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Degenerative joint disease

Kousei Miura, Masao Koda, Masaki Tatsumura, Itsuo Shiina, Takeo Mammoto, Atsushi Hirano, Tetsuya Abe, Toru Funayama, Hiroshi Noguchi, Masashi Yamazaki
Charcot spinal arthropathy (CSA) is a rare spinal disorder presenting neuropathic osteoarthropathy of facet joints leading to progressive destruction. After L4-5 PLIF, a 63-year-old woman with Parkinson's disease (PD) underwent L3-4 and L5-S1 PLIF for primary adjacent segment disease caused by degenerative change, which was found as facet joint osteophytes and a vacuum disc phenomenon with endplate sclerosis. However, her postural disorder from PD deteriorated, and strong opioid analgesics were administered for severe recurring low back pain...
November 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Jerome Nicolas Janssen, Sarah Batschkus, Stefan Schimmel, Christa Bode, Boris Schminke, Nicolai Miosge
Osteoarthritis (OA) is the most common chronic joint disease and leads to the degradation of the extracellular matrix by an imbalance between anabolic and catabolic processes. TGF-β3 (transforming growth factor beta-3) and epidermal growth factor (EGF) influence the osteochondrogenic potential of chondrocytes. In this study, we compared the expression of mediators and receptors in the TGF-β3 and EGF pathways, as well as biglycan (BGN), in healthy and diseased chondrocytes. Furthermore, we used chondrogenic progenitor cells (CPCs) for in vitro stimulation and knockdown experiments to elucidate the effects of TGF-β3 and EGF on the chondrogenic potential...
November 15, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
Raija Vainionpää, Tommi Kinnunen, Paula Pesonen, Marja-Liisa Laitala, Vuokko Anttonen, Kirsi Sipilä
OBJECTIVE: The aim of the present study was to evaluate the prevalence of self-reported temporomandibular disorders (TMD) symptoms and clinically diagnosed TMD among Finnish prisoners. MATERIAL AND METHODS: Altogether 100 prisoners from the Pelso Prison, Vaala, Finland, underwent dental and TMD clinical examinations performed by a calibrated and well-trained dentist. Symptom Questionnaire and clinical examination according to a Finnish pre-final version of the DC/TMD (Diagnostic Criteria for Temporomandibular Disorders) Axis I protocol were used to evaluate the prevalence of TMD sub-diagnoses...
November 15, 2018: Acta Odontologica Scandinavica
Imene Ksibi, Wafa Aissi, Anja Mghirbi, Najla Mouhli, S Rekik, Rim Dhahri, Leila Métoui, Imen Gharsallah, W Kessomtini, Rim Maaoui, Hajer Rahali Khachlouf
INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease in the elderly. The often multifocal location at this age can be a source of pain, limitation of everyday activities, thus affecting their quality of life. AIM: To evaluate functional status of aged people with generalized OA in Tunisia, and to detect the main factors associated with a poor function in order to optimize their medical care. METHODS: A cross-sectional, descriptive study done between January and March 2017...
June 2018: La Tunisie Médicale
Abdelhafeez Moshrif, Jean Denis Laredo, Hassan Bassiouni, Mohamed Abdelkareem, Pascal Richette, Matthieu Reshe Rigon, Thomas Bardin
BACKGROUND: Calcium pyrophosphate dihydrate deposition disease (CPPD) has been reported to involve the spine, but few systematic studies have been published. OBJECTIVE: To further characterize the spinal involvement with CPPD by a review of CPPD patients hospitalized in a rheumatology department. METHODS: We retrospectively reviewed data for patients consecutively admitted with a diagnosis of CPPD in the rheumatology department of Lariboisière hospital in Paris, France over 5 years by using a standardized protocol and electronic case report forms...
October 14, 2018: Seminars in Arthritis and Rheumatism
Attila Szatmári, Balázs Benedek, Tamás Perlaky, Krisztián Szalay, Imre Sallai, Gábor Skaliczki, Miklós Szendrői, Imre Antal
INTRODUCTION: Several methods (bone graft, endoprosthesis) are used to reconstruct proximal humerus resections due to primary and metastatic tumours. One of the new procedures is the replacement of the joint surfaces and the removed proximal humerus end with reverse shoulder prosthesis, optionally supplemented with bone implantation (composite procedure) in the hope of achieving better shoulder function. AIM: The aim of this study was to compare the shoulder function of the patient group operated by the above procedure with reverse prosthesis to a patient group operated by indication of degenerative shoulder disease (rotator cuff arthropathy)...
November 2018: Orvosi Hetilap
I V Volkov, I Sh Karabaev, D A Ptashnikov, N A Konovalov, V V Khlebov
Postoperative pain accompanies up to 20% of interventions for degenerative spine diseases (DSDs). The epidemiologic data are contradictory; clinical and radiological diagnostics is often low efficient; capabilities of interventional diagnosis and treatment techniques are poorly understood. PURPOSE: The study purpose was to investigate the structure of pain syndromes after surgery for DSDs of the lumbar spine, based on complex diagnostics, as well as to evaluate the capabilities of interventional treatment...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Maria De Santis, Berardo Di Matteo, Emanuele Chisari, Gilberto Cincinelli, Peter Angele, Christian Lattermann, Giuseppe Filardo, Nicolò Danilo Vitale, Carlo Selmi, Elizaveta Kon
Introduction: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral damage, and bone remodelling, affecting most commonly weight-bearing joints, such as the knee and hip. The loss of cartilage leads to joint space narrowing, pain, and loss of function which could ultimately require total joint replacement. The Wnt/ β catenin pathway is involved in the pathophysiology of OA and has been proposed as a therapeutic target. Endogenous and pharmacological inhibitors of this pathway were recently investigated within innovative therapies including the use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs)...
2018: BioMed Research International
Zhi-Feng Xiao, Guo-Yi Su, Yu Hou, Shu-Dong Chen, Ding-Kun Lin
Osteoarthritis (OA) is one of the most common degenerative disease which causes pain and disability of joint and brings heavy socioeconomic burden in the world. However, the pathogenesis of OA has not been fully understood. Articular cartilage degradation or loss was often regarded as the characteristic of osteoarthritis. But we believe that there may had a illusion that OA was simply considered to be a process of wear and tear because evidences have supported all joint tissues remodeling including cartilage, subchondral bone, synovium, ligament, fat pad, and etc, were engaged in OA, in particular the cartilage and subchondral bone...
December 2018: Medical Hypotheses
Xiaoping Mu, Jianxun Wei, Chenglong Wang, Yufu Ou, Dong Yin, Bin Liang, Dezan Qiu, Zhuhai Li
STUDY DESIGN: A single-center, placebo-controlled, randomized design. OBJECTIVE: The current study investigated the effects of intravenous and topical administrations of Tranexamic acid (TXA) on the visible and hidden blood loss of patients receiving posterior lumbar interbody fusion (PLIF). SUMMARY: of Background Data: TXA significantly reduces the visible and hidden blood loss associated with joint replacement. At present, many studies have examined the safety and effectiveness of the intravenous or topical administration of TXA after posterior lumbar surgery...
November 1, 2018: World Neurosurgery
P J Cope, K Ourradi, Y Li, M Sharif
Osteoarthritis (OA) is a chronic degenerative disease of diarthrodial joints most commonly affecting people over the age of forty. The causes of OA are still unknown and there is much debate in the literature as to the exact sequence of events that trigger the onset of the heterogeneous disease we recognise as OA. There is currently no consensus model for OA that naturally reflects human disease. Existing ex-vivo models do not incorporate the important inter-tissue communication between joint components required for disease progression and differences in size, anatomy, histology and biomechanics between different animal models makes translation to the human model very difficult...
October 25, 2018: Osteoarthritis and Cartilage
Zekai Lu, Min Luo, Yongpan Huang
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) is a complex chronic degenerative joint disease involving oxidative stress, inflammation, and apoptosis of chondrocytes. As decoys of micro RNAs, long non-coding RNAs (lncRNAs) play important roles in various biological processes. This study was designed to investigate the interactions between lncRNA-CIR, chondrocyte apoptosis, and the molecular mechanisms underlying OA. METHODS: Primary cultured chondrocytes were stressed using H2 O2 , IL-1β, or TNF-ɑ to simulate conditions found in OA...
November 2, 2018: Journal of Cellular Biochemistry
Dong-Sik Chae, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Chong-Hyuk Choi, Seahyoung Lee, Ki-Chul Hwang
BACKGROUND: Osteoarthritis (OA) can be defined as degradation of articular cartilage of the joint, and is the most common degenerative disease. To regenerate the damaged cartilage, different experimental approaches including stem cell therapy have been tried. One of the major limitations of stem cell therapy is the poor post-transplantation survival of the stem cells. Anoikis, where insufficient matrix support and adhesion to extracellular matrix causes apoptotic cell death, is one of the main causes of the low post-transplantation survival rate of stem cells...
November 1, 2018: Biological Research
Saima Hilal, M Arfan Ikram, Marcel M Verbeek, Oscar H Franco, Erik Stoops, Hugo Vanderstichele, Wiro J Niessen, Meike W Vernooij
Background and Purpose- Inflammation is involved in the pathogenesis of large artery atherosclerosis, ischemic stroke, and Alzheimer dementia. However, the role of inflammation in cerebral small vessel disease and neurodegeneration remains poorly understood. We hypothesize that CRP (C-reactive protein) is associated with brain structural changes and may interact with amyloid to produce vascular and degenerative damage. We examined the association of CRP levels with imaging markers of cerebral small vessel disease and neurodegeneration...
November 2018: Stroke; a Journal of Cerebral Circulation
Nisha N Shah, Marcus P Richardson, Anson K Chu, Christopher F Hyer
The development of hallux interphalangeal joint (IPJ) arthritis after an arthrodesis of the first metatarsophalangeal joint has been established in the literature. However, the significance has not been well reported. A retrospective, radiographic review of patients who had undergone a first metatarsophalangeal joint arthrodesis was performed. The Coughlin classification for degree of arthritic degeneration, hallux abductus angle, and hallux interphalangeus angle were measured in 107 radiographs of 103 patients preoperatively and postoperatively...
October 20, 2018: Foot & Ankle Specialist
A Corradini, G Campochiaro, M Gialdini, M Rebuzzi, P Baudi
PURPOSE: Glenoid fractures occur as a result of direct impact of the humeral head against the glenoid rim following high-energy trauma. They frequently involve one-third of the glenoid surface with an oblique fracture rim from 2 to 6-7 o'clock, and they must not be confused with bony Bankart lesions. In medium-age patients, they are frequently associated with acute cuff tear while in older patients with chronic cuff tear: These conditions increase the instability of the shoulder if not treated...
October 2018: Musculoskeletal Surgery
Jun Wang, Yin Wang, Hui Zhang, Ming Lu, Weilu Gao, Li Yin, Zongsheng Yin
INTRODUCTION: Osteoarthritis is a common degenerative joint disease that eventually leads to disability and poor quality of life. The main symptoms are joint pain and mobility disorders. If the patient has severe pain or other analgesics are contraindicated, opioids may be a viable treatment option. To evaluate and compare the efficacy and safety of opioids in the treatment of knee or hip osteoarthritis, we will integrate direct and indirect evidence using a Bayesian network meta-analysis to establish hierarchies of these drugs...
October 18, 2018: BMJ Open
L Bause
The introduction of biologics has led to a great improvement in the treatment options for inflammatory rheumatic diseases. Nevertheless, surgical interventions are still necessary in many patients but a change in surgical indications could be observed. The previously predominant synovectomy of inflamed rheumatic joints is now reduced to a few so-called rebellious joints with persistent inflammation. Joint-preservation and tenoplasty are standard surgical procedures requiring a specific approach including potential complications...
November 2018: Der Orthopäde
Aifeng Liu, Ping Wang, Juntao Zhang, Wenhao Ye, Qiang Wei
Osteoarthritis (OA) is an unavoidable degenerative disease of the human body. A relatively efficient and desirable treatment exists that leads to the ecological restoration of cartilage through the adjustments of the micro-environment of the human body and relies on its self-repairing ability. In the present study, lubricants were injected into the knee joints of rats. Hyaluronic acid (HA) reinforced with graphene oxide (GO) provided a lubricating condition for cartilage repair, as well as played an important role in the regulation of the microenvironment in the joint cavity...
January 1, 2019: Journal of Nanoscience and Nanotechnology
Dawoon Baek, Kyoung-Mi Lee, Ki Won Park, Jae Wan Suh, Seong Mi Choi, Kwang Hwan Park, Jin Woo Lee, Sung-Hwan Kim
Traumatic and degenerative lesions of articular cartilage usually progress to osteoarthritis (OA), a leading cause of disability in humans. MicroRNAs (miRNAs) can regulate the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) and play important roles in the expression of genes related to OA. However, their functional roles in OA remain poorly understood. Here, we have examined miR-449a, which targets sirtuin 1 (SIRT1) and lymphoid enhancer-binding factor-1 (LEF-1), and observed its effects on damaged cartilage...
September 27, 2018: Molecular Therapy. Nucleic Acids
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