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https://www.readbyqxmd.com/read/30221659/analysis-of-virulence-diversity-of-73-helicobacter-pylori-strains-isolated-in-guizhou-province-china
#1
Lin Yin, Fang Liu, Changcheng Guo, Qiong Wang, Ke Pan, Liangbi Xu, Yan Xiong, Yingting Chen, Zhenghong Chen
The present study aimed to investigate the virulence diversity of Helicobacter pylori (H. pylori) in major ethnic groups residing in Guizhou province, China, and its association with clinical outcomes. Gastric mucosal biopsies were collected from the pylorus of patients with gastrointestinal disorders. H. pylori was identified by colonial morphology, Gram staining, a urease test and H. pylori‑specific 16S rRNA gene fragment PCR amplification. DNA was extracted from pure culture and used for virulence gene analysis...
September 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30219982/gastric-cancer-screening-in-common-variable-immunodeficiency
#2
David K van der Poorten, Duncan McLeod, Golo Ahlenstiel, Scott Read, Avelyn Kwok, Cositha Santhakumar, Milan Bassan, Suzanne Culican, David Campbell, Sue W J Wong, Louise Evans, Bilel Jideh, Alisa Kane, Constance H Katelaris, Karuna Keat, Yanna Ko, Jessie A Lee, Sandhya Limaye, Ming Wei Lin, Ari Murad, Martina Rafferty, Dan Suan, Sanjay Swaminathan, Sean D Riminton, Catherine Toong, Lucinda J Berglund
Individuals with common variable immunodeficiency (CVID) have an increased risk of gastric cancer, and gastrointestinal lymphoma, yet screening for premalignant gastric lesions is rarely offered routinely to these patients. Proposed screening protocols are not widely accepted and are based on gastric cancer risk factors that are not applicable to all CVID patients. Fifty-two CVID patients were recruited for screening gastroscopy irrespective of symptoms or blood results and were compared to 40 controls presenting for gastroscopy for other clinical indications...
September 15, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/30219037/differential-expression-of-mirna-146a-and-mirna-155-in-gastritis-induced-by-helicobacter-pylori-infection-in-paediatric-patients-adults-and-an-animal-model
#3
Ana Caren Cortés-Márquez, Sandra Mendoza-Elizalde, Francisco Arenas-Huertero, Jimena Trillo-Tinoco, Pedro Valencia-Mayoral, Alejandra Consuelo-Sánchez, Jonathan Zarate-Franco, Ada Ruth Dionicio-Avendaño, José de Jesús Herrera-Esquivel, Elio Germán Recinos-Carrera, Christian Colín-Valverde, Sandra Rivera-Gutiérrez, Alfonso Reyes-López, Juan Carlos Vigueras-Galindo, Norma Velázquez-Guadarrama
BACKGROUND: Helicobacter pylori is a major aetiologic agent associated with gastritis. H. pylori infections increase the expression of the Toll-like receptor (TLR), which in turn modulates the expression of microRNA (miRNA)-146a and miRNA-155. The objective of this study was to compare the expression of miRNA-146a and miRNA-155 in gastric lesions of paediatric and adult patients with different pathologies and in Mongolian gerbils (Meriones unguiculatus) infected with H. pylori 26,695...
September 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30217998/the-gastric-mucosal-associated-microbiome-in-patients-with-gastric-polyposis
#4
Rongrong Ren, Zikai Wang, Huaibo Sun, Xuefeng Gao, Gang Sun, Lihua Peng, Bin Yan, Yunsheng Yang
The characteristics of the gastric microbiota in patients with gastric polyposis (GP) remain unclear. Given this we collected gastric antrum and gastric body biopsies from healthy controls (HC.A and HC.B group) and gastric antrum, gastric body and polyp biopsies from patients with multiple gastric polyps (GP.A, GP.B and GP.P group) for 16S rDNA sequencing. The results showed that the diversity of the gastric flora in the GP group was significantly lower than that of the HC group. The gastric flora composition of the GP group was significantly different from the HC group...
September 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30217524/intranasal-immunization-with-immunodominant-epitope-peptides-derived-from-hpaa-conjugated-with-cpg-adjuvant-protected-mice-against-helicobacter-pylori-infection
#5
Wu-Chen Yang, Hong-Wu Sun, He-Qiang Sun, Han-Mei Yuan, Bin Li, Hai-Bo Li, Jian Hu, Yun Yang, Quan-Ming Zou, Hong Guo, Chao Wu, Li Chen
HpaA is considered to be an effective protective antigen for vaccination against Helicobacter pylori (H. pylori) infection. Oral immunization with HpaA significantly decreases bacterial colonization in H. pylori infected mice. In this study, we investigated whether subcutaneous or intranasal immunization with HpaA could protect against H. pylori infection. Mice immunized subcutaneously with HpaA in Complete Freund's adjuvant, but not mice intranasally immunized with HpaA in CpG adjuvant acquired protection against H...
September 11, 2018: Vaccine
https://www.readbyqxmd.com/read/30213786/methylation-and-expression-of-non-clustered-protocadherins-encoding-genes-and-risk-of-precancerous-gastric-lesions-in-a-high-risk-population
#6
Si Wu, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Wei-Cheng You, Kai-Feng Pan
Non-clustered protocadherins (PCDHs) family is a group of cell-cell adhesion molecules. We have found differentially methylated genes in the non-clustered PCDHs family associated with Helicobacter pylori (H. pylori) infection in prior genome-wide methylation analysis. To further investigate the methylation and expression of non-clustered PCDHs encoding genes in H. pylori-related gastric carcinogenesis process, four candidate genes including PCDH7, PCDH10, PCDH17 and PCDH20 were selected, which were reported to be tumor suppressors for digestive cancers...
September 13, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30212456/detection-of-genetic-alterations-in-gastric-cancer-patients-from-saudi-arabia-using-comparative-genomic-hybridization-cgh
#7
Fehmida Bibi, Isse Ali, Muhammad Imran Naseer, Hussein Sheikh Ali Mohamoud, Muhammad Yasir, Sana Akhtar Alvi, Asif Ahmed Jiman-Fatani, Ali Sawan, Esam Ibraheem Azhar
BACKGROUND: The present study was conducted to discover genetic imbalances such as DNA copy number variations (CNVs) associated with gastric cancer (GC) and to examine their association with different genes involved in the process of gastric carcinogenesis in Saudi population. METHODS: Formalin-fixed paraffin-embedded (FFPE) tissues samples from 33 gastric cancer patients and 15 normal gastric samples were collected. Early and late stages GC samples were genotyped and CNVs were assessed by using Illumina HumanOmni1-Quad v...
2018: PloS One
https://www.readbyqxmd.com/read/30210707/low-expression-of-the-long-non-coding-rna-nr_026827-in-gastric-cancer
#8
Fengyun Zhong, Meili Zhu, Kaijian Gao, Ping Xu, Huan Yang, Duanmin Hu, Dawei Cui, Min Wang, Xiaofang Xie, Yan Wei, Haifang Zhang, Hong Du
AIM: The contribution of long non-coding RNAs (lncRNAs) to gastric cancer associated with Helicobacter pylori ( H. pylori ) infection remains largely unknown. Therefore, the present study aimed to investigate the expression of a lncRNA NR_026827 in gastric epithelial cells infected with H. pylori , and demonstrate its expression characteristic in gastric cancer. MATERIALS AND METHODS: Gastric epithelial cell line cells, GES-1, were cultured and infected with H. pylori ...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30210122/association-between-functional-dyspepsia-and-gastric-depressive-erosions-in-japanese-subjects
#9
Fumio Tanaka, Kazunari Tominaga, Yoshiko Fujikawa, Tamami Morisaki, Koji Otani, Shuhei Hosomi, Yasuaki Nagami, Noriko Kamata, Koichi Taira, Akemi Nakano, Tatsuo Kimura, Hirokazu Yamagami, Tetsuya Tanigawa, Hiroyasu Morikawa, Shinya Fukumoto, Toshio Watanabe, Norifumi Kawada, Kazuto Hirata, Yasuhiro Fujiwara
Objective The association between functional dyspepsia (FD) and endoscopic findings has not been fully elucidated. Helicobacter pylori infection is considered a key factor in the pathophysiology of FD. The Kyoto Classification of Gastritis (KCG) was proposed in 2014 to evaluate endoscopic findings based on the H. pylori status. We investigated the endoscopic findings associated with FD according to the KCG. Methods This cross-sectional study included subjects who underwent esophagogastroduodenoscopy during a medical health check-up...
September 12, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30195645/prevalence-of-the-helicobacter-pylori-homa-and-homb-genes-and-their-correlation-with-histological-parameters-in-children
#10
Anja Šterbenc, Mario Poljak, Nina Zidar, Boštjan Luzar, Matjaž Homan
The significance of Helicobacter pylori (H. pylori) virulence genes such as cagA and vacA has been extensively studied in children; however, data regarding the significance of homA and homB genes are scarce. The aim of our study was to evaluate the prevalence and clinical relevance of these genes in Slovenian children. All children diagnosed with H. pylori infection between 1993 and 2013 were included in the study (n = 343). DNA was extracted from biopsy specimens previously used for the rapid urease test...
September 6, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30195448/loss-of-tight-junction-protein-claudin-18-promotes-progressive-neoplasia-development-in-mouse-stomach
#11
Susan J Hagen, Lay-Hong Ang, Yi Zheng, Salih N Karahan, Jessica Wu, Yaoyu E Wang, Tyler J Caron, Aniket P Gad, Sureshkumar Muthupalani, James G Fox
BACKGROUND & AIMS: Loss of claudin 18 (CLDN18), a membrane-spanning tight junction protein, occurs during early stages of development of gastric cancer and associates with shorter survival times of patients. We investigated whether loss of CLDN18 occurs in mice that develop intraepithelial neoplasia with invasive glands due to infection with Helicobacter pylori, and whether loss is sufficient to promote the development of similar lesions in mice with or without H pylori infection...
September 6, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30191734/in-the-quest-for-new-targets-for-pathogen-eradication-the-adenylosuccinate-synthetase-from-the-bacterium-helicobacter-pylori
#12
Ante Bubić, Natalia Mrnjavac, Igor Stuparević, Marta Łyczek, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Marija Luić, Ivana Leščić Ašler
Adenylosuccinate synthetase (AdSS) is an enzyme at regulatory point of purine metabolism. In pathogenic organisms which utilise only the purine salvage pathway, AdSS asserts itself as a promising drug target. One of these organisms is Helicobacter pylori, a wide-spread human pathogen involved in the development of many diseases. The rate of H. pylori antibiotic resistance is on the increase, making the quest for new drugs against this pathogen more important than ever. In this context, we describe here the properties of H...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/30191728/coptisine-induced-inhibition-of-helicobacter-pylori-elucidation-of-specific-mechanisms-by-probing-urease-active-site-and-its-maturation-process
#13
Cailan Li, Ping Huang, Kambo Wong, Yifei Xu, Lihua Tan, Hanbin Chen, Qiang Lu, Chaodan Luo, Chunlai Tam, Lixiang Zhu, Ziren Su, Jianhui Xie
In this study, we examined the anti-Helicobactor pylori effects of the main protoberberine-type alkaloids in Rhizoma Coptidis. Coptisine exerted varying antibacterial and bactericidal effects against three standard H. pylori strains and eleven clinical isolates, including four drug-resistant strains, with minimum inhibitory concentrations ranging from 25 to 50 μg/mL and minimal bactericidal concentrations ranging from 37.5 to 125 μg/mL. Coptisine's anti-H. pylori effects derived from specific inhibition of urease in vivo...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/30191635/the-effect-of-antioxidants-on-helicobacter-pylori-eradication-a-systematic-review-with-meta-analysis
#14
REVIEW
Yao-Bin Yang-Ou, Yi Hu, Yin Zhu, Nong-Hua Lu
BACKGROUND: The efficacy and safety of the addition of antioxidants to triple or quadruple therapy were unclear. MATERIALS AND METHODS: This systematic review was performed in accordance with the PRISMA 2009 guidelines. A systematic search of PubMed, EMBASE, and the Cochrane Library databases was conducted to identify potentially relevant publications using the following keywords: ([Helicobacter pylori] or [H. pylori] or [Hp]) and ([antioxidant] or [vitamin] or [N-acetylcysteine] or [curcumin] or [cranberry])...
September 6, 2018: Helicobacter
https://www.readbyqxmd.com/read/30186138/severe-gastritis-after-administration-of-nivolumab-and-ipilimumab
#15
Yoshito Nishimura, Miho Yasuda, Kazuki Ocho, Masaya Iwamuro, Osamu Yamasaki, Takehiro Tanaka, Fumio Otsuka
Immune checkpoint inhibitors such as ipilimumab, a cytotoxic T-lymphocyte-associated antigen-4 inhibitor, have been widely used for advanced malignancies. As these inhibitors improve antitumor immunity via T-cell modulation, immune-mediated adverse events associated with T-cell activation, such as colitis, might occur. Herein, we describe a 75-year-old Japanese woman with metastatic malignant melanoma who developed hemorrhagic gastritis after ipilimumab treatment. There was no macroscopic or clinical improvement of gastritis after proton pump inhibitor treatment...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30185727/-pharmacological-characteristics-and-clinical-efficacies-of-a-novel-potassium-competitive-acid-blocker-vonoprazan-fumarate
#16
Jun Matsukawa, Nobuhiro Inatomi, Haruyuki Nishida, Yasuhiro Tsukimi
Proton pump inhibitors (PPIs) inhibit H+ , K+ -ATPase, an enzyme which is the final step of gastric acid secretion and is selectively located in the gastric parietal cells. PPIs block the enzyme in a covalent and irreversible binding manner, thus providing better efficacy than previous pharmacological agents such as antacids and histamine H2 receptor antagonists. Although PPIs have been the first-line therapeutic option for acid related diseases (ARDs), there are several limitations to their efficacy, i.e. short half-life in blood, insufficient acid suppression especially at night, necessity of repeated dosages for full action, and large variation in efficacy among patients due to CYP2C19 polymorphism...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/30185314/the-natural-history-of-gastrointestinal-bleeding-in-patients-without-an-obvious-source
#17
Leen Khoury, David Hill, Miroslav Kopp, Melissa Panzo, Tushar Bajaj, Carson Schell, Andrew Corrigan, Ryan Rodriguez, Stephen M Cohn
With the advent of proton pump inhibitors and H. Pylori treatment, the old dogma "the most common cause of lower GI bleeding is upper GI bleeding" may no longer be valid. We sought to determine the most common causes of GI bleeding in patients without an obvious source and their clinical outcomes. We queried our hospital database for GI hemorrhage during 2015, excluding patients with obvious sources such as hematemesis or anal pathology. We collected data from patients with GI bleeding defined as bright red blood per rectum, melena, or a positive fecal occult blood test...
August 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/30181372/bifunctional-enzyme-spot-is-involved-in-biofilm-formation-of-helicobacter-pylori-with-multidrug-resistance-by-upregulating-efflux-pump-hp1174-glup
#18
Xiaoran Ge, Yuying Cai, Zhenghong Chen, Sizhe Gao, Xiwen Geng, Ya Li, Yan Li, Jihui Jia, Yundong Sun
The drug resistance of Helicobacter pylori ( H. pylori ) is gradually becoming a serious problem. Biofilm formation is an important factor that leads to multidrug resistance in bacteria. The ability of H. pylori to form biofilms on the gastric mucosa is known. However, there are few studies on the regulatory mechanisms of H. pylori biofilm formation and multidrug resistance. Guanosine 3'-diphosphate 5'-triphosphate and guanosine 3',5'-bispyrophosphate [(p)ppGpp] are global regulatory factors and are synthesized in H...
September 4, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30179876/smoking-and-drinking-did-not-increase-the-failure-of-therapeutic-helicobacter-pylori-eradication-by-vonoprazan-clarithromycin-and-amoxicillin
#19
Yoshimichi Takara, Hiroyoshi Endo, Ryo Nakano, Kojiro Kawachi, Hidenori Hidaka, Takuya Matsunaga, Nanae Tsuruoka, Yasuhisa Sakata, Ryo Shimoda, Megumi Hara, Kazuma Fujimoto
AIMS: The influence of lifestyle-related factors, including smoking and drinking, was evaluated for Helicobacter pylori eradication therapy with vonoprazan or proton pump inhibitors (PPIs). METHODS: Between 2012 and 2016, the medical records of 620 patients receiving H. pylori eradication therapy at Saiseikai Karatsu Hospital were evaluated. Patients had received vonoprazan (20 mg) or PPIs with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 days...
September 4, 2018: Digestion
https://www.readbyqxmd.com/read/30179659/structural-flexibility-in-the-helicobacter-pylori-peptidyl-prolyl-cis-trans-isomerase-hp0175-is-achieved-through-an-extension-of-the-chaperone-helices
#20
Ayat Yaseen, Gerald F Audette
Helicobacter pylori infects the gastric epithelium of half the global population, where infections can persist into adenocarcinomas and peptic ulcers. H. pylori secretes several proteins that lend to its pathogenesis and survival including VacA, CagA, γ-glutamyltransferase and HP0175. HP0175, also known as HpCBF2, classified as a peptidyl-prolyl cis,trans-isomerase, has been shown to induce apoptosis through a cascade of mechanisms initiated though its interaction with toll like receptor 4 (TLR4). Here, we report the structure of apo-HP0175 at 2...
September 1, 2018: Journal of Structural Biology
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