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https://www.readbyqxmd.com/read/28102060/usefulness-of-house-dust-mite-nasal-provocation-test-in-asthma
#1
Inseon S Choi, Soo Jeong Kim, Joo Min Won, Myeong Soo Park
PURPOSE: We previously reported that the skin prick test was sensitive and the serum specific immunoglobulin E test was specific for predicting positive airway responses to house dust mites (HDMs) in patients with asthma. Because the nose and bronchus are one airway, the nasal provocation test would be more specific for predicting the bronchial responses to HDM than the skin test. METHODS: The allergy skin prick test and nasal and bronchial provocation tests using HDM (Dermatophagoides farinae) were performed in 41 young men (age, 19-28 years) who wanted military certification for asthma...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28101414/anti-confocal-assessment-of-middle-ear-inflammation
#2
David S Jung, John A Crowe, John P Birchall, Michael G Somekh, Chung W See
To improve the diagnostic prediction of recurrence of otitis media with effusion after surgery, an anti-confocal system combined with spectroscopic measurements is proposed to reject unwanted signals from the eardrum and assess the blood content. The anti-confocal system was experimentally evaluated on both optical middle ear phantom and human skin. Results showed effective rejection of signals from the eardrum using a central stop replacing the confocal pinhole, while still detecting signals from the middle ear mucosa...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28100039/low-dose-radiation-causes-skin-cancer-in-mice-and-has-a-differential-effect-on-distinct-epidermal-stem-cells
#3
Tatiana Revenco, Gaelle Lapouge, Virginie Moers, Sylvain Brohée, Panagiota A Sotiropoulou
The carcinogenic effect of ionizing radiation has been evaluated based on limited populations accidently exposed to high dose radiation. In contrast, insufficient data are available on the effect of low dose radiation, such as radiation deriving from medical investigations and interventions, as well as occupational exposure that concern a large fraction of western populations. Using mouse skin epidermis as a model, we showed that low dose radiation results in DNA damage in sebaceous gland and bulge epidermal stem cells (SCs)...
January 18, 2017: Stem Cells
https://www.readbyqxmd.com/read/28098454/high-sensitive-wearable-textile-based-humidity-sensor-made-of-high-strength-single-walled-carbon-nanotube-swcnt-poly-vinyl-alcohol-pva-filaments
#4
Gengheng Zhou, Joon-Hyung Byun, Youngseok Oh, Byung-Mun Jung, Hwa-Jin Cha, Dong Gi Seong, Moon-Kwang Um, Sangil Hyun, Tsu-Wei Chou
Textile-based humidity sensors can be an important component of smart wearable electronic-textiles and have potential applications in the management of wounds, bed-wetting, and skin pathologies or for microclimate control in clothing. Here, we report a wearable textile-based humidity sensor for the first time using high strength (~750 MPa) and ultra-tough (energy-to-break, 4300 J g-1) SWCNT/PVA filaments via a wet-spinning process. The conductive SWCNT networks in the filaments can be modulated by adjusting the intertube distance by swelling the PVA molecular chains via the absorption of water molecules...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28096610/investigation-of-body-and-udder-skin-surface-temperature-differentials-as-an-early-indicator-of-mastitis-in-holstein-friesian-crossbred-cows-using-digital-infrared-thermography-technique
#5
M Sathiyabarathi, S Jeyakumar, A Manimaran, Heartwin A Pushpadass, M Sivaram, K P Ramesha, D N Das, Mukund A Kataktalware, G Jayaprakash, Tapas Kumar Patbandha
AIM: The objective of this study was to investigate the ability of infrared thermography (IRT) technique and its interrelationship with conventional mastitis indicators for the early detection of mastitis in Holstein Friesian (HF) crossbred cows. MATERIALS AND METHODS: A total of 76 quarters of lactating HF crossbred (Bos indicus × Bos taurus) cows (n=19) were monitored for body temperature (i.e., eye temperature) and udder skin surface temperature (USST) before milking using forward-looking infrared (FLIR) i5 camera...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28095556/combination-therapy-for-acne-scarring-personal-experience-and-clinical-suggestions
#6
Lucija Kroepfl, Jason J Emer
Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28094871/divergence-of-camp-signaling-pathways-mediating-augmented-nucleotide-excision-repair-and-pigment-induction-in-melanocytes
#7
Erin M Wolf Horrell, Stuart G Jarrett, Katharine M Carter, John A D'Orazio
Loss-of-function melanocortin 1 receptor (MC1R) polymorphisms are common in UV-sensitive fair-skinned individuals and are associated with blunted cAMP second messenger signaling and higher lifetime risk of melanoma because of diminished ability of melanocytes to cope with UV damage. cAMP signaling positions melanocytes to resist UV injury by up-regulating synthesis of UV-blocking eumelanin pigment and by enhancing the repair of UV-induced DNA damage. cAMP enhances melanocyte nucleotide excision repair (NER), the genome maintenance pathway responsible for the removal of mutagenic UV photolesions, through cAMP-activated protein kinase (protein kinase A)-mediated phosphorylation of the ataxia telangiectasia mutated and Rad3 related (ATR) protein on the S435 residue...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28093314/remote-sensing-of-multiple-vital-signs-using-a-cmos-camera-equipped-infrared-thermography-system-and-its-clinical-application-in-rapidly-screening-patients-with-suspected-infectious-diseases
#8
Guanghao Sun, Yosuke Nakayama, Sumiyakhand Dagdanpurev, Shigeto Abe, Hidekazu Nishimura, Tetsuo Kirimoto, Takemi Matsui
BACKGROUND: Infrared thermography (IRT) is used to screen febrile passengers at international airports, but it suffers from low sensitivity. This study explored the application of a combined visible and thermal image processing approach that used a CMOS camera equipped with IRT to remotely sense multiple vital signs and screen patients with suspected infectious diseases. METHODS: An IRT system that produced visible and thermal images was used for image acquisition...
January 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28092944/reaction-chemistry-to-characterize-the-molecular-initiating-event-in-skin-sensitization-a-journey-to-be-continued
#9
Andreas Natsch, Roger Emter
The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger skin allergies. The molecular initiating event (MIE) in the AOP is reaction with skin peptides/proteins. It is followed by a number of cellular events. Currently, only one in chemico test to characterize the MIE was proposed to and underwent adoption by the OECD, while two cell-based assays have completed the process...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28091866/review-of-diagnostic-challenges-in-occupational-asthma
#10
REVIEW
Jacques A Pralong, Andre Cartier
PURPOSE OF REVIEW: Occupational asthma (OA) is one of the most frequent occupational diseases and its diagnosis is often difficult. This review summarizes its current diagnostic challenges. RECENT FINDINGS: OA is associated with significant health and socio-economic burden. It is underdiagnosed and physicians need to adopt a stepwise approach to confirm the diagnosis. Although early removal from exposure to the offending agent is associated with a better prognosis, physicians should try to confirm the diagnosis of work-related asthma before taking a worker off work...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28091699/musculoskeletal-mri-findings-of-juvenile-localized-scleroderma
#11
Eric P Eutsler, Daniel B Horton, Monica Epelman, Terri Finkel, Lauren W Averill
BACKGROUND: Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in addition to cosmetic changes. OBJECTIVE: There is literature documenting the spectrum of findings for deep involvement of localized scleroderma (fascia, muscles, tendons, bones and joints) in adults, but there is limited literature for the condition in children...
January 14, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28089728/internet-based-skin-cancer-screening-using-clinical-images-alone-or-in-conjunction-with-dermoscopic-images-a-randomized-teledermoscopy-trial
#12
Lara Ferrándiz, Teresa Ojeda-Vila, Araceli Corrales, Francisco J Martín-Gutiérrez, Andrés Ruíz-de-Casas, Rafael Galdeano, Ignacio Álvarez-Torralba, Francisco Sánchez-Ibáñez, José M Domínguez-Toro, Fernando Encina, Francisco J Narbona, Juan M Herrerías-Esteban, David Moreno-Ramírez
BACKGROUND: Teledermoscopy involves the use of dermoscopic images for remote consultation and decision-making in skin cancer screening. OBJECTIVE: We sought to analyze the potential benefits gained from the addition of dermoscopic images to an internet-based skin cancer screening system. METHODS: A randomized clinical trial assessed the diagnostic performance and cost-effectiveness of clinical teleconsultations (CTC) and clinical with dermoscopic teleconsultations...
January 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28088750/continuous-minimally-invasive-alcohol-monitoring-using-microneedle-sensor-arrays
#13
A M Vinu Mohan, Joshua Ray Windmiller, Rupesh K Mishra, Joseph Wang
The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire microtransducer, followed by the immobilization of alcohol oxidase (AOx) in an intermediate chitosan layer, along with an outer Nafion layer...
January 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28088483/physiology-recording-with-magnetic-field-probes-for-fmri-denoising
#14
Simon Gross, Laetitia Vionnet, Lars Kasper, Benjamin E Dietrich, Klaas P Pruessmann
Physiological noise originating in cardiovascular and respiratory processes is a substantial confound in BOLD fMRI. When unaccounted for it reduces the temporal SNR and causes error in inferred brain activity and connectivity. Physiology correction typically relies on auxiliary measurements with peripheral devices such as ECG, pulse oximeters, and breathing belts. These require direct skin contact or at least a tight fit, impairing subject comfort and adding to the setup time. In this work, we explore a touch-free alternative for physiology recording, using magnetic detection with NMR field probes...
January 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28086963/near-infrared-spectroscopy-for-body-fat-sensing-in-neonates-quantitative-analysis-by-gamos-simulations
#15
Fatin Hamimi Mustafa, Peter W Jones, Alistair L McEwan
BACKGROUND: Under-nutrition in neonates is closely linked to low body fat percentage. Undernourished neonates are exposed to immediate mortality as well as unwanted health impacts in their later life including obesity and hypertension. One potential low cost approach for obtaining direct measurements of body fat is near-infrared (NIR) interactance. The aims of this study were to model the effect of varying volume fractions of melanin and water in skin over NIR spectra, and to define sensitivity of NIR reflection on changes of thickness of subcutaneous fat...
January 11, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28081185/upregulated-expression-of-transient-receptor-potential-cation-channel-subfamily-v-receptors-in-mucosae-of-patients-with-oral-squamous-cell-carcinoma-and-patients-with-a-history-of-alcohol-consumption-or-smoking
#16
Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori
OBJECTIVES: Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substances, and changes in pH, and, notably, the risk factors for oncogenic transformation in oral squamous epithelium are the same as the external stimuli received by TRPV1-4 receptors...
2017: PloS One
https://www.readbyqxmd.com/read/28079705/prescribed-drinking-leads-to-better-cycling-performance-than-ad-libitum-drinking
#17
Costas N Bardis, Stavros A Kavouras, J D Adams, Nickos D Geladas, Demosthenis B Panagiotakos, Labros S Sidossis
: Drinking ad libitum during exercise often leads to dehydration ranging from -1 to -3% of body weight. PURPOSE: To study the effect of a prescribed hydration protocol matching fluid losses on a simulated 30-km criterium-like cycling performance in the heat (31.6±0.5 °C). METHOD: Ten elite, heat-acclimatized, male endurance cyclists (30±5 y, 76.5±7.2 kg, 1.81±0.07 m, VO2peak: 61.3±5.2 ml[BULLET OPERATOR]min[BULLET OPERATOR]kg, body fat: 10...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28079384/hypoxia-and-h2o2-dual-sensitive-vesicles-for-enhanced-glucose-responsive-insulin-delivery
#18
Jicheng Yu, Chenggen Qian, Yuqi Zhang, Zheng Cui, Yong Zhu, Qundong Shen, Frances S Ligler, John B Buse, Zhen Gu
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H2O2 dual-sensitive diblock copolymer, the glucose-responsive polymersome-based vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H2O2 and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme...
January 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28076469/scoring-clinical-signs-can-help-diagnose-canine-visceral-leishmaniasis-in-a-highly-endemic-area-in-brazil
#19
Kleverton Ribeiro da Silva, Vitor Rosa Ramos de Mendonça, Kellen Matuzzy Silva, Leopoldo Fabrício Marçal do Nascimento, Antonio Ferreira Mendes-Sousa, Flaviane Alves de Pinho, Manoel Barral-Netto, Aldina Maria Prado Barral, Maria do Socorro Pires E Cruz
Canine visceral leishmaniasis (CVL) diagnosis is still a challenge in endemic areas with limited diagnostic resources. This study proposes a score with the potential to distinguish positive CVL cases from negative ones. We studied 265 dogs that tested positive for CVL on ELISA and parasitological tests. A score ranging between 0 and 19 was recorded on the basis of clinical signs. Dogs with CVL had an overall higher positivity of the majority of clinical signs than did dogs without CVL or with ehrlichiosis. Clinical signs such as enlarged lymph nodes (83...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28076343/pigmented-basal-cell-carcinoma-mimicking-a-superficial-spreading-melanoma
#20
Paula Hasbún Acuña, Roberto Cullen Aravena, César Maturana Donaire, Raúl Ares Mora, Ninoska Porras Kusmanic
Basal cell carcinoma is the most common form of skin cancer, especially in elderly people. Pigmented basal cell carcinoma is a rare subtype and has been described in the literature as a nodular and hyperpigmented lesion; rarely, it can appear as an extensive pigmented plate, which may be clinically indistinguishable from superficial spreading melanoma and Bowen disease. Dermatoscopy has a high sensitivity in the diagnosis of basal cell carcinoma. When Menzies criteria are used; however, the final diagnosis is made by histopathology...
December 20, 2016: Medwave
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