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Paul Carter

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https://www.readbyqxmd.com/read/28228196/the-hidden-story-of-innovation-charity-hospital-angola-prison-and-the-challenging-of-surgical-dogma
#1
Patrick Greiffenstein, Paul R Hastings
The late 1960s was a period of significant upheaval of social, cultural, and scientific norms. The generally accepted notion of mandatory laparotomy for all penetrating abdominal injuries was among those norms being called into question across the country and many advocated expectant management of selected patients presenting with this type of injury. Leaders of the surgical community published opinions on either side of the argument. The house staff at Charity Hospital during this period was among the busiest in the nation in treating these injuries, many of them inmates of the Louisiana State Penitentiary who used self-inflicted stab wounds to the abdomen as a means of temporary respite from the inhumane conditions in the prison...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28227691/understanding-the-cochlear-implant-environment-by-mapping-perilymph-proteomes-from-different-species
#2
Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green, Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green, Ya Lang Enke, Rylie A Green, Jonathan C Palmer, Nigel H Lovell, Paul M Carter, Jeremy L Pinyon, Gary D Housley, Andrew K Wise, Megan S Lord
Cochlear implants operate within a bony channel of the cochlea, bathed in a fluid known as the perilymph. The perilymph is a complex fluid containing ions and proteins, which are known to actively interact with metallic electrodes. To improve our understanding of how cochlear implant performance varies in preclinical in vivo studies in comparison to human trials and patient outcomes, the protein composition (or perilymph proteome) is needed. Samples of perilymph were gathered from feline and guinea pig subjects and analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS) to produce proteomes and compare against the recently published human proteome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28209138/using-whole-genome-sequencing-to-investigate-transmission-in-a-multi-host-system-bovine-tuberculosis-in-new-zealand
#3
Joseph Crispell, Ruth N Zadoks, Simon R Harris, Brent Paterson, Desmond M Collins, Geoffrey W de-Lisle, Paul Livingstone, Mark A Neill, Roman Biek, Samantha J Lycett, Rowland R Kao, Marian Price-Carter
BACKGROUND: Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is an important livestock disease raising public health and economic concerns around the world. In New Zealand, a number of wildlife species are implicated in the spread and persistence of bTB in cattle populations, most notably the brushtail possum (Trichosurus vulpecula). Whole Genome Sequenced (WGS) M. bovis isolates sourced from infected cattle and wildlife across New Zealand were analysed. Bayesian phylogenetic analyses were conducted to estimate the substitution rate of the sampled population and investigate the role of wildlife...
February 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28203622/a-case-of-eczema-coxsackium-with-erythema-multiforme-like-histopathology-in-a-14-year-old-boy-with-chronic-graft-versus-host-disease
#4
Patricia K Miller, Muhammad Zain-Ul-Abideen, Joan Paul, Ann E Perry, Konstantinos Linos, Joi B Carter, Joanne Kurtzberg, Julianne A Mann
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28197597/the-effect-of-sodium-species-on-methanol-synthesis-and-water-gas-shift-cu-zno-catalysts-utilising-high-purity-zincian-georgeite
#5
Simon A Kondrat, Paul J Smith, James H Carter, James S Hayward, Geoffrey J Pudge, Greg Shaw, Michael S Spencer, Jonathan K Bartley, Stuart H Taylor, Graham J Hutchings
The effect of sodium species on the physical and catalytic properties of Cu/ZnO catalysts derived from zincian georgeite has been investigated. Catalysts prepared with <100 ppm to 2.1 wt% Na(+), using a supercritical CO2 antisolvent technique, were characterised and tested for the low temperature water-gas shift reaction and also CO2 hydrogenation to methanol. It was found that zincian georgeite catalyst precursor stability was dependent on the Na(+) concentration, with the 2.1 wt% Na(+)-containing sample uncontrollably ageing to malachite and sodium zinc carbonate...
February 15, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28193052/characterization-of-chain-pairing-variants-of-bispecific-igg-expressed-in-a-single-host-cell-by-high-resolution-native-and-denaturing-mass-spectrometry
#6
Luis Schachner, Guanghui Han, Michael Dillon, Jianhui Zhou, Luke McCarty, Diego Ellerman, Yiyuan Yin, Christoph Spiess, Jennie R Lill, Paul J Carter, Wendy Sandoval
Bispecific antibodies, including bispecific IgG, show some promise in clinical trials as a means to extend the therapeutic potential of antibodies. Bispecific IgG can be made by separate expression and purification of each parent half antibody followed by in vitro reconstitution. Generating bispecific IgG by coexpression of two different light and heavy chains in a single host cell is potentially more efficient because it obviates the need for two separate cell lines and purification processes. However, this workflow may produce unwanted mispaired IgG species in addition to the desired bispecific IgG...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28176305/what-is-the-impact-of-preconception-abdominal-cerclage-on-fertility-evidence-from-a-randomized-controlled-trial
#7
Nicola J Vousden, Jenny Carter, Paul T Seed, Andrew H Shennan
INTRODUCTION: There is documented concern that cerclage may cause cervical stenosis or changes to the cervical mucus, which may reduce fertility. The aim of this study is to determine whether placement of a preconception abdominal cerclage affects fertility. MATERIAL AND METHODS: This was a planned subgroup analysis of a randomized controlled trial comparing abdominal cerclage, high vaginal or low vaginal cerclage. Women with a history of previous second trimester miscarriage or preterm birth despite having a low vaginal cerclage, presenting to specialist preterm birth services in the UK, were eligible for inclusion...
February 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28170043/germline-and-somatic-bap1-mutations-in-high-grade-rhabdoid-meningiomas
#8
Ganesh M Shankar, Malak Abedalthagafi, Rachael A Vaubel, Parker H Merrill, Naema Nayyar, Corey M Gill, Ryan Brewster, Wenya Linda Bi, Pankaj K Agarwalla, Aaron R Thorner, David A Reardon, Ossama Al-Mefty, Patrick Y Wen, Brian M Alexander, Paul van Hummelen, Tracy T Batchelor, Keith L Ligon, Azra H Ligon, Matthew Meyerson, Ian F Dunn, Rameen Beroukhim, David N Louis, Arie Perry, Scott L Carter, Caterina Giannini, William T Curry, Daniel P Cahill, Frederick G Barker, Priscilla K Brastianos, Sandro Santagata
No abstract text is available yet for this article.
November 9, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28140345/ultrathin-transparent-membranes-for-cellular-barrier-and-co-culture-models
#9
Robert N Carter, Stephanie M Casillo, Andrea R Mazzocchi, Jon-Paul S DesOrmeaux, James A Roussie, Thomas R Gaborski
Typical in vitro barrier and co-culture models rely upon thick semi-permeable polymeric membranes that physically separate two compartments. Polymeric track-etched membranes, while permeable to small molecules, are far from physiological with respect to physical interactions with co-cultured cells and are not compatible with high-resolution imaging due to light scattering and autofluorescence. Here we report on an optically transparent ultrathin membrane with porosity exceeding 20%. We optimize deposition and annealing conditions to create a tensile and robust porous silicon dioxide membrane that is comparable in thickness to the vascular basement membrane (100-300 nm)...
February 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/28138040/comparative-effects-of-ly3020371-a-potent-and-selective-mglu2-3-receptor-antagonist-and-ketamine-a-non-competitive-nmda-receptor-antagonist-in-rodents-evidence-supporting-use-for-the-treatment-of-depression
#10
Jeffrey M Witkin, Stephen Mitchell, Keith Wafford, Guy Carter, Gary Gilmour, Jennifer Li, Brian Eastwood, Carl Overshiner, Xia Li, Linda Rorick-Kehn, Kurt Rasmussen, Wesley Anderson, Alexander Nikolayev, Vladamir Tolstikov, Ming-Shang Kuo, John Catlow, Renhua Li, Stephen Smith, Charles Mitch, Paul Ornstein, Stephen Swanson, James Monn
The ability of the NMDA receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment resistant depression (TRD) is well documented. In this report, we directly compare in vivo biological responses in rodents elicited by a recently discovered mGlu2/3 receptor antagonist (LY3020371) with those produced by ketamine. Both LY3020371 and ketamine increased the number of spontaneously active DA cells in the ventral tegmental area of anesthetized rats, increased O2 in the anterior cingulate cortex, promoted wakefulness, enhanced the efflux of biogenic amines in the prefrontal cortex, and produced antidepressant-related behavioral effects in SSRI-sensitive and -insensitive rodent models...
January 30, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28131446/human-exposure-assessment-of-different-arsenic-species-in-household-water-sources-in-a-high-risk-arsenic-area
#11
Hifza Rasheed, Paul Kay, Rebecca Slack, Yun Yun Gong, Annie Carter
Understanding arsenic speciation in water is important for managing the potential health risks associated with chronic arsenic exposure. Most arsenic monitoring studies to date have only measured total arsenic, with few looking at arsenic species. This study assessed 228 ground water sources in six unstudied villages in Pakistan for total, inorganic and organic arsenic species using ion chromatography inductively coupled plasma collision reaction cell mass spectrometry. The concentration levels approached 3090μgL(-1) (95% CI, 130...
January 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28097748/schinortriterpenoids-a-case-study-in-synthetic-design
#12
REVIEW
Xin Li, Paul Ha-Yeon Cheong, Rich G Carter
Since the pioneering days of total synthesis and retrosynthetic analysis, the community has embraced guiding principles for planning synthetic approaches towards complex natural products. These guideposts have enabled the community to synthesize ever more complex compounds by applying prior knowledge gained in new settings. The recently isolated schinortriterpenoid family of natural products has attracted considerable synthetic attention and provided a rich opportunity to evaluate the lessons learned in the construction of complex, polycyclic scaffolds...
January 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28090732/high-engagement-high-quality-a-guiding-framework-for-developing-empirically-informed-asynchronous-e-learning-programs-for-health-professional-educators
#13
Peter M Sinclair, Tracey Levett-Jones, Amanda Morris, Ben Carter, Paul N Bennett, Ashley Kable
E-learning involves the transfer of skills and knowledge via technology so that learners can access meaningful and authentic educational materials. While learner engagement is important, in the context of healthcare education, pedagogy must not be sacrificed for edu-tainment style instructional design. Consequently, health professional educators need to be competent in the use of current web-based educational technologies so that learners are able to access relevant and engaging e-learning materials without restriction...
January 16, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/28077246/testing-of-a-palatable-bait-and-compatible-vaccine-carrier-for-the-oral-vaccination-of-european-badgers-meles-meles-against-tuberculosis
#14
Sonya Gowtage, Gareth A Williams, Ray Henderson, Paul Aylett, Duncan MacMorran, Si Palmer, Andy Robertson, Sandrine Lesellier, Stephen P Carter, Mark A Chambers
The oral vaccination of wild badgers (Meles meles) with live Bacillus Calmette-Guérin (BCG) is one of the tools being considered for the control of bovine tuberculosis (caused by Mycobacterium bovis) in the UK. The design of a product for oral vaccination requires that numerous, and often competing, conditions are met. These include the need for a highly palatable, but physically stable bait that will meet regulatory requirements, and one which is also compatible with the vaccine formulation; in this case live BCG...
January 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28062796/integrated-cellular-and-plasma-proteomics-of-contrasting-b-cell-cancers-reveals-common-unique-and-systemic-signatures
#15
Harvey E Johnston, Matthew J Carter, Kerry L Cox, Melanie Dunscombe, Antigoni Manousopoulou, Paul A Townsend, Spiro D Garbis, Mark S Cragg
Approximately 800,000 leukaemia and lymphoma cases are diagnosed worldwide each year. Burkitt's lymphoma (BL) and chronic lymphocytic leukaemia (CLL), are examples of contrasting B-cell cancers; BL is a highly aggressive lymphoid tumour, frequently affecting children, whilst CLL typically presents as an indolent, slow-progressing leukaemia affecting the elderly. The B-cell-specific over-expression of the myc and tcl1 oncogenes in mice induce spontaneous malignancies modelling BL and CLL, respectively. Quantitative mass spectrometry proteomics and isobaric labelling were employed to examine the biology underpinning contrasting Eμ-myc and Eμ-TCL1 B-cell tumours...
January 4, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28013205/clinical-correlates-of-faecal-incontinence-in-systemic-sclerosis-identifying-therapeutic-avenues
#16
Nicolas Richard, Marie Hudson, Geneviève Gyger, Murray Baron, Evelyn Sutton, Nader Khalidi, Janet E Pope, Nathalie Carrier, Maggie Larché, Alexandra Albert, Paul R Fortin, Carter Thorne, Ariel Masetto
OBJECTIVES: The aim was to establish the prevalence and severity of faecal incontinence (FI) in SSc, its association with other intestinal manifestations and potential predictors of FI, and its impact on quality of life. METHODS: A multicentre, cross-sectional study of 298 SSc subjects followed in the Canadian Scleroderma Research Group cohort was performed using validated questionnaires: Jorge-Wexner score (an FI severity scale), Bristol stool scale (a visual scale of stool consistency) and FI Quality-of-Life scale...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/27931935/behaviour-of-european-badgers-and-non-target-species-towards-candidate-baits-for-oral-delivery-of-a-tuberculosis-vaccine
#17
Andrew Robertson, Richard J Delahay, Robbie A McDonald, Paul Aylett, Ray Henderson, Sonya Gowtage, Mark A Chambers, Stephen P Carter
In the UK and the Republic of Ireland, the European badger (Meles meles) is a maintenance host for Mycobacterium bovis, and may transmit the infection to cattle causing bovine tuberculosis (TB). Vaccination of badgers using an injectable Bacillus Calmette-Guerin (BCG) vaccine is undertaken in some areas of the UK with the intention of interrupting this transmission, and vaccination research is underway in Ireland. An oral badger TB vaccine is also under development. We investigated the behaviour of badgers and non-target wildlife species towards three candidate baits being considered for delivering BCG to badgers orally...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27930278/for-love-not-money-the-financial-implications-of-surgical-fellowship-training
#18
Paul M Inclan, Adam S Hyde, Michael Hulme, Jeffrey E Carter
Surgical residents cite increased income potential as a motivation for pursuing fellowship training, despite little evidence supporting this perception. Thus, our goal is to quantify the financial impact of surgical fellowship training on financial career value. By using Medical Group Management Association and Association of American Medical Colleges physician income data, and accounting for resident salary, student debt, a progressive tax structure, and forgone wages associated with prolonged training, we generated a net present value (NPV) for both generalist and subspecialist surgeons...
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27929752/efficient-production-of-bispecific-igg-of-different-isotypes-and-species-of-origin-in-single-mammalian-cells
#19
Michael Dillon, Yiyuan Yin, Jianhui Zhou, Luke McCarty, Diego Ellerman, Dionysos Slaga, Teemu T Junttila, Guanghui Han, Wendy Sandoval, Meric A Ovacik, Kedan Lin, Zhilan Hu, Amy Shen, Jacob E Corn, Christoph Spiess, Paul J Carter
Bispecific IgG production in single host cells has been a much sought-after goal to support the clinical development of these complex molecules. Current routes to single cell production of bispecific IgG include engineering heavy chains for heterodimerization and redesign of Fab arms for selective pairing of cognate heavy and light chains. Here, we describe novel designs to facilitate selective Fab arm assembly in conjunction with previously described knobs-into-holes mutations for preferential heavy chain heterodimerization...
February 2017: MAbs
https://www.readbyqxmd.com/read/27925665/viral-oncoprotein-antibodies-as-a-marker-for-recurrence-of-merkel-cell-carcinoma-a-prospective-validation-study
#20
Kelly G Paulson, Christopher W Lewis, Mary W Redman, William T Simonson, Aaron Lisberg, Deborah Ritter, Chihiro Morishima, Kathleen Hutchinson, Lola Mudgistratova, Astrid Blom, Jayasri Iyer, Ata S Moshiri, Erica S Tarabadkar, Joseph J Carter, Shailender Bhatia, Masaoki Kawasumi, Denise A Galloway, Mark H Wener, Paul Nghiem
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antigens) have been correlated with MCC tumor burden. The present study assesses the clinical utility of MCPyV-oncoprotein antibody titers for MCC prognostication and surveillance. METHODS: MCPyV-oncoprotein antibody detection was optimized in a clinical laboratory...
December 7, 2016: Cancer
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