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Lynne maxwell

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https://www.readbyqxmd.com/read/28507124/thiophene-antibacterials-that-allosterically-stabilize-dna-cleavage-complexes-with-dna-gyrase
#1
Pan F Chan, Thomas Germe, Benjamin D Bax, Jianzhong Huang, Reema K Thalji, Eric Bacqué, Anna Checchia, Dongzhao Chen, Haifeng Cui, Xiao Ding, Karen Ingraham, Lynn McCloskey, Kaushik Raha, Velupillai Srikannathasan, Anthony Maxwell, Robert A Stavenger
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyrase by stabilizing DNA-cleavage complexes, but their clinical utility has been compromised by resistance. We have identified a class of antibacterial thiophenes that target DNA gyrase with a unique mechanism of action and have activity against a range of bacterial pathogens, including strains resistant to fluoroquinolones...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28449302/prescribing-safety-assessment-2016-delivery-of-a-national-prescribing-assessment-to-7-343-uk-final-year-medical-students
#2
Simon R J Maxwell, Jamie J Coleman, Lynne Bollington, Celia Taylor, David J Webb
AIM(S): Newly graduated doctors write a large proportion of prescriptions in UK hospitals but recent studies have shown that they frequently make prescribing errors. The Prescribing Safety Assessment (PSA) has been developed as an assessment of competence in relation to prescribing and supervising the use of medicines. This report describes the delivery of the PSA to all UK final-year medical students in 2016 (PSA2016). METHODS: The PSA is a 2-hour online assessment comprising eight sections which cover various aspects of prescribing defined within the outcomes of undergraduate education identified by the UK General Medical Council...
April 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28300512/the-hypnotic-induction-in-the-broad-scheme-of-hypnosis-a-sociocognitive-perspective
#3
REVIEW
Steven Jay Lynn, Reed Maxwell, Joseph P Green
Researchers and clinicians typically divide hypnosis into two distinct parts: the induction and the suggestions that follow. We suggest that this distinction is arbitrary and artificial. Different definitions of hypnosis ascribe different roles to the hypnotic induction, yet none clearly specifies the mechanisms that mediate or moderate subjective and behavioral responses to hypnotic suggestions. Researchers have identified few if any differences in responding across diverse hypnotic inductions, and surprisingly little research has focused on the specific ingredients that optimize responsiveness...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28281916/prevalence-and-correlates-of-arrests-or-stops-for-drunk-driving-on-both-sides-of-the-u-s-mexico-border
#4
Lynn Wallisch, Sarah E Zemore, Guilherme Borges, Cheryl J Cherpitel, Jane C Maxwell
Risk for driving under the influence of alcohol (DUI) may be higher in U.S. and Mexico border cities as compared to nonborder cities in each country. We examine rates and correlates of self-reported DUI arrests or stops on both sides of the border, drawing on a large-scale survey of 4,796 Mexicans and Mexican Americans in border and nonborder cities of Texas and two states in Mexico. Findings varied by site and country and did not consistently show higher rates on the border. DUI prevention efforts should consider the heterogeneity of local conditions and needs...
March 10, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28238214/self-reported-substance-use-in-iraq-findings-from-the-iraqi-national-household-survey-of-alcohol-and-drug-use-2014
#5
Nesif Al-Hemiery, Rufaidah Dabbagh, Mushtaq T Hashim, Salih Al-Hasnawi, Ali Abutiheen, Emad A Abdulghani, Jawad K Al-Diwan, Neeraj Kak, Hala AlMossawi, Jane Carlisle Maxwell, Mary-Lynn Brecht, Valerie Antonini, Albert Hasson, Richard A Rawson
AIMS: To estimate the prevalence of tobacco, alcohol, and drug use in Iraq using data from the Iraqi National Household Survey of Alcohol and Drug Use (INHSAD). DESIGN: A cross-sectional survey was conducted using a multi-stage cluster sampling method. Trained surveyors conducted face-to-face household interviews. SETTING: Iraq, from April 2014 to December 2014. PARTICIPANTS: 3,200 adult, non-institutionalized Iraqi citizens residing across all 18 governorates of Iraq...
February 26, 2017: Addiction
https://www.readbyqxmd.com/read/28062336/comparative-safety-of-morphine-delivered-via-intravenous-route-vs-patient-controlled-analgesia-device-for-pediatric-inpatients
#6
Jennifer Faerber, Wenjun Zhong, Dingwei Dai, Avi Baehr, Lynne G Maxwell, Francis Wickham Kraemer, Chris Feudtner
CONTEXT: Although patient-controlled analgesia (PCA) is an effective pain control modality, there is a lack of large studies on PCA safety in pediatric patients. OBJECTIVES: This study compared the delivery of morphine either via intravenous route (morphine IV) or via PCA device (morphine PCA) on risk of cardiopulmonary resuscitation (CPR) and mechanical ventilation (MV) using a large administrative database. METHODS: We assembled a retrospective cohort of pediatric inpatients between five and 21 years old in 42 children's hospitals between 2007 and 2011 from the Pediatric Health Information System database...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27768675/optimal-timing-of-surgical-procedures-in-pediatric-patients
#7
Riva R Ko, Teeda Pinyavat, Steven Stylianos, Sarah M Lambert, Richard C Anderson, Pamela F Gallin, Lynne G Maxwell, Christopher G Ward, Jayant K Deshpande, Constance S Houck
The Pediatric Anesthesia Neuro Development Assessment (PANDA) team at the Anesthesiology Department at Columbia University Medical Center held its fifth biennial symposium to discuss issues regarding potential neurotoxicity of anesthetic agents in pediatric patients. Overall optimal surgical timing as well as a "critical window" for surgery on a specialty specific basis are areas of focus for the American Academy of Pediatrics Surgical Advisory Panel. An ad hoc panel of pediatric surgical experts representing general surgery, urology, neurosurgery, and ophthalmology was assembled for this meeting and provided a dialogue focused on the benefits of early intervention versus potential anesthetic risk, addressing parental concerns, and the need for continued interdisciplinary collaboration in this area...
October 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/27532251/neonatal-anesthesia
#8
Stephanie A Black, Lynne G Maxwell
No abstract text is available yet for this article.
September 2016: Anesthesiology
https://www.readbyqxmd.com/read/27477769/visual-function-of-moderately-hyperopic-4-and-5-year-old-children-in-the-vision-in-preschoolers-hyperopia-in-preschoolers-study
#9
MULTICENTER STUDY
Elise B Ciner, Marjean Taylor Kulp, Maureen G Maguire, Maxwell Pistilli, T Rowan Candy, Bruce Moore, Gui-Shuang Ying, Graham Quinn, Gale Orlansky, Lynn Cyert
PURPOSE: To compare visual performance between emmetropic and uncorrected moderately hyperopic preschool-age children without strabismus or amblyopia. DESIGN: Cross-sectional study. METHODS: setting: Multicenter, institutional. patient or study population: Children aged 4 or 5 years. intervention or observation procedures: Visual functions were classified as normal or reduced for each child based on the 95% confidence interval for emmetropic individuals...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27272582/association-between-a-single-general-anesthesia-exposure-before-age-36-months-and-neurocognitive-outcomes-in-later-childhood
#10
MULTICENTER STUDY
Lena S Sun, Guohua Li, Tonya L K Miller, Cynthia Salorio, Mary W Byrne, David C Bellinger, Caleb Ing, Raymond Park, Jerilynn Radcliffe, Stephen R Hays, Charles J DiMaggio, Timothy J Cooper, Virginia Rauh, Lynne G Maxwell, Ahrim Youn, Francis X McGowan
IMPORTANCE: Exposure of young animals to commonly used anesthetics causes neurotoxicity including impaired neurocognitive function and abnormal behavior. The potential neurocognitive and behavioral effects of anesthesia exposure in young children are thus important to understand. OBJECTIVE: To examine if a single anesthesia exposure in otherwise healthy young children was associated with impaired neurocognitive development and abnormal behavior in later childhood...
June 7, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27022143/nf%C3%AE%C2%BAb1-is-essential-to-prevent-the-development-of-multiorgan-autoimmunity-by-limiting-il-6-production-in-follicular-b-cells
#11
Elisha de Valle, George Grigoriadis, Lorraine A O'Reilly, Simon N Willis, Mhairi J Maxwell, Lynn M Corcoran, Evelyn Tsantikos, Jasper K S Cornish, Kirsten A Fairfax, Ajithkumar Vasanthakumar, Mark A Febbraio, Margaret L Hibbs, Marc Pellegrini, Ashish Banerjee, Philip D Hodgkin, Axel Kallies, Fabienne Mackay, Andreas Strasser, Steve Gerondakis, Raffi Gugasyan
We examined the role of NFκB1 in the homeostasis and function of peripheral follicular (Fo) B cells. Aging mice lacking NFκB1 (Nfκb1(-/-)) develop lymphoproliferative and multiorgan autoimmune disease attributed in large part to the deregulated activity of Nfκb1(-/-)Fo B cells that produce excessive levels of the proinflammatory cytokine interleukin 6 (IL-6). Despite enhanced germinal center (GC) B cell differentiation, the formation of GC structures was severely disrupted in the Nfκb1(-/-)mice. Bone marrow chimeric mice revealed that the Fo B cell-intrinsic loss of NFκB1 led to the spontaneous generation of GC B cells...
April 4, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27009035/rapid-recovery-pathway-after-spinal-fusion-for-idiopathic-scoliosis
#12
Wallis T Muhly, Wudbhav N Sankar, Kelly Ryan, Annette Norton, Lynne G Maxwell, Theresa DiMaggio, Sharon Farrell, Rachel Hughes, Alex Gornitzky, Ron Keren, John J McCloskey, John M Flynn
BACKGROUND: Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) is associated with significant pain and prolonged hospitalization. There is evidence that early mobilization and multimodal analgesia can accelerate functional recovery and reduced length of stay (LOS). Using these principles, we implemented a quality improvement initiative to enable earlier functional recovery in our AIS-PSF population. METHODS: We designed and implemented a standardized rapid recovery pathway (RRP) with evidence-based management recommendations for children aged 10 to 21 years undergoing PSF for AIS...
April 2016: Pediatrics
https://www.readbyqxmd.com/read/26826748/uncorrected-hyperopia-and-preschool-early-literacy-results-of-the-vision-in-preschoolers-hyperopia-in-preschoolers-vip-hip-study
#13
MULTICENTER STUDY
Marjean Taylor Kulp, Elise Ciner, Maureen Maguire, Bruce Moore, Jill Pentimonti, Maxwell Pistilli, Lynn Cyert, T Rowan Candy, Graham Quinn, Gui-Shuang Ying
PURPOSE: To compare early literacy of 4- and 5-year-old uncorrected hyperopic children with that of emmetropic children. DESIGN: Cross-sectional. PARTICIPANTS: Children attending preschool or kindergarten who had not previously worn refractive correction. METHODS: Cycloplegic refraction was used to identify hyperopia (≥3.0 to ≤6.0 diopters [D] in most hyperopic meridian of at least 1 eye, astigmatism ≤1.5 D, anisometropia ≤1...
April 2016: Ophthalmology
https://www.readbyqxmd.com/read/26690879/functional-and-genomic-insights-into-the-pathogenesis-of-burkholderia-species-to-rice
#14
REVIEW
Lynn M Naughton, Shi-qi An, Ingyu Hwang, Shan-Ho Chou, Yong-Qiang He, Ji-Liang Tang, Robert P Ryan, J Maxwell Dow
A number of species of bacteria from the genus Burkholderia have been shown to be causal agents of diseases of rice. These diseases, caused by Burkholderia glumae, B. gladioli and B. plantarii, are becoming increasingly common across the globe. This is particularly so for B. glumae, whose ability to grow at elevated temperatures suggests that it may become a prevalent problem in an era of global warming. Despite the increasing threat to rice, relatively little is known about the virulence mechanisms employed by these pathogens...
March 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/26559907/neurotoxicity-general-anesthesia-in-young-children-and-a-survey-of-current-pediatric-anesthesia-practice-at-us-teaching-institutions
#15
Christopher G Ward, Scott J Hines, Lynne G Maxwell, Francis X McGowan, Lena S Sun
BACKGROUND: Recent articles in both scholarly journals and the lay press about the topic of anesthetic related neurotoxicity have increased the awareness and discussion of this topic with parents and other pediatric medical specialties (i.e., surgeons, radiologists, and pediatricians). AIM: The purpose of the present study was to survey how a subset of pediatric anesthesia departments in the US have responded to the issue of anesthetic related neurotoxicity in terms of clinical practice, training and communication with other medical specialties, and the frequency and timing of discussions with families...
January 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/26306545/a-retrospective-comparison-of-ropivacaine-and-2-chloroprocaine-continuous-thoracic-epidural-analgesia-for-management-of-postthoracotomy-pain-in-infants
#16
COMPARATIVE STUDY
Wallis T Muhly, Harshad G Gurnaney, Francis W Kraemer, Arjunan Ganesh, Lynne G Maxwell
INTRODUCTION: Continuous thoracic epidural analgesia is useful in the management of infants following thoracotomy. Concerns about drug accumulation and toxicity limit the amount of amide local anesthetics that can be delivered. Continuous epidural infusions of the ester local anesthetic chloroprocaine result in little drug accumulation allowing for higher infusion rates. We retrospectively compared patients managed with 1.5% 2- chloroprocaine or 0.1% ropivacaine epidural infusions to determine if the increased infusion rate resulted in similar or improved analgesia...
November 2015: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/25938108/learning-anatomy-can-dissection-and-peer-mediated-teaching-offer-added-benefits-over-prosection-alone
#17
Lynn Ashdown, Evan Lewis, Maxwell Hincke, Alireza Jalali
Purpose. To evaluate the impact of an optional thoracic dissection elective upon anatomy subject acquisition and determine whether peer-mediated teaching has a beneficial effect. Methodology. First year medical students' results on thoracic anatomy laboratory examinations over a five-year period were obtained. All students were taught in the laboratory using prosected specimens as part of a standard curriculum. A subset of students from each class volunteered to participate in an optional thoracic dissection...
2013: ISRN Anatomy
https://www.readbyqxmd.com/read/25833029/co-occurrence-of-alcohol-drug-use-dsm-5-alcohol-use-disorder-and-symptoms-of-drug-use-disorder-on-both-sides-of-the-u-s-mexico-border
#18
Guilherme Borges, Sarah Zemore, Ricardo Orozco, Cheryl J Cherpitel, Yu Ye, Jason Bond, Jane Carlisle Maxwell, Lynn Wallisch
BACKGROUND: The U.S.-Mexico border displays elevated rates of hazardous alcohol and drug use. Whether the co-occurrence of alcohol and drug use and disorders is also high in the border area is unknown. METHODS: Data are from the U.S.-Mexico Study on Alcohol and Related Conditions, a cross-sectional survey of randomly selected respondents interviewed from 2011 to 2013. Participants included 1,690 Mexican Americans from Texas (572 in an off-border city and 1,118 from 3 border cities) and 1,293 Mexicans from Nuevo Leon and Tamaulipas (415 in an off-border city and 878 from 3 Mexican cities bordering Texas) who reported drinking in the last 12 months...
April 2015: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/25615744/journal-club-molecular-breast-imaging-at-reduced-radiation-dose-for-supplemental-screening-in-mammographically-dense-breasts
#19
Deborah J Rhodes, Carrie B Hruska, Amy Lynn Conners, Cindy L Tortorelli, Robert W Maxwell, Katie N Jones, Alicia Y Toledano, Michael K O'Connor
OBJECTIVE. The purpose of this study was to assess the diagnostic performance of supplemental screening molecular breast imaging (MBI) in women with mammographically dense breasts after system modifications to permit radiation dose reduction. SUBJECTS AND METHODS. A total of 1651 asymptomatic women with mammographically dense breasts on prior mammography underwent screening mammography and adjunct MBI performed with 300-MBq (99m)Tc-sestamibi and a direct-conversion (cadmium zinc telluride) gamma camera, both interpreted independently...
February 2015: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/25603875/pain-care-for-patients-with-epidermolysis-bullosa-best-care-practice-guidelines
#20
Kenneth R Goldschneider, Julie Good, Emily Harrop, Christina Liossi, Anne Lynch-Jordan, Anna E Martinez, Lynne G Maxwell, Danette Stanko-Lopp
BACKGROUND: Inherited epidermolysis bullosa (EB) comprises a group of rare disorders that have multi-system effects and patients present with a number of both acute and chronic pain care needs. Effects on quality of life are substantial. Pain and itching are burdensome daily problems. Experience with, and knowledge of, the best pain and itch care for these patients is minimal. Evidence-based best care practice guidelines are needed to establish a base of knowledge and practice for practitioners of many disciplines to improve the quality of life for both adult and pediatric patients with EB...
October 9, 2014: BMC Medicine
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