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Daniel Bromage

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https://www.readbyqxmd.com/read/27353606/outcome-of-1051-octogenarian-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-observational-cohort-from-the-london-heart-attack-group
#1
Daniel I Bromage, Daniel A Jones, Krishnaraj S Rathod, Claire Grout, M Bilal Iqbal, Pitt Lim, Ajay Jain, Sundeep S Kalra, Tom Crake, Zoe Astroulakis, Mick Ozkor, Roby D Rakhit, Charles J Knight, Miles C Dalby, Iqbal S Malik, Anthony Mathur, Simon Redwood, Philip A MacCarthy, Andrew Wragg
BACKGROUND: ST-segment elevation myocardial infarction is increasingly common in octogenarians, and optimal management in this cohort is uncertain. This study aimed to describe the outcomes of octogenarians with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. METHODS AND RESULTS: We analyzed 10 249 consecutive patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention between 2005 and 2011 at 8 tertiary cardiac centers across London, United Kingdom...
June 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26271457/the-pleiotropic-effects-of-metformin-time-for-prospective-studies
#2
Daniel I Bromage, Derek M Yellon
The global prevalence of diabetes has risen to epidemic proportions and the trend is predicted to continue. The consequent burden of cardiovascular morbidity and mortality is a major public health concern and new treatments are required to mitigate the deleterious effects of cardiovascular disease in diabetic patients. Ischaemia-reperfusion injury is well known to exacerbate the harmful effects of acute myocardial infarction and subsequent therapeutic reperfusion, and several mechanical and pharmacological approaches to mitigating this injury have been investigated...
2015: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26038482/time-trend-analyses-of-bleeding-and-mortality-after-primary-percutaneous-coronary-intervention-during-out-of-working-hours-versus-in-working-hours-an-observational-study-of-11%C3%A2-466-patients
#3
COMPARATIVE STUDY
M Bilal Iqbal, Ramzi Khamis, Charles Ilsley, Ghada Mikhail, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Andrew Archbold, Pitt Lim, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Daniel A Jones, Andrew Wragg, Miles Dalby, Phil MacCarthy, Iqbal S Malik
BACKGROUND: Primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment-elevation myocardial infarction. Resources are limited during out of working hours (OWH). Whether PPCI outside working hours is associated with worse outcomes and whether outcomes have improved over time are unknown. METHODS AND RESULTS: We analyzed 11 466 patients undergoing PPCI between 2004 and 2011 at all 8 tertiary cardiac centers in London, United Kingdom...
June 2015: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/25634086/radial-primary-percutaneous-coronary-intervention-is-independently-associated-with-decreased-long-term-mortality-in-high-risk-st-elevation-myocardial-infarction-patients
#4
Krishnaraj S Rathod, Daniel A Jones, Daniel I Bromage, Sean M Gallagher, Vrijraj S Rathod, Simon Kennon, Charles Knight, Martin T Rothman, Anthony Mathur, Elliot Smith, Ajay K Jain, R Andrew Archbold, Andrew Wragg
AIM: To compare long-term clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI) using radial and femoral arterial access. METHODS AND RESULTS: The present study was an observational cohort study of patients with STEMI treated consecutively with PPCI between 2004 and 2011 at a single centre. The primary end point was all-cause mortality at a median follow-up of 3 years.Among 2727 patients, 1600 (58...
March 2015: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/25000249/radial-primary-percutaneous-coronary-intervention-is-independently-associated-with-decreased-long-term-mortality-in-high-risk-st-elevation-myocardial-infarction-patients
#5
Krishnaraj S Rathod, Daniel A Jones, Daniel I Bromage, Sean M Gallagher, Vrijraj S Rathod, Simon Kennon, Charles Knight, Martin T Rothman, Anthony Mathur, Elliot Smith, Ajay K Jain, R Andrew Archbold, Andrew Wragg
AIM: To compare long-term clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI) using radial and femoral arterial access. METHODS AND RESULTS: The present study was an observational cohort study of patients with STEMI treated consecutively with PPCI between 2004 and 2011 at a single centre. The primary end point was all-cause mortality at a median follow-up of 3 years.Among 2727 patients, 1600 (58...
July 3, 2014: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/24704323/stromal-derived-factor-1%C3%AE-a-chemokine-that-delivers-a-two-pronged-defence-of-the-myocardium
#6
REVIEW
Daniel I Bromage, Sean M Davidson, Derek M Yellon
Alleviating myocardial injury associated with ST elevation myocardial infarction is central to improving the global burden of coronary heart disease. The chemokine stromal cell-derived factor 1α (SDF-1α) has dual potential benefit in this regard. Firstly, SDF-1α is up-regulated in experimental and clinical studies of acute myocardial infarction (AMI) and regulates stem cell migration to sites of injury. SDF-1α delivery to the myocardium after AMI is associated with improved stem cell homing, angiogenesis, and left ventricular function in animal models, and improvements in heart failure and quality of life in humans...
September 2014: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/24051679/prognostic-impact-of-anaemia-on-patients-with-st-elevation-myocardial-infarction-treated-by-primary-pci
#7
Krishnaraj S Rathod, Daniel A Jones, Vrijraj S Rathod, Daniel Bromage, Oliver Guttmann, Sean M Gallagher, Saidi Mohiddin, Martin T Rothman, Charles Knight, Ajay K Jain, Akhil Kapur, Anthony Mathur, Adam D Timmis, Rajiv Amersey, Andrew Wragg
AIM: The aim of this study was to investigate the effects of baseline anaemia on the outcome in patients treated by primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction. METHODS: This study was a retrospective cohort study of 2418 patients with ST-elevation myocardial infarction treated by PPCI between January 2004 and August 2010 at a single centre. We investigated the outcome in patients with anaemia compared with that in patients with a normal haemoglobin (Hb) level...
January 2014: Coronary Artery Disease
https://www.readbyqxmd.com/read/23811175/out-of-hours-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-is-not-associated-with-excess-mortality-a-study-of-3347-patients-treated-in-an-integrated-cardiac-network
#8
Krishnaraj S Rathod, Daniel A Jones, Sean M Gallagher, Daniel I Bromage, Mark Whitbread, Andrew R Archbold, Ajay K Jain, Anthony Mathur, Andrew Wragg, Charles J Knight
OBJECTIVES: Timely delivery of primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment elevation myocardial infarction (STEMI). Optimum delivery of PPCI requires an integrated network of hospitals, following a multidisciplinary, consultant-led, protocol-driven approach. We investigated whether such a strategy was effective in providing equally effective in-hospital and long-term outcomes for STEMI patients treated by PPCI within normal working hours compared with those treated out-of-hours (OOHs)...
2013: BMJ Open
https://www.readbyqxmd.com/read/22701007/anomalous-right-coronary-artery-originating-from-the-left-main-stem
#9
Daniel Bromage, Toby Hall, Rob Lowe
No abstract text is available yet for this article.
April 13, 2011: BMJ Case Reports
https://www.readbyqxmd.com/read/22689276/therapeutic-hypothermia-after-cardiac-arrest-in-a-66-year-old-man
#10
Daniel Ian Bromage, Andrew Padkin
Hypoxic-ischaemic brain injury is an important cause of morbidity and mortality following both in- and out-of-hospital cardiac arrest. Despite significant advances in critical care the only intervention proven to increase survival rates after cardiac arrest is mild hypothermia. The authors present a case describing the use of therapeutic hypothermia after ventricular fibrillation cardiac arrest, including its indications and contra-indications, and the techniques that can be used to induce it.
2011: BMJ Case Reports
https://www.readbyqxmd.com/read/22580258/improving-informed-consent-in-percutaneous-coronary-revascularisation
#11
REVIEW
Daniel I Bromage, Joanna Lim, Ruud ter Meulen, Steve Ramcharitar
Informed consent is indispensable in contemporary medicine, especially in cases where the risks are high or there is true clinical equipoise, as in much invasive cardiology and cardiothoracic surgery practice. In this article we illustrate the principle of informed consent and describe how consent requirements have become more exacting in response to the rise of autonomy as the dominant principle in biomedical ethics. We outline some criticisms of informed consent, discuss why current requirements may never be achievable, and describe some of the vast literature aimed at "solving" the problem...
May 15, 2012: EuroIntervention
https://www.readbyqxmd.com/read/22458578/new-technologies-aimed-at-percutaneous-intervention-in-the-small-coronary-artery
#12
REVIEW
Daniel I Bromage, Joanna C E Lim, Steve Ramcharitar
Percutaneous coronary intervention (PCI) of small vessels can be complicated by technically difficult access to the target lesion, an increased risk of major adverse cardiac events and in-stent restenosis requiring repeat revascularization. Conventional management of such lesions is with drug-eluting stent implantation; however, these have only partly attenuated the problem. In response, several medical device companies are competing to produce new technologies aimed at PCI in small coronary arteries. Such innovations include thin-strutted stents, stent-on-a-wire systems, drug-coated balloons, endothelial progenitor cell-catching stents and biodegradable stent systems...
April 2012: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/19380812/phagocytosis-in-macrophages-lacking-cbl-reveals-an-unsuspected-role-for-fc-gamma-receptor-signaling-and-actin-assembly-in-target-binding
#13
Benjamin M Dale, Daniel Traum, Hediye Erdjument-Bromage, Paul Tempst, Steven Greenberg
Fc gamma receptor (Fc gammaR)-mediated phagocytosis is known to require tyrosine kinases (TKs). We identified c-Cbl and Cbl-b as proteins that undergo tyrosine phosphorylation during phagocytosis. Cbl-deficient macrophages displayed enhanced Fc gammaR-mediated signaling and phagocytosis. Surprisingly, binding of IgG-coated targets (EIgG) was also enhanced. c-Cbl-deficient macrophages expressed less Fc gammaRIIb, the inhibitory Fc gamma receptor; however, this did not account for enhanced target binding. We isolated the function of one Fc receptor isoform, Fc gammaRI, using IgG2a-coated targets (EIgG2a)...
May 1, 2009: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/15485911/the-yaf9-component-of-the-swr1-and-nua4-complexes-is-required-for-proper-gene-expression-histone-h4-acetylation-and-htz1-replacement-near-telomeres
#14
Haiying Zhang, Daniel O Richardson, Douglas N Roberts, Rhea Utley, Hediye Erdjument-Bromage, Paul Tempst, Jacques Côté, Bradley R Cairns
Yaf9, Taf14, and Sas5 comprise the YEATS domain family in Saccharomyces cerevisiae, which in humans includes proteins involved in acute leukemias. The YEATS domain family is essential, as a yaf9Delta taf14Delta sas5Delta triple mutant is nonviable. We verify that Yaf9 is a stable component of NuA4, an essential histone H4 acetyltransferase complex. Yaf9 is also associated with the SWR1 complex, which deposits the histone H2A variant Htz1. However, the functional contribution of Yaf9 to these complexes has not been determined...
November 2004: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/15126497/mutual-targeting-of-mediator-and-the-tfiih-kinase-kin28
#15
Benjamin W Guidi, Gudrun Bjornsdottir, Daniel C Hopkins, Lynne Lacomis, Hediye Erdjument-Bromage, Paul Tempst, Lawrence C Myers
In Saccharomyces cerevisiae, Kin28 is a member of the cyclin-dependent kinase family. Kin28 is a subunit of the basal transcription factor holo-TFIIH and its trimeric sub-complex TFIIK. Kin28 is the primary kinase that phosphorylates the RNA polymerase II (RNA pol II) C-terminal domain (CTD) within a transcription initiation complex. Mediator, a global transcriptional co-activator, dramatically enhances the phosphorylation of the CTD of RNA pol II by holo-TFIIH in vitro. Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that Mediator enhances phosphorylation of a glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase...
July 9, 2004: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/11714725/purification-and-characterization-of-the-human-elongator-complex
#16
Nicola A Hawkes, Gabriel Otero, G Sebastiaan Winkler, Nick Marshall, Michael E Dahmus, Daniel Krappmann, Claus Scheidereit, Claire L Thomas, Giampietro Schiavo, Hediye Erdjument-Bromage, Paul Tempst, Jesper Q Svejstrup
Human Elongator complex was purified to virtual homogeneity from HeLa cell extracts. The purified factor can exist in two forms: a six-subunit complex, holo-Elongator, which has histone acetyltransferase activity directed against histone H3 and H4, and a three-subunit core form, which does not have histone acetyltransferase activity despite containing the catalytic Elp3 subunit. Elongator is a component of early elongation complexes formed in HeLa nuclear extracts and can interact directly with RNA polymerase II in solution...
January 25, 2002: Journal of Biological Chemistry
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