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Degenerative joint disease

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https://www.readbyqxmd.com/read/29663159/evaluation-of-the-effect-of-polyphenol-of-escin-compared-with-ibuprofen-and-dexamethasone-in-synoviocyte-model-for-osteoarthritis-an-in-vitro-study
#1
Hossein Maghsoudi, Jamal Hallajzadeh, Mozhghan Rezaeipour
Osteoarthritis (OA) is a chronic degenerative joint disease with inflammatory component. It is associated with progressive histological alterations and disabling symptoms. Today, drugs such as glucocorticoids (GCs) and nonsteroidal anti-inflammatory drugs (NSIADs) are commonly employed for treatment of osteoarthritis, but have serious and life-threatening side effects. The aim of the current study is to evaluate the effects of escin on cyclooxygenase-2 (COX-2, isoform), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-18 (IL-18), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) (1), as well as prostaglandin E2 (PGE2) on inflammatory cells, similar osteoarthritis in synoviocytes, and monocytes/macrophages, and to compare it with dexamethasone (DEX) and ibuprofen (IBP)...
April 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29659379/bony-reconstruction-of-the-anterior-glenoid-rim
#2
Laurent B Willemot, Bassem T Elhassan, Olivier Verborgt
Recurrent anterior shoulder instability is associated with glenohumeral bone loss. Glenoid deficiency compromises the concavity-compression mechanism. Medial Hill-Sachs lesions can result in an off-track humeral position. Anterior glenoid reconstruction or augmentation prevents recurrence by addressing the pathomechanics. In Bristow and Latarjet procedures, the coracoid process is harvested for conjoint tendon transfer, capsular reinforcement, and glenoid rim restoration. Complications and the nonanatomic nature of the procedure have spurred research on graft sources...
April 13, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29629804/quantitative-assessment-of-degenerative-cartilage-and-subchondral-bony-lesions-in-a-preserved-cadaveric-knee-propagation-based-phase-contrast-ct-versus-conventional-mri-and-ct
#3
Tobias Geith, Emmanuel Brun, Alberto Mittone, Sergei Gasilov, Loriane Weber, Silvia Adam-Neumair, Alberto Bravin, Maximilian Reiser, Paola Coan, Annie Horng
OBJECTIVE: The aim of this study was to quantitatively assess hyaline cartilage and subchondral bone conditions in a fully preserved cadaveric human knee joint using high-resolution x-ray propagation-based phase-contrast imaging (PBI) CT and to compare the performance of the new technique with conventional CT and MRI. MATERIALS AND METHODS: A cadaveric human knee was examined using an x-ray beam of 60 keV, a detector with a 90-mm2 FOV, and a pixel size of 46 × 46 μm2 ...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29628809/cytokine-involvement-in-biological-inflammation-related-to-degenerative-disorders-of-the-intervertebral-disk-a-narrative-review
#4
REVIEW
Christopher M De Geer
Objective: The purpose of this narrative literature review is to discuss the literature regarding the potential role that cytokines play in degenerative disk disease. Methods: The inclusion criteria were studies that used inflammatory mediators in advancing disk disease processes. Research studies were limited to the last 3 decades that had free full-text available online in English. Exclusion criteria were review articles and articles pertaining to temporomandibular joints and other joints of the body other than the intervertebral disk...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29621430/17%C3%AE-estradiol-induces-mmp-9-and-mmp-13-in-tmj-fibrochondrocytes-via-estrogen-receptor-%C3%AE
#5
N Ahmad, S Chen, W Wang, S Kapila
Temporomandibular joint (TMJ) disorders, including degenerative TMJ disease, occur primarily in women of reproductive age. Previous studies showed elevated estrogen levels in subjects with TMJ disorders relative to controls and the presence of estrogen receptors α and β (ERα and ERβ) in TMJ fibrocartilage. Additionally, estrogen-induced overexpression of specific matrix metalloproteinases (MMPs), including MMP-9 and MMP-13, in TMJ fibrocartilage is accompanied by loss of extracellular matrices. However, the contribution of ERα and ERβ in estrogen-mediated induction of MMP-9 and MMP-13 and the signaling cascade leading to the upregulation of these MMPs have not been elucidated...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29611396/an-emerging-role-for-circular-rnas-in-osteoarthritis
#6
REVIEW
Chen Xi Yu, Shui Sun
Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form a covalently closed continuous loop without 5' or 3' polarities. With the development of high throughput sequencing technology, a large number of circRNAs have been discovered in many species. More importantly, growing evidence suggests that circRNAs are abundant, evolutionally conserved, and relatively stable in cells and tissues. Strikingly, recent studies have discovered that circRNAs can serve as microRNA sponges, interact with RNA-binding protein, and regulate gene transcription, as well as protein translation...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611158/decreased-time-to-return-to-work-using-robotic-assisted-unicompartmental-knee-arthroplasty-compared-to-conventional-techniques
#7
Alexander H Jinnah, Marco A Augart, Daniel L Lara, Riyaz H Jinnah, Gary G Poehling, Chukwuweike U Gwam, Johannes F Plate
INTRODUCTION: Unicompartmental knee arthroplasty (UKA) is a commonly used procedure for patients suffering from debilitating unicompartmental knee arthritis. For UKA recipients, robotic-assisted surgery has served as an aid in improving surgical accuracy and precision. While studies exist detailing outcomes of robotic UKA, to our knowledge, there are no studies assessing time to return to work using robotic-assisted UKA. Thus, the purpose of this study was to prospectively assess the time to return to work and to achieve the level of work activity following robotic-assisted UKA to create recommendations for patients preoperatively...
March 29, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29603329/calcium-calmodulin-dependent-protein-kinaseii-in-occlusion-induced-degenerative-cartilage-of-rat-mandibular-condyle
#8
Qian Liu, Hong-Xu Yang, Xiang-Hong Wan, Mian Zhang, Jing Zhang, Lei Lu, Mianjiao Xie, Hao-Tian Ren, Shi-Bin Yu, Xiao-Dong Liu, Meiqing Wang
Activated calcium/calmodulin dependent protein kinaseII (CaMKII) is important to promote chondrocytes from proliferative to pre-hypertrophic state, which probably plays a role in osteoarthritis (OA), a wide-spread degeneration disease with enhanced aberrant chondrocyte differentiation. Our aim is to detect the role of CaMKII, and its relationship with Indian hedgehog (Ihh)-Parathyroid-related peptide (PTHrP) feedback loop in the temporomandibular joints (TMJs) OA. KN93, the competitive inhibitor of CaMKII, was added to the culture medium in vitro, and was locally injected to rats TMJs (n=54, female) every other day for 4 weeks from the beginning of the 5th and 9th week after installing of unilateral anterior crossbite (UAC), termed as 4wk+4wk and 8wk+4wk, accordingly...
March 30, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29600558/when-elephants-fall-asleep-a-literature-review-on-elephant-rest-with-case-studies-on-elephant-falling-bouts-and-practical-solutions-for-zoo-elephants
#9
Christian Schiffmann, Stefan Hoby, Christian Wenker, Therese Hård, Robert Scholz, Marcus Clauss, Jean-Michel Hatt
Little attention has been paid to the resting and sleeping behavior of zoo elephants so far. An important concern is when elephants avoid lying down, due to degenerative joint and foot disease, social structure, or stressful environmental changes. Inability or unwillingness to lie down for resting is an important welfare issue, as it may impair sleep. We emphasize the importance of satisfying rest in elephants by reviewing the literature on resting behavior in elephants (Loxodonta africana and Elephas maximus) as well as the documentation of four cases from European zoos and our own direct observations in a zoo group of four female African elephants during 12 entire days...
March 30, 2018: Zoo Biology
https://www.readbyqxmd.com/read/29599843/platelet-rich-plasma-shows-beneficial-effects-for-patients-with-knee-osteoarthritis-by-suppressing-inflammatory-factors
#10
Guilin Huang, Sha Hua, Tuanmin Yang, Jianbing Ma, Wenxing Yu, Xiujin Chen
Knee osteoarthritis is a degenerative disease that may develop due ageing, obesity, strain, congenital abnormal joints, joint deformity or trauma. It is caused by many factors, such as degradation of articular cartilage injury, joint edge and subchondral bone hyperplasia of reactivity. Platelet-rich plasma (PRP) is an autologous blood sample that contains highly concentrated platelets and multiple cell growth factors. PRP promotes synovial cell proliferation and differentiation and may recover cartilage morphology...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29595277/-the-role-of-magnetic-resonance-imaging-in-diagnostics-of-axial-spondyloarthritis
#11
Martin Žlnay
Axial spondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder that primary affects axial skeleton. It comprises wide spectrum of patients with immune mediated spine inflammation, from early, so called non-radiographic axial spondyloarthritis to clinically evident ankylosing spondylitis. Conventional radiography is still the cornerstone of diagnosis, evaluation and classification of SpA. However, it has limitations in early disease, because it can only depict the consequences of inflammation for its inability to visualize soft tissue abnormalities within bone marrow...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29594113/interplay-of-inflammatory-mediators-with-epigenetics-and-cartilage-modifications-in-osteoarthritis
#12
REVIEW
Swarna Raman, Una FitzGerald, J Mary Murphy
Osteoarthritis (OA), a degenerative disease of diarthrodial joints, is influenced by mechanical and inflammatory factors with aging, obesity, chronic injuries, and secondary diseases thought to be major factors driving the process of articular cartilage degeneration. Chondrocytes, the cellular component of cartilage, reside in an avascular environment and normally have limited potential to replicate. However, extrinsic factors such as injury to the joint or intrinsic alterations to the chondrocytes themselves can lead to an altered phenotype and development of OA...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29588241/facet-joint-fixation-and-alif-dlif-or-tlif-for-treatment-of-degenerative-lumbar-disc-diseases-retrospective-cohort-study-of-a-new-minimally-invasive-technique
#13
Evgenii Belykh, Andrey A Kalinin, Nikolay L Martirosyan, Talgat Kerimbayev, Nicholas Theodore, Mark C Preul, Vadim A Byvaltsev
BACKGROUND: Anterior, direct lateral and transforaminal lumbar interbody fusions (ALIF, DLIF, and TLIF) are usually combined with posterior fixation to treat degenerative spinal diseases. Outcomes of ALIF, TLIF, or DLIF combined with a new wedge-shaped, interfacet cage-plate have not been reported. We assessed early clinical outcomes of patients treated with interbody fusion and facet fixation using a titanium wedge-shaped cage-plate. METHODS: This retrospective observational cohort study included patients (n=80) who underwent 1-level interbody fusion and facet joint fixation via ALIF (n=24) or DLIF (n=26) with bilateral facet fixation or TLIF with ipsilateral pedicle screws and contralateral facet fixation (n=30)...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29584640/greenshell%C3%A2-mussels-a-review-of-veterinary-trials-and-future-research-directions
#14
REVIEW
Charles T Eason, Serean L Adams, Jonathan Puddick, Donato Romanazzi, Matthew R Miller, Nick King, Sarah Johns, Elizabeth Forbes-Blom, Paul A Hessian, Lisa K Stamp, Michael A Packer
The therapeutic benefits of Greenshell™ mussel (GSM; Perna canaliculus ) preparations have been studied using in vitro test systems, animal models, and human clinical trials focusing mainly on anti-inflammatory and anti-arthritic effects. Activity is thought to be linked to key active ingredients that include omega-3 polyunsaturated fatty acids, a variety of carotenoids and other bioactive compounds. In this paper, we review the studies that have been undertaken in dogs, cats, and horses, and outline new research directions in shellfish breeding and high-value nutrition research programmes targeted at enhancing the efficacy of mussel and algal extracts...
March 27, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29575878/solec-spa-worldwide-unique-properties-of-polish-health-resort-in-the-service-of-rural-medicine
#15
Marek L Grabowski, Bożena Kosińska, Józef P Knap
Solec Spa is health resort in south-eastern Poland. Its unique balneorehabilitation significance worldwide is determined by chloride-iodine-sodium water with a high content of hydrogen sulphide. This water, classified as highly mineralized sodium-chloride (seltzer) sulphide, bromide, iodide, boron water, contains naturally approximately 0.9 g/l divalent sulphur compounds, which is the highest concentration noted among the mineral waters of the world. The effectiveness of the Solec waters is proven in: inflammatory and autoimmunological locomotor system diseases, degenerative joint disorders (osteoarthritis), post-traumatic and post-operative orthopedic diseases, skin diseases and allergic disorders...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29572481/tibial-osteotomy-as-a-mechanical-model-of-primary-osteoarthritis-in-rats
#16
David Britzman, Ibidumo Igah, Theofano Eftaxiopoulou, Warren Macdonald, Anthony M J Bull
This study has presented the first purely biomechanical surgical model of osteoarthritis (OA) in rats, which could be more representative of the human primary disease than intra-articular techniques published previously. A surgical tibial osteotomy (TO) was used to induce degenerative cartilage changes in the medial knee of Sprague-Dawley rats. The presence of osteoarthritic changes in the medial knee compartment of the operated animals was evaluated histologically and through analysis of serum carboxy-terminal telepeptides of type II collagen (CTX-II)...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29561298/pre-operative-chronic-opioid-therapy-a-risk-factor-for-complications-readmission-continued-opioid-use-and-increased-costs-after-one-and-two-level-posterior-lumbar-fusion
#17
Nikhil Jain, Frank M Phillips, Tristan Weaver, Safdar N Khan
STUDY DESIGN: Retrospective, economic analysis. OBJECTIVE: To study patient profile associated with preoperative chronic opioid therapy (COT), and study COT as a risk factor for 90-day complications, emergency department (ED) visits, and readmission after primary one- to two-level posterior lumbar fusion (PLF) for degenerative spine disease. We also evaluated associated costs, risk factors, and adverse events related to long-term postoperative opioid use. SUMMARY OF BACKGROUND DATA: Chronic opioid use is associated with poor outcomes and dependence after spine surgery...
March 20, 2018: Spine
https://www.readbyqxmd.com/read/29554150/effect-of-leukocyte-reduced-platelet-rich-plasma-on-osteoarthritis-caused-by-cranial-cruciate-ligament-rupture-a-canine-gait-analysis-model
#18
José M Vilar, Maria E Manera, Angelo Santana, Giuseppe Spinella, Oliver Rodriguez, Mónica Rubio, José M Carrillo, Joaquín Sopena, Miguel Batista
The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals...
2018: PloS One
https://www.readbyqxmd.com/read/29552504/anterior-cruciate-ligament-reconstruction-in-a-patient-who-has-received-systemic-steroids-for-autoimmune-disease
#19
Tetsuro Ushio, Ken Okazaki, Hideki Mizu-Uchi, Satoshi Hamai, Yukio Akasaki, Yasuharu Nakashima
Background: An anterior cruciate ligament (ACL) reconstruction has become more common and the surgical morbidity has decreased, it has been performed not only in younger people to play sports but also middle-aged people, with satisfactory results. Therefore, some patients might have comorbidities for which they take medicines. Especially the medicines, such as systemic steroids, might influence the reconstructed ligament strength and durability. Case report: A 49-year-old woman who was taking oral steroids for autoimmune hepatitis suffered a spontaneous ACL injury...
January 2018: Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
https://www.readbyqxmd.com/read/29538299/comparative-analysis-of-bone-structural-parameters-reveals-subchondral-cortical-plate-resorption-and-increased-trabecular-bone-remodeling-in-human-facet-joint-osteoarthritis
#20
Cordula Netzer, Pascal Distel, Uwe Wolfram, Hans Deyhle, Gregory F Jost, Stefan Schären, Jeroen Geurts
Facet joint osteoarthritis is a prominent feature of degenerative spine disorders, highly prevalent in ageing populations, and considered a major cause for chronic lower back pain. Since there is no targeted pharmacological therapy, clinical management of disease includes analgesic or surgical treatment. The specific cellular, molecular, and structural changes underpinning facet joint osteoarthritis remain largely elusive. The aim of this study was to determine osteoarthritis-related structural alterations in cortical and trabecular subchondral bone compartments...
March 14, 2018: International Journal of Molecular Sciences
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