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Jeff Richardson, Angelo Iezzi, Gang Chen, Aimee Maxwell
INTRODUCTION: This paper suggests and tests a reason why the public might support the funding of services for rare diseases (SRDs) when the services are effective but not cost effective, i.e. when more health could be produced by allocating funds to other services. It is postulated that the fairness of funding a service is influenced by a comparison of the average patient benefit with the average cost to those who share the cost. METHODS: Survey respondents were asked to allocate a budget between cost-effective services that had a small effect upon a large number of relatively well patients and SRDs that benefited a small number of severely ill patients but were not cost effective because of their high cost...
March 2017: PharmacoEconomics Open
Maxwell W Terban, Debasis Banerjee, Sanjit Ghose, Bharat Medasani, Anil Shukla, Benjamin A Legg, Yufan Zhou, Zihua Zhu, Maria L Sushko, James J De Yoreo, Jun Liu, Praveen K Thallapally, Simon J L Billinge
Given the wide-ranging potential applications of metal organic frameworks (MOFs), an emerging imperative is to understand their formation with atomic scale precision. This will aid in designing syntheses for next-generation MOFs with enhanced properties and functionalities. Major challenges are to characterize the early-stage seeds, and the pathways to framework growth, which require synthesis coupled with in situ structural characterization sensitive to nanoscale structures in solution. Here we report measurements of an in situ synthesis of a prototypical MOF, ZIF-8, utilizing synchrotron X-ray atomic pair distribution function (PDF) analysis optimized for sensitivity to dilute species, complemented by mass spectrometry, electron microscopy, and density functional theory calculations...
February 14, 2018: Nanoscale
Cahit Kaya, Cheryl Hanley-Maxwell, Fong Chan, Timothy Tansey
BACKGROUND: It is important to investigate receipt of vocational rehabilitation (VR) services, service patterns and outcomes for youth with autism, so that limited public resources can be used more efficiently. METHOD: This study used chi-squared automatic interaction detector, and multivariate logistic regression analysis to investigate relationships between demographic variables, receipt of VR services and employment outcomes for transition-age youth (TAY) with Autism...
February 14, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
William D Pearse, Ignacio Morales-Castilla, Logan S James, Maxwell Farrell, Frédéric Boivin, T Jonathan Davies
Studying the macroevolution of the songs of Passeriformes (perching birds) has proved challenging. The complexity of the task stems not just from the macroevolutionary and macroecological challenge of modelling so many species, but also from the difficulty in collecting and quantifying birdsong itself. Using machine learning techniques, we extracted songs from a large citizen science dataset, and then analysed the evolution, and biotic and abiotic predictors of variation in birdsong across 578 passerine species...
February 14, 2018: Evolution; International Journal of Organic Evolution
Naveed Malek, Maxwell Damian
We discuss the assessment and differential diagnoses of a middle-aged man who presented with trismus, double vision and behavioural problems. MRI scan of the brain was initially normal, but a month later showed high signal in the hippocampal region on fluid attenuated inversion recovery sequence (FLAIR) imaging. We suspected a paraneoplastic brainstem encephalitis because of his smoking history, rapidly progressive symptoms and abnormal brainstem signs. A positron emission tomography-CT scan identified abnormal subcarinal nodes, shown on biopsy to be metastatic small cell lung cancer...
February 13, 2018: Practical Neurology
Joanne Reid, Helen R Noble, Gary Adamson, Andrew Davenport, Ken Farrington, Denis Fouque, Kamyar Kalantar-Zadeh, John Mallett, C McKeaveney, S Porter, David S Seres, Joanne Shields, Adrian Slee, Miles D Witham, Alexander P Maxwell
BACKGROUND: Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some evidence of muscle wasting. ESKD is associated with an increase in inflammatory cytokines and can result in cachexia, with the loss of muscle and fat stores. At present, only limited data are available on the classification of wasting experienced by persons with ESKD...
February 13, 2018: BMC Nephrology
Thressi Maxwell, Kyu Shik Lee, Soyoung Kim, Kyung-Soo Nam
Arctigenin, a member of the Asteraceae family, is a biologically active lignan that is consumed worldwide due to its several health benefits. However, its use may pose a problem for patients with estrogen receptor (ER)α-positive breast cancer, since studies have shown that arctigenin is a phytoestrogen that exerts a proliferative effect by binding to the ER. Thus, in this study, we examined the effect of arctigenin on ERα-positive MCF-7 human breast cancer cells to determine whether the consumption of arctigenin is safe for patients with breast cancer...
February 9, 2018: International Journal of Oncology
Theresa A Zwaschka, Justin S Ahn, Bryan W Cunitz, Michael R Bailey, Barbrina L Dunmire, Mathew D Sorensen, Jonathan D Harper, Adam D Maxwell
PURPOSE: Burst wave lithotripsy (BWL) is a new technology in development to fragment urinary stones. Ultrasonic propulsion is a separate technology under investigation for displacing stones. We measure the effect of propulsion pulses on stone fragmentation from BWL. MATERIAL/METHODS: Two artificial stone models (crystalline calcite, BegoStone plaster) and human calcium oxalate monohydrate stones measuring 5-8 mm were subjected to ultrasound exposures in a polyvinyl chloride tissue phantom within a water bath...
February 13, 2018: Journal of Endourology
Brayan F García, Soheil Saraji
HYPOTHESIS: The relaxation time in viscoelastic surfactant solutions is a function of temperature, salt/surfactant concentrations, resting conditions, as well as shear frequency. The simplistic assumption of a single and constant relaxation time is not representative of all relaxation modes in these solutions especially at high frequencies. EXPERIMENTS: Steady-state and oscillatory measurements are carried out to study the effects of high temperature, concentration and resting condition on the rheology of surfactants/salt mixtures including a non-ionic and a zwitterionic/anionic surfactant system...
February 1, 2018: Journal of Colloid and Interface Science
Courtney D Grassham, Sara Rady, Kimberly Foster, Karen S SantaCruz, John F Kuttesch, Jessie R Maxwell
Congenital brain tumors are rare, representing <2% of all childhood brain tumors. Of these, ependymoblastoma is a profoundly aggressive embryonal brain tumor that is included in the diagnostic entity known as an embryonal tumor with multilayered rosettes. This report of a congenital ependymoblastoma diagnosed at birth aims to highlight how much remains unknown about embryonal tumor with multilayered rosettes and the devastating prognosis of this condition. Despite recent advancements made in identifying molecular targets for therapy, this tumor continues to have a high rate of recurrence with few successful treatment options, especially when diagnosed in the newborn period...
February 9, 2018: Journal of Pediatric Hematology/oncology
Sudip Das, Rochish M Thaokar
The axisymmetric electrohydrodynamic deformation of an elastic capsule with a capacitive membrane obeying the Skalak law under a uniform AC electric field is investigated using analytical and boundary integral theory. The low capillary number (the ratio of destabilizing shear or electric force to the stabilizing elastic force) regime shows that time-averaged prolate and oblate spheroid deformations, and the time-periodic prolate-sphere, oblate-sphere breathing modes are commensurate with the time averaged-deformation...
February 12, 2018: Soft Matter
Sora Choi, Afua A Gyamfi, Prince Neequaye, Samuel Addo, Frank J Gonzalez, Maxwell A Gyamfi
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that defends against toxic agents. We have shown that PXR promotes chronic ethanol (EtOH)-induced steatosis. Therefore, we examined the role of PXR in binge EtOH-induced hepatotoxicity. Male wild type (WT) and Pxr-null mice were orally administered three binge doses of EtOH (4.5 g/kg, every 12 hours) and euthanized four hours after the final dose. Pxr-null mice displayed higher basal mRNA levels of hepatic lipogenic transcription factor sterol regulatory element binding protein 1c (Srebp-1c) and its target stearoyl-CoA desaturase 1 (Scd1) and the lipid peroxide detoxifying aldo-keto reductase 1b7 (Akr1b7) and higher protein levels of EtOH-metabolizing alcohol dehydrogenase 1 (ADH1)...
February 5, 2018: Journal of Pharmacology and Experimental Therapeutics
Yi-Ren Chen, Jon Sole, Beatrice Ugiliweneza, Eli Johnson, Eric Burton, Shiao Y Woo, Maria Koutourousiou, Brian Williams, Maxwell Boakye, Stephen Skirboll
BACKGROUND: Despite multimodal therapies extending patient survival, Glioblastoma (GBM) recurrence is all but a certainty. To date, there are few single-center studies looking at reoperations. Our study aimed to assess GBM reoperation trends nationally in elderly patients, with emphasis on outcomes. METHODS: The linked Surveillance, Epidemiology, and End Results (SEER) - Medicare database was searched to identify patients 66 years and older with GBM from 1997-2010...
February 7, 2018: World Neurosurgery
Benjamin Y Andrew, Anne D Cherry, Jennifer N Hauck, Alina Nicoara, Cory D Maxwell, Ryan M Konoske, Annemarie Thompson, Lakshmi D Kartha, Madhav Swaminathan, Mark Stafford-Smith
BACKGROUND: Acute kidney injury (AKI) is a common serious complication following cardiac surgery. Doppler-determined renal resistive index (RRI) is a promising early AKI biomarker in this population. However, the relationship between aortic valve pathology (insufficiency and/or stenosis) and RRI is unknown. This study aimed to investigate RRI variability related to aortic valve pathology. METHODS: In a retrospective review of cardiac surgery patients, RRI and aortic valve pathology were assessed prior to cardiopulmonary bypass using transesophageal echocardiography...
February 7, 2018: Annals of Thoracic Surgery
Emma C Hobbs, Kabemba E Mwape, Brecht Devleesschauwer, Sarah Gabriël, Mwelwa Chembensofu, Moses Mambwe, Isaac K Phiri, Maxwell Masuku, Gideon Zulu, Angela Colston, Arve Lee Willingham, Dirk Berkvens, Pierre Dorny, Emmanuel Bottieau, Niko Speybroeck
The tapeworm Taenia solium is endemic in Zambia, however its socioeconomic cost is unknown. During a large-scale interventional study conducted in Zambia, baseline economic costs of human and porcine T. solium infections were measured. Questionnaire surveys were conducted within three neighbourhoods in Zambia's Eastern province in 2015 and 2016. A human health questionnaire, capturing costs of clinical symptoms commonly attributable to human cysticercosis and taeniasis, was conducted in randomly selected households (n = 267)...
February 15, 2018: Veterinary Parasitology
Maxwell G Su, Brian P Schallenberg, Michael A Magee
No abstract text is available yet for this article.
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Robin E Bonomi, Maxwell Laws, Vadim Popov, Swatabdi Kamal, Shreya Potukutchi, Aleksandr Shavrin, Xin Lu, Nashaat Turkman, Ren-Shyan Liu, Thomas Mangner, Juri G Gelovani
PURPOSE: The purpose of this study was to develop a SIRT2-specific substrate-type radiotracer for non-invasive PET imaging of epigenetic regulatory processes mediated by SIRT2 in normal and disease tissues. PROCEDURES: A library of compounds containing tert-butyloxycarbonyl-lysine-aminomethylcoumarin backbone was derivatized with fluoroalkyl chains 3-16 carbons in length. SIRT2 most efficiently cleaved the myristoyl, followed by 12-fluorododecanoic and 10-fluorodecanoic groups (Kcat/Km 716...
February 8, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Matthew Reagor, Christopher B Osborn, Nikolas Tezak, Alexa Staley, Guenevere Prawiroatmodjo, Michael Scheer, Nasser Alidoust, Eyob A Sete, Nicolas Didier, Marcus P da Silva, Ezer Acala, Joel Angeles, Andrew Bestwick, Maxwell Block, Benjamin Bloom, Adam Bradley, Catvu Bui, Shane Caldwell, Lauren Capelluto, Rick Chilcott, Jeff Cordova, Genya Crossman, Michael Curtis, Saniya Deshpande, Tristan El Bouayadi, Daniel Girshovich, Sabrina Hong, Alex Hudson, Peter Karalekas, Kat Kuang, Michael Lenihan, Riccardo Manenti, Thomas Manning, Jayss Marshall, Yuvraj Mohan, William O'Brien, Johannes Otterbach, Alexander Papageorge, Jean-Philip Paquette, Michael Pelstring, Anthony Polloreno, Vijay Rawat, Colm A Ryan, Russ Renzas, Nick Rubin, Damon Russel, Michael Rust, Diego Scarabelli, Michael Selvanayagam, Rodney Sinclair, Robert Smith, Mark Suska, Ting-Wai To, Mehrnoosh Vahidpour, Nagesh Vodrahalli, Tyler Whyland, Kamal Yadav, William Zeng, Chad T Rigetti
We show that parametric coupling techniques can be used to generate selective entangling interactions for multi-qubit processors. By inducing coherent population exchange between adjacent qubits under frequency modulation, we implement a universal gate set for a linear array of four superconducting qubits. An average process fidelity of ℱ = 93% is estimated for three two-qubit gates via quantum process tomography. We establish the suitability of these techniques for computation by preparing a four-qubit maximally entangled state and comparing the estimated state fidelity with the expected performance of the individual entangling gates...
February 2018: Science Advances
Maxwell S Krieger, Jesse L Yedinak, Jane A Buxton, Mark Lysyshyn, Edward Bernstein, Josiah D Rich, Traci C Green, Scott E Hadland, Brandon D L Marshall
BACKGROUND: Synthetic opioid overdose mortality among young adults has risen more than 300% in the USA since 2013, primarily due to the contamination of heroin and other drugs with illicitly manufactured fentanyl. Rapid test strips, which can be used to detect the presence of fentanyl in drug samples (before use) or urine (after use), may help inform people about their exposure risk. The purpose of this study was to determine whether young adults who use drugs were willing to use rapid test strips as a harm reduction intervention to prevent overdose...
February 8, 2018: Harm Reduction Journal
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