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Blepharospasm

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https://www.readbyqxmd.com/read/28902964/plasmatic-coagulation-and-fibrinolysis-in-healthy-and-otostrongylus-affected-northern-elephant-seals-mirounga-angustirostris
#1
Sarrah Kaye, Shawn Johnson, Carlos Rios, Daniel J Fletcher
BACKGROUND: Prepatent Otostrongylus arteritis results in hemorrhagic diathesis in free-ranging Northern elephant seals (Mirounga angustirostris) attributed to aberrant larval migration of the lungworm, Otostrongylus circumlitus. Clinical signs are often nonspecific, including lethargy, anorexia, and blepharospasm, but can progress to spontaneous frank hemorrhage and death within 72 hours of onset. Previously published case reports describe coagulopathy with prolonged PT and APTT, normal to elevated platelet counts, normal antithrombin concentrations, and low concentrations of fibrinogen degradation products...
September 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28893588/resting-state-fmri-observations-of-baseline-brain-functional-activities-and-connectivities-in-primary-blepharospasm
#2
Ming-Fei Ni, Xiao-Feng Huang, Yan-Wei Miao, Zhan-Hua Liang
Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary eyelid spasms and blinking. The pathophysiology of BPS remains unclear. Several functional and structural neuroimaging studies have demonstrated abnormalities of sensorimotor structures such as the sensorimotor cortex, the basal ganglia, the thalamus and the cerebellum in BPS patients. However, some of the results of these studies were inconsistent. In addition, the relationship between the motor and sensory structures in patients with BPS still needs to be investigated...
September 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28888928/an-update-on-new-and-unique-uses-of-botulinum-toxin-in-movement-disorders
#3
Joseph Jankovic
The therapeutic applications of botulinum toxin (BoNT) have grown manifold since its initial approval in 1989 by the US Food and Drug Administration (FDA) for the treatment of strabismus, blepharospasm, and other facial spasms. Although it is the most potent biologic toxin known to man, long-term studies have established its safety in the treatment of a variety of neurologic and non-neurologic disorders. This review focuses on some novel and uncommon uses of BoNT in the treatment of movement disorders, such as oromandibular dystonia, including bruxism, anterocollis, camptocormia, tremor, tics, tardive and levodopa-induced dyskinesia, and restless legs syndrome...
September 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28884242/a-comparative-crossover-study-on-the-treatment-of-hemifacial-spasm-and-blepharospasm-preseptal-and-pretarsal-botulinum-toxin-injection-techniques
#4
Praween Lolekha, Arthita Choolam, Kongkiat Kulkantrakorn
Hemifacial spasm (HFS) and benign essential blepharospasm (BEB) are chronic and disabling abnormal craniofacial movements that produce involuntary eyelid twitching and closure. The efficacy and safety of botulinum toxin type A (BoNT-A) injections have been accepted and widely used for the treatment of HFS and BEB. However, different injection sites may influence the effectiveness, doses, and side effects. The aim of this study is to compare the efficacy, patient satisfaction, and complications of low-dose BoNT-A injections between injection at the preseptal (PS) and the pretarsal (PT) portion of the orbicularis oculi muscle...
September 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28863116/an-aesthetic-orbicularis-oculi-myectomy-technique-for-blepharospasm-use-of-topical-5-fluorouracil-and-fibrin-sealant
#5
Krista J Stewart, Shannon S Joseph, Raymond S Douglas
PURPOSE: To describe a modified technique of orbicularis oculi myectomy for refractory blepharospasm. This technique includes removal of orbicularis muscle, reformation of the eyelid crease and pretarsal platform using fibrin sealant (Tisseel), and topical 5-fluorouracil to reduce scar formation and improve aesthetic outcome. METHODS: Retrospective chart review of 7 patients who underwent bilateral orbicularis oculi myectomy with our technique from 2013 to 2016...
August 24, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28829782/exploratory-structural-assessment-in-craniocervical-dystonia-global-and-differential-analyses
#6
Larissa Vilany, Thiago J R de Rezende, Luiza G Piovesana, Lidiane S Campos, Paula C de Azevedo, Fabio R Torres, Marcondes C França, Augusto C Amato-Filho, Iscia Lopes-Cendes, Fernando Cendes, Anelyssa D'Abreu
INTRODUCTION: Our goal was to investigate the cortical thickness and subcortical volume in subjects with craniocervical dystonia and its subgroups. METHODS: We studied 49 subjects, 17 with cervical dystonia, 18 with blepharospasm or oromandibular dystonia, and 79 healthy controls. We performed a whole group analysis, followed by a subgroup analysis. We used Freesurfer software to measure cortical thickness, subcortical volume and to perform a primary exploratory analysis in the craniocervical dystonia group, complemented by a region of interest analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28818530/recent-developments-in-clinical-trials-of-botulinum-neurotoxins
#7
Antoniangela Cocco, Alberto Albanese
Botulinum neurotoxins (BoNTs) are increasingly used in clinical practice for several indications. Following the pioneering years of discoveries, the recent years have witnessed an increase of new indications and new toxin brands. We review here the clinical trials on BoNTs performed since 2014 and put them into perspective. We also review the ongoing trials listed by the National Institutes of Health registry (Clinicaltrials.gov). The following indications are reviewed here: blepharospasm, cervical dystonia, spasticity, cerebral palsy, urinary incontinence, headache, topical formulations, postoperative cardiac arrhythmia, keloids and scars...
August 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28769865/eyelid-dysfunction-in-neurodegenerative-neurogenetic-and-neurometabolic-disease
#8
REVIEW
Ali G Hamedani, Daniel R Gold
Eye movement abnormalities are among the earliest clinical manifestations of inherited and acquired neurodegenerative diseases and play an integral role in their diagnosis. Eyelid movement is neuroanatomically linked to eye movement, and thus eyelid dysfunction can also be a distinguishing feature of neurodegenerative disease and complements eye movement abnormalities in helping us to understand their pathophysiology. In this review, we summarize the various eyelid abnormalities that can occur in neurodegenerative, neurogenetic, and neurometabolic diseases...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28761348/depression-in-blepharospasm-a-question-of-facial-feedback
#9
Janis Rebecca Bedarf, Sied Kebir, Joan Philipp Michelis, Bettina Wabbels, Sebastian Paus
Depression is the most important nonmotor symptom in blepharospasm (BL). As facial expression influences emotional perception, summarized as the facial feedback hypothesis, we investigated if patients report fewer depressive symptoms if injections of botulinum neurotoxin (BoNT) include the "grief muscles" of the glabellar region, compared to treatment of orbicularis oculi muscles alone. Ninety BL patients were included, half of whom had BoNT treatment including the frown lines. While treatment pattern did not predict depressive symptoms overall, subgroup analysis revealed that in male BL patients, BoNT injections into the frown lines were associated with remarkably less depressive symptoms...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28680527/management-of-essential-blepharospasm
#10
Eric Clayman, Kathryn S King, Michael A Harrington
No abstract text is available yet for this article.
2017: Eplasty
https://www.readbyqxmd.com/read/28638211/psychogenic-blepharospasm-a-diagnostic-dilemma
#11
Soumitra DAS, Roopchand Pandrantil Sreedharan, Prasanth Sudhakaran Remadevi, Cheruvallil Velayudhan Saji
Blepharospasm is an uncontrolled spasmodic contraction of the orbicularis muscles of the eye resulting in an abnormal tic or twitch of eyes. It usually lasts for seconds to minutes but in severe cases eyes may be closed for hours. It may be essentially benign or secondary due to a lesion in basal ganglia, pyramidal tract, and trauma, local pathology in the eyes or drug induced. Here we are presenting a case of psychogenic blepharospasm. A 65 year old woman presented with a history of episodic inability of opening her eyes for the past 6 months...
December 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28629634/-123-i-fp-cit-spect-imaging-in-blepharospasm
#12
M De Verdal, D Renard, L Collombier, G Castelnovo
INTRODUCTION: Blepharospasm is a focal dystonia characterized by involuntary cocontraction of the eyelid protractors, causing spasmodic closure of the eyelids. Apraxia of eyelid opening is caused by an inability to initiate lid opening without paralytic abnormality. Some studies suggest that patients with either pure blepharospasm or blepharospasm associated with apraxia of eyelid opening are more prone to developing Parkinson's disease. METHODS: In our study, (123)I-FP-CIT (DAT) SPECT was performed in 24 patients with either pure blepharospasm or blepharospasm associated with apraxia of eyelid opening and no signs of parkinsonism to identify dopaminergic dysfunction...
June 16, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28588873/a-72-year-old-with-eyelid-opening-apraxia-in-steele-richardson-olszewski-syndrome
#13
Ihtesham A Qureshi, Mohtashim A Qureshi, Alberto Maud
In our patient with Steele-Richardson-Olszewski syndrome presenting with apraxia of eyelid opening, there is a possibility to be readily confused with conditions presenting in similar pattern such as blepharospasm and eyelid ptosis. Therefore, it is essential to correlate the clinical findings with electromyographic recordings and dopamine transporter scan (DaT).
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28566174/role-of-the-other-babinski-sign-in-hyperkinetic-facial-disorders
#14
Sara Varanda, Sofia Rocha, Margarida Rodrigues, Álvaro Machado, Gisela Carneiro
BACKGROUND: The "other Babinski sign" consists in the co-contraction of the orbicularis and frontalis muscles, causing an eyebrow elevation during ipsilateral eye closure. It cannot be voluntarily reproduced. AIMS OF THE STUDY: To determine the utility of this sign in the differential diagnosis of hyperkinetic facial disorders. METHODS: The presence of the sign was assessed in consecutive patients with blepharospasm, primary hemifacial spasm or post-paralytic facial syndrome treated in a botulinum toxin outpatient clinic...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28540017/cluster-headache-associated-with-secondary-unilateral-blepharospasm-a-case-report-and-review-of-the-literature
#15
Abbas Bagheri, Minoo Mohammadi, Ghader Harooni, Keyvan Khosravifard, Mohadeseh Feizi, Shahin Yazdani
PURPOSE: Cluster headache is one of the most serious types of headache that is accompanied by autonomic parasympathetic symptoms. Its association with hemifacial spasm in the same side had been rarely reported. The aim of this report is describing a case with this association and treatment strategies. CASE REPORT: Here we report a 37-year-old female with cluster headache associated with secondary unilateral blepharospasm that was successfully treated with combination therapy including botulinum toxin injection...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28539879/multiple-neural-networks-malfunction-in-primary-blepharospasm-an-independent-components-analysis
#16
Xiao-Feng Huang, Meng-Ru Zhu, Ping Shan, Chen-Hui Pei, Zhan-Hua Liang, Hui-Ling Zhou, Ming-Fei Ni, Yan-Wei Miao, Guo-Qing Xu, Bing-Wei Zhang, Ya-Yin Luo
Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Several neuroimaging studies have suggested dysfunction of sensory processing and sensorimotor integration, but the results have been inconsistent. This study aimed to determine whether patients with BPS exhibit altered functional brain connectivity and to explore possible correlations between these networks and clinical variables. Twenty-five patients with BPS and 25 healthy controls were enrolled...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28508467/keratitis-due-to-microfilariae-in-dogs-a-newly-recognized-disease
#17
Adriana Morales, Eduardo Perlmann, Aline Nayara Vechiato Abelha, Carlos Emilio Levy, Ana Carolina Almeida de Goes, Angélica M V Safatle
Parasitic agents have been associated with keratitis, but a diagnosis of parasitic keratitis has not been commonly made in domestic animals. The purpose of this study was to describe the clinical and histopathological findings in seven dogs with chronic keratitis caused by microfilariae diagnosed in Brazil. All dogs presented with superficial corneal opacities of varying degrees affecting the perilimbal and central regions of the cornea, with other opaque areas appearing as crystalline deposits and corneal vascularization...
May 15, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28488615/sensory-tricks-in-primary-blepharospasm-and-idiopathic-cervical-dystonia
#18
Sanjay Pandey, Gulab Soni, Neelav Sarma
OBJECTIVE: To study the frequency, types, phenomenology, and effectiveness of sensory tricks in patients with primary blepharospasm and idiopathic cervical dystonia. BACKGROUND: Sensory tricks are maneuvers seen in patients with dystonia, which are used to temporarily reduce the severity of dystonic postures. In different types of dystonia, the frequency of sensory tricks have been described to range from 17-89%. MATERIALS AND METHODS: In this cross-sectional observational study, we analyzed the frequency, types, phenomenology, and effectiveness of sensory tricks in 20 patients with primary blepharospasm and 20 patients with idiopathic cervical dystonia, respectively...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28476326/clinical-heterogeneity-in-patients-with-idiopathic-blepharospasm-a-cluster-analysis
#19
G Defazio, A Conte, A F Gigante, G Ferrazzano, R Pellicciari, S Dagostino, G Fabbrini, A Berardelli
BACKGROUND: Idiopathic blepharospasm is a clinically heterogeneous condition. It is not known whether the various manifestations become manifest sequentially during the course of the disease or aggregate in separate clusters identifying subpopulations of patients. METHODS: Eighty-nine patients with idiopathic blepharospasm were assessed using k-means cluster analysis to identify relatively homogeneous groups on the basis of low-intragroup/high-intergroup differences across a set of selected variables...
April 25, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28444838/modified-brow-suspension-technique-for-the-treatment-of-pseudoptosis-due-to-redundant-frontal-skin-in-the-dog-a-retrospective-study-of-25-cases
#20
Martí Cairó, Marta Leiva, Daniel Costa, Maria Teresa Peña
PURPOSE: To describe the outcome of modified brow suspension technique for the treatment of upper eyelid pseudoptosis in canine patients with redundant frontal skin folds. METHODS: Medical records from 1999 to 2015 were retrospectively reviewed. Only dogs that underwent modified brow suspension for treating bilateral pseudoptosis were included in the study. Recorded data included breed, age, gender, main ophthalmic complaint, ocular findings, suture material used for brow suspension, number of slings placed, postoperative treatment, complications, follow-up time, and outcome...
April 25, 2017: Veterinary Ophthalmology
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