keyword
https://read.qxmd.com/read/38536980/connective-tissue-disease-associated-interstitial-lung-disease
#1
JOURNAL ARTICLE
Karin Mueller Storrer, Carolina de Souza Müller, Maxwell Cássio de Albuquerque Pessoa, Carlos Alberto de Castro Pereira
Connective tissue disease-associated interstitial lung disease (CTD-ILD) represents a group of systemic autoimmune disorders characterized by immune-mediated organ dysfunction. Systemic sclerosis, rheumatoid arthritis, idiopathic inflammatory myositis, and Sjögren's syndrome are the most common CTDs that present with pulmonary involvement, as well as with interstitial pneumonia with autoimmune features. The frequency of CTD-ILD varies according to the type of CTD, but the overall incidence is 15%, causing an important impact on morbidity and mortality...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536067/targeted-and-shallow-whole-genome-sequencing-identifies-therapeutic-opportunities-in-p53abn-endometrial-cancers
#2
JOURNAL ARTICLE
Amy Jamieson, Juliana Sobral de Barros, Dawn R Cochrane, J Maxwell Douglas, Sameer Shankar, Branden J Lynch, Samuel Leung, Spencer Martin, Janine Senz, Amy Lum, Yvette Drew, C Blake Gilks, David G Huntsman, Jessica N McAlpine
PURPOSE: Shallow whole genome sequencing (sWGS) can detect copy number (CN) aberrations. In high-grade serous ovarian (HGSOC) sWGS identified CN signatures such as homologous recombination deficiency (HRD) to direct therapy. We applied sWGS with targeted sequencing to p53abn endometrial cancers (ECs) to identify additional prognostic stratification and therapeutic opportunities. EXPERIMENTAL DESIGN: sWGS and targeted panel sequencing was performed on formalin-fixed paraffin-embedded p53abn ECs...
March 27, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38533909/use-of-nonhuman-sera-as-a-highly-cost-effective-internal-standard-for-quantitation-of-multiple-human-proteins-using-species-specific-tryptic-peptides-applicability-in-clinical-lc-ms-analyses
#3
JOURNAL ARTICLE
Geraldine Williams, Lewis Couchman, David R Taylor, Jatinderpal K Sandhu, Oliver C Slingsby, Leong L Ng, Cajetan F Moniz, Donald J L Jones, Colleen B Maxwell
Quantitation of proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is complex, with a multiplicity of options ranging from label-free techniques to chemically and metabolically labeling proteins. Increasingly, for clinically relevant analyses, stable isotope-labeled (SIL) internal standards (ISs) represent the "gold standard" for quantitation due to their similar physiochemical properties to the analyte, wide availability, and ability to multiplex to several peptides. However, the purchase of SIL-ISs is a resource-intensive step in terms of cost and time, particularly for screening putative biomarker panels of hundreds of proteins...
March 27, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38533696/code-of-ethics-and-professional-standards-of-conduct-for-emergency-management-professionals
#4
JOURNAL ARTICLE
Sandy Maxwell Smith, Shirley Feldmann-Jensen
The Code of Ethics and Professional Standards of Conduct for Emergency Management Professionals (2022) was recently created to further delineate the ethical boundaries and conduct expectations for professional emergency management practice. Significantly, the code of ethics provides an essential foundation toward recognition as a profession with hallmarks of monopoly, autonomy, and authority. The code and standards of conduct establish a clear definition of the role emergency management has in overseeing a complex, diverse risk portfolio that protects lives, livelihoods, and quality of life...
2024: Journal of Emergency Management: JEM
https://read.qxmd.com/read/38533184/flexible-bayesian-inference-on-partially-observed-epidemics
#5
JOURNAL ARTICLE
Maxwell H Wang, Jukka-Pekka Onnela
Individual-based models of contagious processes are useful for predicting epidemic trajectories and informing intervention strategies. In such models, the incorporation of contact network information can capture the non-randomness and heterogeneity of realistic contact dynamics. In this article, we consider Bayesian inference on the spreading parameters of an SIR contagion on a known, static network, where information regarding individual disease status is known only from a series of tests (positive or negative disease status)...
April 2024: Journal of Complex Networks
https://read.qxmd.com/read/38532736/prediction-of-internalizing-and-externalizing-symptoms-in-late-childhood-from-attention-deficit-hyperactivity-disorder-symptoms-in-early-childhood
#6
JOURNAL ARTICLE
Agnieszka Mlodnicka, Maxwell Mansolf, Aruna Chandran, Izzuddin M Aris, Catrina A Calub, Shaikh Ahmad, Allison Shapiro, David Cochran, Bibiana Restrepo, Rebecca Schmidt, Irva Hertz-Picciotto, Deborah Bennett, Diane R Gold, T Michael O'Shea, Leslie Leve, Julie B Schweitzer
Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data ( n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11...
March 27, 2024: Development and Psychopathology
https://read.qxmd.com/read/38532704/causes-of-intraoperative-neuromonitoring-events-in-adult-spine-deformity-surgery-a-systematic-review
#7
REVIEW
Chloe Cottone, David Kim, Christopher Lucasti, Maxwell M Scott, Benjamin C Graham, Nell Aronoff, Bilal Hasanspahic, David Kowalski, Justin Bird, Dil Patel
STUDY DESIGN: Systematic review. OBJECTIVES: Intraoperative neuromonitoring (IOMN) has become a standard practice in the detection and prevention of nerve damage and postoperative deficit. While multicenter studies have addressed this inquiry, there have been no systematic reviews to date. This systematic review identifies the leading causes of IONM alerts during adult spinal deformity (ASD) surgeries. METHODS: Following PRISMA guidelines, a literature search was performed in PubMed and Embase...
March 27, 2024: Global Spine Journal
https://read.qxmd.com/read/38531270/risk-of-post-tonsillectomy-hemorrhage-among-covid-19-positive-pediatric-patients
#8
JOURNAL ARTICLE
Ann M Martin, Zachary T Elliott, James A Leonard, Jessica H Maxwell, Kelly Scriven, Earl Harley
OBJECTIVE: COVID-19 infection has been demonstrated to increase risk for post-operative bleeding. This study investigated the impact of COVID-19 infection on post-tonsillectomy hemorrhage in pediatric patients, a potentially devastating complication. STUDY DESIGN: Retrospective cohort study. METHODS: The TriNetX database was queried for pediatric patients who underwent tonsillectomy and evaluated for outcomes of primary and secondary post-tonsillectomy hemorrhage...
February 8, 2024: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38528899/a-survey-of-undergraduate-medical-students-gender-awareness-and-bias-the-newfoundland-and-labrador-perspective
#9
JOURNAL ARTICLE
Erika Maxwell, Gillian Sheppard, Yanqing Yi
BACKGROUND: Female physicians and patients experience gender bias in healthcare. The purpose of this research is to explore medical students' gender bias toward physicians and patients and whether their bias varies by gender. METHODS: We surveyed medical students at Memorial University between November 2020 and April 2021. We recruited participants through Facebook, email, and e-posters. We collected demographic information, including gender and class year. We used the Nijmegen Gender Awareness in Medicine Scale to measure gender sensitivity, gender role ideology toward patients, and gender role ideology toward doctors...
February 2024: Canadian Medical Education Journal
https://read.qxmd.com/read/38525072/multi-wavelength-raman-microscopy-of-nickel-based-electron-transport-in-cable-bacteria
#10
JOURNAL ARTICLE
Bent Smets, Henricus T S Boschker, Maxwell T Wetherington, Gérald Lelong, Silvia Hidalgo-Martinez, Lubos Polerecky, Gert Nuyts, Karolien De Wael, Filip J R Meysman
Cable bacteria embed a network of conductive protein fibers in their cell envelope that efficiently guides electron transport over distances spanning up to several centimeters. This form of long-distance electron transport is unique in biology and is mediated by a metalloprotein with a sulfur-coordinated nickel (Ni) cofactor. However, the molecular structure of this cofactor remains presently unknown. Here, we applied multi-wavelength Raman microscopy to identify cell compounds linked to the unique cable bacterium physiology, combined with stable isotope labeling, and orientation-dependent and ultralow-frequency Raman microscopy to gain insight into the structure and organization of this novel Ni-cofactor...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38524797/a-new-flexible-regression-model-with-application-to-recovery-probability-covid-19-patients
#11
JOURNAL ARTICLE
F Prataviera, E M Hashimoto, E M M Ortega, G M Cordeiro, V G Cancho, R Vila
The aim of this study is to propose a generalized odd log-logistic Maxwell mixture model to analyze the effect of gender and age groups on lifetimes and on the recovery probabilities of Chinese individuals with COVID-19. We add new properties of the generalized Maxwell model. The coefficients of the regression and the recovered fraction are estimated by maximum likelihood and Bayesian methods. Further, some simulation studies are done to compare the regressions for different scenarios. Model-checking techniques based on the quantile residuals are addressed...
2024: Journal of Applied Statistics
https://read.qxmd.com/read/38524759/vaginal-calculus-formation-on-exposed-midurethral-sling-mesh
#12
Adam J Langer, Zenab Saeed, Elizabeth Barrett, Rose A Maxwell, David N Dhanraj, Geoffrey D Towers, Eyra A Agudu
The presence of a vaginal calculus is a rare clinical entity which may develop in the setting of vaginal urinary stagnation. Numerous factors contribute to stone formation, and management can be complicated by variations in size, location of the stone, and location of adjacent structures. Generally, once diagnosed, vaginal calculi should be removed and surrounding anatomy should be evaluated thoroughly for secondary fistula, erosion, or presence of an instituting foreign body. This report presents a case of vaginal calculus formation on exposed midurethral sling mesh in an elderly patient with hemorrhagic cystitis...
2024: Case Reports in Obstetrics and Gynecology
https://read.qxmd.com/read/38524266/effects-of-perioperative-clinical-hypnosis-on-heart-rate-variability-in-patients-undergoing-oncologic-surgery-secondary-outcomes-of-a-randomized-controlled-trial
#13
JOURNAL ARTICLE
Muhammad Abid Azam, Aliza Z Weinrib, P Maxwell Slepian, Brittany N Rosenbloom, Anna Waisman, Hance Clarke, Joel Katz
INTRODUCTION: Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome study, it was hypothesized that surgical oncology patients randomized to receive perioperative clinical hypnosis (CH) would demonstrate greater heart-rate variability (HRV) during rest and relaxation at a 1-month post-surgery assessment compared to a treatment-as-usual group (TAU)...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38523036/surgical-site-infections-at-prior-stoma-site-after-colostomy-closure-a-multi-institutional-analysis
#14
JOURNAL ARTICLE
Maxwell D Mirande, Nicholas P McKenna, Jack W Sample, Katherine A Bews, Justin T Brady, Dorin T Colibaseanu, Scott R Kelley
No abstract text is available yet for this article.
March 5, 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38521043/mixtures-of-per-and-polyfluoroalkyl-substances-pfas-alter-sperm-methylation-and-long-term-reprogramming-of-offspring-liver-and-fat-transcriptome
#15
JOURNAL ARTICLE
DruAnne L Maxwell, Oladele A Oluwayiose, Emily Houle, Katherine Roth, Karolina Nowak, Savni Sawant, Amanda L Paskavitz, Wanqing Liu, Katherine Gurdziel, Michael C Petriello, J Richard Pilsner
Male fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse male reproductive health. The mechanisms of these associations and their implications on offspring health remain unknown. The aims of the current study were to assess the effect of PFAS mixtures on the sperm methylome and transcriptional changes in offspring metabolic tissues (i...
March 16, 2024: Environment International
https://read.qxmd.com/read/38519798/the-e%C3%AE-ret-mouse-is-a-novel-model-of-hyperdiploid-b-cell-acute-lymphoblastic-leukemia
#16
JOURNAL ARTICLE
Ali Farrokhi, Tanmaya Atre, Jenna Rever, Mario Fidanza, Wendy Duey, Samuel Salitra, Junia Myung, Meiyun Guo, Sumin Jo, Anuli Uzozie, Fatemeh Baharvand, Nina Rolf, Franziska Auer, Julia Hauer, Stephan A Grupp, Patrice Eydoux, Philipp F Lange, Alix E Seif, Christopher A Maxwell, Gregor S D Reid
The presence of supernumerary chromosomes is the only abnormality shared by all patients diagnosed with high-hyperdiploid B cell acute lymphoblastic leukemia (HD-ALL). Despite being the most frequently diagnosed pediatric leukemia, the lack of clonal molecular lesions and complete absence of appropriate experimental models have impeded the elucidation of HD-ALL leukemogenesis. Here, we report that for 23 leukemia samples isolated from moribund Eμ-Ret mice, all were characterized by non-random chromosomal gains, involving combinations of trisomy 9, 12, 14, 15, and 17...
March 22, 2024: Leukemia
https://read.qxmd.com/read/38518912/a-comprehensive-review-of-recent-advances-in-the-applications-and-biosynthesis-of-oxalic-acid-from-bio-derived-substrates
#17
REVIEW
Andrew Nosakhare Amenaghawon, Joshua Efosa Ayere, Ubani Oluwaseun Amune, Ifechukwude Christopher Otuya, Emmanuel Christopher Abuga, Chinedu Lewis Anyalewechi, Oseweuba Valentine Okoro, Jude A Okolie, Peter Kayode Oyefolu, Steve Oshiokhai Eshiemogie, Blessing Esohe Osahon, Melissa Omede, Stanley Aimhanesi Eshiemogie, Shedrach Igemhokhai, Maxwell Ogaga Okedi, Heri Septya Kusuma, Obiora Ebuka Muojama, Amin Shavandi, Handoko Darmokoesoemo
Organic acids are important compounds with numerous applications in different industries. This work presents a comprehensive review of the biological synthesis of oxalic acid, an important organic acid with many industrial applications. Due to its important applications in pharmaceuticals, textiles, metal recovery, and chemical and metallurgical industries, the global demand for oxalic acid has increased. As a result, there is an increasing need to develop more environmentally friendly and economically attractive alternatives to chemical synthesis methods, which has led to an increased focus on microbial fermentation processes...
March 20, 2024: Environmental Research
https://read.qxmd.com/read/38518377/cavitation-induced-pressure-saturation-a-mechanism-governing-bubble-nucleation-density-in-histotripsy
#18
JOURNAL ARTICLE
Adam Maxwell, Eli Vlaisavljevich

Histotripsy is a noninvasive focused ultrasound therapy that mechanically disintegrates tissue by acoustic cavitation clouds. In this study, we investigate a mechanism limiting the density of bubbles that can nucleate during a histotripsy pulse. In this mechanism, the pressure generated by the initial bubble expansion effectively negates the incident pressure in the vicinity of the bubble. From this effect, the immediately adjacent tissue is prevented from experiencing the transient tension to nucleate bubbles...
March 22, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38517458/conceptualizing-sexual-wellbeing-a-qualitative-investigation-to-inform-development-of-a-measure-natsal-sw
#19
JOURNAL ARTICLE
R Lewis, R Bosó Pérez, K J Maxwell, D Reid, W Macdowall, C Bonell, J D Fortenberry, C H Mercer, P Sonnenberg, K R Mitchell
Despite increasing scientific and policy interest in sexual wellbeing, it remains poorly conceptualized. Many studies purporting to measure it instead measure related but distinct concepts, such as sexual satisfaction. This lack of conceptual clarity impedes understanding, measuring, and improving sexual wellbeing. We present qualitative research from multi-stage, mixed-methods work to develop a new measure of sexual wellbeing (Natsal-SW) for the fourth British National Survey of Sexual Attitudes & Lifestyles...
March 22, 2024: Journal of Sex Research
https://read.qxmd.com/read/38517075/recovery-after-sport-related-concussion-in-collegiate-athletes-with-self-reported-pre-injury-migraines
#20
JOURNAL ARTICLE
Douglas P Terry, Jacob Jo, Kristen Williams, Bruce A Maxwell, Paul Berkner, Grant L Iverson, Scott L Zuckerman
Pre-injury migraines might be a risk factor for prolonged recovery after sport-related concussion (SRC). We sought to examine whether a pre-injury history of migraines is associated with worse recovery following SRC in collegiate athletes. Data were collected through a prospective concussion surveillance system in 11 NCAA Division III college athletic programs between 09/2014-03/2020. Our primary independent variable, pre-injury migraines, were self-reported by the athletes. Between those with and without migraines, the outcomes of days to return-to-learn (RTL) without academic accommodations and return-to-play (RTP) and were compared using Mann-Whitney U tests...
March 22, 2024: Journal of Neurotrauma
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