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Paul Carter

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https://www.readbyqxmd.com/read/27909094/a-case-of-exertional-rhabdomyolysis-a-cheer-for-standardizing-inpatient-management-and-prevention
#1
Youyang Yang, Lindsay P Carter, Rebecca E Cook, Elahna Paul, Kevin R Schwartz
No abstract text is available yet for this article.
December 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27900369/genomic-profiling-of-multiple-sequentially-acquired-tumor-metastatic-sites-from-an-exceptional-responder-lung-adenocarcinoma-patient-reveals-extensive-genomic-heterogeneity-and-novel-somatic-variants-driving-treatment-response
#2
Romi Biswas, Shaojian Gao, Constance M Cultraro, Tapan K Maity, Abhilash Venugopalan, Zied Abdullaev, Alexey K Shaytan, Corey A Carter, Anish Thomas, Arun Rajan, Young Song, Stephanie Pitts, Kevin Chen, Sara Bass, Joseph Boland, Ken-Ichi Hanada, Jinqiu Chen, Paul S Meltzer, Anna R Panchenko, James C Yang, Svetlana Pack, Giuseppe Giaccone, David S Schrump, Javed Khan, Udayan Guha
We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an "exceptional responder" lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alterations of the lung and lymph nodes. One novel translocation, PLAG1-ACTA2, present in both sites, up-regulated ACTA2 expression. ERBB2, the predominant driver oncogene, was amplified in both sites, more pronounced in the lung, and harbored an L869R mutation in the lymph node...
November 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27899157/disorders-of-sex-development-insights-from-targeted-gene-sequencing-of-a-large-international-patient-cohort
#3
Stefanie Eggers, Simon Sadedin, Jocelyn A van den Bergen, Gorjana Robevska, Thomas Ohnesorg, Jacqueline Hewitt, Luke Lambeth, Aurore Bouty, Ingrid M Knarston, Tiong Yang Tan, Fergus Cameron, George Werther, John Hutson, Michele O'Connell, Sonia R Grover, Yves Heloury, Margaret Zacharin, Philip Bergman, Chris Kimber, Justin Brown, Nathalie Webb, Matthew F Hunter, Shubha Srinivasan, Angela Titmuss, Charles F Verge, David Mowat, Grahame Smith, Janine Smith, Lisa Ewans, Carolyn Shalhoub, Patricia Crock, Chris Cowell, Gary M Leong, Makato Ono, Antony R Lafferty, Tony Huynh, Uma Visser, Catherine S Choong, Fiona McKenzie, Nicholas Pachter, Elizabeth M Thompson, Jennifer Couper, Anne Baxendale, Jozef Gecz, Benjamin J Wheeler, Craig Jefferies, Karen MacKenzie, Paul Hofman, Philippa Carter, Richard I King, Csilla Krausz, Conny M A van Ravenswaaij-Arts, Leendert Looijenga, Sten Drop, Stefan Riedl, Martine Cools, Angelika Dawson, Achmad Zulfa Juniarto, Vaman Khadilkar, Anuradha Khadilkar, Vijayalakshmi Bhatia, Vũ Chí Dũng, Irum Atta, Jamal Raza, Nguyen Thi Diem Chi, Tran Kiem Hao, Vincent Harley, Peter Koopman, Garry Warne, Sultana Faradz, Alicia Oshlack, Katie L Ayers, Andrew H Sinclair
BACKGROUND: Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often difficult and currently only 13% of patients receive an accurate clinical genetic diagnosis. To address this we have developed a massively parallel sequencing targeted DSD gene panel which allows us to sequence all 64 known diagnostic DSD genes and candidate genes simultaneously. RESULTS: We analyzed DNA from the largest reported international cohort of patients with DSD (278 patients with 46,XY DSD and 48 with 46,XX DSD)...
November 29, 2016: Genome Biology
https://www.readbyqxmd.com/read/27899042/hepatic-rhythmicity-of-endoplasmic-reticulum-stress-is-disrupted-in-perinatal-and-adult-mice-models-of-high-fat-diet-induced-obesity
#4
Junpei Soeda, Paul Cordero, Jiawei Li, Angelina Mouralidarane, Esra Asilmaz, Shuvra Ray, Vi Nguyen, Rebeca Carter, Marco Novelli, Manlio Vinciguerra, Lucilla Poston, Paul D Taylor, Jude A Oben
We investigated the regulation of hepatic ER stress in healthy liver and adult or perinatally programmed diet-induced non-alcoholic fatty liver disease (NAFLD). Female mice were fed either obesogenic or control diet before mating, during pregnancy and lactation. Post-weaning, offspring from each maternal group were divided into either obesogenic or control diet. At six months, offspring were sacrificed at 4-h intervals over 24 h. Offspring fed obesogenic diets developed NAFLD phenotype, and the combination of maternal and offspring obesogenic diets exacerbated this phenotype...
November 29, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27821498/established-t-cell-inflamed-tumors-rejected-after-adaptive-resistance-was-reversed-by-combination-sting-activation-and-pd-1-pathway-blockade
#5
Ellen Moore, Paul E Clavijo, Ruth Davis, Harrison Cash, Carter Van Waes, Young Kim, Clint Allen
Patients with head and neck squamous cell carcinoma harbor T cell-inflamed and non-T cell-inflamed tumors. Despite this, only 20% of patients respond to checkpoint inhibitor immunotherapy. Lack of induction of innate immunity through pattern-recognition receptors, such as the stimulator of interferon (IFN) genes (STING) receptor, may represent a significant barrier to the development of effective antitumor immunity. Here, we demonstrate robust control of a T cell-inflamed (MOC1), but not non-T cell-inflamed (MOC2), model of head and neck cancer by activation of the STING pathway with the synthetic cyclic dinucleotide RP,RP dithio-c-di-GMP...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27820605/molecular-level-analysis-of-the-serum-antibody-repertoire-in-young-adults-before-and-after-seasonal-influenza-vaccination
#6
Jiwon Lee, Daniel R Boutz, Veronika Chromikova, M Gordon Joyce, Christopher Vollmers, Kwanyee Leung, Andrew P Horton, Brandon J DeKosky, Chang-Han Lee, Jason J Lavinder, Ellen M Murrin, Constantine Chrysostomou, Kam Hon Hoi, Yaroslav Tsybovsky, Paul V Thomas, Aliaksandr Druz, Baoshan Zhang, Yi Zhang, Lingshu Wang, Wing-Pui Kong, Daechan Park, Lyubov I Popova, Cornelia L Dekker, Mark M Davis, Chalise E Carter, Ted M Ross, Andrew D Ellington, Patrick C Wilson, Edward M Marcotte, John R Mascola, Gregory C Ippolito, Florian Krammer, Stephen R Quake, Peter D Kwong, George Georgiou
Molecular understanding of serological immunity to influenza has been confounded by the complexity of the polyclonal antibody response in humans. Here we used high-resolution proteomics analysis of immunoglobulin (referred to as Ig-seq) coupled with high-throughput sequencing of transcripts encoding B cell receptors (BCR-seq) to quantitatively determine the antibody repertoire at the individual clonotype level in the sera of young adults before and after vaccination with trivalent seasonal influenza vaccine...
November 7, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27806583/performance-of-a-clinical-gridded-electron-gun-in-magnetic-fields-implications-for-mri-linac-therapy
#7
Brendan Whelan, Lois Holloway, Dragos Constantin, Brad Oborn, Magdalena Bazalova-Carter, Rebecca Fahrig, Paul Keall
PURPOSE: MRI-linac therapy is a rapidly growing field, and requires that conventional linear accelerators are operated with the fringe field of MRI magnets. One of the most sensitive accelerator components is the electron gun, which serves as the source of the beam. The purpose of this work was to develop a validated finite element model (FEM) model of a clinical triode (or gridded) electron gun, based on accurate geometric and electrical measurements, and to characterize the performance of this gun in magnetic fields...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27798657/the-met-receptor-tyrosine-kinase-confers-repair-of-murine-pancreatic-acinar-cells-following-acute-and-chronic-injury
#8
Ivana Gaziova, Daniel Jackson, Paul J Boor, Dwayne Carter, Zobeida Cruz-Monserrate, Cornelis J Elferink, Aditya D Joshi, Bhupendra Kaphalia, Craig D Logsdon, Karen Pereira de Castro, Lynn Soong, Xinrong Tao, Suimin Qiu, Lisa A Elferink
Acinar cells represent the primary target in necroinflammatory diseases of the pancreas, including pancreatitis. The signaling pathways guiding acinar cell repair and regeneration following injury remain poorly understood. The purpose of this study was to determine the importance of Hepatocyte Growth Factor Receptor/MET signaling as an intrinsic repair mechanism for acinar cells following acute damage and chronic alcohol-associated injury. Here, we generated mice with targeted deletion of MET in adult acinar cells (MET-/-)...
2016: PloS One
https://www.readbyqxmd.com/read/27781490/dabrafenib-in-brafv600-mutated-anaplastic-pleomorphic-xanthoastrocytoma
#9
Nicholas F Brown, Thomas Carter, Paul Mulholland
Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor. Anaplastic features are found in 20-30% of cases of PXA and are associated with poor outcomes. Typical treatment is with gross total resection, followed by radiation therapy and cytotoxic chemotherapy at relapse. BRAFV600 mutations have been identified in 38-60% of patients with PXA. Several case reports and small case series have identified clinical benefit with BRAF inhibition in patients with BRAFV600-mutated PXA. We report the second published case of successful treatment with the BRAF inhibitor dabrafenib in a female patient with relapsed anaplastic PXA with a BRAFV600 mutation, and the first published case of dabrafinib treatment following intolerance to vemurafenib...
October 26, 2016: CNS Oncology
https://www.readbyqxmd.com/read/27772565/validity-of-the-center-for-epidemiological-studies-depression-scale-in-type-2-diabetes
#10
Jasmine Carter, Hugo Cogo-Moreira, Nathan Herrmann, Daniel Merino, Pearl Yang, Baiju R Shah, Alex Kiss, Jaan Reitav, Paul I Oh, Walter Swardfager
OBJECTIVE: Depressive symptoms are common among people with Type 2 diabetes mellitus (T2DM). This study aimed to validate the 3-factor structure of the 14-item Center for Epidemiological Studies Depression (CES-D) scale proposed by Carleton et al. (2013) in a T2DM population. METHODS: The CES-D was administered to consecutive patients with T2DM entering a rehabilitation program. Construct validity was assessed using confirmatory factor analysis. Subscale viability, differential item functioning, and associations with clinical characteristics were tested in bifactor models...
November 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27758940/ices-intraoperative-stereotactic-computed-tomography-guided-endoscopic-surgery-for-brain-hemorrhage-a-multicenter-randomized-controlled-trial
#11
Paul Vespa, Daniel Hanley, Joshua Betz, Alan Hoffer, Johnathan Engh, Robert Carter, Peter Nakaji, Chris Ogilvy, Jack Jallo, Warren Selman, Amanda Bistran-Hall, Karen Lane, Nichol McBee, Jeffery Saver, Richard E Thompson, Neil Martin
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS: We tested the hypothesis that intraoperative computerized tomographic image-guided endoscopic surgery is safe and effectively removes the majority of the hematoma rapidly...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27734058/safe-drinking-water-in-regional-nsw-australia
#12
Paul M Byleveld, Sandy D Leask, Leslie A Jarvis, Katrina J Wall, Wendy N Henderson, Joshua E Tickell
The New South Wales (NSW) Public Health Act 2010 requires water suppliers to implement a drinking water quality assurance program that addresses the 'Framework for management of drinking water quality' in the Australian drinking water guidelines. NSW Health has recognised the importance of a staged implementation of this requirement and the need to support regional water utilities. To date, NSW Health has assisted 74 regional utilities to develop and implement their management systems. The Public Health Act 2010 has increased awareness of drinking water risk management, and offers a systematic process to identify and control risks...
April 15, 2016: Public Health Research & Practice
https://www.readbyqxmd.com/read/27723799/early-postnatal-lipopolysaccharide-exposure-leads-to-enhanced-neurogenesis-and-impaired-communicative-functions-in-rats
#13
Yi Pang, Xuemei Dai, Anna Roller, Kathleen Carter, Ian Paul, Abhay J Bhatt, Rick C S Lin, Lir-Wan Fan
Perinatal infection is a well-identified risk factor for a number of neurodevelopmental disorders, including brain white matter injury (WMI) and Autism Spectrum Disorders (ASD). The underlying mechanisms by which early life inflammatory events cause aberrant neural, cytoarchitectural, and network organization, remain elusive. This study is aimed to investigate how systemic lipopolysaccharide (LPS)-induced neuroinflammation affects microglia phenotypes and early neural developmental events in rats. We show here that LPS exposure at early postnatal day 3 leads to a robust microglia activation which is characterized with mixed microglial proinflammatory (M1) and anti-inflammatory (M2) phenotypes...
2016: PloS One
https://www.readbyqxmd.com/read/27708246/a-novel-dna-methylation-score-accurately-predicts-death-from-prostate-cancer-in-men-with-low-to-intermediate-clinical-risk-factors
#14
Amar S Ahmad, Nataša Vasiljević, Paul Carter, Daniel M Berney, Henrik Møller, Christopher S Foster, Jack Cuzick, Attila T Lorincz
Clinically aggressive disease behavior is difficult to predict in men with low to intermediate clinical risk prostate cancer and methylation biomarkers may be a valuable adjunct for assessing the management of these patients. We set to evaluate the utility of DNA methylation to identify high risk disease in men currently considered as low or intermediate risk. DNA was extracted from formalin-fixed paraffin-embedded transurethral prostate resection tissues collected during the years 1990-96 in a watchful-waiting cohort of men in the UK...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27704684/cjcheck-stage-1-development-and-testing-of-a-checklist-for-reporting-community-juries-delphi-process-and-analysis-of-studies-published-in-1996-2015
#15
Rae Thomas, Rebecca Sims, Chris Degeling, Jackie M Street, Stacy M Carter, Lucie Rychetnik, Jennifer A Whitty, Andrew Wilson, Paul Ward, Paul Glasziou
BACKGROUND: Opportunities for community members to actively participate in policy development are increasing. Community/citizen's juries (CJs) are a deliberative democratic process aimed to illicit informed community perspectives on difficult topics. But how comprehensive these processes are reported in peer-reviewed literature is unknown. Adequate reporting of methodology enables others to judge process quality, compare outcomes, facilitate critical reflection and potentially repeat a process...
October 5, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/27641470/discovery-of-anabaenopeptin-679-from-freshwater-algal-bloom-material-insights-into-the-structure-activity-relationship-of-anabaenopeptin-protease-inhibitors
#16
Henrik Harms, Kenji L Kurita, Li Pan, Paul G Wahome, Haiyin He, A Douglas Kinghorn, Guy T Carter, Roger G Linington
Cyanobacteria possess a unique capacity for the production of structurally novel secondary metabolites compared to the biosynthetic abilities of other environmental prokaryotes such as bacteria of the genus Streptomyces. Two different strategies to explore cyanobacteria-derived natural products have been explored previously: (1) cultivation of single cyanobacterial strains, in bioreactors for example; (2) bulk collections from the environment of so called 'algal blooms' that are dominated by cyanobacteria. In this study a new environmentally friendly collection technique for obtaining large quantities of algal bloom biomass was utilized...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27620388/research-needs-to-improve-hypertension-treatment-and-control-in-african-americans
#17
Paul K Whelton, Paula T Einhorn, Paul Muntner, Lawrence J Appel, William C Cushman, Ana V Diez Roux, Keith C Ferdinand, Mahboob Rahman, Herman A Taylor, Jamy Ard, Donna K Arnett, Barry L Carter, Barry R Davis, Barry I Freedman, Lisa A Cooper, Richard Cooper, Patrice Desvigne-Nickens, Nara Gavini, Alan S Go, David J Hyman, Paul L Kimmel, Karen L Margolis, Edgar R Miller, Katherine T Mills, George A Mensah, Ann M Navar, Gbenga Ogedegbe, Michael K Rakotz, George Thomas, Jonathan N Tobin, Jackson T Wright, Sung Sug Sarah Yoon, Jeffrey A Cutler
No abstract text is available yet for this article.
November 2016: Hypertension
https://www.readbyqxmd.com/read/27610742/precise-quantification-of-mixtures-of-bispecific-igg-produced-in-single-host-cells-by-liquid-chromatography-orbitrap-high-resolution-mass-spectrometry
#18
Yiyuan Yin, Guanghui Han, Jianhui Zhou, Michael Dillon, Luke McCarty, Lou Gavino, Diego Ellerman, Christoph Spiess, Wendy Sandoval, Paul J Carter
Bispecific IgG are heterotetramers comprising 2 pairs of heavy and light chains. Co-expression of the 4 component chains in a single host cell typically yields the desired bispecific IgG plus up to 9 additional incorrect chain pairings. Several protein engineering strategies have been reported to facilitate the heterodimerization of antibody heavy chains or cognate pairing of antibody heavy and light chains. These technologies have been used to direct the efficient assembly of bispecific IgG in single host cells and minimize unwanted chain pairings...
September 9, 2016: MAbs
https://www.readbyqxmd.com/read/27600181/physician-pharmacist-collaborative-management-narrowing-the-socioeconomic-blood-pressure-gap
#19
Maxwell D Anderegg, Tyler H Gums, Liz Uribe, Christopher S Coffey, Paul A James, Barry L Carter
: Physician-pharmacist collaboration improves blood pressure, but there is little information on whether this model can reduce the gap in healthcare disparities. This trial involved 32 medical offices in 15 states. A clinical pharmacist was embedded within each office and made recommendations to physicians and patients in intervention offices. The purpose of the present analysis was to evaluate whether the pharmacist intervention could reduce healthcare disparities by improving blood pressure in high-risk racial and socioeconomic subjects compared with the control group...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27594820/coinstac-a-privacy-enabled-model-and-prototype-for-leveraging-and-processing-decentralized-brain-imaging-data
#20
Sergey M Plis, Anand D Sarwate, Dylan Wood, Christopher Dieringer, Drew Landis, Cory Reed, Sandeep R Panta, Jessica A Turner, Jody M Shoemaker, Kim W Carter, Paul Thompson, Kent Hutchison, Vince D Calhoun
The field of neuroimaging has embraced the need for sharing and collaboration. Data sharing mandates from public funding agencies and major journal publishers have spurred the development of data repositories and neuroinformatics consortia. However, efficient and effective data sharing still faces several hurdles. For example, open data sharing is on the rise but is not suitable for sensitive data that are not easily shared, such as genetics. Current approaches can be cumbersome (such as negotiating multiple data sharing agreements)...
2016: Frontiers in Neuroscience
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