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Darrel Francis

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https://www.readbyqxmd.com/read/29984912/rationale-and-design-of-the-randomized-multicentre-his-optimized-pacing-evaluated-for-heart-failure-hope-hf-trial
#1
Daniel Keene, Ahran Arnold, Matthew J Shun-Shin, James P Howard, Sm Afzal Sohaib, Philip Moore, Mark Tanner, Norman Quereshi, Amal Muthumala, Badrinathan Chandresekeran, Paul Foley, Francisco Leyva, Shaumik Adhya, Emanuela Falaschetti, Hilda Tsang, Pugal Vijayaraman, John G F Cleland, Berthold Stegemann, Darrel P Francis, Zachary I Whinnett
AIMS: In patients with heart failure and a pathologically prolonged PR interval, left ventricular (LV) filling can be improved by shortening atrioventricular delay using His-bundle pacing. His-bundle pacing delivers physiological ventricular activation and has been shown to improve acute haemodynamic function in this group of patients. In the HOPE-HF (His Optimized Pacing Evaluated for Heart Failure) trial, we are investigating whether these acute haemodynamic improvements translate into improvements in exercise capacity and heart failure symptoms...
July 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29946558/left-ventricular-scar-and-the-acute-hemodynamic-effects-of-multivein-and-multipolar-pacing-in-cardiac-resynchronization
#2
Tom Jackson, Radoslaw Lenarczyk, Maciej Sterlinski, Adam Sokal, Darrell Francis, Zachary Whinnett, Frederic Van Heuverswyn, Marc Vanderheyden, Joeri Heynens, Berthold Stegemann, Richard Cornelussen, Christopher Aldo Rinaldi
Background: We sought to determine whether presence, amount and distribution of scar impacts the degree of acute hemodynamic response (AHR) with multisite pacing.Multi-vein pacing (MVP) or multipolar pacing (MPP) with a multi-electrode left ventricular (LV) lead may offer benefits over conventional biventricular pacing in patients with myocardial scar. Methods: In this multi-center study left bundle branch block patients underwent an hemodynamic pacing study measuring LV dP/dtmax ...
June 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29935058/regression-of-left-ventricular-hypertrophy-provides-an-additive-physiological-benefit-following-treatment-of-aortic-stenosis-insights-from-serial-coronary-wave-intensity-analysis
#3
Christopher J Broyd, Fausto Rigo, Sukhjinder Nijjer, Sayan Sen, Ricardo Petraco, Rasha Al-Lamee, Nicolas Foin, Andrew Chukwuemeka, Jon Anderson, Jessica Parker, Iqbal S Malik, Ghada W Mikhail, Darrel P Francis, Kim Parker, Alun D Hughes, Jamil Mayet, Justin E Davies
AIM: Severe aortic stenosis frequently involves the development of left ventricular hypertrophy (LVH) creating a dichotomous hemodynamic state within the coronary circulation. Whilst the increased force of ventricular contraction enhances its resultant relaxation and thus increases the distal diastolic coronary 'suction' force, the presence of LVH has a potentially opposing effect on ventricular-coronary interplay. The aim of this study was to use non-invasive coronary wave-intensity analysis (WIA) to separate and measure the sequential effects of outflow-tract obstruction relief and then left ventricular hypertrophy (LVH) regression following intervention for aortic stenosis...
June 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29789302/fractional-flow-reserve-and-instantaneous-wave-free-ratio-as-predictors-of-the-placebo-controlled-response-to-percutaneous-coronary-intervention-in-stable-single-vessel-coronary-artery-disease-physiology-stratified-analysis-of-orbita
#4
Rasha Al-Lamee, James P Howard, Matthew J Shun-Shin, David Thompson, Hakim-Moulay Dehbi, Sayan Sen, Sukhjinder Nijjer, Ricardo Petraco, John Davies, Thomas Keeble, Kare Tang, Iqbal S Malik, Christopher Cook, Yousif Ahmad, Andrew S P Sharp, Robert Gerber, Christopher Baker, Raffi Kaprielian, Suneel Talwar, Ravi Assomull, Graham Cole, Niall G Keenan, Gajen Kanaganayagam, Joban Sehmi, Roland Wensel, Frank E Harrell, Jamil Mayet, Simon A Thom, Justin E Davies, Darrel P Francis
BACKGROUND : There are no data on how fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are associated with the placebo-controlled efficacy of percutaneous coronary intervention (PCI) in stable single-vessel coronary artery disease. METHODS : We report the association between prerandomization invasive physiology within ORBITA (Objective Randomised Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina), a placebo-controlled trial of patients who have stable angina with angiographically severe single-vessel coronary disease clinically eligible for PCI...
May 22, 2018: Circulation
https://www.readbyqxmd.com/read/29778861/multicenter-randomized-controlled-crossover-trial-comparing-hemodynamic-optimization-against-echocardiographic-optimization-of-av-and-vv-delay-of-cardiac-resynchronization-therapy-the-bravo-trial
#5
Zachary I Whinnett, S M Afzal Sohaib, Mark Mason, Edward Duncan, Mark Tanner, David Lefroy, Mohamed Al-Obaidi, Sue Ellery, Francisco Leyva-Leon, Tim Betts, Mark Dayer, Paul Foley, Jon Swinburn, Martin Thomas, Raj Khiani, Tom Wong, Zaheer Yousef, Dominic Rogers, Paul R Kalra, Vignesh Dhileepan, Katherine March, James Howard, Andreas Kyriacou, Jamil Mayet, Prapa Kanagaratnam, Michael Frenneaux, Alun D Hughes, Darrel P Francis
OBJECTIVES: BRAVO (British Randomized Controlled Trial of AV and VV Optimization) is a multicenter, randomized, crossover, noninferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular delay with a noninvasive blood pressure method. BACKGROUND: Cardiac resynchronization therapy including AV delay optimization confers clinical benefit, but the optimization requires time and expertise to perform. METHODS: This study randomized patients to echocardiographic optimization or hemodynamic optimization using multiple-replicate beat-by-beat noninvasive blood pressure at baseline; after 6 months, participants were crossed over to the other optimization arm of the trial...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29682209/-89-zr-nimotuzumab-for-immunopet-imaging-of-epidermal-growth-factor-receptor-i
#6
Rufael Chekol, Viswas Raja Solomon, Elahe Alizadeh, Wendy Bernhard, Darrell Fisher, Wayne Hill, Kris Barreto, John Francis DeCoteau, Angel Casaco Parada, Clarence Ronald Geyer, Humphrey Fonge
Rationale: Epidermal growth factor receptor (EGFR) upregulation is associated with enhanced proliferation and drug resistance in a number of cancers. Nimotuzumab is a humanized monoclonal antibody with high affinity for EGFR. The objective of this study was to determine if 89 Zr-DFO-nimotuzumab could be suitable for human use as a PET probe for quantifying EGFR in vivo . Methods: To evaluate the pharmacokinetics, biodistribution, microPET imaging, radiation dosimetry, and normal tissue toxicity in tumor and non-tumor bearing mice of 89 Zr-desferoxamine-nimotuzumab (89 Zr-DFO-nimotuzumab) of a product prepared under GMP conditions...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29677303/association-between-use-of-sodium-glucose-cotransporter-2-inhibitors-glucagon-like-peptide-1-agonists-and-dipeptidyl-peptidase-4-inhibitors-with-all-cause-mortality-in-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#7
REVIEW
Sean L Zheng, Alistair J Roddick, Rochan Aghar-Jaffar, Matthew J Shun-Shin, Darrel Francis, Nick Oliver, Karim Meeran
Importance: The comparative clinical efficacy of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors for treatment of type 2 diabetes is unknown. Objective: To compare the efficacies of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors on mortality and cardiovascular end points using network meta-analysis. Data Sources: MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, and published meta-analyses from inception through October 11, 2017...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29673507/pre-angioplasty-instantaneous-wave-free-ratio-pullback-predicts-hemodynamic-outcome-in-humans-with-coronary-artery-disease-primary-results-of-the-international-multicenter-ifr-gradient-registry
#8
Yuetsu Kikuta, Christopher M Cook, Andrew S P Sharp, Pablo Salinas, Yoshiaki Kawase, Yasutsugu Shiono, Alessandra Giavarini, Masafumi Nakayama, Salvatore De Rosa, Sayan Sen, Sukhjinder S Nijjer, Rasha Al-Lamee, Ricardo Petraco, Iqbal S Malik, Ghada W Mikhail, Raffi R Kaprielian, Gilbert W M Wijntjens, Shinsuke Mori, Arata Hagikura, Martin Mates, Atsushi Mizuno, Farrel Hellig, Kelvin Lee, Luc Janssens, Kazunori Horie, Shah Mohdnazri, Raul Herrera, Florian Krackhardt, Masahiro Yamawaki, John Davies, Hideo Takebayashi, Thomas Keeble, Seiichi Haruta, Flavio Ribichini, Ciro Indolfi, Jamil Mayet, Darrel P Francis, Jan J Piek, Carlo Di Mario, Javier Escaned, Hitoshi Matsuo, Justin E Davies
OBJECTIVES: The authors sought to evaluate the accuracy of instantaneous wave-Free Ratio (iFR) pullback measurements to predict post-percutaneous coronary intervention (PCI) physiological outcomes, and to quantify how often iFR pullback alters PCI strategy in real-world clinical settings. BACKGROUND: In tandem and diffuse disease, offline analysis of continuous iFR pullback measurement has previously been demonstrated to accurately predict the physiological outcome of revascularization...
April 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29590333/patent-foramen-ovale-closure-vs-medical-therapy-for-cryptogenic-stroke-a-meta-analysis-of-randomized-controlled-trials
#9
Yousif Ahmad, James P Howard, Ahran Arnold, Matthew Shun Shin, Christopher Cook, Ricardo Petraco, Ozan Demir, Luke Williams, Juan F Iglesias, Nilesh Sutaria, Iqbal Malik, Justin Davies, Jamil Mayet, Darrel Francis, Sayan Sen
Aims: The efficacy of patent foramen ovale (PFO) closure for cryptogenic stroke has been controversial. We undertook a meta-analysis of randomized controlled trials (RCTs) comparing device closure with medical therapy to prevent recurrent stroke for patients with PFO. Methods and results: We systematically identified all RCTs comparing device closure to medical therapy for cryptogenic stroke in patients with PFO. The primary efficacy endpoint was recurrent stroke, analysed on an intention-to-treat basis...
May 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29530888/moving-the-goalposts-into-unblinded-territory-the-larger-lessons-of-defer-and-fame-2-and-their-implications-for-shifting-end-points-in-ischemia
#10
Christopher A Rajkumar, Sukhjinder S Nijjer, Graham D Cole, Rasha Al-Lamee, Darrel P Francis
No abstract text is available yet for this article.
March 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29458408/catheter-ablation-versus-thoracoscopic-surgical-ablation-in-long-standing-persistent-atrial-fibrillation-casa-af-study-protocol-for-a-randomised-controlled-trial
#11
Habib Rehman Khan, Ines Kralj-Hans, Shouvik Haldar, Toufan Bahrami, Jonathan Clague, Anthony De Souza, Darrel Francis, Wajid Hussain, Julian Jarman, David Gareth Jones, Neeraj Mediratta, Raad Mohiaddin, Tushar Salukhe, Simon Jones, Joanne Lord, Caroline Murphy, Joanna Kelly, Vias Markides, Dhiraj Gupta, Tom Wong
BACKGROUND: Atrial fibrillation is the commonest arrhythmia which raises the risk of heart failure, thromboembolic stroke, morbidity and death. Pharmacological treatments of this condition are focused on heart rate control, rhythm control and reduction in risk of stroke. Selective ablation of cardiac tissues resulting in isolation of areas causing atrial fibrillation is another treatment strategy which can be delivered by two minimally invasive interventions: percutaneous catheter ablation and thoracoscopic surgical ablation...
February 20, 2018: Trials
https://www.readbyqxmd.com/read/29387433/optimal-antiplatelet-strategy-after-transcatheter-aortic-valve-implantation-a-meta-analysis
#12
Yousif Ahmad, Ozan Demir, Christopher Rajkumar, James P Howard, Matthew Shun-Shin, Christopher Cook, Ricardo Petraco, Richard Jabbour, Ahran Arnold, Angela Frame, Nilesh Sutaria, Ben Ariff, Gajen Kanaganayagam, Darrel Francis, Jamil Mayet, Ghada Mikhail, Iqbal Malik, Sayan Sen
Objective: International guidelines recommend the use of dual antiplatelet therapy (DAPT) after transcatheter aortic valve implantation (TAVI). The recommended duration of DAPT varies between guidelines. In this two-part study, we (1) performed a structured survey of 45 TAVI centres from around the world to determine if there is consensus among clinicians regarding antiplatelet therapy after TAVI; and then (2) performed a systematic review of all suitable studies (randomised controlled trials (RCTs) and registries) to determine if aspirin monotherapy can be used instead of DAPT...
2018: Open Heart
https://www.readbyqxmd.com/read/29387424/effects-of-disease-severity-distribution-on-the-performance-of-quantitative-diagnostic-methods-and-proposal-of-a-novel-v-plot-methodology-to-display-accuracy-values
#13
Ricardo Petraco, Hakim-Moulay Dehbi, James P Howard, Matthew J Shun-Shin, Sayan Sen, Sukhjinder S Nijjer, Jamil Mayet, Justin E Davies, Darrel P Francis
Background: Diagnostic accuracy is widely accepted by researchers and clinicians as an optimal expression of a test's performance. The aim of this study was to evaluate the effects of disease severity distribution on values of diagnostic accuracy as well as propose a sample-independent methodology to calculate and display accuracy of diagnostic tests. Methods and findings: We evaluated the diagnostic relationship between two hypothetical methods to measure serum cholesterol (Cholrapid and Cholgold ) by generating samples with statistical software and (1) keeping the numerical relationship between methods unchanged and (2) changing the distribution of cholesterol values...
2018: Open Heart
https://www.readbyqxmd.com/read/29346531/doppler-assessment-of-aortic-stenosis-a-25-operator-study-demonstrating-why-reading-the-peak-velocity-is-superior-to-velocity-time-integral
#14
Stefania Sacchi, Niti M Dhutia, Matthew J Shun-Shin, Massoud Zolgharni, Nilesh Sutaria, Darrel P Francis, Graham D Cole
Aims: Measurements with superior reproducibility are useful clinically and research purposes. Previous reproducibility studies of Doppler assessment of aortic stenosis (AS) have compared only a pair of observers and have not explored the mechanism by which disagreement between operators occurs. Using custom-designed software which stored operators' traces, we investigated the reproducibility of peak and velocity time integral (VTI) measurements across a much larger group of operators and explored the mechanisms by which disagreement arose...
January 15, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29208573/swimming-against-the-tide-insights-from-the-orbita-trial
#15
Rasha Al-Lamee, Darrel P Francis
No abstract text is available yet for this article.
December 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29169764/female-specific-survival-advantage-from-transcatheter-aortic-valve-implantation-over-surgical-aortic-valve-replacement-meta-analysis-of-the-gender-subgroups-of-randomised-controlled-trials-including-3758-patients
#16
Vasileios F Panoulas, Darrel P Francis, Neil Ruparelia, Iqbal S Malik, Andrew Chukwuemeka, Sayan Sen, Jonathan Anderson, Petros Nihoyannopoulos, Nilesh Sutaria, Edward L Hannan, Zaza Samadashvili, Paola D'Errigo, Gerhard Schymik, Roxana Mehran, Alaide Chieffo, Azeem Latib, Patrizia Presbitero, Julinda Mehilli, Anna Sonia Petronio, Marie-Claude Morice, Corrado Tamburino, Hans G H Thyregod, Martin Leon, Antonio Colombo, Ghada W Mikhail
Transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) is the first area of interventional cardiology where women are treated as often as men. In this analysis of the gender specific results of randomised controlled trials (RCTs) comparing TAVI with surgical aortic valve replacement (SAVR) we aimed to determine whether gender affects the survival comparison between TAVI and SAVR. We identified all RCTs comparing TAVI versus SAVR for severe AS and reporting 1 and/or 2year survival. Summary odds ratios (ORs) were obtained using a random-effects model...
January 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29103656/percutaneous-coronary-intervention-in-stable-angina-orbita-a-double-blind-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Rasha Al-Lamee, David Thompson, Hakim-Moulay Dehbi, Sayan Sen, Kare Tang, John Davies, Thomas Keeble, Michael Mielewczik, Raffi Kaprielian, Iqbal S Malik, Sukhjinder S Nijjer, Ricardo Petraco, Christopher Cook, Yousif Ahmad, James Howard, Christopher Baker, Andrew Sharp, Robert Gerber, Suneel Talwar, Ravi Assomull, Jamil Mayet, Roland Wensel, David Collier, Matthew Shun-Shin, Simon A Thom, Justin E Davies, Darrel P Francis
BACKGROUND: Symptomatic relief is the primary goal of percutaneous coronary intervention (PCI) in stable angina and is commonly observed clinically. However, there is no evidence from blinded, placebo-controlled randomised trials to show its efficacy. METHODS: ORBITA is a blinded, multicentre randomised trial of PCI versus a placebo procedure for angina relief that was done at five study sites in the UK. We enrolled patients with severe (≥70%) single-vessel stenoses...
January 6, 2018: Lancet
https://www.readbyqxmd.com/read/29091329/repolarization-abnormalities-unmasked-with-exercise-in-sudden-cardiac-death-survivors-with-structurally-normal-hearts
#18
Kevin M W Leong, Fu Siong Ng, Caroline Roney, Christopher Cantwell, Matthew J Shun-Shin, Nicholas W F Linton, Zachary I Whinnett, David C Lefroy, D Wyn Davies, Sian E Harding, Phang Boon Lim, Darrel Francis, Nicholas S Peters, Amanda M Varnava, Prapa Kanagaratnam
BACKGROUND: Models of cardiac arrhythmogenesis predict that nonuniformity in repolarization and/or depolarization promotes ventricular fibrillation and is modulated by autonomic tone, but this is difficult to evaluate in patients. We hypothesize that such spatial heterogeneities would be detected by noninvasive ECG imaging (ECGi) in sudden cardiac death (SCD) survivors with structurally normal hearts under physiological stress. METHODS: ECGi was applied to 11 SCD survivors, 10 low-risk Brugada syndrome patients (BrS), and 10 controls undergoing exercise treadmill testing...
January 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29016722/hierarchical-statistical-techniques-are-necessary-to-draw-reliable-conclusions-from-analysis-of-isolated-cardiomyocyte-studies
#19
Markus B Sikkel, Darrel P Francis, James Howard, Fabiana Gordon, Christina Rowlands, Nicholas S Peters, Alexander R Lyon, Sian E Harding, Kenneth T MacLeod
Aims: It is generally accepted that post-MI heart failure (HF) changes a variety of aspects of sarcoplasmic reticular Ca2+ fluxes but for some aspects there is disagreement over whether there is an increase or decrease. The commonest statistical approach is to treat data collected from each cell as independent, even though they are really clustered with multiple likely similar cells from each heart. In this study, we test whether this statistical assumption of independence can lead the investigator to draw conclusions that would be considered erroneous if the analysis handled clustering with specific statistical techniques (hierarchical tests)...
December 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28749898/recurrence-of-granular-corneal-dystrophy-type-1-after-phototherapeutic-keratectomy-lamellar-keratoplasty-and-penetrating-keratoplasty-in-a-single-population
#20
COMPARATIVE STUDY
Darrell R Lewis, Marianne O Price, Matthew T Feng, Francis W Price
PURPOSE: To describe the recurrence of granular corneal dystrophy type 1 (GCD1) after penetrating keratoplasty (PKP), anterior lamellar keratoplasty (ALK), deep anterior lamellar keratoplasty (DALK), and phototherapeutic keratectomy (PTK) in a single population. The time required to achieve best-corrected visual acuity (BCVA) after each intervention was also analyzed. METHODS: Retrospective review of all patients with GCD1 from a single center between 1989 and 2016...
October 2017: Cornea
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