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Blepharospasm

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https://www.readbyqxmd.com/read/27919237/a-novel-ano3-variant-identified-in-a-53-year-old-woman-presenting-with-hyperkinetic-dysarthria-blepharospasm-hyperkinesias-and-complex-motor%C3%A2-tics
#1
Patrick R Blackburn, Michael T Zimmermann, Jennifer M Gass, Kimberly G Harris, Margot A Cousin, Nicole J Boczek, Owen A Ross, Eric W Klee, Paul W Brazis, Jay A Van Gerpen, Paldeep S Atwal
BACKGROUND: Cervical dystonias have a variable presentation and underlying etiology, but collectively represent the most common form of focal dystonia. There are a number of known genetic forms of dystonia (DYT1-27); however the heterogeneity of disease presentation does not always make it easy to categorize the disease by phenotype-genotype comparison. CASE PRESENTATION: In this report, we describe a 53-year-old female who presented initially with hand tremor following a total hip arthroplasty...
December 5, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27913194/genetic-screening-of-thap1-in-primary-dystonia-patients-of-india
#2
Subhajit Giri, Tufan Naiya, Zaffar Equbal, Charulata Savant Sankhla, Shyamal Kumar Das, Kunal Ray, Jharna Ray
BACKGROUND: Primary Dystonia is a common movement disorder manifested by dystonic symptoms only. DYT6, a major genetic factor, plays a significant role in primary pure dystonia pathogenesis. In this study we analyzed THAP1 (DYT 6) gene in primary pure dystonia patients, which has been widely studied in other populations but not in Indians. METHODS: The study cohort contained 227 index primary pure dystonia patients with the involvement of cervical region and 254 neurologically control individuals collected from East Indian population...
November 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27816991/frontalis-suspension-surgery-to-treat-patients-with-blepharospasm-and-eyelid-opening-apraxia-long-term-results
#3
Dirk Dressler, Chrisanthi Karapantzou, Saskia Rohrbach, Simon Schneider, Rainer Laskawi
Blepharospasm may be accompanied by eyelid opening apraxia (EOA) reducing the efficacy of botulinum toxin (BT) therapy. The frontalis suspension operation (FSO) is then the only effective treatment option available. We want to report the first long-term results with FSO. We studied 15 patients with blepharospasm and EAO unresponsive to BT therapy (9 females, 6 males, age 61.9 ± 11.5 years). FSO was performed by applying 2 polytetrafluoroethylene threads (PTFE, Gore-Tex(®)) per eye connecting the frontalis muscle to the upper eye lid...
November 5, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27799829/bleb-incarceration-following-ahmed-valve-surgery
#4
Fredric J Gross, Giovanni DiSandro
Globe luxation is a painful and potentially vision-threatening condition in which the globe becomes trapped behind the eyelids requiring physician intervention in the emergency department or eye clinic. On presentation, the patient typically complains of an inability to close their eye, severe foreign body sensation, decreased vision, and significant eye pain. Although most visual symptoms are reversible and primarily result from exposure keratopathy, optic nerve damage, and permanent vision loss can occur from repeat or prolonged episodes of globe luxation...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27791324/effect-of-topical-ophthalmic-latanoprost-0-005-solution-alone-and-in-combination-with-diclofenac-0-1-solution-in-healthy-horses-a-pilot-study
#5
Kyle Tofflemire, Elizabeth M Whitley, Rachel Allbaugh, Gil Ben-Shlomo, Angela Griggs, Travis Strong, R David Whitley
OBJECTIVE: To evaluate the effect of topical ophthalmic 0.005% latanoprost alone and in combination with 0.1% diclofenac on healthy horses. ANIMALS STUDIED: Twelve healthy adult horses. PROCEDURES: A randomized, masked crossover design was used with horses divided into three groups for once daily treatment in one randomly selected eye. For arm 1 of the study, Group D (n = 3) received 0.1% diclofenac, Group L (n = 3) received 0.005% latanoprost, and Group DL (n = 6) received 0...
October 28, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27770067/objective-computerized-video-based-rating-of-blepharospasm-severity
#6
David A Peterson, Gwen C Littlewort, Marian S Bartlett, Antonella Macerollo, Joel S Perlmutter, H A Jinnah, Mark Hallett, Terrence J Sejnowski
OBJECTIVE: To compare clinical rating scales of blepharospasm severity with involuntary eye closures measured automatically from patient videos with contemporary facial expression software. METHODS: We evaluated video recordings of a standardized clinical examination from 50 patients with blepharospasm in the Dystonia Coalition's Natural History and Biorepository study. Eye closures were measured on a frame-by-frame basis with software known as the Computer Expression Recognition Toolbox (CERT)...
November 15, 2016: Neurology
https://www.readbyqxmd.com/read/27761118/sexual-well-being-in-patients-with-blepharospasm-spasmodic-torticollis-and-hemifacial-spasm-a-pilot-study
#7
Paola Perozzo, Adriana Salatino, Paolo Cerrato, Raffaella Ricci
Mood, anxiety, and other psychological symptoms are common in dystonic patients suffering from blepharospasm (BSP) and spasmodic torticollis (ST). Since sexual well-being is an important aspect of mental health, here, we investigated whether these patients may also experience a worsening of their sexual life. In particular, quality of sexual life was evaluated in patients suffering from BSP (N = 30), ST (N = 30), and in a control group of patient with Hemifacial spasm (HFS; N = 30), undergoing botulinum toxin type A therapy...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27719855/functional-facial-and-tongue-movement-disorders
#8
A Fasano, M Tinazzi
Functional movement disorders (FMDs) affecting the eyelids, tongue, and other facial muscles are often underrecognized because their phenomenology has not been fully characterized. Nevertheless, these disorders are more common than previously thought. In this chapter we will discuss the phenomenology as well as the clinical and instrumental diagnosis of facial FMDs. Facial FMDs should be considered when a patient exhibits any combination of the following features: (1) fixed unilateral facial contractions, especially with lower lip, with or without ipsilateral jaw involvement, of maximal severity at onset; (2) inconsistent features such as changes in side and pattern during or between examination; (3) associated somatoform or nonphysiologic sensory or motor findings; (4) reduction or abolition of facial spasm with distraction; (5) response to suggestion or psychotherapy; (6) rapid onset and/or spontaneous remissions; and (7) normal neurologic examination...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27647769/the-comparison-between-intradermal-injection-of-abobotulinumtoxina-and-normal-saline-for-face-lifting-a-split-face-randomized-controlled-trial
#9
Rungsima Wanitphakdeedecha, Chanida Ungaksornpairote, Arisa Kaewkes, Viboon Rojanavanich, Weeranut Phothong, Woraphong Manuskiatti
BACKGROUND: Botulinum toxin type A (BTA) has been approved for the treatment of strabismus, blepharospasm, muscle spasm, cervical dystonia, pain syndrome, glabella wrinkles, and severe primary axillary hyperhidrosis. Intradermal injection of BTA has been used off-label by many clinicians for the purpose of face-lifting effect. Few studies on onabotulinumtoxinA (ONA) demonstrated no clinical efficacy on face-lifting effect when comparing to normal saline solution (NSS). So far, there is no split-face comparison study on face-lifting effect of abobotulinumtoxinA (ABO)...
September 19, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27647704/epidemiological-clinical-and-genetic-aspects-of-adult-onset-isolated-focal-dystonia-in-ireland
#10
L Williams, E McGovern, O Kimmich, A Molloy, I Beiser, J S Butler, F Molloy, P Logan, D G Healy, T Lynch, R Walsh, L Cassidy, P Moriarty, H Moore, T McSwiney, C Walsh, S O'Riordan, M Hutchinson
BACKGROUND: Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. AIM: To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. METHODS: Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources...
September 19, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27627971/marked-improvement-of-meige-syndrome-in-a-japanese-male-patient-with-schizophrenia-after-switching-from-risperidone-to-paliperidone-a-case-report
#11
Reiji Yoshimura, Hikaru Hori, Asuka Katsuki, Kiyokazu Atake
Meige syndrome is a relatively rare type of oral facial dystonia. The dominant symptoms involve involuntary eye blinking and chin thrusting. Some patients may experience excessive tongue protrusion, squinting, muddled speech, or uncontrollable contraction of the platysma muscle. A 44-year-old Japanese male was suffering from schizophrenia. The initial presentation of his psychosis consisted of auditory hallucinations, delusions of persecution, psychomotor excitement, loosening association, and restlessness...
September 2016: Journal of UOEH
https://www.readbyqxmd.com/read/27624855/canine-ocular-onchocerciasis-a-retrospective-review-of-the-diagnosis-treatment-and-outcome-of-16-cases-in-new-mexico-2011-2015
#12
Nancy Johnstone McLean, Kimberly Newkirk, Coenraad M Adema
OBJECTIVE: To describe the clinical exam findings, treatment and outcomes of 16 dogs diagnosed with ocular onchocerciasis in New Mexico. MATERIALS AND METHODS: Records of dogs diagnosed by the primary author were reviewed (2011-2015). Records that were accessible and included a diagnosis of Onchocerca lupi by histopathologic or molecular identification of the nematode were included. RESULTS: Sixteen cases were included. 3/16 dogs were treated with year-round heartworm prophylaxis prior to infection...
September 13, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27621795/orbicularis-oculi-myectomy-as-a-treatment-for-blepharospasm-in-a-case-of-schwartz-jampel-syndrome
#13
Bahram Eshraghi, Mahla Shadravan, Elham Aalami, Elias Khalili Pour
PURPOSE: To describe a patient with Schwartz Jampel vel Aberfeld syndrome (SJS) who underwent orbicularis oculi myectomy as a treatment for blepharospasm. CASE REPORT: A 4-year-old child with SJS did not respond to an injection of a single dose of botulinum toxin after one month, so orbicularis myectomy was then performed under general anesthesia. During the procedure, orbicularis vermiform movements were a useful guide for the extent of myectomy that the patient needed...
July 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27607413/alleviating-maneuvers-for-benign-essential-blepharospasm-and-hemifacial-spasm
#14
Andrew G Lee, Neil R Miller
No abstract text is available yet for this article.
November 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27606483/use-of-alleviating-maneuvers-for-periocular-facial-dystonias
#15
Caroline L S Kilduff, Edward J Casswell, Tahrina Salam, Dov Hersh, Santiago Ortiz-Perez, Daniel Ezra
Importance: Patients with benign essential blepharospasm or hemifacial spasm are known to use botulinum toxin injections and alleviating maneuvers to help control their symptoms. The clinical correlates between the use of botulinum toxin injections and the use of alleviating maneuvers are not well established. Objective: To determine whether the use of alleviating maneuvers for benign essential blepharospasm or hemifacial spasm correlates with disease severity or botulinum toxin treatment...
September 8, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27580344/photophobia-in-primary-headaches-in-essential-blepharospasm-and-in-major-depression
#16
Evangelos Anagnostou, Michael Vikelis, Elias Tzavellas, Apostolia Ghika, Ioanna Kouzi, Ioannis Evdokimidis, Evangelia Kararizou
OBJECTIVES: Although photophobia is a well-known symptom in various disorders, it has rarely been studied explicitly and its definition in a clinical setting can be somewhat elusive. Here, we assessed photophobia with a common psychometric tool in different conditions, in which light intolerance is considered part of the syndrome. PATIENTS AND METHODS: A prospective study was undertaken in patients with migraine (MH), cluster headache (CH), tension-type headache (TH), essential blepharospasm (BS) and major depression (MD)...
August 31, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27533532/role-of-gabaergic-system-in-blepharospasm-response
#17
Craig Evinger, Kathleen Digre
No abstract text is available yet for this article.
September 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27533531/role-of-gabaergic-system-in-blepharospasm
#18
Yukihisa Suzuki, Kenji Ishii, Motohiro Kiyosawa
No abstract text is available yet for this article.
September 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27530616/incobotulinumtoxina-a-review-in-upper-limb-spasticity
#19
Yvette N Lamb, Lesley J Scott
Intramuscular incobotulinumtoxinA (Xeomin(®)) is indicated for the treatment or improvement of adult patients with upper limb spasticity (featured indication), cervical dystonia, blepharospasm and glabellar lines. It is a highly purified formulation of botulinum toxin type A that inhibits acetylcholine signalling at neuromuscular junctions, reducing muscle hypertonia. This narrative review discusses the clinical use of incobotulinumtoxinA in adults with upper limb spasticity and summarizes its pharmacological properties...
September 2016: Drugs
https://www.readbyqxmd.com/read/27526039/progressive-supranuclear-palsy-and-corticobasal-degeneration-pathophysiology-and-treatment-options
#20
REVIEW
Ruth Lamb, Jonathan D Rohrer, Andrew J Lees, Huw R Morris
There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms. The use of most pharmacological treatment options are based on experience in other disorders or from non-randomized historical controls, case series, or expert opinion. Levodopa may provide some improvement in symptoms of Parkinsonism (specifically bradykinesia and rigidity) in PSP and CBD; however, evidence is conflicting and where present, benefits are often negligible and short lived...
September 2016: Current Treatment Options in Neurology
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