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https://www.readbyqxmd.com/read/27906799/diet-and-stress-in-pediatric-eosinophilic-esophagitis
#1
Christine Case, Glenn T Furuta, Dan Atkins, Zhaozing Pan, Jane Robinson
Clinical experiences and recent studies suggest that Eosinophilic Esophagitis (EoE) has the potential to induce caregiver (CG) and child stress. The specific sources of CG EoE-related stress remain uncertain. To address this, we performed a survey of CGs and youth attending an EoE patient education symposium that measured potential stressful elements in their daily life. Our results indicated that CGs experienced most stress associated with purchasing, preparation and completion of meals. We conclude that providers should consider this in choosing therapeutic approaches for children with EoE...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27891227/society-for-immunotherapy-of-cancer-consensus-statement-on-immunotherapy-for-the-treatment-of-renal-cell-carcinoma
#2
Brian I Rini, David F McDermott, Hans Hammers, William Bro, Ronald M Bukowski, Bernard Faba, Jo Faba, Robert A Figlin, Thomas Hutson, Eric Jonasch, Richard W Joseph, Bradley C Leibovich, Thomas Olencki, Allan J Pantuck, David I Quinn, Virginia Seery, Martin H Voss, Christopher G Wood, Laura S Wood, Michael B Atkins
Immunotherapy has produced durable clinical benefit in patients with metastatic renal cell cancer (RCC). In the past, patients treated with interferon-alpha (IFN) and interleukin-2 (IL-2) have achieved complete responses, many of which have lasted for multiple decades. More recently, a large number of new agents have been approved for RCC, several of which attack tumor angiogenesis by inhibiting vascular endothelial growth factors (VEGF) and VEGF receptors (VEGFR), as well as tumor metabolism, inhibiting the mammalian target of rapamycin (mTOR)...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27891164/a-low-carbohydrate-high-fat-diet-decreases-lean-mass-and-impairs-cardiac-function-in-pair-fed-female-c57bl-6j-mice
#3
Jessica Nilsson, Madelene Ericsson, Masoumeh Motamedi Joibari, Fredrick Anderson, Leif Carlsson, Stefan K Nilsson, Anna Sjödin, Jonas Burén
BACKGROUND: Excess body fat is a major health issue and a risk factor for the development of numerous chronic diseases. Low-carbohydrate diets like the Atkins Diet are popular for rapid weight loss, but the long-term consequences remain the subject of debate. The Scandinavian low-carbohydrate high-fat (LCHF) diet, which has been popular in Scandinavian countries for about a decade, has very low carbohydrate content (~5 E %) but is rich in fat and includes a high proportion of saturated fatty acids...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27881738/human-selenoprotein-p-and-s-variant-mrnas-with-different-numbers-of-secis-elements-and-inferences-from-mutant-mice-of-the-roles-of-multiple-secis-elements
#4
Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T Howard, Mario Capecchi, Roderic Guigó, Raymond F Burk, John F Atkins
Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3' UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site just 3' of SECIS 2, two further sites were identified with one resulting in 10-25% of the mRNA lacking SECIS 2. To address function, mutant mice were generated with either SECIS 1 or SECIS 2 deleted or with the first UGA substituted with a serine codon...
November 2016: Open Biology
https://www.readbyqxmd.com/read/27875518/a-national-cluster-randomised-controlled-trial-to-examine-the-effect-of-enhanced-reminders-on-the-socioeconomic-gradient-in-uptake-in-bowel-cancer-screening
#5
Rosalind Raine, Sue M Moss, Christian von Wagner, Wendy Atkin, Ines Kralj Hans, Rosemary Howe, Francesca Solmi, Stephen Morris, Nicholas Counsell, Allan Hackshaw, Stephen Halloran, Graham Handley, Richard F Logan, Sandra Rainbow, Steve Smith, Julia Snowball, Helen Seaman, Mary Thomas, Samuel G Smith, Lesley M McGregor, Gemma Vart, Jane Wardle, Stephen W Duffy
BACKGROUND: The NHS Bowel Cancer Screening Programme in England offers biennial guaiac faecal occult blood testing (gFOBt). There is a socioeconomic gradient in participation and socioeconomically disadvantaged groups have worse colorectal cancer survival than more advantaged groups. We compared the effectiveness and cost of an enhanced reminder letter with the usual reminder letter on overall uptake of gFOBt and the socioeconomic gradient in uptake. METHODS: We enhanced the usual reminder by including a heading 'A reminder to you' and a short paragraph restating the offer of screening in simple language...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27874002/atomically-resolved-phase-transition-of-fullerene-cations-solvated-in-helium-droplets
#6
M Kuhn, M Renzler, J Postler, S Ralser, S Spieler, M Simpson, H Linnartz, A G G M Tielens, J Cami, A Mauracher, Y Wang, M Alcamí, F Martín, M K Beyer, R Wester, A Lindinger, P Scheier
Helium has a unique phase diagram and below 25 bar it does not form a solid even at the lowest temperatures. Electrostriction leads to the formation of a solid layer of helium around charged impurities at much lower pressures in liquid and superfluid helium. These so-called 'Atkins snowballs' have been investigated for several simple ions. Here we form HenC60(+) complexes with n exceeding 100 via electron ionization of helium nanodroplets doped with C60. Photofragmentation of these complexes is measured by merging a tunable narrow-bandwidth laser beam with the ions...
November 22, 2016: Nature Communications
https://www.readbyqxmd.com/read/27870834/position-dependent-termination-and-widespread-obligatory-frameshifting-in-euplotes-translation
#7
Alexei V Lobanov, Stephen M Heaphy, Anton A Turanov, Maxim V Gerashchenko, Sandra Pucciarelli, Raghul R Devaraj, Fang Xie, Vladislav A Petyuk, Richard D Smith, Lawrence A Klobutcher, John F Atkins, Cristina Miceli, Dolph L Hatfield, Pavel V Baranov, Vadim N Gladyshev
The ribosome can change its reading frame during translation in a process known as programmed ribosomal frameshifting. These rare events are supported by complex mRNA signals. However, we found that the ciliates Euplotes crassus and Euplotes focardii exhibit widespread frameshifting at stop codons. 47 different codons preceding stop signals resulted in either +1 or +2 frameshifts, and +1 frameshifting at AAA was the most frequent. The frameshifts showed unusual plasticity and rapid evolution, and had little influence on translation rates...
November 21, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27865798/adoptive-transfer-of-ex%C3%A2-vivo-expanded-v%C3%AE-9v%C3%AE-2-t-cells-in-combination-with-zoledronic-acid-inhibits-cancer-growth-and-limits-osteolysis-in-a-murine-model-of-osteolytic-breast-cancer
#8
Aneta Zysk, Mark O DeNichilo, Vasilios Panagopoulos, Irene Zinonos, Vasilios Liapis, Shelley Hay, Wendy Ingman, Vladimir Ponomarev, Gerald Atkins, David Findlay, Andrew Zannettino, Andreas Evdokiou
Bone metastases occur in over 75% of patients with advanced breast cancer and are responsible for high levels of morbidity and mortality. In this study, ex vivo expanded cytotoxic Vγ9Vδ2 T cells isolated from human peripheral blood were tested for their anti-cancer efficacy in combination with zoledronic acid (ZOL), using a mouse model of osteolytic breast cancer. In vitro, expanded Vγ9Vδ2 T cells were cytotoxic against a panel of human breast cancer cell lines, and ZOL pre-treatment further sensitised breast cancer cells to killing by Vγ9Vδ2 T cells...
November 16, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27860148/a-review-of-rapid-access-cardiology-services-can-these-reduce-the-burden-of-acute-chest-pain-on-australian-and-new-zealand-health-services
#9
REVIEW
Harry Klimis, Aravinda Thiagalingam, Mikhail Altman, Emily Atkins, Gemma Figtree, Harry Lowe, N Wah Cheung, Pramesh Kovoor, A Robert Denniss, Clara K Chow
Chest pain is common and places a significant burden on hospital resources. Many patients with undifferentiated low to intermediate risk chest pain are admitted to hospital. Rapid Access Cardiology (RAC) services are hospital co-located cardiologist-led outpatient clinics that provide rapid assessment and immediate management but not long term management. This service model is described as part of chest pain management and the National Service Framework for coronary heart disease in the United Kingdom (UK)...
November 16, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27859952/strong-thermal-acclimation-of-photosynthesis-in-tropical-and-temperate-wet-forest-tree-species-the-importance-of-altered-rubisco-content
#10
Andrew P Scafaro, Shuang Xiang, Benedict M Long, Nur H A Bahar, Lasantha K Weerasinghe, Danielle Creek, John R Evans, Peter B Reich, Owen K Atkin
Understanding of the extent of acclimation of light-saturated net photosynthesis (An ) to temperature (T), and associated underlying mechanisms, remains limited. This is a key knowledge gap given the importance of thermal acclimation for plant functioning, both under current and future higher temperatures, limiting the accuracy and realism of Earth System Model (ESM) predictions. Given this, we analysed and modelled T-dependent changes in photosynthetic capacity in 10 wet-forest tree species; six from temperate forests and four from tropical forests...
November 16, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27856338/sedentary-behaviour-across-the-primary-secondary-school-transition-a-systematic-review
#11
REVIEW
Natalie Pearson, Emma Haycraft, Julie P Johnston, Andrew J Atkin
The transition from primary/middle school to secondary/high school is likely to be a key period in children's development, characterised by significant changes in their social and physical environment. However, little is known about the changes in sedentary behaviour that accompany this transition. This review aimed to identify, critically appraise and summarise the evidence on changes in sedentary behaviour across the primary - secondary school transition. Published English language studies were located from computerised and manual searches in 2015...
November 14, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27855987/simulations-of-morphotype-dependent-hemodynamics-in-non-dilated-bicuspid-aortic-valve-aortas
#12
Kai Cao, Samantha K Atkins, Andrew McNally, Janet Liu, Philippe Sucosky
Bicuspid aortic valves (BAVs) generate flow abnormalities that may promote aortopathy. While positive helix fraction (PHF) index, flow angle (θ), flow displacement (d) and wall shear stress (WSS) exhibit abnormalities in dilated BAV aortas, it is unclear whether those anomalies stem from the abnormal valve anatomy or the dilated aorta. Therefore, the objective of this study was to quantify the early impact of different BAV morphotypes on aorta hemodynamics prior to dilation. Fluid-structure interaction models were designed to quantify standard peak-systolic flow metrics and temporal WSS characteristics in a realistic non-dilated aorta connected to functional tricuspid aortic valve (TAV) and type-I BAVs...
November 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27855768/-cognitive-deficits-are-underestimated-in-children-with-benign-epilepsy-with-centro-temporal-spikes
#13
Mary Doreen Atkins, Kirsten Juul
Benign epilepsy with centro-temporal spikes (BECTS) is, as the name suggests, usually considered benign. However, there is a growing awareness that this is not the case in all instances. Many of the children with BECTS have neuropsychological and linguistic dysfunctions, even after remission of the disease. In patients with classic BECTS, an association with GRIN2A-mutations is reported by several groups, suggesting a possible placement of BECTS at the mild end of an epileptic-aphasia spectrum. Awareness of the possible neuropsychological consequences of BECTS should be considered when treating these children...
November 7, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27852456/implementing-cardiopulmonary-resuscitation-training-programs-in-high-schools-iowa-s-experience
#14
Derek B Hoyme, Dianne L Atkins
OBJECTIVE: To understand perceived barriers to providing cardiopulmonary resuscitation (CPR) education, implementation processes, and practices in high schools. STUDY DESIGN: Iowa has required CPR as a graduation requirement since 2011 as an unfunded mandate. A cross-sectional study was performed through multiple choice surveys sent to Iowa high schools to collect data about school demographics, details of CPR programs, cost, logistics, and barriers to implementation, as well as automated external defibrillator training and availability...
November 14, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27843758/frequency-and-duration-of-physical-activity-bouts-in-school-aged-children-a-comparison-within-and-between-days
#15
Hannah L Brooke, Andrew J Atkin, Kirsten Corder, Soren Brage, Esther Mf van Sluijs
Understanding how physical activity (PA) patterns vary within and between days may guide PA promotion in young people. We aimed to 1) describe and compare the frequency (bouts/day) and duration (min/bout) of bouts of moderate-to-vigorous intensity PA (MVPA) on weekdays vs. weekends and in-school vs. out-of-school, and 2) assess associations of bout frequency and duration in these time-segments with overall PA. We used cross-sectional accelerometer data from 2737 children (aged 6-19 years) in the United States National Health and Nutrition Examination Survey (NHANES) 2003-2006...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27842597/community-engagement-to-enhance-trust-between-gypsy-travellers-and-maternity-early-years-and-child-dental-health-services-protocol-for-a-multi-method-exploratory-study
#16
Alison McFadden, Karl Atkin, Kerry Bell, Nicola Innes, Cath Jackson, Helen Jones, Steve MacGillivray, Lindsay Siebelt
BACKGROUND: Gypsy/Travellers have poor health and experience discrimination alongside structural and cultural barriers when accessing health services and consequently may mistrust those services. Our study aims to investigate which approaches to community engagement are most likely to be effective at enhancing trust between Gypsy/Travellers and mainstream health services. METHODS: This multi-method 30-month study, commenced in June 2015, and comprises four stages...
November 14, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27836774/peroxidase-enzymes-inhibit-osteoclast-differentiation-and-bone-resorption
#17
Vasilios Panagopoulos, Vasilios Liapis, Irene Zinonos, Shelley Hay, Damien A Leach, Wendy Ingman, Mark O DeNichilo, Gerald J Atkins, David M Findlay, Andrew C W Zannettino, Andreas Evdokiou
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are heme-containing enzymes, well known for their antimicrobial activity, are released in abundance by innate immune infiltrates at sites of inflammation and injury. We have discovered new and previously unrecognised roles for heme peroxidases in extracellular matrix biosynthesis, angiogenesis, and bone mineralisation, all of which play an essential role in skeletal integrity. In this study we used in vitro models of osteoclastogenesis to investigate the effects of heme peroxidase enzymes on osteoclast differentiation and bone resorbing activity, pertinent to skeletal development and remodelling...
November 9, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27835065/sustained-delivery-of-timolol-maleate-for-over-90-days-by-subconjunctival-injection
#18
Erin Lavik, Markus H Kuehn, Andrew J Shoffstall, Kristyn Atkins, Alina V Dumitrescu, Young H Kwon
PURPOSE: Medical treatment of glaucoma relies on intraocular pressure (IOP)-lowering medications, typically administered daily by the patient. While these medications are effective when applied correctly, patient adherence is a major obstacle in glaucoma treatment. We have developed a sustained-release formulation of timolol maleate that can be injected subconjunctivally to avoid patient noncompliance. METHODS: A biodegradable microsphere formulation for timolol maleate was injected subconjunctivally in normal rabbits...
November 11, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27834531/autolysis-mechanisms-of-action-in-the-removal-of-devitalised-tissue
#19
Leanne Atkin, Mark Rippon
Chronic wounds affect millions of people worldwide. In the UK alone, the cost of their treatment is estimated to be between £4.5bn and £5.1bn. The implementation of wound-bed preparation strategies remove the barriers to healing and wound debridement is a key component in preparing the wound bed for wound progression. This article aims to review one of the several debridement methods available to clinicians: autolytic debridement. Autolysis (i.e. autolytic debridement) uses the body's own enzymatic mechanisms to remove devitalised tissue in order to remove the barriers to healing...
November 10, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27827836/3d-buried-utility-location-using-a-marching-cross-section-algorithm-for-multi-sensor-data-fusion
#20
Qingxu Dou, Lijun Wei, Derek R Magee, Phil R Atkins, David N Chapman, Giulio Curioni, Kevin F Goddard, Farzad Hayati, Hugo Jenks, Nicole Metje, Jennifer Muggleton, Steve R Pennock, Emiliano Rustighi, Steven G Swingler, Christopher D F Rogers, Anthony G Cohn
We address the problem of accurately locating buried utility segments by fusing data from multiple sensors using a novel Marching-Cross-Section (MCS) algorithm. Five types of sensors are used in this work: Ground Penetrating Radar (GPR), Passive Magnetic Fields (PMF), Magnetic Gradiometer (MG), Low Frequency Electromagnetic Fields (LFEM) and Vibro-Acoustics (VA). As part of the MCS algorithm, a novel formulation of the extended Kalman Filter (EKF) is proposed for marching existing utility tracks from a scan cross-section (scs) to the next one; novel rules for initializing utilities based on hypothesized detections on the first scs and for associating predicted utility tracks with hypothesized detections in the following scss are introduced...
November 2, 2016: Sensors
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