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https://www.readbyqxmd.com/read/28623951/progressive-respiratory-distress-in-a-42-year-old-hiv-positive-woman-with-systemic-lupus-erythematosus
#1
Katongo Mutengo, Patrice Mukomena, Nason Lambwe, Owen Ngalamika
BACKGROUND: Identifying and treating the cause of pulmonary symptoms in HIV patients with underlying systemic lupus erythematosus (SLE) can be very challenging. Delays in diagnosing active SLE in HIV patients can lead to significant morbidity and even mortality. We report the case of an HIV-positive woman with SLE who presented with severe respiratory distress. CASE PRESENTATION: A 42-year-old HIV-positive woman presented with a 7-month history of anorexia, progressive dyspnoea, and a productive cough...
June 17, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28384925/sle-and-tuberculosis-a-case-series-and-review-of-literature
#2
Prasanta Kumar Bhattacharya, Md Jamil, Aakash Roy, Kishore Kumar Talukdar
Systemic Lupus Erythematosus (SLE) and Tuberculosis (TB) are intricately related with an increase in the risk of TB in SLE. Primary mechanisms pertaining to the increased susceptibility for TB are the inherent immunodeficient state of SLE and use of immunosuppressant agents in the treatment of SLE. We report a case series of five female patients of SLE with TB who presented between January 2015 and December 2015 in a tertiary care teaching hospital in North Eastern India. All the patients were young to middle aged females having SLE with or without lupus nephritis who were on immunosuppressive therapy with corticosteroids, mycophenolate mofetil or cyclophosphamide...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28355724/-a-clinical-analysis-on-fever-of-unknown-origin-in-in-patients-with-systemic-lupus-erythematosus
#3
C F Zhang, R Xu, M T Li, X F Zeng
To investigate the etiology and differential diagnoses of patients with systemic lupus erythematosus (SLE) and fever of unknown origin (FUO). From January 2012 to December 2014, a total of 928 SLE patients were admitted to Peking Union Medical College Hospital.Only 50 patients were combined with FUO (5.4%). The most common reason of fever was caused by infections(33 cases, 66.0%), including bacterial infection in 17 cases with 5 tuberculosis, viral infection in 11 cases, and fungal infection in 5 cases.The second reason offever was due to poor disease control or recurrence in 17 patients (34...
April 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28286903/the-risk-of-tuberculosis-in-sle-patients-from-an-asian-tertiary-hospital
#4
Yong Yang, Julian Thumboo, Ban Hock Tan, Thuan Tong Tan, Chern Hui Jeffrey Fong, Han Seong Ng, Kok Yong Fong
Systemic lupus erythematosus (SLE) has been associated with increased risk of tuberculosis (TB). However, little is known about the extent and risk factors for TB among Asian patient with SLE. We aimed to assess the rate of TB in patients with SLE, and investigate the risk of SLE on TB development using hospital administrative database. This is an historical cohort study of hospital discharge database from 2004 to 2011 to identify cases with SLE and TB using International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification (ICD-9-AM) codes...
June 2017: Rheumatology International
https://www.readbyqxmd.com/read/28036316/post-delivery-mycobacterium-tuberculosis-infection-misdiagnosed-as-systemic-lupus-erythematosus
#5
Li Yu Ting, Bikash Shrestha, Yi Lu Lu, Fu Ping
Tuberculosis is a common infectious mycobacterial disease having a wide range of clinical and serological manifestations that are similar to rheumatic disease. Differential diagnosis is a crucial aspect in any rheumatic disease as many other infectious diseases portray clinical similarities and autoantibody positivity. Our case report illustrates of a young woman just after the delivery of a child presented an unusual case of extrapulmonary tuberculosis infection initially misdiagnosed as systemic lupus erythematosus (SLE)...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27891378/isoniazid-induced-lupus-presenting-as-oral-mucosal-ulcers-with-pancytopenia
#6
Ria Shah, Padmaraj Ankale, Kanishk Sinha, Aparna Iyer, T K Jayalakshmi
Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug treatment for pulmonary and knee joint tuberculosis...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27730777/ovarian-insufficiency-is-major-short-term-toxicity-in-systemic-lupus-erythematosus-patients-treated-with-cyclophosphamide
#7
Gurmeet Singh, Ramnath Misra, Amita Aggarwal
OBJECTIVE: To study the toxicities associated with pulse cyclophosphamide therapy and to compare them with patients without cyclophosphamide exposure. METHODS: In this retrospective cross-sectional observational study Systemic Lupus Erythematosus (SLE) patients who had received immunosuppressive agents in the past were interviewed in the Out Patient Department for drug related toxicities. Patients were asked about the any history of tuberculosis, herpes zoster, hemorrhagic cystitis or ovarian toxicity in the past...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27432810/genetic-selection-pressure-in-tlr9-gene-may-enforce-risk-for-sle-in-indian-tamils
#8
J H Yusuf, D Kaliyaperumal, M Jayaraman, G Ramanathan, P Devaraju
Objectives Lupus is a classical systemic autoimmune disease with genetics as one of the well known causative factors for the disease pathogenesis. Toll-like receptors are the major pattern recognition receptors associated with innate immunity and also act as an interface with the adaptive immunity. Genetic polymorphisms in genes encoding TLRs were implicated in the development of infections, malignancies and autoimmune diseases. TLR9 is a member of TLR family, and recognizes the CpG DNA motifs of pathogens...
March 2017: Lupus
https://www.readbyqxmd.com/read/27267647/miliary-tuberculosis-a-severe-opportunistic-infection-in-juvenile-systemic-lupus-erythematosus-patients
#9
Priscilla S Freire, João D Montoni, Aline S M Ribeiro, Heloísa H Marques, Thais Mauad, Clovis A Silva
INTRODUCTION: One of the main issues in juvenile systemic lupus erythematosus (JSLE) patients is infection, such as tuberculosis (TB). Of note, SLE patients are susceptible to pulmonary and extrapulmonary TB. However, to our knowledge, this contagious disease was rarely reported in pediatric lupus population, particularly diffuse or miliary TB. Therefore, from January 1983 to December 2011, 5,635 patients were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for SLE...
May 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27149470/a-rare-case-of-disseminated-tuberculosis-of-the-bone-marrow-in-systemic-lupus-erythematosus-case-report
#10
Dongying Chen, Zheng Yang, Ying Yang, Zhongping Zhan, Xiuyan Yang
Patients with systemic lupus erythematosus (SLE) are susceptible to tuberculosis (TB), especially in endemic areas such as China. The variable and nonspecific clinical features of disseminated TB often leads to an erroneous or misdiagnosis. When a patient presents with TB of the bone marrow, the clinical condition is more perplexing and the prognosis is typically poor. Till now, there is no case report after apatinib came in the market.Here, we report a case of TB of the bone marrow accompanied with SLE. The patient exhibited remarkable features, including widespread lesions in the lungs, spinal vertebrae, sacrum, and ilium that were found to be consistent with TB of the bone marrow after histopathological examination...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27073889/low-density-granulocytes-are-elevated-in-mycobacterial-infection-and-associated-with-the-severity-of-tuberculosis
#11
Yating Deng, Jianqing Ye, Qing Luo, Zhikun Huang, Yiping Peng, Guoliang Xiong, Yang Guo, Hong Jiang, Junming Li
Tuberculosis remains a global health problem caused by infection with Mycobacterium tuberculosis. Numerous studies have established a close correlation between the development of tuberculosis and the roles of neutrophils. Recently, a distinct population of CD15+ granulocytes was found to be present in the peripheral blood mononuclear cell (PBMC) fraction in humans. This population of granulocytes, termed low-density granulocytes (LDGs), was reported to be elevated and associated with disease activity or severity in a number of different conditions including SLE, asthma and HIV infection...
2016: PloS One
https://www.readbyqxmd.com/read/26985011/concordance-between-the-tuberculin-skin-test-and-interferon-gamma-release-assay-igra-for-diagnosing-latent-tuberculosis-infection-in-patients-with-systemic-lupus-erythematosus-and-patient-characteristics-associated-with-an-indeterminate-igra
#12
COMPARATIVE STUDY
H Cho, Y W Kim, C-H Suh, J-Y Jung, Y-J Um, J-H Jung, H-A Kim
OBJECTIVE: We investigated the agreement between the tuberculin skin test (TST) and the QuantiFERON-TB gold (QFT-G) assay in the diagnosis of latent tuberculosis infection (LTBI) in patients with systemic lupus erythematosus (SLE). Furthermore, we evaluated the factors associated with indeterminate results in the QFT-G assay in patients with SLE. METHODS: We enrolled 136 patients with SLE prospectively, and compared them to 66 patients with rheumatoid arthritis (RA)...
October 2016: Lupus
https://www.readbyqxmd.com/read/26951251/infection-and-lupus-which-causes-which
#13
REVIEW
Sarah Doaty, Harsh Agrawal, Erin Bauer, Daniel E Furst
Infection is a leading cause of morbidity and mortality among patients with systemic lupus erythematous (SLE). Dysfunction of the innate and adaptive immune systems increases the risk of infection in patients with SLE. Infectious agents have also been theorized to play a role in the pathogenesis of SLE. This article summarizes our current knowledge of the infectious risk SLE patients face as a result of their underlying disease including abnormal phagocytes and T cells as well as the increased risk of infection associated with immunosuppressive agents used to treat disease...
March 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26950245/common-polymorphisms-in-il-27-genes-may-contribute-to-risk-of-various-human-diseases-in-asian-populations-a-meta-analysis
#14
Yun-Feng Zhang, An-Di Zhao
BACKGROUND: Genetic variations in the IL-27 gene have been proven to be associated with various types of human cancers and diseases. The purpose of the current study was to clarify the associations of the IL-27 rs153109 A>G and rs181206 T>C variants with human diseases using a meta-analysis study. MATERIAL/METHODS: A comprehensive electronic and manual search was carried out to find potential eligible studies. The effect size was represented by the unadjusted odds ratios (ORs)...
March 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26870787/distinct-transcriptional-and-anti-mycobacterial-profiles-of-peripheral-blood-monocytes-dependent-on-the-ratio-of-monocytes-lymphocytes
#15
Vivek Naranbhai, Helen A Fletcher, Rachel Tanner, Matthew K O'Shea, Helen McShane, Benjamin P Fairfax, Julian C Knight, Adrian V S Hill
The ratio of monocytes and lymphocytes (ML ratio) in peripheral blood is associated with tuberculosis and malaria disease risk and cancer and cardiovascular disease outcomes. We studied anti-mycobacterial function and the transcriptome of monocytes in relation to the ML ratio. Mycobacterial growth inhibition assays of whole or sorted blood were performed and mycobacteria were enumerated by liquid culture. Transcriptomes of unstimulated CD14 + monocytes isolated by magnetic bead sorting were characterised by microarray...
November 2015: EBioMedicine
https://www.readbyqxmd.com/read/26656550/-the-impact-of-early-detection-of-primary-drug-resistant-tuberculosis-based-on-the-treatment-outcome-in-patients-at-penitentiary-institutions-of-azerbaijan
#16
N Rahmanov, E Mamedbekov, R Mehtiev, E Kurbanova
Retrospective research (2007-2012) was conducted on 500 patients with drug-resistant primary tuberculosis treated by DOTS-plus PS SLE Azerbaijan. The aim of the study was to establish a new strategy of identifying TB within the penitentiary system, aimed at early determination of the disease and soonest commencement of treatment of the patients with second generation medications. Results of the study as well as the analysis of multivariable indicators have confirmed that passive identification (ORa=1.13) of the patients and delayed commencement of the treatment by more than 3 months from determination (ORa=1...
November 2015: Georgian Medical News
https://www.readbyqxmd.com/read/26413186/vitamin-d-and-inflammation
#17
REVIEW
John J Cannell, William B Grant, Michael F Holick
Several studies found an inverse relationship between 25-hydroxyvitamin D [25(OH)D] and markers of inflammation. A controversy exists as to whether vitamin D lowers inflammation or whether inflammation lowers 25(OH)D concentrations. Certainly 25(OH)D concentrations fall after major surgery. However, is this due to inflammation lowering 25(OH)D or is 25(OH)D being metabolically cleared by the body to quell inflammation. We searched the literature and found 39 randomized controlled trials (RCT) of vitamin D and markers of inflammation...
January 2014: Dermato-endocrinology
https://www.readbyqxmd.com/read/26281486/neurological-manifestations-in-a-patient-of-kikuchi-s-disease
#18
Marina Vaz, Carmen M Pereira, Sindhoora Kotha, Jamina Oliveira
Kikuchi's disease is a rare condition that mainly presents in young females along with lymphadenitis. Involvement of the nervous system is rare. We report a young female who presented with fever, headache, vomiting, lymphadenopathy and neurological manifestations in the form of aseptic meningitis, ataxia and paraparesis. Since the disease can be mistaken clinically and histologically for SLE, lymphoma and tuberculosis it is important to differentiate it from these conditions. Also our case emphasizes the importance of recognising this disorder in diagnosing patients with meningitis...
November 2014: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/26275903/cohort-profile-systemic-lupus-erythematosus-in-sweden-the-swedish-lupus-linkage-slink-cohort
#19
Elizabeth V Arkema, Julia F Simard
PURPOSE: A cohort of individuals with systemic lupus erythematosus (SLE) was identified through linkage of several national registers to investigate important epidemiological questions using not only population-based data to minimise selection bias, but also to identify matched comparators from the general population to serve as controls. This cohort was established to overcome the general dearth of data in SLE epidemiology. PARTICIPANTS: All individuals registered in Sweden with a personal identity number and who have obtained medical care at any hospital or public non-primary outpatient specialist care with suspected SLE were identified...
2015: BMJ Open
https://www.readbyqxmd.com/read/26245637/first-report-of-multi-drug-resistant-tuberculosis-in-a-systemic-lupus-erythematosus-patient
#20
Kunchok Dorjee, Kerry L Dierberg, Tsetan D Sadutshang, Arthur L Reingold
BACKGROUND: Treatment of a multi-drug resistant tuberculosis (MDR-TB) patient is clinically challenging, requiring a minimum of 18 months of therapy. Its occurrence in a systemic lupus erythromatosus (SLE) patient may complicate management of both MDR-TB and SLE. This is the first descriptive report of MDR-TB in an SLE patient. CASE PRESENTATION: A 19-year old female receiving long-term prednisolone for SLE was diagnosed with MDR-TB. She was started on MDR-TB treatment regimen and prednisolone was replaced with azathioprine...
2015: BMC Research Notes
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