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David Goldsmith

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https://www.readbyqxmd.com/read/30236082/renal-association-commentary-on-the-kdigo-2017-clinical-practice-guideline-update-for-the-diagnosis-evaluation-prevention-and-treatment-of-ckd-mbd
#1
James O Burton, David J Goldsmith, Nicki Ruddock, Rukshana Shroff, Mandy Wan
This report comments on the relevance and utility of the recently published (2017) KDIGO Clinical Practice Guideline Update for the diagnosis, evaluation, prevention and treatment of mineral bone disease in patients with chronic kidney disease (CKD-MBD) with respect to UK clinical practice. This document replaces all previously published Renal Association guidelines on the topic.
September 20, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30210015/preparing-for-a-foreign-animal-disease-outbreak-using-a-novel-tabletop-exercise
#2
Eric J Linskens, Abby E Neu, Emily J Walz, Kaitlyn M St Charles, Marie R Culhane, Amos Ssematimba, Timothy J Goldsmith, David A Halvorson, Carol J Cardona
IntroductionForeign animal disease (FAD) outbreaks can have devastating impacts, but they occur infrequently in any specific sector anywhere in the United States (US). Training to proactively discuss implementation of control and prevention strategies are beneficial in that they provide stakeholders with the practical information and educational experience they will need to respond effectively to an FAD. Such proactive approaches are the mission of the Secure Food System (SFS; University of Minnesota; St. Paul, Minnesota USA)...
September 13, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/30111863/high-dimensional-immune-phenotyping-and-transcriptional-analyses-reveal-robust-recovery-of-viable-human-immune-and-epithelial-cells-from-frozen-gastrointestinal-tissue
#3
Liza Konnikova, Gilles Boschetti, Adeeb Rahman, Vanessa Mitsialis, James Lord, Camilla Richmond, Vesselin T Tomov, Will Gordon, Scott Jelinsky, James Canavan, Andrew Liss, Sarah Wall, Michael Field, Fanny Zhou, Jeffery D Goldsmith, Meenakshi Bewtra, David T Breault, Miriam Merad, Scott B Snapper
Simultaneous analyses of peripheral and mucosal immune compartments can yield insight into the pathogenesis of mucosal-associated diseases. Although methods to preserve peripheral immune cells are well established, studies involving mucosal immune cells have been hampered by lack of simple storage techniques. We provide a cryopreservation protocol allowing for storage of gastrointestinal (GI) tissue with preservation of viability and functionality of both immune and epithelial cells. These methods will facilitate translational studies allowing for batch analysis of mucosal tissue to investigate disease pathogenesis, biomarker discovery and treatment responsiveness...
August 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/30104724/ras-nucleotide-cycling-underlies-the-shp2-phosphatase-dependence-of-mutant-braf-nf1-and-ras-driven-cancers
#4
Robert J Nichols, Franziska Haderk, Carlos Stahlhut, Christopher J Schulze, Golzar Hemmati, David Wildes, Christos Tzitzilonis, Kasia Mordec, Abby Marquez, Jason Romero, Tientien Hsieh, Aubhishek Zaman, Victor Olivas, Caroline McCoach, Collin M Blakely, Zhengping Wang, Gert Kiss, Elena S Koltun, Adrian L Gill, Mallika Singh, Mark A Goldsmith, Jacqueline A M Smith, Trever G Bivona
Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAFV600E -driven cancers, effective targeted therapies are lacking for most cancers driven by other pathway alterations, including non-V600E oncogenic BRAF, RAS GTPase-activating protein (GAP) NF1 (neurofibromin 1) loss and oncogenic KRAS. Here, we show that targeting the SHP2 phosphatase (encoded by PTPN11) with RMC-4550, a small-molecule allosteric inhibitor, is effective in human cancer models bearing RAS-GTP-dependent oncogenic BRAF (for example, class 3 BRAF mutants), NF1 loss or nucleotide-cycling oncogenic RAS (for example, KRASG12C )...
September 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29988387/establishing-monitored-premises-status-for-continuity-of-business-permits-during-an-hpai-outbreak
#5
Jamie Umber, Rebecca Johnson, Michelle Kromm, Eric Linskens, Marie R Culhane, Timothy Goldsmith, David Halvorson, Carol Cardona
Recent experiences with avian influenza outbreaks in poultry in the United States have tested biosecurity protocols and outbreak management strategies. During an outbreak, regulatory officials managing the emergency response need to make timely decisions in order to achieve disease control and eradication goals while simultaneously decreasing the unintended consequences of the response. To move susceptible animals or animal products out of a disease Control Area via a secure food supply continuity of business (COB) permit without the risk of expanding a disease outbreak, premises must be designated as Monitored Premises (MP) by regulatory officials...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29965864/sensitivity-to-melody-rhythm-and-beat-in-supporting-speech-in-noise-perception-in-young-adults
#6
Kathryn M Yates, David R Moore, Sygal Amitay, Johanna G Barry
OBJECTIVES: Musicians appear to have an enhanced ability to perceive speech-in-noise, prompting suggestions that musical training could be used to help people who struggle to communicate in noisy environments. This study assessed the role of sensitivity to beat, rhythm, and melody in supporting speech-in-noise perception. DESIGN: This is an exploratory study based on correlation. The study included 24 normally hearing young adult participants with a wide range of musical training and experience...
July 2, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29944418/re-titration-rates-after-clozapine-induced-neutropenia-or-agranulocytosis-a-case-report-and-literature-review
#7
Mina Boazak, Benjamin Kahn, Lindsay Cox, James Ragazino, David R Goldsmith, Robert O Cotes
Clozapine-induced neutropenia occurs in 3-5% of individuals treated with clozapine. Current US guidelines require interruption of clozapine when the absolute neutrophil count (ANC) drops below 1000 cells/mm3 . There is minimal available guidance for what dosing schedule to use when restarting clozapine after an episode of neutropenia. Here, we present a case of a 50-year-old Caucasian female with a history of schizoaffective disorder who was successfully rechallenged on clozapine one month after developing clozapine-induced neutropenia (ANC 600 cells/mm3 )...
June 26, 2018: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29909964/neonatal-onset-chronic-diarrhea-caused-by-homozygous-nonsense-wnt2b-mutations
#8
Amy E O'Connell, Fanny Zhou, Manasvi S Shah, Quinn Murphy, Hannah Rickner, Judith Kelsen, John Boyle, Jefferson J Doyle, Bharti Gangwani, Jay R Thiagarajah, Daniel S Kamin, Jeffrey D Goldsmith, Camilla Richmond, David T Breault, Pankaj B Agrawal
Homozygous nonsense mutations in WNT2B were identified in three individuals from two unrelated families with severe, neonatal-onset osmotic diarrhea after whole-exome sequencing was performed on trios from the two families. Intestinal biopsy samples from affected individuals were used for histology and immunofluorescence and to generate enteroids ex vivo. Histopathologic evaluation demonstrated chronic inflammatory changes in the stomach, duodenum, and colon. Immunofluorescence demonstrated diminished staining for OLFM4, a marker for intestinal stem cells (ISCs)...
July 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29895893/what-does-plasma-crp-tell-us-about-peripheral-and-central-inflammation-in-depression
#9
Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Miller
Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a subset of patients with major depressive disorder (MDD). Furthermore, increased peripheral blood CRP in MDD has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. Nevertheless, the relationship between peripheral CRP and other peripheral and central markers of inflammation in depressed patients has not been established...
June 12, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29889287/association-between-sickle-cell-trait-with-selected-chronic-medical-conditions-in-u-s-service-members
#10
David W Niebuhr, Ligong Chen, Stephanie Shao, Jonathan Goldsmith, Celia Byrne, Darrell E Singer
Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA. SCT has long been considered a benign condition with anticipated normal life expectancy and no increased risk for chronic diseases. The medical literature is inconclusive on the potential association between SCT and chronic medical conditions (CMC) including chronic kidney disease, venous thromboembolism, and stroke...
June 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29800779/antidepressant-treatment-resistance-is-associated-with-increased-inflammatory-markers-in-patients-with-major-depressive-disorder
#11
Ebrahim Haroon, Alexander W Daguanno, Bobbi J Woolwine, David R Goldsmith, Wendy M Baer, Evanthia C Wommack, Jennifer C Felger, Andrew H Miller
BACKGROUND: One third of patients with major depressive disorder (MDD) fail to respond to currently available antidepressant medications. Inflammation may contribute to treatment non-response through effects on neurotransmitter systems relevant to antidepressant efficacy. In post-hoc analyses, increased concentrations of inflammatory markers prior to treatment predict poor antidepressant response. However, limited data exists on whether depressed patients with multiple failed treatment trials in their current episode of depression exhibit increased inflammation...
September 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29795637/using-the-internet-for-suicide-related-purposes-contrasting-findings-from-young-people-in-the-community-and-self-harm-patients-admitted-to-hospital
#12
Lucy Biddle, Jane Derges, Carlie Goldsmith, Jenny L Donovan, David Gunnell
Despite accelerating interest in the impact of the internet on suicidal behaviour, empirical work has not captured detailed narratives from those who engaged in suicide-related internet use. This study explored the suicide-related online behaviour of two contrasting samples of distressed users, focusing on their purpose, methods and the main content viewed. In-depth interviews were conducted in the UK between 2014-2016 with i) young people in the community; and ii) self-harm patients presenting to hospital emergency departments...
2018: PloS One
https://www.readbyqxmd.com/read/29776692/risk-of-hospitalization-associated-with-body-mass-index-and-weight-changes-among-prevalent-haemodialysis-patients
#13
Juan J Carrero, Ivan Rodríguez-Cabezas, Abdul R Qureshi, Jürgen Floege, Markus Ketteler, Gerard London, Francesco Locatelli, Dimitrios Memmos, David Goldsmith, Aníbal Ferreira, Judit Nagy, Vladimir Teplan, Carlos Martínez-Salgado, José L Fernández-Martín, Carmine Zoccali, Jorge B Cannata-Andia
The impact of body mass index (BMI) and body weight on hospitalization rates in haemodialysis patients is unknown. This study hypothesizes that being either underweight or obese is associated with a higher hospitalization rate. Observational study of 6296 European haemodialysis patients with prospective data collection and follow-up every six months for three years (COSMOS study). The risk of being hospitalized was estimated by a time-dependent Cox regression model and the annual risk (incidence rate ratios, IRR) by Poisson regression...
May 15, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29754812/a-randomized-controlled-trial-to-evaluate-the-safety-and-efficacy-of-cardiac-contractility-modulation
#14
William T Abraham, Karl-Heinz Kuck, Rochelle L Goldsmith, JoAnn Lindenfeld, Vivek Y Reddy, Peter E Carson, Douglas L Mann, Benjamin Saville, Helen Parise, Rodrigo Chan, Phi Wiegn, Jeffrey L Hastings, Andrew J Kaplan, Frank Edelmann, Lars Luthje, Rami Kahwash, Gery F Tomassoni, David D Gutterman, Angela Stagg, Daniel Burkhoff, Gerd Hasenfuß
OBJECTIVES: The authors sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUND: CCM therapy for New York Heart Association (NYHA) functional class III and IV heart failure (HF) patients consists of nonexcitatory electrical signals delivered to the heart during the absolute refractory period...
May 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29595064/accelerating-drug-development-in-pediatric-cancer-a-novel-phase-i-study-design-of-venetoclax-in-relapsed-refractory-malignancies
#15
Andrew E Place, Kelly Goldsmith, Jean-Pierre Bourquin, Mignon L Loh, Lia Gore, Daniel A Morgenstern, Yeshwant Sanzgiri, David Hoffman, Ying Zhou, Jeremy A Ross, Betty Prine, Mohamad Shebley, Megan McNamee, Thalia Farazi, Su Young Kim, Maria Verdugo, Leanne Lash-Fleming, C Michel Zwaan, Josef Vormoor
Venetoclax is a highly selective, potent BCL-2 inhibitor that is approved for some patients previously treated for chronic lymphocytic leukemia, and has shown promising activity in adult studies across several hematologic malignancies. Preclinical studies have demonstrated venetoclax activity in pediatric patient-derived xenograft models and cell lines; however, clinical studies in pediatric patients have yet to be conducted. The prognosis is poor for children with most relapsed/refractory malignancies, and limited treatment options result in unmet clinical need...
September 2018: Future Oncology
https://www.readbyqxmd.com/read/29521452/genomes-of-ubiquitous-marine-and-hypersaline-hydrogenovibrio-thiomicrorhabdus-and-thiomicrospira-spp-encode-a-diversity-of-mechanisms-to-sustain-chemolithoautotrophy-in-heterogeneous-environments
#16
Kathleen M Scott, John Williams, Cody M B Porter, Sydney Russel, Tara L Harmer, John H Paul, Kirsten M Antonen, Megan K Bridges, Gary J Camper, Christie K Campla, Leila G Casella, Eva Chase, James W Conrad, Mercedez C Cruz, Darren S Dunlap, Laura Duran, Elizabeth M Fahsbender, Dawn B Goldsmith, Ryan F Keeley, Matthew R Kondoff, Breanna I Kussy, Marannda K Lane, Stephanie Lawler, Brittany A Leigh, Courtney Lewis, Lygia M Lostal, Devon Marking, Paola A Mancera, Evan C McClenthan, Emily A McIntyre, Jessica A Mine, Swapnil Modi, Brittney D Moore, William A Morgan, Kaleigh M Nelson, Kimmy N Nguyen, Nicholas Ogburn, David G Parrino, Anangamanjari D Pedapudi, Rebecca P Pelham, Amanda M Preece, Elizabeth A Rampersad, Jason C Richardson, Christina M Rodgers, Brent L Schaffer, Nancy E Sheridan, Michael R Solone, Zachery R Staley, Maki Tabuchi, Ramond J Waide, Pauline W Wanjugi, Suzanne Young, Alicia Clum, Chris Daum, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Natalia Mikhailova, Krishnaveni Palaniappan, Manoj Pillay, T B K Reddy, Nicole Shapiro, Dimitrios Stamatis, Neha Varghese, Tanja Woyke, Rich Boden, Sharyn K Freyermuth, Cheryl A Kerfeld
Chemolithoautotrophic bacteria from the genera Hydrogenovibrio, Thiomicrorhabdus and Thiomicrospira are common, sometimes dominant, isolates from sulfidic habitats including hydrothermal vents, soda and salt lakes and marine sediments. Their genome sequences confirm their membership in a deeply branching clade of the Gammaproteobacteria. Several adaptations to heterogeneous habitats are apparent. Their genomes include large numbers of genes for sensing and responding to their environment (EAL- and GGDEF-domain proteins and methyl-accepting chemotaxis proteins) despite their small sizes (2...
March 9, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29514337/the-association-between-sickle-cell-trait-in-u-s-service-members-with-deployment-length-of-service-and-mortality-1992-2012
#17
Darrell E Singer, Ligong Chen, Stephanie Shao, Jonathan Goldsmith, Celia Byrne, David W Niebuhr
Introduction: Sickle cell trait (SCT) affects an estimated 5.02% of non-Hispanic blacks, 1.08% of Hispanics, and 0.1% of Whites in the U.S. military. Policies for SCT screening and occupational restrictions vary by service. Population-based studies of SCT with quantification of military-relevant outcomes are lacking. Methods: The study design was a retrospective cohort of 15,081 SCT-positive versus 60,320 SCT-negative U.S. active duty personnel enlisted from 1992 to 2012 and followed through 2013...
March 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29500617/epoetin-biosimilars-in-the-treatment-of-renal-anemia-what-have-we-learned-from-a-decade-of-european-experience
#18
David Goldsmith, Frank Dellanna, Martin Schiestl, Andriy Krendyukov, Christian Combe
Biosimilars are biological medicines that are approved via stringently defined regulatory pathways on the basis that comparable safety, efficacy, and quality have been demonstrated to their reference medicine. The advantage of biosimilar drugs is that they may be less expensive than the reference medicine, allowing for greater patient access and cost savings in already stretched healthcare budgets. Biosimilar epoetins have been available in Europe for a decade. Complementing in vitro and preclinical characterization, and pharmacokinetic/pharmacodynamic studies, clinical trials provided the additional data needed to reassure European authorities that biosimilar epoetins were sufficiently similar to the reference epoetin to warrant approval...
June 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29499967/tnf-%C3%AE-and-il-6-are-associated-with-the-deficit-syndrome-and-negative-symptoms-in-patients-with-chronic-schizophrenia
#19
David R Goldsmith, Ebrahim Haroon, Andrew H Miller, Gregory P Strauss, Peter F Buckley, Brian J Miller
INTRODUCTION: Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. METHOD: We measured inflammatory markers in patients with and without deficit schizophrenia and controls. RESULTS: Using multivariate analyses, tumor necrosis factor (TNF)-α and interleukin-6 were associated with the deficit syndrome, and TNF-α predicted blunted affect, alogia, and total negative symptoms...
February 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29447181/innate-immune-responses-following-kawasaki-disease-and-toxic-shock-syndrome
#20
Katherine Y H Chen, Nicole Messina, Susie Germano, Rhian Bonnici, Bridget Freyne, Michael Cheung, Greta Goldsmith, Tobias R Kollmann, Michael Levin, David Burgner, Nigel Curtis
The pathogenesis of Kawasaki disease (KD) remains unknown and there is accumulating evidence for the importance of the innate immune system in initiating and mediating the host inflammatory response. We compared innate immune responses in KD and toxic shock syndrome (TSS) participants more than two years after their acute illness with control participants to investigate differences in their immune phenotype. Toxic shock syndrome shares many clinical features with KD; by including both disease groups we endeavoured to explore changes in innate immune responses following acute inflammatory illnesses more broadly...
2018: PloS One
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