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https://www.readbyqxmd.com/read/29454126/iatrogenic-spondylolisthesis-following-open-lumbar-laminectomy-case-series-and-review-of-the-literature
#1
Seba Ramhmdani, Yuanxuan Xia, Risheng Xu, Thomas Kosztowski, Daniel Sciubba, Timothy Witham, Ali Bydon
OBJECTIVE: The diagnosis and surgical management of post-laminectomy spondylolisthesis in patients without pre-operative instability is presented with a review of relevant literature. METHODS: We reviewed the medical records and radiographic studies of 105 patients who underwent first-time bilateral 1-4 level open laminectomies for degenerative lumbar disease at a single academic institution. Patients who initially presented with listhesis and had additional discectomy or fusion procedures were excluded...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453795/inflammatory-and-degenerative-phases-resulting-from-anterior-cruciate-rupture-in-a-non-invasive-murine-model-of-post-traumatic-osteoarthritis
#2
Sophie Jane Gilbert, Cleo Selina Bonnet, Paulina Stadnik, Victor Colin Duance, Deborah JaneMason, Emma Jane Blain
Joint injury is the predominant risk factor for post-traumatic osteoarthritis development (PTOA). Several non-invasive mouse models mimicking human PTOA investigate molecular mechanisms of disease development; none have characterised the inflammatory response to this acute traumatic injury. Our aim was to characterise the early inflammatory phase and later degenerative component in our in vivo non-invasive murine model of PTOA induced by anterior cruciate ligament (ACL) rupture. Right knees of 12-week-old C57Bl6 mice were placed in flexion at a 30° offset position and subjected to a single compressive load (12N, 1...
February 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29440589/intraobserver-and-interobserver-agreement-on-the-radiographical-diagnosis-of-canine-cranial-cruciate-ligament-rupture
#3
Evelien Bogaerts, Elke Van der Vekens, Geert Verhoeven, Hilde de Rooster, Bernadette Van Ryssen, Yves Samoy, Ingrid Putcuyps, Johan Van Tilburg, Nausikaa Devriendt, Frederik Weekers, Mileva Bertal, Blandine Houdellier, Stephanie Scheemaeker, Jeroen Versteken, Maryline Lamerand, Laurien Feenstra, Luc Peelman, Filip Van Nieuwerburgh, Jimmy H Saunders, Bart J G Broeckx
Even though radiography is one of the most frequently used imaging techniques for orthopaedic disorders, it has been demonstrated that the interpretation can vary between assessors. As such, the purpose of this study was to examine the intraobserver and interobserver agreement and the influence of level of expertise on the interpretation of radiographs of the stifle in dogs with and without cranial cruciate ligament rupture (CCLR). Sixteen observers, divided in four groups according to their level of experience, evaluated 30 radiographs (15 cases with CCLR and 15 control stifles) twice...
February 9, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29439066/effect-of-an-increased-dosage-of-statins-on-spinal-degenerative-joint-disease-a-retrospective-cohort-study
#4
Yuan-Yang Cheng, Chung-Lan Kao, Shih-Yi Lin, Shin-Tsu Chang, Tz-Shiang Wei, Shih-Ni Chang, Ching-Heng Lin
OBJECTIVES: It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases. DESIGN: A retrospective cohort study. SETTING: Patients registered in Taiwan National Health Insurance Research Database...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29434299/quantitative-morphometry-for-osteochondral-tissues-using-second-harmonic-generation-microscopy-and-image-texture-information
#5
Takashi Saitou, Hiroshi Kiyomatsu, Takeshi Imamura
Osteoarthritis (OA) is a chronic joint disorder involving degeneration of articular cartilage and subchondral bone in joints. We previously established a second harmonic generation (SHG) imaging technique for evaluating degenerative changes to articular cartilage in an OA mouse model. SHG imaging, an optical label-free technique, enabled observation of collagen fibrils, and characterized critical changes in the collagenous patterns of the joints. However, it still remains to be determined how morphological changes in the organization of tissue collagen fibrils should be quantified...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432995/long-noncoding-rna-maternally-expressed-gene-3-knockdown-alleviates-lipopolysaccharide-induced-inflammatory-injury-by-up-regulation-of-mir-203-in-atdc5-cells
#6
Zhaolin Wang, Xiaohua Chi, Liping Liu, Yaqun Wang, Xiaoyan Mei, Yan Yang, Tanghong Jia
BACKGROUND: Osteoarthritis (OA) is a common degenerative joint disease, which seriously impacts the health of elderly. However, there is no effective treatment for curing this disease until now. Numerous studies reported that long noncoding RNAs (lncRNAs) are closely related to the pathogenesis of OA. Therefore, the study aims to investigate the effect of maternally expressed gene 3 (MEG3) on lipopolysaccharide (LPS)-induced inflammatory injury of ATDC5 cells. METHODS: Different concentrations (0, 1, 5, and 10 μg/ml) of LPS were used to induce ATDC5 cells injury...
February 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29431217/the-role-of-mast-cells-in-autoinflammation
#7
REVIEW
Hanna Bonnekoh, Jörg Scheffel, Naotomo Kambe, Karoline Krause
The concept of autoinflammation was proposed to define a new class of immune disorders categorized by self-directed inflammation that is driven via activation of innate immune pathways. Within innate immunity, inflammasomes serve as intracellular signaling platforms to endogenous danger molecules and pathogens. Their key function is the cleavage of pro-interleukin-1β (pro-IL-1β) into its active form to promote inflammation and programmed cell death. A growing number of inflammasome sensors were described, among which NLR family pyrin domain containing 3 (NLRP3) is the best-studied sensor...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29430715/characterization-and-comparison-of-rat-monosodium-iodoacetate-and-medial-meniscal-tear-models-of-osteoarthritic-pain
#8
Jill-Desiree Brederson, Katharine L Chu, Jun Xu, Arthur L Nikkel, Stella Markosyan, Michael F Jarvis, Rebecca Edelmayer, Robert S Bitner, Steve McGaraughty
Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, however, the cellular mechanisms underlying OA are not fully understood. We characterized the medial meniscal tear (MMT) surgical model and the intra-articular injection of monosodium iodoacetate (MIA) chemical model of OA in rats. Both models produced histological changes in the knee joint and associated bones consistent with OA pathology...
February 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29429984/detection-of-mir-22-mir-140-and-bone-morphogenetic-proteins-bmp-2-expression-levels-in-synovial-fluid-of-osteoarthritis-patients-before-and-after-arthroscopic-debridement
#9
Renjun Yang, Dianying Zhang, Kai Yu, Luping Sun, Jie Yang, Chunmei Zhao, Xiang Li, Yuhong Chen
BACKGROUND Osteoarthritis (OA) is a degenerative joint disease often present on the surface and edge of the joint and beneath cartilage forming new bone. Arthroscopy had been used for the treatment of knee OA. This study aimed to measure the expression of miR-22, miR-140, and BMP-2 in patients with OA before and after arthroscopy operation. MATERIAL AND METHODS The synovial fluid of 80 patients and 60 healthy volunteers were aspirated using a syringe before OA operation and again six months post-operation in patients with OA...
February 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29425343/prevalence-and-causes-of-musculoskeletal-impairment-in-mahabubnagar-district-telangana-state-india-results-of-a-population-based-survey
#10
Tracey Smythe, Islay Mactaggart, Hannah Kuper, G V S Murthy, Christopher Lavy, Sarah Polack
Background: Musculoskeletal impairments (MSI) are the leading contributor to global years lived with disability. Comparable epidemiological data on MSI is lacking, and are needed to inform health and rehabilitative services. This study aimed to estimate the prevalence and causes of MSI in Telangana State, India. Method: A population-based survey used probability proportionate to size and compact-segment sampling to select 51 clusters of 80 individuals (all ages)...
February 7, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29415892/inhibition-of-wnt-%C3%AE-catenin-signaling-ameliorates-osteoarthritis-in-a-murine-model-of-experimental-osteoarthritis
#11
Caressa Lietman, Brian Wu, Sarah Lechner, Andrew Shinar, Madhur Sehgal, Evgeny Rossomacha, Poulami Datta, Anirudh Sharma, Rajiv Gandhi, Mohit Kapoor, Pampee P Young
Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important regulator of tissue repair and fibrosis. This study seeks to examine Wnt pathway effects on synovial fibroblasts and articular chondrocytes as well as the therapeutic effects of Wnt inhibition on OA disease severity. Mice underwent destabilization of the medial meniscus surgery and were treated by intra-articular injection with XAV-939, a small-molecule inhibitor of Wnt/β-catenin signaling...
February 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29410585/extension-of-knee-immobilization-delays-recovery-of-histological-damages-in-the-anterior-cruciate-ligament-insertion-and-articular-cartilage-in-rabbits
#12
Hirotaka Mutsuzaki, Hiromi Nakajima, Masataka Sakane
[Purpose] To investigate the influence of knee immobilization period on recovery of histological damages in the anterior cruciate ligament (ACL) insertion and articular cartilage in rabbits. This knowledge is important for determining the appropriate rehabilitation approach for patients with ligament injuries, fracture, disuse atrophy, and degenerative joint disease. [Materials and Methods] Forty-eight male Japanese white rabbits were divided equally into the remobilization and control groups. The remobilization group had the right knee surgically immobilized, and was divided equally into four subgroups according to the duration of immobilization (1, 2, 4 and 8 weeks)...
January 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29409219/-%C3%A2-diagnostic-and-therapeutic-injections-of-the-foot-and-ankle-an-overview
#13
REVIEW
Cesar de Cesar Netto, Lucas Furtado da Fonseca, Felipe Simeone Nascimento, Andres Eduardo O'Daley, Eric W Tan, Eric J Dein, Alexandre Leme Godoy-Santos, Lew Charles Schon
Foot and ankle injections are useful diagnostic and therapeutic tools, particularly when the pain etiology is uncertain. A variety of foot and ankle injuries and pathologies, including degenerative joint disease, plantar fasciitis and different tendinopathies are amenable to injections. Understanding the foot and ankle anatomical landmarks, a thorough physical exam and knowledge of the different injection techniques is key for a successful approach to different pathologies. The objective of this study is to review the use of foot and ankle injections in the orthopaedic literature, present the readers with the senior author's experience and provide a comprehensive clinical guideline to the most common foot and ankle diagnostic and therapeutic injections...
February 14, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29399463/adipose-derived-stem-cell-transplant-technique-for-degenerative-joint-disease
#14
Ryan P Coughlin, Alexander Oldweiler, Dayne T Mickelson, Claude T Moorman
The treatment of mild to moderate osteoarthritis can be a challenging problem for orthopaedic surgeons. As new research and treatment strategies have emerged, stem cell therapy has risen in popularity for the management of degenerative joint conditions. In this article, we describe a stepwise technical approach with tips and pearls to performing adipose-derived stem cell transplantation for degenerative joint disease of the knee.
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29398991/comparative-evaluation-of-surgical-procedures-with-clinical-equipoise-the-unique-perspective-of-our-hand-therapy-colleagues
#15
Joseph J Schreiber, Susan Clark, Jeffrey Yao
Background: There are several accepted surgical treatment options available for carpal tunnel syndrome, thumb carpometacarpal joint (CMC), osteoarthritis (OA), and wrist degenerative joint disease. Questions/Purposes: We sought to obtain the views and preferences from a cohort of certified hand therapists (CHT) and hypothesized that this source may identify differences in procedures that are otherwise widely believed to have clinical equipoise. Methods: Five hundred twelve CHTs were surveyed regarding their experience, volume, and referral base along with their subjective assessments and preferences regarding open versus endoscopic carpal tunnel release (CTR), various surgical procedures for CMC OA, and proximal row carpectomy (PRC) versus 4-corner fusion (4-CF)...
February 2018: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/29395553/arthroscopic-ankle-arthrodesis-a-2-15%C3%A2-year-follow-up-study
#16
Christopher Robert Jones, Eric Wong, Gregory R Applegate, Richard D Ferkel
PURPOSE: The purpose of our study was to determine the results of arthroscopic ankle arthrodesis (AAA) and how the procedure affects adjoining joints and functional scores. METHODS: Between 1993 and 2013, 116 patients (120 ankles) underwent AAA. Nineteen ankles were lost to follow-up due to death, insufficient radiographic studies, or inability to contact, resulting in 97 patients (101 ankles). Mean age at surgery was 61.1 years (range, 35.8-79.6 years); mean follow-up was 86 months (range, 24-247 months)...
January 25, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29395449/do-signs-of-an-effusion-of-the-temporomandibular-joint-on-magnetic-resonance-imaging-correlate-with-signs-and-symptoms-of-temporomandibular-joint-disease
#17
N Thomas, D E Harper, S Aronovich
Effusions are common among patients with disorders of the temporomandibular joint (TMJ), but publications are limited and results inconsistent about the correlation between them and important clinical variables, in particular severity of pain and degenerative disease. We organised a retrospective study of patients who presented for the evaluation and management of arthralgia of the TMJ and myofascial pain at the University of Michigan between 2011 and 2014. Inclusion criteria were: patients who had pain that was primarily arthrogenous, and coexisting myogenous pain, who had had initial non-surgical treatment, and arthroscopy of the TMJ with or without intramuscular injection of onabotulinumtoxinA (Botox,® Allegan, Weston, Fl, USA)...
February 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29393342/cthrc1-mediates-il%C3%A2-1%C3%AE-%C3%A2-induced-apoptosis-in-chondrocytes-via-jnk1-2-signaling
#18
Qi Zhang, Zong-Sheng Yin, Fu-Wen Zhang, Kun Cao, He-Yan Sun
Osteoarthritis (OA), also known as degenerative joint disease or degenerative arthritis, is characterized by chondrocyte apoptosis. The aim of the present study was to investigate the effects of collagen triple helix repeat containing 1 (CTHRC1) and the c‑Jun N‑terminal kinase (JNK) 1/2 inhibitor SP600125 on rat chondrocytes cultured in vitro with interleukin (IL)‑1β. Chondrocytes were treated with different doses of IL‑1β and cell viability and CTHRC1 expression were assessed using Cell Counting Kit‑8 and western blot assays, respectively...
January 18, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29382613/changes-of-facet-joints-after-dynamic-stabilization-continuous-degeneration-or-slow-fusion
#19
Mei-Yin Yeh, Chao-Hung Kuo, Jau-Ching Wu, Wen-Cheng Huang, Tsung-Hsi Tu, Li-Yu Fay, Ching-Lan Wu, Henrich Cheng
BACKGROUND: The non-fusion pedicle-screw system Dynesys stabilization(DS) for lumbar degenerative disease aims to better preservation of range of motion(ROM) than fixation and fusion systems. However, decreased ROM and unexpected facet fusion at the index level were observed after DS applied with unknown etiology. The aim of this study is using radiological parameters to explain the phenomenon of facet arthrodesis. METHODS: The patients who underwent surgery for L4-5 spinal stenosis were sorted retrospectively into two groups: the DS, and the microdisectomy(MicD) groups...
January 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29379852/dataset-on-gait-patterns-in-degenerative-neurological-diseases
#20
Mariano Serrao, Giorgia Chini, Matteo Bergantino, Diego Sarnari, Carlo Casali, Carmela Conte, Alberto Ranavolo, Christian Marcotulli, Martina Rinaldi, Gianluca Coppola, Fabiano Bini, Francesco Pierelli, Franco Marinozzi
We collected the gait parameters and lower limb joint kinematics of patients with three different types of primary degenerative neurological diseases: (i) cerebellar ataxia (19 patients), (ii) hereditary spastic paraparesis (26 patients), and (iii) Parkinson's disease (32 patients). Sixty-five gender-age matched healthy subjects were enrolled as control group. An optoelectronic motion analysis system was used to measure time-distance parameters and lower limb joint kinematics during gait in both patients and healthy controls...
February 2018: Data in Brief
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