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Degenerative joint disease

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https://www.readbyqxmd.com/read/27902701/heads-shoulders-elbows-knees-and-toes-modular-gdf5-enhancers-control-different-joints-in-the-vertebrate-skeleton
#1
Hao Chen, Terence D Capellini, Michael Schoor, Doug P Mortlock, A Hari Reddi, David M Kingsley
Synovial joints are crucial for support and locomotion in vertebrates, and are the frequent site of serious skeletal defects and degenerative diseases in humans. Growth and differentiation factor 5 (Gdf5) is one of the earliest markers of joint formation, is required for normal joint development in both mice and humans, and has been genetically linked to risk of common osteoarthritis in Eurasian populations. Here, we systematically survey the mouse Gdf5 gene for regulatory elements controlling expression in synovial joints...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27900293/combined-use-of-platelet-rich-plasma-micro-fat-in-sport-and-race-horses-with-degenerative-joint-disease-preliminary-clinical-study-in-eight-horses
#2
Fabrizio Bembo, Julia Eraud, Cecile Philandrianos, Baptiste Bertrand, Alain Silvestre, Julie Veran, Florence Sabatier, Guy Magalon, Jeremy Magalon
BACKGROUND: To assess the safety and potential efficacy of a standardized technique consisting of intra-articular injection of 10 cc of a homogeneous mixed product using autologous micro-fat and platelet rich plasma (PRP) (ratio 1:1) in the carpus or the fetlock joint of sport horses presenting degenerative joint disease (DJD). METHODS: Eight sport horses with DJD confirmed by radiography and ultrasonography and causing lameness and the impossibility to compete were treated...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27891035/intradiscal-and-intra-articular-facet-infiltrations-with-plasma-rich-in-growth-factors-reduce-pain-in-patients-with-chronic-low-back-pain
#3
Fernando Kirchner, Eduardo Anitua
CONTEXT: Low back pain (LBP) is a complex and disabling condition, and its treatment becomes a challenge. AIMS: The aim of our study was to assess the clinical outcome of plasma rich in growth factors (PRGF-Endoret) infiltrations (one intradiscal, one intra-articular facet, and one transforaminal epidural injection) under fluoroscopic guidance-control in patients with chronic LBP. PRGF-Endoret which has been shown to be an efficient treatment to reduce joint pain...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27890247/reproducibility-of-x-rays-and-ct-arthrography-in-slac-snac-scac-wrists
#4
R Belhaouane, N Lebeau, C Maes-Clavier, C Hustin, E Krief, B Bonnaire, M Warin, V Rotari, E David
The purpose of this study was to assess the inter-observer and intra-observer reproducibility of the interpretation of CT arthrography and plain X-rays for scapholunate advanced collapse (SLAC), scaphoid non-union advanced collapse (SNAC) and scaphoid chondrocalcinosis advanced collapse (SCAC) wrist conditions, as well as the clinical relevance of these imaging modalities. The CT and X-rays images were reviewed twice in a blinded and randomized manner by two experienced orthopedic surgeons specialized in hand surgery, two orthopedic surgery residents and two experienced radiologists specialized in bone and joint imaging...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27876656/postural-sway-balance-confidence-and-fear-of-falling-in-women-with-knee-osteoarthritis-in-comparison-to-matched-controls
#5
Marcelo Taglietti, Laís Faganello Dela Bela, Josilainne Marcelino Dias, Alexandre Roberto Marcondes Pelegrinelli, Jéssyca Fernandes Nogueira, João Pedro Batista Júnior, Rodrigo Gustavo da Silva Carvalho, Joseph Gerard McVeigh, Ligia Maria Facci, Felipe Arruda Moura, Jefferson Rosa Cardoso
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the knee joints. Individuals over 65 years with knee OA have a greater risk of falls. However, there has be limited examination of the parameters of postural sway (increased time, speed and postural sway area (center of pressure area (CoP)), and OA of the knee. OBJECTIVES: Primary: to determine whether the CoP variables discriminate between patients with knee OA and matched healthy volunteers, and to correlate the CoP variables with the Activities-Specific Balance Confidence Scale (ABC) and Falls Self-Efficacy Scale (FES); Secondary: to compare the CoP of the older women with OA with a control group in bipedal support condition with eyes opened and closed...
November 19, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27876332/long-term-results-after-sleeve-gastrectomy-a-systematic-review
#6
REVIEW
Žygimantas Juodeikis, Gintautas Brimas
Sleeve gastrectomy (SG) has become one of the most commonly used bariatric procedures worldwide. However, data regarding long-term results remain insufficient. The aim of this study was to review the long-term results after SG. We conducted a comprehensive literature search of Medline and the Cochrane Library for articles published until May 2016 on the long-term results (>5 yr) after SG. Studies representing outcomes of SG were included if they reported≥5-year results that contained at least one outcome of interest-weight loss, co-morbidities, long-term complications, or quality of life-and SG was performed as a primary procedure...
October 17, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27872981/dual-mobility-arthroplasty-failure-a-rationale-review-of-causes-and-technical-considerations-for-revision
#7
Philippe Hernigou, Arnaud Dubory, Damien Potage, François Roubineau, Charles Henri Flouzat Lachaniette
PURPOSE: Dual-mobility arthroplasty is an alternative to conventional total hip arthroplasty (THA) in appropriately selected, active adults with degenerative, necrotic or post-traumatic hip disease or with revision hip arthroplasty. Numerous papers have been published with results of dual-mobility arthroplasty, but there have been no comprehensive literature reviews that summarise the most recent findings and help the orthopaedic surgeon facing different scenarios in which revision of one or both components of a dual-mobility arthroplasty is indicated...
November 21, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27871411/injectable-recombinant-human-platelet-derived-growth-factor-in-collagen-carrier-for-hindfoot-fusion
#8
REVIEW
Andrew Dodd, Timothy R Daniels
Arthrodesis of the hindfoot is a common procedure for degenerative joint disease and/or severe deformity. Nonunion is a common complication from this procedure, causing an increased burden to the patient and health care system, often resulting in the need for revision surgery. Recombinant human platelet-derived growth factor (rhPDGF) has been shown to be a safe and effective tool to enhance arthrodesis rates in hindfoot surgery while avoiding the potential morbidity of bone grafting. This article provides a review of the role of rhPDGF in hindfoot fusions, and the surgical technique for performing an rhPDGF enhanced double-arthrodesis through a medial approach...
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27870898/functional-tissue-analysis-reveals-successful-cryopreservation-of-human-osteoarthritic-synovium
#9
Mathijs G A Broeren, Marieke de Vries, Miranda B Bennink, Peter L E M van Lent, Peter M van der Kraan, Marije I Koenders, Rogier M Thurlings, Fons A J van de Loo
Osteoarthritis (OA) is a degenerative joint disease affecting cartilage and is the most common form of arthritis worldwide. One third of OA patients have severe synovitis and less than 10% have no evidence of synovitis. Moreover, synovitis is predictive for more severe disease progression. This offers a target for therapy but more research on the pathophysiological processes in the synovial tissue of these patients is needed. Functional studies performed with synovial tissue will be more approachable when this material, that becomes available by joint replacement surgery, can be stored for later use...
2016: PloS One
https://www.readbyqxmd.com/read/27870580/clinical-characterization-of-patients-with-autosomal-dominant-short-stature-due-to-aggrecan-mutations
#10
Alexandra Gkourogianni, Melissa Andrew, Leah Tyzinski, Melissa Crocker, Jessica Douglas, Nancy Dunbar, Jan Fairchild, Mariana F A Funari, Karen E Heath, Alexander A L Jorge, Tracey Kurtzman, Stephen LaFranchi, Seema Lalani, Jan Lebl, Yuezhen Lin, Evan Los, Dorothee Newbern, Catherine Nowak, Micah Olson, Jadranka Popovic, Štěpánka Průhová, Lenka Elblova, Jose Bernardo Quintos, Emma Segerlund, Lucia Sentchordi, Marwan Shinawi, Eva-Lena Stattin, Jonathan Swartz, González-Del Angel Ariadna, Díaz-Cuéllar Sinhué, Hidekazu Hosono, Pedro A Sanchez-Lara, Vivian Hwa, Jeffrey Baron, Ola Nilsson, Andrew Dauber
CONTEXT: Heterozygous mutations in the Aggrecan gene (ACAN) cause autosomal dominant short stature with bone age (BA) acceleration, premature growth cessation and minor skeletal abnormalities. OBJECTIVE: Characterize the phenotypic spectrum, associated conditions and response to growth-promoting therapies. DESIGN: Retrospective international cohort study. PATIENTS: Information from 103 individuals (57 female, 46 male) from 20 families with confirmed heterozygous ACAN mutations were included...
November 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27867080/biomechanical-advantages-of-robot-assisted-pedicle-screw-fixation-in-posterior-lumbar-interbody-fusion-compared-to-free-hand-technique-in-a-prospective-randomized-controlled-trial-perspective-for-patient-specific-finite-element-analysis
#11
Ho-Joong Kim, Kyoung-Tak Kang, Sung-Cheol Park, Bong-Soon Chang, Choon-Ki Lee, Jin S Yeom, Lawrence G Lenke
BACKGROUND CONTEXT: There have been conflicting results regarding the surgical outcome of lumbar fusion surgery using two different techniques between robot-assisted pedicle screw fixation and conventional free-hand technique. In addition, there have been no studies about biomechanical issues between the both techniques. PURPOSE: To investigate biomechanical properties in terms of stress at adjacent segments using robot-assisted pedicle screw insertion technique (robot-assisted minimally invasive posterior lumbar interbody fusion, Rom-PLIF) and free-hand technique (conventional, free-hand, open approach, posterior lumbar interbody fusion, Cop-PLIF) for instrumented lumbar fusion surgery...
November 17, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27863553/a-comparison-of-serum-and-plasma-cytokine-values-using-a-multiplexed-assay-in-cats
#12
Margaret E Gruen, Kristen M Messenger, Andrea E Thomson, Emily H Griffith, Hayley Paradise, Shelly Vaden, B D X Lascelles
BACKGROUND: Degenerative joint disease (DJD) is highly prevalent in cats, and pain contributes to morbidity. In humans, alterations of cytokine concentrations have been associated with joint deterioration and pain. Similar changes have not been investigated in cats. Cytokine concentrations can be measured using multiplex technology with small samples of serum or plasma, however, serum and plasma are not interchangeable for most bioassays. Correlations for cytokine concentrations between serum and plasma have not been evaluated in cats...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27856966/longitudinal-stability-of-common-tmj-structural-disorders
#13
E L Schiffman, M Ahmad, L Hollender, K Kartha, R Ohrbach, E L Truelove, L Zhang, J S Hodges, E Sommers, G C Anderson, Y M Gonzalez, X Guo, J O Look
The longitudinal course of temporomandibular joint (TMJ) disc displacement (DD) and degenerative joint disease (DJD) has never been conclusively described with magnetic resonance imaging and computed tomography, respectively. This 8-y observational study's objective was to assess the longitudinal stability of DD and DJD among 401 subjects. The Validation Project provided baseline measures; follow-up was performed in the TMJ Impact Project. With magnetic resonance imaging, 2 radiologists rendered a consensus diagnosis of normal/indeterminate, DD with reduction, or DD without reduction...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27855045/-four-corner-fusion-in-patients-with-wrist-arthritis
#14
María Francisca Vázquez-Alonso, Alberto Viñas-Silva
Scapholunate advance collapse (SLAC) and Scaphoid nonunion advance collapse (SNAC), are the two most common patterns of postraumatic wrist arthritis. SLAC wrist develops after attenuation, either traumatically or atraumatically, of the scapholunate ligament. Atraumatic causes of SLAC wrist include calcium pyrophosphate dehydrate deposition disease, reumathoid arthritis, neuropathic diseases, and b2-microglobulin asociated amyloid deposition diseases. On the other hand, SNAC wrist develops following a scahpoid fracture that has progressed to a nonunion...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27842937/effectiveness-of-nerve-gliding-exercises-on-carpal-tunnel-syndrome-a-systematic-review
#15
Ruth Ballestero-Pérez, Gustavo Plaza-Manzano, Alicia Urraca-Gesto, Flor Romo-Romo, María de Los Ángeles Atín-Arratibel, Daniel Pecos-Martín, Tomás Gallego-Izquierdo, Natalia Romero-Franco
OBJECTIVE: The objective of this study was to review the literature regarding the effectiveness of neural gliding exercises for the management of carpal tunnel syndrome (CTS). METHODS: A computer-based search was completed through May 2014 in PubMed, Physiotherapy Evidence Database (PEDro), Web of Knowledge, Cochrane Plus, and CINAHL. The following key words were included: nerve tissue, gliding, exercises, carpal tunnel syndrome, neural mobilization, and neurodynamic mobilization...
November 11, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27836674/chondroprotective-activity-of-n-acetyl-phenylalanine-glucosamine-derivative-on-knee-joint-structure-and-inflammation-in-a-murine-model-of-osteoarthritis
#16
F Veronesi, G Giavaresi, M Maglio, A Scotto d'Abusco, L Politi, R Scandurra, E Olivotto, B Grigolo, R M Borzì, M Fini
OBJECTIVE: Osteoarthritis (OA), the most common chronic degenerative joint disease, is characterized by joint structure changes and inflammation, both mediated by the IκB kinase (IKK) signalosome complex. The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKα kinase activity, has been observed in vitro. The present study aims to further clarify the effect of NAPA in counteracting OA progression, in an in vivo mouse model after destabilization of the medial meniscus (DMM)...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27833961/predictive-model-of-synovial-membrane-degradation-using-semi-automated-morphometry-and-artificial-neural-networks
#17
Otilia Constantina Rogoveanu, Diana Kamal, Magdalena Rodica Trăistaru, Costin Teodor Streba
Gonarthrosis is a degenerative disease that affects mainly older people, but whose incidence has increased significantly in the last decade in population under the age of 65. The main objective of this study was developing a predictive model of synovial membrane degradation in relation to local nerve structures in patients with knee osteoarthritis, based on advanced morphometry and artificial neural networks (ANNs). We present here a pilot test of the method, describing preliminary findings in analyzing a pre-set number of images...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27829936/ultrasound-guided-arthroscopic-management-of-hallux-rigidus
#18
Łukasz M Paczesny, Jacek Kruczyński
INTRODUCTION: The use of metatarso-phalangeal joint arthroscopy in the treatment of osteochondritis dissecans was first described in 1988. The technique produces good results. However, it can be difficult to enter a joint when it is deformed by degenerative disease. Sonography is a modern visualisation modality which can be used in orthopaedic surgery. AIM: To describe a method of intraoperative sonographic navigation during first metatarso-phalangeal joint arthroscopy...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27821378/prevalence-of-humeral-head-osteochondrosis-in-the-greater-swiss-mountain-dog-and-the-border-collie-in-switzerland
#19
S Ohlerth, S Senn, U Geissbühler, P Kircher, M Flückiger
Osteochondrosis (OC) is common in large-breed dogs. According to the breeding guidelines of the Swiss kennel clubs, the shoulder joints are included in the radiographic screening for joint diseases in the Greater Swiss Mountain dog (GSMD) and the Border Collie (BC) since 1993 and 2003, respectively. The aim of this study was to estimate the overall prevalence of humeral head OC in these 2 breeds in Switzerland based on the data of the Swiss National Dysplasia Committees. All radiographs were re-evaluated to assess single radiographic changes...
November 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27821120/pro-inflammatory-cytokines-and-structural-biomarkers-are-effective-to-categorize-osteoarthritis-phenotype-and-progression-in-standardbred-racehorses-over-five-years-of-racing-career
#20
Andrea Bertuglia, Eleonora Pagliara, Elena Grego, Alessandro Ricci, Nika Brkljaca-Bottegaro
BACKGROUND: Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardbred racehorses developing traumatic osteoarthritis of the fetlock joint during the first year of their career were enrolled in our study. Age-matched controls were contemporarily included. Biomarker levels of equine osteoarthritis were measured in serum and synovial fluid (SF) at baseline, and repeated yearly over the next 4 years of training (from T1 to T4)...
November 8, 2016: BMC Veterinary Research
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