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https://www.readbyqxmd.com/read/30230983/long-noncoding-rna-signatures-induced-by-toll-like-receptor-7-and-type-i-interferon-signaling-in-activated-human-plasmacytoid-dendritic-cells
#1
Rochelle C Joslyn, Adriana Forero, Richard Green, Stephen E Parker, Ram Savan
Long noncoding RNAs (lncRNAs) exhibit highly lineage-specific expression and act through diverse mechanisms to exert control over a wide range of cellular processes. lncRNAs can function as potent modulators of innate immune responses through control of transcriptional and posttranscriptional regulation of mRNA expression and processing. Recent studies have demonstrated that lncRNAs participate in the regulation of antiviral responses and autoimmune disease. Despite their emerging role as immune mediators, the mechanisms that govern lncRNA expression and function have only begun to be characterized...
September 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/30225916/all-cause-and-cause-specific-mortality-trends-of-end-stage-renal-disease-due-to-lupus-nephritis-from-1995-to-2014
#2
April Jorge, Zachary S Wallace, Yuqing Zhang, Na Lu, Karen H Costenbader, Hyon K Choi
BACKGROUND/OBJECTIVE: The premature mortality among patients with end-stage renal disease due to lupus nephritis (LN-ESRD) persisted in the U.S. between 1995 and 2006. We extended the analysis until 2014 for the latest trend and also examined key cause-specific mortality trends. METHODS: Using the national registry of ESRD patients, we identified all patients with incident LN-ESRD between January 1, 1995 and December 31, 2014, divided into four five-year cohorts by calendar year of ESRD onset (1995-1999, 2000-2004, 2005-2009, 2010-2014)...
September 18, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30223775/disseminated-extrapulmonary-legionella-pneumophila-infection-presenting-with-panniculitis-case-report-and-literature-review
#3
Maria N Chitasombat, Natta Ratchatanawin, Yingluck Visessiri
BACKGROUND: Legionellosis is a well-known cause of pneumonia. Primary cutaneous and subcutaneous infection caused by Legionella pneumophila is rare and the diagnosis is challenging. CASE PRESENTATION: A 38-year-old Thai woman with systemic lupus erythematosus and myasthenia gravis treated with prednisolone and azathioprine presented to our hospital with low-grade fever, diarrhea, and indurated skin lesions on both thighs. Initial examination showed plaques on both inner thighs...
September 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30215770/pharmacokinetics-and-pharmacogenomics-of-mycophenolic-acid-and-its-clinical-correlations-in-maintenance-immunosuppression-for-lupus-nephritis
#4
Desmond Y H Yap, Chun Hay Tam, Susan Yung, Sunny Wong, Colin S O Tang, Temy M Y Mok, Catherine K Y Yuen, Maggie K M Ma, Chak Sing Lau, Tak Mao Chan
Background: There is little data on mycophenolic acid (MPA) pharmacokinetics and pharmacogenomics and optimal MPA exposure in lupus nephritis (LN) patients during long-term maintenance. Methods: We measured blood MPA levels at 1, 2, 4, 8, 10 and 12-h post-dose (i.e. C1, C2, C4, C8, C10 and C12) in 88 stable LN patients receiving maintenance prednisolone and mycophenolate mofetil, repeated every 6 months. The relationship between MPA exposure and single nucleotide polymorphisms (SNPs) of adenosine triphosphate-binding cassette subfamily C member 2 (ABCC2; rs2273697, rs3740066, rs717620 and rs17222723), organic anion-transporting polypeptides (OATPs; rs7311358 and rs4149117) and uridine diphosphate glucuronosyltransferase (UGT; rs17863762, rs6714486, rs17868320 and rs72551330) was also investigated...
September 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30213761/systemic-lupus-erythematosus-a-new-autoimmune-disorder-in-kabuki-syndrome
#5
Todor Arsov, Mario Sestan, Nastasia Cekada, Marijan Frkovic, Dan Andrews, Yuke He, Nan Shen, Carola G Vinuesa, Marija Jelusic
We report a case of a 17-year-old Caucasian girl with syndromic features of clinically unrecognized Kabuki syndrome (KS), who developed systemic lupus erythematosus (SLE). Diagnosis of KS was established after whole exome sequencing (WES) and detection of de novo frameshift 1bp deletion in histone-lysine N-methyltransferase 2D gene (KMT2D). The pathogenic variant in exon 34 (c.8626delC: 55 reads C, 56 reads delC), has not been described previously and is predicted to truncate the protein (p.Gln2876Serfs*34) resulting in KMT2D loss of function...
September 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/30213699/the-role-of-dietary-sodium-on-autoimmune-diseases-the-salty-truth
#6
REVIEW
Kassem Sharif, Howard Amital, Yehuda Shoenfeld
Autoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Sodium, a major constituent of salt is essential for mammalian physiology. However, high salt intake may play a role in the development of autoimmune diseases...
September 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30199535/lupus-acceleration-by-a-mavs-activating-rna-virus-requires-endosomal-tlr-signaling-and-host-genetic-predisposition
#7
Rosana Gonzalez-Quintial, Anthony Nguyen, Dwight H Kono, Michael B A Oldstone, Argyrios N Theofilopoulos, Roberto Baccala
Viruses have long been implicated in the pathogenesis of autoimmunity, yet their contribution remains circumstantial partly due to the lack of well-documented information on infections prior to autoimmune disease onset. Here, we used the lymphocytic choriomeningitis virus (LCMV) as a model to mechanistically dissect the impact of viral infection on lupus-like autoimmunity. Virus persistence strongly enhanced disease in mice with otherwise weak genetic predisposition but not in highly predisposed or non-autoimmune mice, indicating a synergistic interplay between genetic susceptibility and virus infection...
2018: PloS One
https://www.readbyqxmd.com/read/30185361/outcomes-of-rituximab-therapy-in-refractory-lupus-a-meta-analysis
#8
Fatma Alshaiki, Elaf Obaid, Abdulqader Almuallim, Rabab Taha, Hadeel El-Haddad, Hani Almoallim
OBJECTIVE: Conventional treatment of systemic lupus erythematosus (SLE) and lupus nephritis (LN) is associated with damage accrual, hence increased morbidity rate. Off-label use of rituximab (RTX) has shown significant promise in this patient group; however, data are still controversial. We aimed to analyze the outcomes of RTX therapy in refractory lupus using a meta-analysis approach. METHODS: Electronic search of the medical literature was conducted using a combination of relevant keywords to retrieve studies on the safety and efficacy of RTX in SLE and LN patients...
July 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30185096/incidence-and-variables-associated-with-short-and-long-term-mortality-in-patients-with-systemic-lupus-erythematosus-and-sepsis-admitted-in-intensive-care-units
#9
E Abramovich, O Barrett, J Dreiher, V Novack, M Abu-Shakra
Background Infections are common among patients with systemic lupus erythematosus (SLE), and are associated with increased morbidity and mortality. Objectives To determine whether SLE is an independent risk factor for short- and long-term mortality in patients admitted to an intensive care unit (ICU) with sepsis, and to identify the characteristics of SLE patients admitted to an ICU with sepsis. Methods A retrospective age- and sex-matched cohort study, based on data of the SEPSIS-ISR (Sepsis Israel) Registry, an ongoing study that collects data on all patients admitted with sepsis to the ICUs...
September 5, 2018: Lupus
https://www.readbyqxmd.com/read/30177132/frequency-of-pathologic-changes-in-the-oral-cavity-in-patients-subjected-to-long-term-pharmacologic-immunosuppressive-therapy-after-kidney-liver-and-hematopoietic-cell-transplantation
#10
M Osiak, D Szubińska-Lelonkiewicz, P Wychowański, E Karakulska-Prystupiuk, W Jędrzejczak, A Wojtowicz, P Fiedor
INTRODUCTION: Patients subjected to long-term immunosuppressive therapy after organ and cells transplantation are more susceptible than healthy people to the development of the pathologic changes in the oral cavity, including precancerous lesions, oral cancers, lesions following viral infections (herpes simplex virus, Epstein-Barr virus, and cytomegalovirus), fungal infections mainly caused by Candida albicans, drug-induced gingival overgrowth, stomatitis, and tongue disorders. MATERIAL AND METHODS: Clinical case material included 38 patients after kidney, liver, or blood-forming cells transplantation subjected to various immunosuppressive therapy schemes...
September 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30173154/improving-the-combination-pneumococcal-vaccination-rate-in-systemic-lupus-erythematosus-patients-at-an-adult-rheumatology-practice
#11
Shivani Garg, Katina Tsagaris, Raluca Cozmuta, Aliza Lipson
OBJECTIVE: The risk of developing invasive pneumococcal infection is 13 times higher in patients with systemic lupus erythematosus (SLE) in comparison with the general population. The US Centers for Disease Control and Prevention anticipates a US$7.6 million medical cost reduction by providing pneumococcal vaccination. The objective of this study was to improve the rate of combination pneumococcal vaccination (pneumococcal polysaccharide vaccine 23 + pneumococcal conjugate vaccine 13) in patients with SLE in our adult academic rheumatology practice...
September 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/30173146/complement-consumption-in-systemic-lupus-erythematosus-leads-to-decreased-opsonophagocytosis-in-vitro
#12
Amanda Mitander, Ying Fei, Estelle Trysberg, Majd Mohammad, Zhicheng Hu, Egidija Sakiniene, Rille Pullerits, Tao Jin
OBJECTIVE: Infections remain a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). The high prevalence of infections in SLE is attributed to both the disease and its treatments. The complement system plays an important role in host immune responses against invading microorganisms. We sought to provide the experimental and clinical evidence supporting the hypothesis that low levels of complement factors cause defective complement-mediated opsonization in patients with SLE...
September 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/30170530/secondary-syphilis-masquerading-as-lupus-vulgaris-in-an-hiv-infected-patient-a-diagnosis-suggested-by-histology
#13
Giovanni Genovese, Gianluca Nazzaro, Antonella Coggi, Raffaele Gianotti, Stefano Ramoni, Marco Cusini
We report a case of secondary syphilis mimicking lupus vulgaris in an HIV-infected patient. A 21-year-old Brazilian man presented with a two-month history of asymptomatic cutaneous lesions accompanied by fever and fatigue. Dermatological evaluation revealed an erythematous, crusted, large plaque on the neck with the 'apple jelly' sign on diascopy and two smaller scaly elements on the trunk and left palm. Bacteriological examinations for bacteria and mycobacteria gave negative results. Histology revealed psoriasiform epidermal hyperplasia and dermal lymphoplasmacytic infiltrate...
August 31, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/30168847/autoimmune-skin-disease-among-dermatology-outpatients-in-botswana-a-retrospective-review
#14
Pamela N Madu, Victoria L Williams, Megan H Noe, Bernard G Omech, Carrie L Kovarik, Karolyn A Wanat
BACKGROUND: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana. METHODS: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. New diagnoses of cutaneous lupus erythematosus, systemic lupus erythematosus (SLE) with cutaneous involvement, dermatomyositis, systemic sclerosis, lichen sclerosus, bullous pemphigoid, pemphigus foliaceus, pemphigus vulgaris, and pemphigus vegetans were identified...
August 31, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/30157715/invasive-aspergillosis-in-patients-with-systemic-lupus-erythematosus-a-retrospective-study-on-clinical-characteristics-and-risk-factors-for-mortality
#15
M L Hung, H T Liao, W S Chen, M H Chen, C C Lai, C Y Tsai, D M Chang
Objective The objective of this paper is to analyze the clinical features, outcomes, mortality risk factors, and all-cause mortalities of invasive aspergillosis (IA) in patients with systemic lupus erythematosus (SLE). Methods Medical records were reviewed to identify SLE patients with IA from January 2006 to June 2017, at Taipei Veterans General Hospital, Taiwan. A total of 6714 SLE patients were included. Clinical/laboratory parameters and treatment outcomes were analyzed. Results Four patients (19.0%) had definite and 17 had probable (81...
August 29, 2018: Lupus
https://www.readbyqxmd.com/read/30155387/paraneoplastic-mononeuritis-multiplex-a-unique-presentation-of-non-hodgkin-lymphoma
#16
Abdul Ahad E Sheikh, Abu Baker Sheikh, Usman Tariq, Fasih Sami Siddiqui, Waseem T Malik, Haris M Rajput, Imran Ahmad
Mononeuritis multiplex (MM) is a common variant of a peripheral neuropathy which is characterized by neurological discrepancies that afflict two noncontiguous nerve systems. It is mostly associated with systemic illnesses such as diabetes mellitus, vasculitis, systemic lupus erythematosus (SLE), viral infections including human immunodeficiency virus (HIV) and paraneoplastic syndromes. Lymphoma is a common antecedent to paraneoplastic syndromes that cause peripheral neuropathies but a specific presentation of MM is a rare predicament per our literature analysis...
June 26, 2018: Curēus
https://www.readbyqxmd.com/read/30151719/all-cause-hospitalizations-in-systemic-lupus-erythematosus-from-a-single-medical-center-in-israel
#17
Ofer Levy, Andrey Markov, Yulia Drob, Ilia Maslakov, Moshe Tishler, Mirit Amit-Vazina
OBJECTIVE: Clinical features of systemic lupus erythematosus (SLE) have been described from different geographical regions in the world. The aim of this study was to obtain local and contemporary data on all-cause hospitalizations of SLE patients in an Israeli Medical Center. METHODS: This is a retrospective observational single-center study. Revision of medical records of hospitalized lupus patients during 5-year period (January 2012-December 2016) was performed...
October 2018: Rheumatology International
https://www.readbyqxmd.com/read/30134810/serologic-features-of-cohorts-with-variable-genetic-risk-for-systemic-lupus-erythematosus
#18
Jyotsna Bhattacharya, Karalyn Pappas, Bahtiyar Toz, Cynthia Aranow, Meggan Mackay, Peter K Gregersen, Ogobara Doumbo, Abdel Kader Traore, Martin L Lesser, Maureen McMahon, Tammy Utset, Earl Silverman, Deborah Levy, William J McCune, Meenakshi Jolly, Daniel Wallace, Michael Weisman, Juanita Romero-Diaz, Betty Diamond
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3-4 fold greater incidence of SLE than Caucasians. Paradoxically, West Africans in sub-Saharan Africa appear to have a low incidence of SLE, and some studies suggest a milder disease with less nephritis. In this study, we analyzed sera from African American female SLE patients and four other cohorts, one with SLE and others with varying degrees of risk for SLE in order to identify serologic factors that might correlate with risk of or protection against SLE...
June 1, 2018: Molecular Medicine
https://www.readbyqxmd.com/read/30131931/hemophagocytic-lymphohistiocytosis-complicating-systemic-sarcoidosis
#19
Omar Abughanimeh, Ayman Qasrawi, Mouhanna Abu Ghanimeh
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterized by histiocyte proliferation and hemophagocytosis. Primary HLH is caused by genetic defects, whereas secondary HLH occurs in the setting of underlying diseases, such as infections, malignancies, or rheumatic diseases. Rheumatic diseases, such as systemic juvenile arthritis or systemic lupus erythematosus, have been associated with HLH. However, the association between sarcoidosis and HLH has been rarely reported in the literature...
June 19, 2018: Curēus
https://www.readbyqxmd.com/read/30130445/herpes-zoster-vaccination-in-systemic-lupus-erythematosus-the-current-status
#20
Chi Chiu Mok
Among the inflammatory rheumatic diseases, SLE is associated with the highest risk of herpes zoster reactivation relative to age. The reported incidence of herpes zoster infection in SLE ranges from 6.4 to 91.4/1000 patient-years, with main risk factors being major organ disease, immunosuppressive and biological therapies. Although herpes zoster in SLE is manageable with anti-viral treatment, complications such as superimposed bacterial infection, post-herpetic neuralgia may ensue. The low rate of herpes zoster vaccination in SLE is related to the lack of awareness, fear of the risk of vaccine-induced infection and disease flare, cost, as well as the lack of explicit recommendations of vaccine use for the paucity of data in immunocompromised and younger subjects...
August 21, 2018: Human Vaccines & Immunotherapeutics
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