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https://www.readbyqxmd.com/read/27855811/heart-failure-with-preserved-ejection%C3%A2-fraction-and%C3%A2-atrial-fibrillation-vicious-twins
#1
REVIEW
Dipak Kotecha, Carolyn S P Lam, Dirk J Van Veldhuisen, Isabelle C Van Gelder, Adriaan A Voors, Michiel Rienstra
Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are age-related conditions that are increasing in prevalence, commonly coexist, and share clinical features. This review provides a practical update on the epidemiology, pathophysiology, diagnosis, and management of patients with concomitant HFpEF and AF. Epidemiological studies highlight the close and complex links between HFpEF and AF, the shared risk factors, the high AF occurrence in the natural history of HFpEF, and the independent contribution of each condition to poor outcomes...
November 15, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27802324/patient-reported-outcomes-for-quality-of-life-assessment-in-atrial-fibrillation-a-systematic-review-of-measurement-properties
#2
Dipak Kotecha, Amar Ahmed, Melanie Calvert, Mauro Lencioni, Caroline B Terwee, Deirdre A Lane
BACKGROUND: Atrial fibrillation is a large and growing burden across all types of healthcare. Both incidence and prevalence are expected to double in the next 20 years, with huge impact on hospital admissions, costs and patient quality of life. Patient wellbeing determines the management strategy for atrial fibrillation, including the use of rhythm control therapy and the clinical success of heart rate control. Hence, evaluation of quality of life is an emerging and important part of the assessment of patients with atrial fibrillation...
2016: PloS One
https://www.readbyqxmd.com/read/27663299/2016-esc-guidelines-for-the-management-of-atrial-fibrillation-developed-in-collaboration-with-eacts-the-task-force-for-the-management-of-atrial-fibrillation-of-the-european-society-of-cardiology-esc-developed-with-the-special-contribution-of-the-european-heart
#3
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas, Stefan Agewall, John Camm, Gonzalo Baron Esquivias, Werner Budts, Scipione Carerj, Filip Casselman, Antonio Coca, Raffaele De Caterina, Spiridon Deftereos, Dobromir Dobrev, José M Ferro, Gerasimos Filippatos, Donna Fitzsimons, Bulent Gorenek, Maxine Guenoun, Stefan H Hohnloser, Philippe Kolh, Gregory Y H Lip, Athanasios Manolis, John McMurray, Piotr Ponikowski, Raphael Rosenhek, Frank Ruschitzka, Irina Savelieva, Sanjay Sharma, Piotr Suwalski, Juan Luis Tamargo, Clare J Taylor, Isabelle C Van Gelder, Adriaan A Voors, Stephan Windecker, Jose Luis Zamorano, Katja Zeppenfeld
No abstract text is available yet for this article.
September 23, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27609819/echocardiographic-structure-and-function-in-hypertensive-disorders-of-pregnancy-a-systematic-review
#4
James S Castleman, Ramesh Ganapathy, Fatima Taki, Gregory Y H Lip, Richard P Steeds, Dipak Kotecha
BACKGROUND: Echocardiography is commonly used to direct the management of hypertensive disorders in medical patients, but its application in pregnancy is unclear. Our objective was to define the use of echocardiography in pregnancies complicated by gestational hypertension (GH) and preeclampsia. METHODS AND RESULTS: We performed a systematic review of articles using an electronic search of databases from inception to March 2015, prospectively registered with PROSPERO (CRD42015015700)...
September 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27586233/magnesium-for-atrial-fibrillation-myth-or-magic
#5
EDITORIAL
Dipak Kotecha
No abstract text is available yet for this article.
September 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27567465/2016-esc-guidelines-for-the-management-of-atrial-fibrillation-developed-in-collaboration-with-eacts-the-task-force-for-the-management-of-atrial-fibrillation-of-the-european-society-of-cardiology-esc-developed-with-the-special-contribution-of-the-european-heart
#6
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas
No abstract text is available yet for this article.
August 27, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27567408/2016-esc-guidelines-for-the-management-of-atrial-fibrillation-developed-in-collaboration-with-eacts-the-task-force-for-the-management-of-atrial-fibrillation-of-the-european-society-of-cardiology-esc-developed-with-the-special-contribution-of-the-european-heart
#7
Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas
No abstract text is available yet for this article.
August 27, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27156593/digoxin-the-good-and-the-bad
#8
REVIEW
Oliver J Ziff, Dipak Kotecha
After 230 years of use, digitalis remains an important and useful therapy for patients with atrial fibrillation, heart failure, and the 30-50 % of patients with both conditions. Although the combination of positive inotropic activity with negative chronotropic effects has been shown to reduce hospital admissions in heart failure, there is a distinct lack of robust trial data, particularly in patients with atrial fibrillation. We recently performed a comprehensive meta-analysis of all digoxin studies and demonstrated a neutral effect on mortality...
October 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27098105/effect-of-age-and-sex-on-efficacy-and-tolerability-of-%C3%AE-blockers-in-patients-with-heart-failure-with-reduced-ejection-fraction-individual-patient-data-meta-analysis
#9
REVIEW
Dipak Kotecha, Luis Manzano, Henry Krum, Giuseppe Rosano, Jane Holmes, Douglas G Altman, Peter D Collins, Milton Packer, John Wikstrand, Andrew J S Coats, John G F Cleland, Paulus Kirchhof, Thomas G von Lueder, Alan S Rigby, Bert Andersson, Gregory Y H Lip, Dirk J van Veldhuisen, Marcelo C Shibata, Hans Wedel, Michael Böhm, Marcus D Flather
OBJECTIVES: To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo controlled randomised trials. DESIGN: Prospectively designed meta-analysis of individual patient data from patients aged 40-85 in sinus rhythm at baseline, with left ventricular ejection fraction <0.45. PARTICIPANTS: 13,833 patients from 11 trials; median age 64; 24% women...
April 20, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27087520/letter-conflicting-and-unresolved-issue-of-the-prognostic-value-of-atrial-fibrillation-for-chronic-heart-failure-patients-response
#10
Dipak Kotecha
No abstract text is available yet for this article.
July 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26950607/in-memoriam-henry-krum-1958-2015
#11
Thomas G von Lueder, Ingrid Hopper, Dipak Kotecha, Dan Atar
No abstract text is available yet for this article.
2016: Cardiology
https://www.readbyqxmd.com/read/26829930/comorbidities-in-heart-failure-are-there-gender-differences
#12
REVIEW
Ingrid Hopper, Dipak Kotecha, Ken Lee Chin, Robert J Mentz, Thomas G von Lueder
Compared to men, women with heart failure (HF) are often older, smoke less, and have more preserved ejection fraction (EF) and hypertensive HF rather than HF of ischemic etiology. Gender-stratified outcomes on comorbidities data in HF are scarce. Women have traditionally been underrepresented in HF trials. Although data suggest that overall prognosis may be better in women, they experience lower quality of life with greater functional impairment from HF compared to men. Gender differences have been reported for comorbid diabetes, chronic obstructive pulmonary disease, renal dysfunction, anemia, and depression and may explain gender disparity in outcomes...
February 2016: Current Heart Failure Reports
https://www.readbyqxmd.com/read/26580351/atrial-fibrillation-and-heart-failure-due-to-reduced-versus-preserved-ejection-fraction-a-systematic-review-and-meta-analysis-of-death-and-adverse-outcomes
#13
REVIEW
Dipak Kotecha, Rajiv Chudasama, Deirdre A Lane, Paulus Kirchhof, Gregory Y H Lip
BACKGROUND: Atrial fibrillation (AF) and heart failure frequently coexist, commonly resulting in serious adverse events. With both conditions increasing in prevalence and justified concerns about treatment efficacy, it is vital to understand how the type of heart failure impacts on prognosis. METHODS: We performed a systematic review of studies examining cardiovascular outcomes in AF patients with heart failure and reduced ejection fraction (AF-HFrEF) compared to those with preserved ejection fraction (AF-HFpEF)...
January 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26481149/a-roadmap-to-improve-the-quality-of-atrial-fibrillation-management-proceedings-from-the-fifth-atrial-fibrillation-network-european-heart-rhythm-association-consensus-conference
#14
REVIEW
Paulus Kirchhof, Günter Breithardt, Jeroen Bax, Gerlinde Benninger, Carina Blomstrom-Lundqvist, Giuseppe Boriani, Axel Brandes, Helen Brown, Martina Brueckmann, Hugh Calkins, Melanie Calvert, Vincent Christoffels, Harry Crijns, Dobromir Dobrev, Patrick Ellinor, Larissa Fabritz, Thomas Fetsch, S Ben Freedman, Andrea Gerth, Andreas Goette, Eduard Guasch, Guido Hack, Laurent Haegeli, Stephane Hatem, Karl Georg Haeusler, Hein Heidbüchel, Jutta Heinrich-Nols, Francoise Hidden-Lucet, Gerd Hindricks, Steen Juul-Möller, Stefan Kääb, Lukas Kappenberger, Stefanie Kespohl, Dipak Kotecha, Deirdre A Lane, Angelika Leute, Thorsten Lewalter, Ralf Meyer, Lluis Mont, Felix Münzel, Michael Nabauer, Jens C Nielsen, Michael Oeff, Jonas Oldgren, Ali Oto, Jonathan P Piccini, Art Pilmeyer, Tatjana Potpara, Ursula Ravens, Holger Reinecke, Thomas Rostock, Joerg Rustige, Irene Savelieva, Renate Schnabel, Ulrich Schotten, Lars Schwichtenberg, Moritz F Sinner, Gerhard Steinbeck, Monika Stoll, Luigi Tavazzi, Sakis Themistoclakis, Hung Fat Tse, Isabelle C Van Gelder, Panagiotis E Vardas, Timo Varpula, Alphons Vincent, David Werring, Stephan Willems, André Ziegler, Gregory Y H Lip, A John Camm
At least 30 million people worldwide carry a diagnosis of atrial fibrillation (AF), and many more suffer from undiagnosed, subclinical, or 'silent' AF. Atrial fibrillation-related cardiovascular mortality and morbidity, including cardiovascular deaths, heart failure, stroke, and hospitalizations, remain unacceptably high, even when evidence-based therapies such as anticoagulation and rate control are used. Furthermore, it is still necessary to define how best to prevent AF, largely due to a lack of clinical measures that would allow identification of treatable causes of AF in any given patient...
January 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26419625/atrial-fibrillation-in-heart-failure-what-should-we-do
#15
REVIEW
Dipak Kotecha, Jonathan P Piccini
Heart failure (HF) and atrial fibrillation (AF) are two conditions that are likely to dominate the next 50 years of cardiovascular (CV) care. Both are increasingly prevalent and associated with high morbidity, mortality, and healthcare cost. They are closely inter-related with similar risk factors and shared pathophysiology. Patients with concomitant HF and AF suffer from even worse symptoms and poorer prognosis, yet evidence-based evaluation and management of this group of patients is lacking. In this review, we evaluate the common mechanisms for the development of AF in HF patients and vice versa, focusing on the evidence for potential treatment strategies...
December 7, 2015: European Heart Journal
https://www.readbyqxmd.com/read/26321114/safety-and-efficacy-of-digoxin-systematic-review-and-meta-analysis-of-observational-and-controlled-trial-data
#16
REVIEW
Oliver J Ziff, Deirdre A Lane, Monica Samra, Michael Griffith, Paulus Kirchhof, Gregory Y H Lip, Richard P Steeds, Jonathan Townend, Dipak Kotecha
OBJECTIVE: To clarify the impact of digoxin on death and clinical outcomes across all observational and randomised controlled trials, accounting for study designs and methods. DATA SOURCES AND STUDY SELECTION: Comprehensive literature search of Medline, Embase, the Cochrane Library, reference lists, and ongoing studies according to a prospectively registered design ( PROSPERO: CRD42014010783), including all studies published from 1960 to July 2014 that examined treatment with digoxin compared with control (placebo or no treatment)...
2015: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/26205373/residual-risk-of-stroke-and-death-in-anticoagulated-patients-according-to-the-type-of-atrial-fibrillation-amadeus-trial
#17
Keitaro Senoo, Gregory Y H Lip, Deirdre A Lane, Harry R Büller, Dipak Kotecha
BACKGROUND AND PURPOSE: Atrial fibrillation (AF) and heart failure frequently coexist and are associated with increased morbidity and mortality. We investigated the prognosis of anticoagulated patients with permanent AF and nonpermanent AF according to preexisting heart failure in the AMADEUS (Evaluating the Use of SR34006 Compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation) trial. METHODS: The primary outcome was a composite of cardiovascular death and stroke or systemic embolism, analyzed using a Cox proportional hazards model, adjusted for baseline age, sex, diabetes mellitus, hypertension, creatinine, and previous cardiovascular diseases...
September 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25746532/qualifying-the-use-of-common-cardiovascular-drugs-in-cardiology
#18
EDITORIAL
Dipak Kotecha, Thomas G von Lueder
No abstract text is available yet for this article.
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/25628305/increased-stroke-risk-in-atrial-fibrillation-patients-with-heart-failure-does-ejection-fraction-matter
#19
EDITORIAL
Dipak Kotecha, Amitava Banerjee, Gregory Y H Lip
No abstract text is available yet for this article.
March 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25193873/efficacy-of-%C3%AE-blockers-in-patients-with-heart-failure-plus-atrial-fibrillation-an-individual-patient-data-meta-analysis
#20
Dipak Kotecha, Jane Holmes, Henry Krum, Douglas G Altman, Luis Manzano, John G F Cleland, Gregory Y H Lip, Andrew J S Coats, Bert Andersson, Paulus Kirchhof, Thomas G von Lueder, Hans Wedel, Giuseppe Rosano, Marcelo C Shibata, Alan Rigby, Marcus D Flather
BACKGROUND: Atrial fibrillation and heart failure often coexist, causing substantial cardiovascular morbidity and mortality. β blockers are indicated in patients with symptomatic heart failure with reduced ejection fraction; however, the efficacy of these drugs in patients with concomitant atrial fibrillation is uncertain. We therefore meta-analysed individual-patient data to assess the efficacy of β blockers in patients with heart failure and sinus rhythm compared with atrial fibrillation...
December 20, 2014: Lancet
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