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https://www.readbyqxmd.com/read/28060775/customized-portable-neutron-activation-analysis-system-to-quantify-manganese-mn-in-bone-in-vivo
#1
Yingzi Liu, Farshad Mostafaei, Daniel Sowers, Ming-Jung Hsieh, Wei Zheng, Linda Nie
In the US alone, millions of workers, including over 300,000 welders, are at high risk of occupational manganese (Mn) exposure. Those who have been chronically exposed to excessive amount of Mn can develop severe neurological disorders similar, but not identical, to the idiopathic Parkinson's disease. One challenge to identify the health effects of Mn exposure is to find a reliable biomarker for exposure assessment, especially for long-term cumulative exposure. Mn's long biological half-life as well as its relatively high concentration in bone makes bone Mn (BnMn) a potentially valuable biomarker for Mn exposure...
January 6, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28049252/neurological-complications-resulting-from-non-oral-occupational-methanol-poisoning
#2
Ji Hyun Choi, Seung Keun Lee, Young Eun Gil, Jia Ryu, Kyunghee Jung-Choi, Hyunjoo Kim, Jun Young Choi, Sun Ah Park, Hyang Woon Lee, Ji Young Yun
Methanol poisoning results in neurological complications including visual disturbances, bilateral putaminal hemorrhagic necrosis, parkinsonism, cerebral edema, coma, or seizures. Almost all reported cases of methanol poisoning are caused by oral ingestion of methanol. However, recently there was an outbreak of methanol poisoning via non-oral exposure that resulted in severe neurological complications to a few workers at industrial sites in Korea. We present 3 patients who had severe neurological complications resulting from non-oral occupational methanol poisoning...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28041918/prediction-of-functional-outcome-in-young-patients-with-a-recent-onset-psychiatric-disorder-beyond-the-traditional-diagnostic-classification-system
#3
Amedeo Minichino, Marta Francesconi, Ricardo E Carrión, Arturo Bevilacqua, Maurizio Parisi, Santo Rullo, Agata Ando', Massimo Biondi, Roberto Delle Chiaie, Kristin Cadenhead
A critical research goal is to identify modifiable risk factors leading to functional disabilities in young psychiatric patients. The authors developed a multidimensional trans-diagnostic predictive model of functional outcome in patients with the recent-onset of a psychiatric illness. Baseline clinical, psychosis-risk status, cognitive, neurological-soft-signs measures, and dopamine-related-gene polymorphisms (DRD1-rs4532, COMT-rs165599, and DRD4-rs1800955) were collected in 138 young non-psychotic outpatients...
December 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28018685/coexistence-of-factor-vii-deficiency-and-hereditary-spastic-paraplegia-in-two-siblings
#4
Hortensia De la Corte-Rodriguez, E Carlos Rodriguez-Merchan, M Teresa Alvarez-Roman, Ana L Hernandez-Moreno
We present the case of two patients aged 12 years and 7 years who were referred to our hospital for factor VII deficiency inherited in an autosomal recessive pattern, who had suffered from previous multiple joint haemarthroses. They presented with fine motor symptoms and difficulty in walking. During physical examination we observed neurological symptoms (general hypotonia, muscular hypotrophy, exaggerated tendon reflexes, pes cavus, and spastic gait). Given that the symptoms were not justified by the deficiency of coagulation factor VII and on suspicion of hereditary spastic paraplegia (HSP), tests were carried out...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/28005910/melioidosis-in-malaysia-a-review-of-case-reports
#5
Paul Vijay Kingsley, Mark Leader, Nandika Suranjith Nagodawithana, Meghan Tipre, Nalini Sathiakumar
BACKGROUND: Melioidosis is a tropical infectious disease associated with significant mortality due to early onset of sepsis. OBJECTIVE: We sought to review case reports of melioidosis from Malaysia. METHODS: We conducted a computerized search of literature resources including PubMed, OVID, Scopus, MEDLINE and the COCHRANE database to identify published case reports from 1975 to 2015. We abstracted information on clinical characteristics, exposure history, comorbid conditions, management and outcome...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27989617/the-application-of-pbpk-models-in-estimating-human-brain-tissue-manganese-concentrations
#6
Siva P Ramoju, Donald R Mattison, Brittany Milton, Doreen McGough, Natalia Shilnikova, Harvey J Clewell, Miyoung Yoon, Michael D Taylor, Daniel Krewski, Melvin E Andersen
Mn is an essential element that causes neurotoxicity in humans when inhaled at high concentrations. This metal has well-recognized route-dependent differences in absorption, with greater proportionate uptake for inhalation versus dietary exposure. Physiologically-based pharmacokinetic (PBPK) models for Mn have included these route specific differences in uptake and their effect on delivery of Mn to target tissues via systemic circulation. These PBPK models include components describing ingestion and inhalation, homeostatic control (concentration dependent biliary elimination and gastrointestinal absorption), and delivery to target sites within the brain...
December 15, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27957879/lead-intoxication-due-to-ayurvedic-medications-as-a-cause-of-abdominal-pain-in-adults
#7
Varun Mehta, Vandana Midha, Ramit Mahajan, Vikram Narang, Praneet Wander, Ridhi Sood, Ajit Sood
BACKGROUND: Though a majority of cases of lead intoxication come from occupational exposures, traditional and folk remedies have also been reported to contain toxic amounts of lead. We present a large series of patients with lead poisoning due to intake of Ayurvedic medicines, all of whom presented with unexplained abdominal pain. METHODOLOGY: This was a retrospective, observational case series from a tertiary care center in India. The charts of patients who underwent blood lead level (BLL) testing as a part of workup for unexplained abdominal pain between 2005 and 2013 were reviewed...
December 13, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27942479/posterior-fossa-syndrome-a-narrative-review
#8
REVIEW
Salima S Wahab, Samantha Hettige, Kshtij Mankad, Kristian Aquilina
Posterior fossa syndrome (PFS), or cerebellar mutism syndrome (CMS), is a collection of neurological symptoms that occur following surgical resection of a posterior fossa tumour, and is characterised by either a reduction or an absence of speech. Some authors suggest that CM is only one symptom of the CMS complex that also includes ataxia, hypotonia and irritability as well as cranial nerve deficits, neurobehavioral changes and urinary retention or incontinence. It is seen almost exclusively in children. In 1985 Rekate et al...
October 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27940924/evidence-based-interventions-for-increasing-work-participation-for-persons-with-various-disabilities-a-systematic-review
#9
Diane L Smith, Katie Atmatzidis, Marisa Capogreco, Dominic Lloyd-Randolfi, Victoria Seman
Title I of the Americans With Disabilities Act prohibits discrimination in employment; however, 26 years later, employment rates for persons with disabilities hover at 34%. This systematic review investigates the effectiveness of evidence-based interventions to increase employment for people with various disabilities. Forty-six articles met the inclusion criteria for evidence-based interventions. The majority of studies assessed interventions for persons with mental health disabilities. Strong evidence was found for ongoing support and work-related social skills training prior to and during competitive employment for persons with mental health disabilities...
December 9, 2016: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/27936351/metal-exposures-at-three-u-s-electronic-scrap-recycling-facilities
#10
Diana Ceballos, Catherine Beaucham, Elena Page
Many metals found in electronic scrap are known to cause serious health effects, including but not limited to cancer and respiratory, neurologic, renal, and reproductive damage. The National Institute for Occupational Safety and Health/Centers for Disease Control and Prevention performed three health hazard evaluations at electronic scrap recycling facilities in the U.S. to characterize employee exposure to metals and recommend control strategies to reduce these exposures. We performed air, surface, and biological monitoring for metals...
December 9, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27930542/the-incidence-and-risk-factors-of-postoperative-neurological-deterioration-after-posterior-decompression-with-or-without-instrumented-fusion-for-thoracic-myelopathy
#11
Hui Wang, Lei Ma, Rui Xue, Dalong Yang, Tao Wang, Yanhong Wang, Sidong Yang, Wenyuan Ding
The aim of this study was to explore the incidence and risk factors of postoperative neurological deterioration after posterior decompression with or without instrumented fusion for thoracic myelopathy, and hope to provide references in decision-making and surgical planning for both spinal surgeon and thoracic stenosis patients.By retrieving the medical records from January 2001 to November 2015, 168 patients were retrospectively reviewed. According to the occurrence of postoperative neurological deterioration, patients were divided into 2 groups: neurological deterioration (ND) group and non-ND group...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27925608/active-music-therapy-and-physical-improvements-from-rehabilitation-for-neurological-conditions
#12
Demian Leandro Kogutek, Jeffrey David Holmes, Jessica Adrienne Grahn, Sara G Lutz, Emily Ready
Context • A variety of rehabilitation-based interventions are currently available for individuals with physical impairments resulting from neurological conditions, including physiotherapy, occupational therapy, and speech language pathology. Many individuals find participation in those therapies to be challenging. Alternative therapies have emerged as beneficial adjunctive treatments for individuals undergoing neurological rehabilitation, including music therapy (MT). Objective • The study intended to identify and collate systematically the evidence on MT interventions that address physical improvements in a rehabilitative setting...
October 2016: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/27923561/neuropathology-and-neurobehavioral-alterations-in-a-rat-model-of-traumatic-brain-injury-to-occupants-of-vehicles-targeted-by-underbody-blasts
#13
Flaubert Tchantchou, William L Fourney, Ulrich H Leiste, Joshua Vaughan, Parisa Rangghran, Adam Puche, Gary Fiskum
Many victims of blast-induced traumatic brain injury are occupants of military vehicles targeted by land mines. Recently improved vehicle designs protect these individuals against blast overpressure, leaving acceleration as the main force potentially responsible for brain injury. We recently developed a unique rat model of under-vehicle blast-induced hyperacceleration where exposure to acceleration as low as 50G force results in histopathological evidence of diffuse axonal injury and astrocyte activation, with no evidence of neuronal cell death...
December 5, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27892441/a-prospective-study-of-commonly-prescribed-drugs-in-the-management-of-neuropathic-pain-and-its-medication-adherence-pattern
#14
R Shrestha, P Silwal, N Basnet, S Shakya Shrestha, R Shrestha, B R Pokharel
Background Neuropathic pain is one of the common complains of patients visiting neurology and orthopedic departments in hospitals. Management of neuropathic pain is difficult and is often symptomatic rather than being curative. Adherence to medication is necessary for pain management to be effective. However, there are various factors related to patient, physician, drug regimen and other socio-economic affecting adherence. Objective To study commonly prescribed drugs in neuropathic pain management and the medication adherence pattern including its associated factors...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27881585/partial-interhemispheric-disconnection-syndrome-p-ihds-secondary-to-marchiafava-bignami-disease-type-b-mbd-b
#15
Carlo Canepa, Lorena Arias
A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement...
November 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27852879/examining-the-sources-of-occupational-stress-in-an-emergency-department
#16
S Basu, C Yap, S Mason
BACKGROUND: Previous work has established that health care staff, in particular emergency department (ED) personnel, experience significant occupational stress but the underlying stressors have not been well quantified. Such data inform interventions that can reduce cases of occupational mental illness, burnout, staff turnover and early retirement associated with cumulative stress. AIMS: To develop, implement and evaluate a questionnaire examining the origins of occupational stress in the ED...
December 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27846653/-assessment-of-occupational-problems-in-neurological-rehabilitation
#17
J D Rollnik, S B Schmidt, J Allmann, M Boltzmann
Introduction: The so-called Würzburg Screening (WS) is recommended for assessing occupational problems among rehabilitation patients. However, it is unclear whether it can be used in neurological rehabilitation. Data of the WS as well as of a medical opinion of occupational problems (both assessed at the beginning of rehabilitation) was compared with prognoses of occupation at the end of rehabilitation. Methods: Data of 347 neurological post-acute rehabilitation patients were analyzed. Data of the WS as well as of a medical opinion of occupational problems (both assessed at the beginning of rehabilitation) was compared with prognoses of occupation at the end of rehabilitation...
November 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27806425/-an-association-between-autonomy-and-national-ideology-the-founding-of-the-association-for-psychiatry-and-neurology-in-mecklenburg
#18
E Kumbier
Following the end of World War II, regional associations for psychiatry and neurology were founded in the Soviet Occupation Zone. Using the association in Mecklenburg as an example and considering the way society developed in the German Democratic Republic (GDR), it will be shown whether and to what degree these were increasingly subject to state control.
October 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27796833/neurotoxicity-effect-of-formaldehyde-on-occupational-exposure-and-influence-of-individual-susceptibility-to-some-metabolism-parameters
#19
Rezvan Zendehdel, Zohreh Fazli, Mohammad Mazinani
Over the years, neurotoxicity and cognitive dysfunction have separately been associated with endogenous formaldehyde and reduction of acetylcholine signals. However, a limited number of studies have shown a relationship between cholinergic neurotransmitter and formaldehyde exposure. Therefore, the aim of this study was to assess the neurological effect on workers from melamine-dish preparation workshop, who were exposed to formaldehyde. A total of 35 formaldehyde-exposed workers were compared with 32 control employees from the food industry...
November 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27795365/entry-of-botulinum-neurotoxin-subtypes-a1-and-a2-into-neurons
#20
Abby R Kroken, Faith C Blum, Madison Zuverink, Joseph T Barbieri
Botulinum neurotoxins (BoNTs) are the most toxic proteins for humans but also are common therapies for neurological diseases. BoNTs are dichain toxins, comprising an N-terminal catalytic domain (LC) disulfide bond linked to a C-terminal heavy chain (HC) which includes a translocation domain (HN) and a receptor binding domain (HC). Recently, the BoNT serotype A (BoNT/A) subtypes A1 and A2 were reported to possess similar potencies but different rates of cellular intoxication and pathology in a mouse model of botulism...
January 2017: Infection and Immunity
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