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https://www.readbyqxmd.com/read/28453667/linearity-of-network-proximity-measures-implications-for-set-based-queries-and-significance-testing
#1
Sean Maxwell, Mark R Chance, Mehmet Koyutürk
Motivation: In recent years, various network proximity measures have been proposed to facilitate the use of biomolecular interaction data in a broad range of applications. These applications include functional annotation, disease gene prioritization, comparative analysis of biological systems and prediction of new interactions. In such applications, a major task is the scoring or ranking of the nodes in the network in terms of their proximity to a given set of 'seed' nodes (e.g. a group of proteins that are identified to be associated with a disease, or are deferentially expressed in a certain condition)...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453492/quantification-of-butyrylcholinesterase-activity-as-a-sensitive-and-specific-biomarker-of-alzheimer-s-disease
#2
Ian R Macdonald, Selena P Maxwell, G Andrew Reid, Meghan K Cash, Drew R DeBay, Sultan Darvesh
Amyloid-β (Aβ) plaques are a neuropathological hallmark of Alzheimer's disease (AD); however, a significant number of cognitively normal older adults can also have Aβ plaques. Thus, distinguishing AD from cognitively normal individuals with Aβ plaques (NwAβ) based on Aβ plaque detection is challenging. It has been observed that butyrylcholinesterase (BChE) accumulates in plaques preferentially in AD. Thus, detecting BChE-associated plaques has the potential as an improved AD biomarker. We present Aβ, thioflavin-S, and BChE quantification of 26 postmortem brain tissues; AD (n = 8), NwAβ (n = 6), cognitively normal without plaques (n = 8), and other common dementias including corticobasal degeneration, frontotemporal dementia with tau, dementia with Lewy bodies, and vascular dementia...
April 28, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28449302/prescribing-safety-assessment-2016-delivery-of-a-national-prescribing-assessment-to-7-343-uk-final-year-medical-students
#3
Simon R J Maxwell, Jamie J Coleman, Lynne Bollington, Celia Taylor, David J Webb
AIM(S): Newly graduated doctors write a large proportion of prescriptions in UK hospitals but recent studies have shown that they frequently make prescribing errors. The Prescribing Safety Assessment (PSA) has been developed as an assessment of competence in relation to prescribing and supervising the use of medicines. This report describes the delivery of the PSA to all UK final-year medical students in 2016 (PSA2016). METHODS: The PSA is a 2-hour online assessment comprising eight sections which cover various aspects of prescribing defined within the outcomes of undergraduate education identified by the UK General Medical Council...
April 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28446694/social-learning-and-the-demise-of-costly-cooperation-in-humans
#4
Maxwell N Burton-Chellew, Claire El Mouden, Stuart A West
Humans have a sophisticated ability to learn from others, termed social learning, which has allowed us to spread over the planet, construct complex societies, and travel to the moon. It has been hypothesized that social learning has played a pivotal role in making human societies cooperative, by favouring cooperation even when it is not favoured by genetical selection. However, this hypothesis lacks direct experimental testing, and the opposite prediction has also been made, that social learning disfavours cooperation...
April 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28444864/dose-reduction-and-alternatives-to-the-phenol-pheromone-in-monitoring-and-management-of-the-grass-grub-costelytra-zealandica
#5
Aimee R Harper, C Rikard Unelius, Richard J Townsend, David Maxwell Suckling
BACKGROUND: Endemic New Zealand grass grub Costelytra zealandica is a pest of introduced pasture that uses phenol as a sex pheromone. The pheromone could be used to monitor and manage grass grub populations, but the irritating properties and toxicity of phenol for human handlers, as well as the possible ecotoxicological effects, pose obstacles to the deployment of the pheromone. This study aimed to limit the use of phenol by dose-response studies and investigation into alternative attractants and synergists to phenol...
April 26, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28442539/retraction-for-mccarthy-et-al-the-ax21-protein-is-a-cell-cell-signal-that-regulates-virulence-in-the-nosocomial-pathogen-stenotrophomonas-maltophilia
#6
Yvonne McCarthy, J Maxwell Dow, Robert P Ryan
No abstract text is available yet for this article.
May 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28441108/novel-clades-of-the-hu-ihf-superfamily-point-to-unexpected-roles-in-the-eukaryotic-centrosome-chromosome-partitioning-and-biologic-conflicts
#7
A Maxwell Burroughs, Gurmeet Kaur, Dapeng Zhang, L Aravind
The HU superfamily of proteins, with a unique DNA-binding mode, has been extensively studied as the primary chromosome-packaging protein of the bacterial superkingdom. Representatives also play a role in DNA-structuring during recombination events and in eukaryotic organellar genome maintenance. However, beyond these well-studied roles, little is understood of the functional diversification of this large superfamily. Using sensitive sequence and structure analysis methods we identify multiple novel clades of the HU superfamily...
April 25, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28440910/subacute-pyridostigmine-exposure-increases-heart-rate-recovery-and-cardiac-parasympathetic-tone-in-rats
#8
Manushree Bharadwaj, Carey Pope, Michael Davis, Stuart Katz, Christian Cook, Lara Maxwell
Heart rate recovery (HRR) describes the rapid deceleration of heart rate after strenuous exercise and is an indicator of parasympathetic tone. A reduction in parasympathetic tone occurs in patients with congestive heart failure, resulting in prolonged HRR. Acetylcholinesterase inhibitors, such as pyridostigmine, can enhance parasympathetic tone by increasing cholinergic input to the heart. The objective of this study was to develop a rodent model of HRR to test the hypothesis that subacute pyridostigmine administration decreases cholinesterase activity and accelerates HRR in rats...
April 25, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28440793/wavelength-dependent-plasmon-mediated-coalescence-of-two-gold-nanorods
#9
Jiunn-Woei Liaw, Wu-Chun Lin, Mao-Kuen Kuo
Plasmon-mediated coalescence of two nearby gold nanorods (NRs) suspended in water induced by the illumination of a linearly polarized (LP) light was studied theoretically. We analyzed the coupled optical forces and torques in terms of Maxwell's stress tensor upon two identical NRs irradiated by a LP plane wave using the multiple multipole method to estimate the optomechanical outcome. Numerical results show that the light-matter interaction can perform attraction or repulsion, depending on their initial configurations...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439861/sample-preparation-protocols-for-protein-abundance-acetylome-and-phosphoproteome-profiling-of-plant-tissues
#10
Gaoyuan Song, Maxwell R McReynolds, Justin W Walley
Peptide mass spectrometry is an invaluable technique to globally quantify the proteome. Central to proteome profiling are efficient methods to extract proteins, digest proteins into peptides, and enrich for posttranslationally modified peptides prior to mass spectrometry. In this chapter, we describe methods to extract proteins, process them into peptides, and optionally enrich for phospho- and acetyl-peptides prior to analysis by mass spectrometry.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28439003/numerical-evidence-for-thermally-induced-monopoles
#11
Peter Wirnsberger, Domagoj Fijan, Roger A Lightwood, Anđela Šarić, Christoph Dellago, Daan Frenkel
Electric charges are conserved. The same would be expected to hold for magnetic charges, yet magnetic monopoles have never been observed. It is therefore surprising that the laws of nonequilibrium thermodynamics, combined with Maxwell's equations, suggest that colloidal particles heated or cooled in certain polar or paramagnetic solvents may behave as if they carry an electric/magnetic charge. Here, we present numerical simulations that show that the field distribution around a pair of such heated/cooled colloidal particles agrees quantitatively with the theoretical predictions for a pair of oppositely charged electric or magnetic monopoles...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28436047/propensity-scores-based-methods-for-estimating-average-treatment-effect-and-average-treatment-effect-among-treated-a-comparative-study
#12
Younathan Abdia, K B Kulasekera, Somnath Datta, Maxwell Boakye, Maiying Kong
Propensity score based statistical methods, such as matching, regression, stratification, inverse probability weighting (IPW), and doubly robust (DR) estimating equations, have become popular in estimating average treatment effect (ATE) and average treatment effect among treated (ATT) in observational studies. Propensity score is the conditional probability receiving a treatment assignment with given covariates, and propensity score is usually estimated by logistic regression. However, a misspecification of the propensity score model may result in biased estimates for ATT and ATE...
April 24, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28434173/the-effect-of-resilience-on-task-persistence-and-performance-during-repeated-exposure-to-heat-pain
#13
P Maxwell Slepian, Christopher R France
The Pain Resilience Scale was recently developed to assess dimensions of resilience critical to pain-related adaptation and was found to predict experimental pain sensitivity in a pain-free population. Pain resilience has also been theoretically linked to behavioral persistence despite pain. To date, however, this hypothesis has not been experimentally tested. To address this gap in the literature, in the current study 105 healthy young adults underwent a baseline administration of the Paced Auditory Serial Addition Test (PASAT), a stressful mental arithmetic task, delivered with somatosensory distraction (i...
April 22, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28434067/sediment-metal-contamination-in-the-kafue-river-of-zambia-and-ecological-risk-assessment
#14
Ethel M'kandawire, Kennedy Choongo, John Yabe, Maxwell Mwase, Ngonda Saasa, Shouta M M Nakayama, Nesta Bortey-Sam, Claudia A Blindauer
Zambia's Kafue River receives wastes from various sources, resulting in metal pollution. This study determined the degree of contamination of 13 metals (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Hg and Pb) in Kafue River sediment and the associated ecological risks at six sites in three different seasons. The level of contamination for most metals showed significant site and seasonal differences. The contamination factor and pollution load index indicated that concentrations of most metals particularly copper (Cu), cobalt (Co), manganese (Mn) and arsenic (As) were very high at sites within the Copperbelt mining area...
April 22, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28433477/novel-mutations-in-the-c-terminal-region-of-gmppb-causing-limb-girdle-muscular-dystrophy-overlapping-with-congenital-myasthenic-syndrome
#15
Sushan Luo, Shuang Cai, Susan Maxwell, Dongyue Yue, Wenhua Zhu, Kai Qiao, Zhen Zhu, Lei Zhou, Jianying Xi, Jiahong Lu, David Beeson, Chongbo Zhao
Mutations in the GMPPB gene may underlie both limb girdle muscular dystrophy (LGMD) and congenital myasthenic syndrome (CMS). Forty-one cases have been reported to date and hotspot mutations are emerging in the Caucasian population. Clinical and pathological features of 5 patients with compound heterozygous GMPPB mutations were collected and retrospectively reviewed. In vitro functional analysis was performed to investigate the pathogeneity of GMPPB variants. The patients presented with proximal limb weakness in their first to second decades...
March 10, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28433444/risk-of-ocular-hypertension-in-adults-with-noninfectious-uveitis
#16
Ebenezer Daniel, Maxwell Pistilli, Srishti Kothari, Naira Khachatryan, R Oktay Kaçmaz, Sapna S Gangaputra, H Nida Sen, Eric B Suhler, Jennifer E Thorne, C Stephen Foster, Douglas A Jabs, Robert B Nussenblatt, James T Rosenbaum, Grace A Levy-Clarke, Nirali P Bhatt, John H Kempen
PURPOSE: To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN: Retrospective, multicenter, cohort study. PARTICIPANTS: Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics. METHODS: Demographic, ocular, and treatment data were extracted from medical records of uveitis cases. MAIN OUTCOME MEASURES: Prevalent and incident OHT with intraocular pressures (IOPs) of ≥21 mmHg, ≥30 mmHg, and increase of ≥10 mmHg from documented IOP recordings (or use of treatment for OHT)...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28430642/immunocompetent-mouse-allograft-models-for-development-of-therapies-to-target-breast-cancer-metastasis
#17
Yuan Yang, Howard H Yang, Ying Hu, Peter H Watson, Huaitian Liu, Thomas R Geiger, Miriam R Anver, Diana C Haines, Philip Martin, Jeffrey E Green, Maxwell P Lee, Kent W Hunter, Lalage M Wakefield
Effective drug development to combat metastatic disease in breast cancer would be aided by the availability of well-characterized preclinical animal models that (a) metastasize with high efficiency, (b) metastasize in a reasonable time-frame, (c) have an intact immune system, and (d) capture some of the heterogeneity of the human disease. To address these issues, we have assembled a panel of twelve mouse mammary cancer cell lines that can metastasize efficiently on implantation into syngeneic immunocompetent hosts...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430501/metric-independence-of-vacuum-and-force-free-electromagnetic-fields
#18
Abraham I Harte
Electromagnetic fields which solve the vacuum Maxwell equations in one spacetime are well known to also be solutions in all spacetimes with conformally related metrics. This provides a sense in which electromagnetism alone cannot be used to measure certain aspects of geometry. We show that there is actually much more which cannot be so measured; relatively little of a spacetime's geometry is in fact imprinted in any particular electromagnetic field. This is demonstrated by finding a much larger class of metric transformations-involving five free functions-which preserve Maxwell solutions both in vacuum, without local currents, and also for the force-free electrodynamics associated with a tenuous plasma...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430257/optical-pressure-and-numerical-simulation-of-optical-forces
#19
Olav Gaute Hellesø
Optical forces on a particle can be calculated using numerical methods and by integrating the Maxwell stress tensor over the surface of the particle. It is shown that this gives considerable numerical noise for the radiation force on particles with refractive index close to that of the surrounding medium and that a large number of mesh elements are necessary. It is found preferable to calculate the force from the local optical pressure, as this gives considerably less noise and requires significantly fewer mesh elements...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28429656/baseline-cognitive-test-performance-and-concussion-like-symptoms-among-adolescent-athletes-with-adhd-examining-differences-based-on-medication-use
#20
Nathan E Cook, Donna S Huang, Noah D Silverberg, Brian L Brooks, Bruce Maxwell, Ross Zafonte, Paul D Berkner, Grant L Iverson
OBJECTIVE: Youth with attention deficit hyperactivity disorder (ADHD) perform more poorly on preseason cognitive testing and report more baseline concussion-like symptoms but prior studies have not examined the influence of medication use on test performance or symptom reporting. This study investigated whether medication use is relevant when interpreting baseline ImPACT® results from student athletes with ADHD. METHOD: Participants were 39,247 adolescent athletes, ages 13-18 (mean age = 15...
April 21, 2017: Clinical Neuropsychologist
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