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https://www.readbyqxmd.com/read/27926866/inflammation-induced-oxidative-stress-mediates-gene-fusion-formation-in-prostate-cancer
#1
Ram S Mani, Mohammad A Amin, Xiangyi Li, Shanker Kalyana-Sundaram, Brendan A Veeneman, Lei Wang, Aparna Ghosh, Adam Aslam, Susmita G Ramanand, Bradley J Rabquer, Wataru Kimura, Maxwell Tran, Xuhong Cao, Sameek Roychowdhury, Saravana M Dhanasekaran, Nallasivam Palanisamy, Hesham A Sadek, Payal Kapur, Alisa E Koch, Arul M Chinnaiyan
Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene TMPRSS2 to the oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity of TMPRSS2 and ERG genes, in combination with DNA breaks, facilitates the formation of TMPRSS2-ERG gene fusions. However, the origins of DNA breaks that underlie gene fusion formation in prostate cancers are far from clear. We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2-ERG gene fusions...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926550/immunonutrition-and-colorectal-surgery
#2
Stephen A McClave, Robert G Martindale, John P Maxwell
No abstract text is available yet for this article.
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27925739/static-einstein-maxwell-black-holes-with-no-spatial-isometries-in-ads-space
#3
Carlos A R Herdeiro, Eugen Radu
We explicitly construct static black hole solutions to the fully nonlinear, D=4, Einstein-Maxwell-anti-de Sitter (AdS) equations that have no continuous spatial symmetries. These black holes have a smooth, topologically spherical horizon (section), but without isometries, and approach, asymptotically, global AdS spacetime. They are interpreted as bound states of a horizon with the Einstein-Maxwell-AdS solitons recently discovered, for appropriate boundary data. In sharp contrast to the uniqueness results for a Minkowski electrovacuum, the existence of these black holes shows that single, equilibrium, black hole solutions in an AdS electrovacuum admit an arbitrary multipole structure...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27921214/external-validity-of-the-chiari-severity-index-and-outcomes-among-pediatric-chiari-i-patients-treated-with-intra-or-extra-dural-decompression
#4
Jared M Pisapia, Maxwell B Merkow, Danielle Brewington, Rosemary E Henn, Leslie N Sutton, Phillip B Storm, Gregory G Heuer
INTRODUCTION: Chiari malformation type-1 (CM-1) may be treated by intradural (ID) or extradural (ED) posterior fossa decompression, although the optimal approach is debated. The Chiari Severity Index (CSI) is a pre-operative metric to predict patient-defined improvement after CM-1 surgery. In this study, we evaluate the results of ID versus ED decompression and assess the external validity of the CSI. METHODS: We performed a retrospective cohort study of pediatric CM-1 patients undergoing decompression at a single academic children's hospital...
December 5, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27919775/behavioral-inhibition-and-behavioral-activation-are-related-to-habituation-of-nociceptive-flexion-reflex-but-not-pain-ratings
#5
P Maxwell Slepian, Christopher R France, Jamie L Rhudy, Lina K Himawan, Yvette M Güereca, Bethany L Kuhn, Shreela Palit
: Habituation (i.e., decreases in responding) and sensitization (i.e., increases in responding) following prolonged or repeated exposures to a fixed stimulus, have been identified as important in adaptation to repeated or prolonged noxious stimulation. Determinants of habituation or sensitization are poorly understood, and experimental investigation of habituation of pain ratings have generally relied on pain reports and statistical techniques that average responses across a group of participants...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27918564/interleukin-33-induced-expression-of-pibf1-by-decidual-b-cells-protects-against-preterm-labor
#6
Bihui Huang, Azure N Faucette, Michael D Pawlitz, Bo Pei, Joshua W Goyert, Jordan Zheng Zhou, Nadim G El-Hage, Jie Deng, Jason Lin, Fayi Yao, Robert S Dewar, Japnam S Jassal, Maxwell L Sandberg, Jing Dai, Montserrat Cols, Cong Shen, Lisa A Polin, Ronald A Nichols, Theodore B Jones, Martin H Bluth, Karoline S Puder, Bernard Gonik, Nihar R Nayak, Elizabeth Puscheck, Wei-Zen Wei, Andrea Cerutti, Marco Colonna, Kang Chen
Preterm birth (PTB) is a leading cause of neonatal death worldwide. Intrauterine and systemic infection and inflammation cause 30-40% of spontaneous preterm labor (PTL), which precedes PTB. Although antibody production is a major immune defense mechanism against infection, and B cell dysfunction has been implicated in pregnancy complications associated with PTL, the functions of B cells in pregnancy are not well known. We found that choriodecidua of women undergoing spontaneous PTL harbored functionally altered B cell populations...
December 5, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27915004/economic-analysis-of-the-nairobi-cancer-registry-implications-for-expanding-and-enhancing-cancer-registration-in-kenya
#7
Anne Korir, Robai Gakunga, Sujha Subramanian, Nathan Okerosi, Gladys Chesumbai, Patrick Edwards, Florence Tangka, Rachael Joseph, Nathan Buziba, Victor Rono, Donald Maxwell Parkin, Mona Saraiya
INTRODUCTION: Cancer registration is an important activity for informing cancer control activities. Cancer registries in Sub-Saharan Africa have limited resources to effectively operate because of competing priorities. To date, there has not been an assessment of the resources and funding needed to perform all the activities essential for cancer registration in Kenya. Evidence will help registries to quantify and advocate for the funds needed to sustain, enhance, and expand high quality cancer registration in Kenya...
November 30, 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27914388/ultrasonic-method-to-characterize-shear-wave-propagation-in-micellar-fluids
#8
Carolina Amador, Bruno L Otilio, Randall R Kinnick, Matthew W Urban
Viscoelastic micellar fluid characteristics have been measured with mechanically generated shear waves and showed good agreement to shear oscillatory methods. In this paper, shear waves in wormlike micellar fluids using ultrasound were successfully generated and detected. Micellar fluids of different concentrations (100, 200, 300, and 400 mM) were studied with ultrasound-based and conventional rheology methods. The measured micellar fluid complex modulus from oscillatory shear tests between 0.001 and 15.91 Hz was characterized with an extended Maxwell fluid model...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27910506/assessment-of-the-measurement-performance-of-the-in-vessel-system-of-gap-6-of-the-iter-plasma-position-reflectometer-using-a-finite-difference-time-domain-maxwell-full-wave-code
#9
F da Silva, S Heuraux, E Ricardo, P Quental, J Ferreira
We conducted a first assessment of the measurement performance of the in-vessel components at gap 6 of the ITER plasma position reflectometry with the aid of a synthetic Ordinary Mode (O-mode) broadband frequency-modulated continuous-wave reflectometer implemented with REFMUL, a 2D finite-difference time-domain full-wave Maxwell code. These simulations take into account the system location within the vacuum vessel as well as its access to the plasma. The plasma case considered is a baseline scenario from Fusion for Energy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908026/resonant-metalenses-for-flexural-waves-in-plates
#10
Andrea Colombi
The dispersion curves of a cluster of closely spaced rods supported by a thin plate are characterised by subwavelength bandgaps and slow group velocities induced by local resonance effects. A recent analytical study [Williams, Roux, Rupin, and Kuperman (2015). Phys. Rev. B 91, 104307], has shown how the slow velocity branch depends, amongst other parameters, on the height of the rods that make up the cluster. Such metamaterial, offering easy-to-tune spatial velocity gradients, is a perfect candidate for building gradient index lenses such as Luneburg, Maxwell, and 90° rotating...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27906365/computation-of-radiation-pressure-force-exerted-on-arbitrary-shaped-homogeneous-particles-by-high-order-bessel-vortex-beams-using-mlfma
#11
Minglin Yang, Yueqian Wu, Kuan Fang Ren, Xinqing Sheng
Due to special characteristics of nondiffraction and self reconstruction, the Bessel beams have attracted wide attention in optical trapping and appear to be a dramatic alternative to Gaussian beams. We present in this paper an efficient approach based on the surface integral equations (SIE) to compute the radiation pressure force (RPF) exerted on arbitrary shaped homogeneous particles by high-order Bessel vortex beam (HOBVB). The incident beam is described by vector expressions perfectly satisfy Maxwell's equations...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906288/eigen-energy-effects-and-non-orthogonality-in-the-quasi-normal-mode-expansion-of-maxwell-equations
#12
Mathias Perrin
We derive a quasi-normal mode theory for three-dimensional scatterers, taking care to remove an hypothesis of weakly dispersive materials implicitely used in previous works. In our approach, the normalized modes remain unchanged, but the analytic expansion coefficients onto the set of QNM are modified. In particular, we take into account in a simple way the non-orthogonality of the modes, and we set up a rigourous frame, to treat the case where several QNMs are excited. Eventally, the complex concept of PML integration, previously introduced, becomes unnecessary, even to compute the QNM mode volume...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27903191/cost-effectiveness-of-stereotactic-radiosurgery-versus-whole-brain-radiation-therapy-for-up-to-10-brain-metastases
#13
Nataniel H Lester-Coll, Arie P Dosoretz, William J Magnuson, Maxwell S Laurans, Veronica L Chiang, James B Yu
OBJECTIVE The JLGK0901 study found that stereotactic radiosurgery (SRS) is a safe and effective treatment option for treating up to 10 brain metastases. The purpose of this study is to determine the cost-effectiveness of treating up to 10 brain metastases with SRS, whole-brain radiation therapy (WBRT), or SRS and immediate WBRT (SRS+WBRT). METHODS A Markov model was developed to evaluate the cost effectiveness of SRS, WBRT, and SRS+WBRT in patients with 1 or 2-10 brain metastases. Transition probabilities were derived from the JLGK0901 study and modified according to the recurrence rates observed in the Radiation Therapy Oncology Group (RTOG) 9508 and European Organization for Research and Treatment of Cancer (EORTC) 22952-26001 studies to simulate the outcomes for patients who receive WBRT...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27899931/melatonin-in-plants-and-plant-culture-systems-variability-stability-and-efficient-quantification
#14
Lauren A E Erland, Abhishek Chattopadhyay, Andrew Maxwell P Jones, Praveen K Saxena
Despite growing evidence of the importance of melatonin and serotonin in the plant life, there is still much debate over the stability of melatonin, with extraction and analysis methods varying greatly from lab to lab with respect to time, temperature, light levels, extraction solvents, and mechanical disruption. The variability in methodology has created conflicting results that confound the comparison of studies to determine the role of melatonin in plant physiology. We here describe a fully validated method for the quantification of melatonin, serotonin and their biosynthetic precursors: tryptophan, tryptamine and N-acetylserotonin by liquid chromatography single quadrupole mass spectrometry (LC-MS) in diverse plant species and tissues...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27899836/impact-of-an-advanced-cardiac-life-support-simulation-laboratory-experience-on-pharmacy-student-confidence-and-knowledge
#15
Whitney D Maxwell, Phillip L Mohorn, Jason S Haney, Cynthia M Phillips, Z Kevin Lu, Kimberly Clark, Alex Corboy, Kelly R Ragucci
Objective. To assess the impact of an advanced cardiac life support (ACLS) simulation on pharmacy student confidence and knowledge. Design. Third-year pharmacy students participated in a simulation experience that consisted of team roles training, high-fidelity ACLS simulations, and debriefing. Students completed a pre/postsimulation confidence and knowledge assessment. Assessment. Overall, student knowledge assessment scores and student confidence scores improved significantly. Student confidence and knowledge changes from baseline were not significantly correlated...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27898608/effect-of-spatial-orientation-of-the-horizontal-semicircular-canal-on-the-vestibulo-ocular-reflex
#16
Rebecca Maxwell, Constantin von Kirschbaum, Claudia Jerin, Nadine Lehnen, Eike Krause, Robert Gürkov
OBJECTIVE: To determine if an alignment of the horizontal semi-circular canal (hSCC) with the plane of rotation would enhance the vestibular-ocular reflex (VOR) gain result as it has been previously suggested. STUDY DESIGN: Comparative study of a physiological vestibular function test in healthy subjects. SETTING: Tertiary referral center for otology and neurotology. PATIENTS: Twenty two healthy volunteers were recruited for this study...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27893952/acceptability-and-impact-of-a-required-palliative-care-rotation-with-prerotation-and-postrotation-observed-simulated-clinical-experience-during-internal-medicine-residency-training-on-primary-palliative-communication-skills
#17
Maxwell T Vergo, Sharona Sachs, Meredith A MacMartin, Kathryn B Kirkland, Amelia M Cullinan, Lisa A Stephens
BACKGROUND: Improving communication training for primary palliative care using a required palliative care rotation for internal medicine (IM) residents has not been assessed. OBJECTIVE: To assess skills acquisition and acceptability for IM residents not selecting an elective. DESIGN: A consecutive, single-arm cohort underwent preobjective structured clinical examination (OSCE) with learner-centric feedback, two weeks of clinical experience, and finally a post-OSCE to crystallize learner-centric take home points...
November 28, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27893640/a-position-paper-the-convergence-of-aging-and-injury-and-the-need-for-a-geriatric-trauma-coalition-geritrac
#18
Zara Cooper, Cathy A Maxwell, Samir M Fakhry, Bellal Joseph, Nancy Lundejberg, Peter Burke, Robert Baracco
No abstract text is available yet for this article.
November 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27893216/assessing-the-fit-of-structural-equation-models-with-multiply-imputed-data
#19
Craig K Enders, Maxwell Mansolf
Multiple imputation has enjoyed widespread use in social science applications, yet the application of imputation-based inference to structural equation modeling has received virtually no attention in the literature. Thus, this study has 2 overarching goals: evaluate the application of Meng and Rubin's (1992) pooling procedure for likelihood ratio statistic to the SEM test of model fit, and explore the possibility of using this test statistic to define imputation-based versions of common fit indices such as the TLI, CFI, and RMSEA...
November 28, 2016: Psychological Methods
https://www.readbyqxmd.com/read/27891258/lyme-carditis-an-interesting-trip-to-third-degree-heart-block-and-back
#20
Maxwell Eyram Afari, Fady Marmoush, Mobeen Ur Rehman, Umama Gorsi, Joseph F Yammine
Carditis is an uncommon presentation of the early disseminated phase of Lyme disease. We present the case of a young female who presented with erythema migrans and was found to have first-degree heart block which progressed to complete heart block within hours. After receiving ceftriaxone, there was complete resolution of the heart block in sequential fashion. Our case illustrates the importance of early recognition and anticipation of progressive cardiac conduction abnormalities in patients presenting with Lyme disease...
2016: Case Reports in Cardiology
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