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synchronous ovarian and endometrial cancer

Francesca Falcone, Giuseppe Laurelli, Simona Losito, Marilena Di Napoli, Vincenza Granata, Stefano Greggi
OBJECTIVE: To report our 15-year institutional experience of fertility-sparing treatment in young patients with early endometrial cancer (EC) treated by combined hysteroscopic resection and progestin therapy. METHODS: Twenty-eight patients (stage IA, G1 and 2 endometrioid EC) wishing to preserve their fertility were enrolled into this prospective study. Hysteroscopic resection was used to resect the tumor, endometrium adjacent to the tumor and myometrium underlying the tumor...
August 8, 2016: Journal of Gynecologic Oncology
Gul Kanyilmaz, Meryem Aktan, Mehmet Koc, Siddika Findik
There are limited data about the cutaneous metastases of gynecological malignancies in the literature. Based on this limited number of studies, cutaneous metastases from gynecological malignancies are uncommon occurrences. Cutaneous metastases from the synchronous endometrioid carcinoma of the uterine corpus and bilateral ovaries arising from endometriosis are extremely rare. Herein, we report a 51-year-old woman with FIGO Stage 1A Grade 1 endometrial endometrioid-type adenocarcinoma and synchronous bilateral Stage 1B ovarian endometrioid-type adenocarcinoma who presented 34 months following total abdominal hysterectomy and bilateral salpingo-oophorectomy with skin metastases...
2016: Case Reports in Oncological Medicine
Angel Chao, Ren-Chin Wu, Shih-Ming Jung, Yun-Shien Lee, Shu-Jen Chen, Yen-Lung Lu, Chia-Lung Tsai, Chiao-Yun Lin, Yun-Hsin Tang, Ming-Yu Chen, Huei-Jean Huang, Hung-Hsueh Chou, Kuan-Gen Huang, Ting-Chang Chang, Tzu-Hao Wang, Chyong-Huey Lai
OBJECTIVES: Synchronous endometrial and ovarian carcinomas (SEOCs) present gynecologic oncologists with a challenging diagnostic puzzle: discriminating between double primary cancers and single primary cancer with metastasis. We aimed to determine the clonal relationship between simultaneously diagnosed endometrial and ovarian carcinomas. METHODS: Fourteen pairs of SEOCs of endometrioid type and two pairs of SEOCs with disparate histologic types (control for dual primary tumors) were subjected to massively parallel sequencing (MPS) and molecular inversion probe microarrays...
October 2016: Gynecologic Oncology
Luca Roncati, Antonio Manenti, Teresa Pusiol, Francesco Piscioli, Giuseppe Barbolini, Antonio Maiorana
OBJECTIVE: Aromatization is the biochemical process in which aromatase catalyzes the conversion of testosterone into estradiol, the fundamental pathway for the synthesis of estrogens. When enhanced, it can lead to hyperestrogenism, a well-known risk factor for gynecological cancers. METHODS: The surgical specimens, coming from 2 postmenopausal women with hyperestrogenism on pap smear and bioptic diagnosis of endometrial endometrioid carcinoma, were fixed in 10% neutral buffered formalin, paraffin embedded, and then submitted for routine hematoxylin/eosin staining and immunohistochemical characterization for antiestrogen, antiprogesterone, antitesterone, anti-MLH1, anti-PMS2, anti-MSH2, and anti-MSH6...
October 2016: International Journal of Gynecological Cancer
Carla Bartosch, Ana S Pires-Luís, Catarina Meireles, Manuela Baptista, Alfredo Gouveia, Carla Pinto, Kristen M Shannon, Carmen Jerónimo, Manuel R Teixeira, José M Lopes, Esther Oliva
Women with Lynch syndrome (LS) have a high risk of developing endometrial carcinoma (EC) and, less frequently, ovarian carcinoma. As EC not uncommonly is the first malignancy, prophylactic hysterectomy (PH) has been increasingly implemented. In this study, we report the clinicopathologic features of a series of 70 LS patients who underwent either PH (n=39) or nonprophylactic hysterectomy (NPH) (n=31) at 3 tertiary referral centers. Among the 39 patients with PH, 2 had endometrial tumors seen grossly, whereas 37 showed no macroscopic lesions...
September 2016: American Journal of Surgical Pathology
R Bi, X Y Tu, Y X Xiao, B E Shan, H Y Wang, X Cai, X Y Zhou, W T Yang
OBJECTIVE: To study the expression of mismatch repair protein in a series of endometrial carcinomas and its correlation with clinicopathologic features. METHODS: The clinical data of 150 consecutive cases of endometrial carcinoma were collected during the period from December, 2014 to August, 2015 in Fudan University Cancer Center. Morphologic features including tumor infiltrating lymphocytes (TIL), peritumoral lymphocytes and tumor heterogeneity were reviewed. Immunohistochemistry for expression of mismatch repair proteins was performed...
May 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Katie K Crean, Eric C Huang, Edwin A Alvarez
INTRODUCTION: Synchronous gynecologic primary cancers are uncommon. When present, the most frequent malignancies consist of endometrial and ovarian carcinomas. Here we report an exceedingly rare case of concurrent uterine adenocarcinoma and leiomyosarcoma. CASE PRESENTATION: A 60 year-old female presented with four years of postmenopausal bleeding. An endometrial sampling showed grade 2 endometrioid adenocarcinoma. She proceeded with hysterectomy that contained an anterior endometrial mass and a posterior myometrial mass...
2016: International Journal of Surgery Case Reports
M A Narin, A Karalok, D Basaran, I Ureyen, O Turkmen, T Turan, G Tulunay
OBJECTIVE: To determine the effect of synchronous endometrial endometrioid cancer (SEEC) on the prognosis of patients with Stage 1 endometrioid ovarian cancer (EOC). STUDY DESIGN: Clinicopathological data of cases with Stage 1 EOC from January 2000 to November 2013 were retrieved from the computerized database of Etlik Zubeyde Hanim Women's Health and Research Hospital. Of the 31 patients included in the study, 15 patients had primary synchronous endometrial and ovarian cancer (SEOC) (Group 1) and 16 patients had EOC alone (Group 2)...
May 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Benito Chiofalo, Jacopo Di Giuseppe, Lara Alessandrini, Tiziana Perin, Giorgio Giorda, Vincenzo Canzonieri, Francesco Sopracordevole
BACKGROUND: Three primary synchronous cancers in the female genital tract are extremely rare. In the literature, only four studies have described three different invasive gynecologic cancers of epithelial origin identified simultaneously in the same patient. CASE PRESENTATION: This is the first case in the literature that reports on triple primary ovarian, endometrial and endocervical cancers in a 38-year-old woman with a history of previously treated malignant disease (acute lymphatic leukemia)...
June 2016: Pathology, Research and Practice
Douglas I Lin, Jonathan L Hecht
Endometrial cancer is associated with Lynch syndrome in 2% to 6% of cases. Adequate screening may prevent of a second cancer and incident cancers in family members via risk-reducing strategies. The goal of the study was to evaluate the detection rate of Lynch syndrome via a targeted screening approach. In 2009, we incorporated targeted Lynch syndrome screening via immunohistochemistry for MLH1, PMS2, MSH2, and MSH6, followed by MLH1 promoter hypermethylation, in select cases of endometrial carcinoma. Criteria for patient selection included (1) all patients <50 years; (2) patients of any age with tumors showing features of microsatellite instability (lower uterine segment-centered tumors, hard to classify carcinomas, increased peritumoral or tumor infiltrating lymphocytes and cases with synchronous ovarian carcinomas); (3) clinician's request based on family or personal history; and (4) ad hoc retrospective testing based on the established criteria on patients discovered on follow-up visits...
June 2016: International Journal of Surgical Pathology
Don S Dizon, Michael J Birrer
For women with early-stage ovarian or endometrial cancers, prognosis is very good, with overall survival for both sites between 80% and 90%. This stands in stark contrast to metastatic disease (advanced stage), where the overall survival is less than 15%. We have long recognized that subtypes of disease also inform these statistics, with high-grade serous carcinomas conferring a far worse prognosis compared with others, including low-grade serous or endometrioid tumors. Yet even with our present understanding, a not uncommon finding is the diagnosis of women with carcinoma at both the ovary and the uterus (a situation that occurs in up to 10% of patients), raising the question of synchronous primaries or of metastatic disease...
June 2016: Journal of the National Cancer Institute
Michael S Anglesio, Yi Kan Wang, Madlen Maassen, Hugo M Horlings, Ali Bashashati, Janine Senz, Robertson Mackenzie, Diljot S Grewal, Hector Li-Chang, Anthony N Karnezis, Brandon S Sheffield, Melissa K McConechy, Friedrich Kommoss, Florin A Taran, Annette Staebler, Sohrab P Shah, Diethelm Wallwiener, Sara Brucker, C Blake Gilks, Stefan Kommoss, David G Huntsman
Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave as independent primary tumors rather than a single advanced-stage carcinoma. We used 18 SEOs to investigate the ancestral relationship between the endometrial and ovarian components. Based on both targeted and exome sequencing, 17 of 18 patient cases of simultaneous cancer of the endometrium and ovary from our series showed evidence of a clonal relationship, ie, primary tumor and metastasis...
June 2016: Journal of the National Cancer Institute
Anne M Schultheis, Charlotte K Y Ng, Maria R De Filippo, Salvatore Piscuoglio, Gabriel S Macedo, Sonia Gatius, Belen Perez Mies, Robert A Soslow, Raymond S Lim, Agnes Viale, Kety H Huberman, Jose C Palacios, Jorge S Reis-Filho, Xavier Matias-Guiu, Britta Weigelt
Synchronous early-stage endometrioid endometrial carcinomas (EECs) and endometrioid ovarian carcinomas (EOCs) are associated with a favorable prognosis and have been suggested to represent independent primary tumors rather than metastatic disease. We subjected sporadic synchronous EECs/EOCs from five patients to whole-exome massively parallel sequencing, which revealed that the EEC and EOC of each case displayed strikingly similar repertoires of somatic mutations and gene copy number alterations. Despite the presence of mutations restricted to the EEC or EOC in each case, we observed that the mutational processes that shaped their respective genomes were consistent...
June 2016: Journal of the National Cancer Institute
Peter F Rambau, Máire A Duggan, Prafull Ghatage, Khadija Warfa, Helen Steed, Renee Perrier, Linda E Kelemen, Martin Köbel
AIMS: Lynch syndrome screening in ovarian carcinoma is controversial. The aim of this study was to assess the frequency of deficient mismatch repair (dMMR) protein in a retrospective cohort enriched for non-high-grade serous carcinomas and its association with outcome within histological types. METHODS AND RESULTS: Tissue microarrays representing 612 ovarian carcinomas were tested for mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6) by immunohistochemistry...
August 2016: Histopathology
Elena Pereira, Olga Camacho-Vanegas, Sanya Anand, Robert Sebra, Sandra Catalina Camacho, Leopold Garnar-Wortzel, Navya Nair, Erin Moshier, Melissa Wooten, Andrew Uzilov, Rong Chen, Monica Prasad-Hayes, Konstantin Zakashansky, Ann Marie Beddoe, Eric Schadt, Peter Dottino, John A Martignetti
BACKGROUND: High-grade serous ovarian and endometrial cancers are the most lethal female reproductive tract malignancies worldwide. In part, failure to treat these two aggressive cancers successfully centers on the fact that while the majority of patients are diagnosed based on current surveillance strategies as having a complete clinical response to their primary therapy, nearly half will develop disease recurrence within 18 months and the majority will die from disease recurrence within 5 years...
2015: PloS One
Hossein Sadidi, Narges Izadi-Mood, Soheila Sarmadi, Fariba Yarandi, Soheila Amini-Moghaddam, Fatemeh Esfahani, Mohammad Sadidi
BACKGROUND: The coexistence primary cancers of the endometrium and ovary are relatively uncommon. The purpose of this study was to characterize patients diagnosed primary synchronous endometrial and ovarian cancer (SEOC), endometrial cancer (EC) with ovarian metastasis, and ovarian cancer (OC) with endometrial metastasis and compare clinicopathologic variables and prognosis. MATERIALS AND METHODS: All the patients with diagnosis of both endometrium and OC, who hospitalized between 2002 and 2012 in an academic center affiliated to Tehran University of Medical Sciences, were evaluated with respect to different clinicopathologic variables, follow-up times, and outcomes...
August 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Sina Seifi Noferesti, Md Mahmodul Hasan Sohel, Michael Hoelker, Dessie Salilew-Wondim, Ernst Tholen, Christian Looft, Franca Rings, Christiane Neuhoff, Karl Schellander, Dawit Tesfaye
BACKGROUND: Despite its role in increasing the number of offspring during the lifetime of an individual animal, controlled ovarian hyperstimulation (COH) may have detrimental effects on oocyte development, embryo quality and endometrial receptivity. Circulating miRNAs in bio-fluids have been shown to be associated with various pathological conditions including cancers. Here we aimed to investigate the effect of COH on the level of extracellular miRNAs in bovine follicular fluid and blood plasma and elucidate their mode of circulation and potential molecular mechanisms to be affected in the reproductive tract...
2015: Journal of Ovarian Research
Tugan Bese, Veysel Sal, Ilker Kahramanoglu, Nedim Tokgozoglu, Fuat Demirkiran, Hasan Turan, Sennur Ilvan, Macit Arvas
OBJECTIVE: The purpose of this study was to evaluate the clinicopathological characteristics and survival outcomes of women with simultaneous endometrial and ovarian carcinomas having the same histopathologic type. MATERIALS AND METHODS: A review of medical records from 1997 to 2015 identified 72 patients with simultaneous carcinomas of the endometrium and ovary with the same histopathologic type. Patients with synchronous primary cancers of endometrium and ovary (SCEOs) were compared with patients with primary endometrial cancer with ovarian metastasis (ECOM)...
February 2016: International Journal of Gynecological Cancer
Hamdullah Sozen, Dogan Vatansever, Ahmet Cem Iyibozkurt, Samet Topuz, Mehmet Ozsurmeli, Yavuz Salihoglu, Burcu Guzelbey, Sinan Berkman
AIM: The aim of the study was to describe clinicopathologic characteristics, survival outcomes and the factors associated with recurrence in patients diagnosed with synchronous primary endometrial and epithelial ovarian cancers. MATERIAL AND METHODS: In this retrospective study, 50 patients who were diagnosed with synchronous primary endometrial and epithelial ovarian cancers and underwent surgery between 1998 and 2010 were reviewed. RESULTS: In our study, the median age at the time of diagnosis was 53 years (range 28-79)...
November 2015: Journal of Obstetrics and Gynaecology Research
Patrícia Isidro Amaral, Abel Silva, Abílio Lacerda, Carlos Barros
Ovarian cancer is the leading cause of death from gynaecological malignancy in developed countries. Synchronous endometrioid endometrial and ovarian cancer in patients appears with different clinical characteristics compared to patients with isolated endometrial cancer. A 34-year-old woman with lower abdominal pain of 1 year duration presented at the emergency department. On gynaecological examination, she had a left and midline pelvic mass. A transvaginal ultrasound showed it to be a complex hypervascularised mass, with cystic and solid components on left adnexal region...
2015: BMJ Case Reports
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