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JOURNAL ARTICLE
Dominik Linz, Jason G Andrade, Elena Arbelo, Giuseppe Boriani, Guenter Breithardt, A John Camm, Valeria Caso, Jens Cosedis Nielsen, Mirko De Melis, Tom De Potter, Wolfgang Dichtl, Søren Zoega Diederichsen, Dobromir Dobrev, Nicolas Doll, David Duncker, Elke Dworatzek, Lars Eckardt, Christoph Eisert, Larissa Fabritz, Michal Farkowski, David Filgueiras-Rama, Andreas Goette, Eduard Guasch, Guido Hack, Stéphane Hatem, Karl Georg Haeusler, Jeff S Healey, Hein Heidbuechel, Ziad Hijazi, Lucas H Hofmeister, Leif Hove-Madsen, Thomas Huebner, Stefan Kääb, Dipak Kotecha, Katarzyna Malaczynska-Rajpold, José Luis Merino, Andreas Metzner, Lluís Mont, Ghulam Andre Ng, Michael Oeff, Abdul Shokor Parwani, Helmut Puererfellner, Ursula Ravens, Michiel Rienstra, Prashanthan Sanders, Daniel Scherr, Renate Schnabel, Ulrich Schotten, Christian Sohns, Gerhard Steinbeck, Daniel Steven, Tobias Toennis, Stylianos Tzeis, Isabelle C van Gelder, Roderick H van Leerdam, Kevin Vernooy, Manish Wadhwa, Reza Wakili, Stephan Willems, Henning Witt, Stef Zeemering, Paulus Kirchhof
AIMS: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). METHODS AND RESULTS: Eighty-three international experts met in Münster for 2 days in September 2023...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#2
JOURNAL ARTICLE
Jeannette Majert, Milad Nazarzadeh, Rema Ramakrishnan, Zeinab Bidel, Deborah Hedgecott, Abel Perez-Crespillo, Wendy Turpie, Naseem Akhtar, Moira Allison, Shishir Rao, Bernard Gudgin, Melanie McAuley, Christine A'Court, Laurent Billot, Dipak Kotecha, John Potter, Kazem Rahimi
BACKGROUND: Older patients with multimorbidity and polypharmacy have been under-represented in clinical trials. We aimed to assess the effect of different intensities of antihypertensive treatment on changes in blood pressure, major safety outcomes, and patient-reported outcomes in this population. METHODS: ATEMPT was a decentralised, two-armed, parallel-group, open-label randomised controlled pilot trial conducted in the Thames Valley area, South East England. Individuals aged 65 years or older with multimorbidity (three or more chronic conditions) or polypharmacy (five or more types of medications) and a systolic blood pressure of 115-165 mm Hg were eligible for inclusion...
February 8, 2024: The Lancet. Healthy longevity
#3
JOURNAL ARTICLE
Claire Baudier, Françoise Fougerousse, Folkert W Asselbergs, Mickael Guedj, Michel Komajda, Dipak Kotecha, R Thomas Lumbers, Amand F Schmidt, Benoît Tyl
BACKGROUND: The effects of α and ß adrenergic receptor modulation on the risk of developing heart failure (HF) remains uncertain due to a lack of randomized controlled trials. This study aimed to estimate the effects of α and ß adrenergic receptors modulation on the risk of HF and to provide proof of principle for genetic target validation studies in HF. METHODS: Genetic variants within the cis regions encoding the adrenergic receptors α1A, α2B, ß1, and ß2 associated with blood pressure in a 757,601-participant genome-wide association study (GWAS) were selected as instruments to perform a drug target Mendelian randomization study...
2023: Frontiers in Cardiovascular Medicine
#4
JOURNAL ARTICLE
Madeleine Perrett, Nisha Gohil, Otilia Tica, Karina V Bunting, Dipak Kotecha
BACKGROUND: Intravenous beta-blockers are commonly used to manage patients with acute atrial fibrillation (AF) and atrial flutter (AFl), but the choice of specific agent is often not evidence-based. METHODS: A prospectively-registered systematic review and meta-analysis of randomised trials (PROSPERO: CRD42020204772) to compare the safety and efficacy of intravenous beta-blockers against alternative pharmacological agents. RESULTS: Twelve trials comparing beta-blockers with diltiazem, digoxin, verapamil, anti-arrhythmic drugs and placebo were included, with variable risk of bias and 1152 participants...
September 1, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#5
REVIEW
Paul Andrews, Kurt Anseeuw, Dipak Kotecha, Frédéric Lapostolle, Ruben Thanacoody
There are currently no universally accepted guidelines for the management of digoxin toxicity. In the absence of clinical practice guidelines, a set of consensus recommendations for management of digoxin toxicity in the clinical setting were developed through a modified Delphi approach. The recommendations highlight the importance of early recognition of signs of potentially life-threatening toxicity that requires immediate treatment with digoxin-specific antibodies. The consensus identifies a straightforward approach to dosing immune antibody fragments according to the presence or absence of signs of life-threatening toxicity...
December 1, 2023: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
#6
JOURNAL ARTICLE
Ravi Vijapurapu, Ashwin Roy, Polyvios Demetriades, Adrian Warfield, Derralynn A Hughes, James Moon, Peter Woolfson, Joseph de Bono, Tarekegn Geberhiwot, Dipak Kotecha, Richard Paul Steeds
INTRODUCTION: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by enzyme deficiency, leading to glycosphingolipid accumulation. Cardiac accumulation triggers local tissue injury, electrical instability and arrhythmia. Bradyarrhythmia and atrial fibrillation (AF) incidence are reported in up to 16% and 13%, respectively. OBJECTIVE: We conducted a systematic review evaluating AF burden and bradycardia requiring permanent pacemaker (PPM) implantation and report any predictive risk factors identified...
July 2023: Open Heart
#7
JOURNAL ARTICLE
Folkert W Asselbergs, Dipak Kotecha
No abstract text is available yet for this article.
July 6, 2023: European Heart Journal
#8
JOURNAL ARTICLE
Piotr Szymanski, Franz Weidinger, Isabelle Lordereau-Richard, Anders Himmelmann, Marcello Arca, Jose Chaves, Charles Lee, Carla Jonker, Dipak Kotecha, James O'Kelly, Kelly Plueschke, Andrzej Ryś, Andrej Segec, Lars Wallentin, Rogier Veltrop, Stefan James
Real world data (RWD) usually refers to healthcare information that is routinely collected in electronic healthcare records (EHR), hospital and pharmacy records, patient and disease registries, and health insurance databases. The collection and analysis of this vast amount of data is an important complement to that obtained from conventional randomised controlled trials (RCT). RWD has been used for healthcare quality improvements, to conduct clinical trials, to support drug and device development, and to inform medical guidelines...
February 6, 2023: European Heart Journal. Quality of Care & Clinical Outcomes
#9
JOURNAL ARTICLE
Xiaoxia Wang, Alastair R Mobley, Otilia Tica, Kelvin Okoth, Rebecca E Ghosh, Puja Myles, Tim Williams, Sandra Haynes, Krishnarajah Nirantharakumar, David Shukla, Dipak Kotecha
AIMS: Improving the efficiency of clinical trials is key to their continued importance in directing evidence-based patient care. Digital innovations, in particular the use of electronic healthcare records (EHRs), allow for large-scale screening and follow up of participants. However, it is critical these developments are accompanied by robust and transparent methods that can support high-quality and high clinical value research. METHODS AND RESULTS: The DaRe2THINK trial includes a series of novel processes, including nationwide pseudonymized pre screening of the primary-care EHR across England, digital enrolment, remote e-consent, and 'no-visit' follow up by linking all primary- and secondary-care health data with patient-reported outcomes...
September 2022: European heart journal. Digital health
#10
REVIEW
Helena Lee, Daisy Wilson, Karina V Bunting, Dipak Kotecha, Thomas Jackson
The geroscience hypothesis proposes biological hallmarks of ageing are modifiable. Increasing evidence supports targeting these hallmarks with therapeutics could prevent and ameliorate age-related conditions - collectively termed "geroprotector drugs". Cellular senescence is a hallmark with considerable potential to be modified with geroprotector drugs. Senotherapeutics are drugs that target cellular senescence for therapeutic benefit. Repurposing commonly used medications with secondary geroprotector properties is a strategy of interest to promote incorporation of geroprotector drugs into clinical practice...
January 19, 2023: Ageing Research Reviews
#11
JOURNAL ARTICLE
Simrat K Gill, Andreas Karwath, Hae-Won Uh, Victor Roth Cardoso, Zhujie Gu, Andrey Barsky, Luke Slater, Animesh Acharjee, Jinming Duan, Lorenzo Dall'Olio, Said El Bouhaddani, Saisakul Chernbumroong, Mary Stanbury, Sandra Haynes, Folkert W Asselbergs, Diederick E Grobbee, Marinus J C Eijkemans, Georgios V Gkoutos, Dipak Kotecha
Artificial intelligence (AI) is increasingly being utilized in healthcare. This article provides clinicians and researchers with a step-wise foundation for high-value AI that can be applied to a variety of different data modalities. The aim is to improve the transparency and application of AI methods, with the potential to benefit patients in routine cardiovascular care. Following a clear research hypothesis, an AI-based workflow begins with data selection and pre-processing prior to analysis, with the type of data (structured, semi-structured, or unstructured) determining what type of pre-processing steps and machine-learning algorithms are required...
March 1, 2023: European Heart Journal
#12
JOURNAL ARTICLE
Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazmierski, Susanne Løgstrup, R Thomas Lumbers, Thomas F Lüscher, Paul McGreavy, Ileana L Piña, Lothar Roessig, Carl Steinbeisser, Mats Sundgren, Benoît Tyl, Ghislaine van Thiel, Kees van Bochove, Panos E Vardas, Tiago Villanueva, Marilena Vrana, Wim Weber, Franz Weidinger, Stephan Windecker, Angela Wood, Diederick E Grobbee
Big data is central to new developments in global clinical science aiming to improve the lives of patients. Technological advances have led to the routine use of structured electronic healthcare records with the potential to address key gaps in clinical evidence. The covid-19 pandemic has demonstrated the potential of big data and related analytics, but also important pitfalls. Verification, validation, and data privacy, as well as the social mandate to undertake research are key challenges. The European Society of Cardiology and the BigData@Heart consortium have brought together a range of international stakeholders, including patient representatives, clinicians, scientists, regulators, journal editors and industry...
August 29, 2022: BMJ: British Medical Journal
#13
JOURNAL ARTICLE
Dipak Kotecha, Adam D DeVore, Folkert W Asselbergs
No abstract text is available yet for this article.
January 1, 2023: European Heart Journal
#14
JOURNAL ARTICLE
Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazmierski, Susanne Løgstrup, R Thomas Lumbers, Thomas F Lüscher, Paul McGreavy, Ileana L Piña, Lothar Roessig, Carl Steinbeisser, Mats Sundgren, Benoît Tyl, Ghislaine van Thiel, Kees van Bochove, Panos E Vardas, Tiago Villanueva, Marilena Vrana, Wim Weber, Franz Weidinger, Stephan Windecker, Angela Wood, Diederick E Grobbee
Big data is central to new developments in global clinical science aiming to improve the lives of patients. Technological advances have led to the routine use of structured electronic healthcare records with the potential to address key gaps in clinical evidence. The covid-19 pandemic has demonstrated the potential of big data and related analytics, but also important pitfalls. Verification, validation, and data privacy, as well as the social mandate to undertake research are key challenges. The European Society of Cardiology and the BigData@Heart consortium have brought together a range of international stakeholders, including patient representatives, clinicians, scientists, regulators, journal editors and industry...
October 7, 2022: European Heart Journal
#15
JOURNAL ARTICLE
Otilia Țica, Ovidiu Țica, Karina V Bunting, Joseph deBono, Georgios V Gkoutos, Mircea I Popescu, Dipak Kotecha
BACKGROUND: The prevalence of combined heart failure (HF) and atrial fibrillation (AF) is rising, and these patients suffer from high rates of mortality. This study aims to provide robust data on factors associated with death, uniquely supported by post-mortem examination. METHODS: A retrospective cohort study of hospitalized adults with a clinical diagnosis of HF and AF at a tertiary centre in Romania between 2014 and 2017. A standardized post-mortem examination was performed where death occurred within 24 h of admission, when the cause of death was not clear or by physician request...
October 5, 2022: BMC Medicine
#16
REVIEW
Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazmierski, Susanne Løgstrup, R Thomas Lumbers, Thomas F Lüscher, Paul McGreavy, Ileana L Piña, Lothar Roessig, Carl Steinbeisser, Mats Sundgren, Benoît Tyl, Ghislaine van Thiel, Kees van Bochove, Panos E Vardas, Tiago Villanueva, Marilena Vrana, Wim Weber, Franz Weidinger, Stephan Windecker, Angela Wood, Diederick E Grobbee
Big data is important to new developments in global clinical science that aim to improve the lives of patients. Technological advances have led to the regular use of structured electronic health-care records with the potential to address key deficits in clinical evidence that could improve patient care. The COVID-19 pandemic has shown this potential in big data and related analytics but has also revealed important limitations. Data verification, data validation, data privacy, and a mandate from the public to conduct research are important challenges to effective use of routine health-care data...
August 26, 2022: The Lancet. Digital health
#17
JOURNAL ARTICLE
Sigrun Halvorsen, Julinda Mehilli, Salvatore Cassese, Trygve S Hall, Magdy Abdelhamid, Emanuele Barbato, Stefan De Hert, Ingrid de Laval, Tobias Geisler, Lynne Hinterbuchner, Borja Ibanez, Radosław Lenarczyk, Ulrich R Mansmann, Paul McGreavy, Christian Mueller, Claudio Muneretto, Alexander Niessner, Tatjana S Potpara, Arsen Ristić, L Elif Sade, Henrik Schirmer, Stefanie Schüpke, Henrik Sillesen, Helge Skulstad, Lucia Torracca, Oktay Tutarel, Peter Van Der Meer, Wojtek Wojakowski, Kai Zacharowski
No abstract text is available yet for this article.
October 14, 2022: European Heart Journal
#18
JOURNAL ARTICLE
Renate B Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M Buckley, A John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Søren Zöga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stéphane N Hatem, Karl Georg Haeusler, Jeff S Healey, Hein Heidbuchel, Gerhard Hindricks, F D Richard Hobbs, Thomas Hübner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y H Lip, Maja Lisa Løchen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L Merino, Ralf Meyer, Lluıs Mont, Michael C Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S Potpara, George Psaroudakis, Helmut Pürerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F Sinner, Rüdiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C van Gelder, Burcu Vardar, Elena Palà, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, André Ziegler, Matthias Daniel Zink, Paulus Kirchhof
AIMS: Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. METHODS AND RESULTS: This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021...
July 27, 2022: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#19
JOURNAL ARTICLE
Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio, Israel Moshe Barbash, José A Barrabés, Giuseppe Boriani, Frieder Braunschweig, Michele Brignole, Haran Burri, Andrew J S Coats, Jean-Claude Deharo, Victoria Delgado, Gerhard-Paul Diller, Carsten W Israel, Andre Keren, Reinoud E Knops, Dipak Kotecha, Christophe Leclercq, Béla Merkely, Christoph Starck, Ingela Thylén, José Maria Tolosana
No abstract text is available yet for this article.
July 2022: Giornale Italiano di Cardiologia
#20
Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio, Israel Moshe Barbash, José A Barrabés, Giuseppe Boriani, Frieder Braunschweig, Michele Brignole, Haran Burri, Andrew J S Coats, Jean-Claude Deharo, Victoria Delgado, Gerhard-Paul Diller, Carsten W Israel, Andre Keren, Reinoud E Knops, Dipak Kotecha, Christophe Leclercq, Béla Merkely, Christoph Starck, Ingela Thylén, José María Tolosana
No abstract text is available yet for this article.
May 2022: Revista Española de Cardiología
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