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https://www.readbyqxmd.com/read/29226200/long-term-results-of-osteoarticular-allograft-reconstruction-in-children-with-distal-femoral-bone-tumors
#1
Khodamorad Jamshidi, Mehrdad Bahrabadi, Alireza Mirzaei
Background: There is no consensus regarding the best method of reconstruction in pediatric population following the wide resection of malignant bone tumors. More exploration of the complications of osteoarticular reconstruction leads to less existing controversy of this type of reconstruction, which is the main point of this article. Methods: Long-term outcomes and complications of osteoarticular allograft reconstruction of primary distal femoral bone sarcomas in 22 children with mean age of 10...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29225364/a-young-patient-with-temporomandibular-joint-osteoarthritis-case-report
#2
Ema Vrbanović, Iva Z Alajbeg
This paper describes a case of a young patient who sought help because of pain in the right temporomandibular joint (TMJ). She also reported increasing of pain during chewing. Clinical examination revealed limited mouth opening with uncorrected deviation to the ipsilateral side. Palpation of the lateral pole of the right condyle discovered crepitus, and maximum assisted opening elicited a report of "familiar pain". The diagnosis of osteoarthritis of the TMJ (RDC / TMD criteria, Axis I, Group III) was confirmed by CBCT of TMJ...
September 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/29214554/geniposide-suppresses-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-chondrocytes-via-the-pi3k-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#3
Tianlong Pan, Xuchao Shi, Huan Chen, Rong Chen, Dengying Wu, Zeng Lin, Jingdong Zhang, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is principally characterized by progressive joint dysfunction and cartilage degradation. Inflammation and apoptosis play critical roles in the progression of OA. Geniposide (GPO), one of the principal components of the fruit of Gardenia jasminoides Ellis, has been reported to have anti-inflammatory and other pharmacological effects. In this study, we performed in vitro experiments on rat chondrocytes to examine the therapeutic effects of GPO on OA and investigated its effects in vivo in a rat model of OA induced by medial meniscal tear (MMT)...
December 6, 2017: Inflammation
https://www.readbyqxmd.com/read/29208195/-treatment-principles-in-bone-reconstruction-and-limb-lengthening-of-the-lower-extremity
#4
Ulrik Kæhler Olesen, Tobias Nygaard, Søren V Kold, Adam Hede
Limb length discrepancies, axis deviations and bone loss on a congenital, traumatic or infectious basis are treated with restoration of axis and bone elongation. The intention is to improve gait and function, to relieve pain caused by imbalance in the musculoskeletal system and to prevent degenerative joint disease. Modern motorized intramedullary nails spare the patients for external fixators, and thus complications are being reduced. X-ray, CT-based planning and a thorough clinical examination is essential for a good result...
November 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29206989/work-related-biomechanical-exposure-and-job-strain-as-separate-and-joint-predictors-of-musculoskeletal-diseases-a-28-year-prospective-follow-up-study
#5
K C Prakash, Subas Neupane, Päivi Leino-Arjas, Mikaela B von Bonsdorff, Taina Rantanen, Monika E von Bonsdorff, Jorma Seitsamo, Juhani Ilmarinen, Clas-Håkan Nygård
We investigated how work-related biomechanical exposure and job strain in midlife separately and jointly predicted back and degenerative musculoskeletal diseases (MSDs). A total of 6,257 employees participated in the Finnish Longitudinal Study on Aging Municipal Employees (FLAME) in 1981 and were followed up for 28 years. Risk ratios and the relative excessive risk due to interaction and 95% confidence intervals were modeled for separate and joint prediction estimates, respectively. After adjustment for confounders, job strain predicted degenerative MSDs among women after 4 and 11 years of follow-up...
December 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29202567/the-use-of-hyaluronic-acid-in-the-treatment-of-ankle-osteoarthritis-a-review-of-the-evidence
#6
R Papalia, E Albo, F Russo, A Tecame, G Torre, S Sterzi, F Bressi, V Denaro
Ankle osteoarthritis (OA) is a progressive degenerative joint disease that causes ankle pain and functional limitation especially during walking. It tends to involve younger people with high functional request and has often a post-traumatic origin. Symptoms control through conservative treatment is essential to procrastinate as long as possible the need for surgery. Although few data are present in literature about the use of local viscosupplementation in ankle OA, their potential use for ankle OA has been suggested...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29201384/rottweilers-under-primary-veterinary-care-in-the-uk-demography-mortality-and-disorders
#7
Dan G O'Neill, Wee Yin Seah, David B Church, Dave C Brodbelt
Background: Rottweilers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commonly recorded diseases in Rottweilers under UK veterinary care. Clinical health records within the VetCompass Programme were explored for disorders recorded during 2013. Results: Rottweilers comprised 5321 (1.17%) of 455,557 dogs attending 304 clinics. Annual proportional birth rates dropped from 1...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/29199605/modeling-mesenchymal-stem-cells-in-tmj-rheumatoid-arthritis-and-osteoarthritis-therapy
#8
Nedime Serakinci, Gokce Savtekin
Stem cells have self-renewal capacity and an ability to differentiate into particular cell types generating mature cells. Mesenchymal stem cells (MSCs) have a significant role in tissue homeostasis, which leads into tissue regeneration. MSCs are rare pluripotent cells supporting hematopoietic and mesenchymal cell lineages. MSCs are also believed to have therapeutic power over temporomandibular joint (TMJ) disorders (TMDs). The most common type of TMD is articular disc displacement, which induces progressive degenerative changes...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29197416/joint-awareness-in-posttraumatic-osteoarthritis-of-the-knee-validation-of-the-forgotten-joint-score-in-long-term-condition-after-tibial-plateau-fracture
#9
Florian Baumann, Johannes Weber, Daniel Mahr, Martin Bäumlein, Maximilian Kerschbaum, Karolina Müller, Paavo Rillmann, Michael Nerlich, Markus Loibl
BACKGROUND: Evaluating patient-reported outcomes (PRO) in early osteoarthritis (OA) of the knee is difficult. Established measurement tools are focused on one of the two major patient groups in knee surgery: young, highly active patients, or older patients with advanced degenerative OA of the knee. Joint awareness in everyday life is a crucial criterion in measuring PRO. The purpose of this study was to validate a German version of the "Forgotten Joint Score" (FJS) in patients after surgical treatment of tibial plateau fractures...
December 2, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29186157/finite-element-simulation-and-clinical-follow-up-of-lumbar-spine-biomechanics-with-dynamic-fixations
#10
Yolanda Más, Luis Gracia, Elena Ibarz, Sergio Gabarre, Diego Peña, Antonio Herrera
Arthrodesis is a recommended treatment in advanced stages of degenerative disc disease. Despite dynamic fixations were designed to prevent abnormal motions with better physiological load transmission, improving lumbar pain and reducing stress on adjacent segments, contradictory results have been obtained. This study was designed to compare differences in the biomechanical behaviour between the healthy lumbar spine and the spine with DYNESYS and DIAM fixation, respectively, at L4-L5 level. Behaviour under flexion, extension, lateral bending and axial rotation are compared using healthy lumbar spine as reference...
2017: PloS One
https://www.readbyqxmd.com/read/29185286/lessons-learned-from-imaging-on-enthesitis-in-psoriatic-arthritis
#11
REVIEW
Abdulla Watad, Iris Eshed, Dennis McGonagle
Enthesitis is a term that refers to inflammation at tendon, ligament, or joint capsule insertions. The entheses are increasinlgly considered to be the primary site of joint inflammation in the spondyloarthropathies including psoriatic arthritis (PsA). Great advances have occurred in the understanding of enthesopathy, which has resulted in a better understanding of the etiopathogenesis of PsA. Enthesitis is difficult to assess on both clinical examination and on imaging because of the overlap in features between mechanical, degenerative, and inflammatory pathologies...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29182124/hip-preservation-surgery-for-adolescents-and-young-adults-with-post-perthes-sequelae
#12
M A Eid
BACKGROUND: Impingement ensures a narrow arc of pathologic loading in adolescent hips with sequelae of Perthes Disease. Proper surgical interference when the hip is still in the pre-arthritic stage restores function and protects the young hip from early degenerative changes. METHODS: Osteochondroplasty at the femoral head-neck junction and relative lengthening of the femoral neck by distal transfer of the greater trochanter was performed for 12 adolescents with combined intra-articular/extra-articular impingement due to sequelae of Perthes disease in terms of coxa magna, coxa plana, coxa brevis, with an overriding greater trochanter...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29168867/the-protective-effect-of-phloretin-in-osteoarthritis-an-in-vitro-and-in-vivo-study
#13
Wenhao Zheng, Chunhui Chen, Chuanxu Zhang, Leyi Cai, Hua Chen
Osteoarthritis (OA) is a degenerative joint disease characterized by the degradation and inflammation of cartilage. Phloretin, a type of dihydrochalcone mainly found in apples and apple-derived products, has been reported to possess various potent biological effects such as antioxidant, anticancer, anti-inflammatory, and immunomodulatory. However, the anti-inflammatory effects of phloretin on OA have not been reported. This study was aimed at assessing the effects of phloretin on human OA chondrocytes. Human OA chondrocytes were pretreated with phloretin (10, 30, and 100 μM) for 2 h and subsequently stimulated with IL-1β for 24 h...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29166933/correlation-between-facet-tropism-and-lumbar-degenerative-disease-a-retrospective-analysis
#14
Tian Gao, Qi Lai, Song Zhou, Xuqiang Liu, Yuan Liu, Ping Zhan, Xiaolong Yu, Jun Xiao, Min Dai, Bin Zhang
BACKGROUND: The aim of this study was to investigate the correlation between facet tropism and spinal degenerative diseases, such as degenerative lumbar spondylolisthesis, degenerative lumbar scoliosis, and lumbar disc herniation. METHODS: This study retrospectively analysed clinical data from the Department of Orthopaedics at The First Affiliated Hospital of Nanchang University. Ninety-two patients were diagnosed with lumbar spondylolisthesis, 64 patients with degenerative scoliosis, and 86 patients with lumbar disc herniation between 1 October 2014 and 1 October 2016...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29162138/predictability-of-the-effects-of-facet-joint-infiltration-in-the-degenerate-lumbar-spine-when-assessing-mri-scans
#15
Ulf Krister Hofmann, Ramona Luise Keller, Christian Walter, Falk Mittag
BACKGROUND: Imaging results are frequently considered as hallmarks of disease by spine surgeons to plan their future treatment strategy. Numerous classification systems have been proposed to quantify or grade lumbar magnetic resonance imaging (MRI) scans and thus objectify imaging findings. The clinical impact of the measured parameters remains, however, unclear. To evaluate the pathological significance of imaging findings in patients with multisegmental degenerative findings, clinicians can perform image-guided local infiltrations to target defined areas such as the facet joints...
November 21, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29156945/modulation-of-gene-expression-in-infrapatellar-fat-pad-derived-mesenchymal-stem-cells-in-osteoarthritis
#16
Beatriz Bravo, Jose Manuel Argüello, Arancha R Gortazar, Francisco Forriol, Javier Vaquero
Aim In the osteoarthritis (OA) disease, all structures of the joint are involved. The infrapatellar Hoffa fat pad is rich in macrophages and granulocytes, which also represents a source of adipose mesenchymal progenitor cells (ASC) cells. In our study, we analyze how OA affects the ability of ASC-derived from Hoffa's fat pad to differentiate into chondrocytes. Material and methodology We took knee Hoffa's pad samples and adipose tissue from the proximal thigh from 6 patients diagnosed with severe OA and from another 6 patients with an anterior cruciate ligament (ACL) rupture without OA...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29153234/evaluation-of-pain-syndromes-headache-and-temporomandibular-joint-disorders-in-children
#17
REVIEW
Bruce B Horswell, Jason Sheikh
After a thorough review of the history and presentation of a child's facial pain, a targeted head and neck examination is critical to the appropriate diagnosis of facial pain and temporomandibular joint disorders. It is critical to distinguish between the structural (trauma, degenerative disease, and tumor) and nonstructural (neurogenic, myogenic, and psychological) causes of pain, which will allow for incorporation of appropriate strategies of medical, psychological, dental, and surgical therapies.
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29152560/effects-of-inflammation-on-multiscale-biomechanical-properties-of-cartilaginous-cells-and-tissues
#18
REVIEW
Q T Nguyen, T D Jacobsen, N O Chahine
Cells within cartilaginous tissues are mechanosensitive and thus require mechanical loading for regulation of tissue homeostasis and metabolism. Mechanical loading plays critical roles in cell differentiation, proliferation, biosynthesis, and homeostasis. Inflammation is an important event occurring during multiple processes, such as aging, injury, and disease. Inflammation has significant effects on biological processes as well as mechanical function of cells and tissues. These effects are highly dependent on cell/tissue type, timing, and magnitude...
November 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29150953/new-algorithm-for-simulation-of-proteoglycan-loss-and-collagen-degeneration-in-the-knee-joint-data-from-the-osteoarthritis-initiative
#19
Mika E Mononen, Petri Tanska, Hanna Isaksson, Rami K Korhonen
Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan content, fluid flow and collagen fibril network) occurring in osteoarthritis. While excessive levels of tissue stresses controlled degeneration of the collagen fibril network, excessive levels of tissue strains controlled the decrease in proteoglycan content and the increase in permeability...
November 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29145437/assessment-of-the-suitability-of-biodegradable-rods-for-use-in-posterior-lumbar-fusion-an-in-vitro-biomechanical-evaluation-and-finite-element-analysis
#20
Fon-Yih Tsuang, Yueh-Ying Hsieh, Yi-Jie Kuo, Chia-Hsien Chen, Feng-Huei Lin, Chen-Sheng Chen, Chang-Jung Chiang
Interbody fusion with posterior instrumentation is a common method for treating lumbar degenerative disc diseases. However, the high rigidity of the fusion construct may produce abnormal stresses at the adjacent segment and lead to adjacent segment degeneration (ASD). As such, biodegradable implants are becoming more popular for use in orthopaedic surgery. These implants offer sufficient stability for fusion but at a reduced stiffness. Tailored to degrade over a specific timeframe, biodegradable implants could potentially mitigate the drawbacks of conventional stiff constructs and reduce the loading on adjacent segments...
2017: PloS One
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