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https://www.readbyqxmd.com/read/29243850/serum-pepsinogen-1-and-anti-helicobacter-pylori-igg-antibodies-as-predictors-of-gastric-cancer-risk-in-finnish-males
#1
M Song, M C Camargo, S J Weinstein, G Murphy, N D Freedman, J Koshiol, R Z Stolzenberg-Solomon, C C Abnet, S Männistö, D Albanes, C S Rabkin
BACKGROUND: Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM: To assess utility of these markers in a Western population. METHODS: SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. We used Cox proportional hazards models adjusted for potential confounders to estimate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI) for low SPG1 (<25 μg/L)...
December 15, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29243786/spectrum-of-gastric-histopathologies-in-morbidly-obese-turkish-patients-undergoing-laparoscopic-sleeve-gastrectomy
#2
U Dogan, D Suren, M T Oruc, A A Gokay, B Mayir, T Cakir, A Aslaner, O Z Oner, N Bulbuller
OBJECTIVE: In this study, we aimed to describe the findings associated with gastric pathology and to identify the prevalence of Helicobacter pylori (H. pylori) in patients undergoing laparoscopic sleeve gastrectomy (LSG). PATIENTS AND METHODS: Gastric specimens of a total of 291 patients (225 females, 66 males; mean age: 42 years; range: 18 to 60 years) who underwent LSG for the treatment of morbid obesity were analyzed. Histopathologic diagnoses and their relation with body mass index (BMI), age and gender were evaluated...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243018/decreased-microrna-mir-181c-expression-associated-with-gastric-cancer
#3
Luanna Munhoz Zabaglia, Nicole Chiuso Bartolomeu, Mônica Pezenatto Dos Santos, Rita Luiza Peruquetti, Elizabeth Chen, Marilia de Arruda Cardoso Smith, Spencer Luiz Marques Payão, Lucas Trevizani Rasmussen
PURPOSE: This study investigated miRNA-181c expression in control patients (healthy gastric mucosa), patients with gastritis, and patients with gastric cancer. The presence of Helicobacter pylori was determined, and the associations between H. pylori infection, levels of miRNA-181c expression, and gastric disease were also analyzed. METHODS: A total of 158 subjects were included in the study, and the three groups were respectively composed of 53 controls, 86 patients with gastritis, and 19 patients with gastric cancer...
December 15, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29241299/nmr-elucidation-of-monomer-dimer-transition-and-conformational-heterogeneity-in-histone-like-dna-binding-protein-of-helicobacter-pylori-hup
#4
Nancy Jaiswal, Nisha Raikwal, Himanshu Pandey, Nipanshu Agarwal, Ashish Arora, Krishna Mohan Poluri, Dinesh Kumar
Helicobacter pylori (H. pylori) colonizes under harsh acidic/oxidative stress conditions of human gastrointestinal tract and can survive there for infinitely longer durations of host life. The bacterium expresses several harbinger proteins to facilitate its persistent colonization under such conditions. One such protein in H. pylori is Histone like DNA binding protein (Hup) which in its homo-dimeric form binds to DNA to perform various DNA dependent cellular activities. Further, it also plays an important role in protecting the genomic DNA from oxidative stress and acidic denaturation...
December 14, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29239412/screening-natural-libraries-of-human-milk-oligosaccharides-against-lectins-using-car-esi-ms
#5
Amr El-Hawiet, Yajie Chen, Km Shams-Ud-Doha, Elena N Kitova, Pavel I Kitov, Lars Bode, Naim Hage, Franco H Falcone, John S Klassen
Human milk oligosaccharides (HMOs) afford many health benefits to breast-fed infants, such as protection against infection and regulation of the immune system, through the formation of non-covalent interactions with protein receptors. However, the molecular details of these interactions are poorly understood. Here, we describe the application of catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) for screening natural libraries of HMOs against lectins. The HMOs in the libraries were first identified based on molecular weights (MWs), ion mobility separation arrival times (IMS-ATs) and collision-induced dissociation (CID) fingerprints of their deprotonated anions...
December 14, 2017: Analyst
https://www.readbyqxmd.com/read/29238332/application-of-flp-frt-system-to-construct-unmarked-deletion-in-helicobacter-pylori-and-functional-study-of-gene-hp0788-in-pathogenesis
#6
Xiaofei Ji, Ying Wang, Jiaojiao Li, Qianyu Rong, Xingxing Chen, Ying Zhang, Xiaoning Liu, Boqing Li, Huilin Zhao
Helicobacter pylori is a Gram-negative, microaerophilic bacterium associated with human gastric diseases. Further investigations on virulence genes are still required to clarify the pathogenic mechanism of H. pylori and the heterogeneous problem of infection. In order to develop an efficient and accurate method to study gene functions in H. pylori pathogenesis, an unmarked deletion method for both a single gene and a large fragment was established based on the FLP-FRT recombination system. Using this method, the gene hp0788, encoding an outer membrane protein (HofF), was deleted...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29235736/primary-and-secondary-antibiotic-resistance-of-helicobacter-pylori-in-israeli-children-and-adolescents
#7
Michal Kori, Jacob Yahav, Rita Berdinstein, Haim Shmuely
BACKGROUND: Empiric treatment for Helicobacter pylori is influenced by antibiotic susceptibility of infecting strains. A rise in the resistance rate to clarithromycin and metronidazole has been reported in pediatric populations. OBJECTIVES: To assess the primary and secondary antibiotic resistance of H. pylori isolates in Israeli children and adolescents. METHODS: A retrospective review of H. pylori isolates cultured from antral biopsies of consecutive children aged 1 to 18 years, who were referred to the Pediatric Gastroenterology Unit, Kaplan Medical Center, over a 2...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29235197/superoxide-dismutase-from-helicobacter-pylori-suppresses-the-production-of-pro-inflammatory-cytokines-during-in-vivo-infection
#8
Andrew Stent, Alison L Every, Yok T Chionh, Garrett Z Ng, Philip Sutton
BACKGROUND: Helicobacter pylori has undergone considerable adaptation to allow chronic persistence within the gastric environment. While H. pylori-associated diseases are driven by an excessive inflammation, severe gastritis is detrimental to colonization by this pathogen. Hence, H. pylori has developed strategies to minimize the severity of gastritis it triggers in its host. Superoxide dismutase (SOD) is well known for its role in protecting against oxidative attack; less recognized is its ability to inhibit immunity, shown for SOD from mammalian sources and those of some bacterial species...
December 13, 2017: Helicobacter
https://www.readbyqxmd.com/read/29233672/time-latencies-of-helicobacter-pylori-eradication-after-peptic-ulcer-and-risk-of-recurrent-ulcer-ulcer-adverse-events-and-gastric-cancer-a-population-based-cohort-study
#9
Emma Sverdén, Nele Brusselaers, Karl Wahlin, Jesper Lagergren
BACKGROUND: Helicobacter pylori (H pylori) is associated with peptic ulcer disease and gastric cancer. AIM: To test how various lengths of delays in H pylori eradication therapy influence the risk of recurrent peptic ulcer, ulcer adverse events and gastric cancer. METHODS: This population-based nationwide Swedish cohort study included 29,032 patients receiving H pylori eradication therapy after peptic ulcer disease in 2005-2013. Pre-defined time intervals between date of peptic ulcer diagnosis and date of eradication therapy were analysed in relation to study outcomes...
December 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29232943/effect-of-helicobacter-pylori-eradication-on-the-regression-of-gastric-polyps-in-national-cancer-screening-program
#10
Su Youn Nam, Bum Joon Park, Kum Hei Ryu, Ji Hyung Nam
Background/Aims: Western guidelines recommend Helicobacter pylori eradication in H. pylori-associated gastric polyps; however, there is no standard guideline in Korea. The aim of this study is to assess the effect of H. pylori eradication on the regression of gastric hyperplastic polyps in National Cancer Screening Cohort, representative of general population. Methods: Among participants in National Cancer Screening Program, subjects who had H. pylori positive gastric hyperplastic polyps less than 10 mm and underwent follow-up endoscopy and H...
December 14, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29230485/-importance-of-functional-diagnostics-in-gastroenterology
#11
REVIEW
M Hollenbach, A Hoffmeister, J Rosendahl, J Mössner
In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion of abnormal intestinal bacterial colonization and using lactulose for measuring small intestinal transit time...
December 11, 2017: Der Internist
https://www.readbyqxmd.com/read/29229727/high-salt-conditions-alter-transcription-of-helicobacter-pylori-genes-encoding-outer-membrane-proteins
#12
John T Loh, Amber C Beckett, Matthew B Scholz, Timothy L Cover
Helicobacter pylori infection and high dietary salt intake are risk factors for the development of gastric adenocarcinoma. One possible mechanism by which a high salt diet could influence gastric cancer risk is by modulating H. pylori gene expression. In this study, we utilized RNA-seq methodology to compare the transcriptional profiles of H. pylori grown in media containing different concentrations of sodium chloride. We identified 118 differentially expressed genes (65 upregulated and 53 downregulated in response to high salt conditions), including multiple members of 14 operons...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29227738/antibiotic-resistance-of-helicobacter-pylori-in-iranian-children-a-systematic-review-and-meta-analysis
#13
Arshid Yousefi-Avarvand, Hamid Vaez, Mohsen Tafaghodi, Amir Hossein Sahebkar, Mohsen Arzanlou, Farzad Khademi
Antibiotic therapy for children infected with Helicobacter pylori is important. However, resistance to antibiotics is one of the main causes of treatment failure. This study was designed to evaluate the prevalence pattern of antibiotic resistance of H. pylori in Iranian children using a systematic review and meta-analysis of literature. A computerized search (until June 10, 2017) using related keywords in the national and international databases was performed. A total of 261 original articles on antibiotic resistance of H...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29227536/microrna-222-3p-associated-with-helicobacter-pylori-targets-hipk2-to-promote-cell-proliferation-invasion-and-inhibits-apoptosis-in-gastric-cancer
#14
Xiaoyan Tan, Haiying Tang, Jian Bi, Na Li, Yujie Jia
Gastric cancer ranks as the second leading cause of malignancy-related death worldwide, and always diagnosed at advanced stage. MicroRNA-222-3p (miR-222-3p) is aberrantly upregulated in various malignant tumors including gastric cancer, but its role and underlying molecular mechanisms in gastric cancer remain largely unknown. Helicobacter pylori (H. pylori) infection acts as a trigger in the development of gastric cancer, and increasing evidence suggests that H. pylori affects microRNA expression. In this study, gastric cancer tissue samples were divided into H...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29226407/editorial-recurrence-of-helicobacter-pylori-infection-still-the-same-after-all-these-years%C3%A2-authors-reply
#15
EDITORIAL
Y Hu, J-H Wan, X-Y Li, Y Zhu, D Y Graham, N-H Lu
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29226140/prevalence-of-helicobacter-pylori-vaca-genotypes-and-caga-gene-in-dental-plaque-of-asymptomatic-mexican-children
#16
Alejandra Mendoza-Cantú, Víctor Hugo Urrutia-Baca, Cynthia Sofía Urbina-Ríos, Myriam Angélica De la Garza-Ramos, Martha Elena García-Martínez, Hilda H H Torre-Martínez
The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated the prevalence of H. pylori and the presence of vacA/cagA genotypes in the oral cavity of Mexican children without dyspeptic symptoms. The gingival status was measured, and dental plaque samples (n = 100) were taken...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225907/changes-in-the-gut-microbiota-composition-and-the-plasma-ghrelin-level-in-patients-with-helicobacter-pylori-infected-patients-with-eradication-therapy
#17
Hidetaka Yanagi, Ayumi Tsuda, Masashi Matsushima, Shunsuke Takahashi, Genki Ozawa, Yasuhiro Koga, Atsushi Takagi
Objective: To investigate the influence of antimicrobials on both the gut microbiota structure and the plasma ghrelin level using Helicobacter pylori-infected patients who underwent eradication therapy. Design: Twenty H. pylori-infected patients (mean age 68.3 years old) who underwent eradication therapy participated in the study. For the therapy, patients had 1 week of triple therapy consisting of amoxicillin, clarithromycin and proton-pump inhibitors. Stool and blood samples were obtained before (S1), immediately after (S2) and/or 3 months after (S3) the therapies...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29225268/two-cases-of-lanthanum-deposition-in-the-stomach-in-the-absence-of-helicobacter-pylori-infection
#18
Masaya Iwamuro, Haruo Urata, Takehiro Tanaka, Seiji Kawano, Yoshiro Kawahara, Katsuhiko Kimoto, Hiroyuki Okada
In this case report, we describe two patients who showed a diffusely whitish mucosa in the posterior wall and the lesser curvature of the gastric body. The patients were serologically- and histopathologically-negative for Helicobacter pylori. Random biopsy specimens from the stomach revealed no regenerative changes, intestinal metaplasia, and/or foveolar hyperplasia in either of the patients. Although lanthanum deposition in the gastric mucosa has been reported to occur in close association with H. pylori-associated gastritis, our patients tested negative for H...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29223485/preventive-effect-of-anti-vaca-egg-yolk-immunoglobulin-igy-on-helicobacter-pylori-infected-mice
#19
Kyung Sook Hong, Mi-Ran Ki, H M Arif Ullah, Eun-Joo Lee, Yong Deuk Kim, Myung-Jin Chung, Ahmed K Elfadl, Jin-Kyu Park, Kyu-Shik Jeong
BACKGROUND: Helicobacter pylori, a gram-negative bacterium, is the causative agent of gastric disorders and gastric cancer in the human stomach. Vacuolating cytotoxin A (VacA) is among the multi-effect protein toxins released by H. pylori that enables its persistence in the human stomach. METHODS: To evaluate the effect of anti-VacA egg yolk immunoglobulin (anti-VacA IgY) on H. pylori infection, a highly specific anti-VacA IgY was produced from egg yolks of hens immunized with a mixture of two purified recombinant VacAs...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29222050/effects-of-the-rna-binding-protein-ksrp-on-innate-immune-response-against-helicobacter-pylori-infection-in-mice
#20
Ningzhe Li, Mei Cao, Sijun Yi, Juan Cheng, Lei Wang, Yuwei Tao, Daoyan Wu, Jingshan Peng, Mao Zhang, Panpan Qi, Jian Zhao
Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous inflammatory-related genes that participate in complex biological response of cells to harmful stimuli. Here we studied effects of the KH-type splicing regulatory protein (KSRP), a RNA-binding protein, on innate immune response against H...
December 5, 2017: Biochemical and Biophysical Research Communications
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