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https://www.readbyqxmd.com/read/30025298/development-and-validation-of-a-simple-chromatographic-method-for-simultaneous-determination-of-clindamycin-phosphate-and-rifampicin-in-skin-permeation-studies
#1
Maira N Pereira, Breno N Matos, Tais Gratieri, Marcilio Cunha-Filho, Guilherme M Gelfuso
Rifampicin (RIF) and clindamycin phosphate (CDM) are the main drugs currently used in combination to treat severe infectious diseases in hair follicles. This work describes a simple, rapid and sensitive method for simultaneous analysis of RIF and CDM in the different skin layers using high performance liquid chromatography (HPLC). The efficient chromatographic separation of CDM and RIF was succeeded using a C18 column (150 mm x 4.6 mm, 5 μm) with gradient elution using a mobile phase composed of 0...
July 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30022978/mouse-model-established-by-early-renal-transplantation-after-skin-allograft-sensitization-mimics-clinical-antibody-mediated-rejection
#2
Daqiang Zhao, Tao Liao, Siwen Li, Yannan Zhang, Haofeng Zheng, Jing Zhou, Fei Han, Yu Dong, Qiquan Sun
Antibody-mediated rejection (AMR) is the main barrier to renal graft survival, and mouse renal AMR models are important to study this process. Current mouse models are established by priming the recipient to donor skin for over 7 days before kidney transplantation. The robustness of AMR in these cases is too strong to mimic clinical AMR and it is unclear why altering the priming times ranging from 7 to 91 days fails to reduce the AMR potency in these models. In the present study, we found that the donor-recipient combination and skin graft size were determinants of donor-specific antibody (DSA) development patterns after skin transplantation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30022845/a-novel-animal-model-for-residence-time-evaluation-of-injectable-hyaluronic-acid-based-fillers-using-high-frequency-ultrasound-based-approach
#3
Filomena Merola, Mario Scrima, Carmela Melito, Antonio Iorio, Claudio Pisano, Andrea Maria Giori, Angela Ferravante
Background: Hyaluronic acid (HA)-based devices are among the most popular filler agents for skin rejuvenation. One of the principal goals is the improvement in residence time of HA-based products, to increase their performance and reduce frequency of the treatment. So, understanding fillers, behavior after subcutaneous injection is a fundamental aspect for discovery and optimization of new products. Current in vivo approaches to detect/quantify injected HA fillers are not always well optimized or easy to apply...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30022595/effect-of-a-botanical-cleansing-lotion-on-skin-sebum-and-erythema-of-the-face-a-randomized-controlled-blinded-half-side-comparison
#4
Natalja Weber, Kay Schwabe, Christoph M Schempp, Ute Wölfle
BACKGROUND: Elevated levels of skin sebum are associated with the growth of Propionibacterium acnes. Intensive degreasing of the skin reduces Propionibacterium acnes but also may cause skin irritation. AIMS: We assessed the degreasing effect and skin tolerability of a botanical face cleanser with hops and willow bark extract and disodium cocoyl glutamate as mild cleansing agent compared to a standard face cleanser with sodium laureth sulfate (SLES). MATERIALS AND METHODS: A total of 21 healthy volunteers with normal to oily skin were enrolled in this study...
July 18, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/30022546/development-and-validation-of-a-new-tool-to-assess-the-burden-of-sensitive-skin-boss
#5
L Misery, E Jourdan, S Abadie, K Ezzedine, E Brenaut, F Huet, M Sayag, C Taieb
BACKGROUND: Sensitive skin usually manifests itself as unpleasant sensations and sometimes erythema. There are various triggering factors for this condition. Although sensitive skin may alter quality of life, its burden has not yet been explored. OBJECTIVE: The aim of this study was to develop and validate a specific sensitive skin burden questionnaire called the BoSS (Burden of Sensitive Skin). METHODS: A conceptual phase was developed, followed by a development phase, external validation, psychometric analysis, test-retest analysis and, finally, a translation, cross-cultural adaptation and cognitive debriefing...
July 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30022542/biofilm-production-and-antibiotic-susceptibility-of-staphylococcus-epidermidis-strains-from-hidradenitis-suppurativa-lesions
#6
C B Ardon, E P Prens, K Fuursted, R N Ejaz, J Shailes, H Jenssen, G B E Jemec
BACKGROUND: An aberrant interaction between commensal skin bacteria and the host skin immune system is considered important in the pathogenesis of Hidradenitis Suppurativa (HS). OBJECTIVE: In this study we investigated the antibiotic susceptibility and biofilm-forming capabilities of S. epidermidis strains isolated from HS patients. METHODS: Skin biopsies were taken from active HS lesions such as inflammatory nodules and/or sinuses and non-involved skin from 26 patients and cultured under optimal microbiological conditions for 24 hours...
July 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30021804/photosensitivity-and-type-i-ifn-responses-in-cutaneous-lupus-are-driven-by-epidermal-derived-interferon-kappa
#7
Mrinal K Sarkar, Grace A Hile, Lam C Tsoi, Xianying Xing, Jianhua Liu, Yun Liang, Celine C Berthier, William R Swindell, Matthew T Patrick, Shuai Shao, Pei-Suen Tsou, Ranjitha Uppala, Maria A Beamer, Anshika Srivastava, Stephanie L Bielas, Paul W Harms, Spiro Getsios, James T Elder, John J Voorhees, Johann E Gudjonsson, J Michelle Kahlenberg
OBJECTIVE: Skin inflammation and photosensitivity are common in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known about the mechanisms that regulate these traits. Here we investigate the role of interferon kappa (IFN-κ) in regulation of type I interferon (IFN) and photosensitive responses and examine its dysregulation in lupus skin. METHODS: mRNA expression of type I IFN genes was analysed from microarray data of CLE lesions and healthy control skin...
July 18, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30021726/aspirin-suppresses-pge-2-and-activates-amp-kinase-to-inhibit-melanoma-cell-motility-pigmentation-and-selective-tumor-growth-in-vivo
#8
Douglas Grossman, Dileep Kumar, Hafeez Rahman, Ethika Tyagi, Tong Liu, Chelsea Li, Ran Lu, David Lum, Sheri L Holmen, John A Maschek, James E Cox, Matthew W VanBrocklin
There are conflicting epidemiologic data on whether chronic aspirin (ASA) use may reduce melanoma risk in humans. Potential anti-cancer effects of ASA may be mediated by its ability to suppress prostaglandin E2 (PGE2) production and activate 5'-adenosine monophosphate-activated protein kinase (AMPK). We investigated the inhibitory effects of ASA in a panel of melanoma and transformed melanocyte cell lines, and on tumor growth in a preclinical model. ASA and the COX-2 inhibitor Celecoxib did not affect melanoma cell viability, but significantly reduced colony formation, cell motility, and pigmentation (melanin production) in vitro at concentrations of 1 mM and 20 uM, respectively...
July 18, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30020862/il-1%C3%AE-and-il-1%C3%AE-as-alternative-biomarkers-for-risk-assessment-and-the-prediction-of-skin-sensitization-potency
#9
Min Kook Kim, Kyu-Bong Kim, Kyungsil Yoon, Sam Kacew, Hyung Sik Kim, Byung-Mu Lee
Potential biomarkers of skin sensitization in RAW264.7 mouse macrophages were investigated as alternatives to animal experiments and risk assessment. The concentrations that resulted in a cell viability of 90% (CV90) and 75% (CV75) were calculated by using a water-soluble tetrazolium salt (WST)-1 assay and used to analyze the skin sensitization potency of 23 experimental materials under equivalent treatment conditions. In addition, the expression of interleukin (IL)-1α, IL-1β, IL-31, tumor necrosis factor (TNF)-α, inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2) was analyzed utilizing Western blotting...
July 18, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30019145/topical-antimicrobial-prophylaxis-in-colorectal-surgery-for-the-prevention-of-surgical-wound-infection-a-systematic-review-and-meta-analysis
#10
REVIEW
R L Nelson, A Kravets, R Khateeb, M Raza, M Siddiqui, I Taha, A Tummala, R Epple, S Huang, M Wen
BACKGROUND: Among the techniques investigated to reduce the risk of surgical wound infection or surgical space infection (SSI) in patients having colorectal surgery are topical application of antimicrobials (antibiotics and antiseptics) to the open wound or immediately after closure. The aim of the present study was to perform a systematic review of the literature on those treatments, with the exception of antibiotic ointments applied to closed skin, which are adequately assessed elsewhere, and a meta-analysis...
July 17, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/30018635/dietary-habits-in-patients-with-chronic-spontaneous-urticaria-evaluation-of-food-as-trigger-of-symptoms-exacerbation
#11
Jorge Sánchez, Andres Sánchez, Ricardo Cardona
Background: Many patients with chronic spontaneous urticaria (CSU) identify different foods as triggers of their symptoms and frequently make dietary restrictions without enough information. Objective: To explore the diet habits of CSU patients and estimate the clinical impact of the foods most frequently reported to be suspect. Methodology: Patients were interrogated about their clinical history of urticaria. Skin prick test and sIgE serum were done for most frequently reported foods by patients...
2018: Dermatology Research and Practice
https://www.readbyqxmd.com/read/30017215/the-relationship-between-nurses-assessment-of-early-pressure-ulcer-damage-and-sub-epidermal-moisture-measurement-a-prospective-explorative-study
#12
Gillian O'Brien, Zena Moore, Declan Patton, Tom O'Connor
AIM: To explore the relationship between nurses' visual assessment of early pressure ulceration and assessment using sub epidermal moisture measurement (a measure of skin and tissue water). MATERIALS AND METHODS: A descriptive prospective observational study design was employed. Following ethical approval and written informed consent, data were collected daily, for four weeks, from at risk patients within an acute care facility in Ireland. Data included nurses documented assessment of the patient's skin condition and researcher led sub epidermal moisture measurement, over the sacrum and both heels...
June 25, 2018: Journal of Tissue Viability
https://www.readbyqxmd.com/read/30017214/how-molecular-diagnosis-may-modify-immunotherapy-prescription-in-multi-sensitized-pollen-allergic-children
#13
Genoveva Del-Río Camacho, Ana María Montes Arjona, José Fernández-Cantalejo Padial, Rodríguez Catalán Jesús
INTRODUCTION: Specific immunotherapy (SIT) is used to treat asthma and allergic rhinitis, and a dose-response relationship has been found for SIT efficacy, creating a need to accurately select the allergen used in therapy. This need is especially pronounced in poly-sensitized children living in areas where different pollen allergen sources coexist in the same season, as this circumstance complicates diagnostic efforts. In such cases, component-resolved diagnosis (CRD) can increase diagnostic accuracy and aid in SIT prescription...
July 12, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/30017080/mycobacterium-avium-complex-infection-in-pigs-a-review
#14
REVIEW
Nikola Hulinova Stromerova, Martin Faldyna
Mycobacterial infections in pigs are caused particularly by the Mycobacterium avium complex (MAC) and these infections lead to great economic losses mainly within the countries with high pork meat production. The importance of the MAC infections in humans is rising because of its higher prevalence and also higher mortality rates particularly in advanced countries. In addition, treatment of the MAC infections in humans tends to be complicated because of its increasing resistance to antimicrobial agents. Several studies across Europe have documented the MAC occurrence in the slaughtered pigs - not only in their lymph nodes and tonsils, which are the most frequent, but also in the diaphragmas, other organs and not least in meat...
April 2018: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/30016760/assessing-off-target-cytotoxicity-of-the-field-lampricide-3-trifluoromethyl-4-nitrophenol-using-novel-lake-sturgeon-cell-lines
#15
Nguyen T K Vo, Levi C Moore, Katelin W Spiteri, Robert Hanner, Michael P Wilkie, Stephanie J DeWitte-Orr
Lampricides are currently being applied to streams and rivers to control the population of sea lamprey, an invasive species, in the Great Lakes. The most commonly used lampricide agent used in the field is 3-trifluoromethyl-4-nitrophenol (TFM), which targets larval sea lamprey in lamprey-infested rivers and streams. The specificity of TFM is due to the relative inability of sea lamprey to detoxify the agent relative to non-target fishes. There is increasing concern, however, about non-target effects on fishes, particularly threatened populations of juvenile lake sturgeon (LS; Acipenser fulvescens)...
July 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30016026/ischemia-modified-albumin-levels-in-children-with-asthma-a-pilot-study
#16
Mahmut Dogru, Handan Akoglu, Muhammet F Kilinckaya, Gozde Ulfer
INTRODUCTION: Hypoxia may occur in the severe exacerbations of asthma. Ischemia-modified albumin (IMA) may increase in ischemia, in addition to oxidative stress and inflammation. The aim was to evaluate IMA levels in children during the asthma exacerbation and the asymptomatic period. POPULATION AND METHODS: Children with asthma who were followed up in our clinic were included and healthy children were selected as the control group. The severity of exacerbation was evaluated with Global Initiative for Asthma and Modified Pulmonary Index Score...
August 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/30014821/operational-performance-of-the-onchocerca-volvulus-oepa-ov16-elisa-serological-assay-in-mapping-stop-mass-drug-administration-and-posttreatment-surveillance-surveys
#17
Frank O Richards, Moses Katabarwa, Firdaweke Bekele, Zerihun Tadesse, Aderajew Mohammed, Mauricio Sauerbrey, Alfredo Dominguez-Vazquez, Mario A Rodriguez-Perez, Nadia A Fernández-Santos, Nidia Rizzo, Harland R Schuler Martínez, Raquel Lovato Silva, Zoraida Morales Monroy, Peace Habomugisha, David W Oguttu, Issam M A Zarroug, Nabil A Aziz, Thomas R Unnasch
Onchocerciasis is a neglected tropical disease targeted for elimination. The World Health Organization (WHO) has developed guidelines for the verification of onchocerciasis elimination that include entomological and epidemiological criteria. The latter require demonstrating with statistical confidence that the infection prevalence in children is less than 0.1%, necessitating an assay with a high degree of specificity. We present an analysis of the performance of the Onchocerciasis Elimination Program for the Americas (OEPA) version of the Ov16 ELISA when used under operational conditions...
July 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30014650/-quantitative-assessment-of-skin-thickness-using-high-frequency-ultrasound-in-systemic-sclerosis
#18
Si Sun, Yu-Jia Yang, Li-Yun Wang, Yuan-Jiao Tang, Li Qiu, Bai-Hai Su
OBJECTIVE: To investigate the performance of high frequency ultrasound in the assessment of skin thickness in patients with systemic sclerosis (SSc). METHODS: The study included 82 SSc (SSc group) and 67 healthy volunteers (control group) from 2014 to 2016. The skin thickness at bilateral middle fingers and forearms,anterior chest and abdominal wall was measured using high frequency ultrasound. All the patients with SSc underwent the modified rodnan skin score (mRSS) over 17 anatomical sites by an experienced dermatologist...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/30013973/a-perspective-on-the-use-of-nb-uvb-phototherapy-vs-puva-photochemotherapy
#19
Sally H Ibbotson
Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases. The main indication for NB-UVB and PUVA therapies is psoriasis, and other key diagnoses include atopic eczema, vitiligo, cutaneous T-cell lymphoma (CTCL), and the photodermatoses. The decision on choice of phototherapy is important and NB-UVB is usually the primary choice. NB-UVB phototherapy is a safe and effective therapy which is usually considered when topical agents have failed...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30013275/oral-intake-of-lactobacillus-helveticus-ns8-alleviates-ovalbumin-induced-atopic-dermatitis-in-skh-1-hairless-mice
#20
Jingjing Rong, Shuzhan Liu, Chao Hu, Feng Jin, Li Wang
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and is driven by strong type 2 immune responses. Lactobacillus helveticus NS8 (NS8), a probiotic strain isolated from Mongolian koumiss, has anti-inflammatory activities. Here, we evaluated the therapeutic potential of NS8 on AD-like skin lesions by using SKH-1 hairless mice that underwent three cycles of epicutaneous sensitization (EC) with ovalbumin (OVA). NS8 (5 × 108 CFU/day) was orally administered to mice from 2 weeks before the first sensitization until the end of the study...
September 2018: Indian Journal of Microbiology
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