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Selective digestive decontamination

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https://www.readbyqxmd.com/read/28348791/successful-treatment-of-recurrent-helicobacter-fennelliae-bacteraemia-by-selective-digestive-decontamination-with-kanamycin-in-a-lung-cancer-patient-receiving-chemotherapy
#1
Yoshihiro Fujiya, Maki Nagamatsu, Junko Tomida, Yoshiaki Kawamura, Kei Yamamoto, Momoko Mawatari, Satoshi Kutsuna, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Kazuhisa Mezaki, Masao Hashimoto, Satoru Ishii, Norio Ohmagari
INTRODUCTION: Helicobacter fennelliae is an enterohepatic Helicobacter species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent H. fennelliae bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for H. fennelliae infection. CASE PRESENTATION: H. fennelliae bacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy for Helicobactercinaedi bacteraemia...
October 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28267670/selective-digestive-decontamination-in-critically-ill-children-a-survey-of-canadian-providers
#2
Srinivas Murthy, Nazima Pathan, Brian H Cuthbertson
BACKGROUND: Selective digestive decontamination of the digestive tract involves the routine administration of oral, gastric, and intravenous antibiotics to mechanically ventilated children to prevent hospital-acquired infections. It has a strong evidence base in adults, with limited pediatric evidence. Current utilization of this intervention among pediatric physicians in North America is unknown. METHODS: An electronic survey administered to pediatric critical care and pediatric infectious disease providers in Canada...
June 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/27858411/increasing-intensity-of-selective-digestive-decontamination-sdd-dosing-does-not-result-in-improved-clinical-outcomes
#3
Johanna M Pieterse, Dinis Dos Reis Miranda, Wim Rietdijk, Jan Bakker
No abstract text is available yet for this article.
November 18, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27755474/selective-digestive-decontamination-attenuates-organ-dysfunction-in-critically-ill-burn-patients
#4
Lucía López-Rodríguez, Miguel A de la Cal, Paloma García-Hierro, Raquel Herrero, Judith Martins, Hendrick K F van Saene, José A Lorente
OBJECTIVE: To evaluate whether selective decontamination of the digestive tract (SDD) attenuates organ dysfunction in critically ill burn patients. BACKGROUND: The effect of SDD on the development and progression of organ dysfunction, as an important determinant of mortality in burned patients, is still unknown. We asked whether organ dysfunction is mitigated by treatment with SDD. METHODS: Patients with burns >20% of total body surface or suspected inhalation injury from a randomized placebo-controlled trial were analyzed to determine the relationship between treatment received (placebo or SDD) and the severity of organ dysfunction as measured by the area under the curve of the Sequential Organ Failure Assessment (SOFA) score (and its individual components) from day 1 to day 7 of admission...
November 2016: Shock
https://www.readbyqxmd.com/read/27600049/genomic-characterization-of-colistin-heteroresistance-in-klebsiella-pneumoniae-during-a-nosocomial-outbreak
#5
Teysir Halaby, Emre Kucukkose, Axel B Janssen, Malbert R C Rogers, Dennis J Doorduijn, Adri G M van der Zanden, Nashwan Al Naiemi, Christina M J E Vandenbroucke-Grauls, Willem van Schaik
Klebsiella pneumoniae is emerging as an important nosocomial pathogen due to its rapidly increasing multidrug resistance, which has led to a renewed interest in polymyxin antibiotics, such as colistin, as antibiotics of last resort. However, heteroresistance (i.e., the presence of a subpopulation of resistant bacteria in an otherwise susceptible culture) may hamper the effectiveness of colistin treatment in patients. In a previous study, we showed that colistin resistance among extended-spectrum-beta-lactamase (ESBL)-producing K...
November 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27584588/reducing-the-impact-of-carbapenem-resistant-enterobacteriaceae-on-vulnerable-patient-groups-what-can-be-done
#6
Gökhan Metan, Murat Akova
PURPOSE OF REVIEW: Carbapenem-resistant Enterobacteriaceae (CRE) is a worldwide challenge and associated with a high mortality rate in critically ill patients. This review focused on rapid diagnosis, optimization of antimicrobial therapy, and implication of effective infection control precautions to reduce impact of CRE on vulnerable patients. RECENT FINDINGS: Several new diagnostic assays have recently been described for the early diagnosis of CRE. Retrospective studies are supportive for colistin plus meropenem combination for the treatment of CRE infections; however, solid evidence is still lacking...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27533048/an-outbreak-of-clostridium-difficile-ribotype-027-associated-with-length-of-stay-in-the-intensive-care-unit-and-use-of-selective-decontamination-of-the-digestive-tract-a-case-control-study
#7
Yvette H van Beurden, Olaf M Dekkers, Marije K Bomers, Annie M Kaiser, Robin van Houdt, Cornelis W Knetsch, Armand R J Girbes, Chris J J Mulder, Christina M J E Vandenbroucke-Grauls
BACKGROUND: An outbreak of Clostridium difficile ribotype 027 infection (CDI) occurred at an university hospital, involving 19 departments. To determine what hospital-associated factors drove the outbreak of this particular strain we performed a case-control study. METHODS: Cases (n = 79), diagnosed with CDI due to C. difficile ribotype 027 were matched for age and treating medical specialty to four control patients (n = 316). Patients diagnosed with CDI due to other ribotypes were included as a second control group...
2016: PloS One
https://www.readbyqxmd.com/read/27488086/is-selective-digestive-decontamination-useful-for-critically-ill-patients
#8
Alexandre Biasi Cavalcanti, Thiago Lisboa, Ana Cristina Gales
In this study we review the rationale for using selective digestive decontamination (SDD) in critically ill patients, and its effects on clinical outcomes and rates of infection with antimicrobial-resistant microorganisms. SDD consists of the application of nonabsorbable antibiotics to the oropharynx and through a nasogastric or nasoenteral tube, in association with a 4-day course of an intravenous third-generation cephalosporin. The enteral component aims at preventing oral and rectal colonization with potentially pathogenic nosocomial aerobic gram-negative bacilli and yeasts while preserving normal protective anaerobic enteral flora...
January 2017: Shock
https://www.readbyqxmd.com/read/27436386/rifaximin-combined-with-polymyxins-a-potential-regimen-for-selective-decontamination-of-multidrug-resistant-bacteria-in-the-digestive-tract
#9
J W Betts, L M Phee, D W Wareham
Selective decontamination of the digestive tract (SDD) using combinations of oral non-absorbable antibiotics has been proposed as a means of preventing multidrug-resistant (MDR) infections. The minimum inhibitory concentrations (MICs) of rifaximin (RIFAX) were determined against 262 Gram-negative and Gram-positive bacterial isolates by broth microtitre assay. Rifampicin (RIF) was used as a comparator in the analysis. Synergistic interactions between RIFAX and polymyxin B (PMB) were assessed by using the chequerboard method and calculating the fractional inhibitory concentration index (FICI)...
March 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27391331/tlr4-deficiency-protects-against-hepatic-fibrosis-and-diethylnitrosamine-induced-pre-carcinogenic-liver-injury-in-fibrotic-liver
#10
Susanne Nicole Weber, Annika Bohner, Dianne H Dapito, Robert F Schwabe, Frank Lammert
BACKGROUND: The development of hepatocellular carcinoma (HCC) is a common consequence of advanced liver fibrosis but the interactions between fibrogenesis and carcinogenesis are still poorly understood. Recently it has been shown that HCC promotion depends on Toll-like receptor (TLR) 4. Pre-cancerogenous events can be modelled in mice by the administration of a single dose of diethylnitrosamine (DEN), with HCC formation depending amongst others on interleukin (IL) 6 production. Mice lacking the hepatocanalicular phosphatidylcholine transporter ABCB4 develop liver fibrosis spontaneously, resemble patients with sclerosing cholangitis due to mutations of the orthologous human gene, and represent a valid model to study tumour formation in pre-injured cholestatic liver...
2016: PloS One
https://www.readbyqxmd.com/read/27295062/erratum-to-comparison-of-the-evolution-of-mechanical-ventilation-associated-pneumonia-vap-before-the-implantation-of-selective-digestive-decontamination-dds-and-after-implantation-of-pneumonia-zero-program-nz
#11
R Fernández Fernández, M Herreros Gonzalo, L Serrano Fernández, L Camacho Peinado, N Cruza Leganés, M Á Taberna Izquierdo, F Alba García, F Árbol Linde
No abstract text is available yet for this article.
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290284/comparison-of-the-evolution-of-mechanical-ventilation-associated-pneumonia-vap-before-the-implantation-of-selective-digestive-decontamination-dds-and-after-implantation-of-pneumonia-zero-program-nz
#12
R Fernández Fernández, L Serrano Fernández, L Camacho Peinado, M Herreros Gonzalo, N Cruza Leganés, M Á Taberna Izquierdo, F Alba García, F Árbol Linde
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290283/impact-of-implementation-of-a-ventilator-associated-pneumonia-prevention-bundle-that-includes-selective-digestive-decontamination-in-a-southern-region-of-spain
#13
S Rebollo, R Jiménez, A Ortín, E Andreu, B Gil, M A López, M Royo-Villanova, L Capilla, J J Rodríguez, A Martínez-Pellús
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290282/effects-of-reintubation-on-ventilator-associated-nosocomial-pneumonias-incidence-in-icu-patients-with-versus-without-selective-digestive-decontamination
#14
A M Marrero-Rodríguez, E R Argandoña-Primicia, M E Gallardo-Santos, P Juárez-San Juan, C F Lübbe-Vazquez, J J Díaz Díaz, P Saavedra, S Ruiz-Santana
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27289725/evaluation-of-antibiotic-treatment-and-antibiotic-de-escalation-in-a-intensive-care-unit-with-selective-digestive-decontamination
#15
C Sánchez Ramirez, L Caipe Balcázar, S Hípola Escalada, M A Hernández Viera, M Cabrera Santana, N Sangil Monroy, A Bordes Benitez, P Saavedra Santana, S Ruiz Santana
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27289611/patients-colonization-and-infection-in-wards-after-discharge-from-a-polyvalent-intensive-care-unit-with-selective-digestive-decontamination-preliminary-results
#16
C Sánchez Ramirez, R Prada Osorio, C F Lübbe Vazquez, R Argandoña Primicia, J Cabrera Arrocha, F Artiles Campelo, S Ruiz Santana
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27289605/three-years-application-of-selective-digestive-decontamination-in-a-mixed-intensive-care-unit-in-a-university-hospital-impact-on-colonization-infection-and-antibiotic-consumption
#17
C Sánchez Ramirez, M Cabrera Santana, M A Hernández Viera, S Hípola Escalada, L Caipe Balcázar, N Sangil Monroy, A Bordes Benitez, F Artiles Campelo, P Saavedra Santana, S Ruiz Santana
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27116009/impact-of-selective-digestive-decontamination-on-respiratory-tract-candida-among-patients-with-suspected-ventilator-associated-pneumonia-a-meta-analysis
#18
J C Hurley
The purpose here is to establish the incidence of respiratory tract colonization with Candida (RT Candida) among ICU patients receiving mechanical ventilation within studies in the literature. Also of interest is its relationship with candidemia and the relative importance of topical antibiotic (TA) use as within studies of selective digestive decontamination (SDD) versus other candidate risk factors towards it. The incidence of RT Candida was extracted from component (control and intervention) groups decanted from studies of various TA and non-TA ICU infection prevention methods with summary estimates derived using random effects...
July 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27013315/infections-in-critically-ill-burn-patients
#19
F Hidalgo, D Mas, M Rubio, P Garcia-Hierro
Severe burn patients are one subset of critically patients in which the burn injury increases the risk of infection, systemic inflammatory response and sepsis. The infections are usually related to devices and to the burn wound. Most infections, as in other critically ill patients, are preceded by colonization of the digestive tract and the preventative measures include selective digestive decontamination and hygienic measures. Early excision of deep burn wound and appropriate use of topical antimicrobials and dressings are considered of paramount importance in the treatment of burns...
April 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/26817630/decolonization-in-prevention-of-health-care-associated-infections
#20
REVIEW
Edward J Septimus, Marin L Schweizer
Colonization with health care-associated pathogens such as Staphylococcus aureus, enterococci, Gram-negative organisms, and Clostridium difficile is associated with increased risk of infection. Decolonization is an evidence-based intervention that can be used to prevent health care-associated infections (HAIs). This review evaluates agents used for nasal topical decolonization, topical (e.g., skin) decolonization, oral decolonization, and selective digestive or oropharyngeal decontamination. Although the majority of studies performed to date have focused on S...
April 2016: Clinical Microbiology Reviews
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