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https://www.readbyqxmd.com/read/29453187/quality-of-web-based-educational-interventions-for-clinicians-on-human-papillomavirus-vaccine-content-and-usability-assessment
#1
Brittany L Rosen, James M Bishop, Skye L McDonald, Jessica A Kahn, Gary L Kreps
BACKGROUND: Human papillomavirus (HPV) vaccination rates fall far short of Healthy People 2020 objectives. A leading reason is that clinicians do not recommend the vaccine consistently and strongly to girls and boys in the age group recommended for vaccination. Although Web-based HPV vaccine educational interventions for clinicians have been created to promote vaccination recommendations, rigorous evaluations of these interventions have not been conducted. Such evaluations are important to maximize the efficacy of educational interventions in promoting clinician recommendations for HPV vaccination...
February 16, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29452363/structuremapper-a-high-throughput-algorithm-for-analyzing-protein-sequence-locations-in-structural-data
#2
Anssi Nurminen, Vesa P Hytönen, Alfonso Valencia
Motivation: StructureMapper is a high-throughput algorithm for automated mapping of protein primary amino sequence locations to existing three-dimensional protein structures. The algorithm is intended for facilitating easy and efficient utilization of structural information in protein characterization and proteomics. StructureMapper provides an analysis of the identified structural locations that includes surface accessibility, flexibility, protein-protein interfacing, intrinsic disorder prediction, secondary structure assignment, biological assembly information, and sequence identity percentages, among other metrics...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29451611/factors-associated-with-hiv-co-infection-in-cases-of-acquired-syphilis-reported-in-a-reference-center-for-sexually-transmitted-diseases-and-aids-in-the-municipality-of-s%C3%A3-o-paulo-brazil-2014
#3
Carla Gianna Luppi, Solange Eduardo Chabu Gomes, Roberto José Carvalho da Silva, Amanda Miyako Ueno, Anna Maria Kamimura Dos Santos, Ângela Tayra, Renata Ferreira Takahashi
OBJECTIVE: to describe sociodemographic and behavioral characteristics and to identify factors associated with human immunodeficiency virus (HIV) co-infection in cases of acquired syphilis reported in a Reference Center for Sexually Transmitted Diseases (STD) and AIDS. METHODS: cross-sectional study with secondary data from a Reference Center for STD and AIDS in the municipality of São Paulo, Brazil, in 2014; the Poisson regression was used to estimate prevalence ratios (PR) and 95% confidence intervals (95%CI)...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29448963/academic-medical-centers-as-innovation-ecosystems-to-address-population-omics-challenges-in-precision-medicine
#4
REVIEW
Patrick J Silva, Valerie M Schaibley, Kenneth S Ramos
While the promise of the Human Genome Project provided significant insights into the structure of the human genome, the complexities of disease at the individual level have made it difficult to utilize -omic information in clinical decision making. Some of the existing constraints have been minimized by technological advancements that have reduced the cost of sequencing to a rate far in excess of Moore's Law (a halving in cost per unit output every 18 months). The reduction in sequencing costs has made it economically feasible to create large data commons capturing the diversity of disease across populations...
February 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29447416/managing-opioid-use-disorder-and-co-occurring-posttraumatic-stress-disorder-among-veterans
#5
Rhonda Snow, Stephanie T Wynn
Support and safety measures are essential for Veterans admitted to acute psychiatric units with co-occurring posttraumatic stress disorder (PTSD) and opioid use disorder (OUD) to avoid unpleasant withdrawal symptoms. A human patient simulator was used to train clinicians to recognize opioid withdrawal symptoms. Clinicians were educated to assess for opioid withdrawal symptoms using the Clinical Opiate Withdrawal Scale. Knowledge was evaluated via pre/posttest. All participants' (N = 12) posttest scores improved...
February 15, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29447397/barriers-and-facilitators-of-diabetes-services-in-nepal-a-qualitative-evaluation
#6
Nicole Ide, James P LoGerfo, Biraj Karmacharya
For the past three decades, the burden of diabetes in Nepal has been steadily increasing, with an estimated 3% annual increase since the year 2000. Although the burden is increasing, the methods of addressing the challenge have remained largely unchanged. This study sought to assess the current state of diabetes services provided by health facilities and to identify the major barriers that people with diabetes commonly face in Nepal. For this qualitative study, we selected five health facilities of varying levels and locations...
February 13, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29447220/the-relationship-between-context-structure-and-processes-with-outcomes-of-6-regional-diabetes-networks-in-europe
#7
Mahdi Mahdavi, Jan Vissers, Sylvia Elkhuizen, Mattees van Dijk, Antero Vanhala, Eleftheria Karampli, Raquel Faubel, Paul Forte, Elena Coroian, Joris van de Klundert
BACKGROUND: While health service provisioning for the chronic condition Type 2 Diabetes (T2D) often involves a network of organisations and professionals, most evidence on the relationships between the structures and processes of service provisioning and the outcomes considers single organisations or solo practitioners. Extending Donabedian's Structure-Process-Outcome (SPO) model, we investigate how differences in quality of life, effective coverage of diabetes, and service satisfaction are associated with differences in the structures, processes, and context of T2D services in six regions in Finland, Germany, Greece, Netherlands, Spain, and UK...
2018: PloS One
https://www.readbyqxmd.com/read/29443325/a-survey-on-integrated-management-of-neonatal-and-childhood-illness-implementation-by-nurses-in-four-districts-of-west-arsi-zone-of-ethiopia
#8
Sheka Shemsi Seid, Endalew Gemechu Sendo
Background: In Ethiopia, one in 17 children dies before 1 year of age and one in 11 children dies before 5 years. Research that examines the factors influencing the implementation of the Integrated Management of Neonatal and Childhood Illnesses (IMNCI) strategy in Ethiopia is limited. This study aimed to identify the factors compelling the execution of IMNCI by nurses in four districts of West Arsi zone of Ethiopia. Methods: A mixed-method cross-sectional study was conducted from February to March 2016 in West Arsi zone of Oromia regional state, Ethiopia...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29441647/methods-for-addressing-innocent-bystanders-when-evaluating-safety-of-concomitant-vaccines
#9
Shirley V Wang, Abdurrahman Abdurrob, Julia Spoendlin, Edwin Lewis, Sophia R Newcomer, Bruce Fireman, Matthew F Daley, Jason M Glanz, Jonathan Duffy, Eric S Weintraub, Martin Kulldorff
PURPOSE: The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. This paper addresses a methodological challenge for observational studies using a self-controlled design to investigate the safety of concomitant vaccination...
February 13, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29441503/utilization-of-intergovernmental-funds-to-implement-maternal-and-child-health-plans-of-a-multi-strategy-community-intervention-in-haryana-north-india-a-retrospective-assessment
#10
Madhu Gupta, Federica Angeli, Hans Bosma, Shankar Prinja, Manmeet Kaur, Onno C P van Schayck
INTRODUCTION: A multi-strategy community intervention known as the National Rural Health Mission (NRHM) was implemented in India from 2005 to 2012 in an attempt to reduce maternal and child mortality. OBJECTIVE: This study examined the extent to which the NRHM's maternal and child health (MCH) sector plans were implemented. We observed trends in how intergovernmental (use of central government funds by state governments) budgets were allocated and used to implement MCH plans in Haryana, India...
December 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29440320/left-of-bang-interventions-in-trauma-some-legal-implications-of-military-medical-prophylaxis
#11
Rain Liivoja
In the context of military medical care, Eisenstein and colleagues have introduced the notion 'left of bang intervention in trauma', which refers to interventions administered before trauma to reduce morbidity and mortality after injury. This paper responds to Eisenstein and colleagues' ethical analysis of such interventions, highlighting the difficulty in distinguishing between purely prophylactic and enhancing interventions. This response also addresses legal issues that arise from left of bang interventions under human rights law and the law of armed conflict, in particular the questions as to whether the consent of service members would need to be obtained and whether the adversary would as a consequence be authorised to resort to more injurious weapons...
February 13, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29439701/population-attributable-risk-of-key-modifiable-risk-factors-associated-with-non-exclusive-breastfeeding-in-nigeria
#12
Felix Akpojene Ogbo, Andrew Page, John Idoko, Kingsley E Agho
BACKGROUND: Non-exclusive breastfeeding (non-EBF) is a risk factor for many of the 2300 under-five deaths occurring daily in Nigeria - a developing country with approximately 40 million children. This study aimed to quantify and compare the attributable burden of key modifiable risk factors associated with non-EBF in Nigeria to inform strategic policy responses and initiatives. METHODS: Relative risk and exposure prevalence for selected modifiable risk factors were used to calculate population attributable fractions based on Nigeria Demographic and Health Surveys data for the period (1999-2013)...
February 13, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29439372/work-related-threats-and-violence-in-human-service-sectors-the-importance-of-the-psycho-social-work-environment-examined-in-a-multilevel-prospective-study
#13
Lars Peter Andersen, Annie Hogh, Karin Biering, Charlotte Ann Gadegaard
BACKGROUND: Threats and violence at work are major concerns for employees in many human service sectors. The prevention of work-related violence is a major challenge for employees and management. OBJECTIVE: The purpose of this study was to identify prospective associations between psycho-social work environment and work-related threats and violence in four high risk human service sectors. METHODS: Questionnaire data was collected from 3011 employees working at psychiatric wards, in the elder sector, in the Prison and Probation Service and at Special Schools...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29439065/protocol-for-a-prospective-school-based-standardisation-study-of-a-digital-social-skills-assessment-tool-for-children-the-paediatric-evaluation-of-emotions-relationships-and-socialisation-peers-study
#14
Emma J Thompson, Miriam H Beauchamp, Simone J Darling, Stephen J C Hearps, Amy Brown, George Charalambous, Louise Crossley, David Darby, Julian J Dooley, Mardee Greenham, Mohinder Jaimangal, Skye McDonald, Frank Muscara, Lyn Turkstra, Vicki A Anderson
BACKGROUND: Humans are by nature a social species, with much of human experience spent in social interaction. Unsurprisingly, social functioning is crucial to well-being and quality of life across the lifespan. While early intervention for social problems appears promising, our ability to identify the specific impairments underlying their social problems (eg, social communication) is restricted by a dearth of accurate, ecologically valid and comprehensive child-direct assessment tools...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439009/her2-testing-of-gastro-oesophageal-adenocarcinoma-a-commentary-and-guidance-document-from-the-association-of-clinical-pathologists-molecular-pathology-and-diagnostics-committee
#15
REVIEW
Newton A C S Wong, Fernanda Amary, Rachel Butler, Richard Byers, David Gonzalez, Harry R Haynes, Mohammad Ilyas, Manuel Salto-Tellez, Philippe Taniere
The use of biologics targeted to the human epidermal growth factor receptor 2 (HER2) protein is the latest addition to the armamentarium used to fight advanced gastric or gastro-oesophageal junction adenocarcinoma. The decision to treat with the biologic trastuzumab is completely dependent on HER2 testing of tumour tissue. In 2017, the College of American Pathologists, American Society for Clinical Pathology and the American Society of Clinical Oncology jointly published guidelines for HER2 testing and clinical decision making in gastro-oesophageal adenocarcinoma...
February 8, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29437756/pre-post-mixed-methods-feasibility-study-of-the-workingwell-mobile-support-tool-for-individuals-with-serious-mental-illness-in-the-usa-a-pilot-study-protocol
#16
Joanne Nicholson, Spenser M Wright, Alyssa M Carlisle
INTRODUCTION: Successful competitive employment has been found to be related to enhanced self-esteem, higher quality of life and reduced mental health service use for individuals living with serious mental illnesses (SMIs) including schizophrenia, bipolar disorder and major depression. The effectiveness of the individual placement and support model has been demonstrated in multiple randomised controlled trials in many countries. The management of stress, depression and anxiety in the workplace may be effectively enhanced through digital mental health interventions...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29437751/what-are-the-costs-associated-with-child-and-maternal-healthcare-within-australia-a-study-protocol-for-the-use-of-data-linkage-to-identify-health-service-use-and-health-system-and-patient-costs
#17
Emily J Callander, Haylee Fox
INTRODUCTION: The current literature in Australia demonstrates that there are variations in access and outcomes in perinatal care based on socioeconomic factors. However, little has been done looking at the level of out-of-pocket healthcare costs associated with perinatal care. The primary aim of this project will be to quantify health service use and out-of-pocket healthcare expenditure associated with childbearing and early childhood in Queensland, Australia. METHODS AND ANALYSIS: This project will build Australia's first model (called Maternal & Child Cost MOD) of out-of-pocket healthcare expenditure by using administrative data from the Queensland Perinatal Data Collection, of all childbearing women and their resultant children, who gave birth in Queensland between 1 July 2012 and 30 June 2016...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29436869/quality-of-web-based-family-building-information-for-lgbtq-individuals
#18
Fabiana M Kreines, Alex Farr, Frank A Chervenak, Amos Grünebaum
OBJECTIVE: The number of patients who seek health information on the internet is increasing. Rates are particularly high among lesbian, gay, bisexual, transgender and queer (LGBTQ) individuals, due to health care barriers. The aim of this study was to evaluate the quality and inclusivity of web-based information pertaining to LGBTQ family building. METHODS: The first 100 US-based websites pertaining to LGBTQ family building were identified through a terminology-based internet search...
February 13, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29436279/integrated-palliative-care-is-about-professional-networking-rather-than-standardisation-of-care-a-qualitative-study-with-healthcare-professionals-in-19-integrated-palliative-care-initiatives-in-five-european-countries
#19
Marlieke den Herder-van der Eerden, Jeroen van Wijngaarden, Sheila Payne, Nancy Preston, Lisa Linge-Dahl, Lukas Radbruch, Karen Van Beek, Johan Menten, Csilla Busa, Agnes Csikos, Kris Vissers, Jelle van Gurp, Jeroen Hasselaar
BACKGROUND: Integrated palliative care aims at improving coordination of palliative care services around patients' anticipated needs. However, international comparisons of how integrated palliative care is implemented across four key domains of integrated care (content of care, patient flow, information logistics and availability of (human) resources and material) are lacking. AIM: To examine how integrated palliative care takes shape in practice across abovementioned key domains within several integrated palliative care initiatives in Europe...
February 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29436053/human-immunodeficiency-virus-status-disclosure-and-education-for-children-and-adolescents-in-papua-new-guinea
#20
Thyna Orelly, Henry Welch, Edwin Machine, Wendy Pameh, Trevor Duke
AIM: How to provide human immunodeficiency virus (HIV) disclosure and awareness for children and young people has not been studied in Papua New Guinea or Pacific Island countries. We aimed to determine the current practices of HIV disclosure and evaluate whether an incremental disclosure education model, as recommended by World Health Organization (WHO), would increase children's knowledge about their condition and improve adherence to antiretroviral therapy (ART). METHODS: We enrolled HIV-infected children on ART whose parents consented, and we identified whether they were aware that they were HIV positive or not...
February 13, 2018: Journal of Paediatrics and Child Health
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