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https://www.readbyqxmd.com/read/28214638/pre-residency-publication-number-does-not-predict-academic-career-placement-in-neurosurgery
#1
Marcus Daniels, Tomas Garzon-Muvdi, Russell Maxwell, Rafael J Tamargo, Judy Huang, Tim Witham, Chetan Bettegowda, Kaisorn L Chaichana
OBJECTIVE: It is unclear if pre-residency and/or residency research work impacts academic neurosurgery placement post-residency. The goal of this study is to evaluate the impact that pre-residency and residency research publication has on attaining academic faculty positions. METHODS: Alumni information was collected from 65 of the 108 (60%) neurosurgery residency websites. Graduates from these programs between 2005-2015 (N=949) were analyzed to determine factors associated with an academic career...
February 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28213964/when-sensing-is-gambling-an-experimental-system-reveals-how-plasticity-can-generate-tunable-bet-hedging-strategies
#2
Colin S Maxwell, Paul M Magwene
Genotypes can persist in unpredictable environments by 'hedging their bets' and producing diverse phenotypes. Theoretical studies have shown that the phenotypic variability needed for a bet-hedging strategy can be generated by factors either inside or outside an organism. However, sensing the environment and bet hedging are frequently treated as distinct evolutionary strategies. Furthermore, nearly all empirical studies of the molecular underpinnings of bet-hedging strategies to date have focused on internal sources of variability...
February 18, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28213894/controllable-rotating-behavior-of-individual-dielectric-micro-rod-in-a-rotating-electric-field
#3
Weiyu Liu, Yukun Ren, Ye Tao, Yanbo Li, Xiaoming Chen
We report herein controllable rotating behavior of an individual dielectric micro-rod driven by a background rotating electric field. By disposing or removing structured floating microelectrode, the rigid rod suspended in electrolyte solution accordingly exhibits co-field or anti-field rotating motion. In the absence of the ideally polarizable metal surface, the dielectric rod rotates opposite to propagation of electric field, with the measured rotating rate much larger than predicted by Maxwell-Wager interfacial polarization theory incorporating surface conduction of fixed bond charge...
February 18, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28212496/antipsychotic-use-in-dementia
#4
Julia Kirkham, Chelsea Sherman, Clive Velkers, Colleen Maxwell, Sudeep Gill, Paula Rochon, Dallas Seitz
Antipsychotics are necessary for many older adults to treat major mental illnesses or reduce distressing psychiatric symptoms. Current controversy exists over the role of antipsychotics in the management of neuropsychiatric symptoms (NPS) in persons with dementia. Although some NPS may be appropriately and safely treated with antipsychotics, a fine balance must be achieved between the benefits of these medications, which are often modest, and adverse events, which may have significant consequences. Approximately one-third of all persons with dementia are currently prescribed antipsychotic medications, and there is significant variation in the use of antipsychotics across care settings and providers...
March 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28211648/cognitive-development-in-preterm-infants-multi-faceted-deficits-reflect-vulnerability-of-rigorous-neurodevelopmental-pathways
#5
Jessie R Maxwell, Tracylyn R Yellowhair, Akosua Y Oppong, Jenny E Camacho, Jean R Lowe, Lauren L Jantzie, Robin K Ohls
Prematurity remains the major cause of neonatal morbidity and mortality, with 15 million preterm births occurring worldwide in 2010. Infants born less than 37 weeks gestation are at high risk of abnormal neurodevelopmental outcomes, given that the central nervous system is extremely sensitive to an abnormal intra- and extra-uterine environment. Children born preterm have multiple neurodevelopmental sequelae involving dynamic and complex cognitive deficits. Former preterm infants have difficulty with each domain of cognition, including executive function, language, learning and memory, complex attention, perceptual-motor function and social cognition when compared to children born at term...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28208312/dense-plasma-heating-by-crossing-relativistic-electron-beams
#6
N Ratan, N J Sircombe, L Ceurvorst, J Sadler, M F Kasim, J Holloway, M C Levy, R Trines, R Bingham, P A Norreys
Here we investigate, using relativistic fluid theory and Vlasov-Maxwell simulations, the local heating of a dense plasma by two crossing electron beams. Heating occurs as an instability of the electron beams drives Langmuir waves, which couple nonlinearly into damped ion-acoustic waves. Simulations show a factor 2.8 increase in electron kinetic energy with a coupling efficiency of 18%. Our results support applications to the production of warm dense matter and as a driver for inertial fusion plasmas.
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208166/incidence-and-visual-outcomes-of-culture-proven-endophthalmitis-following-dexamethasone-intravitreal-implant
#7
Maxwell S Stem, Bozho Todorich, Yoshihiro Yonekawa, Antonio Capone, George A Williams, Alan J Ruby
Importance: The rate of endophthalmitis following dexamethasone intravitreal implant (DEX) has varied in large clinical trials. Furthermore, to our knowledge, the optimal management of eyes with endophthalmitis associated with DEX has not been established. Objective: To report the incidence of culture-proven endophthalmitis in a single vitreoretinal practice over the course of 3 years and describe the clinical outcomes associated with each case of endophthalmitis...
February 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28202740/health-equity-considerations-for-developing-and-reporting-patient-reported-outcomes-in-clinical-trials-a-report-from-the-omeract-equity-special-interest-group
#8
Jennifer Petkovic, Jennifer L Barton, Caroline Flurey, Niti Goel, Christie M Bartels, Cheryl Barnabe, Maarten P T de Wit, Anne Lyddiatt, Diane Lacaille, Vivian Welch, Annelies Boonen, Beverley Shea, Robin Christensen, Lara J Maxwell, Willemina Campbell, Janet Jull, Karine Toupin-April, Jasvinder A Singh, Charles H Goldsmith, Antoine G Sreih, Christoph Pohl, Catherine Hofstetter, Dorcas E Beaton, Rachelle Buchbinder, Francis Guillemin, Peter S Tugwell
OBJECTIVE: Despite advances integrating patient-centered outcomes into rheumatologic studies, concerns remain regarding their representativeness across diverse patient groups and how this affects equity. The Outcome Measures in Rheumatology (OMERACT) Equity Working Group aims to determine whether and how to address equity issues within the core outcome sets of domains and instruments. METHODS: We surveyed current and previous OMERACT meeting attendees and members of the Campbell and Cochrane Equity Group regarding whether to address equity issues within the OMERACT Filter 2...
February 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28201896/plasmon-coupled-resonance-energy-transfer-a-real-time-electrodynamics-approach
#9
Wendu Ding, Liang-Yan Hsu, George C Schatz
This paper presents a new real-time electrodynamics approach for determining the rate of resonance energy transfer (RET) between two molecules in the presence of plasmonic or other nanostructures (inhomogeneous absorbing and dispersive media). In this approach to plasmon-coupled resonance energy transfer (PC-RET), we develop a classical electrodynamics expression for the energy transfer matrix element which is evaluated using the finite-difference time-domain (FDTD) method to solve Maxwell's equations for the electric field generated by the molecular donor and evaluated at the position of the molecular acceptor...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28195697/block-copolymer-patterning-for-creating-porous-silicon-thin-films-with-tunable-refractive-indices
#10
Hanna H Hulkkonen, Turkka Salminen, Tapio Niemi
We investigated the use of block copolymer (BCP) self-assembly for tuning the optical properties of silicon. We fabricated porous silicon by etching a hexagonally ordered pore pattern onto the surface of silicon wafers using poly(styrene-2-vinylpyridine) to prepare the etch mask. Contrary to typical BCP lithography, we did not need to use a range of different polymers to vary the pore size. We used the dry etching time as a way to increase the pore diameter and thus the porosity. The optical properties of the fabricated porous thin films were characterized by two effective medium approximations...
February 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28192521/acquired-resistance-to-oxaliplatin-is-not-directly-associated-with-increased-resistance-to-dna-damage-in-sk-n-asroxali4000-a-newly-established-oxaliplatin-resistant-sub-line-of-the-neuroblastoma-cell-line-sk-n-as
#11
Emily Saintas, Liam Abrahams, Gulshan T Ahmad, Anu-Oluwa M Ajakaiye, Abdulaziz S H A M AlHumaidi, Candice Ashmore-Harris, Iain Clark, Usha K Dura, Carine N Fixmer, Chinedu Ike-Morris, Mireia Mato Prado, Danielle Mccullough, Shishir Mishra, Katia M U Schöler, Husne Timur, Maxwell D C Williamson, Markella Alatsatianos, Basma Bahsoun, Edith Blackburn, Catherine E Hogwood, Pamela E Lithgow, Michelle Rowe, Lyto Yiangou, Florian Rothweiler, Jindrich Cinatl, Richard Zehner, Anthony J Baines, Michelle D Garrett, Campbell W Gourlay, Darren K Griffin, William J Gullick, Emma Hargreaves, Mark J Howard, Daniel R Lloyd, Jeremy S Rossman, C Mark Smales, Anastasios D Tsaousis, Tobias von der Haar, Mark N Wass, Martin Michaelis
The formation of acquired drug resistance is a major reason for the failure of anti-cancer therapies after initial response. Here, we introduce a novel model of acquired oxaliplatin resistance, a sub-line of the non-MYCN-amplified neuroblastoma cell line SK-N-AS that was adapted to growth in the presence of 4000 ng/mL oxaliplatin (SK-N-ASrOXALI4000). SK-N-ASrOXALI4000 cells displayed enhanced chromosomal aberrations compared to SK-N-AS, as indicated by 24-chromosome fluorescence in situ hybridisation. Moreover, SK-N-ASrOXALI4000 cells were resistant not only to oxaliplatin but also to the two other commonly used anti-cancer platinum agents cisplatin and carboplatin...
2017: PloS One
https://www.readbyqxmd.com/read/28187740/multi-year-school-based-implementation-and-student-outcomes-of-an-evidence-based-risk-reduction-intervention
#12
Bo Wang, Bonita Stanton, Lynette Deveaux, Sonja Lunn, Glenda Rolle, Richard Adderley, Maxwell Poitier, Veronica Koci, Sharon Marshall, Perry Gomez
BACKGROUND: Intervention effects observed in efficacy trials are rarely replicated when the interventions are broadly disseminated, underscoring the need for more information about factors influencing real-life implementation and program impact. Using data from the ongoing national implementation of an evidence-based HIV prevention program [Focus on Youth in The Caribbean (FOYC)] in The Bahamas, this study examines factors influencing teachers' patterns of implementation, the impact of teachers' initial implementation of FOYC, and subsequent delivery of the booster sessions on students' outcomes...
February 10, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28187531/cutaneous-melanoma-attributable-to-solar-radiation-in-cali-colombia
#13
Esther de Vries, Julio R Amador, Carlos Javier Rincon, Claudia Uribe, D Maxwell Parkin
Estimating the population attributable fraction (PAF) of melanomas due to sun exposure is challenging as there are no unexposed population nor reliable exposure data. In high incidence countries, a historic cohort of the South Thames cancer registry was used as a minimally exposed population using the formula PAF = (observed incidence-incidence in minimally exposure)/observed incidence. In this study we apply this method, constructing a minimally exposed cohort for Colombia and also using the historical South Thames data, using melanoma incidence data from the population-based cancer registry of Cali, Colombia for the period 1967-2012...
February 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28187319/quantitative-diagnosis-of-breast-tumors-by-characterization-of-viscoelastic-behavior-of-healthy-breast-tissue
#14
N Madani, A Mojra
The main objective of the present study is to propose a model for characterizing the viscoelastic behavior of the healthy breast tissue. The study population consisted of 60 healthy regions of the breast tissue belonged to 9 female cases. To accomplish this, the attending cases were examined by a robot-assisted device and the mechanical stress resulted from an applied compressive strain was measured. Correlation between the experimental stress and the strain data identifies the breast tissue mechanical behavior...
February 3, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28186652/on-the-contribution-of-curl-free-current-patterns-to-the-ultimate-intrinsic-signal-to-noise-ratio-at-ultra-high-field-strength
#15
Andreas Pfrommer, Anke Henning
The ultimate intrinsic signal-to-noise ratio (SNR) is a coil independent performance measure to compare different receive coil designs. To evaluate this benchmark in a sample, a complete electromagnetic basis set is required. The basis set can be obtained by curl-free and divergence-free surface current distributions, which excite linearly independent solutions to Maxwell's equations. In this work, we quantitatively investigate the contribution of curl-free current patterns to the ultimate intrinsic SNR in a spherical head-sized model at 9...
February 10, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28180079/white-matter-tract-abnormalities-and-antisocial-behavior-a-systematic-review-of-diffusion-tensor-imaging-studies-across-development
#16
REVIEW
Rebecca Waller, Hailey L Dotterer, Laura Murray, Andrea M Maxwell, Luke W Hyde
Antisocial behavior (AB), including aggression, violence, and theft, is thought be underpinned by abnormal functioning in networks of the brain critical to emotion processing, behavioral control, and reward-related learning. To better understand the abnormal functioning of these networks, research has begun to investigate the structural connections between brain regions implicated in AB using diffusion tensor imaging (DTI), which assesses white-matter tract microstructure. This systematic review integrates findings from 22 studies that examined the relationship between white-matter microstructure and AB across development...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28178954/experiencing-aging-or-demystifying-myths-impact-of-different-geriatrics-and-gerontology-teaching-strategies-in-first-year-medical-students
#17
Alessandra Lamas Granero Lucchetti, Giancarlo Lucchetti, Isabella Noceli de Oliveira, Alexander Moreira-Almeida, Oscarina da Silva Ezequiel
BACKGROUND: With the aging of the population comes a greater need for geriatric and gerontology teaching. However, there is currently a dearth of investigations on the impact of different educational methodologies for teaching in this area early in medical courses. The present study aims to determine the impact of two educational strategies on the topic "Geriatrics and Gerontology" ("experiencing aging" and "myths of aging") as compared to a control group (no intervention) on the attitudes, empathy and knowledge of first year medical students...
February 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28177797/development-and-validation-of-a-quantitative-real-time-pcr-assay-for-sapovirus-in-under-five-year-old-children
#18
Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Martina Rosa Brusin, Serena Finotti, Giulia Paderi, Clara Gabiano
Gastroenteritis is a common disease in children, characterized by diarrhea, vomiting, abdominal pain, and fever. Sapovirus (SaV) is a causative agent of acute gastroenteritis although it causes milder illness than rotavirus and norovirus. There is high variability in analytical performance of quantitative PCR-based assays amongst clinical laboratories. This study develops a RT real-time PCR method to detect SaV in fecal specimens collected from under-five-year-old children with acute gastroenteritis. 15 out of 137 (10...
December 2, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28177747/short-term-heat-acclimation-improves-the-determinants-of-endurance-performance-and-5-000-m-running-performance-in-the-heat
#19
Carl Alexander James, Alan J Richardson, Peter W Watt, Ashley G B Willmott, Oliver R Gibson, Neil S Maxwell
This study investigated the effect of 5 days controlled hyperthermia heat acclimation (STHA) on the determinants of endurance performance and 5 km performance in runners, relative to the impairment afforded by moderate heat stress. A control group (CON), matched for total work and power output (2.7 W.kg-1), differentiated thermal and exercise contributions of STHA on exercise performance. Seventeen participants (10 STHA, 7 CON) completed graded exercise tests (GXT) in cool (13°C, 50% RH, pre training) and hot conditions (32°C, 60% RH, pre and post training), as well as 5 km time trials (TT) in the heat, pre and post training...
November 18, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177374/influence-of-dietary-arginine-supplementation-of-sows-during-late-pregnancy-on-piglet-birth-weight-and-sow-and-litter-performance-during-lactation
#20
B E Bass, C L Bradley, Z B Johnson, C E Zier-Rush, R D Boyd, J L Usry, C V Maxwell, J W Frank
Two experiments were conducted to determine the effect of feeding supplemental -Arg during late pregnancy on piglet birth weight and preweaning performance. In Exp. 1, 97 gilts and sows were allotted (gestation d 93) to receive a control diet (CON; 19.8 g standardized ileal digestible [SID] Arg/d) or the CON + 1.0% -Arg (ARG; 46.6 g SID Arg/d). Gilts and sows were weighed on gestation d 93 and 110, 48 h after farrowing, and at weaning. Data, including number born alive, number weaned, individual birth and weaning weight, and placenta weight, were recorded...
January 2017: Journal of Animal Science
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