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David Goldsmith

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https://www.readbyqxmd.com/read/29316898/inhibition-of-p38-mapk-activity-leads-to-cell-type-specific-effects-on-the-molecular-circadian-clock-and-time-dependent-reduction-of-glioma-cell-invasiveness
#1
Charles S Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L Gerard Toussaint, David J Earnest, Deborah Bell-Pedersen
BACKGROUND: The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression of clock-controlled genes throughout the body. MAPK signaling pathways function in both circadian input and output pathways in mammals depending on the tissue; however, little is known about the role of p38 MAPK, an established tumor suppressor, in the mammalian circadian system...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29296077/hx575-established-biosimilarity-in-the-treatment-of-renal-anemia-and-10-years-of-clinical-experience
#2
REVIEW
Frank Dellanna, David Goldsmith, Andriy Krendyukov, Andreas Seidl, Nadja Höbel, Christian Combe
Erythropoiesis-stimulating agents, such as recombinant human erythropoietin, are commonly used for the treatment of anemia in patients with chronic kidney disease (CKD). In 2007, HX575 (Binocrit®) became the first biosimilar epoetin alfa to be approved by the European Medicines Agency (EMA). The decision to approve a biosimilar is based on the totality of evidence obtained in a comprehensive comparability exercise that involves extensive analytical characterization, nonclinical studies and clinical studies...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29283590/tutorial-the-practical-application-of-longitudinal-structural-equation-mediation-models-in-clinical-trials
#3
Kimberley A Goldsmith, David P MacKinnon, Trudie Chalder, Peter D White, Michael Sharpe, Andrew Pickles
The study of mediation of treatment effects, or how treatments work, is important to understanding and improving psychological and behavioral treatments, but applications often focus on mediators and outcomes measured at a single time point. Such cross-sectional analyses do not respect the implied temporal ordering that mediation suggests. Clinical trials of treatments often provide repeated measures of outcomes and, increasingly, of mediators as well. Repeated measurements allow the application of various types of longitudinal structural equation mediation models...
December 28, 2017: Psychological Methods
https://www.readbyqxmd.com/read/29208494/bleeding-in-advanced-ckd-patients-on-antithrombotic-medication-a-critical-appraisal
#4
Alexandru Burlacu, Simonetta Genovesi, David Goldsmith, Patrick Rossignol, Alberto Ortiz, Philip A Kalra, Jolanta Małyszko, Maciej Banach, Mehmet Kanbay, Adrian Covic
Patients with advanced chronic kidney disease (CKD) are at an increased risk of bleeding, especially in the context of the complex therapeutic schemes of coronary artery disease (CAD) (from stable angina to acute coronary syndromes), atrial fibrillation or venous thromboembolism. The bleeding issue increases morbidity and mortality, a serious problem in daily medical practice. However, these patients are largely excluded from major randomized clinical trials, which results in the lack of medical evidence-based foundation for specific recommendations regarding antithrombotic treatment in a high bleeding risk setting...
December 2, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29168688/long-term-treatment-with-biosimilar-epoetin-%C3%AE-hx575-in-hemodialysis-patients-with-renal-anemia-real-world-effectiveness-and-safety-in-the-monitor-ckd5-study%C3%A2
#5
Gérard London, Johannes Mann, David Goldsmith, Christian Combe, Frank Dellanna, Philippe Zaoui, Nadja Hoebel, Andriy Krendyukov, Karen MacDonald, Ivo Abraham
AIMS: To assess real-world effectiveness and safety of intravenous (IV) HX575, a biosimilar epoetin-α, in hemodialysis (HD) patients. MATERIALS AND METHODS: This prospective, observational, pharmacoepidemiological study of adult HD patients treated with IV HX575 for renal anemia for up to 24 months was conducted in 114 centers in 10 European countries. Of 2,086 enrolled subjects (safety sample), 2,023 had ≥ 1 follow-up visit (effectiveness sample). RESULTS: Most (59...
November 23, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29127560/characteristics-of-medicaid-recipients-receiving-persistent-antipsychotic-polypharmacy
#6
Robert O Cotes, David R Goldsmith, Sarah L Kopelovich, Cathy A Lally, Benjamin G Druss
Antipsychotic polypharmacy (APP) is a common strategy despite guidelines advising against this practice. This article seeks to quantify the prevalence and correlates of APP using Medicaid Analytic eXtract files from 2003 to 2004. Nineteen percent of Medicaid recipients who received an antipsychotic were treated with APP. Individuals who received APP were more likely to be white, male, disabled, between the ages of 18-29, diagnosed with a psychotic disorder, and diagnosed with a higher number of psychiatric conditions...
November 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29114399/erratum-author-correction-identification-of-donor-microbe-species-that-colonize-and-persist-long-term-in-the-recipient-after-fecal-transplant-for-recurrent-clostridium-difficile
#7
Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T Goldsmith, Paula Dixon, David K Crossman, Michael R Crowley, Elliot J Lefkowitz, J Martin Rodriguez, Casey D Morrow
[This corrects the article DOI: 10.1038/s41522-017-0020-7.].
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29107998/impact-of-surgical-parathyroidectomy-on-chronic-kidney-disease-mineral-and-bone-disorder-ckd-mbd-a-systematic-review-and-meta-analysis
#8
REVIEW
Mugurel Apetrii, David Goldsmith, Ionut Nistor, Dimitrie Siriopol, Luminita Voroneanu, Dragos Scripcariu, Marc Vervloet, Adrian Covic
For more than 6 decades, many patients with advanced chronic kidney disease (CKD) have undergone surgical parathyroidectomy (sPTX) for severe secondary hyperparathyroidism (SHPT) mainly based historical clinical practice patterns, but not on evidence of outcome.We aimed in this meta-analysis to evaluate the benefits and harms of sPTX in patients with SHPT. We searched MEDLINE (inception to October 2016), EMBASE and Cochrane Library (through Issue 10 of 12, October 2016) and website clinicaltrials.gov (October 2016) without language restriction...
2017: PloS One
https://www.readbyqxmd.com/read/29106631/effect-of-renin-angiotensin-aldosterone-system-blockade-in-adults-with-diabetes-mellitus-and-advanced-chronic-kidney-disease-not-on-dialysis-a-systematic-review-and-meta-analysis
#9
Ionut Nistor, Johan De Sutter, Christiane Drechsler, David Goldsmith, Maria Jose Soler, Charles Tomson, Andrzej Wiecek, Mihaela-Dora Donciu, Davide Bolignano, Wim Van Biesen, Adrian Covic
The presumed superiority of renin-angiotensin-aldosterone system (RAAS)-blocking agents over other antihypertensive agents in patients with diabetes to delay development of end-stage kidney disease (ESKD) has recently been challenged. In addition, there is ongoing uncertainty whether RAAS-blocking agents reduce mortality and/or delay ESKD in patients with diabetes and chronic kidney disease (CKD) stages 3-5. In this subgroup, there might be an expedited need for renal replacement therapy (RRT) when RAAS-blocking agents are used...
July 2, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29079490/expedited-discharge-from-an-academic-emergency-department-a%C3%A2-pilot-program
#10
Andrew Goldsmith, Luis Ticona, Ryan Thompson, Benjamin A White, Joan Strauss, Robert Seger, David F M Brown, Ali S Raja, Brian J Yun
BACKGROUND: As the numbers of emergency department (ED) visits and inpatient admissions continue to increase, there is growing interest in alternatives to inpatient hospitalization. OBJECTIVE: Our aim was to investigate a novel approach to expediting discharges from the ED with multidisciplinary discharge services to prevent an avoidable admission into the hospital. METHODS: This pilot study was conducted at a large urban tertiary-care ED in 2016...
October 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29050900/bone-and-mineral-disorders-in-chronic-kidney-disease-implications-for-cardiovascular-health-and-ageing-in-the-general-population
#11
REVIEW
Adrian Covic, Marc Vervloet, Ziad A Massy, Pablo Ureña Torres, David Goldsmith, Vincent Brandenburg, Sandro Mazzaferro, Pieter Evenepoel, Jordi Bover, Mugurel Apetrii, Mario Cozzolino
The patient with chronic kidney disease (CKD) represents an extreme model for arteriosclerosis, vascular calcification, and bone disorders, all of which are also associated with ageing in the general population. These pathological features are also relevant to other common chronic health disorders such as diabetes, and chronic inflammatory and cardiovascular diseases. Although management and interventions for these major risk factors are now incorporated into most public health guidelines (eg, smoking cessation and control of bodyweight and blood pressure, as well as glucose and cholesterol concentrations), some residual cardiovascular risk is not reduced by implementation of these interventions...
October 16, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28968499/sculpting-fano-resonances-to-control-photonic-plasmonic-hybridization
#12
Niket Thakkar, Morgan T Rea, Kevin C Smith, Kevin D Heylman, Steven C Quillin, Kassandra A Knapper, Erik H Horak, David J Masiello, Randall H Goldsmith
Hybrid photonic-plasmonic systems have tremendous potential as versatile platforms for the study and control of nanoscale light-matter interactions since their respective components have either high-quality factors or low mode volumes. Individual metallic nanoparticles deposited on optical microresonators provide an excellent example where ultrahigh-quality optical whispering-gallery modes can be combined with nanoscopic plasmonic mode volumes to maximize the system's photonic performance. Such optimization, however, is difficult in practice because of the inability to easily measure and tune critical system parameters...
October 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/28940158/vitamin-d-and-osteoporosis-in-chronic-kidney-disease
#13
REVIEW
Paul Lips, David Goldsmith, Renate de Jongh
Osteoporotic fractures are common in patients with chronic kidney disease (CKD). Morbidity and mortality are higher in CKD patients with a fracture than in the general population. The assessment of bone mineral density for fracture prediction may be useful at all CKD stages. It should be considered when this influences treatment decisions. Vitamin D deficiency is common in patients with CKD, particularly in patients with proteinuria, due to loss of 25-hydroxyvitamin D and its binding protein. Vitamin D supplementation should be prescribed early in the course of renal disease...
October 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28805524/response-to-the-editorial-by-dr-geraghty
#14
Peter D White, Trudie Chalder, Michael Sharpe, Brian J Angus, Hannah L Baber, Jessica Bavinton, Mary Burgess, Lucy V Clark, Diane L Cox, Julia C DeCesare, Kimberley A Goldsmith, Anthony L Johnson, Paul McCrone, Gabrielle Murphy, Maurice Murphy, Hazel O'Dowd, Laura Potts, Rebacca Walwyn, David Wilks
This article is written in response to the linked editorial by Dr Geraghty about the adaptive Pacing, graded Activity and Cognitive behaviour therapy; a randomised Evaluation (PACE) trial, which we led, implemented and published. The PACE trial compared four treatments for people diagnosed with chronic fatigue syndrome. All participants in the trial received specialist medical care. The trial found that adding cognitive behaviour therapy or graded exercise therapy to specialist medical care was as safe as, and more effective than, adding adaptive pacing therapy or specialist medical care alone...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28756385/impact-of-intrapatient-variability-ipv-in-tacrolimus-trough-levels-on-long-term-renal-transplant-function-multicentre-collaborative-retrospective-cohort-study-protocol
#15
Petra M Goldsmith, Matthew J Bottomley, Okidi Okechukwu, Victoria C Ross, Ryan Ghita, David Wandless, Stuart J Falconer, Stavros Papachristos, Philip Nash, Vitaliy Androshchuk, Marc Clancy
INTRODUCTION: High intrapatient variability (IPV) in tacrolimus trough levels has been shown to be associated with higher rates of renal transplant failure. There is no consensus on what level of IPV constitutes a risk of graft loss. The establishment of such a threshold could help to guide clinicians in identifying at-risk patients to receive targeted interventions to improve IPV and thus outcomes. METHODS AND ANALYSIS: A multicentre Transplant Audit Collaborative has been established to conduct a retrospective study examining tacrolimus IPV and renal transplant outcomes...
July 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28699575/proposal-to-reclassify-ehrlichia-muris-as-ehrlichia-muris-subsp-muris-subsp-nov-and-description-of-ehrlichia-muris-subsp-eauclairensis-subsp-nov-a-newly-recognized-tick-borne-pathogen-of-humans
#16
Bobbi S Pritt, Michelle E J Allerdice, Lynne M Sloan, Christopher D Paddock, Ulrike G Munderloh, Yasuko Rikihisa, Tomoko Tajima, Susan M Paskewitz, David F Neitzel, Diep K Hoang Johnson, Elizabeth Schiffman, Jeffrey P Davis, Cynthia S Goldsmith, Curtis M Nelson, Sandor E Karpathy
We have previously described a novel taxon of the genus Ehrlichia (type strain WisconsinT), closely related to Ehrlichia muris, that causes human ehrlichiosis among patients with exposures to ticks in the upper midwestern USA. DNA from this bacterium was also detected in Ixodes scapularis and Peromyscus leucopus collected in Minnesota and Wisconsin. To determine the relationship between the E. muris-like agent (EMLA) and other species of the genus Ehrlichia phenotypic, genotypic and epidemiologic comparisons were undertaken, including sequence analysis of eight gene loci (3906 nucleotides) for 39 EMLA DNA samples and the type strain of E...
July 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28649413/identification-of-donor-microbe-species-that-colonize-and-persist-long-term-in-the-recipient-after-fecal-transplant-for-recurrent-clostridium-difficile
#17
Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T Goldsmith, Paula Dixon, David K Crossman, Michael R Crowley, Elliot J Lefkowitz, J Martin Rodriguez, Casey D Morrow
Fecal microbiota transplantation has been shown to be an effective treatment for patients with recurrent C. difficile colitis. Although fecal microbiota transplantation helps to re-establish a normal gut function in patients, the extent of the repopulation of the recipient microbial community varies. To further understand this variation, it is important to determine the fate of donor microbes in the patients following fecal microbiota transplantation. We have developed a new method that utilizes the unique single nucleotide variants of gut microbes to accurately identify microbes in paired fecal samples from the same individual taken at different times...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28628060/lung-cancer-risk-among-non-smoking-firefighters
#18
Tee Lamont Guidotti, David F Goldsmith
No abstract text is available yet for this article.
April 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28620996/feasibility-of-collecting-patient-reported-outcomes-for-inpatient-rehabilitation-quality-reporting
#19
Allen Walter Heinemann, Anne Deutsch, David Cella, Karon Frances Cook, Linda Foster, Ana Miskovic, Katharine Davis, Arielle Goldsmith
OBJECTIVE: To evaluate rehabilitation inpatients' willingness and ability to complete patient-reported outcomes (PROs) and the burden of completion on patients and staff. DATA SOURCES/STUDY SETTING: Two inpatient rehabilitation facilities. STUDY DESIGN: Patients with neurological disorders were assigned randomly to receive a nominal monetary incentive during or 1 month after the stay. DATA COLLECTION: Patients responded using a tablet computer or paper...
June 15, 2017: Health Services Research
https://www.readbyqxmd.com/read/28616220/impact-of-seasonality-on-the-dynamics-of-native-vitamin-d-repletion-in-long-term-renal-transplant-patients
#20
Oliver J Ziff, Hugo Penny, Sharon Frame, Antonia Cronin, David Goldsmith
Background: Renal transplant recipients (RTRs) are often Vitamin D (VitD) depleted as a result of both chronic kidney disease and mandated sun avoidance behaviours. Repleting VitD may be warranted, but how, and for how long, is unknown, as is the impact of seasonality on the success of repletion. We investigated the impact of seasonality on VitD status following VitD repletion in a large cohort of stable, long-term RTRs. Methods: Serum 25-hydroxyvitamin D [25(OH)D] concentrations and bone biochemistry parameters were analysed from 102 VitD repletion courses in 98 RTRs that had undergone VitD repletion...
June 2017: Clinical Kidney Journal
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