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Degenerative joint disease

Troy J Boffeli, Rachel C Collier, Katherine R Schnell
Lisfranc fracture-dislocations can be devastating injuries with significant long-term sequelae with or without surgical intervention. The main goal of treatment is to minimize the common long-term complications including pain, progressive arch collapse, degenerative joint disease, hardware failure, and reoperation. Partial primary fusion involving the first, second, and third tarsometatarsal joints has become a common approach for primarily dislocation injuries, with open reduction and internal fixation (ORIF) favored for Lisfranc injuries involving fracture...
September 19, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Zekai Mao, Pengcheng Wang, Qiyong Pan, Xiaojian Huang, Rui Zhang, Xiaobin Shang, Xiaohu Ma, Hongbo You
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage degradation driven by proinflammatory cytokines; meanwhile, statins display anti-inflammatory effects. Here we assessed the effects of pravastatin on inflammatory rat chondrocytes and explored the underlying mechanism. METHODS: Rat articular chondrocytes were pretreated with pravastatin and subsequently stimulated with IL-1β. Then, the expression levels of OA- and autophagy-related effectors, at the mRNA and protein levels, were examined by real-time polymerase chain reaction (RT-PCR) and Western blotting, respectively...
September 19, 2018: International Immunopharmacology
Stig Storgaard Jakobsen, Søren Overgaard, Kjeld Søballe, Ole Ovesen, Bjarne Mygind-Klavsen, Christian Andreas Dippmann, Michael Ulrich Jensen, Jens Stürup, Jens Retpen
Hip pain is highly prevalent in both the younger and the elderly population. In older patients, pain arising from osteoarthritis (OA) is most frequent, whereas in younger patients, non-degenerative diseases are more often the cause of pain. The pain may be caused by hip dysplasia and femoroacetabular impingement (FAI).Abnormal mechanics of the hip are hypothesized by some authors to cause up to 80% of OA in the hip. Therefore, correction of these abnormalities is of obvious importance when treating young patients with hip pain...
July 2018: EFORT Open Reviews
V Tékus, É Borbély, T Kiss, A Perkecz, Á Kemény, J Horváth, A Kvarda, E Pintér
Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative process of the articular cartilage associated with hypertrophic changes in the bone. The aim of the present study was to investigate the anti-inflammatory and analgesic effects of Hévíz thermal water and mud in monosodium iodoacetate- (MIA-) (25 mg/ml, 20 μ l i.a.) induced osteoarthritis and Complete Freund's adjuvant- (CFA-) (1 mg/ml, 50-50  μ l s...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Tao Wu, Zhaohong Shi, Haixin Song, Yangzheng Li, Jian-Hua Li
Local anesthetics (LAs) are commonly used to provide peri-operative pain control in the peripheral joints. In the field of regenerative medicine, adipose-derived mesenchymal stem cells (ADMSCs) are gaining attention as a cellular source for repair and regeneration in degenerative diseases. However, previous studies have demonstrated that the commonly used drugs lidocaine, ropivacaine, bupivacaine and mepivacaine may be toxic to human chondrocytes, which has raised concerns over whether they exert similar negative effects on ADMSCs during early chondrogenic differentiation...
October 2018: Experimental and Therapeutic Medicine
Robert Ravinsky, James Rofaiel, Benjamin G Escott, Zachary Lim, Bheeshma Ravi, Andrew Howard
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a well-characterized disorder of the hip seen in adolescent patients. It is characterized by deformity secondary to failure through the proximal femoral growth plate, which results in posterior-inferior displacement of the epiphysis on the proximal femoral metaphysis. Long-term sequelae of SCFE may include osteonecrosis, residual deformity, leg length discrepancy, degenerative joint disease, and chronic pain. The long-term consequences of SCFE may be the source of significant morbidity for the patient, and depending of the local incidence of this condition, may represent a significant expenditure of health care resources...
September 7, 2018: Journal of Pediatric Orthopedics
Sahar Dehghani, Elham Alipoor, Ahmad Salimzadeh, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND: Osteoarthritis (OA) is a prevalent degenerative joint disease, which is associated with chronic and disabling pain. The adipocytokines, resistin and tumor necrosis factor-alpha (TNF-α), might play a role in OA pathogenesis and outcomes. PURPOSE: The aim of this study was, therefore, to assess the anti-inflammatory and analgesic effects of a garlic supplement on serum resistin and TNF-α concentrations and on pain severity in overweight or obese women with knee OA...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
S Azizi, A Farsinejad, R Kheirandish, H Fatemi
OBJECTIVE: Osteoarthritis (OA) is one of the most common degenerative diseases especially in the knee joint. The definitive method for the treatment of this disease is not known. In recent years, use of platelet-derived products has been considered as a new therapeutic approach because of its low cost, easy to use, and minimum side effects. Serum rich of growth factors (SRGF) is one of the biological compounds used to healing and regeneration. Its effects may improve in combination with antioxidants such as vitamin C...
August 25, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Kelsey H Collins, Behnam Sharif, Raylene A Reimer, Claudia Sanmartin, Walter Herzog, Rick Chin, Deborah A Marshall
Background: Osteoarthritis (OA) is a chronic degenerative joint disease. While it is well-established that obesity affects OA through increased axial loading on the joint cartilage, the indirect effect of obesity through metabolic processes among the body mass index (BMI)-defined non-obese population, i.e., BMI < 30 kg/m2 , is less known. Our goal was to evaluate the association of metabolic markers including body fat percentage (BF%), waist circumference, maximum weight gain during adulthood and serum creatinine with self-reported OA to establish if such measures offer additional information over BMI among the non-obese population between 40 and 65 years of age...
2018: BMC Obesity
Wenxing Yu, Peng Xu, Guiling Huang, Lin Liu
Knee osteoarthritis is the most common degenerative disease of the joints caused by articular cartilage injury, degradation of the joint edge and subchondral bone hyperplasia. Various treatments are used to alleviate the symptoms of patients with knee osteoarthritis, including analgesics and intra-articular injections. Platelet-rich plasma (PRP) is an autologous and multifunctional platelet concentrate of the blood, which stimulates the cartilage healing process and improves the damage caused by articular disease...
September 2018: Experimental and Therapeutic Medicine
Yung-Tsung Cheng, Cheng-Chi Tai, Willy Chou, Shih-Tsang Tang, Jiun-Hung Lin
The advance of modern medical technology has extended people's life and increased the average age of the society. Some chronic diseases are due to the aging of the population and knee joint aging is a common disease in the elderly. Common joint pathology contains degenerative arthritis, arthroncus of knees, and gouty arthritis. Knee joints are the largest and the most complicated joints in a human body as well as the joint bearing huge pressure. Wrong posture, overuse, or vigorous exercise often cause injuries to knee joints, and such injuries could easily result in joint pathology and patients falling and breaking bones due to pain and powerlessness...
August 2018: Review of Scientific Instruments
A W Lin, N Vapniarsky, D D Cissell, F J M Verstraete, C H Lin, D C Hatcher, B Arzi
This study aimed to characterize the histological, biomechanical and biochemical properties of the temporomandibular joint (TMJ) of the domestic dog in health and disease. In addition, we sought to identify structure-function relationships and to characterize TMJ degenerative lesions that may be found naturally in this species. TMJs (n = 20) from fresh cadaver heads (n = 10) of domestic dogs were examined macroscopically and microscopically and by cone-beam computed tomography. The TMJ discs were evaluated for their mechanical and biochemical properties...
May 2018: Journal of Comparative Pathology
Christopher M De Geer
Objective: The purpose of this paper was to review the literature regarding the mechanisms leading to degeneration in intervertebral disks and to discuss contributing mechanical and biological factors. Methods: The inclusion criteria for the literature review were research studies conducted in the last 3 decades with free full-text available in English. Review articles and articles pertaining to temporomandibular joints and joints of the body other than the intervertebral disk were excluded...
June 2018: Journal of Chiropractic Medicine
Sini Skarp, Olli-Pekka Kämäräinen, Gong-Hong Wei, Eveliina Jakkula, Ilkka Kiviranta, Heikki Kröger, Juha Auvinen, Petri Lehenkari, Leena Ala-Kokko, Minna Männikkö
INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease and one of the major causes of disability worldwide. It is a multifactorial disorder with a significant genetic component. The heritability of OA has been estimated to be 60% for hip OA and 39% for knee OA. Genetic factors behind OA are still largely unknown. Studying families with strong history of OA, facilitates examining the co-segregation of genetic variation and OA. The aim of this study was to identify new, rare genetic factors and novel candidate genes for OA...
2018: PloS One
Nina Vadiei, Tawny L Smith, Erica C Garcia-Pittman
Objective: To report a case of oral candidiasis that developed in a 70-year-old white female both upon initiation and rechallenge of extended-release bupropion therapy. Case Summary: A 70-year-old female with a past medical history of osteoarthritis, degenerative joint disease, and polycythemia vera developed oral candidiasis on 2 occasions following initiation of extended-release bupropion for the treatment of recurrent depression. During both instances, the reaction occurred with an increased dose of the medication, suggesting the adverse event may have been dose-related...
July 2018: The mental health clinician
Weikai Zhang, Peng Cheng, Weihua Hu, Weifeng Yin, Fengjing Guo, Anmin Chen, Hui Huang
PURPOSE: Osteoarthritis (OA) is a degenerative joint disease that leads to the destruction of joint function. The aim of this study is to investigate the effects of microRNA-340-5p (miR-340-5p) and its target gene, FMOD, on the proliferation and apoptosis of chondrocytes in mice with OA through the extracellular signal-regulated kinase (ERK) signaling pathway. MATERIALS: Twenty healthy C57BL/6J mice aged 15 months with a weight of 50 ± 2 g were selected...
August 24, 2018: Journal of Cellular Physiology
Jinsoo Song, In-Jeoung Baek, Churl-Hong Chun, Eun-Jung Jin
Osteoarthritis (OA) is the most common degenerative joint disease; however, its etiopathogenesis is not completely understood. Here we show a role for NUDT7 in OA pathogenesis. Knockdown of NUDT7 in normal human chondrocytes results in the disruption of lipid homeostasis. Moreover, Nudt7-/- mice display significant accumulation of lipids via peroxisomal dysfunction, upregulation of IL-1β expression, and stimulation of apoptotic death of chondrocytes. Our genome-wide analysis reveals that NUDT7 knockout affects the glycolytic pathway, and we identify Pgam1 as a significantly altered gene...
August 24, 2018: Nature Communications
Anna Osiecka-Iwan, Anna Hyc, Dorota M Radomska-Lesniewska, Adrian Rymarczyk, Piotr Skopinski
In physiological conditions chondrocytes are protected from contact with immunocompetent cells by the extracellular matrix, and transplanted fragments of allogeneic cartilage are not rejected. Cartilage produced by allogeneic chondrocytes, however, evokes the immune response of the recipient and is gradually destroyed. Immunisation by allogeneic chondrocytes is induced by the contact of their surface molecules with cells of the immune system. Chondrocytes constitutively express class I and, in some species, class II major histocompatibility complex (MHC) molecules...
2018: Central-European Journal of Immunology
Yangxue Zhao, Jiang Zhao, Xufeng Guo, Jiang She, Yongjun Liu
Osteoarthritis (OA), a common form of degenerative joint disease, is typified by inflammatory response and the loss of cartilage matrix. Long non-coding RNAs (lncRNAs) are emerging as a new player in gene regulation and exert critical roles in diverse physiologic and pathogenic processes including OA. The lncRNA plasmacytoma variant translocation 1 (PVT1) has been implicated in cancer, diabetes and septic acute kidney injury. Recent research confirmed the elevation of PVT1 in patients with OA. However, its role in the development of OA remains poorly elucidated...
August 20, 2018: Bioscience Reports
Xiaobin Li, Dengying Wu, Zhichao Hu, Jiangwei Xuan, Xiaoxia Ding, Gang Zheng, Zhenhua Feng, Wenfei Ni, Aimin Wu
BACKGROUND/AIMS: Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment closely linked to extracellular matrix (ECM) degradation. Ligustilide (LIG) is a major component of the herb Radix Angelicae Sinensis, with demonstrated anti-inflammatory effects. To confirm whether LIG has an equally inhibitory effect on inflammation in human osteoarthritis chondrocytes, we performed in vivo and in vitro experiments to validate the above conjectures and determine the relevant mechanisms...
2018: Cellular Physiology and Biochemistry
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