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https://www.readbyqxmd.com/read/28640596/drug-target-kinetics-in-drug-discovery
#1
Peter J Tonge
The development of therapies for the treatment of neurological cancer faces a number of major challenges including the synthesis of small molecule agents that can penetrate the blood brain barrier (BBB). Given the likelihood that in many cases drug exposure will be lower in the CNS than in systemic circulation, it follows that strategies should be employed that can sustain target engagement at low drug concentration. Time dependent target occupancy is a function of both the drug and target concentration as well as the thermodynamic and kinetic parameters that describe the binding reaction coordinate, and sustained target occupancy can be achieved through structural modifications that increase target (re)binding and/or that decrease the rate of drug dissociation...
June 22, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28628732/understanding-neurophobia-reasons-behind-impaired-understanding-and-learning-of-neuroanatomy-in-cross-disciplinary-healthcare-students
#2
Muhammad Asim Javaid, Shelly Chakraborty, John F Cryan, Harriët Schellekens, André Toulouse
Recent studies have highlighted a fear or difficulty with the study and understanding of neuroanatomy among medical and healthcare students. This has been linked with a diminished confidence of clinical practitioners and students to manage patients with neurological conditions. The underlying reasons for this difficulty have been queried among a broad cohort of medical, dental, occupational therapy, and speech and language sciences students. Direct evidence of the students' perception regarding specific difficulties associated with learning neuroanatomy has been provided and some of the measures required to address these issues have been identified...
June 19, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28624528/derivation-of-an-occupational-exposure-level-for-manganese-in-welding-fumes
#3
Lisa A Bailey, Laura E Kerper, Julie E Goodman
Exposure to high levels of manganese (Mn) in occupational settings is known to lead to adverse neurological effects. Since Mn is an essential nutrient, there are mechanisms that maintain its homeostatic control in the body, and there is some level of Mn in air that does not perturb Mn homeostasis. However, the Mn exposure concentrations at which no adverse effects are expected in occupational settings vary considerably across regulatory agencies. We set out to derive a Mn Occupational Exposure Level (OEL) for welders based on a review of studies that evaluated Mn exposure concentrations from welding fumes and: (1) neurological effects in welders; (2) levels of Mn in the brains of welders (via pallidal index [PI] estimated from magnetic resonance imaging [MRI]); (3) other biomarkers of Mn exposure in welders (i...
June 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28623144/cardiovascular-stress-during-inpatient-spinal-cord-injury-rehabilitation
#4
Dominik Zbogar, Janice J Eng, William C Miller, Andrei V Krassioukov, Mary C Verrier
OBJECTIVES: 1) To measure the amount of a) cardiovascular stress, b) self-reported physical activity and c) accelerometry-measured physical activity by individuals with SCI during physical therapy (PT) and occupational therapy (OT) and, 2) to investigate the relationship between these measures. DESIGN: Observational study. SETTING: Two inpatient SCI rehabilitation centres. PARTICIPANTS: SCI patients (n=87) were recruited from consecutive admissions to rehabilitation...
June 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28616739/petrol-filling-workers-as-biomonitor-of-pah-exposure-and-functional-health-capacity-in-resource-limited-settings-of-city-rawalpindi-pakistan
#5
Audil Rashid, Shu Taov, Ikhtiar Uddin, Atif Kamal
This is the first study from Pakistan to report the exposure of petrol filling workers (n = 120) to naphthalene (Nap) and pyrene (Pyr) in relation to their functional capacities and health outcome. A group of non-exposed subjects (controls n = 46) was also recruited for comparison. The perceived health risk of the exposed workers was monitored using a questionnaire based on the self-reporting survey. The observed physical anomalies related to the health disorder included the acidity after meals, eye redness, appetite loss, skin lesions, and dryness of oral cavity, while those related to neurasthenic symptoms included the body aches, energy loss, twitching, fatigue, sleeplessness, fainting, and irritability...
June 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28611164/fulminant-tumefactive-multiple-sclerosis-in-pregnancy
#6
Shabnam Pakneshan, Evanthia Bernitsas
A 35-year-old pregnant woman was admitted with acute onset of paresthesias and word finding difficulty. Initial MRI scan of the brain was suggestive of ischaemic event. During hospitalisation, she had a rapid course with worsening of her neurological deficit that prompted additional testing. Further investigations were consistent with tumefactive multiple sclerosis. After a poor initial response to intravenous steroids and plasma exchange, and discussion of all available therapeutic options, the patient decided to proceed with elective termination...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28610743/valproate-and-sodium-butyrate-attenuate-manganese-decreased-locomotor-activity-and-astrocytic-glutamate-transporters-expression-in-mice
#7
James Johnson, Edward Alain B Pajarillo, Equar Taka, Romonia Reams, Deok-Soo Son, Michael Aschner, Eunsook Lee
Manganese (Mn) is an essential trace element, but chronic overexposure to this metal, either environmentally or occupationally may cause manganism, a disease analogous to Parkinson's disease. Inhibitors of histone deacetylases, such as valproic acid (VPA) and sodium butyrate (NaB) exert neuroprotective effects in various animal models of neurological disorders. Thus, the present study investigated whether VPA or NaB prevent Mn-induced neurotoxicity by assessing locomotor activities and expression of astrocytic glutamate transporters, glutamate transporter 1 (GLT-1) and glutamate aspartate transporter (GLAST), in C57BL/6 mice...
June 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28605270/characteristics-of-acute-occupational-pesticide-exposures-in-texas-reported-to-poison-centers-2000-2015
#8
Amber Brooke Trueblood, Eva M Shipp
In the United States, there is limited literature on occupational pesticide exposures despite being associated with adverse health outcomes, including large states, such as Texas. The purpose of this paper is to characterize occupational pesticide poison center exposures in Texas. Descriptive statistics were used to describe exposures (e.g., exposure routes, type of pesticide, medical outcome, clinical effects, and temporal/seasonal patterns). From 2000 to 2015, there were 2,303 occupational pesticide poison center exposures...
June 12, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28604767/correlation-between-airborne-manganese-concentration-at-the-workstations-in-the-iron-foundry-and-manganese-concentration-in-workers-blood
#9
Seyedtaghi Mirmohammadi, Yosef Moghaddasi, Jamshid Yazdani, Razyeh Yousefinejad, Yahya Esfandyari, Mohsen Gorgani, Manijeh Habibpour
BACKGROUND: Manganese (Mn) used as raw material for melting process in the ferrous foundry is considered as hazardous neurotoxic substance because it accumulates in the central nervous system and may cause neurological disorders. The furnace-men and melting department workers are potentially exposed to manganese particles or fume in the workplace. The objective of the research has been to investigate the sources and levels of manganese exposure in the foundry by correlation of blood-manganese (B-Mn) and air-manganese (air-Mn) measurement...
June 12, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28572025/cobalt-toxicity-in-humans-a-review-of-the-potential-sources-and-systemic-health-effects
#10
REVIEW
Laura Leyssens, Bart Vinck, Catherine Van Der Straeten, Floris Wuyts, Leen Maes
Cobalt (Co) and its compounds are widely distributed in nature and are part of numerous anthropogenic activities. Although cobalt has a biologically necessary role as metal constituent of vitamin B12, excessive exposure has been shown to induce various adverse health effects. This review provides an extended overview of the possible Co sources and related intake routes, the detection and quantification methods for Co intake and the interpretation thereof, and the reported health effects. The Co sources were allocated to four exposure settings: occupational, environmental, dietary and medical exposure...
May 29, 2017: Toxicology
https://www.readbyqxmd.com/read/28549892/radial-head-arthroplasty-in-the-active-duty-military-service-member-with-minimum-2-year-follow-up
#11
John C Dunn, Nicholas A Kusnezov, Logan R Koehler, Emmanuel D Eisenstein, Kelly G Kilcoyne, Justin D Orr, Justin S Mitchell
PURPOSE: Radial head arthroplasty (RHA) is a viable treatment for complex radial head fracture. Whereas elbow stability and function is typically restored at short- to mid-term follow-up, the outcome in higher-demand populations is not well defined. We sought to characterize the functional and occupational outcomes following RHA in an active duty military population with intense upper extremity demands. METHODS: We retrospectively reviewed the records of all U.S...
May 24, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28538046/general-pediatrician-staffed-behavioral-developmental-access-clinic-decreases-time-to-evaluation-of-early-childhood-developmental-disorders
#12
Meghan Harrison, Persephone Jones, Iman Sharif, Matthew D Di Guglielmo
OBJECTIVE: To describe and evaluate the effectiveness of a quality improvement project to decrease wait time to evaluation for children referred to Developmental Behavioral Pediatricians (DBPs). METHODS: The authors created a Behavioral/Developmental Access Clinic (BDAC) staffed by a general pediatrician (GP) and pediatric psychologist. Clinicians in the BDAC provided comprehensive developmental evaluations for children in a discrete age range (<5 yr old). We describe the establishment of the BDAC along with referrals, diagnoses, and recommended follow-up for patients seen by the GP...
May 22, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28527504/telehealth-in-physical-medicine-and-rehabilitation-a-narrative-review
#13
REVIEW
Adam S Tenforde, Jaye E Hefner, Jodi E Kodish-Wachs, Mary A Iaccarino, Sabrina Paganoni
Telehealth refers to health care interactions that leverage telecommunication devices to provide medical care outside the traditional face-to-face, in-person medical encounter. Technology advances and research have expanded use of telehealth in health care delivery. Physical medicine and rehabilitation providers may use telehealth to deliver care to populations with neurologic and musculoskeletal conditions, commonly treated in both acute care and outpatient settings. Patients with impaired mobility and those living in locations with reduced access to care may particularly benefit...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28527229/effects-of-interactive-metronome-training-on-upper-extremity-function-adl-and-qol-in-stroke-patients
#14
Ga-Hui Yu, Jae-Shin Lee, Su-Kyoung Kim, Tae-Hyun Cha
BACKGROUND: Rhythm and timing training is stimulation that substitutes for a damaged function controls muscular movement or temporal element, which has positive impacts on the neurological aspect and movement of the brain. OBJECTIVE: This study is to assess the changes caused by rhythm and timing training using an interactive metronome (IM) on upper extremity function, ADL and QOL in stroke patients. METHODS: In order to assess the effects of IM training, a group experiment was conducted on 30 stroke patients...
May 19, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28508696/a-bibliometric-analysis-of-occupational-therapy-publications
#15
Ted Brown, Sharon A Gutman, Yuh-Shan Ho, Kenneth N K Fong
BACKGROUND: Bibliometrics involves the statistical analysis of the publications in a specific discipline or subject area. A bibliometric analysis of the occupational therapy refereed literature is needed. AIM: A bibliometric analysis was completed of the occupational therapy literature from 1991-2014, indexed in the Science Citation Index-Expanded or the Social Sciences Citation Index. METHOD: Publications were searched by title, abstract, keywords, and KeyWords Plus...
May 16, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28499736/-children-s-medically-complex-diseases-unit-a-model-required-in-all-our-hospitals
#16
Francisco José Climent Alcalá, Marta García Fernández de Villalta, Luis Escosa García, Aroa Rodríguez Alonso, Luis Adolfo Albajara Velasco
INTRODUCTION: The increase in survival of children with severe diseases has led to the rise of children with chronic diseases, sometimes with lifelong disabilities. In 2008, a unit for the specific care of medically complex children (MCC) was created in Hospital La Paz. OBJECTIVES: To describe the work and care activities of this Unit. Patients and methods An analysis was performed on all discharge reports of the Unit between January 2014 and July 2016. RESULTS: The MCC Unit has 6 beds and daily outpatient clinic...
May 9, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28498846/mecp2-recognizes-cytosine-methylated-tri-nucleotide-and-di-nucleotide-sequences-to-tune-transcription-in-the-mammalian-brain
#17
Sabine Lagger, John C Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H Ramsahoye, Miao Yu, Chuan He, Guido Sanguinetti, Lawrence C Sowers, Malcolm D Walkinshaw, Adrian Bird
Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the classical MeCP2 DNA recognition sequence, but additional methylated sequence targets have been reported. Here we show by in vitro and in vivo analyses that MeCP2 binding to non-CG methylated sites in brain is largely confined to the tri-nucleotide sequence mCAC. MeCP2 binding to chromosomal DNA in mouse brain is proportional to mCAC + mCG density and unexpectedly defines large genomic domains within which transcription is sensitive to MeCP2 occupancy...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28497086/the-effect-of-vibration-on-the-severity-of-restless-legs-syndrome-in-hemodialysis-patients
#18
Habibollah Hosseini, Majid Kazemi, Somayeh Azimpour
Introduction: The restless legs syndrome (RLS) is a neurological disorder in patients undergoing hemodialysis. This syndrome causes individual's disturbed rest, discomfort, and stress, and secondarily to weakened functioning and disturbance in occupational activities and familial life. Objectives: The present study aimed at investigate the effect of vibration on the severity of the manifestation of symptoms of RLS in hemodialysis patients. Patients and Methods: This is an interventional before-after study conducted on 80 patients with RLS in hemodialysis wards of Yazd hospitals...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28484867/regional-brain-volume-reduction-and-cognitive-outcomes-in-preterm-children-at-low-risk-at-9%C3%A2-years-of-age
#19
Ebru Arhan, Kıvılcım Gücüyener, Şebnem Soysal, Şafak Şalvarlı, M Ali Gürses, Ayşe Serdaroğlu, Ercan Demir, Ebru Ergenekon, Canan Türkyılmaz, Esra Önal, Esin Koç, Yıldız Atalay
OBJECTIVE: More information is needed on "low-risk" preterm infants' neurological outcome so that they can be included in follow-up programs. A prospective study was performed to examine the regional brain volume changes compared to term children and to assess the relationship between the regional brain volumes to cognitive outcome of the low-risk preterm children at 9 years of age. PATIENTS: Subjects comprised 22 preterm children who were determined to be at low risk for neurodevelopmental deficits with a gestational age between 28 and 33 weeks without a major neonatal morbidity in the neonatal period and 24 age-matched term control children term and matched for age, sex, and parental educational and occupational status...
May 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28483033/process-to-establish-11-primary-contact-allied-health-pathways-in-a-public-health-service
#20
Michelle Stute, Nicole Moretto, Maree Raymer, Merrilyn Banks, Peter Buttrum, Sonia Sam, Marita Bhagwat, Tracy Comans
Objective Faced with longstanding and increasing demand for specialist out-patient appointments that was unable to be met through usual medical consultant led care, Metro North Hospital and Health Service in 2014-15 established 11 allied health primary contact out-patient models of care.Methods The models involved six different allied health professions and nine specialist out-patient departments.Results All the allied health models have been endorsed for continuation following demonstration of their contribution to managing demand on specialist out-patient services...
May 9, 2017: Australian Health Review: a Publication of the Australian Hospital Association
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