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Paul Carter

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https://www.readbyqxmd.com/read/28814455/national-randomized-controlled-trial-of-virtual-house-calls-for-parkinson-disease
#1
Christopher A Beck, Denise B Beran, Kevin M Biglan, Cynthia M Boyd, E Ray Dorsey, Peter N Schmidt, Richard Simone, Allison W Willis, Nicholas B Galifianakis, Maya Katz, Caroline M Tanner, Kristen Dodenhoff, Jason Aldred, Julie Carter, Andrew Fraser, Joohi Jimenez-Shahed, Christine Hunter, Meredith Spindler, Suzanne Reichwein, Zoltan Mari, Becky Dunlop, John C Morgan, Dedi McLane, Patrick Hickey, Lisa Gauger, Irene Hegeman Richard, Nicte I Mejia, Grace Bwala, Martha Nance, Ludy C Shih, Carlos Singer, Silvia Vargas-Parra, Cindy Zadikoff, Natalia Okon, Andrew Feigin, Jean Ayan, Christina Vaughan, Rajesh Pahwa, Rohit Dhall, Anhar Hassan, Steven DeMello, Sara S Riggare, Paul Wicks, Meredith A Achey, Molly J Elson, Steven Goldenthal, H Tait Keenan, Ryan Korn, Heidi Schwarz, Saloni Sharma, E Anna Stevenson, William Zhu
OBJECTIVE: To determine whether providing remote neurologic care into the homes of people with Parkinson disease (PD) is feasible, beneficial, and valuable. METHODS: In a 1-year randomized controlled trial, we compared usual care to usual care supplemented by 4 virtual visits via video conferencing from a remote specialist into patients' homes. Primary outcome measures were feasibility, as measured by the proportion who completed at least one virtual visit and the proportion of virtual visits completed on time; and efficacy, as measured by the change in the Parkinson's Disease Questionnaire-39, a quality of life scale...
August 16, 2017: Neurology
https://www.readbyqxmd.com/read/28810980/risk-factors-for-rhabdomyolysis-in-the-u-s-army
#2
Owen T Hill, Dennis E Scofield, Jenna Usedom, Lakmini Bulathsinhala, Craig McKinnon, Paul Kwon, Timothy Haley, Robert Carter
The standardized mortality rate of rhabdomyolysis (RM) in Active Duty U.S. Army Soldiers is considerably higher than in the civilian population. RM occurs when large amounts of intracellular contents from damaged skeletal muscle escape into circulation, leading to serious sequelae (e.g., acute renal failure, hyperkalemia, compartment syndrome). Extended physical exertion, especially in hot environments, and trauma can precipitate RM. The aim of this study was to identify RM risk factors among U.S. Active Duty Army (ADA) Soldiers...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28792208/fiber-coupled-substrate-integrated-hollow-waveguides-an-innovative-approach-to-mid-infrared-remote-gas-sensors
#3
Erhan Tütüncü, Vjekoslav Kokoric, Andreas WIlk, Felicia Seichter, Michael Schmid, William E Hunt, Anastacia M Manuel, Paul Mirkarimi, Jennifer B Alameda, J Chance Carter, Boris Mizaikoff
In this study, an innovative approach based on fiberoptically coupled substrate-integrated hollow waveguide (iHWG) gas cells for the analysis of low sample volumes suitable for remote broad- and narrow-band mid-infrared (MIR; 2.5-20 μm) sensing applications is reported. The feasibility of remotely addressing iHWG gas cells, configured in a double-pass geometry via a reflector, by direct coupling to a 7-around-1 mid-infrared fiber bundle is demonstrated, facilitating low-level hydrocarbon gas analysis. For comparison studies, two iHWGs with substrate dimensions of 50×50×12 mm (L × W × H) and geometric channel lengths of 138 mm and 58...
August 9, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28774886/minimally-invasive-and-endoscopic-versus-open-necrosectomy-for-necrotising-pancreatitis-a-pooled-analysis-of-individual-data-for-1980-patients
#4
Sandra van Brunschot, Robbert A Hollemans, Olaf J Bakker, Marc G Besselink, Todd H Baron, Hans G Beger, Marja A Boermeester, Thomas L Bollen, Marco J Bruno, Ross Carter, Jeremy J French, Djalma Coelho, Björn Dahl, Marcel G Dijkgraaf, Nilesh Doctor, Peter J Fagenholz, Gyula Farkas, Carlos Fernandez Del Castillo, Paul Fockens, Martin L Freeman, Timothy B Gardner, Harry van Goor, Hein G Gooszen, Gerjon Hannink, Rajiv Lochan, Colin J McKay, John P Neoptolemos, Atilla Oláh, Rowan W Parks, Miroslav P Peev, Michael Raraty, Bettina Rau, Thomas Rösch, Maroeska Rovers, Hans Seifert, Ajith K Siriwardena, Karen D Horvath, Hjalmar C van Santvoort
OBJECTIVE: Minimally invasive surgical necrosectomy and endoscopic necrosectomy, compared with open necrosectomy, might improve outcomes in necrotising pancreatitis, especially in critically ill patients. Evidence from large comparative studies is lacking. DESIGN: We combined original and newly collected data from 15 published and unpublished patient cohorts (51 hospitals; 8 countries) on pancreatic necrosectomy for necrotising pancreatitis. Death rates were compared in patients undergoing open necrosectomy versus minimally invasive surgical or endoscopic necrosectomy...
August 3, 2017: Gut
https://www.readbyqxmd.com/read/28766476/general-steps-to-standardize-the-laboratory-measurement-of-serum-total-25-hydroxyvitamin-d
#5
Christopher Sempos, Joseph Betz, Johanna Camara, Graham Carter, Etienne Cavalier, Michael Clarke, Kirsten Dowling, Ramon Durazo-Arvizu, Andrew Hoofnagle, Andy Liu, Karen Phinney, Kurtis Sarafin, Stephen Wise, Paul Coates
The Vitamin D Standardization Program (VDSP) has collaborated with numerous groups and agencies to assemble a set of tools, i.e., a reference measurement system, that can be used to establish the traceability of 25-hydroxyvitamin D [25(OH)D] assays to relevant reference measurement procedures and reference materials. This is done with the goal of verifying end-user laboratory performance using precise statistical criteria to determine whether a specific assay is standardized. The purpose of this paper was to outline a set of steps that routine clinical and research laboratories can use to standardize their 25(OH)D assays using these tools...
August 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28727196/insulin-regimens-for-newly-diagnosed-children-with-type-1-diabetes-mellitus-in-australia-and-new-zealand-a-survey-of-current-practice
#6
Dharrshinee Selvakumar, Hesham S Al-Sallami, Martin de Bock, Geoffrey R Ambler, Paul Benitez-Aguirre, Esko Wiltshire, Elaine Tham, Peter Simm, Louise S Conwell, Phillipa J Carter, Benjamin B Albert, Jinny Willis, Benjamin J Wheeler
AIM: There is no consensus on the optimal insulin treatment for children newly diagnosed with type 1 diabetes mellitus (T1DM). The aims of this study were (i) to describe the insulin regimens used at diagnosis by patient age and geographical region and (ii) to explore differences between and within Australia (AU) and New Zealand (NZ) with regards to other aspects of patient management and education. METHODS: An online survey of medical professionals caring for children with T1DM in AU and NZ was undertaken...
July 20, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28723667/resistance-to-ctla-4-checkpoint-inhibition-reversed-through-selective-elimination-of-granulocytic-myeloid-cells
#7
Paul E Clavijo, Ellen C Moore, Jianhong Chen, Ruth J Davis, Jay Friedman, Young Kim, Carter Van Waes, Zhong Chen, Clint T Allen
PURPOSE: Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination on responses to CTLA-4 checkpoint inhibition. EXPERIMENTAL DESIGN: Murine syngeneic carcinoma immune infiltrates were characterized by flow cytometry. Granulocytic MDSCs (gMDSCs) were depleted and T-lymphocyte antigen-specific responses were measured...
June 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722634/cystic-echinococcosis-in-turkana-kenya-the-role-of-cross-sectional-screening-surveys-in-assessing-the-prevalence-of-human-infection
#8
Nadia Solomon, Eberhard Zeyhle, Jane Carter, John Wachira, Asrat Mengiste, Thomas Romig, Paul J Fields, Calum N L Macpherson
Cystic echinococcosis (CE) is a neglected zoonotic disease caused by Echinococcus granulosus. Infection leads to formation of cysts within the viscera of the human host. In the 1980s, the transhumant population of northwest Turkana, Kenya, was found to have the highest prevalence of CE in the world. In 1983, AMREF Health Africa and the Kenya Medical and Research Institute launched a CE Control Program in northwest Turkana, screening and treating the local people. This epidemiological study of CE in Turkana analyses approximately 30 years of surveillance and surgical data...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719151/staged-treatment-in-early-psychosis-a-sequential-multiple-assignment-randomised-trial-of-interventions-for-ultra-high-risk-of-psychosis-patients
#9
REVIEW
Barnaby Nelson, G Paul Amminger, Hok Pan Yuen, Nicky Wallis, Melissa J Kerr, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Sarah Morris, Julie Blasioli, Patrick D McGorry
AIM: Previous research indicates that preventive intervention is likely to benefit patients "at risk" of psychosis, in terms of functional improvement, symptom reduction and delay or prevention of onset of threshold psychotic disorder. The primary aim of the current study is to test outcomes of ultra high risk (UHR) patients, primarily functional outcome, in response to a sequential intervention strategy consisting of support and problem solving (SPS), cognitive-behavioural case management and antidepressant medication...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28706569/supercritical-antisolvent-precipitation-of-amorphous-copper-zinc-georgeite-and-acetate-precursors-for-the-preparation-of-ambient-pressure-water-gas-shift-copper-zinc-oxide-catalysts
#10
Paul J Smith, Simon A Kondrat, James H Carter, Philip A Chater, Jonathan K Bartley, Stuart H Taylor, Michael S Spencer, Graham J Hutchings
A series of copper-zinc acetate and zincian georgeite precursors have been produced by supercritical CO2 antisolvent (SAS) precipitation as precursors to Cu/ZnO catalysts for the water gas shift (WGS) reaction. The amorphous materials were prepared by varying the water/ethanol volumetric ratio in the initial metal acetate solutions. Water addition promoted georgeite formation at the expense of mixed metal acetates, which are formed in the absence of the water co-solvent. Optimum SAS precipitation occurs without water to give high surface areas, whereas high water content gives inferior surface areas and copper-zinc segregation...
May 10, 2017: ChemCatChem
https://www.readbyqxmd.com/read/28704525/rapid-identification-of-genes-controlling-virulence-and-immunity-in-malaria-parasites
#11
Hussein M Abkallo, Axel Martinelli, Megumi Inoue, Abhinay Ramaprasad, Phonepadith Xangsayarath, Jesse Gitaka, Jianxia Tang, Kazuhide Yahata, Augustin Zoungrana, Hayato Mitaka, Arita Acharjee, Partha P Datta, Paul Hunt, Richard Carter, Osamu Kaneko, Ville Mustonen, Christopher J R Illingworth, Arnab Pain, Richard Culleton
Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution. In a proof of principle study, we found that a previously undescribed single nucleotide polymorphism in the binding domain of the erythrocyte binding like protein (EBL) conferred a dramatic change in red blood cell invasion in mutant rodent malaria parasites Plasmodium yoelii...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28689947/a-novel-iliac-morphology-score-predicts-procedural-mortality-and-major-vascular-complications-in-transfemoral-aortic-valve-replacement
#12
Juliet Blakeslee-Carter, David Dexter, Paul Mahoney, Sadie Ahanchi, Samuel Steerman, Sebastian Larion, Brandon Cain, Jean Panneton
OBJECTIVES: Vascular complications remain a significant technical challenge for transfemoral TAVR (Transcatheter Aortic Valve Replacement). The goal of this study was to develop a pre-operative tool for prediction of major vascular complications of TAVR. METHODS: A retrospective review was performed of all patients who underwent transfemoral TAVR at a tertiary medical center from 2011-2015. Iliofemoral arterial measurements were obtained with CTA 3D reconstructions images and an Iliac Morphology Score (IMS) was created from these measurements...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28687669/atrioventricular-nodal-reentrant-tachycardia-in-patients-with-congenital-heart-disease-outcome-after-catheter-ablation
#13
John Papagiannis, Daniel Joseph Beissel, Ulrich Krause, Michel Cabrera, Marta Telishevska, Stephen Seslar, Christopher Johnsrude, Charles Anderson, Svjetlana Tisma-Dupanovic, Diana Connelly, Dimosthenis Avramidis, Christopher Carter, Laszlo Kornyei, Ian Law, Nicholas Von Bergen, Jan Janusek, Jennifer Silva, Eric Rosenthal, Mark Willcox, Peter Kubus, Gabriele Hessling, Thomas Paul
BACKGROUND: The relationship of atrioventricular nodal reentrant tachycardia to congenital heart disease (CHD) and the outcome of catheter ablation in this population have not been studied adequately. METHODS AND RESULTS: A multicenter retrospective study was performed on patients with CHD who had atrioventricular nodal reentrant tachycardia and were treated with catheter ablation. There were 109 patients (61 women), aged 22.1±13.4 years. The majority, 86 of 109 (79%), had CHD resulting in right heart pressure or volume overload...
July 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28683215/monitoring-lung-cancer-screening-utilization-and-outcomes-in-four-cancer-research-network-sites
#14
Michael K Gould, Lori C Sakoda, Debra P Ritzwoller, Michael J Simoff, Christine M Neslund-Dudas, Lawrence H Kushi, Lisa Carter-Harris, Heather Spencer Feigelson, George Minowada, V Paul Doria-Rose
RATIONALE: Lung cancer screening registries can monitor screening outcomes and improve quality of care. OBJECTIVES: To describe nascent lung cancer screening programs and share efficient data collection approaches for mandatory registry reporting in four integrated health care systems of the NCI-funded Cancer Research Network. METHODS: We documented the distinctive characteristics of lung cancer screening programs, provided examples of strategies to facilitate data collection, and described early challenges and possible solutions...
July 6, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28648661/de-novo-epigenetic-programs-inhibit-pd-1-blockade-mediated-t-cell-rejuvenation
#15
Hazem E Ghoneim, Yiping Fan, Ardiana Moustaki, Hossam A Abdelsamed, Pradyot Dash, Pranay Dogra, Robert Carter, Walid Awad, Geoff Neale, Paul G Thomas, Ben Youngblood
Immune-checkpoint-blockade (ICB)-mediated rejuvenation of exhausted T cells has emerged as a promising approach for treating various cancers and chronic infections. However, T cells that become fully exhausted during prolonged antigen exposure remain refractory to ICB-mediated rejuvenation. We report that blocking de novo DNA methylation in activated CD8 T cells allows them to retain their effector functions despite chronic stimulation during a persistent viral infection. Whole-genome bisulfite sequencing of antigen-specific murine CD8 T cells at the effector and exhaustion stages of an immune response identified progressively acquired heritable de novo methylation programs that restrict T cell expansion and clonal diversity during PD-1 blockade treatment...
June 29, 2017: Cell
https://www.readbyqxmd.com/read/28625807/evidence-for-altered-levels-of-igd-in-the-nasal-airway-mucosa-of-patients-with-chronic-rhinosinusitis
#16
Jin-Young Min, Jayakar V Nayak, Kathryn E Hulse, Whitney W Stevens, Paul A Raju, Julia H Huang, Lydia A Suh, Griet A Van Roey, James E Norton, Roderick G Carter, Caroline P E Price, Ava R Weibman, Ali R Rashan, Eliver E Ghosn, Zara M Patel, Tetsuya Homma, David B Conley, Kevin C Welch, Stephanie Shintani-Smith, Anju T Peters, Leslie C Grammer, Kathleen E Harris, Atsushi Kato, Peter H Hwang, Robert C Kern, Leonore A Herzenberg, Robert P Schleimer, Bruce K Tan
BACKGROUND: IgD is an enigmatic antibody isotype best known when coexpressed with IgM on naive B cells. However, increased soluble IgD (sIgD) levels and increased IgD(+)IgM(-) B-cell populations have been described in the human upper respiratory mucosa. OBJECTIVE: We assessed whether levels of sIgD and IgD(+) B cell counts are altered in nasal tissue from patients with chronic rhinosinusitis (CRS). We further characterized IgD(+) B-cell populations and explored clinical and local inflammatory factors associated with tissue sIgD levels...
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28624227/efficient-smn-rescue-following-subcutaneous-tricyclo-dna-antisense-oligonucleotide-treatment
#17
Valérie Robin, Graziella Griffith, John-Paul L Carter, Christian J Leumann, Luis Garcia, Aurélie Goyenvalle
Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of motor neurons. In humans, the severity of the disease is lessened by the presence of a gene copy, SMN2. SMN2 differs from SMN1 by a C-to-T transition in exon 7, which modifies pre-mRNA splicing and prevents successful SMN synthesis. Splice-switching approaches using antisense oligonucleotides (AONs) have already been shown to correct this SMN2 gene transition, providing a therapeutic avenue for SMA...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28621572/changes-to-international-nonproprietary-names-for-antibody-therapeutics-2017-and-beyond-of-mice-men-and-more
#18
Paul W H I Parren, Paul J Carter, Andreas Plückthun
Active pharmaceutical substances require an International Nonproprietary Name (INN) assigned by the World Health Organization (WHO) to obtain market authorization as a medicinal product. INNs are selected to represent a unique, generic name for a drug enabling unambiguous identification by stakeholders worldwide. INNs may be requested after initiating clinical development of an investigational drug. Pharmaceutical classes are indicated by a common stem or suffix. Currently, INNs for monoclonal antibody-based drugs are recognized by the suffix, -mab, preceded by a source infix such as -xi- (chimeric), -zu- (humanized) or -u- (human) designating the species from which the antibody was derived...
August 2017: MAbs
https://www.readbyqxmd.com/read/28607224/evaluation-of-focused-multipolar-stimulation-for-cochlear-implants-a-preclinical-safety-study
#19
Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon
OBJECTIVE: Cochlear implants (CIs) have a limited number of independent stimulation channels due to the highly conductive nature of the fluid-filled cochlea. Attempts to develop highly focused stimulation to improve speech perception in CI users includes the use of simultaneous stimulation via multiple current sources. Focused multipolar (FMP) stimulation is an example of this approach and has been shown to reduce interaction between stimulating channels. However, compared with conventional biphasic current pulses generated from a single current source, FMP is a complex stimulus that includes extended periods of stimulation before charge recovery is achieved, raising questions on whether chronic stimulation with this strategy is safe...
June 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28541707/identification-of-a-potent-selective-and-efficacious-phosphatidylinositol-3-kinase-%C3%AE-pi3k%C3%AE-inhibitor-for-the-treatment-of-immunological-disorders
#20
Qingjie Liu, Qing Shi, David Marcoux, Douglas G Batt, Lyndon Cornelius, Lan-Ying Qin, Zheming Ruan, James Neels, Myra Beaudoin-Bertrand, Anurag S Srivastava, Ling Li, Robert J Cherney, Hua Gong, Scott H Watterson, Carolyn Weigelt, Kathleen M Gillooly, Kim W McIntyre, Jenny H Xie, Mary T Obermeier, Aberra Fura, Bogdan Sleczka, Kevin Stefanski, R M Fancher, Shweta Padmanabhan, Thatipamula Rp, Ipsit Kundu, Kallem Rajareddy, Rodney Smith, James K Hennan, Dezhi Xing, Jingsong Fan, Paul C Levesque, Qian Ruan, Sidney Pitt, Rosemary Zhang, Donna Pedicord, Jie Pan, Melissa Yarde, Hao Lu, Jonathan Lippy, Christine Goldstine, Stacey Skala, Richard A Rampulla, Arvind Mathur, Anuradha Gupta, Pirama Nayagam Arunachalam, John S Sack, Jodi K Muckelbauer, Mary Ellen Cvijic, Luisa M Salter-Cid, Rajeev S Bhide, Michael A Poss, John Hynes, Percy H Carter, John E Macor, Stefan Ruepp, Gary L Schieven, Joseph A Tino
PI3Kδ plays an important role controlling immune cell function and has therefore been identified as a potential target for the treatment of immunological disorders. This article highlights our work toward the identification of a potent, selective, and efficacious PI3Kδ inhibitor. Through careful SAR, the successful replacement of a polar pyrazole group by a simple chloro or trifluoromethyl group led to improved Caco-2 permeability, reduced Caco-2 efflux, reduced hERG PC activity, and increased selectivity profile while maintaining potency in the CD69 hWB assay...
June 22, 2017: Journal of Medicinal Chemistry
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