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https://www.readbyqxmd.com/read/29575224/oral-psoriasis-and-sibo-is-there-a-link
#1
Francesco Drago, Giulia Ciccarese, Vittorio Cordara, Michele Paudice, Astrid Herzum, Aurora Parodi
Oral manifestations of psoriasis are found in about 2% of psoriatic patients but they are probably underestimated because they can be nonspecific and mucosal biopsy is rarely done. Geographic tongue (GT) is the most frequent oral lesion associated with psoriasis: it consists of erythematous patches surrounded by white/yellow serpiginous borders, with possible spontaneous remission/reactivation and burning sensation1,2 . Fissured tongue (FT) is often associated with GT and both may be found in healthy subjects1-3 ...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29566966/considerations-for-the-definition-of-remission-criteria-in-psoriatic-arthritis
#2
REVIEW
Philip J Mease, Laura C Coates
OBJECTIVES: Psoriatic arthritis (PsA) is an autoimmune disease that can cause progressive structural damage of the joints and irreversible disability. The potentially achievable results of biologic therapy for PsA has led to the view that disease remission should be the goal of treatment. However, the heterogeneity of disease manifestations and need for validated outcome measures makes defining remission in PsA challenging. This article evaluates proposed criteria for defining remission in PsA and discusses how these criteria can be applied in clinical practice...
October 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29556416/4-year-results-from-the-rapid-psa-phase-3-randomised-placebo-controlled-trial-of-certolizumab-pegol-in-psoriatic-arthritis
#3
Désirée van der Heijde, Atul Deodhar, Oliver FitzGerald, Roy Fleischmann, Dafna Gladman, Alice B Gottlieb, Bengt Hoepken, Lars Bauer, Oscar Irvin-Sellers, Majed Khraishi, Luke Peterson, Anthony Turkiewicz, Jürgen Wollenhaupt, Philip J Mease
Objective: To report the efficacy, patient-reported, radiographic and safety outcomes of 4 years' certolizumab pegol (CZP) treatment in patients with psoriatic arthritis (PsA). Methods: RAPID-PsA (NCT01087788) was double-blind and placebo-controlled to Week 24, dose-blind to Week 48 and open-label (OL) to Week 216. Patients were randomised 1:1:1 to either placebo or CZP 200 mg every 2 weeks (Q2W) or 400 mg every 4 weeks (Q4W) (following 400 mg at Weeks 0/2/4)...
2018: RMD Open
https://www.readbyqxmd.com/read/29536977/intramatricial-injections-for-nail-psoriasis-an-open-label-comparative-study-of-triamcinolone-methotrexate-and-cyclosporine
#4
Jyotisterna Mittal, Bharat Bhushan Mahajan
BACKGROUND: One of the most effective options available for treating psoriatic fingernails is intramatricial injection of triamcinolone acetonide. Efficacies of intramatricial methotrexate and cyclosporine have not been comparatively evaluated to date. METHODS: Ninety fingernails in 17 patients were assigned to three groups of thirty nails each, and treated with intramatricial injections of triamcinolone acetonide (10 mg/ml), methotrexate (25 mg/ml) and cyclosporine (50 mg/ml) respectively...
March 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29536565/chronic-cutaneous-graft-versus-host-disease-in-children-a-report-of-14-patients-from-a-tertiary-care-pediatric-dermatology-clinic
#5
Arti Nanda, Maitham A A Husain, Waleed Al-Herz, Adla Almekaimi, Humoud Al-Sabah, Mohammad Al-Otaibi
BACKGROUND/OBJECTIVES: Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment option for many life-threatening disorders in children. Chronic graft-versus-host disease (cGVHD) is a significant complication of HSCT, and its treatment is challenging. Skin is the most common organ affected in cGVHD, with protean manifestations posing a challenge in diagnosis and management. The objective was to have a better understanding of the spectrum of chronic cutaneous GVHD (cc-GVHD) in children...
March 14, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29529118/complete-remission-of-metastatic-merkel-cell-carcinoma-in-a-patient-with-severe-psoriasis
#6
James Yousif, Brandon Yousif, Mark A Kuriata
No abstract text is available yet for this article.
January 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29511028/-deep-koebner-phenomenon-of-the-flexor-tendon-associated-accessory-pulleys-as-a-novel-factor-in-tenosynovitis-and-dactylitis-in-psoriatic-arthritis
#7
Ilaria Tinazzi, Dennis McGonagle, Sibel Zehra Aydin, Donatella Chessa, Antonio Marchetta, Pierluigi Macchioni
OBJECTIVES: Skin and joint involvement in psoriasis (PsO) and psoriatic arthritis (PsA) are thought to relate to the so-called Koebner response. Given that dactylitis is non-randomly distributed in the digits, this study tested the hypothesis that the accessory pulleys linked to the flexor tendons were thickened in PsA and thus exhibited koebnerisation. METHODS: Ninety-six subjects (27 PsA, 27 rheumatoid arthritis (RA), 23 PsO and 19 healthy controls (HCs)) were enrolled...
March 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29489039/exploring-the-in-situ-expression-of-vascular-endothelial-growth-factor-and-endoglin-in-pemphigus-foliaceus-variants-and-pemphigus-vulgaris
#8
D Miyamoto, C W Maruta, C G Santi, P Zoroquiain, A B T Dias, J J Mansure, M N Burnier, V Aoki
BACKGROUND: Erythroderma is a severe manifestation of pemphigus foliaceus (PF), a blistering disease mediated by IgG autoantibodies against desmoglein-1. Increasing evidence supports the contribution of angiogenic mediators in the pathogenesis of erythroderma. OBJECTIVE: To evaluate the in situ expression of vascular endothelial growth factor (VEGF) and endoglin in PF patients with erythroderma. METHODS: Formalin-fixed paraffin-embedded skin samples obtained from patients with erythrodermic PF (n=19; 12 patients with endemic PF), non-erythrodermic PF (n=17), pemphigus vulgaris (PV; n=10), psoriasis (n=10), and healthy individuals (HI; n=10) were processed in an automated immunohistochemistry platform utilizing anti-VEGF and anti-endoglin as primary antibodies...
February 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29469754/clinical-improvement-of-a-patient-with-both-amyopathic-dermatomyositis-and-psoriasis-following-treatment-with-cyclosporine
#9
Megan S Inkeles, Daniel No, Jashin J Wu
Clinically amyopathic dermatomyositis (CADM) is an uncommon subtype of dermatomyositis that rarely presents simultaneously with psoriasis. There are subsequently few reports discussing the management of concurrent CADM and psoriasis. Furthermore, skin lesions of CADM are often recalcitrant to first line dermatomyositis interventions. We present a case of a 45-year-old woman with both CADM and psoriasis whose lesions were resistant to multiple therapies; she eventually achieved disease control and remission with cyclosporine...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469706/alopecia-universalis-unresponsive-to-treatment-with-tofacinitib-report-of-a-case-with-a-brief-review-of-the-literature
#10
Andac Salman, Gonca Sarac, Tulin Ergun
Janus kinase inhibitors are emerging treatment alternatives in various immune-mediated diseases including alopecia universalis. Herein, we report a patient with psoriasis and alopecia universalis in whom treatment with tofacitinib led to remission of psoriasis without improvement in alopecia universalis. Despite the promising potential in alopecia areata treatment, research evaluating the efficacy of different Janus kinase inhibitors and possible prognostic factors related with a more favorable response are warranted...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29382023/case-report-remarkable-remission-of-sapho-syndrome-in-response-to-tripterygium-wilfordii-hook-f-treatment
#11
Chen Li, Xiaochuan Sun, Yihan Cao, Wenrui Xu, Wen Zhang, Zhenhua Dong
RATIONALE: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is an autoinflammatory disease with no standardized treatment. Tripterygium wilfordii hook f (TwHF) is a Chinese herb with immunosuppressive effects and has been used to treat some chronic inflammatory diseases. However, it has not been reported as a therapeutic option in SAPHO syndrome. Here we present the first report in which a remarkable remission of SAPHO syndrome was achieved in response to TwHF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29368846/cyclosporine-in-clinical-practice-a-retrospective-study-comparing-fixed-dose-and-body-weight-based-dose-regimens-in-psoriatic-patients
#12
Federico Bardazzi, Giulia Odorici, Michela Magnano, Annalisa Patrizi, Vera Tengattini
BACKGROUND: In the treatment of various diseases, such as diabetes and arterial hypertension, fixed dose therapies have been reported to offer a method to simplify complex treatment regimens. There are numerous clinical trials proving the efficacy of cyclosporine in psoriasis in inducing remission and maintaining results, although there are few studies about the treatment optimization of cyclosporine. METHODS: We performed a 15-year retrospective observational study comparing two groups of psoriatic patients matched for age and sex...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29335738/remission-of-psoriasis-after-treatment-of-chronic-hepatitis-c-virus-infection-with-direct-acting-antivirals
#13
Masaru Enomoto, Chiharu Tateishi, Daisuke Tsuruta, Akihiro Tamori, Norifumi Kawada
No abstract text is available yet for this article.
January 16, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29330859/differential-effects-of-phototherapy-adalimumab-and-betamethasone-calcipotriol-on-effector-and-regulatory-t-cells-in-psoriasis
#14
I S Kotb, B J Lewis, R N Barker, A D Ormerod
BACKGROUND: Psoriasis is a chronic T cell-mediated skin disease with marked social and economic burdens. Current treatments are unsatisfactory, with unpredictable remission times and incompletely understood modes of action. Recent advances in our understanding of the pathogenesis of psoriasis identify the imbalance between CD4+ T effector cells, particularly the T helper (Th) 17 subset, and regulatory T cells (Treg) as key to the development of psoriatic lesions, and therefore a novel therapeutic target...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29274242/phosphorylation-of-intracellular-signaling-molecules-in-peripheral-blood-cells-from-psoriasis-patients-on-originator-or-biosimilar-infliximab
#15
A K Aarebrot, S M Solberg, R Davies, L I Bader, T D Holmes, S Gavasso, Y T Bryceson, R Jonsson, L F Sandvik, S Appel
BACKGROUND: Psoriasis vulgaris is a chronic, inflammatory skin disease characterized by a dysregulated immune response and it is associated with substantial systemic comorbidities. Biological drugs like tumor necrosis factor (TNF) inhibitors can ameliorate the disease but are expensive. Biosimilar drugs have the same amino acid sequence as the originator, but differences in manufacturing can affect biological activity, efficacy and tolerability. OBJECTIVES: We aimed to explore potential differences in intracellular phosphorylation of signaling molecules in peripheral blood cells from TNF inhibitor infliximab treated psoriasis patients compared to healthy controls, and to investigate if the phosphorylation pattern was influenced by switching from originator infliximab to biosimilar CT-P13...
December 23, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29259830/iatrogenic-cushing-s-syndrome-with-subsequent-adrenal-insufficiency-in-a-patient-with-psoriasis-vulgaris-using-topical-steroids
#16
Suzan Demir Pektas, Gursoy Dogan, Nese Cinar
Iatrogenic Cushing's syndrome (ICS) is usually related to prolonged and/or high-dose oral or parenteral steroid use. Psoriasis vulgaris (PV) is chronic inflammatory disease and characterized by periods of attack and remission. Topical steroid (TS) is the first choice of treatment for localized and mild PV. The development of systemic side effects of the steroids is usually not observed after TS application. But the risk of developing ICS still exists. In the literature, there are a few adult cases who developed ICS and subsequent adrenal insufficiency associated with TS...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29214695/psoriasis-improvement-after-gastric-bandage-in-a-patient-partial-responder-to-infliximab
#17
Giulia Odorici, Andrea Conti
Patients overweight or obese have more severe psoriasis than normal weight patients. Sometimes the excessive weight is related to a lack of efficacy of systemic treatment. We report a case of a psoriatic patient that experienced a dramatic improvement of psoriasis after weight loss surgery by gastric bandage. The great weight loss was accompanied by an effectiveness gain of response to infliximab. The mechanism responsible for this association is not certain, but it is probably multifactorial, involving genetic, environmental and immune-mediated factors...
December 7, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29196889/durable-resolution-of-severe-psoriasis-in-a-patient-treated-with-pentostatin-for-hairy-cell-leukemia-a-case-report
#18
Tamim Alsuliman, Kaiss Lassoued, Maifa Belghoul, Karima Debbache, Bachra Choufi
INTRODUCTION: Pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine) are adenosine analogues widely used to treat lymphoid malignancies, mainly hairy cell leukemia (HCL). Oral or parenteral adenosine analogues have been also used as immunomodulatory agents in multiple sclerosis and in acute graft-versus-host disease. CASE REPORT: Here, we report the case of a 43-year-old patient with a history of extensive psoriasis who later developed HCL. RESULTS: The patient had achieved complete remission of both psoriasis and HCL after receiving intravenous infusions of pentostatin...
March 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29142032/minimal-disease-activity-as-a-treatment-target-in-psoriatic-arthritis-a-review-of-the-literature
#19
REVIEW
Laure Gossec, Dennis McGonagle, Tatiana Korotaeva, Ennio Lubrano, Eugenio de Miguel, Mikkel Østergaard, Frank Behrens
As in other inflammatory rheumatic diseases, the objective of psoriatic arthritis (PsA) treatment is the achievement of a defined target. Recent recommendations propose aiming for remission or low disease activity; however, a consensual definition of remission is lacking. A state of minimal disease activity (MDA) has been established and is defined by low activity assessed by tender/swollen joint counts, tender entheseal points, Psoriasis Area and Severity Index or body surface area, patient pain and global activity visual analog scale, and functional evaluation by Health Assessment Questionnaire...
January 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29080861/ideal-target-for-psoriatic-arthritis-comparison-of-remission-and-low-disease-activity-states-in-a-real-life-cohort
#20
Leonieke J J van Mens, Marleen G H van de Sande, Arno W R van Kuijk, Dominique Baeten, Laura C Coates
BACKGROUND: Psoriatic arthritis (PsA) recommendations state that the target of treatment should be remission or low disease activity (LDA). We used a real-life dataset to compare different potential targets. METHODS: 250 patients with PsA considered in an acceptable disease state according to their rheumatologist were included. Targets for remission were the Disease Activity Index for Psoriatic Arthritis (DAPSA) and clinical DAPSA (cDAPSA) remission (≤4), very low disease activity (VLDA) and Psoriatic Arthritis Disease Activity Score ≤1...
February 2018: Annals of the Rheumatic Diseases
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