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https://www.readbyqxmd.com/read/28340349/structure-reveals-mechanisms-of-viral-suppressors-that-intercept-a-crispr-rna-guided-surveillance-complex
#1
Saikat Chowdhury, Joshua Carter, MaryClare F Rollins, Sarah M Golden, Ryan N Jackson, Connor Hoffmann, Lyn'Al Nosaka, Joseph Bondy-Denomy, Karen L Maxwell, Alan R Davidson, Elizabeth R Fischer, Gabriel C Lander, Blake Wiedenheft
Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolved diverse anti-CRISPR (Acr) proteins that subvert these immune systems. The adaptive immune system in Pseudomonas aeruginosa (type I-F) relies on a 350 kDa CRISPR RNA (crRNA)-guided surveillance complex (Csy complex) to bind foreign DNA and recruit a trans-acting nuclease for target degradation. Here, we report the cryo-electron microscopy (cryo-EM) structure of the Csy complex bound to two different Acr proteins, AcrF1 and AcrF2, at an average resolution of 3...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28339439/dezocine-antagonizes-morphine-analgesia-upon-simultaneous-administration-in-rodent-models-of-acute-nociception
#2
Na-Na Li, Ya-Qin Huang, Ling-Er Huang, Shao-Hui Guo, Maxwell R Shen, Chen-Ling Guo, Sheng-Mei Zhu, Yong-Xing Yao
BACKGROUND: Dezocine is a powerful analgesic that can be less addictive than morphine, yet how the two drugs interact in vivo is poorly understood. Here we administered dezocine alone or in combination with morphine to different acute nociception paradigms to explore the interactions of the 2 drugs upon co-administration. OBJECTIVE: To evaluate how dezocine interacts with morphine in different acute nociception paradigms. STUDY DESIGN: Laboratory animal study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28337974/theory-of-electrical-conductivity-and-dielectric-permittivity-of-highly-aligned-graphene-based-nanocomposites
#3
Xiaodong Xia, Jia Hao, Yang Wang, Zheng Zhong, George J Weng
Highly aligned graphene-based nanocomposites are of great interest due to their excellent electrical properties along the aligned direction. Graphene fillers in these composites are not necessarily perfectly aligned, but their orientations are highly confined to a certain angle, with 90-degree giving rise to the randomly oriented state and 0-degree to the perfectly aligned one. Recent experiments have shown that electrical conductivity and dielectric permittivity of highly aligned graphene-polymer nanocomposites are strongly dependent on this distribution angle, but at present no theory seems to exist to address this issue...
March 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28337936/females-exposed-to-24%C3%A2-h-of-sleep-deprivation-do-not-experience-greater-physiological-strain-but-do-perceive-heat-illness-symptoms-more-severely-during-exercise-heat-stress
#4
Rebecca Relf, Ashley Willmott, Jessica Mee, Oliver Gibson, Arron Saunders, Mark Hayes, Neil Maxwell
There is limited and inconclusive evidence surrounding the physiological and perceptual responses to heat stress while sleep deprived, especially for females. This study aimed to quantify the effect of 24 h sleep deprivation on physiological strain and perceptual markers of heat-related illness in females. Nine females completed two 30-min heat stress tests (HST) separated by 48 h in 39°C, 41% relative humidity at a metabolic heat production of 10 W · kg(-1). The non-sleep deprived HST was followed by the sleep deprivation (SDHST) trial for all participants during the follicular phase of the menstrual cycle...
March 24, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28337818/exploration-of-information-and-support-needs-in-relation-to-health-concerns-diet-and-physical-activity-in-colorectal-cancer-survivors
#5
S J Hardcastle, C Maxwell-Smith, M S Hagger, M O'Connor, C Platell
The purpose of the current study was to explore colorectal cancer survivors' information and support needs in relation to health concerns and health behaviour change. Face-to-face interviews were conducted with participants who had completed active treatment for cancer within the previous 2 years. Participants were colorectal cancer survivors (N = 24, men = 11, women = 13 M, age = 69.38 years, SD = 4.19) recruited from a hospital in Perth, Australia on the basis that they had existing morbidities that put them at increased risk of cardiovascular disease...
March 24, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28336561/mice-lacking-the-inhibitory-collagen-receptor-lair-1-exhibit-a-mild-thrombocytosis-and-hyperactive-platelets
#6
Christopher W Smith, Steven G Thomas, Zaher Raslan, Pushpa Patel, Maxwell Byrne, Marie Lordkipanidzé, Danai Bem, Linde Meyaard, Yotis A Senis, Steve P Watson, Alexandra Mazharian
OBJECTIVE: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a collagen receptor that belongs to the inhibitory immunoreceptor tyrosine-based inhibition motif-containing receptor family. It is an inhibitor of signaling via the immunoreceptor tyrosine-based activation motif-containing collagen receptor complex, glycoprotein VI-FcRγ-chain. It is expressed on hematopoietic cells, including immature megakaryocytes, but is not detectable on platelets. Although the inhibitory function of LAIR-1 has been described in leukocytes, its physiological role in megakaryocytes and in particular in platelet formation has not been explored...
March 23, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28336156/pediatric-arterial-ischemic-stroke-epidemiology-risk-factors-and-management
#7
Ryan J Felling, Lisa R Sun, Emily C Maxwell, Neil Goldenberg, Timothy Bernard
Pediatric arterial ischemic stroke (AIS) is an uncommon but important cause of neurologic morbidity in neonates and children, with consequences including hemiparesis, intellectual disabilities, and epilepsy. The causes of pediatric AIS are unique to those typically associated with stroke in adults. Familiarity with the risk factors for AIS in children will help with efficient diagnosis, which is unfortunately frequently delayed. Here we review the epidemiology and risk factors for AIS in neonates and children...
March 7, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28334036/multidrug-resistant-tuberculosis-in-prisons-located-in-former-soviet-countries-a-systematic-review
#8
Maxwell Droznin, Allen Johnson, Asal Mohamadi Johnson
BACKGROUND: A systematic literature review was performed to investigate the occurrence of multidrug-resistant tuberculosis (MDR TB) in prisons located in countries formerly part of the Soviet Union. METHODS: A systematic search of published studies reporting MDR TB occurrence in prisons located in former Soviet countries was conducted by probing PubMed and Cumulative Index Nursing and Allied Health Literature for articles that met predetermined inclusion criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28334007/a-functional-variant-in-neph3-gene-confers-high-risk-of-renal-failure-in-primary-hematuric-glomerulopathies-evidence-for-predisposition-to-microalbuminuria-in-the-general-population
#9
Konstantinos Voskarides, Charalambos Stefanou, Myrtani Pieri, Panayiota Demosthenous, Kyriakos Felekkis, Maria Arsali, Yiannis Athanasiou, Dimitris Xydakis, Kostas Stylianou, Eugenios Daphnis, Giorgos Goulielmos, Petros Loizou, Judith Savige, Martin Höhne, Linus A Völker, Thomas Benzing, Patrick H Maxwell, Daniel P Gale, Mathias Gorski, Carsten Böger, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Michalis Zavros, Alkis Pierides, Constantinos Deltas
BACKGROUND: Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a possible development for a subset of patients on long-term follow-up, through the onset of focal and segmental glomerulosclerosis (FSGS). We hypothesize that genetic modifiers may explain this variability of symptoms. METHODS: We looked in silico for potentially deleterious functional SNPs, using very strict criteria, in all the genes significantly expressed in the slit diaphragm (SD)...
2017: PloS One
https://www.readbyqxmd.com/read/28333986/building-the-road-to-a-regional-zoonoses-strategy-a-survey-of-zoonoses-programmes-in-the-americas
#10
Melody J Maxwell, Mary H Freire de Carvalho, Armando E Hoet, Marco A N Vigilato, Julio C Pompei, Ottorino Cosivi, Victor J Del Rio Vilas
BACKGROUND: In recent years, global public health security has been threatened by zoonotic disease emergence as exemplified by outbreaks of H5N1 and H1N1 influenza, SARS, and most recently Ebola and Zika. Additionally, endemic zoonoses, such as rabies, burden countries year after year, placing demands on limited finances and personnel. To survey the baseline status of the emerging and endemic zoonoses programmes of the Latin American and the Caribbean (LAC) countries, the Pan American Health Organization (PAHO) conducted a survey of priority emerging and endemic zoonoses, countries´ prioritization criteria and methodologies, and suggestions to strengthen countries capacities and regional approaches to zoonoses control...
2017: PloS One
https://www.readbyqxmd.com/read/28333267/commentary-on-aesthetic-breast-surgery-and-concomitant-procedures-incidence-and-risk-factors-for-major-complications-in-73-608-cases
#11
Allen Gabriel, G Patrick Maxwell
No abstract text is available yet for this article.
March 3, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28332585/topology-optimisation-of-wideband-coaxial-to-waveguide-transitions
#12
Emadeldeen Hassan, Daniel Noreland, Eddie Wadbro, Martin Berggren
To maximize the matching between a coaxial cable and rectangular waveguides, we present a computational topology optimisation approach that decides for each point in a given domain whether to hold a good conductor or a good dielectric. The conductivity is determined by a gradient-based optimisation method that relies on finite-difference time-domain solutions to the 3D Maxwell's equations. Unlike previously reported results in the literature for this kind of problems, our design algorithm can efficiently handle tens of thousands of design variables that can allow novel conceptual waveguide designs...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331634/multi-modal-imaging-and-anatomic-classification-of-the-white-dot-syndromes
#13
REVIEW
Meisha L Raven, Alexander L Ringeisen, Yoshihiro Yonekawa, Maxwell S Stem, Lisa J Faia, Justin L Gottlieb
The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. The categories include local uveitic syndromes with choroidal pathology, systemic uveitic syndromes with choroidal pathology, and multifocal choroiditis with outer retinal/choriocapillaris pathology with uveitis and without uveitis...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28330245/co-metabolism-of-thiocyanate-and-free-cyanide-by-exiguobacterium-acetylicum-and-bacillus-marisflavi-under-alkaline-conditions
#14
Lukhanyo Mekuto, Oluwadara Oluwaseun Alegbeleye, Seteno Karabo Obed Ntwampe, Maxwell Mewa Ngongang, John Baptist Mudumbi, Enoch A Akinpelu
The continuous discharge of cyanide-containing effluents to the environment has necessitated for the development of environmentally benign treatment processes that would result in complete detoxification of the cyanide-containing wastewaters, without producing additional environmental toxicants. Since biological detoxification of hazardous chemical compounds has been renowned for its robustness and environmental-friendliness, the ability of the Exiguobacterium acetylicum (GenBank accession number KT282229) and Bacillus marisflavi (GenBank accession number KR016603) to co-metabolise thiocyanate (SCN(-)) and free cyanide (CN(-)) under alkaline conditions was evaluated...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329517/purple-patches-in-an-immunocompromised-patient-a-report-of-secondary-disseminated-cutaneous-mucormycosis-in-a-man-with-chronic-lymphocytic-leukemia
#15
Sanjana Iyengar, Cindy J Chambers, Jillian W Millsop, Maxwell A Fung, Victoria R Sharon
A 60-year-old man with chronic lymphocytic leukemiadeveloped a deeply violaceous annular patchwith a halo of erythema on the right thigh duringhospitalization for neutropenic fever. Associatedsymptoms included chronic cough and fatigue.Bilateral lung opacities with hilar lymphadenopathywere noted on chest computed tomographyscan. Punch biopsy and tissue culture confirmeda diagnosis of secondary disseminated cutaneousmucormycosis. Although rare, physicians shouldinclude mucormycosis in the differential diagnosisof purpuric patches in immunosuppressed patients...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329051/caloric-restriction-mimetics-slow-aging-of-neuromuscular-synapses-and-muscle-fibers
#16
Jessica Stockinger, Nicholas Maxwell, Dillon Shapiro, Rafael deCabo, Gregorio Valdez
Resveratrol and metformin have been shown to mimic some aspects of caloric restriction and exercise. However, it remains unknown if these molecules also slow age-related synaptic degeneration, as previously shown for caloric restriction and exercise. In this study, we examined the structural integrity of neuromuscular junctions (NMJs) in 2-year-old mice treated with resveratrol and metformin starting at 1 year of age. We found that resveratrol significantly slows aging of NMJs in the extensor digitorum longus muscle of 2-year-old mice...
March 7, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328616/borderline-tuberculoid-leprosy-masquerading-as-granuloma-annulare-a-clinical-and-histological-pitfall
#17
Tian Hao Zhu, Faranak Kamangar, Marc Silverstein, Maxwell A Fung
INTRODUCTION: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae, an intracellular acid-fast bacillus that tends to infect the skin and peripheral nerves. Because of the wide array of cutaneous manifestation, diagnosis is not always straightforward, especially in nonendemic regions of the world such as the United States. CASE REPORT: The authors report an unusual case of borderline tuberculoid leprosy in an 80-year-old white woman from California...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28325183/antiherpetic-drugs-in-equine-medicine
#18
REVIEW
Lara K Maxwell
Since vaccination may not prevent disease, antiherpetic drugs have been investigated for the therapy of several equine herpesviruses. Drug efficacy has been assessed in horses with disease, but most evidence is in vitro, in other species, or empirical. Oral valacyclovir is most often administered in the therapy of equine herpesvirus type-1 (EHV-1) to protect adult horses from equine herpesvirus myeloencephalopathy, while oral acyclovir is frequently administered for EHV-5 infection in the therapy of equine multinodular pulmonary fibrosis...
April 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28323471/estimating-the-proportion-of-childhood-cancer-cases-and-costs-attributable-to-the-environment-in-california
#19
Lauren Nelson, Jhaqueline Valle, Galatea King, Paul K Mills, Maxwell J Richardson, Eric M Roberts, Daniel Smith, Paul English
OBJECTIVES: To estimate the proportion of cases and costs of the most common cancers among children aged 0 to 14 years (leukemia, lymphoma, and brain or central nervous system tumors) that were attributable to preventable environmental pollution in California in 2013. METHODS: We conducted a literature review to identify preventable environmental hazards associated with childhood cancer. We combined risk estimates with California-specific exposure prevalence estimates to calculate hazard-specific environmental attributable fractions (EAFs)...
March 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28323458/clozapine-related-tachycardia-in-an-adolescent-with-treatment-resistant-early-onset-schizophrenia
#20
Venkata Kolli, Dalton Bourke, Jeannie Ngo, Maxwell J Luber, Barbara J Coffey
No abstract text is available yet for this article.
March 2017: Journal of Child and Adolescent Psychopharmacology
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