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Degenerative joint disease

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https://www.readbyqxmd.com/read/28087283/benefits-of-using-the-ultrasonic-bonescalpel%C3%A2-in-temporomandibular-joint-reconstruction
#1
Rebeka Silva, Rishi Gupta, Gianluca Tartaglia, Stephen Connelly
PURPOSE: The main objective of this retrospective study is to analyze and report on our operative experiences and outcomes using the ultrasonic BoneScalpel™ (BoneScalpel) versus a conventional reciprocating saw (RecipSaw) for the purpose of completing the osteotomies in total temporomandibular joint reconstruction (TJR) surgery. MATERIALS AND METHODS: 23 consecutive patients presented with a diagnosis of either degenerative joint disease (n = 23), a failing autogenous TJR (n = 1), heterotrophic bone formation (n = 1) or a subcondylar fracture (n = 1) for a total of 26 joints that received a TJR...
December 19, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28079507/do-micrornas-have-a-key-epigenetic-role-in-osteoarthritis-and-in-mechanotransduction
#2
REVIEW
Anna De Palma, Sara Cheleschi, Nicola Antonio Pascarelli, Sara Tenti, Mauro Galeazzi, Antonella Fioravanti
Osteoarthritis (OA) is the most common degenerative disease affecting joint tissues. The pathogenesis of OA is complex and poorly understood, as well as the multiple factors contributing to its development and progression. Accumulating evidence has suggested that microRNAs (miRNAs) play an important role as regulators of cartilage biology and in the pathogenesis of OA. It has been demonstrated that mechanical loading, important for the regulation of cartilage metabolism, affects miRNAs expression. Furthermore, miRNAs present in human plasma and in synovial fluid could represent promising biological markers for OA...
January 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28078641/staple-line-leak-after-primary-sleeve-gastrectomy-risk-factors-and-mid-term-results-do-patients-still-benefit-from-the-weight-loss-procedure
#3
Frank Benedix, Oliver Poranzke, Daniele Adolf, Stephanie Wolff, Hans Lippert, Jörg Arend, Thomas Manger, Christine Stroh
BACKGROUND: Staple line leak after laparoscopic sleeve gastrectomy (LSG) still represents the most feared complication. The purpose of this study was to investigate whether there are factors that increase the risk for a leakage. Furthermore, we aimed to analyze the impact of a leak on weight change and resolution of comorbidities. METHODS: Since 2005, data from obese patients that undergo bariatric procedures in Germany are prospectively registered. For the current analysis, all adult subjects that had undergone primary LSG from 2005 to 2014 were considered...
January 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28070636/extracellular-matrix-loss-in-chondrocytes-after-exposure-to-interleukin-1%C3%AE-in-nadph-oxidase-dependent-manner
#4
Sakie Funato, Rika Yasuhara, Kentaro Yoshimura, Yoichi Miyamoto, Kotaro Kaneko, Tetsuo Suzawa, Daichi Chikazu, Kenji Mishima, Kazuyoshi Baba, Ryutaro Kamijo
Osteoarthritis is a degenerative joint disease caused by excessive death of chondrocytes and loss of the extracellular matrix (ECM) in articular cartilage. We previously reported that reactive oxygen species (ROS) generated by the NADPH oxidase (NOX) isoform NOX-2 are involved in chondrocyte death induced by interleukin-1β (IL-1β). In this study, we investigate the role of NOX-2 in the production and degradation of ECM by chondrocytes. Although IL-1β lowered the mRNA expression of type II collagen (Col2a1) and aggrecan (Acan) in mouse chondrocyte-like ATDC5 cells, RNA silencing of Nox2 did not change the mRNA expression of these major components of the ECM of cartilage...
January 9, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28070627/-tendinopathy-in-rheumatic-diseases
#5
M Henniger, S Rehart
Involvement of tendons and tendon sheaths is frequently found in the most common inflammatory systemic diseases, rheumatoid arthritis and spondyloarthritis. In rheumatoid arthritis tendon manifestations occur as tenosynovitis, with swelling and pain of the tendons mainly on the hands and feet. In spondyloarthritis the involvement of tendons presents as enthesitis with pain and swelling directly at the attachment points of tendons to the bony structures and more commonly in the lower extremities. Pathological alterations of tendons can be normally visualized by sonography and only sometimes with magnetic resonance imaging (MRI) or scintigraphy...
January 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28068790/temporomandibular-disorders-old-ideas-and-new-concepts
#6
Thomas List, Rigmor Højland Jensen
Background Temporomandibular disorders (TMD) is an umbrella term for pain and dysfunction involving the masticatory muscles and the temporomandibular joints (TMJs). TMD is the most common orofacial pain condition. Its prominent features include regional pain in the face and preauricular area, limitations in jaw movement, and noise from the TMJs during jaw movements. TMD affects up to 15% of adults and 7% of adolescents. Chronic pain is the overwhelming reason that patients with TMD seek treatment. TMD can associate with impaired general health, depression, and other psychological disabilities, and may affect the quality of life of the patient...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28066740/microinstability-of-the-hip-a-previously-unrecognized-pathology
#7
Ioanna Bolia, Jorge Chahla, Renato Locks, Karen Briggs, Marc J Philippon
BACKGROUND: Hip microinstability is an established diagnosis; however, its occurrence is still debated by many physicians. Diagnosis of hip microinstability is often challenging, due to a lack of specific signs or symptoms, and patients may remain undiagnosed for long periods. This may lead to early manifestation of degenerative joint disease. Consequently, careful patient and family history must be obtained and diagnostic imaging should follow. After a thorough clinical evaluation of the patient with suspected hip microinstability, the physician should focus on how to improve symptoms and functionality in daily and sports activities...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28064032/tmj-energy-densities-in-healthy-men-and-women
#8
L R Iwasaki, Y M Gonzalez, Y Liu, H Liu, M Markova, L M Gallo, J C Nickel
OBJECTIVE: Cartilage fatigue, due to mechanical work, may account for the early development of degenerative joint disease in the temporomandibular joint (TMJ), and why women are 3-times more likely to be afflicted. This study tested for gender differences in mechanical energy densities in women and men with healthy TMJs. DESIGN: Eighteen women and eighteen men gave informed consent. Research diagnostic criteria including imaging were used to ensure that subjects' TMJs were normal, without disc displacement or signs of degenerative joint disease...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28063477/evaluation-of-serum-cytokines-in-cats-with-and-without-degenerative-joint-disease-and-associated-pain
#9
Margaret E Gruen, Kristen M Messenger, Andrea E Thomson, Emily H Griffith, Lauren A Aldrich, Shelly Vaden, B Duncan X Lascelles
Degenerative joint disease is common in cats, with signs of pain frequently found on orthopedic examination and radiographs often showing evidence of disease. However, understanding of the pathophysiology of degenerative joint disease and associated pain remains limited. Several cytokines have been identified as having a role in pain in humans, but this has not been investigated in cats. The present study was performed to use a multiplex platform to evaluate the concentration of 19 cytokines and chemokines in serum samples obtained from cats with and without degenerative joint disease and associated pain...
January 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28049396/oxidative-stress-and-antioxidant-potential-of-one-hundred-medicinal-plants
#10
Waseem Hassan, Hamsa Noreen, Shakila Rehman, Shehnaz Gul, Mohammad Amjad Kamal, Jean Paul Kamdem, Bakht Zaman, Joao B T da Rocha
Reactive species are produced in biological system because of redox reactions. The imbalance in pro-oxidant and antioxidant homeostasis leads to the production of toxic reactive oxygen and nitrogen species like hydrogen peroxide, organic peroxides, hydroxyl radicals, superoxide anion and nitric oxide. Inactivation of metabolic enzymes, oxidation of biomolecules and cellular damage are some of the prominent characteristics of reactive species. Similarly, oxidative stress has been associated with more than one hundred (100) pathologies such as atherosclerosis, diabetes, cardiovascular diseases, pancreatic and liver diseases, joint disorders, cardiac fibrosis, acute respiratory distress syndrome, neurological diseases (amyotrophic lateral sclerosis, Huntington's disorder, Parkinson's disease and Alzheimer's disease), ageing and cancer etc...
January 2, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28049007/cellular-aging-towards-osteoarthritis
#11
REVIEW
Yu-Sheng Li, Wen-Feng Xiao, Wei Luo
Osteoarthritis (OA) is a common form of degenerative joint disease. Aging process is supposed to be a leading predictor for developing OA. In this review, we have discussed the potential roles of aging in OA, a better understanding of which might delay or stop the development and progression of OA. Different cellular signaling mechanisms are involved process of aging that induces age-related changes in chondrocytes. These changes influence the expression of catabolic factors resulting in increased production of matrix metalloproteinases and cytokines, reduced levels of collagen type II and aggrecan synthesis, and increased production of reactive oxygen species (ROS)...
December 31, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28039964/degenerative-joint-diseases-and-neuroinflammation
#12
REVIEW
Mariella Fusco, Stephen D Skaper, Stefano Coaccioli, Antonella Paladini, Giustino Varrassi
Rheumatic and joint diseases, as exemplified by osteoarthritis and rheumatoid arthritis, are among the most widespread painful and disabling pathologies across the globe. Given the continuing rise in life expectancy, their prevalence is destined to grow. Osteoarthritis, a degenerative joint disease, is, in particular, on its way to becoming the fourth leading cause of disability worldwide by 2020, with the rising incidence of obesity in addition to age being important factors. It is estimated that 25% of osteoarthritic individuals are unable to perform daily activities...
December 31, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28031953/ultrasound-with-mineral-water-or-aqua-gel-to-reduce-pain-and-improve-the-womac-of-knee-osteoarthritis
#13
Sahar Ahmed Abdalbary
AIMS: Osteoarthritis is the most degenerative joint disease. The aim was to investigate the effects of ultrasound using mineral water or aqua sonic gel on severity of knee pain, measured by the visual analog scale and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). MATERIALS AND METHODS: Thirty women with bilateral osteoarthritis of the knee were assigned to two groups: ultrasound with mineral water (group 1, n = 15) or with aqua sonic gel (group 2, n = 15)...
March 2016: Future Science OA
https://www.readbyqxmd.com/read/28010837/raptor-acupuncture-for-treating-chronic-degenerative-joint-disease
#14
Keum Hwa Choi, Gail Buhl, Julia Ponder
A permanently captive 21-year-old male bald eagle was diagnosed with chronic degenerative joint disease in the right stifle with severe lameness (Grade 5) based on radiography. Clinical signs included decreased movement, vocalization, non weight-bearing on the affected limb, inappetence, depression, and pododermatitis on the left foot (bumblefoot, Grade 3). The eagle was treated with anti-inflammatory or analgesic drugs including carprofen and celecoxib. As there was no observed clinical improvement with any of the treatments, acupuncture treatment was provided...
December 2016: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28005935/a-biomechanical-stability-study-of-extraforaminal-lumbar-interbody-fusion-on-the-cadaveric-lumbar-spine-specimens
#15
Song Guo, Cheng Zeng, Meijun Yan, Yingchao Han, Dongdong Xia, Guixin Sun, Lijun Li, Mingjie Yang, Jun Tan
BACKGROUND: Transforaminal lumbar interbody fusion (TLIF) is an effective surgery for lumbar degenerative disease. However, this fusion technique requires resection of inferior facet joint to provide access for superior facet joint resection, which results in reduced lumbar spinal stability and unnecessary trauma. We have previously developed extraforaminal lumbar interbody fusion (ELIF) that can avoid back muscle injury with direct nerve root decompression. This study aims to show that ELIF enhances lumbar spinal stability in comparison to TLIF by comparing lumbar spinal stability of L4-L5 range of motion (ROM) on 12 cadaveric spine specimens after performing TLIF or ELIF...
2016: PloS One
https://www.readbyqxmd.com/read/28003166/analysis-of-the-fusion-and-graft-resorption-rates-as-measured-by-ct-1-year-after-posterior-cervical-fusion-using-a-cervical-pedicle-screw
#16
Jae Koo Lee, Sang Ku Jung, Young-Seok Lee, Sang Ryong Jeon, Sung Woo Roh, Seung Chul Rhim, Jin Hoon Park
BACKGROUND: We previously showed that cervical pedicle screw placement (CPS) is safe even with the freehand technique. The posterolateral fusion rate 1 year after CPS, as measured by computed tomography (CT), is reported here. The graft resorption rates when different graft materials were used were also analyzed. METHODS: Between 2012- 2015, 93 patients underwent posterior cervical fusion surgery with the CPS from C2 to C7. Of these, 56 patients consented to CT scans immediately and 1 year after surgery...
December 18, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28002903/the-cytokinome-in-osteoarthritis-a-new-paradigm-in-diagnosis-and-prognosis-of-cartilage-disease
#17
R Papalia, G Vadalà, G Torre, M Perna, L Saccone, F Cannata, V Denaro
At present, diagnosis and progression monitoring of osteoarthritis (OA) is made through radiological and clinical assessment. Several studies investigated the role of synovial fluid analysis, to find out whether joint disease could be characterized by the pattern of cytokines, which acts during the pathogenic process or in specific stages of it. Online PubMed-Medline search was performed in order to retrieve evidence concerning synovial fluid analysis of cytokines involved in OA degenerative process. Concerning pro-inflammatory cytokines, it has been shown that interleukin (IL)-6, TNF-α and IL-17 are mainly over-expressed in the synovial fluid of OA joints, as well as anti-inflammatory cytokine IL-10...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27993154/efficacy-and-safety-of-adult-human-bone-marrow-derived-cultured-pooled-allogeneic-mesenchymal-stromal-cells-stempeucel%C3%A2-preclinical-and-clinical-trial-in-osteoarthritis-of-the-knee-joint
#18
Pawan Kumar Gupta, Anoop Chullikana, Mathiyazhagan Rengasamy, Naresh Shetty, Vivek Pandey, Vikas Agarwal, Shrikant Yeshwant Wagh, Prasanth Kulapurathu Vellotare, Devi Damodaran, Pachaiyappan Viswanathan, Charan Thej, Sudha Balasubramanian, Anish Sen Majumdar
BACKGROUND: Osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the joints. Currently, cell-based therapy is being explored to address the repair of damaged articular cartilage in the knee joint. METHODS: The in vitro differentiation potential of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®) was determined by differentiating the cells toward the chondrogenic lineage and quantifying sulfated glycosaminoglycan (sGAG)...
December 20, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27980494/in-vivo-osteoinduction-evaluating-2-beta-coxatene-as-an-immunoinductive-compound-and-novel-ingredient-for-joint-support
#19
Katherine Spinks, James J Scaffidi
CONTEXT: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage. Many treatments lack the ability to stimulate the growth of native cartilage tissue while they simultaneously increase joint comfort. For the past few decades, dietary supplements have been investigated for the ability to both address joint inflammation and stimulate cartilage tissue. OBJECTIVES: The present study intended to examine the supplement's in vivo osteoinductive capabilities and clinical efficacy for overall joint health...
October 2016: Integrative Medicine
https://www.readbyqxmd.com/read/27965138/the-str-ort-mouse-model-of-spontaneous-osteoarthritis-an-update
#20
REVIEW
K A Staines, B Poulet, D N Wentworth, A A Pitsillides
Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease...
December 11, 2016: Osteoarthritis and Cartilage
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