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https://www.readbyqxmd.com/read/27755538/circulating-apolipoprotein-e-concentration-and-cardiovascular-disease-risk-meta-analysis-of-results-from-three-studies
#1
Reecha Sofat, Jackie A Cooper, Meena Kumari, Juan P Casas, Jacqueline P Mitchell, Jayshree Acharya, Simon Thom, Alun D Hughes, Steve E Humphries, Aroon D Hingorani
BACKGROUND: The association of APOE genotype with circulating apolipoprotein E (ApoE) concentration and cardiovascular disease (CVD) risk is well established. However, the relationship of circulating ApoE concentration and CVD has received little attention. METHODS AND FINDINGS: To address this, we measured circulating ApoE concentration in 9,587 individuals (with 1,413 CVD events) from three studies with incident CVD events: two population-based studies, the English Longitudinal Study of Ageing (ELSA) and the men-only Northwick Park Heart Study II (NPHSII), and a nested sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)...
October 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27342221/selecting-instruments-for-mendelian-randomization-in-the-wake-of-genome-wide-association-studies
#2
Daniel I Swerdlow, Karoline B Kuchenbaecker, Sonia Shah, Reecha Sofat, Michael V Holmes, Jon White, Jennifer S Mindell, Mika Kivimaki, Eric J Brunner, John C Whittaker, Juan P Casas, Aroon D Hingorani
Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that instrument these exposures. The approach is gaining popularity-our systematic review reveals a greater than 10-fold increase in MR studies published between 2004 and 2015. When the MR paradigm was first proposed, few biomarker- or exposure-related genetic variants were known, most having been identified by candidate gene studies. However, genome-wide association studies (GWAS) are now providing a rich source of potential instruments for MR analysis...
June 24, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/26781229/plasma-urate-concentration-and-risk-of-coronary-heart-disease-a-mendelian-randomisation-analysis
#3
Jon White, Reecha Sofat, Gibran Hemani, Tina Shah, Jorgen Engmann, Caroline Dale, Sonia Shah, Felix A Kruger, Claudia Giambartolomei, Daniel I Swerdlow, Tom Palmer, Stela McLachlan, Claudia Langenberg, Delilah Zabaneh, Ruth Lovering, Alana Cavadino, Barbara Jefferis, Chris Finan, Andrew Wong, Antoinette Amuzu, Ken Ong, Tom R Gaunt, Helen Warren, Teri-Louise Davies, Fotios Drenos, Jackie Cooper, Shah Ebrahim, Debbie A Lawlor, Philippa J Talmud, Steve E Humphries, Christine Power, Elina Hypponen, Marcus Richards, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Yoav Ben-Shlomo, Ian N Day, Peter Whincup, Richard Morris, Mark W J Strachan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Vincent Plagnol, John C Whittaker, George Davey Smith, Frank Dudbridge, Juan P Casas, Michael V Holmes, Aroon D Hingorani
BACKGROUND: Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis. METHODS: We first did a fixed-effects meta-analysis of the observational association of plasma urate and risk of coronary heart disease...
April 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/25262344/hmg-coenzyme-a-reductase-inhibition-type-2-diabetes-and-bodyweight-evidence-from-genetic-analysis-and-randomised-trials
#4
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen E L Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul C D Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene C W Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi G J Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John J V McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, W M Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS: We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes...
January 24, 2015: Lancet
https://www.readbyqxmd.com/read/24563418/novel-genetic-approach-to-investigate-the-role-of-plasma-secretory-phospholipase-a2-spla2-v-isoenzyme-in-coronary-heart-disease-modified-mendelian-randomization-analysis-using-pla2g5-expression-levels
#5
Michael V Holmes, Holly J Exeter, Lasse Folkersen, Christopher P Nelson, Montse Guardiola, Jackie A Cooper, Reecha Sofat, S Matthijs Boekholdt, Kay-Tee Khaw, Ka-Wah Li, Andrew J P Smith, Ferdinand Van't Hooft, Per Eriksson, Anders Franco-Cereceda, Folkert W Asselbergs, Jolanda M A Boer, N Charlotte Onland-Moret, Marten Hofker, Jeanette Erdmann, Mika Kivimaki, Meena Kumari, Alex P Reiner, Brendan J Keating, Steve E Humphries, Aroon D Hingorani, Ziad Mallat, Nilesh J Samani, Philippa J Talmud
BACKGROUND: Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. Although observational studies show a strong association between elevated sPLA2 activity and CHD, no assay to measure sPLA2-V levels exists, and the only evidence linking the sPLA2-V isoform to atherosclerosis progression comes from animal studies. In the absence of an assay that directly quantifies sPLA2-V levels, we used PLA2G5 mRNA levels in a novel, modified Mendelian randomization approach to investigate the hypothesized causal role of sPLA2-V in coronary heart disease (CHD) pathogenesis...
April 2014: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/24474739/mendelian-randomization-of-blood-lipids-for-coronary-heart-disease
#6
Michael V Holmes, Folkert W Asselbergs, Tom M Palmer, Fotios Drenos, Matthew B Lanktree, Christopher P Nelson, Caroline E Dale, Sandosh Padmanabhan, Chris Finan, Daniel I Swerdlow, Vinicius Tragante, Erik P A van Iperen, Suthesh Sivapalaratnam, Sonia Shah, Clara C Elbers, Tina Shah, Jorgen Engmann, Claudia Giambartolomei, Jon White, Delilah Zabaneh, Reecha Sofat, Stela McLachlan, Pieter A Doevendans, Anthony J Balmforth, Alistair S Hall, Kari E North, Berta Almoguera, Ron C Hoogeveen, Mary Cushman, Myriam Fornage, Sanjay R Patel, Susan Redline, David S Siscovick, Michael Y Tsai, Konrad J Karczewski, Marten H Hofker, W Monique Verschuren, Michiel L Bots, Yvonne T van der Schouw, Olle Melander, Anna F Dominiczak, Richard Morris, Yoav Ben-Shlomo, Jackie Price, Meena Kumari, Jens Baumert, Annette Peters, Barbara Thorand, Wolfgang Koenig, Tom R Gaunt, Steve E Humphries, Robert Clarke, Hugh Watkins, Martin Farrall, James G Wilson, Stephen S Rich, Paul I W de Bakker, Leslie A Lange, George Davey Smith, Alex P Reiner, Philippa J Talmud, Mika Kivimäki, Debbie A Lawlor, Frank Dudbridge, Nilesh J Samani, Brendan J Keating, Aroon D Hingorani, Juan P Casas
AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P < 2 × 10(-6)); and the second a restricted score, filtered to remove any SNPs also associated with either of the other two lipid traits at P ≤ 0...
March 1, 2015: European Heart Journal
https://www.readbyqxmd.com/read/23977022/population-genomics-of-cardiometabolic-traits-design-of-the-university-college-london-london-school-of-hygiene-and-tropical-medicine-edinburgh-bristol-ucleb-consortium
#7
Tina Shah, Jorgen Engmann, Caroline Dale, Sonia Shah, Jon White, Claudia Giambartolomei, Stela McLachlan, Delilah Zabaneh, Alana Cavadino, Chris Finan, Andrew Wong, Antoinette Amuzu, Ken Ong, Tom Gaunt, Michael V Holmes, Helen Warren, Daniel I Swerdlow, Teri-Louise Davies, Fotios Drenos, Jackie Cooper, Reecha Sofat, Mark Caulfield, Shah Ebrahim, Debbie A Lawlor, Philippa J Talmud, Steve E Humphries, Christine Power, Elina Hypponen, Marcus Richards, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Claudia Langenberg, Yoav Ben-Shlomo, Ian N Day, Peter Whincup, Richard Morris, Mark W J Strachan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Vincent Plagnol, Frank Dudbridge, John C Whittaker, Juan P Casas, Aroon D Hingorani
Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies...
2013: PloS One
https://www.readbyqxmd.com/read/23733552/genetic-risk-factors-for-intracranial-aneurysms-a-meta-analysis-in-more-than-116-000-individuals
#8
REVIEW
Varinder S Alg, Reecha Sofat, Henry Houlden, David J Werring
OBJECTIVE: There is an urgent need to identify risk factors for sporadic intracranial aneurysm (IA) development and rupture. A genetic component has long been recognized, but firm conclusions have been elusive given the generally small sample sizes and lack of replication. Genome-wide association studies have overcome some limitations, but the number of robust genetic risk factors for IA remains uncertain. METHODS: We conducted a comprehensive systematic review and meta-analysis of all genetic association studies (including genome-wide association studies) of sporadic IA, conducted according to Strengthening the Reporting of Genetic Association Studies and Human Genome Epidemiology Network guidelines...
June 4, 2013: Neurology
https://www.readbyqxmd.com/read/23505291/gene-centric-analysis-identifies-variants-associated-with-interleukin-6-levels-and-shared-pathways-with-other-inflammation-markers
#9
Tina Shah, Delilah Zabaneh, Tom Gaunt, Daniel I Swerdlow, Sonia Shah, Philippa J Talmud, Ian N Day, John Whittaker, Michael V Holmes, Reecha Sofat, Steve E Humphries, Mika Kivimaki, Meena Kumari, Aroon D Hingorani, Juan P Casas
BACKGROUND- Inflammatory cytokine interleukin-6 (IL-6), a possible risk factor for coronary heart disease, has an estimated heritability of >60%, but to date few genetic variants influencing IL-6 levels are known. METHODS AND RESULTS- We used the ITMAT-Broad-Care (IBC) HumanCVD disease BeadChip in the Whitehall II study (N=4911) and British Women's Heart and Health Study (N=3445) to identify single-nucleotide polymorphisms associated with circulating IL-6 levels. Twenty-two single-nucleotide polymorphisms from 7 loci (IL6R/TDRD10, HLA-DRB1, BUD13, SEZ6L, IL1RN, TRIB3, and ABO) were associated with IL-6 (P<10(-5)), although none were associated with the IL6 gene itself...
April 2013: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/23376722/distribution-and-determinants-of-circulating-complement-factor-h-concentration-determined-by-a-high-throughput-immunonephelometric-assay
#10
Reecha Sofat, P Patrizia Mangione, J Ruth Gallimore, Svetlana Hakobyan, Timothy R Hughes, Tina Shah, Tim Goodship, Francesco D'Aiuto, Claudia Langenberg, Nick Wareham, B Paul Morgan, Mark B Pepys, Aroon D Hingorani
BACKGROUND: Research on complement factor H (fH) in human disease is hampered by lack of an assay suitable for use in large-scale epidemiological studies. We describe the development and validation of a high throughput nephelometric assay for fH. METHODS: Reagents from a commercial radial immunodiffusion (RID) assay (The Binding Site) were adapted for use on the Siemens BNII high throughput nephelometric instrument. The assay was calibrated with a highly purified human fH preparation with rigorously determined concentration, and assay performance was comprehensively evaluated using samples from healthy human volunteers, with the commercial RID assay as a comparator...
April 30, 2013: Journal of Immunological Methods
https://www.readbyqxmd.com/read/23351090/comparative-efficacy-and-tolerability-of-anti-epileptic-drugs-for-refractory-focal-epilepsy-systematic-review-and-network-meta-analysis-reveals-the-need-for-long-term-comparator-trials
#11
REVIEW
Pritesh N Bodalia, Anthony M Grosso, Reecha Sofat, Raymond J Macallister, Liam Smeeth, Soraya Dhillon, Juan-Pablo Casas, David Wonderling, Aroon D Hingorani
AIMS: To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy. METHODS: We searched Cochrane Central Register of Controlled Trials (Cochrane Library 2009, issue 2) including Epilepsy Group's specialized register, MEDLINE (1950 to March 2009), EMBASE (1980 to March 2009), and Current Contents Connect (1998 to March 2009) to conduct a systematic review of published studies, developed a treatment network and undertook a network meta-analysis...
November 2013: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/23098369/arms2-increases-the-risk-of-early-and-late-age-related-macular-degeneration-in-the-european-eye-study
#12
MULTICENTER STUDY
Usha Chakravarthy, Gareth J McKay, Paulus T V M de Jong, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Johannes R Vingerling, Jesus Vioque, Ian S Young, Reecha Sofat, Aroon D Hingorani, Astrid E Fletcher
OBJECTIVE: To study associations between severity stages of early and late age-related macular degeneration (AMD) and genetic variations in age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) and to investigate potential interactions between smoking and ARMS2. DESIGN: Population-based, cross-sectional European Eye Study in 7 countries in Europe. PARTICIPANTS: Four thousand seven hundred fifty participants, 65 years of age and older, recruited through random sampling...
February 2013: Ophthalmology
https://www.readbyqxmd.com/read/22977227/influence-of-common-genetic-variation-on-blood-lipid-levels-cardiovascular-risk-and-coronary-events-in-two-british-prospective-cohort-studies
#13
Sonia Shah, Juan P Casas, Tom R Gaunt, Jackie Cooper, Fotios Drenos, Delilah Zabaneh, Daniel I Swerdlow, Tina Shah, Reecha Sofat, Jutta Palmen, Meena Kumari, Mika Kivimaki, Shah Ebrahim, George Davey Smith, Debbie A Lawlor, Philippa J Talmud, John Whittaker, Ian N M Day, Aroon D Hingorani, Steve E Humphries
AIMS: The aim of this study was to quantify the collective effect of common lipid-associated single nucleotide polymorphisms (SNPs) on blood lipid levels, cardiovascular risk, use of lipid-lowering medication, and risk of coronary heart disease (CHD) events. METHODS AND RESULTS: Analysis was performed in two prospective cohorts: Whitehall II (WHII; N = 5059) and the British Women's Heart and Health Study (BWHHS; N = 3414). For each participant, scores were calculated based on the cumulative effect of multiple genetic variants influencing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)...
April 2013: European Heart Journal
https://www.readbyqxmd.com/read/22766581/is-it-important-to-measure-or-reduce-c-reactive-protein-in-people-at-risk-of-cardiovascular-disease
#14
Aroon D Hingorani, Reecha Sofat, Richard W Morris, Peter Whincup, Gordon D Lowe, Jennifer Mindell, Naveed Sattar, Juan P Casas, Tina Shah
No abstract text is available yet for this article.
September 2012: European Heart Journal
https://www.readbyqxmd.com/read/22253316/complement-factor-h-genetic-variant-and-age-related-macular-degeneration-effect-size-modifiers-and-relationship-to-disease-subtype
#15
Reecha Sofat, Juan P Casas, Andrew R Webster, Alan C Bird, Samantha S Mann, John R W Yates, Anthony T Moore, Tiina Sepp, Valentina Cipriani, Catey Bunce, Jane C Khan, Humma Shahid, Anand Swaroop, Gonçalo Abecasis, Kari E H Branham, Sepideh Zareparsi, Arthur A Bergen, Caroline C W Klaver, Dominique C Baas, Kang Zhang, Yuhong Chen, Daniel Gibbs, Bernhard H F Weber, Claudia N Keilhauer, Lars G Fritsche, Andrew Lotery, Angela J Cree, Helen L Griffiths, Shomi S Bhattacharya, Li L Chen, Sharon A Jenkins, Tunde Peto, Mark Lathrop, Thierry Leveillard, Michael B Gorin, Daniel E Weeks, Maria Carolina Ortube, Robert E Ferrell, Johanna Jakobsdottir, Yvette P Conley, Mati Rahu, Johan H Seland, Gisele Soubrane, Fotis Topouzis, Jesus Vioque, Laura Tomazzoli, Ian Young, John Whittaker, Usha Chakravarthy, Paulus T V M de Jong, Liam Smeeth, Astrid Fletcher, Aroon D Hingorani
BACKGROUND: Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking. METHODS: To precisely quantify the association of the single nucleotide polymorphism (SNP rs1061170, 'Y402H') with risk of AMD among studies with differing study designs, participant ancestry and AMD grade and to investigate effect modification by smoking, we report two unpublished genetic association studies (n = 2759) combined with data from 24 published studies (26 studies, 26,494 individuals, including 14,174 cases of AMD) of European ancestry, 10 of which provided individual-level data used to test gene-smoking interaction; and 16 published studies from non-European ancestry...
February 2012: International Journal of Epidemiology
https://www.readbyqxmd.com/read/22246267/could-nice-guidance-on-the-choice-of-blood-pressure-lowering-drugs-be-simplified
#16
Reecha Sofat, Juan P Casas, Anthony M Grosso, Brian N C Prichard, Liam Smeeth, Raymond MacAllister, Aroon D Hingorani
No abstract text is available yet for this article.
January 13, 2012: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/21882290/evidence-of-association-of-apoe-with-age-related-macular-degeneration-a-pooled-analysis-of-15-studies
#17
Gareth J McKay, Chris C Patterson, Usha Chakravarthy, Shilpa Dasari, Caroline C Klaver, Johannes R Vingerling, Lintje Ho, Paulus T V M de Jong, Astrid E Fletcher, Ian S Young, Johan H Seland, Mati Rahu, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Jesus Vioque, Aroon D Hingorani, Reecha Sofat, Michael Dean, Julie Sawitzke, Johanna M Seddon, Inga Peter, Andrew R Webster, Anthony T Moore, John R W Yates, Valentina Cipriani, Lars G Fritsche, Bernhard H F Weber, Claudia N Keilhauer, Andrew J Lotery, Sarah Ennis, Michael L Klein, Peter J Francis, Dwight Stambolian, Anton Orlin, Michael B Gorin, Daniel E Weeks, Chia-Ling Kuo, Anand Swaroop, Mohammad Othman, Atsuhiro Kanda, Wei Chen, Goncalo R Abecasis, Alan F Wright, Caroline Hayward, Paul N Baird, Robyn H Guymer, John Attia, Ammarin Thakkinstian, Giuliana Silvestri
Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160) demonstrating associations between late AMD and APOε4 (odds ratio [OR] = 0.72 per haplotype; confidence interval [CI]: 0...
December 2011: Human Mutation
https://www.readbyqxmd.com/read/21804106/comparative-analysis-of-genome-wide-association-studies-signals-for-lipids-diabetes-and-coronary-heart-disease-cardiovascular-biomarker-genetics-collaboration
#18
COMPARATIVE STUDY
Aspasia Angelakopoulou, Tina Shah, Reecha Sofat, Sonia Shah, Diane J Berry, Jackie Cooper, Jutta Palmen, Ioanna Tzoulaki, Andrew Wong, Barbara J Jefferis, Nikolas Maniatis, Fotios Drenos, Bruna Gigante, Rebecca Hardy, Ross C Laxton, Karin Leander, Anna Motterle, Iain A Simpson, Liam Smeeth, Andy Thomson, Claudio Verzilli, Diana Kuh, Helen Ireland, John Deanfield, Mark Caulfield, Chris Wallace, Nilesh Samani, Patricia B Munroe, Mark Lathrop, F Gerry R Fowkes, Michael Marmot, Peter H Whincup, John C Whittaker, Ulf de Faire, Mika Kivimaki, Meena Kumari, Elina Hypponen, Chris Power, Steve E Humphries, Philippa J Talmud, Jackie Price, Richard W Morris, Shu Ye, Juan P Casas, Aroon D Hingorani
AIMS: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-derived lipid-associated SNPs with other risk factors and CHD events. METHODS AND RESULTS: Using two case-control studies, three cross-sectional, and seven prospective studies with up to 25 000 individuals and 5794 CHD events we evaluated associations of 34 genome-wide-association study-identified SNPs with CHD risk and 16 CHD-associated risk factors or biomarkers...
February 2012: European Heart Journal
https://www.readbyqxmd.com/read/21803414/effect-modification-by-population-dietary-folate-on-the-association-between-mthfr-genotype-homocysteine-and-stroke-risk-a-meta-analysis-of-genetic-studies-and-randomised-trials
#19
MULTICENTER STUDY
Michael V Holmes, Paul Newcombe, Jaroslav A Hubacek, Reecha Sofat, Sally L Ricketts, Jackie Cooper, Monique M B Breteler, Leonelo E Bautista, Pankaj Sharma, John C Whittaker, Liam Smeeth, F Gerald R Fowkes, Ale Algra, Veronika Shmeleva, Zoltan Szolnoki, Mark Roest, Michael Linnebank, Jeppe Zacho, Michael A Nalls, Andrew B Singleton, Luigi Ferrucci, John Hardy, Bradford B Worrall, Stephen S Rich, Mar Matarin, Paul E Norman, Leon Flicker, Osvaldo P Almeida, Frank M van Bockxmeer, Hiroshi Shimokata, Kay-Tee Khaw, Nicholas J Wareham, Martin Bobak, Jonathan A C Sterne, George Davey Smith, Philippa J Talmud, Cornelia van Duijn, Steve E Humphries, Jackie F Price, Shah Ebrahim, Debbie A Lawlor, Graeme J Hankey, James F Meschia, Manjinder S Sandhu, Aroon D Hingorani, Juan P Casas
BACKGROUND: The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview showed that the effects were greatest in regions with low dietary folate consumption, but differentiation between the effect of folate and small-study bias was difficult. A meta-analysis of randomised trials of homocysteine-lowering interventions showed no reduction in coronary heart disease events or stroke, but the trials were generally set in populations with high folate consumption...
August 13, 2011: Lancet
https://www.readbyqxmd.com/read/21534939/genetic-variants-associated-with-von-willebrand-factor-levels-in-healthy-men-and-women-identified-using-the-humancvd-beadchip
#20
Delilah Zabaneh, Tom R Gaunt, Meena Kumari, Fotios Drenos, Sonia Shah, Diane Berry, Chris Power, Elina Hypponen, Tina Shah, Jutta Palmen, Jacky Pallas, Philippa J Talmud, Juan Pablo Casas, Reecha Sofat, Gordon Lowe, Ann Rumley, Richard W Morris, Peter H Whincup, Santiago Rodriguez, Shah Ebrahim, Michael G Marmot, George Davey Smith, Debbie A Lawlor, Mika Kivimaki, John Whittaker, Aroon D Hingorani, Ian N Day, Steve E Humphries
We have used the gene-centric Illumina HumanCVD BeadChip to identify common genetic determinants of Von Willebrand factor (vWF) levels in healthy men and women. The Whitehall II (WHII) study (n= 5592) and the British Women's Heart and Health Study (BWHHS) (n= 3445) were genotyped using the HumanCVD BeadChip. Replication was conducted in the British Regional Heart Study (n= 3897) and 1958 Birth Cohort (n= 5048). We identified 48 single nucleotide polymorphisms (SNPs) in four genes/regions associated with vWF at P < 10(-4) ...
July 2011: Annals of Human Genetics
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