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Degenerative joint disease

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https://www.readbyqxmd.com/read/28812968/jnk-pathway-in-osteoarthritis-pathological-and-therapeutic-aspects
#1
Hong-Xing Ge, Fu-Man Zou, Yan Li, An-Min Liu, Min Tu
CONTEXT: Osteoarthritis (OA) is a common chronic degenerative joint disease resulting in physical disability and reduced quality of life. Different biochemical signaling pathways are involved in the progression of OA, including the c-Jun NH2-terminal kinase (JNK) signal transduction pathway. OBJECTIVE: In this study, we have reviewed the recent updates on the association of JNK pathway with OA. METHODS: In this review, we have explored the databases like PubMed, Google Scholar, Medline, Scopus, etc...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28810805/hindfoot-arthritis-progression-and-arthrodesis-risk-after-total-ankle-replacement
#2
Travis J Dekker, David Walton, Emily N Vinson, Kamran S Hamid, Andrew E Federer, Mark E Easley, James K DeOrio, James A Nunley, Samuel B Adams
BACKGROUND: The purpose of this study was to assess the radiographic progression of subtalar and talonavicular degenerative joint disease in a series of patients who had undergone TAA (total ankle arthroplasty) with minimum follow-up of 5 years. METHODS: TAA patient radiographs from a single institution were analyzed for peritalar arthritic changes by extrapolating the modified Kellgren Lawrence (KL) grades of the knee to the subtalar and talonavicular joints. Patients were included if they had a minimum of 5 years of follow-up...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28810001/deferoxamine-synergizes-with-transforming-growth-factor-%C3%AE-signaling-in-chondrogenesis
#3
Zheng Huang, Guangxu He, Yanke Huang
Osteoarthritis, also known as degenerative arthritis or degenerative joint disease, is an epidemic disease that affects millions of people worldwide. Despite extensive recent work on the cellular biology of osteoarthritis, the precise mechanisms involved are still poorly understood and there is no effective treatment for this disease. The role of transforming growth factor-beta (TGF-β) in promoting chondrogenesis and inducing the expression of cartilage-specific extracellular matrix molecules to form cartilage is well-established...
August 14, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28798097/suramin-inhibits-osteoarthritic-cartilage-degradation-by-increasing-extracellular-levels-of-chondroprotective-tissue-inhibitor-of-metalloproteinases-3-timp-3
#4
Anastasios Chanalaris, Christine Doherty, Brian D Marsden, Gabriel Bambridge, Stephen P Wren, Hideaki Nagase, Linda Troeberg
Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available. Attempts to treat the disease with small molecule inhibitors of the metalloproteinases that degrade the cartilage matrix have been hampered by a lack of specificity. We aimed to inhibit cartilage degradation by augmenting levels of the endogenous metalloproteinase inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP-3), through blocking its interaction with the endocytic scavenger receptor, low-density lipoprotein receptor-related protein 1 (LRP1)...
August 10, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28797511/conditions-simulating-primary-bone-neoplasms
#5
REVIEW
Jodi M Carter, Benjamin Matthew Howe, Carrie Y Inwards
A number of nonneoplastic conditions can mimic tumors of bone. Some of the more common mimics of primary bone tumors include infectious, inflammatory, periosteal, and degenerative joint disease-associated lesions that produce tumorlike bone surface-based or intraosseous lesions. This article considers a spectrum of reactive and nonreactive processes including stress fracture, subchondral cysts, osteonecrosis, heterotopic ossification, osteomyelitis, sarcoidosis, and amyloidoma that can present in such a way that they are mistaken for a tumor arising primary in bone...
September 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28782076/shoulder-arthroplasty-in-patients-with-osteo-chondrodysplasias
#6
Bradley Schoch, Jean-David Werthel, Joaquin Sanchez-Sotelo, John W Sperling, Robert H Cofield, Mark Morrey
PURPOSE: Osteo-chondrodysplasias are a rare cause of limb malalignment, deformity and degenerative joint disease. Earlier in life, deformities may be managed with bony realignment and soft tissue releases; however, as degenerative changes progress, arthroplasty may be considered. There are limited reports examining shoulder arthroplasty in this population. This study aims to assess pain relief, function, and re-operation rate of shoulder arthroplasty in patients with osteo-chondrodysplasias...
August 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28777012/association-of-common-variants-in-tgfa-with-increased-risk-of-knee-osteoarthritis-susceptibility
#7
Guofeng Cui, Rong Wei, Dan Liu, Haojie Yang, Junlong Wu, Lihong Fan, Kunzheng Wang
OBJECTIVE: Osteoarthritis (OA) is a complex degenerative joint disorder, which has contributions from both environmental and genetic factors. Several recent publications have established the connection between hip OA susceptibility and genetic markers within the TGFA gene, however, the relationship of these markers with knee OA has not been elucidated. Therefore, the present study was designed to investigate the potential linkage between common variants of the TGFA gene with knee OA in a large sample of Han Chinese individuals...
August 4, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28770522/hoffa-s-fat-pad-abnormality-in-the-development-of-knee-osteoarthritis
#8
Wojciech Paduszyński, Mateusz Jeśkiewicz, Paweł Uchański, Sebastian Gackowski, Marek Radkowski, Urszula Demkow
Over the past two decades, many hypotheses have been put forward to explain the cause of knee osteoarthritis. Scientific reports bring up the role of adipose tissue in the activation of the inflammatory mechanisms, which is a characteristic feature of osteoarthritis natural history. Adipose tissue produces and releases cytokines, interleukins, and growth factors by means of paracrine, endocrine, and autocrine mechanisms. Hoffa's fat pad (infrapatellar adipose tissue) plays a viable role in the initiation and progression of osteoarthritis due to its role in the activation and release of pro-inflammatory mediators...
August 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28765881/identification-of-differentially-expressed-micrornas-in-knee-anterior-cruciate-ligament-tissues-surgically-removed-from-patients-with-osteoarthritis
#9
Bin Li, Lunhao Bai, Peng Shen, Yue Sun, Zhizuo Chen, Yu Wen
The degradation of cruciate ligaments is frequently observed in degenerative joint diseases, such as osteo-arthritis (OA). The present study aimed to identify the differentially expressed microRNAs (miRNAs or miRs) in knee anterior cruciate ligament (ACL) tissues derived from patients with OA and in health subjects (non-OA). By using Affymetrix miRNA 4.0 microarrays, a total of 22 miRNAs (including let-7f-5p, miR-26b-5p and miR-146a-5p) were found to be upregulated, while 17 (including miR-18a-3p, miR-138-5p and miR-485-3p) were downregulated in the osteoarthritic ACL tissues (fold change ≥2, P-value <0...
July 31, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28764702/characterisation-of-the-correlation-between-standing-lordosis-and-degenerative-joint-disease-in-the-lower-lumbar-spine-in-women-and-men-a-radiographic-study
#10
Kelvin J Murray, Michael R Le Grande, Arantxa Ortega de Mues, Michael F Azari
BACKGROUND: Degenerative joint disease (DJD) in the lumbar spine is a common condition that is associated with chronic low back pain. Excessive loading of lumbar joints is a risk factor for DJD. Changes in lumbar lordosis significantly redistribute the forces of weight-bearing on the facet joints and the intervertebral discs. However, the relationship between lumbar lordosis and DJD has not been characterized in men and women. METHODS: We characterised the correlation between standing lumbar lordosis and DJD in standing radiographic images from 301 adult female and male chiropractic patients...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28764284/efficacy-of-bromelain-along-with-trypsin-rutoside-trihydrate-enzymes-and-diclofenac-sodium-combination-therapy-for-the-treatment-of-tmj-osteoarthritis-a-randomised-clinical-trial
#11
S Jayachandran, Priyanka Khobre
INTRODUCTION: Osteoarthritis (OA) is a degenerative disorder characterized by chronic inflammatory response of cartilage and articular surface involving Temporomandibular Joint (TMJ). Pain as one of the major symptom of osteoarthritis affects the quality of life and is usually managed by Non Steroidal Anti Inflammatory Drugs (NSAIDs) such as diclofenac sodium. Bromelain, trypsin and rutoside trihydrate formulation can be used to treat this disease because of anti-inflammatory and anti-oxidant effects...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763118/mechanical-stimulation-of-mesenchymal-stem-cells-implications-for-cartilage-tissue-engineering
#12
REVIEW
Niamh Fahy, Mauro Alini, Martin J Stoddart
Articular cartilage is a load-bearing tissue playing a crucial mechanical role in diarthrodial joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical stimuli in the development of cartilage and maintenance of chondrocyte phenotype in adult tissues has been well documented. Furthermore, dysregulated loading is associated with cartilage pathology highlighting the importance of mechanical cues in cartilage homeostasis. The repair of damaged articular cartilage resulting from trauma or degenerative joint disease poses a major challenge due to a low intrinsic capacity of cartilage for self-renewal, attributable to its avascular nature...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28761983/effect-of-mechanical-loading-on-the-metabolic-activity-of-cells-in-the-temporomandibular-joint-a-systematic-review
#13
REVIEW
Beatriz F Betti, Vincent Everts, Johannes C F Ket, Hessam Tabeian, Astrid D Bakker, Geerling E Langenbach, Frank Lobbezoo
OBJECTIVES: The purpose of this systematic review was to elucidate how different modalities and intensities of mechanical loading affect the metabolic activity of cells within the fibro-cartilage of the temporomandibular joint (TMJ). MATERIALS AND METHODS: A systematic review was conducted according to PRISMA guidelines using PubMed, Embase, and Web of Science databases. The articles were selected following a priori formulated inclusion criteria (viz., in vivo and in vitro studies, mechanical loading experiments on TMJ, and the response of the TMJ)...
August 1, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28761275/efficacy-of-arthrocentesis-versus-arthrocentesis-with-sodium-hyaluronic-acid-in-temporomandibular-joint-osteoarthritis-a-comparison
#14
Tikaram Gurung, R K Singh, Shadab Mohammad, U S Pal, Abbas Ali Mahdi, Manoj Kumar
INTRODUCTION: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease characterized by deterioration of articular tissue with concomitant osseous changes in the condyle and/or articular eminence, joint positive for TMJ noise with jaw movement or function, crepitus detected on palpation on opening, closing, right/left lateral, or protrusive movement. Hyaluronic acid (HA) is a polysaccharide of the family of glycosaminoglycans. HA has been shown to improve and restore normal lubrication in joint, provide nutrition to the avascular articulating disc, and stabilize the joint...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28758960/ultrasound-for-early-detection-of-joint-disease-in-patients-with-hemophilic-arthropathy
#15
REVIEW
Matteo Nicola Dario Di Minno, Gianluigi Pasta, Sonia Airaldi, Federico Zaottini, Antonio Storino, Ernesto Cimino, Carlo Martinoli
Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-negligible percentage of patients develop degenerative changes in their joints despite this type of treatment. Thus, periodic monitoring of the joint status in hemophilia patients has been recommended to identify early arthropathic changes and prevent the development or progression of hemophilic arthropathy...
July 31, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28747871/age-and-glaucoma-related-characteristics-in-retinal-nerve-fiber-layer-and-choroid-localized-morphometrics-and-visualization-using-functional-shapes-registration
#16
Sieun Lee, Morgan L Heisler, Karteek Popuri, Nicolas Charon, Benjamin Charlier, Alain Trouvé, Paul J Mackenzie, Marinko V Sarunic, Mirza Faisal Beg
Optical coherence tomography provides high-resolution 3D imaging of the posterior segment of the eye. However, quantitative morphological analysis, particularly relevant in retinal degenerative diseases such as glaucoma, has been confined to simple sectorization and averaging with limited spatial sensitivity for detection of clinical markers. In this paper, we present point-wise analysis and visualization of the retinal nerve fiber layer and choroid from cross-sectional data using functional shapes (fshape) registration...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28747096/preliminary-description-of-aging-cats-and-dogs-presented-to-a-new-zealand-first-opinion-veterinary-clinic-at-end-of-life
#17
M C Gates, H J Hinds, A Dale
AIMS: To conduct a preliminary investigation into the chronic disease conditions and clinical signs present in aging New Zealand companion animals at end-of-life and to describe the timing, circumstances, and manner of death. METHODS: The medical records database of a first opinion, companion animal, veterinary practice in Auckland, New Zealand was searched to identify all canine and feline patients ≥7 years of age that were subjected to euthanasia and/or cremated in the period between July 2012-June 2014...
July 26, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28730147/correlation-between-pain-and-degenerative-bony-changes-on-cone-beam-computed-tomography-images-of-temporomandibular-joints
#18
SunMee Bae, Moon-Soo Park, Jin-Woo Han, Young-Jun Kim
BACKGROUND: The aim of this study was to assess correlation between pain and degenerative bony changes on cone-beam computed tomography (CBCT) images of temporomandibular joints (TMJs). METHODS: Two hundred eighty-three temporomandibular joints with degenerative bony changes were evaluated. Pain intensity (numeric rating scale, NRS) and pain duration in patients with degenerative joint disease (DJD) were also analyzed. We classified condylar bony changes on CBCT into five types: osteophyte (Osp), erosion (Ero), flattening (Fla), subchondral sclerosis (Scl), and pseudocyst (Pse)...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28725502/universal-2-wrist-arthroplasty-in-rheumatoid-arthritis
#19
Sandra Pfanner, Giovanni Munz, Giulia Guidi, Massimo Ceruso
Purpose  The aim of this study was to evaluate the mid- to long-term outcomes and complications in patients affected by rheumatic diseases treated with the Universal 2 (U2) total wrist arthroplasty (TWA). Methods  We reviewed, in a retrospective, noncontrolled cohort study, 22 patients affected by rheumatoid arthritis (RA), who underwent U2 total wrist replacement between March 2003 and January 2014 for the treatment of 23 rheumatoid wrists with the aim of obtaining the remission of pain and a range of motion (ROM) useful for daily activities, according to the patients' demands, as an alternative to total wrist arthrodesis...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28706805/arthroscopic-intra-articular-disk-excision-of-the-sternoclavicular-joint
#20
Graham Tytherleigh-Strong, Abbas Rashid, Christopher Lawrence, David Morrissey
The sternoclavicular joint (SCJ) has a complete intra-articular disk that can be damaged either as a result of trauma or as part of ongoing degenerative joint disease. Although often asymptomatic, SCJ disk tears may lead to mechanical symptoms and pain. Previously, isolated symptomatic SCJ disk tears have only occasionally been mentioned in the literature with a few associated case reports of diskectomy by open arthrotomy. With improved imaging and availability of magnetic resonance imaging scans and the advent of SCJ arthroscopy it is now possible to treat symptomatic SCJ disk tears by arthroscopic excision...
June 2017: Arthroscopy Techniques
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