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David Goldsmith

Daniel A Hinton, James D Ng, Jian Sun, Stephen Lee, Semion K Saikin, Jenna Logsdon, David S White, Angela N Marquard, Andrew C Cavell, Veronica K Krasecki, Kassandra A Knapper, Katherine M Lupo, Michael R Wasielewski, Alán Aspuru-Guzik, Julie S Biteen, Padma Gopalan, Randall H Goldsmith
The interplay between micromorphology and electronic properties is an important theme in organic electronic materials. Here, we show that a spirofluorene-functionalized boron-dipyrromethene (BODIPY) with an alkyl norbornyl tail self-assembles into nanoparticles with qualitatively different properties as compared to the polymerized species. Further, the nanoparticles exhibit a host of unique emissive properties, including photobrightening, a blue satellite peak, and spectral diffusion. Extensive photophysical characterization, including single-particle imaging and spectroscopy, and time-resolved fluorescence, coupled with electronic structure calculations based on an experimentally determined crystal structure, allow a mechanism to be developed...
November 8, 2018: Journal of the American Chemical Society
Chi Yun Yu, Omar Saeed, Alyse S Goldberg, Shafaq Farooq, Rouhi Fazelzad, David P Goldstein, Richard W Tsang, James Brierley, Shereen Ezzat, Lehana Thabane, Charlie H Goldsmith, Anna M Sawka
BACKGROUND: The potential risk of subsequent malignant neoplasms (SMNs) after radioactive iodine (RAI) treatment of thyroid cancer (TC), is an important concern. METHODS: We updated a systematic review comparing the risk of SMNs in TC patients treated with RAI to TC patients without RAI. We searched six electronic databases (up to March, 2018), supplemented with a hand search. Two reviewers independently screened citations, reviewed full-text papers, and critically appraised/abstracted data...
October 27, 2018: Thyroid: Official Journal of the American Thyroid Association
Eleonora Maurizi, Davide Schiroli, Sarah D Atkinson, Laura Mairs, David G Courtney, Barry O'Hagan, Victoria E McGilligan, Alastair T Pagnamenta, Jenny C Taylor, Jesus J D Vasquez, Daniel E Illanes-Velarde, Dave Goldsmith, Pieter Gouws, Jonathan E Moore, M Andrew Nesbit, C B Tara Moore
Pterygium is a pathological proliferative condition of the ocular surface, characterised by formation of a highly vascularised, fibrous tissue arising from the limbus that invades the central cornea leading to visual disturbance and, if untreated, blindness. Whilst chronic ultraviolet (UV) light exposure plays a major role in its pathogenesis, higher susceptibility to pterygium is observed in some families, suggesting a genetic component. In this study, a Northern Irish family affected by pterygium but reporting little direct exposure to UV was identified carrying a missense variant in CRIM1 NM_016441...
October 24, 2018: Experimental Eye Research
Kaitlyn M St Charles, Amos Ssematimba, Sasidhar Malladi, Peter J Bonney, Eric Linskens, Marie Culhane, Timothy J Goldsmith, David A Halvorson, Carol J Cardona
Producing a smaller yield of higher-value birds compared to conventional poultry production, the U.S. commercial upland game bird industry deals primarily in the sale of live birds for recreational hunting. In this study, our aims were to gain insights into the occurrence of avian influenza (AI) in the U.S. commercial upland game bird industry in comparison to other poultry sectors, to identify the presence of the specific AI risk factors in the practices of raising ducks on site and having connections to live bird markets (LBMs), and to assess how AI surveillance systems may have played a role in the reporting of the presence of exposure pathway-related information...
September 2018: Avian Diseases
Hong Xu, Ali Hashem, Anna Witasp, Rik Mencke, David Goldsmith, Peter Barany, Annette Bruchfeld, Annika Wernerson, Juan-Jesus Carrero, Hannes Olauson
Background: Recent studies suggest that the phosphaturic hormone fibroblast growth factor 23 (FGF23) is involved in regulation of renal sodium excretion and blood pressure. There is evidence of both direct effects via regulation of the sodium-chloride symporter (NCC) in the distal tubule, and indirect effects through interactions with the renin-angiotensin-aldosterone system. However, clinical data on the association between FGF23 and renal sodium regulation is lacking. Herein, we investigated the associations of FGF23 with renal sodium handling and blood pressure in non-dialysis CKD patients...
October 11, 2018: Nephrology, Dialysis, Transplantation
Lisa M Broad, Helen E Sanger, Adrian J Mogg, Ellen M Colvin, Ruud Zwart, David A Evans, Francesca Pasqui, Emanuele Sher, Graham N Wishart, Vanessa N Barth, Christian C Felder, Paul J Goldsmith
BACKGROUND AND PURPOSE: The goal of this work was to identify and develop novel, selective muscarinic M1 receptor agonists as potential therapeutics for the symptomatic treatment of Alzheimer's disease. EXPERIMENTAL APPROACH: We developed and utilized a novel M1 receptor occupancy assay to drive a structure activity relationship in a relevant brain region, whilst simultaneously tracking drug levels in plasma and brain to optimize for central penetration. Functional activity was tracked in relevant native in vitro assays allowing translational (rat-human) benchmarking of SAR molecules to clinical comparators...
October 1, 2018: British Journal of Pharmacology
James O Burton, David J Goldsmith, Nicki Ruddock, Rukshana Shroff, Mandy Wan
This report comments on the relevance and utility of the recently published (2017) KDIGO Clinical Practice Guideline Update for the diagnosis, evaluation, prevention and treatment of mineral bone disease in patients with chronic kidney disease (CKD-MBD) with respect to UK clinical practice. This document replaces all previously published Renal Association guidelines on the topic.
September 20, 2018: BMC Nephrology
Eric J Linskens, Abby E Neu, Emily J Walz, Kaitlyn M St Charles, Marie R Culhane, Amos Ssematimba, Timothy J Goldsmith, David A Halvorson, Carol J Cardona
IntroductionForeign animal disease (FAD) outbreaks can have devastating impacts, but they occur infrequently in any specific sector anywhere in the United States (US). Training to proactively discuss implementation of control and prevention strategies are beneficial in that they provide stakeholders with the practical information and educational experience they will need to respond effectively to an FAD. Such proactive approaches are the mission of the Secure Food System (SFS; University of Minnesota; St. Paul, Minnesota USA)...
September 13, 2018: Prehospital and Disaster Medicine
Liza Konnikova, Gilles Boschetti, Adeeb Rahman, Vanessa Mitsialis, James Lord, Camilla Richmond, Vesselin T Tomov, Will Gordon, Scott Jelinsky, James Canavan, Andrew Liss, Sarah Wall, Michael Field, Fanny Zhou, Jeffery D Goldsmith, Meenakshi Bewtra, David T Breault, Miriam Merad, Scott B Snapper
Simultaneous analyses of peripheral and mucosal immune compartments can yield insight into the pathogenesis of mucosal-associated diseases. Although methods to preserve peripheral immune cells are well established, studies involving mucosal immune cells have been hampered by lack of simple storage techniques. We provide a cryopreservation protocol allowing for storage of gastrointestinal (GI) tissue with preservation of viability and functionality of both immune and epithelial cells. These methods will facilitate translational studies allowing for batch analysis of mucosal tissue to investigate disease pathogenesis, biomarker discovery and treatment responsiveness...
August 15, 2018: Mucosal Immunology
Robert J Nichols, Franziska Haderk, Carlos Stahlhut, Christopher J Schulze, Golzar Hemmati, David Wildes, Christos Tzitzilonis, Kasia Mordec, Abby Marquez, Jason Romero, Tientien Hsieh, Aubhishek Zaman, Victor Olivas, Caroline McCoach, Collin M Blakely, Zhengping Wang, Gert Kiss, Elena S Koltun, Adrian L Gill, Mallika Singh, Mark A Goldsmith, Jacqueline A M Smith, Trever G Bivona
Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAFV600E -driven cancers, effective targeted therapies are lacking for most cancers driven by other pathway alterations, including non-V600E oncogenic BRAF, RAS GTPase-activating protein (GAP) NF1 (neurofibromin 1) loss and oncogenic KRAS. Here, we show that targeting the SHP2 phosphatase (encoded by PTPN11) with RMC-4550, a small-molecule allosteric inhibitor, is effective in human cancer models bearing RAS-GTP-dependent oncogenic BRAF (for example, class 3 BRAF mutants), NF1 loss or nucleotide-cycling oncogenic RAS (for example, KRASG12C )...
September 2018: Nature Cell Biology
Jamie Umber, Rebecca Johnson, Michelle Kromm, Eric Linskens, Marie R Culhane, Timothy Goldsmith, David Halvorson, Carol Cardona
Recent experiences with avian influenza outbreaks in poultry in the United States have tested biosecurity protocols and outbreak management strategies. During an outbreak, regulatory officials managing the emergency response need to make timely decisions in order to achieve disease control and eradication goals while simultaneously decreasing the unintended consequences of the response. To move susceptible animals or animal products out of a disease Control Area via a secure food supply continuity of business (COB) permit without the risk of expanding a disease outbreak, premises must be designated as Monitored Premises (MP) by regulatory officials...
2018: Frontiers in Veterinary Science
Kathryn M Yates, David R Moore, Sygal Amitay, Johanna G Barry
OBJECTIVES: Musicians appear to have an enhanced ability to perceive speech-in-noise, prompting suggestions that musical training could be used to help people who struggle to communicate in noisy environments. This study assessed the role of sensitivity to beat, rhythm, and melody in supporting speech-in-noise perception. DESIGN: This is an exploratory study based on correlation. The study included 24 normally hearing young adult participants with a wide range of musical training and experience...
July 2, 2018: Ear and Hearing
Mina Boazak, Benjamin Kahn, Lindsay Cox, James Ragazino, David R Goldsmith, Robert O Cotes
Clozapine-induced neutropenia occurs in 3-5% of individuals treated with clozapine. Current US guidelines require interruption of clozapine when the absolute neutrophil count (ANC) drops below 1000 cells/mm3 . There is minimal available guidance for what dosing schedule to use when restarting clozapine after an episode of neutropenia. Here, we present a case of a 50-year-old Caucasian female with a history of schizoaffective disorder who was successfully rechallenged on clozapine one month after developing clozapine-induced neutropenia (ANC 600 cells/mm3 )...
June 26, 2018: Clinical Schizophrenia & related Psychoses
Amy E O'Connell, Fanny Zhou, Manasvi S Shah, Quinn Murphy, Hannah Rickner, Judith Kelsen, John Boyle, Jefferson J Doyle, Bharti Gangwani, Jay R Thiagarajah, Daniel S Kamin, Jeffrey D Goldsmith, Camilla Richmond, David T Breault, Pankaj B Agrawal
Homozygous nonsense mutations in WNT2B were identified in three individuals from two unrelated families with severe, neonatal-onset osmotic diarrhea after whole-exome sequencing was performed on trios from the two families. Intestinal biopsy samples from affected individuals were used for histology and immunofluorescence and to generate enteroids ex vivo. Histopathologic evaluation demonstrated chronic inflammatory changes in the stomach, duodenum, and colon. Immunofluorescence demonstrated diminished staining for OLFM4, a marker for intestinal stem cells (ISCs)...
July 5, 2018: American Journal of Human Genetics
Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Miller
Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a subset of patients with major depressive disorder (MDD). Furthermore, increased peripheral blood CRP in MDD has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. Nevertheless, the relationship between peripheral CRP and other peripheral and central markers of inflammation in depressed patients has not been established...
June 12, 2018: Molecular Psychiatry
David W Niebuhr, Ligong Chen, Stephanie Shao, Jonathan Goldsmith, Celia Byrne, Darrell E Singer
Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA. SCT has long been considered a benign condition with anticipated normal life expectancy and no increased risk for chronic diseases. The medical literature is inconclusive on the potential association between SCT and chronic medical conditions (CMC) including chronic kidney disease, venous thromboembolism, and stroke...
June 8, 2018: Military Medicine
Ebrahim Haroon, Alexander W Daguanno, Bobbi J Woolwine, David R Goldsmith, Wendy M Baer, Evanthia C Wommack, Jennifer C Felger, Andrew H Miller
BACKGROUND: One third of patients with major depressive disorder (MDD) fail to respond to currently available antidepressant medications. Inflammation may contribute to treatment non-response through effects on neurotransmitter systems relevant to antidepressant efficacy. In post-hoc analyses, increased concentrations of inflammatory markers prior to treatment predict poor antidepressant response. However, limited data exists on whether depressed patients with multiple failed treatment trials in their current episode of depression exhibit increased inflammation...
September 2018: Psychoneuroendocrinology
Lucy Biddle, Jane Derges, Carlie Goldsmith, Jenny L Donovan, David Gunnell
Despite accelerating interest in the impact of the internet on suicidal behaviour, empirical work has not captured detailed narratives from those who engaged in suicide-related internet use. This study explored the suicide-related online behaviour of two contrasting samples of distressed users, focusing on their purpose, methods and the main content viewed. In-depth interviews were conducted in the UK between 2014-2016 with i) young people in the community; and ii) self-harm patients presenting to hospital emergency departments...
2018: PloS One
Juan J Carrero, Ivan Cabezas-Rodríguez, Abdul R Qureshi, Jürgen Floege, Markus Ketteler, Gerard London, Francesco Locatelli, Dimitrios Memmos, David Goldsmith, Aníbal Ferreira, Judit Nagy, Vladimir Teplan, Carlos Martínez-Salgado, José L Fernández-Martín, Carmine Zoccali, Jorge B Cannata-Andia
The impact of body mass index (BMI) and body weight on hospitalization rates in haemodialysis patients is unknown. This study hypothesizes that being either underweight or obese is associated with a higher hospitalization rate. Observational study of 6296 European haemodialysis patients with prospective data collection and follow-up every six months for three years (COSMOS study). The risk of being hospitalized was estimated by a time-dependent Cox regression model and the annual risk (incidence rate ratios, IRR) by Poisson regression...
September 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
William T Abraham, Karl-Heinz Kuck, Rochelle L Goldsmith, JoAnn Lindenfeld, Vivek Y Reddy, Peter E Carson, Douglas L Mann, Benjamin Saville, Helen Parise, Rodrigo Chan, Phi Wiegn, Jeffrey L Hastings, Andrew J Kaplan, Frank Edelmann, Lars Luthje, Rami Kahwash, Gery F Tomassoni, David D Gutterman, Angela Stagg, Daniel Burkhoff, Gerd Hasenfuß
OBJECTIVES: The authors sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUND: CCM therapy for New York Heart Association (NYHA) functional class III and IV heart failure (HF) patients consists of nonexcitatory electrical signals delivered to the heart during the absolute refractory period...
May 5, 2018: JACC. Heart Failure
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