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https://www.readbyqxmd.com/read/29457310/natural-fruits-flowers-honey-and-honeybees-harbor-helicobacter-pylori-positive-yeasts
#1
Farideh Siavoshi, Marzieh Sahraee, Hoda Ebrahimi, Abdolfatah Sarrafnejad, Parastoo Saniee
BACKGROUND: For controlling Helicobacter pylori infection in humans, its environmental reservoir should be determined. In this study, yeast isolates from an isolated village in Iran were studied for the intracellular occurrence of H. pylori. MATERIALS AND METHODS: In this study, yeasts were isolated from 29 samples, including oral swabs from villagers (n = 7), flowers and fruits (n = 6), honey and honeybees (n = 12) and miscellaneous samples (4). Yeasts were classified into 12 RFLP groups and identified by amplification of 26S rDNA and sequencing...
February 19, 2018: Helicobacter
https://www.readbyqxmd.com/read/29456644/eudesmin-attenuates-helicobacter-pylori-induced-epithelial-autophagy-and-apoptosis-and-leads-to-eradication-of-h-pylori-infection
#2
Jai-Sing Yang, Chao-Min Wang, Chiu-Hsian Su, Han-Chen Ho, Chiung-Hung Chang, Chang-Hung Chou, Yuan-Man Hsu
Eudesmin has been proven to possess anti-inflammatory effects. In the present study, the effects of eudesmin on Helicobacter pylori (H. pylori) -mediated autophagy, apoptosis, immune response and inflammation were determined in human gastric adenocarcinoma (AGS) cells in vitro and in C57BL/6 mice in vivo . Detection of the production of interleukin (IL)-8, IL-1β and immunoglobulin M (IgM) was performed using ELISA. Identification of the activation of apoptosis-associated caspase-3, -8 and -9 proteins, Bcl-2-associated X protein (Bax) and BH3 interacting domain death agonist (Bid) protein, was determined through western blot analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456060/association-of-tnf-%C3%AE-but-not-il-1%C3%AE-levels-with-the-presence-of-helicobacter-pylori-infection-increased-the-risk-of-peptic-ulcer-development
#3
Mehdi Tourani, Maryam Habibzadeh, Ahmad Karkhah, Javad Shokri-Shirvani, Ladan Barari, Hamid Reza Nouri
Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. With regard to the significance of these cytokines in peptic ulcer development and the high prevalence of this disease in the developing countries, this study aimed to investigate the association of TNF-α and IL-1β with peptic ulcer in the presence of H...
February 15, 2018: Cytokine
https://www.readbyqxmd.com/read/29452847/primary-antibiotic-resistance-and-its-relationship-with-caga-and-vaca-genes-in-helicobacter-pylori-isolates-from-algerian-patients
#4
Meryem Bachir, Rachida Allem, Abedelkarim Tifrit, Meriem Medjekane, Amine El-Mokhtar Drici, Mustafa Diaf, Kara Turki Douidi
The epidemiology of Helicobacter pylori resistance to antibiotics is poorly documented in Africa and especially in Algeria. The aim of our study was to determine the antibiotic resistance rates, as well as its possible relationship with VacA and CagA virulence markers of isolates from Algerian patients. One hundred and fifty one H. pylori isolate were obtained between 2012 and 2015 from 200 patients with upper abdominal pain. Antimicrobial susceptibility testing was performed for amoxicillin, clarithromycin, metronidazole, ciprofloxacin, rifampicin and tetracycline...
February 13, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29452574/association-of-helicobacter-pylori-and-protozoal-parasites-in-patients-with-chronic-diarrhoea
#5
J Yakoob, Z Abbas, R Khan, K Tariq, S Awan, M A Beg
Introduction An association of Helicobacter pylori and common protozoal parasites in patients with abdominal discomfort and chronic diarrhoea is unclear and may be pathological. Materials and methods One hundred and sixty-one patients with diarrhoea were compared to 114 age and sex matched controls. Stool samples were examined by microscopy and DNA extracted for PCR with specific primers for H. pylori and protozoal parasites Blastocystis sp., Entamoeba sp. (Entamoeba histolytica, Entamoeba dispar and Entamoeba moshkovskii) and Giardia duodenalis (G...
February 16, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29452293/genetic-diversity-and-functional-analysis-of-oipa-gene-in-association-with-other-virulence-factors-among-helicobacter-pylori-isolates-from-iranian-patients-with-different-gastric-diseases
#6
Nastaran Farzi, Abbas Yadegar, Hamid Asadzadeh Aghdaei, Yoshio Yamaoka, Mohammad Reza Zali
Helicobacter pylori (H. pylori) is one of the most genetically diverse bacterial pathogens that persistently colonizes the human gastric epithelium. This remarkable genomic plasticity may act as a driving force for successful adaptation and persistence of the bacteria in the harsh gastric environment. Outer inflammatory protein A (OipA) encoded by oipA gene (HP0638/hopH) is a member of the outer membrane proteins (OMPs) of H. pylori involved in induction of IL-8 secretion and is associated with development of peptic ulcer and gastric cancer...
February 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29452048/high-frequency-of-metronidazole-and-clarithromycin-resistant-helicobacter-pylori-in-formalin-fixed-paraffin-embedded-gastric-biopsies
#7
B Pourakbari, S Mahmoudi, J Parhiz, R H Sadeghi, M Monajemzadeh, S Mamishi
BACKGROUND: Clarithromycin and metronidazole resistance of Helicobacter pylori is increasing worldwide and has resulted in a loss in the effectiveness of therapeutic regimens. We aimed to evaluate common mutations of resistance genes to clarithromycin (A2143G, A2142G and A2142C) and metronidazole (rdxA and frxA) in H. pylori strains in formalin-fixed, paraffin-embedded gastric biopsies. METHODS: A total of 110 tissue blocks from children suspected of H. pylori infection were included...
February 16, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29449092/efficacy-of-narrow-band-imaging-for-detecting-intestinal-metaplasia-in-adult-patients-with-symptoms-of-dyspepsia
#8
S Sobrino-Cossío, J M Abdo Francis, F Emura, E S Galvis-García, M L Márquez Rocha, G Mateos-Pérez, C B González-Sánchez, N Uedo
INTRODUCTION AND OBJECTIVE: Atrophy and intestinal metaplasia are early phenotypic markers in gastric carcinogenesis. White light endoscopy does not allow direct biopsy of intestinal metaplasia due to a lack of contrast of the mucosa. Narrow-band imaging is known to enhance the visibility of intestinal metaplasia, to reduce sampling error, and to increase the diagnostic yield of endoscopy for intestinal metaplasia in Asian patients. The aim of our study was to validate the diagnostic performance of narrow-band imaging using 1...
February 12, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29448222/a-colorimetric-broth-microdilution-method-for-assessment-of-helicobacter-pylori-sensitivity-to-antimicrobial-agents
#9
Petar Knezevic, Verica Aleksic Sabo, Natasa Simin, Marija Lesjak, Neda Mimica-Dukic
Helicobacter pylori is a major infective etiological agent of the upper gastrointestinal tract diseases. The bacterium exhibits resistance to various conventional antibiotics, being usually challenging for eradication. Since there is an urge to consider alternative therapeutic strategies, the aim of the study was to examine selected essential oils of plants belonging to families Cupressaceae (Juniperus communis) and Lamiaceae (Hyssopus officinalis, Salvia officinalis, Melissa officinalis, Lavandula angustifolia, Ocimum basilicum and Thymus serpyllum) against H...
February 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29446491/characterization-of-morphological-conversions-of-helicobacter-pylori-under-anaerobic-conditions
#10
Sayaka Hirukawa, Hiroshi Sagara, Satoshi Kaneto, Tomoyo Kondo, Kotaro Kiga, Takahito Sanada, Hiroshi Kiyono, Hitomi Mimuro
Helicobacter pylori (H. pylori) is a Gram-negative microaerophilic bacterial pathogen which colonizes the stomach of more than half the human population, and is linked to chronic gastritis, peptic ulcers, and gastric cancer. Spiral-shaped H. pylori undergo morphologic conversion to the viable but not culturable (VBNC) coccoid form as they transit from the microaerobic stomach into the anaerobic intestinal tract. However, little is known about the morphological and pathogenic characteristics of H. pylori under prolonged anaerobic conditions...
February 15, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29445363/-helicobacter-pylori-infection-is-not-associated-with-non-alcoholic-fatty-liver-disease-a-cross-sectional-study-in-china
#11
Nengguang Fan, Liang Peng, Zhenhua Xia, Lijuan Zhang, Yufan Wang, Yongde Peng
Background and Aim: Helicobacter pylori infection has been reported to promote the development of a variety of extra-digestive manifestations, including type 2 diabetes, cardiovascular and liver diseases. Recently, the association between H. pylori infection and non-alcoholic fatty liver disease (NAFLD) was also proposed. However, evidence from different studies was controversial. We therefore performed this study to investigate the relationship between them in a large population of apparently healthy subjects in China...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29444465/simultaneous-detection-of-human-cyp2c19-polymorphisms-and-antibiotic-resistance-of-helicobacter-pylori-using-a-personalized-diagnosis-kit
#12
Jun Zhang, Jing Zhong, Jian Ding, Jiemin Shi, Tao Tang, Qiqi Liu, Huilian Huang, Licheng Dai, Ningmin Yang
OBJECTIVES: We evaluated a personalized diagnosis kit for Helicobacter pylori that employs visual gene chip technology for the simultaneous detection of CYP2C19 polymorphisms, and clarithromycin/levofloxacin antibiotic resistance. METHODS: H. pylori isolates from the gastric antrum mucosa of 394 patients were tested using the kit. DNA sequencing and antibiotic susceptibility testing were also performed. RESULTS: In total, 267/394 (67.77%) specimens were positive for H...
February 11, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29444284/gentamicin-intercalated-smectite-as-a-new-therapeutic-option-for-helicobacter-pylori-eradication
#13
Su Jin Jeong, Jie-Hyun Kim, Da Hyun Jung, Kyoung Hwa Lee, Soon Young Park, Yungoo Song, Il-Mo Kang, Young Goo Song
Objectives: Novel antibacterial strategies against Helicobacter pylori are needed because H. pylori strains are acquiring resistance to antibiotics. We evaluated the efficacy of gentamicin-intercalated smectite hybrid (S-GEN)-based treatment regimens in a murine model of H. pylori infection. Methods: Two groups of 10 rats were administered either smectite or S-GEN to measure coverage of the gastric mucosa. To evaluate anti-H. pylori efficacy, mice were divided into eight groups of 10 mice each given different treatments, and H...
February 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29442488/biological-properties-and-pathogenicity-factors-of-helicobacter-pylori
#14
Guzel S Isaeva, Sharmila Fagoonee
The unexpected discovery of Helicobacter pylori (H. pylori) has revolutionised the history of microbiology as well as of gastroenterology in the last 30 years, with an invaluable benefit for millions of persons worldwide. The confirmation that this Gram-negative spiral bacterium could live in the stomach has rendered out-of-date the concept of inhospitality of micro-organisms in the gastric environment, after a long history of unheard reports on the presence of spiral bacteria in the stomach. The pathogenicity of H...
February 14, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29442458/the-influence-of-vitamin-d-deficiency-on-eradication-rates-of-helicobacter-pylori
#15
Oguzhan Yildirim, Tulay Yildirim, Yuksel Seckin, Pelin Osanmaz, Yilmaz Bilgic, Rafet Mete
BACKGROUND: Helicobacter pylori eradication therapy improves the healing of various gastro-duodenal diseases such as chronic gastritis and peptic ulcer, and also reduces gastric cancer incidence. Several studies have reported on risk factors other than antibiotic resistance related to Helicobacter pylori eradication failure. OBJECTIVES: In this study, we aimed to investigate whether or not the serum levels of 25-hydroxy-vitamin D (25(OH)D) influence eradication rates of H...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29440770/anti-helicobacter-pylori-activities-of-selected-n-substituted-cinnamamide-derivatives-evaluated-on-reference-and-clinical-bacterial-strains
#16
Karolina Klesiewicz, Elżbieta Karczewska, Paweł Nowak, Iwona Skiba-Kurek, Edward Sito, Katarzyna Pańczyk, Paulina Koczurkiewicz, Dorota Żelaszczyk, Elżbieta Pękala, Anna M Waszkielewicz, Alicja Budak, Henryk Marona, Agnieszka Gunia-Krzyżak
In this study, thirty-five N-substituted derivatives of cinnamic acid amide (cinnamamide) were evaluated for anti-Helicobacter pylori activity using an agar disc-diffusion method. Qualitative screening was performed on a reference H. pylori strain (ATCC 43504), resulting in the identification of the three most active compounds, 8 (R,S-(2E)-3-(4-chlorophenyl)-N-(2-hydroxypropyl)prop-2-enamide, minimal inhibitory concentration, MIC = 7.5 µg/mL), 23 ((2E)-3-(4-chlorophenyl)-N-(2-hydroxycyclohexyl)prop-2-enamide, MIC = 10 µg/mL), and 28 ((2E)-3-(4-chlorophenyl)-N-(4-oxocyclohexyl)prop-2-enamide, MIC = 10 µg/mL)...
February 13, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29434449/impact-of-snp-snp-interactions-of-dna-repair-gene-ercc5-and-metabolic-gene-gstp1-on-gastric-cancer-atrophic-gastritis-risk-in-a-chinese-population
#17
Liang Sang, Zhi Lv, Li-Ping Sun, Qian Xu, Yuan Yuan
AIM: To investigate the interactions of the DNA repair gene excision repair cross complementing group 5 (ERCC5) and the metabolic gene glutathione S-transferase pi 1 (GSTP1) and their effects on atrophic gastritis (AG) and gastric cancer (GC) risk. METHODS: Seven ERCC5 single nucleotide polymorphisms (SNPs) (rs1047768, rs2094258, rs2228959, rs4150291, rs4150383, rs751402, and rs873601) and GSTP1 SNP rs1695 were detected using the Sequenom MassARRAY platform in 450 GC patients, 634 AG cases, and 621 healthy control subjects in a Chinese population...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29434176/associations-between-caga-vaca-and-the-clinical-outcomes-of-helicobacter-pylori-infections-in-okinawa-japan
#18
Tomoko Inagaki, Shin Nishiumi, Yoshiyuki Ito, Akiyo Yamakawa, Yukinao Yamazaki, Masaru Yoshida, Takeshi Azuma
Helicobacter pylori, which is involved in the pathogenesis of gastroduodenal disease, produces CagA and VacA as major virulence factors. CagA is classified into East Asian and Western types based on the number and sequences of its Glu-Pro-Ile-Tyr-Ala motifs. The vacA gene has three polymorphic regions: the signal (s), intermediate (i), and middle (m) regions. The lowest gastric cancer mortality rate is seen in Okinawa. On the Japanese mainland (Honshu), most H. pylori produce s1/m1-VacA, which exhibits strong toxicity, and East Asian-type CagA...
November 22, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29432909/influence-of-helicobacter-pylori-virulence-factors-caga-and-vaca-on-pathogenesis-of-gastrointestinal-disorders
#19
REVIEW
Shima Nejati, Ahmad Karkhah, Hossein Darvish, Majid Validi, Soheil Ebarhimpour, Hamid Reza Nouri
Helicobacter Pylori (H. pylori) is a gram-negative bacteria infecting numerous people all over the world. It has been established that H. pylori play an important role in pathogenesis of gastritis, peptic ulcer and gastric cancer. Pathogenic features of this bacterium are mainly attributes to the existence of pathogenic islands (PAI) genes. The most known genes in these islands are cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene (VacA). Most studies demonstrated various frequency of CagA and VacA in patient with peptic ulcer or gastritis in different countries...
February 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29430669/systematic-review-with-meta-analysis-the-worldwide-prevalence-of-helicobacter-pylori-infection
#20
REVIEW
M Zamani, F Ebrahimtabar, V Zamani, W H Miller, R Alizadeh-Navaei, J Shokri-Shirvani, M H Derakhshan
BACKGROUND: The epidemiology of Helicobacter pylori infection is poorly understood. AIM: To establish the reported regional and national prevalence of H. pylori infection, stratified by age and gender. METHODS: All relevant English publications from 2000 to 2017 cited by PubMed and Scopus were retrieved using comprehensive combinations of keywords. The overall prevalence of H. pylori was estimated using both random effect and fixed effect meta-analyses, and presented as prevalence rate (% and 95% CI)...
February 12, 2018: Alimentary Pharmacology & Therapeutics
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