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Paul Carter

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https://www.readbyqxmd.com/read/28509346/role-of-quantitative-p16-ink4a-mrna-assay-and-digital-reading-of-p16-ink4a-immunostained-sections-in-diagnosis-of-cervical-intraepithelial-neoplasia
#1
Nataša Vasiljević, Paul D Carter, Caroline Reuter, Rhian Warman, Adam R Brentnall, James R Carton, Jack Cuzick, Attila T Lorincz
Visual interpretation of cervical biopsies is subjective and variable, generally showing fair to moderate inter-reader agreement in distinguishing high from low grade cervical intraepithelial neoplasia (CIN). We investigated the performance of two objective p16 quantitative tests in comparison with visual assessment: 1) p16-mRNA assay and 2) digital analysis of sections stained for p16 protein. The primary analysis considered 232 high-risk HPV+ samples from diagnostic cervical specimens. A p16 RT-qPCR (p16-mRNA assay) was run on mRNA extracted from formalin-fixed paraffin-embedded sections...
May 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28490924/improving-molecular-testing-and-personalized-medicine-in-non-small-cell-lung-cancer-in-ontario
#2
C Lim, H S Sekhon, J C Cutz, D M Hwang, S Kamel-Reid, R F Carter, G da Cunha Santos, T Waddell, M Binnie, M Patel, N Paul, T Chung, A Brade, R El-Maraghi, C Sit, M S Tsao, N B Leighl
BACKGROUND: Although molecular testing has become standard in managing advanced nonsquamous non-small-cell lung cancer (nsclc), most patients undergo minimally invasive procedures, and the diagnostic tumour specimens available for testing are usually limited. A knowledge translation initiative to educate diagnostic specialists about sampling techniques and laboratory processes was undertaken to improve the uptake and application of molecular testing in advanced lung cancer. METHODS: A multidisciplinary panel of physician experts including pathologists, respirologists, interventional thoracic radiologists, thoracic surgeons, medical oncologists, and radiation oncologists developed a specialty-specific education program, adapting international clinical guidelines to the local Ontario context...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28485552/effect-of-strontium-citrate-on-bone-consolidation-during-mandibular-distraction-osteogenesis
#3
Benjamin A Taylor, Michael Bezuhly, Matthew Brace, Michael Carter, Paul Hong
OBJECTIVES/HYPOTHESIS: Mandibular distraction osteogenesis (MDO) involves a lengthy consolidation phase where complications can occur. Strontium is an element that has been shown to improve bone healing. The objective of this study was to determine whether strontium citrate can be used to enhance bone healing during MDO in a rabbit model. STUDY DESIGN: Prospective animal model study. METHODS: Custom-made MDO devices were placed on 20 New Zealand White rabbits...
May 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28459459/mapping-the-genomic-landscape-of-crispr-cas9-cleavage
#4
Peter Cameron, Chris K Fuller, Paul D Donohoue, Brittnee N Jones, Matthew S Thompson, Matthew M Carter, Scott Gradia, Bastien Vidal, Elizabeth Garner, Euan M Slorach, Elaine Lau, Lynda M Banh, Alexandra M Lied, Leslie S Edwards, Alexander H Settle, Daniel Capurso, Victor Llaca, Stéphane Deschamps, Mark Cigan, Joshua K Young, Andrew P May
RNA-guided CRISPR-Cas9 endonucleases are widely used for genome engineering, but our understanding of Cas9 specificity remains incomplete. Here, we developed a biochemical method (SITE-Seq), using Cas9 programmed with single-guide RNAs (sgRNAs), to identify the sequence of cut sites within genomic DNA. Cells edited with the same Cas9-sgRNA complexes are then assayed for mutations at each cut site using amplicon sequencing. We used SITE-Seq to examine Cas9 specificity with sgRNAs targeting the human genome. The number of sites identified depended on sgRNA sequence and nuclease concentration...
May 1, 2017: Nature Methods
https://www.readbyqxmd.com/read/28458092/sleep-does-not-cause-false-memories-on-a-story-based-test-of-suggestibility
#5
Elaine van Rijn, Neil Carter, Hazel McMurtrie, Paul Willner, Mark T Blagrove
Sleep contributes to the consolidation of memories. This process may involve extracting the gist of learned material at the expense of details. It has thus been proposed that sleep might lead to false memory formation. Previous research examined the effect of sleep on false memory using the Deese-Roediger-McDermott (DRM) paradigm. Mixed results were found, including increases and decreases in false memory after sleep relative to wake. It has been questioned whether DRM false memories occur by the same processes as real-world false memories...
April 27, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28449286/full-dilatation-cesarean-section-a-risk-factor-for-recurrent-second-trimester-loss-and-preterm-birth
#6
Helena A Watson, Jenny Carter, Anna L David, Paul T Seed, Andrew H Shennan
INTRODUCTION: A previous cesarean section at full dilatation (FDCS) is a risk factor for preterm birth. To provide insight on the risk to subsequent pregnancies, this cohort study compares the outcomes of pregnant women with a previous preterm birth associated either with a prior FDCS or a prior term vaginal delivery. MATERIAL AND METHODS: We identified women attending two inner-city preterm surveillance clinics (Guy's and St Thomas Hospital and University College London Hospital, London, UK) who had a spontaneous late miscarriage (14(+0) -23(+6) weeks) or sPTB (<37weeks) following a term pregnancy, and then a further pregnancy for analysis...
April 27, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28436125/the-quipp-app-a-safe-alternative-to-a-treat-all-strategy-for-threatened-preterm-labour
#7
Helena A Watson, Jenny Carter, Paul T Seed, Rachel M Tribe, Andrew H Shennan
OBJECTIVES: To evaluate the impact of a treat-all policy (advocated by NICE) compared to the QUIPP app (predictive model combining history of spontaneous preterm birth gestation and quantitative fetal fibronectin) for women in threatened preterm labour at <30 weeks gestation. METHODS: We conducted a subanalysis of prospectively collected data of pregnant women presenting with symptoms of preterm labour from the EQUIPP (REC Ref. 10/H0806/68) and PETRA (REC Ref...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28434320/a-good-clonal-response-to-chemotherapy-in-al-amyloidosis-is-associated-with-improved-quality-of-life-and-function-at-1-year
#8
John-Paul Carter, Darren Foard, Lisa Rannigan, Kamela Aliaz, Shameem Mahmood, Sajitha Sachchithanantham, Marianna Fontana, Cristina Quarta, Ana Martinez De Azcona Naharro, Taryn Youngstein, Tamer Rezk, Ashutosh Wechalekar, Carol Whelan, Helen Lachmann, Philip Hawkins, Julian Gillmore, Thirusha Lane
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28426667/bioenergetic-status-modulates-motor-neuron-vulnerability-and-pathogenesis-in-a-zebrafish-model-of-spinal-muscular-atrophy
#9
Penelope J Boyd, Wen-Yo Tu, Hannah K Shorrock, Ewout J N Groen, Roderick N Carter, Rachael A Powis, Sophie R Thomson, Derek Thomson, Laura C Graham, Anna A L Motyl, Thomas M Wishart, J Robin Highley, Nicholas M Morton, Thomas Becker, Catherina G Becker, Paul R Heath, Thomas H Gillingwater
Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor neuron (SMN) protein. One remarkable, yet unresolved, feature of SMA is that not all motor neurons are equally affected, with some populations displaying a robust resistance to the disease. Here, we demonstrate that selective vulnerability of distinct motor neuron pools arises from fundamental modifications to their basal molecular profiles...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28417139/the-fragility-index-a-p-value-in-sheep-s-clothing
#10
Rickey E Carter, Paul M McKie, Curtis B Storlie
No abstract text is available yet for this article.
February 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28388352/health-related-quality-of-life-and-receipt-of-women-centered-hiv-care-among-women-living-with-hiv-in-canada
#11
Allison Carter, Mona Loutfy, Alexandra de Pokomandy, Guillaume Colley, Wendy Zhang, Paul Sereda, Nadia O'Brien, Karène Proulx-Boucher, Valerie Nicholson, Kerrigan Beaver, Angela Kaida
We measured health-related quality of life (HRQOL) using the SF-12 among women living with HIV (WLWH) in Canada between August 2013 and May 2015. We investigated differences by perceived receipt of women-centered HIV care (WCHC), assessed using an evidence-based definition with a 5-point Likert item: "Overall, I think that the care I have received from my HIV clinic in the last year has been women-centered" (dichotomized into agree vs. disagree/neutral). Of 1308 participants, 26.3 percent were from British Columbia, 48...
April 7, 2017: Women & Health
https://www.readbyqxmd.com/read/28381604/a-target-specific-assay-for-rapid-and-quantitative-detection-of-mycobacterium-chimaera-dna
#12
Enrique Zozaya-Valdés, Jessica L Porter, John Coventry, Janet A M Fyfe, Glen P Carter, Anders Gonçalves da Silva, Mark B Schultz, Torsten Seemann, Paul D R Johnson, Andrew J Stewardson, Ivan Bastian, Sally A Roberts, Benjamin P Howden, Deborah A Williamson, Timothy P Stinear
Mycobacterium chimaera is an opportunistic environmental mycobacterium, belonging to the Mycobacterium intracellulare complex. Although most commonly associated with pulmonary disease, there has been growing awareness of invasive M. chimaera infections following cardiac surgery. Investigations suggest world-wide spread of a specific M. chimaera clone, associated with contaminated hospital heater-cooler units used during the surgery. Given the global dissemination of this clone, its potential to cause invasive disease, and the laboriousness of current culture-based diagnostic methods, there is a pressing need to develop rapid and accurate diagnostic assays, specific for M...
April 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28373166/exploring-the-link-between-the-germline-and-somatic-genome-in-cancer
#13
Paul Geeleher, R Stephanie Huang
Carter and colleagues propose a systematic analysis of the germline and somatic genome in cancer. They identify interactions that occur between germline and somatic variants. This elucidates the function of the germline genome in the context of cancer risk and development. Cancer Discov; 7(4); 354-5. ©2017 AACRSee related article by Carter et al., p. 410.
April 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28364629/relations-between-mental-health-diagnoses-mental-health-treatment-and-substance-use-in-homeless-youth
#14
Sarah Carter Narendorf, Matthew B Cross, Diane Santa Maria, Paul R Swank, Patrick S Bordnick
BACKGROUND: Youth experiencing homelessness have elevated rates of mental illness and substance use compared to the general population. However, the extent to which underlying mental health issues may contribute to substance use as a way to manage symptoms and whether mental health treatment may reduce risk for substance use is unclear. This paper investigated these relations in a community sample of homeless youth. METHODS: Youth ages 13-24 (N=416) were interviewed as part of a community count and survey of homeless youth in Houston, Texas...
March 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28364000/anti-pd-l1-efficacy-can-be-enhanced-by-inhibition-of-myeloid-derived-suppressor-cells-with-a-selective-inhibitor-of-pi3k%C3%AE-%C3%AE
#15
Ruth J Davis, Ellen C Moore, Paul E Clavijo, Jay Friedman, Harrison A Cash, Zhong Chen, Christopher Silvin, Carter Van Waes, Clint T Allen
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional inhibition of MDSC with IPI-145, an inhibitor of PI3Kδ and PI3Kγ isoforms which enhances responses to PD-L1 blockade. Combination therapy induced CD8+ T lymphocyte-dependent primary tumor growth delay and prolonged survival only in T cell-inflamed tumor models of head and neck cancers...
March 31, 2017: Cancer Research
https://www.readbyqxmd.com/read/28362186/a-proposal-for-a-new-classification-of-complications-in-craniosynostosis-surgery
#16
Dmitri Shastin, Sharron Peacock, Velu Guruswamy, Melpo Kapetanstrataki, David T Bonthron, Maggie Bellew, Vernon Long, Lachlan Carter, Ian Smith, John Goodden, John Russell, Mark Liddington, Paul Chumas
OBJECTIVE Complications have been used extensively to facilitate evaluation of craniosynostosis practice. However, description of complications tends to be nonstandardized, making comparison difficult. The authors propose a new pragmatic classification of complications that relies on prospective data collection, is geared to capture significant morbidity as well as any "near misses" in a systematic fashion, and can be used as a quality improvement tool. METHODS Data on complications for all patients undergoing surgery for nonsyndromic craniosynostosis between 2010 and 2015 were collected from a prospective craniofacial audit database maintained at the authors' institution...
March 31, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28340606/validating-a-self-report-measure-of-hiv-viral-suppression-an-analysis-of-linked-questionnaire-and-clinical-data-from-the-canadian-hiv-women-s-sexual-and-reproductive-health-cohort-study
#17
MULTICENTER STUDY
Allison Carter, Alexandra de Pokomandy, Mona Loutfy, Erin Ding, Paul Sereda, Kath Webster, Valerie Nicholson, Kerrigan Beaver, Robert S Hogg, Angela Kaida
BACKGROUND: We assessed the validity of a self-report measure of undetectable viral load (VL) among women with HIV in British Columbia (BC), Canada. Questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study was linked with population-based clinical data from the BC Centre for Excellence in HIV/AIDS. Self-reported undetectable VL was assessed by the question: "What was your most recent VL, undetectable (i.e. <50 copies/mL) or detectable (i.e. ≥50 copies/mL)?" Laboratory measurements of VL <50 copies/mL (closest to/before study visit) were the criterion for validity analyses...
March 24, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28281999/the-hidden-story-of-innovation-charity-hospital-angola-prison-and-the-challenging-of-surgical-dogma
#18
Patrick Greiffenstein, Paul R Hastings
The late 1960s was a period of significant upheaval of social, cultural, and scientific norms. The generally accepted notion of mandatory laparotomy for all penetrating abdominal injuries was among those norms being called into question across the country and many advocated expectant management of selected patients presenting with this type of injury. Leaders of the surgical community published opinions on either side of the argument. The house staff at Charity Hospital during this period was among the busiest in the nation in treating these injuries, many of them inmates of the Louisiana State Penitentiary who used self-inflicted stab wounds to the abdomen as a means of temporary respite from the inhumane conditions in the prison...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28269445/understanding-the-cochlear-implant-environment-by-mapping-perilymph-proteomes-from-different-species
#19
Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green
Cochlear implants operate within a bony channel of the cochlea, bathed in a fluid known as the perilymph. The perilymph is a complex fluid containing ions and proteins, which are known to actively interact with metallic electrodes. To improve our understanding of how cochlear implant performance varies in preclinical in vivo studies in comparison to human trials and patient outcomes, the protein composition (or perilymph proteome) is needed. Samples of perilymph were gathered from feline and guinea pig subjects and analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS) to produce proteomes and compare against the recently published human proteome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28247416/heavy-prenatal-alcohol-exposure-is-related-to-smaller-corpus-callosum-in-newborn-mri-scans
#20
Sandra W Jacobson, Joseph L Jacobson, Christopher D Molteno, Christopher M R Warton, Pia Wintermark, H Eugene Hoyme, Greetje De Jong, Paul Taylor, Fleur Warton, Nadine M Lindinger, R Colin Carter, Neil C Dodge, Ellen Grant, Simon K Warfield, Lilla Zöllei, André J W van der Kouwe, Ernesta M Meintjes
BACKGROUND: Magnetic resonance imaging (MRI) studies have consistently demonstrated disproportionately smaller corpus callosa in individuals with a history of prenatal alcohol exposure (PAE) but have not previously examined the feasibility of detecting this effect in infants. Tissue segmentation of the newborn brain is challenging because analysis techniques developed for the adult brain are not directly transferable, and segmentation for cerebral morphometry is difficult in neonates, due to the latter's incomplete myelination...
May 2017: Alcoholism, Clinical and Experimental Research
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