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Degenerative joint disease

Jianjun Wu, Min Zou, Ansong Ping, Zhouming Deng, Lin Cai
Osteoarthritis (OA) is a highly prevalent chronic and degenerative joint disease characterized by the continuous destruction of the articular cartilage. MicroRNAs (miRNAs) have been reported to be strongly involved in the pathogenesis of OA. The aim of this study was to explore whether miR-449a regulates the expression of growth differentiation factor5 (GDF5), which promotes chondrocyte extracellular matrix (ECM) degradation. We found that miR-449a expression was upregulated in OA cartilage compared to that in normal cartilage...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xiaojian Huang, Qiyong Pan, Zekai Mao, Pengcheng Wang, Rui Zhang, Xiaohu Ma, Jingyuan Chen, Hongbo You
Osteoarthritis (OA) is a common degenerative joint disease in older adults. A number of previous studies have demonstrated that natural flavonoids can serve as promising therapeutic drugs for OA. Kaempferol, a phytochemical ingredient mainly present in various fruits, has exhibited its prominent anti‑inflammatory and antioxidant effects in numerous diseases. However, whether Kaempferol ameliorates the deterioration of arthritis remains to be elucidated. The aim of the present study was to investigate the therapeutic role of Kaempferol on OA in rat chondrocytes...
July 16, 2018: Molecular Medicine Reports
Dengying Wu, ShanShan Jin, Zeng Lin, Rong Chen, Tianlong Pan, Xiaodiao Kang, Huasong Huang, Cong Lin, Jun Pan
BACKGROUND: Osteoarthritis (OA) is a common degenerative joint disease for which currently no anti-inflammatory therapy is available. Sauchinone (SAU), a key bioactive compound derived from Saururus chinensis, which has shown remarkable anti-inflammatory effects. METHODS: To evaluate the effect of SAU on OA progression, mouse chondrocytes were pretreated with SAU and subsequently stimulated with interleukin (IL)-1β. We found that SAU reduced the production of pro-inflammatory cytokines, such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and IL-6...
July 13, 2018: International Immunopharmacology
Clare Death, Graeme Coulson, Uwe Kierdorf, Horst Kierdorf, Richard Ploeg, Simon Firestone, Ian Dohoo, Jasmin Hufschmid
One of the manifestations of chronic fluoride toxicosis in mammals is skeletal fluorosis, which can include lesions of degenerative joint disease (DJD). Although DJD lesions have been less commonly studied than bone or dental lesions in relation to the pathology and epidemiology of fluoride toxicosis, there have been multiple independent studies in various species that have concluded that there appears to be an effect. The mechanisms by which fluoride affects the joints are not clear, but our data provide evidence that chronic excess dietary fluoride intake contributes to DJD...
July 12, 2018: Ecotoxicology and Environmental Safety
Ikuko Kashino, Mauro Serafini, Junko Ishihara, Tetsuya Mizoue, Ayaka Sunami, Koutatsu Maruyama, Norie Sawada, Manami Inoue, Akiko Nanri, Kayo Kurotani, Shamima Akter, Motoki Iwasaki, Shoichiro Tsugane
BACKGROUND: High dietary non-enzymatic antioxidant capacity (NEAC) has been inversely related to the incidence of degenerative diseases. However, few studies have investigated the validity and reproducibility of dietary NEAC estimated from a food frequency questionnaire (FFQ). We assessed the validity and reproducibility of FFQ-based dietary NEAC against a dietary record (DR). METHODS: Participants were 244 men and 253 women who completed a 28-day DR and FFQs. NEAC for each food item was estimated according to available databases of antioxidant capacity, as measured by ferric reducing-antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and total radical-trapping antioxidant parameter (TRAP)...
July 14, 2018: Journal of Epidemiology
Shravan Kumar Renapurkar
As knowledge of the complexity of myofascial pain and its interaction with temporomandibular joint disorders has increased, the use of surgical procedures to treat degenerative joint disease has decreased. The focus has moved from a "surgery-first" approach toward a more cautious one that involves nonsurgical treatment as the primary modality, then minimally invasive treatments, followed by open surgical modalities, when indicated. This article examines the current literature regarding the effectiveness of nonsurgical and surgical treatments for the management of degenerative joint disease...
August 2018: Oral and Maxillofacial Surgery Clinics of North America
J C Nickel, L R Iwasaki, Y M Gonzalez, L M Gallo, H Yao
Craniofacial secondary cartilages of the mandibular condyle and temporomandibular joint (TMJ) eminence grow in response to the local mechanical environment. The intervening TMJ disc distributes normal loads over the cartilage surfaces and provides lubrication. A better understanding of the mechanical environment and its effects on growth, development, and degeneration of the TMJ may improve treatments aimed at modifying jaw growth and preventing or reversing degenerative joint disease (DJD). This review highlights data recorded in human subjects and from computer modeling that elucidate the role of mechanics in TMJ ontogeny...
July 1, 2018: Journal of Dental Research
Seung Hoon Lee, Ji Ye Kwon, JooYeon Jhun, KyungAh Jung, Sung-Hwan Park, Chul Woo Yang, YongSin Cho, Seok Jung Kim, Mi-La Cho
Osteoarthritis (OA) is a chronic and degenerative disease that causes pain, cartilage deformation, and joint inflammation. Lactobacillus species have been used as dietary supplements to induce the production of antimicrobial and anti-inflammatory factors. The goal of this study was to determine whether Lactobacillus acidophilus ameliorates monosodium iodoacetate-induced OA. L. acidophilus showed anti-nociceptive properties and protected against cartilage destruction. It also downregulated the levels of proinflammatory cytokines and increased the levels of anti-inflammatory cytokines in the joints of OA rats...
July 9, 2018: Immunology Letters
Xin Wang, Yongning Li, Jun Gao, Tianyu Wang, Zhimin Li
RATIONALE: Charcot arthropathy, also known as Neuropathic arthropathy (NA), is an unusual chronic degenerative disease. To date, there exists a paucity of research on NA caused by syringomyelia. PATIENTS CONCERNS: A 52-year-old non-diabetic female presented with progressive swelling, pain and limited movement in her left shoulder joint combined with asthenia of her left upper extremity for three months. DIAGNOSES: Neuropathic arthropathy of the shoulder associated with the cervicothoracic syrinx and basilar impressions was diagnosed...
July 2018: Medicine (Baltimore)
Iris Ribitsch, Rupert L Mayer, Monika Egerbacher, Simone Gabner, Maciej M Kańduła, Julie Rosser, Eva Haltmayer, Ulrike Auer, Sinan Gültekin, Johann Huber, Andrea Bileck, David P Kreil, Christopher Gerner, Florien Jenner
Osteoarthritis (OA), a degenerative joint disease characterized by progressive cartilage degeneration, is one of the leading causes of disability worldwide owing to the limited regenerative capacity of adult articular cartilage. Currently, there are no disease-modifying pharmacological or surgical therapies for OA. Fetal mammals, in contrast to adults, are capable of regenerating injured cartilage in the first two trimesters of gestation. A deeper understanding of the properties intrinsic to the response of fetal tissue to injury would allow us to modulate the way in which adult tissue responds to injury...
July 6, 2018: Disease Models & Mechanisms
I V Baranova
BACKGROUND: In the recent years, the ever increasing tendency toward the growth in the prevalence of degenerative-dystrophic articular diseases has been observed especially among the young subjects and the middle-aged people. The enhanced economic burden of treating the patients with this condition on the public health care system frequently comes not only from chronic pathology of the joints but also from the development of concomitant disorders which dictates the necessity of the search for the new methods for the management of such patients...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Lucy Ngo, Lillian E Knothe, Melissa L Knothe Tate
The role of molecular size selectivity in the onset and progression of osteoarthritis (OA), a degenerative disease of the musculoskeletal system and the most common cause of disability in aging adults, is unknown. Here we delivered a mixture of Texas-red (70 kDa), and Rhodamine-green (10 kDa) tagged, dextrans of neutral charge in a single bolus via heart injection to middle aged (8-10 months) and aged (17-19 months) Dunkin-Hartley Guinea pigs, a natural model for OA. We quantified tracer transport in serial-sectioned, cryofixed block specimens after five minutes' circulation...
July 6, 2018: Scientific Reports
Arnold-Peter C Weiss, Avi D Goodman
The thumb basal joint is the second most common site of osteoarthritis in the hand, and osteoarthritis of this joint can contribute to painful movement and debilitating function. To achieve a high degree of prehensile and manipulative function, this highly mobile joint is constrained by both the saddle morphology of the trapezium and a stout complement of ligamentous constraints. The disease proceeds progressively with several wear patterns. Substantial new biomechanical and longitudinal clinical studies have changed some of the prevailing opinions on the process of serial degenerative changes...
June 27, 2018: Journal of the American Academy of Orthopaedic Surgeons
Elena Damia, Deborah Chicharro, Sergio Lopez, Belen Cuervo, Monica Rubio, Joaquin J Sopena, Jose Manuel Vilar, Jose Maria Carrillo
Osteoarthritis (OA) is a major cause of disability in elderly population around the world. More than one-third of people over 65 years old shows either clinical or radiological evidence of OA. There is no effective treatment for this degenerative disease, due to the limited capacity for spontaneous cartilage regeneration. Regarding the use of regenerative therapies, it has been reported that one option to restore degenerated cartilage are adipose-derived mesenchymal stem cells (ASCs). The purpose of this review is to describe and compare the efficacy of ASCs versus other therapies in OA...
June 30, 2018: International Journal of Molecular Sciences
Marcelo Freire Matos, Ivson Souza Catunda, Jane Luzia Matos, Belmiro Cavalcanti Vasconcelos, Jorge Alfonso Learreta
The etiology of degenerative processes of the temporomandibular joint (TMJ) remains unclear, as they could be the result of trauma, infection, or autoimmune disease. Improving the diagnosis of autoimmune disease, whether the TMJ is the primary site or secondarily affected by a systemic disease, is of fundamental importance in selecting treatment that will address the causes rather than just relieve the symptoms. The purposes of this article are to discuss autoimmunity as an etiologic factor in degenerative processes of the TMJ by presenting clinical cases and to highlight the importance of imaging and serologic examinations for diagnosis...
July 2018: General Dentistry
Shanti Kaimal, Mansur Ahmad, Wenjun Kang, Donald Nixdorf, Eric L Schiffman
The objective of this study was to determine the diagnostic accuracy of panoramic radiography and magnetic resonance imaging (MRI) for detection of signs of temporomandibular joint (TMJ) degenerative joint disease (DJD). Panoramic radiography and bilateral MRI and computed tomography (CT) of the TMJs were performed for 705 subjects. Three calibrated board-certified radiologists who were blinded to the clinical findings interpreted all images. The diagnoses of DJD established using the panoramic radiographs and MRIs were compared to the reference standard diagnoses derived from the CTs...
July 2018: General Dentistry
Luyao Wang, Haojie Shan, Bin Wang, Nan Wang, Zubin Zhou, Chenhao Pan, Feng Wang
BACKGROUND/AIMS: Osteoarthritis is the most common degenerative joint disease and causes major pain and disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes was associated with osteoarthritis. Puerarin has multiple effects including restoring mitochondrial function. In this study, the potential effects of puerarin on osteoarthritis and osteoarthritis associated mitochondrial dysfunctions were evaluated. METHODS: Osteoarthritis rats were treated with puerarin and the severity of osteoarthritis and cartilage damages was evaluated...
June 29, 2018: Pharmacology
Charlotte Gil, Hendy Abdoul, Raphaël Campagna, Henri Guerini, Estelle Ieong, Franck Chagny, Catherine Bedin, Alexandra Roren, Marie-Martine Lefèvre-Colau, Serge Poiraudeau, Antoine Feydy, François Rannou, Christelle Nguyen
INTRODUCTION: Recent studies have suggested that intra-articular injection of botulinum toxin A (BTA) may have analgesic effects in degenerative joint diseases. We aim to assess the efficacy of intra-articular injection of BTA associated with splinting in patients with trapeziometacarpal osteoarthritis (TMC OA). METHODS AND ANALYSIS: We will conduct a randomised double-blind controlled trial. Overall, 60 individuals with TMC OA fulfilling adapted 1990 American College of Rheumatology criteria for hand OA will be recruited in one tertiary care centre in France and randomised to receive splinting + a single ultrasound-guided injection in the TMC joint of 50 Allergan Units of BTA resuspended in 1 mL saline or splinting +1 mL saline...
June 30, 2018: BMJ Open
Marloes van Onna, Betül Öztürk, Mirian Starmans, Ralph Peeters, Annelies Boonen
To explore in elderly patients with rheumatoid arthritis (RA) and comorbidity (1) in which order and why patients prioritize their morbidities with regard to functioning and health, (2) their beliefs about common (age-related) musculoskeletal complaints, and (3) experiences about the influence of comorbidity on medication treatment of RA. Patients between 50 and 85 years with RA and ≥ 1 comorbidity or lifestyle risk factor were invited for a semi-structured interview. Two readers coded the transcripts of the interviews, by using NVivo11 software...
June 9, 2018: Clinical Rheumatology
Fu-Hui Dong
The miminally-invasive techniques of traditional Chinese medicine(TCM) uses different types of acupuncture needles to treat diseased locations with special techniques. These techniques include different methods of insertion and closed incision (press cutting, sliding cutting, scrape cutting, etc.). This needling technique is based on the traditional Chinese medicine theories of Pi Bu (cutaneous), Jing Jin (sinew), Jing Luo (meridian), Wu Ti (five body structure components) and Zang Fu (organ system). Commonly used needles include: needle Dao , needle with edge, Pi needle, Shui needle, Ren needle, Gou needle, Chang Yuan needle, Bo needle and so on...
June 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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