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https://www.readbyqxmd.com/read/28090693/will-the-needs-based-planning-of-health-human-resources-currently-undertaken-in-several-countries-lead-to-excess-supply-and-inefficiency-rejoinder
#1
Kisalaya Basu, Maxwell Pak
No abstract text is available yet for this article.
January 16, 2017: Health Economics
https://www.readbyqxmd.com/read/28090513/an-update-and-review-of-cell-based-wound-dressings-and-their-integration-into-clinical-practice
#2
REVIEW
Austin Pourmoussa, Daniel J Gardner, Maxwell B Johnson, Alex K Wong
Chronic wounds affect over 4 million individuals and pose a significant burden to the US healthcare system. Diabetes, venous stasis, radiation or paralysis are common risk factors for chronic wounds. Unfortunately, the current standard of care (SOC) has a high relapse rate and these wounds continue to adversely affect patients' quality of life. Fortunately, advances in tissue engineering have allowed for the development of cell-based wound dressings that promote wound healing by improving cell migration and differentiation...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090097/impact-of-the-birkman-method-assessment-on-pharmacy-student-self-confidence-self-perceptions-and-self-awareness
#3
Whitney D Maxwell, Amy D Grant, Patricia H Fabel, Cathy Worrall, Kristy Brittain, Breanne Martinez, Z Kevin Lu, Robert Davis, Georgia H Doran, Bryan Ziegler
Objective. To identify changes in pharmacy student self-confidence, self-perceptions, and self-awareness after completing the Birkman Method assessment and training program. Methods. Survey tools were developed to evaluate students at baseline and following the co-curricular Birkman Method program. Following IRB approval, students participating in the Birkman Method program were recruited for enrollment in this survey-based study. Results. Student self-confidence was high at baseline (mean=4 out of 5) and did not significantly change after Birkman Method testing and training...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28089608/piloting-the-united-kingdom-prescribing-safety-assessment-with-pharmacist-prescribers-in-scotland
#4
Fiona Reid, Ailsa Power, Derek Stewart, Anne Watson, Leon Zlotos, Derna Campbell, Trudi McIntosh, Simon Maxwell
BACKGROUND: Prescribing is a complex task requiring considerable knowledge and skills. The Prescribing Safety Assessment (PSA) was developed by the British Pharmacological Society and the United Kingdom (UK) Medical Schools Council. Between February and June 2014, over 7000 final year medical students undertook the PSA, with an overall pass rate of 94%. Independent prescribing for suitably trained pharmacists was introduced in the UK in 2006. To date there has been little focus on any objective measures of prescribing safety...
January 6, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28088396/pulmonary-alveolar-proteinosis-in-association-with-secondary-hemophagocytic-lymphohistiocytosis
#5
Jenny Lin, Aliva De, Lisa Figueiredo, Rochelle Maxwell, Emily Wasserman, Kelly Adams, Jacqueline Weingarten, Giles Peek, Michael Miksa
Pulmonary alveolar proteinosis (PAP) is a rare diffuse lung disease in the pediatric population. There are currently few cases documenting hemophagocytic lymphohistiocytosis as a cause for secondary PAP. We describe an ex-preterm child with secondary hemophagocytic lymphohistiocytosis, complicated by PAP and hypoxemic respiratory failure.
January 12, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28087451/in-depth-comparative-analysis-of-the-chicken-eggshell-membrane-proteome
#6
Tamer A E Ahmed, Henri-Pierre Suso, Maxwell T Hincke
: The avian eggshell membrane (ESM) is stabilized by extensive cross-linkages, making the identification of its protein constituents technically challenging. Herein, we applied various extraction/solubilization conditions followed by proteomic analysis to characterize the protein constituents of ESM derived from the unfertilized chicken eggs. The egg white and eggshell proteomes (including previous published work) were determined and compared to ESM to identify proteins that are relatively or highly specific to ESM...
January 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28079134/topological-features-of-vector-vortex-beams-perturbed-with-uniformly-polarized-light
#7
Alessio D'Errico, Maria Maffei, Bruno Piccirillo, Corrado de Lisio, Filippo Cardano, Lorenzo Marrucci
Optical singularities manifesting at the center of vector vortex beams are unstable, since their topological charge is higher than the lowest value permitted by Maxwell's equations. Inspired by conceptually similar phenomena occurring in the polarization pattern characterizing the skylight, we show how perturbations that break the symmetry of radially symmetric vector beams lead to the formation of a pair of fundamental and stable singularities, i.e. points of circular polarization. We prepare a superposition of a radial (or azimuthal) vector beam and a uniformly linearly polarized Gaussian beam; by varying the amplitudes of the two fields, we control the formation of pairs of these singular points and their spatial separation...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079023/incidence-and-growth-of-geographic-atrophy-during-5-years-of-comparison-of-age-related-macular-degeneration-treatments-trials
#8
Juan E Grunwald, Maxwell Pistilli, Ebenezer Daniel, Gui-Shuang Ying, Wei Pan, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Maureen G Maguire, Daniel F Martin
PURPOSE: To estimate the incidence, size, and growth rate of geographic atrophy (GA) during 5 years of follow-up among participants in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort within a clinical trial. PARTICIPANTS: Participants included in CATT. METHODS: A total of 1185 CATT participants were randomly assigned to ranibizumab or bevacizumab treatment and to 3 treatment regimens...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28078644/eight-or-12-week-treatment-of-hepatitis-c-with-ledipasvir-sofosbuvir-real-world-experience-in-a-large-integrated-health-system
#9
Jennifer B Lai, Maxwell A Witt, Mary Patricia Pauly, Joanna Ready, Michael Allerton, Suk Seo, David J Witt
BACKGROUND: Second-generation direct-acting antiviral agents are integral to treatment of hepatitis C (HCV) infection. Eight-week courses of ledipasvir/sofosbuvir (LDV/SOF) have been supported in some studies, but data are limited on efficacy in real-world use. Controversy exists regarding applicability of clinical trials to real-world effectiveness. We report virologic responses of patients with HCV genotype 1 infection receiving LDV/SOF for 8 or 12 weeks in a large integrated healthcare system...
January 11, 2017: Drugs
https://www.readbyqxmd.com/read/28077372/extracellular-microrna-signature-in-chronic-kidney-disease
#10
Jagdeesan Muralidharan, Ali Ramezani, Monica J Hubal, Susan Knoblach, Shashi Shrivastav, Sara Karandish, Richard Scott, Nirmal Maxwell, Savas Ozturk, Srinivasan Beddhu, Jeffrey B Kopp, Dominic S Raj
MicroRNAs (miRNAs) are noncoding RNAs that regulate post-transcriptional gene expression. In this study we characterized the circulating and urinary miRNA pattern associated with reduced glomerular filtration rate using Affymetrix GeneChip miR 4.0 in 28 patients with chronic kidney disease (CKD). Top miRNA discoveries from the human studies were validated in an Alb/TGF-β mouse model of CKD, and in rat renal proximal tubular cells (NRK52E) exposed to TGF-β1. Plasma and urinary levels of procollagen III N-terminal propeptide and collagen IV were elevated in patients with decreased estimated glomerular filtration rate (eGFR)...
January 11, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28076705/improving-the-accuracy-of-prenatal-screening-with-dna-copy-number-analysis
#11
LETTER
Charles M Strom, Megan D Maxwell, Renius Owen
No abstract text is available yet for this article.
12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28073638/stimulation-of-the-human-medial-temporal-lobe-between-learning-and-recall-selectively-enhances-forgetting
#12
Maxwell B Merkow, John F Burke, Ashwin G Ramayya, Ashwini D Sharan, Michael R Sperling, Michael J Kahana
BACKGROUND: Direct electrical stimulation applied to the human medial temporal lobe (MTL) typically disrupts performance on memory tasks, however, the mechanism underlying this effect is not known. OBJECTIVE: To study the effects of MTL stimulation on memory performance. METHODS: We studied the effects of MTL stimulation on memory in five patients undergoing invasive electrocorticographic monitoring during various phases of a memory task (encoding, distractor, recall)...
December 29, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/28073100/investigating-the-use-of-appropriation-in-the-writing-of-a-child-with-autism-a-case-study
#13
Jamie Maxwell, Christine Weill, Jack Damico
This case study investigated how a 10year old child with ASD (Autism Spectrum Disorder), Kameron (pseudonym), utilized appropriation as a writing strategy in the context of group therapy. Using the same questions as Lensmire and Beals (1994) in their study of a typically developing third-grader, written products were collected over the course of one semester and analyzed, along with video, audio, and participant observation data, to consider the following questions: 1) Where did the material come from? 2) What was taken? and 3) How was it used? Analysis of the process of Kameron's writing revealed utilization of appropriation as a strategy for 2 of the 4 written products...
December 24, 2016: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28069820/comprehensive-spatial-analysis-of-the-borrelia-burgdorferi-lipoproteome-reveals-a-compartmentalization-bias-toward-the-bacterial-surface
#14
Alexander S Dowdell, Maxwell D Murphy, Christina Azodi, Selene K Swanson, Laurence Florens, Shiyong Chen, Wolfram R Zückert
: The Lyme disease spirochete Borrelia burgdorferi is unique among bacteria in its large number of lipoproteins that are encoded by a small, exceptionally fragmented and predominantly linear genome. Peripherally anchored in either the inner or outer membrane and facing either the periplasm or the external environment, these lipoproteins assume varied roles. A prominent subset functioning as the apparent linchpins of the enzootic tick-vertebrate infection cycle has been explored as vaccine targets...
January 9, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28069774/analogies-between-optical-and-quantum-mechanical-angular-momentum
#15
Gerard Nienhuis
The insight that a beam of light can carry orbital angular momentum (AM) in its propagation direction came up in 1992 as a surprise. Nevertheless, the existence of momentum and AM of an electromagnetic field has been well known since the days of Maxwell. We compare the expressions for densities of AM in general three-dimensional modes and in paraxial modes. Despite their classical nature, these expressions have a suggestive quantum mechanical appearance, in terms of linear operators acting on mode functions...
February 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28069771/helically-twisted-photonic-crystal-fibres
#16
REVIEW
P St J Russell, R Beravat, G K L Wong
Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM)...
February 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28067633/single-mode-tuning-of-the-plasmon-resonance-in-high-density-pillar-arrays
#17
Matthew David Arnold
The Maxwell-Garnett (MG) effective medium model has a pure resonance controlled by volume fraction f, but is usually invalid at high density. I present special 2D structures that match quasistatic MG over the entire range 0<f<1, in several regular and semi-regular arrays, expanding the applicability of MG. A key insight is the direct relationship between optimal surface polarization and surface position. Electrodynamic calculations underline the effect of constituent permittivity on spatial dispersion and required sizes for quasistatic response in various materials...
January 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28062336/comparative-safety-of-morphine-delivered-via-intravenous-route-versus-patient-controlled-analgesia-device-for-pediatric-inpatients
#18
Jennifer Faerber, Wenjun Zhong, Dingwei Dai, Avi Baehr, Lynne G Maxwell, F Wickham Kraemer, Chris Feudtner
BACKGROUND: Although patient-controlled analgesia (PCA) is an effective pain control modality, there is a lack of large studies on PCA safety in pediatric patients. This study compared the delivery of morphine either via intravenous route (morphine IV) or via PCA device (morphine PCA) on risk of cardiopulmonary resuscitation (CPR) and mechanical ventilation (MV) using a large administrative database. METHODS: We assembled a retrospective cohort of pediatric inpatients between 5 and 21 years old in 42 children's hospitals between 2007 and 2011 from the Pediatric Health Information System...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28061001/the-promise-of-molecular-staging-for-the-future
#19
EDITORIAL
George Larry Maxwell, David G Mutch
No abstract text is available yet for this article.
January 6, 2017: Cancer
https://www.readbyqxmd.com/read/28060314/analysis-of-simian-immunodeficiency-virus-specific-cd8-t-cells-in-rhesus-macaques-by-peptide-mhc-i-tetramer-staining
#20
Lucas Gonzalez-Nieto, Aline Domingues, Michael Ricciardi, Martin J Gutman, Helen S Maxwell, Nuria Pedreño-Lopez, Varian Bailey, Diogo M Magnani, Mauricio A Martins
Peptide-major histocompatibility complex class I (pMHC-I) tetramers have been an invaluable tool to study CD8(+) T-cell responses. Because these reagents directly bind to T-cell receptors on the surface of CD8(+) T-lymphocytes, fluorochrome-labeled pMHC-I tetramers enable the accurate detection of antigen (Ag)-specific CD8(+) T-cells without the need for in vitro re-stimulation. Moreover, when combined with multi-color flow cytometry, pMHC-I tetramer staining can reveal key aspects of Ag-specific CD8(+) T-cells, including differentiation stage, memory phenotype, and activation status...
December 23, 2016: Journal of Visualized Experiments: JoVE
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