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https://www.readbyqxmd.com/read/27909086/the-12-item-psoriatic-arthritis-impact-of-disease-questionnaire-construct-validity-reliability-and-interpretability-in-a-clinical-setting
#1
Marco Di Carlo, Andrea Becciolini, Valentina Lato, Chiara Crotti, Ennio Giulio Favalli, Fausto Salaffi
OBJECTIVE: To study, in a real-life setting, the construct validity, the reliability, and the interpretability of the 12-item Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire in patients with psoriatic arthritis (PsA). METHODS: In 144 consecutive patients with PsA (81 men and 63 women, mean age of 51.4 ± 12.8 yrs, and 77 receiving biologic treatment), the PsAID-12 and other patient-reported outcomes (PRO) were collected, such as the Dermatology Life Quality Index...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27867739/dermoscopic-hemorrhagic-dots-an-early-predictor-of-response-of-psoriasis-to-biologic-agents
#2
Aimilios Lallas, Giuseppe Argenziano, Iris Zalaudek, Zoe Apalla, Marco Ardigo, Patricia Chellini, Natalia Cordeiro, Mariana Guimaraes, Athanassios Kyrgidis, Elizabeth Lazaridou, Caterina Longo, Elvira Moscarella, Ilias Papadimitriou, Giovanni Pellacani, Elena Sotiriou, Efstratios Vakirlis, Dimitrios Ioannides
BACKGROUND: Biologic agents are routinely used in the treatment of severe psoriasis. The evaluation of treatment response is mainly based on the physician's global clinical assessment. OBJECTIVE: To investigate whether dermoscopy might enhance the assessment of response of psoriasis to treatment with biologic agents. METHODS: Patients with severe psoriasis scheduled to receive a biologic agent were enrolled in the study. A target lesion from each patient was clinically and dermoscopically documented at baseline and after one, two and six months...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27796896/the-cutaneous-telocytes
#3
Catalin G Manole, Olga Simionescu
Telocytes (TCs) are interstitial cells found in stroma of many organs, including the skin dermis. Ultrastructurally, normal skin TCs recapitulates all the previously documented features in interstitum of other organs. Their (ultra)structural hallmark is the presence of particular shaped cellular prolongations (termed telopodes), along other features as cellular organelles representation and their distribution within cell body and its prolongations. Transmission electron microscopy (TEM) or high magnification light microscopy indicated that the particular shape of telopodes alternate characteristically thin segments (termed podomeres) and dilated segments (called podoms)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27783331/psoriasiform-eruption-and-worsening-of-pustulosis-palmoplantaris-after-treatment-with-two-anti-tnf-%C3%AE-inhibitors-followed-by-successful-treatment-with-ustekinumab
#4
Nathalie A Bogaards, Menno A de Rie
INTRODUCTION: Tumor necrosis factor (TNF)-α inhibitors are widely used for the treatment of inflammatory diseases. One of the side effects of TNF-inhibitors is the development of a psoriatiform eruption, also known as paradoxical psoriasis. In this case report, we describe a patient with this side effect after treatment with adalimumab and etanercept. CASE REPORT: A 45-year-old female was treated with adalimumab 40 mg once every 2 weeks for pustulosis palmoplantaris and psoriatic arthritis...
October 25, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27748257/remission-of-psoriasis-after-autologous-stem-cell-transplantation-until-when
#5
Alexandra Azevedo, Cristina Gonçalves, Manuela Selores, Tiago Torres
No abstract text is available yet for this article.
October 17, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27747909/six-years-experience-of-grenz-ray-therapy-for-the-treatment-of-inflammatory-skin-conditions
#6
L Fenton, R S Dawe
BACKGROUND: In 2008, Ninewells Hospital became the first centre in the UK to offer grenz rays as a treatment for inflammatory dermatoses. Since then, 122 courses have been administered for the following conditions; scalp psoriasis (n = 36), nail dystrophies (n = 27), hyperkeratotic eczema/psoriasis (n = 22), palmoplantar pustulosis (n = 9), perianal pruritus (n = 9), warts (n = 4) and other conditions (n = 15). AIM: To review all patients who received grenz rays in order to determine which conditions have been treated successfully and to estimate remission times...
October 16, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27741127/anti-tnf%C3%AE-therapy-for-chronic-inflammatory-disease-in-kidney-transplant-recipients-clinical-outcomes
#7
Cyril Garrouste, Dany Anglicheau, Nassim Kamar, Claire Bachelier, Joseph Rivalan, Bruno Pereira, Sophie Caillard, Julien Aniort, Philippe Gatault, Martin Soubrier, Johnny Sayegh, Charlotte Colosio, Anthony Buisson, Eric Thervet, Nicolas Bouvier, Anne Elisabeth Heng
Anti-tumor necrosis factor-α (TNFα) therapy has improved the prognosis of many chronic inflammatory diseases. It appears to be well-tolerated by liver-transplant patients. However, their use and their safety in kidney-transplant patients have yet to be determined.In this retrospective study, we identified 16 adult kidney-transplant patients aged 46.5 years (34-51.8) who received anti-TNFα therapy from 7 kidney transplantation centers. The indications for this treatment included: chronic inflammatory bowel disease (n = 8), inflammatory arthritis (n = 5), AA amyloidosis (n = 1), psoriasis (n = 1), and microscopic polyangiitis (n = 1)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27726163/efficacy-and-safety-of-ixekizumab-treatment-for-japanese-patients-with-moderate-to-severe-plaque-psoriasis-erythrodermic-psoriasis-and-generalized-pustular-psoriasis-results-from-a-52-week-open-label-phase-3-study-uncover-j
#8
Hidehisa Saeki, Hidemi Nakagawa, Ko Nakajo, Taeko Ishii, Yoji Morisaki, Takehiro Aoki, Gregory S Cameron, Olawale O Osuntokun
Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Ixekizumab was administrated s.c. at baseline (week 0, 160 mg), from weeks 2 to 12 (80 mg every 2 weeks), and from weeks 16 to 52 (80 mg every 4 weeks)...
October 11, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27680219/a-randomised-half-body-prospective-study-of-low-and-medium-dose-regimens-using-the-308%C3%A2-nm-excimer-laser-in-the-treatment-of-localised-psoriasis
#9
Eleanor Higgins, Nicola Ralph, Sheila Ryan, Nicola Koik, Bahman Honari, Aoife Lally, Paul Collins
This study compared two dose-escalation regimens using the 308 nm excimer laser treating localised plaque psoriasis, to determine the optimal regimen. A randomised, left-right body trial was designed including patients aged >18 years with localised plaque psoriasis (<10% body surface area). The standard/low dose regimen started at 70% of the minimal erythema dose (MED), with 20% dose increments. The medium dose regimen commenced at 200% MED, with 25% increments. Patients were treated until disease clearance or a maximum of 36 treatments...
September 29, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27663917/treatment-options-for-pediatric-psoriasis
#10
REVIEW
Dora Madiraca, Mirna Šitum, Ivana Prkačin, Suzana Ožanić Bulić
Psoriasis is a multifactorial inflammatory papulosquamous disease affecting 0.5% to 2% of the pediatric population. Pediatric psoriasis, presenting similar to adult psoriasis, significantly reduces patient quality of life, often requiring an individualized treatment approach for each patient. Combination and rotational therapy are helpful in reducing toxicity and maximizing efficacy. Patients with mild and limited disease severity respond well to topical treatment with steroids or vitamin D analogues, unlike moderate and severe psoriasis where sufficient remission is rarely achieved...
August 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27650749/image-gallery-complete-remission-of-aggressive-desmoid-type-fibromatosis-after-low-dose-methotrexate-for-2%C3%A2-weeks-in-a-child-with-psoriasis
#11
S Simonsen, A Vera Casaño, E Gómez Moyano, A Sanz Trelles, C Bravo Bravo, L Martínez Pilar
No abstract text is available yet for this article.
October 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27617715/impact-of-psoriasis-flare-and-remission-on-quality-of-life-and-work-productivity-a-real-world-study-in-the-usa
#12
N J Korman, Y Zhao, J Roberts, J Pike, E Sullivan, Y Tsang, T Karagiannis
Although psoriasis patients often report a negative impact on health-related quality of life (HRQoL) and work productivity, less is known about how disease burden varies between periods of flare and remission. The aim of this study was tocompare HRQoL and work productivity by disease activity level. Data were extracted from Adelphi 2011/2013 Disease Specific Programmes, two real world surveys of US dermatologists and psoriasis patients. HRQoL was measured using the EuroQOL 5-Dimension Health Questionnaire (EQ-5D) and Dermatology Life Quality Index (DLQI)...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27607572/a-national-survey-on-the-management-of-psoriatic-arthritis-using-the-delphi-method
#13
Ennio Lubrano, Fabrizio Cantini, Alessandro Mathieu, Ignazio Olivieri, Carlo Salvarani, Raffaele Scarpa, Antonio Marchesoni
OBJECTIVES: Accurate diagnosis and appropriate management of psoriatic arthritis (PsA) is essential to avoid unnecessary morbidity. Our aim in this study was to evaluate the current approach to the management of PsA among rheumatologists. METHODS: A 16-item online questionnaire, produced using the Delphi method, was submitted to a panel of rheumatologists who anonymously expressed their opinions on a scale from 1 (maximum disagreement) to 5 (maximum agreement). Positive consensus was defined by ≥66% of the respondents scoring an item 3, 4 or 5...
August 31, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27579734/geographic-tongue-and-psoriasis-clinical-histopathological-immunohistochemical-and-genetic-correlation-a-literature-review
#14
Bruna Lavinas Sayed Picciani, Tábata Alves Domingos, Thays Teixeira-Souza, Vanessa de Carla Batista Dos Santos, Heron Fernando de Sousa Gonzaga, Juliana Cardoso-Oliveira, Alexandre Carlos Gripp, Eliane Pedra Dias, Sueli Carneiro
Geographic tongue is a chronic, inflammatory, and immune-mediated oral lesion of unknown etiology. It is characterized by serpiginous white areas around the atrophic mucosa, which alternation between activity, remission and reactivation at various locations gave the names benign migratory glossitis and wandering rash of the tongue. Psoriasis is a chronic inflammatory disease with frequent cutaneous involvement and an immunogenetic basis of great importance in clinical practice. The association between geographic tongue and psoriasis has been demonstrated in various studies, based on observation of its fundamental lesions, microscopic similarity between the two conditions and the presence of a common genetic marker, human leukocyte antigen (HLA) HLA-C*06...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27578078/itch-in-psoriasis-management
#15
Jacek C Szepietowski, Adam Reich
Psoriasis is a common chronic inflammatory skin disease observed in about 1-3% of the general population. About 60-90% of patients with psoriasis suffer from itching. Interestingly, in the past itch was not considered as an important symptom of psoriasis. Despite the high frequency of itch in psoriasis, the pathogenesis of this symptom is still not fully elucidated. Although most studies indicate neurogenic inflammation and the role of neuropeptides, other mediators may be important as well. The majority of psoriatic patients consider itch as the most bothersome symptom of the disease as it significantly alters daily functioning and psychosocial well-being...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27566090/remission-of-psoriasis-in-a-patient-with-hepatocellular-carcinoma-treated-with-sorafenib
#16
Efstathios A Antoniou, Ioannis Koutsounas, Christos Damaskos, Sotiris Koutsounas
BACKGROUND: Psoriasis is a chronic, immune-mediated and angiogenesis-dependent disease. Activated keratinocytes in psoriatic lesions produce pro-angiogenic cytokines, including vascular endothelial growth factor (VEGF), which binds to vascular endothelial growth factor receptor (VEGFR) and promotes cell proliferation and angiogenesis. Sorafenib (BAY 43-9006) is a molecular multikinase inhibitor of RAF kinase, platelet-derived growth factor (PDGF), VEGFR-1, -2, -3, platelet-derived growth factor receptor (PDGFR)-β and c-Kit...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27558077/increased-healthcare-resource-utilization-in-higher-disease-activity-levels-in-initiators-of-tnf-inhibitors-among-us-rheumatoid-arthritis-patients
#17
Natalie Boytsov, Leslie R Harrold, Marc A Mason, Carol L Gaich, Xiang Zhang, Cynthia J Larmore, Sabrina Rebello, Andre B Araujo
OBJECTIVE: Determine healthcare resource utilization (HCRU) in biologic-naïve initiators of TNF inhibitors (TNFis) associated with their disease activity from a national cohort of rheumatoid arthritis (RA) patients. METHODS: RA patients were identified at their first TNFi initiation (index date) in the Corrona registry. Patients with age of RA onset <18, comorbid psoriasis/psoriatic arthritis, fibromyalgia, or osteoarthritis were excluded. Patients were categorized into disease activity (DA) strata by the lowest level of DA (and sustaining low levels for at least two visits) using the Clinical Disease Activity Index (CDAI) across all visits in Corrona while on a TNFi during 1 year after initiation...
August 25, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27550839/resolution-of-inverse-psoriasis-after-treatment-with-levodopa-for-parkinson-s-disease
#18
Natalia Rojo Suárez, David Jiménez Gallo, Cintia Arjona Aguilera, Raúl Espinosa Rosso, Mario Linares Barrios
Inverse psoriasis is characterized by the development of erythematous shiny plaques at intertriginous areas of the body. It has a prevalence of 2% worldwide. The usefulness of levodopa in psoriasis was discovered in 1970 but nowadays it is not a standard therapy for this condition. A 74-year-old woman was diagnosed with Parkinson's disease subsequent to the development of extensive inverse psoriasis. The skin lesions were resistant to classical topical and systemic medications. Treatment with levodopa was initiated in order to treat her neurological problem and progressive remission of the skin lesions was noted...
August 23, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27535005/increased-expression-of-microrna-155-in-peripheral-blood-mononuclear-cells-from-psoriasis-patients-is-related-to-disease-activity
#19
S García-Rodríguez, S Arias-Santiago, G Blasco-Morente, J Orgaz-Molina, A Rosal-Vela, P Navarro, C Magro-Checa, A Martínez-López, J-C Ruiz, E Raya, R Naranjo-Sintes, J Sancho, M Zubiaur
BACKGROUND: MicroRNAs (miRNAs) gene expression regulators are altered in psoriasis suggesting their role in the pathogenesis. OBJECTIVE: To study expression changes of inflammation and toll-like receptor (TLR)-related miRNAs, miRNA-155, let-7i, miRNA-21, miRNA-146a and miRNA-223 in peripheral mononuclear cells (PBMCs) and miRNA-21, miRNA-146a and miRNA-223 in plasma, from chronic plaque-type psoriasis patients who were treatment-naive or had undergone a washout period (n = 11)...
August 17, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27516685/psoriasis-and-topical-iranian-traditional-medicine
#20
Akramosadat Atyabi, Laila Shirbeigi, Fateme Eghbalian
BACKGROUND: Psoriasis is a common chronic inflammatory skin, nails, and joints disease related to the immune system by periods of exacerbations and remissions. It is characterized by thick end, erythematous, and scaling lesions, which affects about 2 to 4 percent of the general population. The disease occurs equally in both sexes and the most common form of the disease is psoriasis vulgaris. The etiology is unknown but genetic and environmental factors, immune system disorders, and gastrointestinal dysfunction appear to be responsible...
May 2016: Iranian Journal of Medical Sciences
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