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https://www.readbyqxmd.com/read/29026594/subtypes-of-chronic-gastritis-in-patients-with-celiac-disease-before-and-after-gluten-free-diet
#1
Dolores Gabrieli, Fabiana Ciccone, Annalisa Capannolo, Angelo Viscido, Giorgio Valerii, Donatella Serva, Stefano Necozione, Gino Coletti, Giuseppe Calvisi, Dina Melideo, Giuseppe Frieri, Giovanni Latella
BACKGROUND: Celiac disease (CD) often manifests with dyspeptic symptoms and chronic gastritis is a common finding. AIM: To evaluate the frequency of lymphocytic gastritis (LG), chronic active gastritis (CAG), and chronic inactive gastritis (CIG) in patients with CD, before and after gluten-free diet (GFD). METHODS: A five-year prospective study including all consecutive patients with a new diagnosis of CD was conducted. Gastric and duodenal biopsy specimens taken both at the time of the CD diagnosis and at the first endoscopic control after 18-24 months on GFD were evaluated...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026593/antibiotic-resistance-and-gyra-mutation-affect-the-efficacy-of-10-day-sitafloxacin-metronidazole-esomeprazole-therapy-for-helicobacter-pylori-in-penicillin-allergic-patients
#2
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Tatsuhiro Masaoka, Takanori Kanai
BACKGROUND AND AIM: Helicobacter pylori (H. pylori) eradication regimen has not been standardized for patients with penicillin allergy. We investigated the association between the efficacy of a 10-day sitafloxacin, metronidazole, and esomeprazole triple regimen and antibiotic resistance, in patients with penicillin allergy. METHODS: Penicillin-allergic patients infected with H. pylori were enrolled between March 2014 and November 2015. The minimum inhibitory concentrations (MICs) of sitafloxacin and metronidazole, and the gyrA mutation status of the H...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29024639/helicobacter-pylori-makes-a-molecular-incision-to-gain-epithelial-entry
#3
Jennifer M Noto, Richard M Peek
Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epithelial cells to drive carcinogenesis. In this issue of Cell Host & Microbe, Tegtmeyer et al. (2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to access the basolateral compartment and trigger pathogenesis.
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29023421/helicobacter-pylori-vacuolating-toxin-and-gastric-cancer
#4
REVIEW
Mark S McClain, Amber C Beckett, Timothy L Cover
Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer...
October 12, 2017: Toxins
https://www.readbyqxmd.com/read/29022245/prevalence-of-eosinophilic-esophagitis-in-patients-with-gastroesophageal-reflux-symptoms-a-cross-sectional-study-from-a-tertiary-care-hospital-in-north-india
#5
Bhaskarjyoti Baruah, Tarun Kumar, Prasenjit Das, Bhaskar Thakur, Vishnubatla Sreenivas, Vineet Ahuja, Siddhartha Datta Gupta, Govind K Makharia
BACKGROUND: Eosinophilic esophagitis (EoE) is being recognized increasingly all over the globe; Indian data is however sparse. We screened patients with symptoms of gastroesophageal reflux disease (GERD) for presence of EoE in them. METHODS: Consecutive patients with symptoms suggestive of GERD underwent gastroduodenoscopy and esophageal biopsies, obtained from both the upper esophagus (5 cm below the upper esophageal sphincter) and lower esophagus (5 cm above gastroesophageal junction), as well as from any other endoscopically visible abnormal mucosa...
October 12, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29021786/a-new-role-for-helicobacter-pylori-urease-contributions-to-angiogenesis
#6
Deiber Olivera-Severo, Augusto F Uberti, Miguel S Marques, Marta T Pinto, Maria Gomez-Lazaro, Céu Figueiredo, Marina Leite, Célia R Carlini
Helicobacter pylori is a pathogen involved in gastric diseases such as ulcers and carcinomas. H. pylori's urease is an important virulence factor produced in large amounts by this bacterium. In previous studies, we have shown that this protein is able to activate several cell types like neutrophils, monocytes, platelets, endothelial cells, and gastric epithelial cells. Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. Here, we have analyzed the angiogenic potential of H...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29021509/nucleotide-binding-oligomerization-domain-1-and-gastrointestinal-disorders
#7
Tomohiro Watanabe, Naoki Asano, Masatoshi Kudo, Warren Strober
Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular sensor that detects small peptides derived from the cell wall component of intestinal microflora. NOD1 is expressed in both non-hematopoietic cells such as epithelial cells and hematopoietic cells such as antigen-presenting cells. Detection of its ligand by NOD1 leads to innate immune responses through activation of nuclear factor kappa B and type I interferon as well as induction of autophagy. Innate immune responses through NOD1 activation play an indispensable role both in host defense against microbial infection and in the development of gastrointestinal disorders...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29021452/a-case-of-familial-adenomatous-polyposis-with-multiple-helicobacter-negative-early-gastric-cancers-treated-by-endoscopic-submucosal-dissection
#8
Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29018268/biological-activity-of-intervenolin-analogs-with-a-phenyl-substituent
#9
Hikaru Abe, Manabu Kawada, Masayuki Igarashi, Shun-Ichi Ohba, Chigusa Hayashi, Chiharu Sakashita, Takumi Watanabe, Masakatsu Shibasaki
Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds (3-11) showed weak or no inhibitory activity toward the growth of MKN-74 gastric adenocarcinoma cells, even in the presence or absence of the corresponding Hs738 stromal cells, whereas 2-substituted analogs exhibited selective anti-Helicobacter pylori activity. Introduction of a pendant side chain on the nitrogen alleviated their acute toxicity in mice. The 2-phenyl-substituted analogs are reasonable structural templates for structure-activity relationship studies toward the development of anti-H...
October 11, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28992885/helicobacter-pylori-and-17%C3%AE-estradiol-induce-human-intrahepatic-biliary-epithelial-cell-abnormal-proliferation-and-oxidative-dna-damage
#10
Fei Ma, Yong Yang, Jian-Dong Wang, Zhi-Wei Quan, Di Zhou
BACKGROUND: Biliary cancers are more common in females, and previous studies have suggested that Helicobacter pylori (H. pylori) exists in the biliary system. However, the effects of H. pylori infection and estrogen on the biological behaviors of human biliary epithelium mucosa remain unknown. The present study aimed to clarify their effects on the proliferation, apoptosis, migration and oxidative DNA damage of a human intrahepatic biliary epithelial cell (HIBEC) line in vitro. METHODS: HIBECs were co-cultured with 17β-estradiol (at 10(-9) mol/L, 10(-7) mol/L, and 10(-5) mol/L) and H...
October 15, 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28992674/is-helicobacter-pylori-associated-functional-dyspepsia-correlated-with-dysbiosis
#11
REVIEW
Yeon-Ji Kim, Woo Chul Chung, Byung Wook Kim, Sung Soo Kim, Jin Il Kim, Na Jin Kim, Jinho Yoo, Soo Hwan Kim
Background/Aims: To assess the long-term effect of Helicobacter pylori eradication on symptomatic improvement according to the type of antibiotic and the duration of treatment in H. pylori-associated functional dyspepsia. Methods: We searched Pubmed, Embase, CINAHL, and the Cochrane library databases for randomized controlled trials written in English and undertaken up to August 2016 that met our eligibility criteria. The search methodology used combinations of the following keywords: Helicobacter pylori OR H...
October 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28990461/enrichment-of-helicobacter-pylori-mutant-strains-after-eradication-therapy-analyzed-by-gastric-wash-based-quantitative-pyrosequencing
#12
Ritsuko Oikawa, Yoshiyuki Watanabe, Shuichi Miyamoto, Yoshinori Sato, Shoko Ono, Katsuhiro Mabe, Hiroyuki Yamamoto, Mototsugu Kato, Fumio Itoh
The eradication of Helicobacter pylori reduces the risk of gastric cancer. A clear understanding of the factors underlying mixed infection with multiple clarithromycin-susceptible and clarithromycin-resistant H. pylori strains is necessary to design more effective therapies against H. pylori. We aimed to assess how the abundance and prevalence of H. pylori strains vary after clarithromycin-based eradication therapy. Using gastric wash samples, which represent the entire stomach, we sequentially analyzed the abundance and prevalence of H...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28990120/sequential-versus-concomitant-therapy-for-treatment-of-helicobacter-pylori-infection-an-updated-systematic-review-and-meta-analysis
#13
REVIEW
Youhua Wang, Rulin Zhao, Ben Wang, Qiaoyun Zhao, Zhen Li, Liya Zhu-Ge, Wenzhu Yin, Yong Xie
BACKGROUND: Sequential and concomitant therapies are two innovative therapies for Helicobacter pylori (H. pylori) eradication. However, the comparative efficacy and safety of these treatments are controversial. Therefore, we aimed to conduct an updated systematic review and meta-analysis of studies that compared these two treatments. METHODS: A search of PubMed, Embase, the Cochrane Library, and Web of Science was carried out. Randomized controlled trials (RCTs) that compared sequential with concomitant therapies were selected for meta-analysis...
October 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28984385/antibiotic-resistance-of-helicobacter-pylori-to-16-antibiotics-in-clinical-patients
#14
Yongfu Shao, Rongdan Lu, Yunben Yang, Qiancheng Xu, Bojun Wang, Guoliang Ye
BACKGROUND: Resistance of Helicobacter pylori (H. pylori) to antibiotics is increasing worldwide. To determine the status of H. pylori resistance and its patterns in clinical patients, an investigation utilizing susceptibility testing for commonly used antibiotics was needed. METHODS: Total of 2283 H. pylori strains were collected from 2013 to 2016. The resistance and its patterns of these strains were tested by agar dilution method. The resistance rate and minimal inhibition concentration (MIC) in different gender groups were also analyzed...
October 6, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28983474/helicobacter-pylori-caga-protein-negatively-regulates-autophagy-and-promotes-inflammatory-response-via-c-met-pi3k-akt-mtor-signaling-pathway
#15
Na Li, Bin Tang, Yin-Ping Jia, Pan Zhu, Yuan Zhuang, Yao Fang, Qian Li, Kun Wang, Wei-Jun Zhang, Gang Guo, Tong-Jian Wang, You-Jun Feng, Bin Qiao, Xu-Hu Mao, Quan-Ming Zou
Cytotoxin-associated-gene A (CagA) of Helicobacter pylori (H. pylori) is a virulence factor that plays critical roles in H. pylori-induced gastric inflammation. In the present study, gastric biopsies were used for genotyping cagA and vacA genes, determining the autophagic activity, and the severity of gastric inflammation response. It was revealed that autophagy in gastric mucosal tissues infected with cagA(+)H. pylori strains was lower than the levels produced by cagA(-)H. pylori strains, accompanied with accumulation of SQSTM1 and decreased LAMP1 expression...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28980734/are-optic-nerve-heads-of-patients-with-helicobacter-pylori-infection-more-susceptible-to-glaucomatous-damage
#16
Cemile Ucgul Atilgan, Pinar Kosekahya, Ahmet Yozgat, Emine Sen, Nilufer Berker, Mehtap Caglayan, Selam Yekta Sendul, Emin Altiparmak, Pelin Yilmazbas
BACKGROUND: To compare retinal nerve fiber layer thicknesses (RNFLT) of patients with or without Helicobacter pylori infection and to reveal the possible RNFLT changes after H. pylori eradication. MATERIALS AND METHODS: Sixty-five eyes of 65 patients that tested positive for H. pylori (Group 1) and 48 eyes of 48 patients that tested negative for H. pylori (Group 2) were included. RNFLT analyses were performed with spectral-domain (SD) optical coherence tomography (OCT) in a total of five regions: the superior, inferior, nasal, and temporal quadrants and the average...
October 5, 2017: Helicobacter
https://www.readbyqxmd.com/read/28978882/a-case-of-gastric-perforation-caused-by-chestnut-bezoars
#17
Yutaka Okagawa, Kohichi Takada, Yohei Arihara, Junji Kato
A 65-year-old man was admitted under emergency to our hospital because of abdominal pain. His current medication history did not include steroids or nonsteroidal antiinflammatory drugs. He had taken an eradication agent for Helicobacter pylori, and his serum was negative for H. pylori IgG antibody. Abdominal computed tomography indicated gastric perforation;therefore, emergency surgery was performed. Two weeks later, esophagogastroduodenoscopy revealed a gastric ulcer on the lesser curvature of the gastric angle and bezoars...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28978808/monoclonal-igg-in-mgus-and-multiple-myeloma-targets-infectious-pathogens
#18
Adrien Bosseboeuf, Delphine Feron, Anne Tallet, Cédric Rossi, Cathy Charlier, Laurent Garderet, Denis Caillot, Philippe Moreau, Marina Cardó-Vila, Renata Pasqualini, Wadih Arap, Alfreda Destea Nelson, Bridget S Wilson, Hélène Perreault, Eric Piver, Pierre Weigel, François Girodon, Jean Harb, Edith Bigot-Corbel, Sylvie Hermouet
Subsets of mature B cell neoplasms are linked to infection with intracellular pathogens such as Epstein-Barr virus (EBV), hepatitis C virus (HCV), or Helicobacter pylori. However, the association between infection and the immunoglobulin-secreting (Ig-secreting) B proliferative disorders remains largely unresolved. We investigated whether the monoclonal IgG (mc IgG) produced by patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM) targets infectious pathogens...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28978104/the-influence-of-adjuvant-on-ureb-protection-against-helicobacter-pylori-through-the-diversity-of-cd4-t-cell-epitope-repertoire
#19
Bin Li, Hanmei Yuan, Li Chen, Heqiang Sun, Jian Hu, Shanshan Wei, Zhuo Zhao, Quanming Zou, Chao Wu
Adjuvants are widely used to enhance the effects of vaccines against pathogen infections. Interestingly, different adjuvants and vaccination routes usually induce dissimilar immune responses, and can even have completely opposite effects. The mechanism remains unclear. In this study, urease B subunit (UreB), an antigen of Helicobacter pylori (H. pylori) that can induce protective immune responses, was used as a model to vaccinate mice. We investigated the effects of different adjuvants and routes on consequent T cell epitope-specific targeting and protection against H...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977484/estimation-of-lifetime-cumulative-incidence-and-mortality-risk-of-gastric-cancer
#20
Yukari Taniyama, Kota Katanoda, Hadrien Charvat, Megumi Hori, Yuko Ohno, Shizuka Sasazuki, Shoichiro Tsugane
Objective: To estimate cumulative incidence and mortality risk for gastric cancer by risk category. Methods: Risk was classified into four types according to the presence/absence of Helicobacter pylori infection and chronic atrophic gastritis: in order of lowest to highest risk, Group A: H. pylori(-) and atrophic gastritis(-); Group B: H. pylori(+) and atrophic gastritis(-); Group C:H. pylori(+) and atrophic gastritis(+); and, Group D: H. pylori(-) and atrophic gastritis(+)...
September 8, 2017: Japanese Journal of Clinical Oncology
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