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https://www.readbyqxmd.com/read/29763291/classics-in-neuroimaging-the-serotonergic-2a-receptor-system-from-discovery-to-modern-molecular-imaging
#1
Elina T L'Estrade, Hanne D Hansen, Maria Erlandsson, Tomas G Ohlsson, Gitte M Knudsen, Matthias M Herth
Already in 1953, Woolley and Shaw speculated that serotonin could be involved in a range of central nervous system (CNS) disorders. Lysergic acid diethylamide (LSD) displayed an important role in this respect. It was used not only to antagonize biological effects of serotonin and to study the system itself, but also to identify serotonergic subtype receptors. The 5-HT2A receptor was discovered in the 1970s and identified as the responsible receptor mediating psychedelic effects of LSD. The development of positron emission tomography (PET) allowed to study this receptor system in vivo...
May 15, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29762283/five-to-ten-year-outcomes-of-operatively-treated-scapular-fractures
#2
Joscelyn M Tatro, Jeffrey A Gilbertson, Lisa K Schroder, Peter A Cole
BACKGROUND: The purpose of this study was to assess the 5 to 10-year clinical and patient-reported functional outcomes after open reduction and internal fixation (ORIF) of intra-articular and extra-articular scapular fractures. METHODS: We conducted a retrospective review of prospectively collected data on 106 patients who underwent ORIF of a scapular fracture at a single level-I trauma center between January 2005 and December 2010. Eight patients were excluded from the study because they had either severe neurologic injury or an isolated process fracture, and 66 patients (37 with an isolated extra-articular fracture and 29 with an intra-articular fracture) participated in the 5 to 10-year follow-up, yielding a follow-up rate of 67%...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29706172/effects-of-medication-assisted-treatment-mat-for-opioid-use-disorder-on-functional-outcomes-a-systematic-review
#3
Margaret A Maglione, Laura Raaen, Christine Chen, Gulrez Azhar, Nima Shahidinia, Mimi Shen, Ervant Maksabedian, Roberta M Shanman, Sydne Newberry, Susanne Hempel
This systematic review synthesizes evidence on the effects of Medication-Assisted Treatment (MAT) for opioid use disorder (OUD) on functional outcomes, including cognitive (e.g., memory), physical (e.g., fatigue), occupational (e.g., return to work), social/behavioral (e.g., criminal activity), and neurological (e.g., balance) function. Five databases were searched from inception to July 2017 to identify English-language controlled trials, case control studies, and cohort comparisons of one or more groups; cross-sectional studies were excluded...
June 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29701410/digital-artery-aneurysm-case-report
#4
José Vidoedo, José Teixeira
INTRODUCTION AND METHODS: A 71-year-old patient, housewife, with a history of hypertension, elevated cholesterol and hypotyroidism was referred to the outpatient clinic for tumefaction of the right hand 5th finger noticed 3-4 months earlier. She denied past or recent history of trauma, cardiac or infectious disease and had no familial history of aneurysmatic disease. She was asymptomatic except for local slight discomfort when she had to press or push something with her hand. She had no sensitivity or mobility impairment...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29688085/music-therapy-applied-to-complex-blast-injury-in-interdisciplinary-care-a-case-report
#5
Rebecca Vaudreuil, Luis Avila, Joke Bradt, Paul Pasquina
PURPOSE: Music therapy has a long history of treating the physiological, psychological, and neurological injuries of war. Recently, there has been an increase in the use of music therapy and other creative arts therapies in the care of combat injured service members returning to the United States from Iraq and Afghanistan, especially those with complex blast-related injuries. This case report describes the role of music therapy in the interdisciplinary rehabilitation of a severely injured service member...
April 24, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29664893/occupational-exposure-during-emergency-department-thoracotomy-a-prospective-multi-institution-study
#6
Andrew Nunn, Priya Prakash, Kenji Inaba, Alvarez Escalante, Zoë Maher, Seiji Yamaguchi, Dennis Y Kim, James Maciel, William C Chiu, Byron Drumheller, Joshua P Hazelton, Kaushik Mukherjee, Xian Luo-Owen, Rachel M Nygaard, Ashley P Marek, Bryan C Morse, Caitlin A Fitzgerald, Patrick L Bosarge, Randeep S Jawa, Susan E Rowell, Louis J Magnotti, Adrian W Ong, Tejal S Brahmbhatt, Michael D Grossman, Mark J Seamon
BACKGROUND: Occupational exposure is an important consideration during emergency department thoracotomy (EDT). While HIV/hepatitis prevalence in trauma patients (0-16.8%) and occupational exposure rates during operative trauma procedures (1.9-18.0%) have been reported, exposure risk during EDT is unknown. We hypothesized that occupational exposure risk during EDT would be greater than other operative trauma procedures. METHODS: A prospective, observational study at 16 US trauma centers was performed (2015-2016)...
April 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29623154/choosing-wisely-together-physical-and-occupational-therapy-consultation-for-acute-neurology-inpatients
#7
John C Probasco, Annette Lavezza, Andre Cassell, Tenise Shakes, Angie Feurer, Holly Russell, Hilary Sporney, Margie Burnett, Chepkorir Maritim, Victor Urrutia, H Adrian Puttgen, Michael Friedman, Erik H Hoyer
Background: Although many hospitalized neuroscience patients have physical and occupational therapy (rehabilitation) needs, patients with none or minimal physical impairments frequently receive rehabilitation consultation, diverting from patients with greatest need. Methods: A multidisciplinary team on the general and cerebrovascular neurology acute inpatient services mapped the rehabilitation consultation process, resulting in multiple implemented interventions including physician education on appropriate acute rehabilitation consultations, modification of multidisciplinary rounds, and discussion of patient rehabilitation needs throughout hospitalization...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29619928/studies-of-upper-limb-pain-in-occupational-medicine-in-general-practice-and-among-computer-operators
#8
Jørgen Riis Jepsen
Diagnostic consensus criteria cannot be applied in a major proportion of patients with upper limb complaints, many of which are regarded as "non-specific". The three empirical studies in this thesis aimed to address this diagnostic challenge by incorporating representative neurological qualities in the physical examination.
Patterns of muscle weakness, sensory abnormalities and nerve trunk allodynia based on the nerves' topography and their motor and cutaneous innervation were defined to reflect peripheral nerve afflictions and their locations...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29608920/the-metabotropic-glutamate-receptor-5-radioligand-11-c-azd9272-identifies-unique-binding-sites-in-primate-brain
#9
Katarina Varnäs, Anders Juréus, Sjoerd J Finnema, Peter Johnström, Patrick Raboisson, Nahid Amini, Akihiro Takano, Vladimir Stepanov, Christer Halldin, Lars Farde
The metabotropic glutamate receptor 5 (mGluR5) is a target for drug development and for imaging studies of the glutamate system in neurological and psychiatric disorders. [11 C]AZD9272 is a selective mGluR5 PET radioligand that is structurally different from hitherto applied mGluR5 radioligands. In the present investigation we compared the binding patterns of radiolabeled AZD9272 and other mGluR5 radioligands in the non-human primate (NHP) brain. PET studies were undertaken using [11 C]AZD9272 and the commonly applied mGluR5 radioligand [11 C]ABP688...
March 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29596925/association-of-pesticide-exposure-with-human-congenital-abnormalities
#10
REVIEW
Charikleia Kalliora, Charalampos Mamoulakis, Eleni Vasilopoulos, George A Stamatiades, Lydia Kalafati, Roza Barouni, Triantafyllia Karakousi, Mohammad Abdollahi, Aristidis Tsatsakis
Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017...
March 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29593207/chasing-the-chameleon-psychogenic-paraparesis-responding-to-non-invasive-brain-stimulation
#11
Simona Portaro, Demetrio Milardi, Antonino Naro, Antonio Chillura, Francesco Corallo, Angelo Quartarone, Rocco Salvatore Calabrò
Neurologic symptoms that develop unconsciously and are incompatible with known pathophysiologic mechanisms or anatomic pathways belong to Conversion Disorder (CD). CD diagnosis is based on the clinical history and the exclusion of physical disorders causing significant distress or social and occupational impairment. In a subgroup of CD, called functional weakness (FW), symptoms affecting limbs may be persistent, thus causing a permanent or transient loss of limb function. Physiotherapy, pharmacotherapy, hypnotherapy and repetitive transcranial magnetic stimulation (rTMS) have been proposed as treatment strategies for FW-CD...
March 30, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29570959/galantamine-memantine-combination-for-cognitive-impairments-due-to-electroconvulsive-therapy-traumatic-brain-injury-and-neurologic-and-psychiatric-disorders-kynurenic-acid-and-mismatch-negativity-target-engagement
#12
Maju Mathew Koola
Cognitive impairments due to electroconvulsive therapy (ECT), traumatic brain injury (TBI), and neurologic and psychiatric disorders are prevalent. Cholinergic and glutamatergic pathways, α-7 nicotinic acetylcholine (α-7nACh) receptor, and N-methyl-d-aspartate (NMDA) receptor are potential pathophysiologic mechanisms in all of these conditions. Galantamine not only is an acetylcholinesterase inhibitor but has a dual mode of action as a α-7nACh receptor modulator as well. Memantine is a noncompetitive NMDA receptor antagonist...
March 1, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29566236/is-disability-in-leprosy-still-a-burden-a-cross-sectional-study-in-a-rural-block-in-tamil-nadu-india
#13
Dinesh Kumar Ganesan, Logaraj Muthunarayanan
Background: Leprosy, a disease caused by Mycobacterium leprae, is an important cause of preventable disability. Methods: The present cross-sectional study was undertaken among leprosy-affected persons in a rural block in Kanchipuram District, Tamil Nadu, India in the year 2013. The sample included treatment completed leprosy affected persons ≥18 y of age. Persons with difficulty in cognition and those who were not willing to participate in the study were excluded...
March 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29562559/occupational-therapists-perspectives-on-binocular-diplopia-in-neurorehabilitation-a-national-survey
#14
Gillian Burgess, Vanessa D Jewell
BACKGROUND: Oculomotor dysfunction affects a significant number of adults with neurological conditions and binocular diplopia is a common symptom which impacts an individual's ability to participate in meaningful daily activities. Occupational therapists use partial and complete occlusion to minimize binocular diplopia, however a review of the literature reflected a lack of standardized protocol for each intervention technique. The purpose of this study was to examine occupational therapists' perspectives on the use of partial and complete occlusion and the clinical reasoning process used...
2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29553128/-exposure-to-organophosphate-pesticides-and-peripheral-polyneuropathy-in-workers-from-maule-region-chile
#15
Ángela Grillo Pizarro, Eduardo Achú Peralta, María Teresa Muñoz-Quezada, Boris Lucero Mondaca
OBJECTIVE: Organophosphate pesticides (OP) are used massively for their low cost and for their low environmental persistence and their high effectiveness in insect pest control, however, agricultural workers, when exposed to OP, have negative consequences on their health mainly neurological. For the first time, a research is reported in a Latin American population that studied the association between labor exposure to OP and the presence of peripheral polyneuropathy in agricultural workers...
March 22, 2018: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/29513840/comparative-analysis-of-mouse-inoculation-test-and-virus-isolation-in-cell-culture-for-rabies-diagnosis-in-animals-of-parana-brazil
#16
COMPARATIVE STUDY
Thaila Francini Corona, Beatriz Böger, Tatiana Carneiro da Rocha, Walfrido Külh Svoboda, Eliane Carneiro Gomes
INTRODUCTION: Rabies is an acute zoonotic disease, caused by a rhabdovirus that can affect all mammals, and is commonly transmitted by the bite of a rabid animal. The definitive diagnosis is laboratorial, by the Fluorescent Antibody Test (FAT) as a quick test and Mouse Inoculation Test (MIT) as a confirmatory test (gold standard). Studies conducted over the past three decades indicate that MIT and Virus Isolation in Cell Culture (VICC) can provide the same effectiveness, the latter being considered superior in bioethics and animal welfare...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29491481/the-spanish-version-of-face-name-associative-memory-exam-s-fname-performance-is-related-to-amyloid-burden-in-subjective-cognitive-decline
#17
Angela Sanabria, Montserrat Alegret, Octavio Rodriguez-Gomez, Sergi Valero, Oscar Sotolongo-Grau, Gemma Monté-Rubio, Carla Abdelnour, Ana Espinosa, Gemma Ortega, Alba Perez-Cordon, Anna Gailhajanet, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Ana Mauleon, Domingo Sanchez, Elvira Martin, Dorene M Rentz, Francisco Lomeña, Agustin Ruiz, Lluis Tarraga, Merce Boada
The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11 C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29482365/sub-acute-nickel-exposure-impairs-behavior-alters-neuronal-microarchitecture-and-induces-oxidative-stress-in-rats-brain
#18
Omamuyovwi Meashack Ijomone, Stephen Odey Okori, Olayemi Kafilat Ijomone, Azubike Peter Ebokaiwe
Nickel (Ni) is a heavy metal with wide industrial uses. Environmental and occupational exposures to Ni are potential risk factors for neurological symptoms in humans. The present study investigated the behavior and histomorphological alterations in brain of rats sub-acutely exposed to nickel chloride (NiCl2 ) and the possible involvement of oxidative stress. Rats were administered with 5, 10 or 20 mg/kg NiCl2 via intraperitoneal injections for 21 days. Neurobehavioral assessment was performed using the Y-maze and open field test (OFT)...
February 26, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29443779/cerebral-infarction-due-to-malposition-of-cervical-pedicle-screw-a-case-report
#19
Jun Zhang, Rongming Xu, Zheng Li, Weibin Zha
RATIONALE: Malposition of cervical pedicle screw (CPS) has a risk of vertebral artery (VA) injury which sometimes may cause unexpected and catastrophic outcome. A rare case of delayed onset of cerebral infarction caused by malposition of CPS was reported. PATIENT CONCERNS: A 23-year-old man who underwent a posterior cervical reduction and fusion of C4-5 using CPS fixation and allograft for cervical spine injury is presented. The patient suffered progressively weakness and numbness for both of upper and lower extremities 1 day after the operation...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29432246/evaluation-and-management-of-the-child-with-autism-spectrum-disorder
#20
Nicole Baumer, Sarah J Spence
PURPOSE OF REVIEW: Autism spectrum disorder is a neurodevelopmental disorder defined by deficits in social communication and the presence of restricted and repetitive behaviors and interests. This article provides the tools to diagnose and manage patients with autism spectrum disorder. RECENT FINDINGS: Autism spectrum disorder is a heterogeneous condition with varying presentations, multiple etiologies, and a number of comorbidities that impact the course and management of the disorder...
February 2018: Continuum: Lifelong Learning in Neurology
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