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JOURNAL ARTICLE
Theresa A McDonagh, Marco Metra, Marianna Adamo, Roy S Gardner, Andreas Baumbach, Michael Böhm, Haran Burri, Javed Butler, Jelena Čelutkienė, Ovidiu Chioncel, John G F Cleland, Andrew J S Coats, Maria G Crespo-Leiro, Dimitrios Farmakis, Martine Gilard, Stephane Heymans, Arno W Hoes, Tiny Jaarsma, Ewa A Jankowska, Mitja Lainscak, Carolyn S P Lam, Alexander R Lyon, John J V McMurray, Alexandre Mebazaa, Richard Mindham, Claudio Muneretto, Massimo Francesco Piepoli, Susanna Price, Giuseppe M C Rosano, Frank Ruschitzka, Anne Kathrine Skibelund
Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator) (Netherlands), P. Christian Schulze (CPG Review Coordinator) (Germany), Magdy Abdelhamid (Egypt), Victor Aboyans (France), Stamatis Adamopoulos (Greece), Stefan D. Anker (Germany), Elena Arbelo (Spain), Riccardo Asteggiano (Italy), Johann Bauersachs (Germany), Antoni Bayes-Genis (Spain), Michael A. Borger (Germany), Werner Budts (Belgium), Maja Cikes (Croatia), Kevin Damman (Netherlands), Victoria Delgado (Netherlands), Paul Dendale (Belgium), Polychronis Dilaveris (Greece), Heinz Drexel (Austria), Justin Ezekowitz (Canada), Volkmar Falk (Germany), Laurent Fauchier (France), Gerasimos Filippatos (Greece), Alan Fraser (United Kingdom), Norbert Frey (Germany), Chris P...
January 2022: European Journal of Heart Failure
#22
JOURNAL ARTICLE
Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E Grobbee, Dipak Kotecha, Stefan D Anker, Tomasz Dyszynski, Benoît Tyl, Spiros Denaxas, R Thomas Lumbers, Harry Hemingway
BACKGROUND: Primary prevention strategies for heart failure(HF) have had limited success, possibly due to a wide range of underlying risk factors(RFs). Systematic evaluations of the prognostic burden and preventive potential across this wide range of risk factors are lacking. OBJECTIVE: To estimate evidence, prevalence and co-occurrence for primary prevention and impact on prognosis of RFs for incident HF. METHODS: We systematically reviewed trials and observational evidence of primary HF prevention across 92 putative aetiologic RFs for HF identified from US and European clinical practice guidelines...
December 30, 2021: European Journal of Heart Failure
#23
JOURNAL ARTICLE
Andrew J S Coats, Stephane Heymans, Dimitrios Farmakis, Stefan D Anker, Johannes Backs, Johann Bauersachs, Rudolf A de Boer, Jelena Čelutkienė, John G F Cleland, Dobromir Dobrev, Isabelle C van Gelder, Stephan von Haehling, Gerhard Hindricks, Ewa Jankowska, Dipak Kotecha, Linda W van Laake, Mitja Lainscak, Lars H Lund, Ida Gjervold Lunde, Alexander R Lyon, Aristomenis Manouras, Davor Miličić, Christian Mueller, Marija Polovina, Piotr Ponikowski, Giuseppe Rosano, Petar M Seferović, Carsten Tschöpe, Rolf Wachter, Frank Ruschitzka
No abstract text is available yet for this article.
December 7, 2021: European Heart Journal
#24
Rachel Studer, Claudio Sartini, Kiliana Suzart-Woischnik, Rumjhum Agrawal, Harshul Natani, Simrat K Gill, Sara Bruce Wirta, Folkert W Asselbergs, Richard Dobson, Spiros Denaxas, Dipak Kotecha
BACKGROUND: Transparent and robust real-world evidence sources are increasingly important for global health, including cardiovascular (CV) diseases. We aimed to identify global real-world data (RWD) sources for heart failure (HF), acute coronary syndrome (ACS), and atrial fibrillation (AF). METHODS: We conducted a systematic review of publications with RWD pertaining to HF, ACS, and AF (2010-2018), generating a list of unique data sources. Metadata were extracted based on the source type (e...
2022: Cardiology
#25
JOURNAL ARTICLE
Andreas Karwath, Karina V Bunting, Simrat K Gill, Otilia Tica, Samantha Pendleton, Furqan Aziz, Andrey D Barsky, Saisakul Chernbumroong, Jinming Duan, Alastair R Mobley, Victor Roth Cardoso, Luke Slater, John A Williams, Emma-Jane Bruce, Xiaoxia Wang, Marcus D Flather, Andrew J S Coats, Georgios V Gkoutos, Dipak Kotecha
BACKGROUND: Mortality remains unacceptably high in patients with heart failure and reduced left ventricular ejection fraction (LVEF) despite advances in therapeutics. We hypothesised that a novel artificial intelligence approach could better assess multiple and higher-dimension interactions of comorbidities, and define clusters of β-blocker efficacy in patients with sinus rhythm and atrial fibrillation. METHODS: Neural network-based variational autoencoders and hierarchical clustering were applied to pooled individual patient data from nine double-blind, randomised, placebo-controlled trials of β blockers...
October 16, 2021: Lancet
#26
JOURNAL ARTICLE
Rebecca Persson, Todd Sponholtz, Catherine Vasilakis-Scaramozza, Katrina Wilcox Hagberg, Tim Williams, Dipak Kotecha, Puja Myles, Susan S Jick
Background: Validation studies of the Clinical Practice Research Datalink (CPRD) Aurum database in the UK are critical for making decisions about its suitability and validity for research purposes. Objective: To examine data source agreement of myocardial infarction (MI) diagnoses recorded in CPRD Aurum compared with linked Hospital Episode Statistics (HES) data. This comparison provides information on CPRD Aurum data correctness (accuracy, validity) and completeness (presence, missingness)...
2021: Clinical Epidemiology
#27
JOURNAL ARTICLE
Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio, Israel Moshe Barbash, José A Barrabés, Giuseppe Boriani, Frieder Braunschweig, Michele Brignole, Haran Burri, Andrew J S Coats, Jean-Claude Deharo, Victoria Delgado, Gerhard-Paul Diller, Carsten W Israel, Andre Keren, Reinoud E Knops, Dipak Kotecha, Christophe Leclercq, Béla Merkely, Christoph Starck, Ingela Thylén, José Maria Tolosana
No abstract text is available yet for this article.
September 14, 2021: European Heart Journal
#28
JOURNAL ARTICLE
Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio, Israel Moshe Barbash, José A Barrabés, Giuseppe Boriani, Frieder Braunschweig, Michele Brignole, Haran Burri, Andrew J S Coats, Jean-Claude Deharo, Victoria Delgado, Gerhard-Paul Diller, Carsten W Israel, Andre Keren, Reinoud E Knops, Dipak Kotecha, Christophe Leclercq, Béla Merkely, Christoph Starck, Ingela Thylén, José Maria Tolosana, Francisco Leyva, Cecilia Linde, Magdy Abdelhamid, Victor Aboyans, Elena Arbelo, Riccardo Asteggiano, Gonzalo Barón-Esquivias, Johann Bauersachs, Mauro Biffi, Ulrika Birgersdotter-Green, Maria Grazia Bongiorni, Michael A Borger, Jelena Čelutkienė, Maja Cikes, Jean-Claude Daubert, Inga Drossart, Kenneth Ellenbogen, Perry M Elliott, Larissa Fabritz, Volkmar Falk, Laurent Fauchier, Francisco Fernández-Avilés, Dan Foldager, Fredrik Gadler, Pastora Gallego Garcia De Vinuesa, Bulent Gorenek, Jose M Guerra, Kristina Hermann Haugaa, Jeroen Hendriks, Thomas Kahan, Hugo A Katus, Aleksandra Konradi, Konstantinos C Koskinas, Hannah Law, Basil S Lewis, Nicholas John Linker, Maja-Lisa Løchen, Joost Lumens, Julia Mascherbauer, Wilfried Mullens, Klaudia Vivien Nagy, Eva Prescott, Pekka Raatikainen, Amina Rakisheva, Tobias Reichlin, Renato Pietro Ricci, Evgeny Shlyakhto, Marta Sitges, Miguel Sousa-Uva, Richard Sutton, Piotr Suwalski, Jesper Hastrup Svendsen, Rhian M Touyz, Isabelle C Van Gelder, Kevin Vernooy, Johannes Waltenberger, Zachary Whinnett, Klaus K Witte
No abstract text is available yet for this article.
January 4, 2022: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#29
JOURNAL ARTICLE
Ana-Catarina Pinho-Gomes, Luis Azevedo, Emma Copland, Dexter Canoy, Milad Nazarzadeh, Rema Ramakrishnan, Eivind Berge, Johan Sundström, Dipak Kotecha, Mark Woodward, Koon Teo, Barry R Davis, John Chalmers, Carl J Pepine, Kazem Rahimi
BACKGROUND: Randomised evidence on the efficacy of blood pressure (BP)-lowering treatment to reduce cardiovascular risk in patients with atrial fibrillation (AF) is limited. Therefore, this study aimed to compare the effects of BP-lowering drugs in patients with and without AF at baseline. METHODS AND FINDINGS: The study was based on the resource provided by the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC), in which individual participant data (IPD) were extracted from trials with over 1,000 patient-years of follow-up in each arm, and that had randomly assigned patients to different classes of BP-lowering drugs, BP-lowering drugs versus placebo, or more versus less intensive BP-lowering regimens...
June 2021: PLoS Medicine
#30
LETTER
Dipak Kotecha
No abstract text is available yet for this article.
April 27, 2021: JAMA
#31
JOURNAL ARTICLE
Amitava Banerjee, Suliang Chen, Ghazaleh Fatemifar, Mohamad Zeina, R Thomas Lumbers, Johanna Mielke, Simrat Gill, Dipak Kotecha, Daniel F Freitag, Spiros Denaxas, Harry Hemingway
BACKGROUND: Machine learning (ML) is increasingly used in research for subtype definition and risk prediction, particularly in cardiovascular diseases. No existing ML models are routinely used for cardiovascular disease management, and their phase of clinical utility is unknown, partly due to a lack of clear criteria. We evaluated ML for subtype definition and risk prediction in heart failure (HF), acute coronary syndromes (ACS) and atrial fibrillation (AF). METHODS: For ML studies of subtype definition and risk prediction, we conducted a systematic review in HF, ACS and AF, using PubMed, MEDLINE and Web of Science from January 2000 until December 2019...
April 6, 2021: BMC Medicine
#32
JOURNAL ARTICLE
Karina V Bunting, Simrat K Gill, Alice Sitch, Samir Mehta, Kieran O'Connor, Gregory Yh Lip, Paulus Kirchhof, Victoria Y Strauss, Kazem Rahimi, A John Camm, Mary Stanbury, Michael Griffith, Jonathan N Townend, Georgios V Gkoutos, Andreas Karwath, Richard P Steeds, Dipak Kotecha
OBJECTIVE: To improve the echocardiographic assessment of heart failure in patients with atrial fibrillation (AF) by comparing conventional averaging of consecutive beats with an index-beat approach, whereby measurements are taken after two cycles with similar R-R interval. METHODS: Transthoracic echocardiography was performed using a standardised and blinded protocol in patients enrolled in the RATE-AF (RAte control Therapy Evaluation in permanent Atrial Fibrillation) randomised trial...
June 2021: Heart
#33
JOURNAL ARTICLE
Karina V Bunting, Mary Stanbury, Otilia Tica, Dipak Kotecha
No abstract text is available yet for this article.
February 28, 2021: European Heart Journal
#34
JOURNAL ARTICLE
Larissa Fabritz, Harry J G M Crijns, Eduard Guasch, Andreas Goette, Karl Georg Häusler, Dipak Kotecha, Thorsten Lewalter, Christian Meyer, Tatjana S Potpara, Michiel Rienstra, Renate B Schnabel, Stephan Willems, Guenter Breithardt, A John Camm, Anthony Chan, Winnie Chua, Mirko de Melis, Christina Dimopoulou, Dobromir Dobrev, Christina Easter, Lars Eckardt, Doreen Haase, Stephane Hatem, Jeff S Healey, Jordi Heijman, Stefan H Hohnloser, Thomas Huebner, Bushra Saeed Ilyas, Aaron Isaacs, Ingo Kutschka, Christophe Leclercq, Gregory Y H Lip, Elena Andreassi Marinelli, Jose L Merino, Lluís Mont, Michael Nabauer, Jonas Oldgren, Helmut Pürerfellner, Ursula Ravens, Irina Savelieva, Moritz F Sinner, Alice Sitch, Rüdiger Smolnik, Jan Steffel, Kenneth Stein, Monika Stoll, Emma Svennberg, Dierk Thomas, Isabelle C Van Gelder, Burcu Vardar, Reza Wakili, Mattias Wieloch, Stef Zeemering, Paul D Ziegler, Hein Heidbuchel, Gerhard Hindricks, Ulrich Schotten, Paulus Kirchhof
AIMS: The risk of developing atrial fibrillation (AF) and its complications continues to increase, despite good progress in preventing AF-related strokes. METHODS AND RESULTS: This article summarizes the outcomes of the 7th Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) held in Lisbon in March 2019. Sixty-five international AF specialists met to present new data and find consensus on pressing issues in AF prevention, management and future research to improve care for patients with AF and prevent AF-related complications...
January 12, 2021: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#35
RANDOMIZED CONTROLLED TRIAL
Dipak Kotecha, Karina V Bunting, Simrat K Gill, Samir Mehta, Mary Stanbury, Jacqueline C Jones, Sandra Haynes, Melanie J Calvert, Jonathan J Deeks, Richard P Steeds, Victoria Y Strauss, Kazem Rahimi, A John Camm, Michael Griffith, Gregory Y H Lip, Jonathan N Townend, Paulus Kirchhof
IMPORTANCE: There is little evidence to support selection of heart rate control therapy in patients with permanent atrial fibrillation, in particular those with coexisting heart failure. OBJECTIVE: To compare low-dose digoxin with bisoprolol (a β-blocker). DESIGN, SETTING, AND PARTICIPANTS: Randomized, open-label, blinded end-point clinical trial including 160 patients aged 60 years or older with permanent atrial fibrillation (defined as no plan to restore sinus rhythm) and dyspnea classified as New York Heart Association class II or higher...
December 22, 2020: JAMA
#36
REVIEW
Karina V Bunting, Kieran O'Connor, Richard P Steeds, Dipak Kotecha
The validity and reproducibility of systolic function assessment in patients with atrial fibrillation (AF) using cardiac magnetic resonance, echocardiography, nuclear imaging and computed tomography is unknown. A prospectively-registered systematic review was performed, including 24 published studies with patients in AF at the time of imaging and reporting validity or reproducibility data on left ventricular systolic parameters (PROSPERO: CRD42018091674). Data extraction and risk of bias were performed by 2 investigators independently and synthesized qualitatively...
January 15, 2021: American Journal of Cardiology
#37
JOURNAL ARTICLE
Giulia Renda, Ladislav Pecen, Giuseppe Patti, Fabrizio Ricci, Dipak Kotecha, Jolanta M Siller-Matula, Renate B Schnabel, Rolf Wachter, Jean-Marc Sellal, Miklos Rohla, Markus Lucerna, Kurt Huber, Freek W A Verheugt, Jose Luis Zamorano, Bernd Brüggenjürgen, Harald Darius, Mattias Duytschaever, Jean-Yves Le Heuzey, Richard J Schilling, Paulus Kirchhof, Raffaele De Caterina
The management of patients with atrial fibrillation (AF) has rapidly changed with increasing use of non-vitamin K antagonist oral anticoagulants (NOACs) and changes in the use of rhythm control therapy. The prevention of thromboembolic events European Registry in Atrial Fibrillation Prolongation Registry (PREFER Prolongation) enrolled consecutive patients with AF on NOACs between 2014 and 2016 in a multicentre, prospective, observational study with one-year follow-up, focusing on the time of introduction of NOACs...
September 21, 2020: Internal and Emergency Medicine
#38
JOURNAL ARTICLE
Jacqueline Jones, Mary Stanbury, Sandra Haynes, Karina V Bunting, Trudie Lobban, A John Camm, Melanie J Calvert, Dipak Kotecha
AIMS: To establish the extent and impact of symptoms in patients with atrial fibrillation (AF), the importance of different aspects of quality of life (QoL), and how we should assess wellbeing. METHODS: Focus groups of patients with symptomatic permanent AF in a trial of heart rate control; the RATE-AF trial randomised 160 patients aged ≥60 years with permanent AF and at least NYHA class II dyspnoea to either digoxin or beta-blockers. Patient and public representatives led the focus groups and performed all data acquisition and analysis, using thematic approaches to interpret patient views about QoL and its measurement...
August 28, 2020: Cardiology
#39
JOURNAL ARTICLE
Karina V Bunting, Isabelle C Van Gelder, Dipak Kotecha
No abstract text is available yet for this article.
June 1, 2020: European Heart Journal
#40
JOURNAL ARTICLE
Oliver J Ziff, Monica Samra, James P Howard, Daniel I Bromage, Frank Ruschitzka, Darrel P Francis, Dipak Kotecha
BACKGROUND: Beta-blockers are widely used for many cardiovascular conditions; however, their efficacy in contemporary clinical practice remains uncertain. METHODS: We performed a prospectively designed, umbrella review of meta-analyses of randomised controlled trials (RCTs) investigating the evidence of beta-blockers in the contemporary management of coronary artery disease (CAD), heart failure (HF), patients undergoing surgery or hypertension (registration: PROSPERO CRD42016038375)...
May 5, 2020: BMC Medicine
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