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Paul Carter

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https://www.readbyqxmd.com/read/29628187/reciprocal-circuits-linking-the-prefrontal-cortex-with-dorsal-and-ventral-thalamic-nuclei
#1
David P Collins, Paul G Anastasiades, Joseph J Marlin, Adam G Carter
Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics to dissect the specificity and dynamics of cortico-thalamo-cortical networks in the mouse brain. We find that cortico-thalamic (CT) neurons in prelimbic PFC project to both mediodorsal (MD) and ventromedial (VM) thalamus, where layer 5 and 6 inputs activate thalamo-cortical (TC) neurons with distinct temporal profiles. We show that TC neurons in MD and VM in turn make distinct connections in PFC, with MD preferentially and strongly activating layer 2/3 cortico-cortical (CC) neurons...
April 4, 2018: Neuron
https://www.readbyqxmd.com/read/29617058/multicenter-randomized-controlled-observer-blinded-study-of-a-nitric-oxide-generating-treatment-in-foot-ulcers-of-patients-with-diabetes-pronox1-study
#2
Michael E Edmonds, Harvey J Bodansky, Andrew Jm Boulton, Paul J Chadwick, Cuong N Dang, Ryan D'Costa, Atholl Johnston, Brian Kennon, Graham Leese, Satyan M Rajbhandari, Thomas E Serena, Matthew J Young, Joanne E Stewart, Arthur T Tucker, Marissa J Carter
The aim of this multi-center, prospective, observer-blinded, parallel group, randomized controlled trial was to assess the safety and efficacy of EDX110, a nitric oxide generating medical device, in the treatment of diabetic foot ulcers in a patient group reflecting "real world" clinical practice compared against optimal standard care. Participants were recruited from ten hospital sites in multidisciplinary foot ulcer clinics. The ulcers were full thickness, with an area of 25-2500mm2 and either a palpable pedal pulse or ankle brachial pressure index >0...
April 4, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29613965/mr-imaging-of-cardiac-masses
#3
John P Lichtenberger, Adam R Dulberger, Paul E Gonzales, Juliana Bueno, Brett W Carter
Cardiac masses present a diagnostic challenge given their relative rarity and the overall difficulty imaging the heart. With the increasing frequency and quality of imaging in general, however, the incidental discovery of cardiac masses is increasing. Cardiac masses seldom produce symptoms, and they are more commonly found during imaging for noncardiac indications. While echocardiography is useful in the initial evaluation of a suspected mass, cardiac magnetic resonance (MR) imaging is the best imaging modality to characterize cardiac tumors due to its superior tissue characterization and its higher contrast resolution...
April 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29610713/ultrasound-for-volume-assessment-in-patients-with-shock-effectiveness-of-an-educational-intervention-for-fourth-year-medical-students
#4
Paul Kukulski, Michael Ward, Keme Carter
Objective Shock is a common emergency condition with high morbidity and mortality, and judicious fluid resuscitation can significantly affect outcomes. The use of a bedside echocardiogram and evaluation of the inferior vena cava (IVC) via ultrasound (US) for collapsibility can predict volume status. Additionally, the Association of American Medical Colleges (AAMC) Entrustable Professional Activities (EPA) 10 states that residents need to be able to address a patient with a critical illness, including hypotension, on Day 1 of residency...
January 30, 2018: Curēus
https://www.readbyqxmd.com/read/29610481/a-global-transcriptional-network-connecting-noncoding-mutations-to-changes-in-tumor-gene-expression
#5
Wei Zhang, Ana Bojorquez-Gomez, Daniel Ortiz Velez, Guorong Xu, Kyle S Sanchez, John Paul Shen, Kevin Chen, Katherine Licon, Collin Melton, Katrina M Olson, Michael Ku Yu, Justin K Huang, Hannah Carter, Emma K Farley, Michael Snyder, Stephanie I Fraley, Jason F Kreisberg, Trey Ideker
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes, identifying a network of 193 noncoding loci in which mutations disrupt target gene expression. These 'somatic eQTLs' (expression quantitative trait loci) are frequently mutated in specific cancer tissues, and the majority can be validated in an independent cohort of 3,382 tumors. Among these, we find that the effects of noncoding mutations on DAAM1, MTG2 and HYI transcription are recapitulated in multiple cancer cell lines and that increasing DAAM1 expression leads to invasive cell migration...
April 2, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29605187/antipsychotic-drugs-versus-cognitive-behavioural-therapy-versus-a-combination-of-both-in-people-with-psychosis-a-randomised-controlled-pilot-and-feasibility-study
#6
Anthony P Morrison, Heather Law, Lucy Carter, Rachel Sellers, Richard Emsley, Melissa Pyle, Paul French, David Shiers, Alison R Yung, Elizabeth K Murphy, Natasha Holden, Ann Steele, Samantha E Bowe, Jasper Palmier-Claus, Victoria Brooks, Rory Byrne, Linda Davies, Peter M Haddad
BACKGROUND: Little evidence is available for head-to-head comparisons of psychosocial interventions and pharmacological interventions in psychosis. We aimed to establish whether a randomised controlled trial of cognitive behavioural therapy (CBT) versus antipsychotic drugs versus a combination of both would be feasible in people with psychosis. METHODS: We did a single-site, single-blind pilot randomised controlled trial in people with psychosis who used services in National Health Service trusts across Greater Manchester, UK...
March 28, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29600032/the-enigma-of-the-weekend-effect
#7
EDITORIAL
Anoop Mathew, Saad Ahmed Fyyaz, Paul Richard Carter, Rahul Potluri
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29599548/worldwide-engagement-for-digitizing-biocollections-wedigbio-the-biocollections-community-s-citizen-science-space-on-the-calendar
#8
Elizabeth R Ellwood, Paul Kimberly, Robert Guralnick, Paul Flemons, Kevin Love, Shari Ellis, Julie M Allen, Jason H Best, Richard Carter, Simon Chagnoux, Robert Costello, Michael W Denslow, Betty A Dunckel, Meghan M Ferriter, Edward E Gilbert, Christine Goforth, Quentin Groom, Erica R Krimmel, Raphael LaFrance, Joann Lacey Martinec, Andrew N Miller, Jamie Minnaert-Grote, Thomas Nash, Peter Oboyski, Deborah L Paul, Katelin D Pearson, N Dean Pentcheff, Mari A Roberts, Carrie E Seltzer, Pamela S Soltis, Rhiannon Stephens, Patrick W Sweeney, Matt von Konrat, Adam Wall, Regina Wetzer, Charles Zimmerman, Austin R Mast
The digitization of biocollections is a critical task with direct implications for the global community who use the data for research and education. Recent innovations to involve citizen scientists in digitization increase awareness of the value of biodiversity specimens; advance science, technology, engineering, and math literacy; and build sustainability for digitization. In support of these activities, we launched the first global citizen-science event focused on the digitization of biodiversity specimens: Worldwide Engagement for Digitizing Biocollections (WeDigBio)...
February 1, 2018: Bioscience
https://www.readbyqxmd.com/read/29595147/measuring-the-effective-area-and-charge-density-of-platinum-electrodes-for-bionic-devices
#9
Alex Harris, Carrie Newbold, Paul Carter, Robert Cowan, Gordon G Wallace
OBJECTIVE: Neural stimulation is usually performed with fairly large platinum electrodes. Smaller electrodes increase the applied charge density, potentially damaging the electrode. Greater understanding of the charge injection mechanism is required for safe neural stimulation. APPROACH: The charge injection mechanism and charge injection capacity were measured by cyclic voltammetry. Electrodes were cleaned mechanically or by potential cycling in acidic solutions...
March 29, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29588851/vancomycin-resistant-enterococcus-faecium-sequence-type-796-rapid-international-dissemination-of-a-new-epidemic-clone
#10
Andrew A Mahony, Andrew H Buultjens, Susan A Ballard, Elizabeth A Grabsch, Shirley Xie, Torsten Seemann, Rhonda L Stuart, Despina Kotsanas, Allen Cheng, Helen Heffernan, Sally A Roberts, Geoffrey W Coombs, Narin Bak, John K Ferguson, Glen C Carter, Benjamin P Howden, Timothy P Stinear, Paul D R Johnson
Background: Vancomycin-resistant Enterococcus faecium (VRE) is a leading cause of hospital-acquired infections. New, presumably better-adapted strains of VRE appear unpredictably; it is uncertain how they spread despite improved infection control. We aimed to investigate the relatedness of a novel sequence type (ST) of vanB E. faecium - ST796 - very near its time of origin from hospitals in three Australian states and New Zealand. Methods: Following near-simultaneous outbreaks of ST796 in multiple institutions, we gathered then tested colonization and bloodstream infection isolates' antimicrobial resistance (AMR) phenotypes, and phylogenomic relationships using whole genome sequencing (WGS)...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29563534/analysis-of-long-term-study-indicates-both-agronomic-optimal-plant-density-and-increase-maize-yield-per-plant-contributed-to-yield-gain
#11
Yared Assefa, Paul Carter, Mark Hinds, Gaurav Bhalla, Ryan Schon, Mark Jeschke, Steve Paszkiewicz, Stephen Smith, Ignacio A Ciampitti
Concurrent to yield, maize (Zea Mays L.) plant density has significantly increased over the years. Unlike yield, however, the rate of change in plant density and its contribution to maize yield gain are rarely reported. The main objectives of this study were to examine the trend in the agronomic optimum plant density (AOPD) and quantify the contribution of plant density to yield gain. Maize hybrid by seeding rate trials were conducted from 1987-2016 across North America (187,662 data points). Mixed model, response surface, and simple linear regression analyses were applied on the meta-data...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535011/translation-of-knowledge-to-practice-improving-awareness-in-nsclc-molecular-testing
#12
Alona Zer, Jean Claude Cutz, Harman Sekhon, David M Hwang, Christina Sit, Manjula Maganti, Mike Sung, Matthew Binnie, Anthony Brade, Tae Bong Chung, Suzanne Kamel-Reid, Paul Narinder, Ming S Tsao, Tom Waddell, Gilda da Cunha Santos, Milan Patel, Ron F Carter, Natasha B Leighl
BACKGROUND: Molecular testing in advanced lung cancer is standard in guiding treatment selection. However, population-wide implementation of testing remains a challenge. We developed a knowledge translation intervention to improve understanding among diagnostic specialists about molecular testing and appropriate diagnostic sampling in lung cancer. METHODS: Specialty-specific education programs were developed from existing literature and input from Canadian leaders in lung pathology, respirology, interventional radiology, thoracic surgery, radiation and medical oncology...
March 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29534694/predicting-the-severity-of-dengue-fever-in-children-on-admission-based-on-clinical-features-and-laboratory-indicators-application-of-classification-tree-analysis
#13
Khansoudaphone Phakhounthong, Pimwadee Chaovalit, Podjanee Jittamala, Stuart D Blacksell, Michael J Carter, Paul Turner, Kheng Chheng, Soeung Sona, Varun Kumar, Nicholas P J Day, Lisa J White, Wirichada Pan-Ngum
BACKGROUND: Dengue fever is a re-emerging viral disease commonly occurring in tropical and subtropical areas. The clinical features and abnormal laboratory test results of dengue infection are similar to those of other febrile illnesses; hence, its accurate and timely diagnosis for providing appropriate treatment is difficult. Delayed diagnosis may be associated with inappropriate treatment and higher risk of death. Early and correct diagnosis can help improve case management and optimise the use of resources such as hospital staff, beds, and intensive care equipment...
March 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29507048/a-bayesian-framework-for-generalized-linear-mixed-modeling-identifies-new-candidate-loci-for-late-onset-alzheimer-s-disease
#14
Xulong Wang, Vivek M Philip, Guruprasad Ananda, Charles C White, Ankit Malhotra, Paul J Michalski, Krishna R Murthy Karuturi, Sumana R Chintalapudi, Casey Acklin, Michael Sasner, David A Bennett, Philip L De Jager, Gareth R Howell, Gregory W Carter
Recent technical and methodological advances have greatly enhanced genome-wide association studies (GWAS). The advent of low-cost whole-genome sequencing facilitates high-resolution variant identification, and the development of linear mixed models (LMM) allows improved identification of putatively causal variants. While essential for correcting false positive associations due to sample relatedness and population stratification, LMMs have commonly been restricted to quantitative variables. However, phenotypic traits in association studies are often categorical, coded as binary case-control or ordered variables describing disease stages...
March 5, 2018: Genetics
https://www.readbyqxmd.com/read/29474474/lipidomic-analysis-of-immune-activation-in-equine-leptospirosis-and-leptospira-vaccinated-horses
#15
Paul L Wood, Margaret Steinman, Erdal Erol, Craig Carter, Undine Christmann, Ashutosh Verma
Currently available diagnostic assays for leptospirosis cannot differentiate vaccine from infection serum antibody. Several leptospiral proteins that are upregulated during infection have been described, but their utility as a diagnostic marker is still unclear. In this study, we undertook a lipidomics approach to determine if there are any differences in the serum lipid profiles of horses naturally infected with pathogenic Leptospira spp. and horses vaccinated against a commercially available bacterin. Utilizing a high-resolution mass spectrometry serum lipidomics analytical platform, we demonstrate that cyclic phosphatidic acids, diacylglycerols, and hydroperoxide oxidation products of choline plasmalogens are elevated in the serum of naturally infected as well as vaccinated horses...
2018: PloS One
https://www.readbyqxmd.com/read/29443490/orthogonally-aligned-block-copolymer-line-patterns-on-minimal-topographic-patterns
#16
Jaewon Choi, Yinyong Li, Paul Y Kim, Feng Liu, Hyeyoung Kim, Duk Man Yu, June Huh, Kenneth R Carter, Thomas P Russell
We demonstrate the generation of block copolymer (BCP) line patterns oriented orthogonal to a very small (minimal) topographic trench pattern over arbitrarily large areas using solvent vapor annealing (SVA). Increasing the thickness of BCP films induced an orthogonal alignment of the BCP cylindrical microdomains, where full orthogonal alignment of the cylindrical microdomains with respect to the trench direction was obtained at a film thickness of corresponding to 1.70L0. A capillary flow of the solvent across the trenches could be attributed to a critical factor in the alignment of the cylindrical microdomains...
February 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29399393/pd-1-blockade-reverses-adaptive-immune-resistance-induced-by-high-dose-hypofractionated-but-not-low-dose-daily-fractionated-radiation
#17
Megan Morisada, Paul E Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W Hodge, James B Mitchell, Jay Friedman, Clint T Allen
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR used for many tumor types including head and neck squamous cell carcinoma results in lymphopenia and may be immunosuppressive. We compared immune correlates, primary tumor and abscopal tumor control rates following the addition of PD-1 mAb to either high-dose hypofractioned (8Gyx2) or low-dose daily fractionated (2Gyx10) IR in syngeneic models of cancer...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#18
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29346766/cell-type-specificity-of-callosally-evoked-excitation-and-feedforward-inhibition-in-the-prefrontal-cortex
#19
Paul G Anastasiades, Joseph J Marlin, Adam G Carter
Excitation and inhibition are highly specific in the cortex, with distinct synaptic connections made onto subtypes of projection neurons. The functional consequences of this selective connectivity depend on both synaptic strength and the intrinsic properties of targeted neurons but remain poorly understood. Here, we examine responses to callosal inputs at cortico-cortical (CC) and cortico-thalamic (CT) neurons in layer 5 of mouse prelimbic prefrontal cortex (PFC). We find callosally evoked excitation and feedforward inhibition are much stronger at CT neurons compared to neighboring CC neurons...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29341587/fucoidan-prolongs-the-circulation-time-of-dextran-coated-iron-oxide-nanoparticles
#20
Maha R A Abdollah, Thomas J Carter, Clare Jones, Tammy L Kalber, Vineeth Rajkumar, Berend Tolner, Cordula Gruettner, May Zaw-Thin, Julia Baguña Torres, Matthew Ellis, Mathew Robson, R Barbara Pedley, Paul Mulholland, Rafael T M de Rosales, Kerry Ann Chester
The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated research on applications for SPIONs in particle imaging and magnetic hyperthermia. The wider clinical potential of SPIONs, however, has been limited by their rapid removal from circulation via the reticuloendothelial system (RES). We explored the possibility of extending SPION circulatory time using fucoidan, a seaweed-derived food supplement, to inhibit RES uptake...
January 17, 2018: ACS Nano
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