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Koji Hayashi, Rei Asano, Mamiko Sato, Yuka Nakaya, Asuka Suzuki, Naoko Takaku, Kouji Hayashi, Yasutaka Kobayashi
Apraxia of eyelid opening (AEO) is occasionally seen in Parkinson's disease (PD) or related diseases. However, many clinicians have trouble with the management of AEO by Parkinsonism. In this report, we describe a case of AEO in Parkinsonism improved by trihexyphenidyl (THP). The patient was a 64-year-old woman, who was previously healthy but developed bradykinesia. She was clinically diagnosed as PD due to an L-dopa challenge test, but no other detailed tests were performed. She started antiparkinsonian medications and her symptoms were improved at an early phase...
March 2024: Curēus
#2
REVIEW
Jan Koptielow, Emilia Szyłak, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Jan Kochanowicz, Alina Kułakowska, Monika Chorąży
A neurological condition called dystonia results in abnormal, uncontrollable postures or movements because of sporadic or continuous muscular spasms. Several varieties of dystonia can impact people of all ages, leading to severe impairment and a decreased standard of living. The discovery of genes causing variations of single or mixed dystonia has improved our understanding of the disease's etiology. Genetic dystonias are linked to several genes, including pathogenic variations of VPS16, TOR1A, THAP1, GNAL, and ANO3...
March 22, 2024: International Journal of Molecular Sciences
#3
JOURNAL ARTICLE
Shiyu Fu, Zhiquan Yang, Xinghui He, Dingyang Liu, Zhuanyi Yang, Junmei Zhang, Liangchao Du
OBJECTIVE: This study aimed to investigate the long-term efficacy and prognosis of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with benign essential blepharospasm (BEB) and complete Meige syndrome, and to search for the best therapeutic subregion within the GPi. MATERIALS AND METHODS: Data were collected for 36 patients with Meige syndrome who underwent bilateral GPi-DBS surgery at our hospital between March 2014 and February 2022...
April 9, 2024: Neuromodulation: Journal of the International Neuromodulation Society
#4
JOURNAL ARTICLE
Narendrakumar H Barad, Eoin Mulroy
INTRODUCTION: Cranial dystonias (CrD) are challenging to treat. Oral pharmacotherapy is often sub-optimal, while delicate anatomy and limited availability of skilled botulinum toxin injectors makes this approach risky, and often difficult to access; neurosurgical options e.g. deep brain stimulation, are high-risk in the elderly populations most affected. We observed significant improvement in CrD in 2 patients prescribed Zolpidem+Melatonin combination treatment for insomnia, and therefore trialled this treatment in a further 4 patients with CrD...
April 3, 2024: Journal of the Neurological Sciences
#5
JOURNAL ARTICLE
Jigyasha Timsina, Ashok Dinasarapu, Gamze Kilic-Berkmen, John Budde, Yun Ju Sung, Adam M Klein, Carlos Cruchaga, H A Jinnah
OBJECTIVES: The adult-onset focal dystonias are characterized by over-active muscles leading to abnormal movements. For most cases, the etiology and pathogenesis remain unknown. In the current study, unbiased proteomics methods were used to identify potential changes in blood plasma proteins. METHODS: A large-scale unbiased proteomics screen was used to compare proteins (N = 6,345) in blood plasma of normal healthy controls (N = 49) with adult-onset focal dystonia (N = 143) consisting of specific subpopulations of cervical dystonia (N = 45), laryngeal dystonia (N = 49), and blepharospasm (N = 49)...
April 5, 2024: Annals of Neurology
#6
A K Shukla, A Contadini, K Kazmir-Lysak, M Schnyder, C Gerspach, S A Pot
An approximately 1.5-year-old mixed breed heifer was presented for evaluation and treatment due to ocular pain affecting the right eye secondary to a live nematode within the anterior chamber. Ophthalmic examination revealed marked blepharospasm, evidence of chronic keratitis, uveitis, and a single, white, approximately 2.5 cm long, 0.5 mm thick, living parasite. The heifer underwent general anesthesia, and the parasite was removed using passive aqueous humor outflow following a stab incision into the anterior chamber...
March 22, 2024: Veterinary Ophthalmology
#7
JOURNAL ARTICLE
Grace A Bailey, Anna Rawlings, Fatemeh Torabi, W Owen Pickrell, Kathryn J Peall
While motor and psychiatric phenotypes in idiopathic dystonia are increasingly well understood, a few studies have examined the rate, type, and temporal pattern of other clinical co-morbidities in dystonia. Here, we determine the rates of clinical diagnoses across 13 broad systems-based diagnostic groups, comparing an overall idiopathic dystonia cohort, and sub-cohorts of cervical dystonia, blepharospasm, and dystonic tremor, to a matched-control cohort. Using the SAIL databank, we undertook a longitudinal population-based cohort study (January 1st 1994-December 31st 2017) using anonymised electronic healthcare records for individuals living in Wales (UK), identifying those diagnosed with dystonia through use of a previously validated algorithm...
March 21, 2024: Journal of Neurology
#8
JOURNAL ARTICLE
Sonda Kammoun, Mona Rekik, Kmar Maaloul, Saloua Ben Amor, Amira Trigui
INTRODUCTION: Ocular manifestations of Mycoplasma Pneumoniae infection are rare. We present a case of Mycoplasma Pneumoniae infection revealed by a recurrent retro-bulbar optic neuritis. CASE DESCRIPTION: A 38-year-old woman, initially treated for a typical retro-bulbar optic neuritis of the right eye with corticosteroid therapy at high doses, presented for a recurrent decreased vision in the same eye, associated with blepharospasm and conjunctival hyperemia. The etiological assessment revealed a recent Mycoplasma Pneumoniae infection...
November 5, 2023: La Tunisie Médicale
#9
JOURNAL ARTICLE
Vittorio Velucci, Sarah Idrissi, Roberta Pellicciari, Marcello Esposito, Assunta Trinchillo, Daniele Belvisi, Giovanni Fabbrini, Gina Ferrazzano, Carmen Terranova, Paolo Girlanda, Giovanni Majorana, Vincenzo Rizzo, Francesco Bono, Giovanni Idone, Vincenzo Laterza, Laura Avanzino, Francesca Di Biasio, Roberta Marchese, Anna Castagna, Marina Ramella, Christian Lettieri, Sara Rinaldo, Maria Concetta Altavista, Luigi Polidori, Laura Bertolasi, Maria Chiara Tozzi, Roberto Erro, Paolo Barone, Pierangelo Barbero, Roberto Ceravolo, Marcello Mario Mascia, Tommaso Ercoli, Antonella Muroni, Carlo Alberto Artusi, Maurizio Zibetti, Cesa Lorella Maria Scaglione, Anna Rita Bentivoglio, Maria Sofia Cotelli, Luca Magistrelli, Giovanni Cossu, Alberto Albanese, Giovanna Maddalena Squintani, Tommaso Schirinzi, Angelo Fabio Gigante, Luca Maderna, Roberto Eleopra, Antonio Pisani, Daniela Cassano, Marcello Romano, Marina Rizzo, Alfredo Berardelli, Giovanni Defazio
BACKGROUND: Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and a male preponderance in limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether sex-related differences exist in expressing other dystonia-associated features and dystonia spread. OBJECTIVE: To provide accurate information on the relationship between sex differences, motor phenomenology, dystonia-associated features and the natural history of IAOD...
March 1, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#10
JOURNAL ARTICLE
Jinping Xu, Xiaodong Zhang, Qinxiu Cheng, Haoran Zhang, Linchang Zhong, Yuhan Luo, Yue Zhang, Zilin Ou, Zhicong Yan, Kangqiang Peng, Gang Liu
Blepharospasm is a common form of focal dystonia characterized by excessive and involuntary spasms of the orbicularis oculi. In addition to idiopathic blepharospasm, lesions in various brain regions can also cause acquired blepharospasm. Whether these two types of blepharospasm share a common brain network remains largely unknown. Herein, we performed lesion coactivation network mapping, based on meta-analytic connectivity modeling, to test whether lesions causing blepharospasm could be mapped to a common coactivation brain network...
February 9, 2024: Parkinsonism & related Disorders
#11
JOURNAL ARTICLE
Justine Cuinat, Bettina Debû, Sara Meoni, Pierre Pelissier, Anna Castrioto, Valérie Fraix, Elena Moro
BACKGROUND: The impact of focal dystonia on gait has attracted little attention and remains elusive. Considering the importance of both visual and head control in gait, blepharospasm and cervical dystonia should affect gait. Improvement of cervical/eyelid control following botulinum toxin (BTX) injections would translate into gait changes. OBJECTIVES: To assess gait differences in people with focal dystonia before and after BTX treatment. METHODS: Ten patients with blepharospasm, 10 patients with cervical dystonia, and 20 healthy age- and gender-matched controls were included...
February 2024: Movement Disorders Clinical Practice
#12
JOURNAL ARTICLE
Sarah Idrissi, Vittorio Velucci, Marcello Esposito, Assunta Trinchillo, Francesco Habestwallner, Daniele Belvisi, Giovanni Fabbrini, Gina Ferrazzano, Vincenzo Rizzo, Carmen Terranova, Paolo Girlanda, Roberta Pellicciari, Laura Avanzino, Francesca Di Biasio, Roberta Marchese, Francesco Bono, Giovanni Idone, Vincenzo Laterza, Christian Lettieri, Sara Rinaldo, Roberto Eleopra, Anna Castagna, Maria Concetta Altavista, Vincenzo Moschella, Roberto Erro, Paolo Barone, Pierangelo Barbero, Roberto Ceravolo, Sonia Mazzucchi, Marcello Mario Mascia, Tommaso Ercoli, Antonella Muroni, Maurizio Zibetti, Leonardo Lopiano, Cesa Lorella Maria Scaglione, Anna Rita Bentivoglio, Martina Petracca, Luca Magistrelli, Maria Sofia Cotelli, Giovanni Cossu, Giovanna Maddalena Squintani, Tiziana De Santis, Tommaso Schirinzi, Salvatore Misceo, Antonio Pisani, Alfredo Berardelli, Giovanni Defazio
A few earlier observations and recent controlled studies pointed to the possible contribution of thyroid diseases in idiopathic adult-onset dystonia (IAOD). The aim of this study was to investigate the association between thyroid status and clinical characteristics of IAOD, focusing on dystonia localization, spread, and associated features such as tremors and sensory tricks. Patients were identified from those included in the Italian Dystonia Registry, a multicentre dataset of patients with adult-onset dystonia...
February 20, 2024: Journal of Neural Transmission
#13
JOURNAL ARTICLE
Lygia Silva Galeno, Alice Regina Silva Lopes, José Ribamar da Silva Júnior, Ana Lúcia Abreu-Silva, Tiago Barbalho Lima
BACKGROUND AND AIM: Hydrodissection is a liquid injection technique that is rarely used in animal ophthalmic procedures. The use of this technique in the creation of conjunctival flaps for the treatment of corneal ulcers in dogs can improve the outcome, task, and comfort for patients. This study aimed to evaluate the use of hydrodissection in the creation of conjunctival flaps in dogs with corneal ulcers. MATERIALS AND METHODS: This study focused on a surgical procedure for creating conjunctival flaps in the eyes of 17 dogs with deep corneal ulcers...
December 2023: Veterinary World
#14
JOURNAL ARTICLE
Anna Leszczynska, Danuta Nowicka, Lutz E Pillunat, Jacek C Szepietowski
Botulinum toxin (BoNT) has been known for over 50 years. It has conquered many areas of medicine and has become indispensable in contemporary medicine. Now, BoNT is used to treat at least 26 conditions in six medical specialties. Although the use of BoNT began in strabology, it became the gold standard for many ophthalmologic pathologies. The present review of the literature focuses on the use of BoNT in ophthalmology and treatment of the following conditions: blepharospasm, facial hemispasm, facial palsy, spastic entropion, strabismus, endocrine orbitopathy, convergence spasm, and facial trauma...
February 5, 2024: Indian Journal of Ophthalmology
#15
REVIEW
Giovanni Defazio, Antonella Muroni, Paolo Taurisano, Angelo Fabio Gigante, Michela Fanzecco, Davide Martino
BACKGROUND: Cognitive dysfunction has been reported in idiopathic adult-onset dystonia (IAOD), but whether this is a primary or secondary component of the disorder remains uncertain. OBJECTIVE: Here, we aimed to analyze the key domains of abnormal cognitive performance in IAOD and whether this is associated with motor or mood changes. METHODS: Article selection for our critical review was guided by PRISMA guidelines (mesh terms "dystonia" and "cognitive," publication period: 2000-2022)...
February 5, 2024: Movement Disorders Clinical Practice
#16
JOURNAL ARTICLE
Gamze Kilic-Berkmen, Hodam Kim, Dongdong Chen, Cameron I Yeo, Ashok R Dinasarapu, Laura M Scorr, Woon-Hong Yeo, David A Peterson, Hilde Williams, April Ruby, Roger Mills, H A Jinnah
BACKGROUND: Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results is sometimes challenging. OBJECTIVE: The aim is to conduct an exploratory trial of oral dipraglurant for blepharospasm. METHODS: This study was an exploratory, phase 2a, randomized, double-blind, placebo-controlled trial of 15 participants who were assigned to receive a placebo or dipraglurant (50 or 100 mg) and assessed over 2 days, 1 and 2 hours following dosing...
February 3, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#17
JOURNAL ARTICLE
Rodrigo Alencar E Silva, Pedro Fraiman, Clécio de Oliveira Godeiro Júnior
BACKGROUND: The application of botulinum toxin (BoNT) in the treatment of blepharospasm and hemifacial spasm (HS) is a well-established practice. However, neurology residency programs often rely on real patients for training, which has limitations in terms of patient availability and skill acquisition. OBJECTIVE: Assess the efficacy of a new facial phantom model for acquiring motor skills in BoNT application. METHODS: An anthropomorphic facial phantom model was developed in collaboration with a medical training simulator start-up...
January 2024: Arquivos de Neuro-psiquiatria
#18
JOURNAL ARTICLE
Alexandra Bergen, James Herrmann, Christopher M Reilly
OBJECTIVE: To evaluate the clinical and histopathological features of a case of xanthogranulomatous keratitis in a mixed-breed dog. ANIMAL: Mixed-breed dog. CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES: An 11-year-old spayed female mixed-breed dog was presented for mild blepharospasm, corneal cloudiness, and increasing conjunctival hyperemia OD. Ophthalmic examination revealed multifocal pink and cream-colored consolidated corneal infiltrative lesions and generalized neovascularization with suspected diagnosis of stromal abscessation...
April 1, 2024: Journal of the American Veterinary Medical Association
#19
Galih Indra Permana, Takashi Morishita, Hideaki Tanaka, Hitoshi Iida, Shinsuke Fujioka, Hiroshi Abe
BACKGROUND: Tourette syndrome (TS) is a neurologic condition characterized by motor and phonic tics. Dystonic tics, including blepharospasm, are considered atypical or unusual in severe TS. CASE REPORT: We report a severe case of TS with facial dystonic tics resembling blepharospasm in which the microlesion effect and a sustained therapeutic effect was observed with bilateral globus pallidus interna (GPi) deep brain stimulation (DBS). DISCUSSION: Bilateral GPi DBS can be beneficial for blepharospasm-like tics and severe symptoms of TS...
2024: Tremor and Other Hyperkinetic Movements
#20
Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/6876327.].
2024: Oxidative Medicine and Cellular Longevity
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