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https://www.readbyqxmd.com/read/28428674/comparison-of-clinical-and-radiological-parameters-at-knee-osteoarthritis
#1
Adnana Talic-Tanovic, Zoran Hadziahmetovic, Ivanka Madjar-Simic, Adnan Papovic
INTRODUCTION: Osteoarthritis (OA) or arthrosis represents an inflammatory disease of joints that develops as a result of interaction of mechanical and biological parameters. With disease development, degenerative changes on joint cartilage can be noticeable that affect and cause pathological changes on other parts of a joint resulting in pain and dysfunction of a joint. A. E. Garrod in 1907 described osteoarthritis as a special clinical entity and separated it from a rheumatoid arthritis...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28427874/factors-that-increase-the-risk-of-infection-after-elbow-arthroscopy-analysis-of-patient-demographics-medical-comorbidities-and-steroid-injections-in-2-704-medicare-patients
#2
Christopher L Camp, Jourdan M Cancienne, Ryan M Degen, Joshua S Dines, David W Altchek, Brian C Werner
PURPOSE: To use a national database to determine (1) the incidence of joint infection after elbow arthroscopy, (2) identify independent patient-related risk factors for infection, and (3) determine the influence of concomitant intra-articular corticosteroid injection on infection risk. METHODS: The 100% Medicare Standard Analytic Files were queried to identify patients who underwent elbow arthroscopy from 2005 to 2012. Postoperative elbow infections occurring within 6 months of surgery were identified using both International Classification of Diseases, 9th Revision codes for postoperative infection and Current Procedural Terminology codes for the surgical treatment of a postoperative infection...
April 17, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28427725/association-of-mild-leg-length-discrepancy-and-degenerative-changes-in-the-hip-joint-and-lumbar-spine
#3
Kelvin J Murray, Tom Molyneux, Michael R Le Grande, Aurora Castro Mendez, Franz K Fuss, Michael F Azari
OBJECTIVE: The purpose of this study was to evaluate the correlation between mild leg length discrepancy (LLD) and degenerative joint disease (DJD) or osteoarthritis. METHODS: We evaluated standard postural lumbopelvic radiographs from 255 adults (121 women and 134 men) who had presented with spinal pain for chiropractic care. Symmetry of femoral head diameters was used to exclude magnification errors. Pearson's partial correlation was used to control for age and derive effect sizes for LLD on DJD in the hip and lower lumbar motion segments...
April 17, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28426699/anti-il-20-monoclonal-antibody-inhibited-inflammation-and-protected-against-cartilage-destruction-in-murine-models-of-osteoarthritis
#4
Yu-Hsiang Hsu, Ya-Yu Yang, Man-Hsiang Huwang, Yun-Han Weng, I-Ming Jou, Po-Tin Wu, Tain-Yu Lin, Li-Wha Wu, Ming-Shi Chang
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive destruction of articular cartilage. Interleukin (IL)-20 is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis. We investigated the role of IL-20 in OA and evaluated whether anti-IL-20 antibody (7E) treatment attenuates disease severity in murine models of surgery-induced OA. Immunohistochemical staining was used to detect IL-20 and its receptors expression in synovial tissue and cartilage from OA patients, and in OA synovial fibroblasts (OASFs) and chondrocytes (OACCs) from rodents with surgery-induced OA...
2017: PloS One
https://www.readbyqxmd.com/read/28420447/ck2-1-a-bone-morphogenetic-protein-receptor-type-ia-mimetic-peptide-repairs-cartilage-in-mice-with-destabilized-medial-meniscus
#5
Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B Kirn Safran, Anja Nohe
BACKGROUND: Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a novel bone morphogenetic protein receptor type I (BMPRI) mimetic peptide, CK2.1, that activates BMPRIa signaling in the absence of bone morphogenetic protein (BMP). Our previous research demonstrated that CK2.1 induced chondrogenesis in vitro and in vivo; however, it is unknown if CK2...
April 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28405546/arthropathy-in-dermatology-a-comprehensive-review
#6
REVIEW
Soumya Jagadeesan, Padmanabha Shenoy
Dermatology and rheumatology are two specialties that deal with significant overlap. In this context, it is important that the dermatologists acquaint themselves with conditions presenting with arthropathy. As the first step, it is essential to know whether the origin of musculoskeletal symptom is articular or extra-articular; inflammatory or noninflammatory; acute or chronic; oligo- or poly-articular. This will help in narrowing down the differential diagnoses as well as in better correlation with the cutaneous symptoms...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28398504/degenerative-inter-vertebral-disc-disease-osteochondrosis-intervertebralis-in-europe-prevalence-geographic-variation-and-radiological-correlates-in-men-and-women-aged-50-and-over
#7
Gabriele Armbrecht, Dieter Felsenberg, Melanie Ganswindt, Mark Lunt, Stephen K Kaptoge, Klaus Abendroth, Antonio Aroso Dias, Ashok K Bhalla, Jorge Cannata Andia, Jan Dequeker, Richard Eastell, Krzysztof Hoszowski, George Lyritis, Pavol Masaryk, Joyce van Meurs, Tomasz Miazgowski, Ranuccio Nuti, Gyula Poór, Inga Redlund-Johnell, David M Reid, Helmut Schatz, Christopher J Todd, Anthony D Woolf, Fernando Rivadeneira, Muhammad K Javaid, Cyrus Cooper, Alan J Silman, Terence W O'Neill, Jonathan Reeve
Objectives.: To assess the prevalences across Europe of radiological indices of degenerative inter-vertebral disc disease (DDD); and to quantify their associations with, age, sex, physical anthropometry, areal BMD (aBMD) and change in aBMD with time. Methods.: In the population-based European Prospective Osteoporosis Study, 27 age-stratified samples of men and women from across the continent aged 50+ years had standardized lateral radiographs of the lumbar and thoracic spine to evaluate the severity of DDD, using the Kellgren-Lawrence (KL) scale...
April 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28390166/application-of-navigated-ultrasound-for-assessment-of-the-anterior-pelvic-plane-in-patients-with-degenerative-hip-diseases
#8
Andrzej Kochman, Adrian Goral, Tobias Martin, Wojciech Marek, Josef Kozak, Monika Morawska-Kochman, Marek Synder
OBJECTIVES: Correct positioning of the acetabular cup is the key for successful total-hip replacement. In common clinical practice, the target alignment of the cup is defined with respect to the anterior pelvic plane. In patients with substantial anterior pelvic plane inclination, this condition may lead to inappropriate distribution of the load on the cup, as most of the forces exerted within the hip joint act along the vertical axis. With the known pelvic inclination, it is possible to readjust the position of the cup with respect to the individual posture of the patient...
April 8, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28384173/daily-oral-consumption-of-hydrolyzed-type-1-collagen-is-chondroprotective-and-anti-inflammatory-in-murine-posttraumatic-osteoarthritis
#9
Qurratul-Ain Dar, Eric M Schott, Sarah E Catheline, Robert D Maynard, Zhaoyang Liu, Fadia Kamal, Christopher W Farnsworth, John P Ketz, Robert A Mooney, Matthew J Hilton, Jennifer H Jonason, Janne Prawitt, Michael J Zuscik
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease modifying therapies. Thus, strategies that offer chondroprotective or regenerative capability represent a critical unmet need. Recently, oral consumption of a hydrolyzed type 1 collagen (hCol1) preparation has been reported to reduce pain in human OA and support a positive influence on chondrocyte function. To evaluate the tissue and cellular basis for these effects, we examined the impact of orally administered hCol1 in a model of posttraumatic OA (PTOA)...
2017: PloS One
https://www.readbyqxmd.com/read/28383601/temporomandibular-joint-involvement-in-rheumatoid-arthritis-patients-association-between-clinical-and-tomographic-data
#10
Patrícia Cf Cordeiro, Josemar P Guimaraes, Viviane A de Souza, Isabela M Dias, Jesca Nn Silva, Karina L Devito, Leticia L Bonato
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and synovial hyperplasia, which usually affects multiple joints. The temporomandibular joint (TMJ) becomes susceptible to the development of changes resulting from RA. The aim of this study was to evaluate the presence of TMD and degenerative bone changes in TMJ in patients diagnosed with RA (rheumatoid arthritis). The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/ TMD) questionnaire was used for clinical evaluation of the TMJ and for TMD classification of 49 patients of both sexes and all ages...
December 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28380089/relationship-between-articular-eminence-inclination-and-alterations-of-the-mandibular-condyle-a-cbct-study
#11
Saione Cruz Sa, Saulo Leonardo Sousa Melo, Daniela Pita de Melo, Deborah Queiroz Freitas, Paulo Sérgio Flores Campos
This study aimed at verifying the correlation among angulation of the articular eminence (AE), shape of the condyle and its degenerative bone diseases (DBDs), according to age and sex, through Cone Beam Computed Tomography (CBCT). Five hundred and twenty-eight temporomandibular joints (TMJ) were evaluated. The condyles were classified as: flat, convex, angled and rounded, and the AE angulation was measured. The DBDs evaluated were osteophytes, flattening, erosion, subcortical cysts and spinal sclerosis. There was no difference in the mean angulations in relation to age group (p>0...
March 30, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28379175/enumeration-and-localization-of-mesenchymal-progenitor-cells-and-macrophages-in-synovium-from-normal-individuals-and-patients-with-pre-osteoarthritis-or-clinically-diagnosed-osteoarthritis
#12
Kate O'Brien, Pankaj Tailor, Catherine Leonard, Lisa M DiFrancesco, David A Hart, John R Matyas, Cyril B Frank, Roman J Krawetz
Osteoarthritis (OA) is a degenerative disorder characterized by chondrocyte apoptosis and degeneration of articular cartilage resulting in loss of mobility and pain. Inflammation plays a key role in the development and progression of OA both on the side of apoptosis and repair, while its exact role in pathogenesis has yet to be fully elucidated. Few studies have examined the cellular composition (inflammatory cells and/or progenitor cells) in the synovium of patients with pre-OA (asymptomatic with cartilage damage)...
April 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28372297/chitosan-a-promising-polymer-for-cartilage-repair-and-viscosupplementation
#13
Fanny Comblain, Guillem Rocasalbas, Sandrine Gauthier, Yves Henrotin
Osteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments are limited to symptoms alleviation. There is a need for a new efficient and safe treatment. Viscosupplementation is a process that aims to restore the normal rheological properties of synovial fluid. For the past years, hyaluronic acid was usually used but this molecule has some limitations including the short residency time in joint cavity...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28366524/advanced-hip-osteoarthritis-causing-autonomic-dysreflexia-and%C3%A2-severe-spasticity-in-a-patient-with-spinal-cord-injury-a-case-report
#14
Brittany Bickelhaupt, Megan Richard, Michelle Trbovich
The life expectancy of persons with spinal cord injury (SCI) is increasing due to advances in medicine and technology. As a result, there is a higher incidence of age-associated illnesses in this population. Degenerative joint disease is a common age-associated illness that causes pain and thus, in persons with SCI above the T6 level, can serve as a noxious stimulus to trigger autonomic dysreflexia (AD). This is a case report of severe bilateral hip osteoarthritis (OA) causing unyielding AD in a person with tetraplegia leading to bilateral girdle stone surgeries...
March 31, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28365462/toward-understanding-the-role-of-cartilage-particulates-in-synovial-inflammation
#15
A M Silverstein, R M Stefani, E Sobczak, E L Tong, M G Attur, R P Shah, J C Bulinski, G A Ateshian, C T Hung
OBJECTIVE: Arthroscopy with lavage and synovectomy can remove tissue debris from the joint space and the synovial lining to provide pain relief to patients with osteoarthritis (OA). Here, we developed an in vitro model to study the interaction of cartilage wear particles with fibroblast-like synoviocytes (FLS) to better understand the interplay of cartilage particulates with cytokines on cells of the synovium. METHOD: In this study sub-10 μm cartilage particles or 1 μm latex particles were co-cultured with FLS ±10 ng/mL interleukin-1α (IL-1α) or tumor necrosis factor-α (TNF-α)...
March 30, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28364187/chrysin-attenuates-il-1%C3%AE-induced-expression-of-inflammatory-mediators-by-suppressing-nf-%C3%AE%C2%BAb-in-human-osteoarthritis-chondrocytes
#16
Wenhao Zheng, Zhenyu Tao, Leyi Cai, Chunhui Chen, Chuanxu Zhang, Quan Wang, Xiaozhou Ying, Wei Hu, Hua Chen
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Chrysin, a natural flavonoid extracted from honey and propolis, has been reported to have anti-inflammatory effects. However, the anti-inflammatory effects of chrysin on OA have not been reported. This study aimed to assess the effects of chrysin on human OA chondrocytes. Human OA chondrocytes were pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β for 24 h. Production of NO, PGE2, MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 was evaluated by the Griess reaction and ELISAs...
March 31, 2017: Inflammation
https://www.readbyqxmd.com/read/28362543/a-botanical-composition-mitigates-cartilage-degradations-and-pain-sensitivity-in-osteoarthritis-disease-model
#17
Mesfin Yimam, Young-Chul Lee, Laura Wright, Ping Jiao, Teresa Horm, Mei Hong, Lidia Brownell, Qi Jia
Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive articular cartilage degradation manifested with significant functional impairment in consort with signs and symptoms of inflammation, stiffness, and loss of mobility. Current OA management is inadequate due to the lack of nominal therapies proven to be effective in hampering disease progression where symptomatic therapy focused intervention masks the primary etiology leading to irreversible structural damage. In this study, we describe the effect of UP1306, a composition containing a proprietary blend of two standardized extracts from the heartwood of Acacia catechu and the root bark of Morus alba, in maintaining joint structural integrity and alleviating OA associated symptoms in monosodium-iodoacetate (MIA)-induced rat OA disease model...
March 31, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28358604/infundibular-pulmonic-stenosis-in-a-moluccan-cockatoo-cacatua-moluccensis
#18
Graham Zoller, David Sanchez-Migallon Guzman, Noémie Summa, Krista A Keller, Sarah J Silverman, Joshua A Stern
A 31-year-old female Moluccan cockatoo (Cacatua moluccensis) was examined for intermittent foot clenching of 4 months' duration. Physical examination revealed feather-destructive behavior and clinical findings compatible with hypovitaminosis A. Neurologic examination was unremarkable. Results of radiographs, hematologic testing, plasma biochemical analyses, and measurement of lead and trace element blood concentrations were unremarkable, except for degenerative joint disease of several thoracic intervertebral joints and a low blood copper concentration...
March 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28347649/the-effect-of-intraarticular-serum-rich-in-growth-factors-srgf-on-knee-osteoarthritis-in-the-rat-model
#19
Shahrzad Azizi, Reza Kheirandish, Alireza Farsinejad, Najmeh Rasouli
Osteoarthritis (OA) is a degenerative joint disease with high incidence in world. Various treatments have been used for decreasing pain and improving physical function without clearly beneficial evidences. Nowadays, platelet-rich therapy is used as a novel approach in field of regenerative medicine. The present study evaluated the effect of intraarticular serum rich in growth factors (SRGF) on the monosodium iodoacetate induced-osteoarthritis in rat model. SRGF was injected 3 times weekly. Femorotibial joints were examined 2 weeks after last injection...
March 12, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28345356/dysregulation-of-tissue-factor-thrombin-activatable-fibrinolysis-inhibitor-and-fibrinogen-in-patients-undergoing-total-joint-arthroplasty
#20
Christopher Wanderling, Jeffrey Liles, Elissa Finkler, Peter Carlsgaard, William Hopkinson, Nil Guler, Debra Hoppensteadt, Jawed Fareed
Total joint arthroplasty (TJA) of the hip or knee (THA, TKA) has become an increasingly common procedure. While TJA is a successful treatment for individuals experiencing degenerative joint diseases, it is well known that one of the most common perioperative complications of TJA is deep venous thrombosis (DVT). To profile tissue factor (TF), microparticle-tissue factor (MP-TF), thrombin-activatable fibrinolysis inhibitor (TAFI), and fibrinogen levels in patients undergoing TJA to determine potential preexisting Hemostatic dysregulation...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
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