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h pylory

Keita Kai, Masaaki Satake, Osamu Tokunaga
A depressed lesion was found at a gastric angle of 76-year-old Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection (ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae...
July 14, 2018: World Journal of Gastroenterology: WJG
María I Taborda, Gisela Aquea, Yenny Nilo, Karla Salvatierra, Nicolás López, Sergio López, Gustavo Bresky, Juan A Madariaga, Vittorio Zaffiri, Sergio Häberle, Giuliano Bernal
The aim of this study was to develop a non-invasive diagnostic test for the detection of Helicobacter pylori in stool samples from digestive symptomatic patients, using a new protocol of nested-qPCR. A total of 143 patients were invited to participate in the study. A gastric biopsy of each patient was collected for Rapid Urease Testing (RUT) and histology by Giemsa stain. A fecal sample for nested-qPCR analysis was also obtained. DNA was extracted from the fecal samples, and conventional PCR followed by qPCR of the ureC gene of H...
March 9, 2018: Polish Journal of Microbiology
L E Bartels, A B Pedersen, N R Kristensen, P Jepsen, H Vilstrup, K Stengaard-Pedersen, J F Dahlerup
OBJECTIVE: Rheumatoid arthritis (RA) is an autoinflammatory disease caused by genetic susceptibility and environmental triggers, which include infectious agents. Helicobacter pylori, a bacterium that frequently colonizes the stomach, is associated with the development of certain autoinflammatory disorders. This study examined a possible association between H. pylori infection and RA. METHOD: This cohort study was performed in the Central Denmark Region. Patients were enrolled from primary healthcare centres after a urea breath test (UBT) for H...
July 17, 2018: Scandinavian Journal of Rheumatology
Naoyoshi Mori, Yuuki Nishiura, Daisuke Suga, Isao Moritani, Yutaka Yamanaka, Yumi Ooya, Hidekazu Inoue, Koujirou Takase, Masato Hioki, Katsuya Shiraki
Gastric acid inhibition during treatment is important for the eradication of Helicobacter pylori ( H. pylori ) infection. A novel potassium-competitive acid blocker, vonoprazan (VPZ), has been demonstrated to achieve high eradication rates; however, the efficacy of second-line treatment in failures of VPZ-based triple therapy has not been well studied. The aim of the current study was to determine the efficacy of VPZ in a first-line regimen for H. pylori eradication, and the efficacy of a second-line regimen using metronidazole (MTZ) in failures with the first-line regimen...
August 2018: Biomedical Reports
Li-Wei Chen, Sheng-Fong Kuo, Chih-Hung Chen, Cheng-Hung Chien, Chih-Lang Lin, Rong-Nan Chien
Helicobacter pylori (H. pylori) infection can induce chronic inflammation and is associated with insulin resistance, metabolic syndrome and body mass index (BMI, kg/m2 ) changes. This study aimed to evaluate the association between H. pylori infection and overweight/obesity. This research was a cross-sectional study conducted from March 2014 to November 2016, using data from the three districts in the northeastern region of Taiwan. The inclusion criteria were an age >30 years and the absence of pregnancy...
July 16, 2018: Scientific Reports
Piyumali Sandareka Arachchi, Manjula Manoji Weerasekera, Bimalka Seneviratne, Deepaka Weerasekera, Neluka Fernando, Chinthika Prabhashinie Gunasekara
OBJECTIVE: The study aimed to compare the usefulness of two staining methods for imprint cytology for diagnosis of Helicobacter pylori infection. Gastric biopsy specimens (from dyspeptic patients attending routine upper gastrointestinal endoscopy) were placed on glass slides to obtain imprints. The imprints were stained with Toluidine blue and Giemsa stains separately and observed under ×400 magnification using a light microscope. Imprinted biopsies were sectioned and stained with H & E stain and Giemsa stain for histological analysis...
July 16, 2018: BMC Research Notes
Tao Xi, Hai Liu, Wei Liu, Zhoulin Tan, Zhiqin Zeng, Huimin Yang, Shuanghui Luo, Linlin Wang, Yingying Xing
The immunogenicity of oral subunit vaccines is poor partly due to the harsh milieu of gastrointestinal (GI) tract. For some pathogens that restrictedly inhabit in GI tract, a vaccine that works in situ may provide more potent protection than that vaccinates parenterally. Yet, none appropriate delivery system is available for oral subunit vaccines. In this study, we designed HP55/Poly(n-butylcyanoacrylate) (PBCA) nanoparticles (NPs) to carry Helicobacter pylori (H. pylori) subunit vaccine CCF for oral administration in a prophylactic mice model...
July 16, 2018: Molecular Pharmaceutics
Jun-Hyung Cho, Seong Ran Jeon, Hyun Gun Kim, So-Young Jin, Suyeon Park
BACKGROUND AND AIMS: The Helicobacter pylori eradication rate using conventional triple therapy has decreased due to clarithromycin (CAM) resistance in H. pylori. Recently, dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) can be used to detect H. pylori and point mutations in the 23S ribosomal RNA gene causing CAM resistance. This study aimed to evaluate the success rate and cost-effectiveness of tailored H. pylori eradication using DPO-PCR. METHODS: The H...
July 16, 2018: Journal of Gastroenterology and Hepatology
Lihua Huang, Yinjie Guo, Dan Cao, Xiaoming Liu, Linfang Zhang, Ke Cao, Tingzi Hu, Yong Qi, Canxia Xu
The present study aimed to explore the effects of Helicobacter pylori (H. pylori) infection on the expression of transcription factor GATA binding protein 3 (GATA-3) and connexin 32 (Cx32) in cultured gastric mucosa cells, and their association with each other. GES-1 cells were co-cultured with East Asian type cytotoxin-associated gene A+ H. pylori in the H. pylori group, and without H. pylori culture in the control group. Additionally, Mongolian gerbils were gavaged with H. pylori, and later the gastric antrum tissues were collected...
August 2018: Oncology Letters
Mostefa Moubri, Christophe Burucoa, Nicolas Kalach, R Rezki Larras, Nouria Nouar, Fawsia Mouffok, Zakia Arrada
We aimed to evaluate in an Algerian pediatric population the diagnostic performances of the IDEIA HpStAR noninvasive stool antigen test (Oxoid, Cambridge, UK) to detect Helicobacter pylori infection before and after eradication therapy. A prospective study including 158 symptomatic Algerian children was conducted. Patients were initially diagnosed with invasive (culture, histology, and rapid urease test) and noninvasive tests (urea breath test and IDEIA HpStAR test). Infected patients were treated, and 101 were controlled after treatment with two invasive (culture and histology) and two noninvasive tests (urea breath test and IDEIA HpStAR test)...
July 10, 2018: Journal of Tropical Pediatrics
Qi Liu, Wei-Kang Shi, Shen-Zhen Ren, Wei-Wei Ni, Wei-Yi Li, Hui-Min Chen, Pei Liu, Jing Yuan, Xiao-Su He, Jia-Jia Liu, Peng Cao, Pu-Zhen Yang, Zhu-Ping Xiao, Hai-Liang Zhu
A novel series of aniline-containing hydroxamic acids were designed, synthesized and evaluated as anti-virulence agents for the treatment of gastritis and gastric ulcer caused by Helicobacter pylori. In vitro enzyme-based screen together with in vivo assays and structure-activity relationship (SAR) studies led to the discovery of three potent urease inhibitors 3-(3,5-dichlorophenylamino)N-hydroxypropanamide (3a), 3-(2-chlorophenylamino)N-hydroxypropanamide (3d) and 3-(2,4-dichlorophenylamino)N-hydroxypropanamide (3n)...
July 2, 2018: European Journal of Medicinal Chemistry
Araceli Benavides-Ward, Fernando Vasquez-Achaya, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Fernando Mazulis, Numan Urteaga, Juana Del Valle-Mendoza
OBJECTIVE: To determine the variations in the composition of the intestinal microbiota in asymptomatic children infected with Helicobacter pylori in comparison with children without the infection. RESULTS: Children infected with H. pylori doubled their probability of presenting 3 of 9 genera of bacteria from the gut microbiota, including: Proteobacteria (p = 0.008), Clostridium (p = 0.040), Firmicutes (p = 0.001) and Prevotella (p = 0.006) in comparison to patients without the infection...
July 13, 2018: BMC Research Notes
Natalie J Bitto, Paul J Baker, Jennifer K Dowling, Georgie Wray-McCann, Amanda De Paoli, Le Son Tran, Pak Ling Leung, Katryn J Stacey, Ashley Mansell, Seth L Masters, Richard L Ferrero
Outer membrane vesicles (OMVs) are constitutively produced by Gram-negative bacteria both in vivo and in vitro. These lipid-bound structures carry a range of immunogenic components derived from the parent cell, which are transported into host target cells and activate the innate immune system. Recent advances in the field have shed light on some of the multifaceted roles of OMVs in host-pathogen interactions. In this study, we investigated the ability of OMVs from two clinically important pathogens, Pseudomonas aeruginosa and Helicobacter pylori, to activate canonical and non-canonical inflammasomes...
July 12, 2018: Immunology and Cell Biology
Baris Yilmaz, Huseyin Koseoglu, Yusuf Coskun, Murat Deveci, Murat Kekilli
Introduction: Helicobacter pylori infection is encountered in more than 50% of the world population. A high rate of clarithromycin resistance is observed among Helicobacter pylori strains in some regions because clarithromycin is a drug commonly used for the treatment of other infections. Aim: To identify an efficient eradication protocol for patients infected with H. pylori and to suggest an alternative first-line therapy particularly in countries with high clarithromycin resistance...
2018: Przegla̜d Gastroenterologiczny
Wolfgang Fischbach, Peter Malfertheiner
BACKGROUND: Infection with Helicobacter pylori (H. pylori) is a major pathogenic factor for gastroduodenal ulcer disease and gastric carcinoma, as well as for other types of gastric and extragastric disease. As a result of changing epidemiologic conditions (e.g., immigration), changing resistance patterns with therapeutic implications, and new knowledge relating to the indications for pathogen eradication, the medical management of H. pylori is a dynamic process in need of periodic reassessment...
June 22, 2018: Deutsches Ärzteblatt International
Xingzhe Yang
BACKGROUND: Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, gastric cancer and gastrointestinal ulcers. Recent evidences have suggested that H. pylori infection is closely related to the occurrence of diseases. In recent years, studies have found that Helicobacter pylori infection is associated with the occurrence of acne rosacea...
July 11, 2018: BMC Infectious Diseases
Haijun Lei, Yuting Wen, Ahmed Elazab, Ee-Leng Tan, Yujia Zhao, Baiying Lei
Predicting the protein-protein interactions (PPIs) has played an important role in many applications. Hence, a novel computational method for PPIs prediction is highly desirable. PPIs endow with protein amino acid mutation rate and two physicochemical properties of protein (e.g., hydrophobicity, and hydrophilicity). Deep polynomial network (DPN) is well-suited to integrate these modalities since it can represent any function on a finite sample dataset via the supervised deep learning algorithm. We propose a multimodal DPN (MDPN) algorithm to effectively integrate these modalities to enhance prediction performance...
June 12, 2018: IEEE Journal of Biomedical and Health Informatics
Lan Liu, Hongwei Gao, Hongjuan Wang, Weihua Yu, Kongxi Zhu, Yuan Zhang, Jianqiang Guo
BACKGROUND The effects of Helicobacter pylori (H. pylori) infection on gastroesophageal reflux disease (GERD) remain unclear. The aim of this study was to compare the results of clinical esophageal function tests and the effect of H. pylori infection on GERD. MATERIAL AND METHODS A prospective clinical study included 124 patients diagnosed with GERD (four grades). H. pylori infection was determined by gastroscopy and a rapid urease test (RUT) to divide patients into an HP-positive and an HP-negative group. Esophageal function tests included high-resolution manometry (HRM), peristalsis break (PB), and 24-hour pH monitoring (composite pH DeMeester score)...
July 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hirotaka Nakashima, Hiroshi Kawahira, Hiroshi Kawachi, Nobuhiro Sakaki
Background: Deep learning is a type of artificial intelligence (AI) that imitates the neural network in the brain. We generated an AI to diagnose Helicobacter pylori ( H. pylori ) infection using blue laser imaging (BLI)-bright and linked color imaging (LCI). The aim of this pilot study was to establish an AI diagnosing system that predicts H. pylori infection status using endoscopic images to improve the accuracy and productivity of endoscopic examination. Methods: A total of 222 enrolled subjects (105 H...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Kwok Ho Lam, Chaolun Xue, Kailei Sun, Huawei Zhang, Wendy Wai Ling Lam, Zeyu Zhu, Juliana Tsz Yan Ng, William E Sause, Paphavee Lertsethtakarn, Kwok-Fai Lau, Karen M Ottemann, Shannon Wing Ngor Au
Bacterial flagella are rotary nano-machines that contribute to bacterial fitness in many settings, including host colonization. The flagellar motor relies on the multiprotein flagellar motor-switch complex to govern flagellum formation and rotational direction. Different bacteria exhibit great diversity in their flagellar motors. One such variation is exemplified by the motor-switch apparatus of the gastric pathogen Helicobacter pylori , which carries an extra switch protein, FliY, along with the more typical FliG, FliM, and FliN proteins...
July 10, 2018: Journal of Biological Chemistry
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