Read by QxMD icon Read


Anna Forsyth, Rebecca McMillan, Doug Campbell, Gemma Malpas, Elizabeth Maxwell, Jamie Sleigh, Juergen Dukart, Joerg F Hipp, Suresh D Muthukumaraswamy
RATIONALE AND OBJECTIVES: The identification of biomarkers of drug action can be supported by non-invasive brain imaging techniques, such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), with simultaneous collection plausibly overcoming the limitations of either modality alone. Despite this, few studies have assessed the feasibility and utility of recording simultaneous EEG/fMRI in a drug study. METHODS: We used simultaneous EEG/fMRI to assess the modulation of neural activity by ketamine and midazolam, in a placebo-controlled, single-blind, three-way cross-over design...
November 14, 2018: Psychopharmacology
Maria Lourdes Chamorro, Maxwell V L Barclay
Background: The multimillion-dollar avocado industry is threatened by a number of serious insect pests, including at least seven species of Curculionidae. Of these, three Conotrachelus species are known to develop and feed on avocados: Conotrachelus aguacatae Barber, Conotrachelus perseae Barber and C. serpentinus (Klug); the first two are of economic importance. Recently, a series of unrecognised Conotrachelus was intercepted with avocado and other commodities by the USDA at various southern U...
2018: Biodiversity Data Journal
Colin S Maxwell
The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M systems. The model makes two main predictions. The first prediction is that the offspring of the first phage to gain a new methylation pattern by infecting a new host make up a disproportionate fraction of the subsequent specialist population, indicating that the plastically produced phenotype is highly predictive of evolutionary outcome...
November 13, 2018: MBio
Rebecca E W Kaplan, Colin S Maxwell, Nicole Kurhanewicz Codd, L Ryan Baugh
The C. elegans insulin-like signaling network supports homeostasis and developmental plasticity. The genome encodes 40 insulin-like peptides and one known receptor. Feedback regulation has been reported, but the extent of feedback and its effect on signaling dynamics in response to changes in nutrient availability has not been determined. We measured mRNA expression for each insulin-like peptide, the receptor daf-2 , components of the PI3K pathway, and its transcriptional effectors daf-16 /FoxO and skn-1 /Nrf at high temporal resolution during transition from a starved, quiescent state to a fed, growing state in wild type and mutants affecting daf-2 /InsR and daf-16 /FoxO...
November 13, 2018: Genetics
Tatiana Khokhlova, Pavel Rosnitskiy, Christopher Hunter, Adam Maxwell, Wayne Kreider, Gail Ter Haar, Marcia Costa, Oleg Sapozhnikov, Vera Khokhlova
Pulsed high intensity focused ultrasound was shown to enhance chemotherapeutic drug uptake in tumor tissue through inertial cavitation, which is commonly assumed to require peak rarefactional pressures to exceed a certain threshold. However, recent studies have indicated that inertial cavitation activity also correlates with the presence of shocks at the focus. The shock front amplitude and corresponding peak negative pressure ( p - ) in the focal waveform are primarily determined by the transducer F -number: less focused transducers produce shocks at lower p - ...
September 2018: Journal of the Acoustical Society of America
Yunmei Fang, Juntao Fei, Yuzheng Yang
This paper presents a novel algorithm for the design and analysis of an adaptive backstepping controller (ABC) for a microgyroscope. Firstly, Lagrange⁻Maxwell electromechanical equations are established to derive the dynamic model of a z -axis microgyroscope. Secondly, a nonlinear controller as a backstepping design approach is introduced and deployed in order to drive the trajectory tracking errors to converge to zero with asymptotic stability. Meanwhile, an adaptive estimator is developed and implemented with the backstepping controller to update the value of the parameter estimates in the Lyapunov framework in real-time...
July 3, 2018: Micromachines
Jian-Ping Yu, Hui-Lin Du, Xin Li
This paper presents an EMD (empirical mode decomposition)-based extraction approach to decouple the electric field fringe component impacts on the nonlinearity errors of a micro encoder-like capacitive displacement sensor. A calculated capacitance model built under Maxwell's equations against the impacts of electric field fringe component indicates that signals of this sensor are all in periodic co-sinusoidal waveforms. Applying the proposed EMD scheme, signals are decomposed into sets of intrinsic mode functions (IMFs) and a residual, in which a fundamental component represents all the features of sensor signal and reserves the local information...
May 1, 2018: Micromachines
Cuc H Tran, Maxwell Kligerman, Lesly L Andrecy, Melissa D Etheart, Paul Adrien, Jesse D Blanton, Max Millien, Ryan M Wallace
BACKGROUND: Approximately 59,000 people die from rabies worldwide annually. Haiti is one of the last remaining countries in the Western Hemisphere with endemic canine rabies. Canine-mediated rabies deaths are preventable with post-exposure prophylaxis (PEP): wound treatment, immunoglobulin, and vaccination. In countries where PEP is available, variability in healthcare seeking behaviors and lack of adherence to recommended treatment guidelines could also contribute to these deaths. Yet, few studies have addressed these issues...
November 13, 2018: PLoS Neglected Tropical Diseases
H V S Pessoni, P Banerjee, A Franco
Dielectric properties and impedance spectroscopic studies of single phase Zn1- xCoxO (0 ≤ x ≤ 0.05) ceramics, synthesized by a pressure-less solid state reaction method, have been carried out to investigate the origin of colossal dielectric permittivity (CP), ε' ∼ 105, in a wide frequency (2 × 101-2 × 106 Hz) range. These results show that a defect density within the grain is present in the materials due to the use of pressure-less sintering at high temperature for a long duration of time. The colossal dielectric response is essentially due to this electronic inhomogeneous conduction mechanism within the material due to the production of absorption current in the thin grain boundary region which accumulates charge at the interface and induces Maxwell-Wagner interfacial polarization...
November 9, 2018: Physical Chemistry Chemical Physics: PCCP
Fabian B Wadsworth, Taylor Witcher, Caron E J Vossen, Kai-Uwe Hess, Holly E Unwin, Bettina Scheu, Jonathan M Castro, Donald B Dingwell
Magma is a viscoelastic fluid that can support fracture propagation when local shear stresses are high, or relax and flow when shear stresses are low. Here we present experiments to confirm this using synthetic and natural magmatic liquids across eruptive conditions and use Maxwell's linear viscoelasticity to parameterize our results and predict the maximum stresses that can be supported during flow. This model proves universal across a large range of liquid compositions, temperatures, crystallinity and rates of strain relevant to shallow crustal magma ascent...
November 8, 2018: Nature Communications
Suryakant Niture, Maxwell A Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep, Deepak Kumar
BACKGROUND: Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis. Recent reports indicate that serotonin may promote tumor growth in liver cancer, however, the molecular mechanisms remain elusive. n this study, we investigated the role and molecular signaling mechanisms mediated by serotonin in liver cancer cell survival, drug resistance, and steatosis...
November 8, 2018: Cell Communication and Signaling: CCS
Jianning Shao, Bryan S Lee, Dominic Pelle, Maxwell Y Lee, Jason Savage, Joseph E Tanenbaum, Thomas E Mroz, Michael P Steinmetz
The use of intraoperative multimodal monitoring (IOM) in spinal deformity surgeries is well documented. In particular, pedicle subtraction osteotomy (PSO), a corrective procedure for sagittal deformity of the spine, often involves IOM usage. By providing immediate feedback to the operating surgeon, IOM has the potential to eliminate or at least minimize the risk of iatrogenic neurological injury. However, despite the widespread usage of IOM, there is currently no standardization of IOM usage in complex spine surgeries, including lumbar PSOs, and decisions concerning IOM utilization are often driven by surgeon experience and preference...
November 6, 2018: Clinical Spine Surgery
Paul A Devine, Aisling E Courtney, Alexander P Maxwell
Successful kidney transplantation offers patients with end-stage renal disease the greatest likelihood of survival. However, cardiovascular disease poses a major threat to both graft and patient survival in this cohort. Transplant recipients are unique in their accumulation of a wide range of traditional and non-traditional cardiovascular risk factors. Hypertension, diabetes, dyslipidaemia and obesity are highly prevalent in patients with end-stage renal disease. These risk factors persist following transplantation and are often exacerbated by the drugs used for immunosuppression in organ transplantation...
November 7, 2018: Journal of Nephrology
Ihn Kyung Jang, Abby Tyler, Chris Lyman, Maria Kahn, Michael Kalnoky, John C Rek, Emmanuel Arinaitwe, Harriet Adrama, Maxwell Murphy, Mallika Imwong, Clare L Ling, Stephane Proux, Warat Haohankhunnatham, Melissa Rist, Annette M Seilie, Amelia Hanron, Glenda Daza, Ming Chang, Smita Das, Rebecca Barney, Andrew Rashid, Jordi Landier, David S Boyle, Sean C Murphy, James S McCarthy, François Nosten, Bryan Greenhouse, Gonzalo J Domingo
INTRODUCTION: Malaria rapid diagnostic tests (RDTs) detect primarily Plasmodium (P.) falciparum antigen histidine-rich protein 2 (HRP2) and the malaria-conserved antigen lactate dehydrogenase (LDH) for P. vivax and other malaria species. The performance of RDTs and their utility is dependent on circulating antigen concentration distributions in infected individuals in a malaria endemic population and the limit-of-detection of the RDT for the antigens. A multiplexed immunoassay for the quantification of HRP2, P...
November 7, 2018: Journal of Clinical Microbiology
Xiaoyi Guo, Haitao Qi
The electro-osmotic peristaltic flow of a viscoelastic fluid through a cylindrical micro-channel is studied in this paper. The fractional Jeffreys constitutive model, including the relaxation time and retardation time, is utilized to describe the viscoelasticity of the fluid. Under the assumptions of long wavelength, low Reynolds number, and Debye-Hückel linearization, the analytical solutions of pressure gradient, stream function and axial velocity are explored in terms of Mittag-Leffler function by Laplace transform method...
November 23, 2017: Micromachines
Semin Joung, Jaewook Kim, Sehyun Kwak, Kyeo-Reh Park, S H Hahn, H S Han, H S Kim, J G Bak, S G Lee, Y-C Ghim
A Bayesian with Gaussian process-based numerical method to impute a few missing magnetic signals caused by impaired magnetic probes during tokamak operations is developed such that the real-time reconstruction of magnetic equilibria, whose performance strongly depends on the measured magnetic signals and their intactness, is affected minimally. Likelihood of the Bayesian model constructed with Maxwell's equations, specifically Gauss's law for magnetism and Ampère's law, results in an infinite number of solutions if two or more magnetic signals are missing...
October 2018: Review of Scientific Instruments
Jillian M Pattison, Sandra P Melo, Samantha N Piekos, Jessica L Torkelson, Elizaveta Bashkirova, Maxwell R Mumbach, Charlotte Rajasingh, Hanson Hui Zhen, Lingjie Li, Eric Liaw, Daniel Alber, Adam J Rubin, Gautam Shankar, Xiaomin Bao, Howard Y Chang, Paul A Khavari, Anthony E Oro
Human embryonic stem cell (hESC) differentiation promises advances in regenerative medicine1-3 , yet conversion of hESCs into transplantable cells or tissues remains poorly understood. Using our keratinocyte differentiation system, we employ a multi-dimensional genomics approach to interrogate the contributions of inductive morphogens retinoic acid and bone morphogenetic protein 4 (BMP4) and the epidermal master regulator p63 (encoded by TP63)4,5 during surface ectoderm commitment. In contrast to other master regulators6-9 , p63 effects major transcriptional changes only after morphogens alter chromatin accessibility, establishing an epigenetic landscape for p63 to modify...
November 5, 2018: Nature Genetics
Meng-Fu Maxwell Shih, Fred Pejman Davis, Gilbert Lee Henry, Josh Dubnau
The insect mushroom body (MB) is a conserved brain structure that plays key roles in a diverse array of behaviors. The Drosophila melanogaster MB is the primary invertebrate model of neural circuits related to memory formation and storage, and its development, morphology, wiring, and function has been extensively studied. MBs consist of intrinsic Kenyon Cells that are divided into three major neuron classes (γ, α'/β' and α/β) and 7 cell subtypes (γd, γm, α'/β'ap, α'/β'm, α/βp, α/βs and α/βc) based on their birth order, morphology, and connectivity...
November 5, 2018: G3: Genes—Genomes—Genetics
Maxwell T Hincke, Mylène Da Silva, Nicolas Guyot, Joël Gautron, Marc D McKee, Rodrigo Guabiraba-Brito, Sophie Réhault-Godbert
The integrated innate immune features of the calcareous egg and its contents are a critical underpinning of the remarkable evolutionary success of the Aves clade. Beginning at the time of laying, the initial protective structures of the egg, i.e., the biomineralized eggshell, egg-white antimicrobial peptides, and vitelline membrane, are rapidly and dramatically altered during embryonic development. The embryo-generated extra-embryonic tissues (chorioallantoic/amniotic membranes, yolk sac, and associated chambers) are all critical to counteract degradation of primary egg defenses during development...
November 2, 2018: Journal of Innate Immunity
Cathy A Maxwell, Mayur B Patel, Luis C Suarez-Rodriguez, Richard S Miller
Frailty is a predominant predictor of poor outcomes in older populations. This article presents a review of the concept of frailty and its role for prognostication among geriatric trauma and surgery patients. We discuss models of frailty defined in the scientific literature, emphasizing that frailty is a process of biologic aging. We emphasize the importance of screening, assessment, and inclusion of frailty indices for the development and use of prognostication instruments/tools in the population of interest...
February 2019: Clinics in Geriatric Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"