels
BACKGROUND: Clinical diagnosis of early melanoma (Breslow thickness less than 0.8 mm) is crucial to disease-free survival. However, it is subjective and can be exceedingly difficult, leading to missed melanomas, or unnecessary excision of benign pigmented skin lesions. An objective technique is needed to improve the diagnosis of early melanoma. METHODS: We have developed a method to improve diagnosis of (thin) melanoma, based on Raman spectroscopy. In an ex vivo study in a tertiary referral (pigmented lesions) centre, high-wavenumber Raman spectra were collected from 174 freshly excised melanocytic lesions suspicious for melanoma...
November 9, 2018: British Journal of Cancer
Cheng Xu, Yu-Pei Chen, Xiao-Jing Du, Jin-Qi Liu, Cheng-Long Huang, Lei Chen, Guan-Qun Zhou, Wen-Fei Li, Yan-Ping Mao, Chiun Hsu, Qing Liu, Ai-Hua Lin, Ling-Long Tang, Ying Sun, Jun Ma
OBJECTIVE: To provide a complete toxicity profile, toxicity spectrum, and a safety ranking of immune checkpoint inhibitor (ICI) drugs for treatment of cancer. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) were systematically searched to include relevant studies published in English between January 2007 and February 2018. REVIEW METHODS: Only head-to-head phase II and III randomised controlled trials comparing any two or three of the following treatments or different doses of the same ICI drug were included: nivolumab, pembrolizumab, ipilimumab, tremelimumab, atezolizumab, conventional therapy (chemotherapy, targeted therapy, and their combinations), two ICI drugs, or one ICI drug with conventional therapy...
November 8, 2018: BMJ: British Medical Journal
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