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Complement receptor 3

Jian-Ping Xiao, Dao-Yang Wang, Xue-Rong Wang, Liang Yuan, Li Hao, De-Guang Wang
To investigate the clinical significance of the ratio of T helper cell 17 (Th17) cells to single immunoglobulin IL-1-related receptor (SIGIRR)+ cluster of differentiation (CD4)+ T cells in patients with systemic lupus erythematosus (SLE), novel data and data from previous studies were analyzed. The frequency of Th17 cells in peripheral blood mononuclear cells (PBMCs) and their correlation with clinical data were evaluated in 48 patients with SLE and 38 healthy controls through flow cytometry. Compared with healthy controls, the percentage of Th17 cells was significantly increased in the PBMCs of patients with SLE (Z=-5...
October 2018: Biomedical Reports
Rajesh Gupta, Dan C Nguyen, Michael D Schaid, Xia Lei, Appakalai N Balamurugan, G William Wong, Jeong-A Kim, James E Koltes, Michelle E Kimple, Sushant Bhatnagar
Secreted proteins are important metabolic regulators in both healthy and disease states. Here, we sought to investigate the mechanism by which the secreted protein complement-1q-like-3 (C1ql3) regulates insulin secretion from pancreatic β-cells, a key process affecting whole-body glucose metabolism. We found that C1ql3 predominantly inhibits exendin-4 and cAMP-stimulated insulin secretion from mouse and human islets. However, to a lesser extent, C1ql3 also reduced insulin secretion in response to KCl, the potassium channel blocker tolbutamide, and high glucose...
September 18, 2018: Journal of Biological Chemistry
Jiahua Guo, Hoa Thanh Nguyen, Shohei Ito, Kimika Yamamoto, Mirella Kanerva, Hisato Iwata
The occurrence of triclosan (TCS) in the eggs of wild avian species is an emerging concern. We previously evaluated the effects of in ovo exposure to TCS on the liver transcriptome of chicken embryos and proposed adverse outcome pathways (AOPs). However, the key molecular events identified to be affected need to be verified at the protein level. Herein, we investigated the changes in the spectrum of hepatic proteins in TCS-treated chicken embryos by proteomic analysis to validate the key signaling pathways involved in the AOPs...
September 13, 2018: Ecotoxicology and Environmental Safety
Thomas J Rogers, Jessica L Christenson, Lisa I Greene, Kathleen I O'Neill, Michelle M Williams, Michael A Gordon, Travis Nemkov, Angelo D'Alessandro, Greg D DeGala, Jimin Shin, Aik-Choon Tan, Diana M Cittelly, James R Lambert, Jennifer K Richer
Tryptophan-2,3-dioxygenase (TDO2), a rate-limiting enzyme in the tryptophan catabolism pathway, is induced in triple-negative breast cancer (TNBC) by inflammatory signals and anchorage-independent conditions. TNBC express extremely low levels of the microRNA-200 (miR-200) family compared to estrogen receptor-positive (ER+) breast cancer. In normal epithelial cells and ER+ breast cancers and cell lines, high levels of the family member, miR-200c serve to target and repress genes involved in epithelial-to-mesenchymal transition (EMT)...
September 13, 2018: Molecular Cancer Research: MCR
Marco Mirani, Giuseppe Favacchio, Eliseo Serone, Giuseppe Lucisano, Maria Chiara Rossi, Cesare C Berra
In the last years, due to new regulatory guidelines requiring a stringent documentation of cardiovascular (CV) safety of novel drugs for type 2 diabetes, cardiovascular outcomes safety trials (CVOTs) are requested. CVOTs increase the knowledge about the safety profile of the new drugs, but they have intrinsic limits that make difficult their transferability to clinical practice. For this reason, real world evidence is considered an important complement to experimental data. Among the glucagon-like peptide-1 receptor agonists, liraglutide in the LEADER CVOT demonstrated superiority in reducing the risk of major CV events (MACEs) vs...
September 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Mariusz Sikora, Lidia Rudnicka, Barbara Borkowska, Agnieszka Kardynał, Monika Słowińska, Adriana Rakowska, Olga Warszawik-Hendzel, Anna Wiergowska, Iwona Ługowska, Piotr Rutkowski, Tadeusz Dębniak, Jan Lubiński, Małgorzata Olszewska
Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive patients with melanoma. Genotyping was performed using real-time PCR. Results: Our data revealed modest association between xeroderma pigmentosum complementation group D (XPD) codon 312 polymorphism and tumor thickness (as defined by Breslow score; XPD D312N CC: 3...
2018: Journal of Cancer
Anthony K Redmond, Yuko Ohta, Michael F Criscitiello, Daniel J Macqueen, Martin F Flajnik, Helen Dooley
In mammals, haptoglobin (Hp) is an acute-phase plasma protein that binds with high affinity to hemoglobin (Hb) released by intravascular hemolysis. The resultant Hp-Hb complexes are bound and cleared by the scavenger receptor CD163, limiting Hb-induced oxidative damage. In this study, we show that Hp is a divergent member of the complement-initiating MASP family of proteins, which emerged in the ancestor of jawed vertebrates. We demonstrate that Hp has been independently lost from multiple vertebrate lineages, that characterized Hb-interacting residues of mammals are poorly conserved in nonmammalian species maintaining Hp, and that the extended loop 3 region of Hp, which mediates CD163 binding, is present only in mammals...
September 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Jeroen D Langereis, Michiel van der Flier, Marien I de Jonge
Patients with primary immunoglobulin deficiency have lower immunoglobulin levels or decreased immunoglobulin function, which makes these patients more susceptible to bacterial infection. Most prevalent are the selective IgA deficiencies (~1:3,000), followed by common variable immune deficiency (~1:25,000). Agammaglobulinemia is less common (~1:400,000) and is characterized by very low or no immunoglobulin production resulting in a more severe disease phenotype. Therapy for patients with agammaglobulinemia mainly relies on prophylactic antibiotics and the use of IgG replacement therapy, which successfully reduces the frequency of invasive bacterial infections...
2018: Frontiers in Immunology
Tetsuya Fujimoto, Shuji Aou
Perinatal exposure to bisphenol A (BPA) causes several alterations in brain function and behavior. In previous studies, we showed that prenatal treatment with low-level BPA impaired gender-specific behavior, enhanced depression-like behavior, and augmented behavioral responses to predator odor in rats. On this premise, we hypothesized that BPA-treated rats were more susceptible to predator odor stress. To test the potential neural mechanism underlying this effect, we conducted an electrophysiological study of neurons in the medial amygdala-a regional component of the olfactory pathway with high estrogen and androgen receptor expression, and thus a potential target of BPA-in rats exposed to BPA...
2018: Journal of Toxicological Sciences
Saori Inafuku, Garrett Klokman, Kip M Connor
Ischemia reperfusion (IR) injury induces retinal cell death and contributes to visual impairment. Previous studies suggest that the complement cascade plays a key role in IR injury in several systemic diseases. However, the role of the complement pathway in the ischemic retina has not been investigated. The aim of this study is to determine if the alternative complement cascade plays a role in retinal IR injury, and identify which components of the pathway mediate retinal degeneration in response to IR injury...
2018: Frontiers in Molecular Neuroscience
Matthew P Alexander, Steven N Fiering, Gary R Ostroff, Robert A Cramer, David W Mullins
β-Glucan is a naturally occurring glucose polysaccharide with immunostimulatory activity in both infection and malignancy. β-Glucan's antitumor effects have been attributed to the enhancement of complement receptor 3-dependent cellular cytotoxicity, as well as modulation of suppressive and stimulatory myeloid subsets, which in turn enhances antitumor T cell immunity. In the present study, we demonstrate antitumor efficacy of yeast-derived β-glucan particles (YGP) in a model of metastatic-like melanoma in the lung, through a mechanism that is independent of previously reported β-glucan-mediated antitumor pathways...
August 23, 2018: Cancer Immunology, Immunotherapy: CII
Fengming Ding, Ken-Ichi Oinuma, Nicole E Smalley, Amy L Schaefer, Omar Hamwy, E Peter Greenberg, Ajai A Dandekar
Pseudomonas aeruginosa uses two acyl-homoserine lactone signals and two quorum sensing (QS) transcription factors, LasR and RhlR, to activate dozens of genes. LasR responds to N -3-oxo-dodecanoyl-homoserine lactone (3OC12-HSL) and RhlR to N -butanoyl-homoserine lactone (C4-HSL). There is a third P. aeruginosa acyl-homoserine-lactone-responsive transcription factor, QscR, which acts to dampen or delay activation of genes by LasR and RhlR by an unknown mechanism. To better understand the role of QscR in P. aeruginosa QS, we performed a chromatin immunoprecipitation analysis, which showed this transcription factor bound the promoter of only a single operon of three genes linked to qscR , PA1895 to PA1897...
August 28, 2018: MBio
Hamid-Reza Kohan-Ghadr, Brian A Kilburn, Leena Kadam, Eugenia Johnson, Bradley L Kolb, Javier Rodriguez-Kovacs, Michael Hertz, D Randall Armant, Sascha Drewlo
Insufficient perfusion of the trophoblast by maternal blood is associated with an increased generation of reactive oxygen species (ROS) and complications of the placenta. In this study, we first examined whether rosiglitazone, an agonist of the peroxisome proliferator-activated receptor-γ (PPARγ), protects the human trophoblast from oxidative injury by regulating key antioxidant proteins, catalase (CAT) and the superoxide dismutases (SOD1 and SOD2). In first trimester placental explants, localization of CAT was limited to cytotrophoblasts, whereas SOD1 was expressed in both the cyto- and syncytiotrophoblasts...
August 18, 2018: Biology of Reproduction
Yansong Li, Zhangsheng Yang, Mikulas Chavko, Bin Liu, Olawale A Aderemi, Milomir O Simovic, Michael A Dubick, Leopoldo C Cancio
BACKGROUND AND OBJECTIVE: Complement activation as an early and important inflammatory process contributes to multiple organ dysfunction after trauma. We have recently shown that complement inhibition by decay-accelerating factor (DAF) protects brain from blast-overpressure (BOP)-induced damage. This study was conducted to determine the effect of DAF on acute lung injury induced by BOP exposure and to elucidate its possible mechanisms of action. METHODS: Anesthetized adult male Sprague-Daley rats were exposed to BOP (120 kPa) from a compressed air-driven shock tube...
2018: PloS One
S De Maat, Z L M Hofman, C Maas
We thank Drs Loffredo and Marone for their interest in our article and correspondence, which summarizes their impressive scientific contributions to the complex field of vascular biology. In our review, we provide an overview on the role of the plasma contact system, classically seen as part of the coagulation system, in hereditary angioedema [1]. The active role of the contact system in this pathology is evident, as both C1 esterase inhibitor C1INH deficiency and gain-of-function mutations in factor XII (FXII) result in hereditary angioedema...
August 21, 2018: Journal of Thrombosis and Haemostasis: JTH
Binbin Cheng, Wei-En Yuan, Jing Su, Yao Liu, Jianjun Chen
Immunotherapy has been increasingly utilized for the treatment of cancer. Currently available cancer immunotherapies mainly involve the use of antibodies, which have advantages in terms of pharmacodynamics such as efficacy and specificity, however, they exhibit disadvantages in regard to the pharmacokinetics including but not limited to poor tissue and tumor penetration, very long half-life, and the lack of oral bioavailability. Also they are immunogenic and may cause undesired side effects. In addition, they are difficult and expensive to produce...
August 13, 2018: European Journal of Medicinal Chemistry
Jessalyn M Hadfield, Elizabeth C Bowdridge, Ida Holásková, Ted H Elsasser, Robert A Dailey
Innate immune response to a lipopolysaccharide (LPS) challenge varies among sheep breeds. How different breeds respond to bacterial infections impacts management practices of sheep producers. Hence, clinical response, acute-phase response, and gene expression of pro- and anti-inflammatory markers in peripheral white blood cells (WBCs) were examined after an LPS challenge in Dorset and Suffolk ewes. Ewes received either PBS or 2.5 µg/kg LPS (i.v.) 4 to 5 d after onset of synchronized estrus. Blood was collected via jugular venipuncture intermittently for 24 h to determine WBC counts...
August 9, 2018: Journal of Animal Science
Takuya Osada, Zachary C Hartman, Junping Wei, Gangjun Lei, Amy C Hobeika, William R Gwin, Marcio A Diniz, Neil Spector, Timothy M Clay, Wei Chen, Michael A Morse, H Kim Lyerly
BACKGROUND: Upregulation of human epidermal growth factor receptor 3 (HER3) is a major mechanism of acquired resistance to therapies targeting its heterodimerization partners epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), but also exposes HER3 as a target for immune attack. We generated an adenovirus encoding full length human HER3 (Ad-HER3) to serve as a cancer vaccine. Previously we reported the anti-tumor efficacy and function of the T cell response to this vaccine...
August 9, 2018: Breast Cancer Research: BCR
Gabriela Canalli Kretzschmar, Luana Caroline Oliveira, Renato Mitsunori Nisihara, Thirumalaisamy P Velavan, Sérvio Túlio Stinghen, Ewalda R S Stahlke, Maria Luiza Petzl-Erler, Iara José T de Messias-Reason, Angelica Beate Winter Boldt
BACKGROUND: Pathophysiological mechanisms are still incompletely understood for leprosy, an urgent public health issue in Brazil. Complement receptor 1 (CR1) binds complement fragments C3b/C4b deposited on mycobacteria, mediating its entrance in macrophages. We investigated CR1 polymorphisms, gene expression and soluble CR1 levels in a case-control study with Brazilian leprosy patients, aiming to understand the role of this receptor in differential susceptibility to the disease. METHODOLOGY: Nine polymorphisms were haplotyped by multiplex PCR-SSP in 213 leprosy patients (47% multibacillary) and 297 controls...
August 2018: PLoS Neglected Tropical Diseases
Russell S Fraser, Luis G Arroyo, Ann Meyer, Brandon N Lillie
Collagenous lectins are a family of soluble pattern recognition receptors that play an important role in innate immune resistance to infectious disease. Through recognition of carbohydrate motifs on the surface of pathogens, some collagenous lectins can activate the lectin pathway of complement, providing an effective means of host defense. Genetic polymorphisms in collagenous lectins have been shown in several species to predispose animals to a variety of infectious diseases. Infectious diseases are an important cause of morbidity in horses, however little is known regarding the role of equine collagenous lectins...
August 2018: Veterinary Immunology and Immunopathology
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