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https://www.readbyqxmd.com/read/29046197/-prospective-study-of-ketogenic-diet-in-treatment-of-children-with-global-developmental-delay
#1
Deng-Na Zhu, Ping Li, Jun Wang, Jun-Ying Yuan, Guang-Yu Zhang, Jiang-Fang Liang, Ming-Mei Wang, Yun-Xia Zhao, Shuang An, Na Ma, Dan-Dan Ma
OBJECTIVE: To study the effect of ketogenic diet (KD) on neurobehavioral development, emotional and social behaviors, and life ability in children with global developmental delay (GDD). METHODS: A prospective case-control study was performed for hospitalized children with GDD, who were randomly divided into KD treatment group (n=40) and conventional treatment group (n=37). The children in both groups were given comprehensive rehabilitation training, and those in the KD treatment group were given modified Atkins diet in addition to the comprehensive rehabilitation training...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29045121/wafer-scale-synthesis-of-semiconducting-sno-monolayers-from-interfacial-oxide-layers-of-metallic-liquid-tin
#2
Torben Daeneke, Paul Atkin, Rebecca Orrell-Trigg, Ali Zavabeti, Taimur Ahmed, Sumeet Walia, Maning Liu, Yasuhiro Tachibana, Maria Javaid, Andrew D Greentree, Salvy P Russo, Richard B Kaner, Kourosh Kalantar-Zadeh
Atomically thin semiconductors are one of the fastest growing categories in materials science due to their promise to enable high-performance electronic and optical devices. Furthermore, a host of intriguing phenomena have been reported to occur when a semiconductor is confined within two dimensions. However, the synthesis of large area atomically thin materials remains as a significant technological challenge. Here we report a method that allows harvesting monolayer of semiconducting stannous oxide nanosheets (SnO) from the interfacial oxide layer of liquid tin...
October 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/29041898/societal-preferences-for-adjuvant-melanoma-health-states-uk-and-australia
#3
Mark R Middleton, Michael B Atkins, Kaitlan Amos, Peter Feng Wang, Srividya Kotapati, Javier Sabater, Kathleen Beusterien
BACKGROUND: No studies have measured preference-based utility weights for specific toxicities and outcomes associated with approved and investigational adjuvant treatments for patients with resected high-risk melanoma. METHODS: A cross-sectional study was conducted in the United Kingdom and Australia to obtain utilities for 14 adjuvant melanoma health states. One-on-one interviews were conducted using standard gamble; utility weights range from 0.0, dead, to 1.0, full health...
October 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29040042/mental-health-first-aid-a-useful-tool-for-school-nurses
#4
Joy Atkins
School nurses address mental health issues of youth on a daily basis. These mental health issues include substance abuse, anxiety, depression, and even suicidal ideation. Mental health first aid is a process that seeks to help medical professionals and laypeople recognize and address someone that is having a mental health or substance abuse crisis. This article will describe an experience with a student having suicidal ideations and how the mental health action plan was used.
November 2017: NASN School Nurse
https://www.readbyqxmd.com/read/29040030/nivolumab-plus-ipilimumab-in-patients-with-advanced-melanoma-updated-survival-response-and-safety-data-in-a-phase-i-dose-escalation-study
#5
Margaret K Callahan, Harriet Kluger, Michael A Postow, Neil H Segal, Alexander Lesokhin, Michael B Atkins, John M Kirkwood, Suba Krishnan, Rafia Bhore, Christine Horak, Jedd D Wolchok, Mario Sznol
Purpose The clinical activity observed in a phase I dose-escalation study of concurrent therapy with nivolumab (NIVO) and ipilimumab (IPI) in patients with previously treated or untreated advanced melanoma led to subsequent clinical development, including randomized trials. Here, we report long-term follow-up data from study CA209-004, including 3-year overall survival (OS). Patients and Methods Concurrent cohorts 1, 2, 2a, and 3 received escalating doses of NIVO plus IPI once every 3 weeks for four doses, followed by NIVO once every 3 weeks for four doses, then NIVO plus IPI once every 12 weeks for eight doses...
October 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29038463/ncor1-restrains-thymic-negative-selection-by-repressing-bim-expression-to-spare-thymocytes-undergoing-positive-selection
#6
Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T Yu, Annette R Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M Evans, Qibin Leng
Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation of thymocytes whose TCRs display intermediate affinity to self pMHCs for effective immunity, but whether transcriptional regulation helps conserve positively selected thymocytes from being purged by negative selection remains unclear...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29037253/asxl-gain-of-function-truncation-mutants-defective-and-dysregulated-forms-of-a-natural-ribosomal-frameshifting-product
#7
Adam M Dinan, John F Atkins, Andrew E Firth
BACKGROUND: Programmed ribosomal frameshifting (PRF) is a gene expression mechanism which enables the translation of two N-terminally coincident, C-terminally distinct protein products from a single mRNA. Many viruses utilize PRF to control or regulate gene expression, but very few phylogenetically conserved examples are known in vertebrate genes. Additional sex combs-like (ASXL) genes 1 and 2 encode important epigenetic and transcriptional regulatory proteins that control the expression of homeotic genes during key developmental stages...
October 16, 2017: Biology Direct
https://www.readbyqxmd.com/read/29034969/experience-with-mad-on-children-with-epilepsy-in-egypt-after-classic-kd-failure
#8
O F El Rashidy, M F Nassar, Y G El Gendy, S M Deifalla, S Gaballa
BACKGROUND AND AIM: Modified Atkins diet (MAD) is a less restrictive type of ketogenic diet (KD) as compared to the classic one. The aim of this study was to evaluate the impact of 9 months MAD treatment on the growth and seizure control in patients with intractable epilepsy as well as the quality of life (QoL) of their mothers. SUBJECTS AND METHODS: The study included 15 patients with intractable epilepsy who could not tolerate their classic KD management plan...
October 16, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29032767/metabonomics-uncovers-a-reversible-proatherogenic-lipid-profile-during-infliximab-therapy-of-inflammatory-bowel-disease
#9
Jacob Tveiten Bjerrum, Casper Steenholdt, Mark Ainsworth, Ole Haagen Nielsen, Michelle Ac Reed, Karen Atkins, Ulrich Leonhard Günther, Fuhua Hao, Yulan Wang
BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great clinical significance. This study employs spectroscopy-based metabolic profiling of serum from patients with IBD treated with IFX and healthy subjects (1) to substantiate the use of spectroscopy as a semi-invasive diagnostic tool, (2) to identify potential biomarkers of treatment response and (3) to characterise the metabolic changes during management of patients with tumour necrosis factor-α inhibitors...
October 16, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29032679/mapping-free-carriers-in-multijunction-silicon-nanowires-using-infrared-near-field-optical-microscopy
#10
Earl T Ritchie, David J Hill, Tucker M Mastin, Panfilo C Deguzman, James F Cahoon, Joanna M Atkin
We report the use of infrared (IR) scattering-type scanning near-field optical microscopy (s-SNOM) as a non-destructive method to map free-carriers in axially modulation-doped silicon nanowires (SiNWs) with nanoscale spatial resolution. Using this technique, we can detect local changes in the electrically-active doping concentration based on the infrared free-carrier response in SiNWs grown using the vapor-liquid-solid (VLS) method. We demonstrate that IR s-SNOM is sensitive to both p-type and n-type free-carriers, for carrier densities above ∼ 1 × 10(19) cm-3...
October 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29030907/macromolecular-rate-theory-mmrt-provides-a-thermodynamics-rationale-to-underpin-the-convergent-temperature-response-in-plant-leaf-respiration
#11
Liyin L Liang, Vickery L Arcus, Mary A Heskel, Odhran S O'Sullivan, Lasantha K Weerasinghe, Danielle Creek, John J G Egerton, Mark G Tjoelker, Owen K Atkin, Louis A Schipper
Temperature is a crucial factor in determining the rates of ecosystem processes, e.g. leaf respiration (R) - the flux of plant respired CO2 from leaves to the atmosphere. Generally, R increases exponentially with temperature and formulations such as the Arrhenius equation are widely used in earth system models. However, experimental observations have shown a consequential and consistent departure from an exponential increase in R. What are the principles that underlie these observed patterns? Here, we demonstrate that macromolecular rate theory (MMRT), based on transition state theory for enzyme-catalyzed kinetics, provides a thermodynamic explanation for the observed departure and the convergent temperature response of R using a global database...
October 14, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29030056/development-of-a-generic-wound-care-assessment-minimum-data-set
#12
Susanne Coleman, E Andrea Nelson, Peter Vowden, Kathryn Vowden, Una Adderley, Lesley Sunderland, Judy Harker, Tracy Conroy, Sarah Fiori, Nicola Bezer, Emma Holding, Leanne Atkin, Emma Stables, Jo Dumville, Sue Gavelle, Heidi Sandoz, Keith Moore, Tina Chambers, Sally Napper, Jane Nixon
BACKGROUND: At present there is no established national minimum data set (MDS) for generic wound assessment in England, which has led to a lack of standardisation and variable assessment criteria being used across the country. This hampers the quality and monitoring of wound healing progress and treatment. AIM: To establish a generic wound assessment MDS to underpin clinical practice. METHOD: The project comprised 1) a literature review to provide an overview of wound assessment best practice and identify potential assessment criteria for inclusion in the MDS and 2) a structured consensus study using an adapted Research and Development/University of California at Los Angeles Appropriateness method...
September 18, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29023307/interrater-agreement-of-eeg-interpretation-after-pediatric-cardiac-arrest-using-standardized-critical-care-eeg-terminology
#13
Nicholas S Abend, Shavonne L Massey, Mark Fitzgerald, France Fung, Natalie J Atkin, Rui Xiao, Alexis A Topjian
PURPOSE: We evaluated interrater agreement of EEG interpretation in a cohort of critically ill children resuscitated after cardiac arrest using standardized EEG terminology. METHODS: Four pediatric electroencephalographers scored 10-minute EEG segments from 72 consecutive children obtained 24 hours after return of circulation using the American Clinical Neurophysiology Society's (ACNS) Standardized Critical Care EEG terminology. The percent of perfect agreement and the kappa coefficient were calculated for each of the standardized EEG variables and a predetermined composite EEG background category...
October 10, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29022427/confirming-the-timing-of-phase-based-costing-in-oncology-studies-a-case-example-in-advanced-melanoma
#14
Michael Atkins, Anna D Coutinho, Sasikiran Nunna, Komal Gupte-Singh, Michael Eaddy
AIMS: The utilization of health care services and costs among patients with cancer is often estimated by the phase of care: initial, interim, or terminal. Although their durations are often set arbitrarily, we sought to establish data-driven phases of care using joinpoint regression in an advanced melanoma population as a case example. METHODS: A retrospective claims database study was conducted to assess the costs of advanced melanoma from distant metastasis diagnosis to death 01/2010-09/2014...
October 12, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29021214/casein-kinase-ii-phosphorylation-of-cyclin-f-at-serine-621-regulates-the-lys48-ubiquitylation-e3-ligase-activity-of-the-scf-cyclin-f-complex
#15
Albert Lee, Stephanie L Rayner, Alana De Luca, Serene S L Gwee, Marco Morsch, Vinod Sundaramoorthy, Hamideh Shahheydari, Audrey Ragagnin, Bingyang Shi, Shu Yang, Kelly L Williams, Emily K Don, Adam K Walker, Katharine Y Zhang, Justin J Yerbury, Nicholas J Cole, Julie D Atkin, Ian P Blair, Mark P Molloy, Roger S Chung
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3-5 years of diagnosis. Recently, we identified disease-linked mutations in the CCNF gene, which encodes the cyclin F protein, in cohorts of patients with familial and sporadic ALS and frontotemporal dementia (FTD) (Williams KL et al 2016 Nat. Commun.7, 11253. (doi:10.1038/ncomms11253)). Cyclin F is a part of a Skp1-Cul-F-box (SCF) E3 ubiquitin-protein ligase complex and is responsible for ubiquitylating proteins for degradation by the proteasome...
October 2017: Open Biology
https://www.readbyqxmd.com/read/29018156/the-effect-of-atorvastatin-on-pancreatic-beta-cell-requirement-in-women-with-polycystic-ovary-syndrome
#16
Thozhukat Sathyapalan, Anne-Marie Coady, Eric Kilpatrick, Stephen Atkin
BACKGROUND: There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients. However, there is some data to show that statins increase the risk of incipient diabetes. MATERIAL AND METHODS: We have previously shown that 12-weeks of atorvastatin improves insulin resistance when measured using HOMA-IR. This post hoc-analysis was designed to look at the effect of atorvastatin on pancreatic β cell function using HOMA-β in the same study...
October 10, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28994212/high-frequency-of-brain-metastases-after-adjuvant-therapy-for-high-risk-melanoma
#17
Wolfram E Samlowski, James Moon, Merle Witter, Michael B Atkins, John M Kirkwood, Megan Othus, Antoni Ribas, Vernon K Sondak, Lawrence E Flaherty
The incidence of CNS progression in patients with high-risk regional melanoma (stages IIIAN2a-IIIC) is not well characterized. Data from the S0008 trial provided an opportunity to examine the role of CNS progression in treatment failure and survival. All patients were surgically staged. Following wide excision and full regional lymphadenectomy, patients were randomized to receive adjuvant biochemotherapy (BCT) or high-dose interferon alfa-2B (HDI). CNS progression was retrospectively identified from data forms...
October 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28988455/safety-profiles-of-percutaneous-left-atrial-appendage-closure-devices-an-analysis-of-the-food-and-drug-administration-manufacturer-and-user-facility-device-experience-maude-database-from-2009-2016
#18
Mohammad-Ali Jazayeri, Venkat Vuddanda, Mohit K Turagam, Valay Parikh, Madhav Lavu, Donita Atkins, Matthew Earnest, Luigi Di Biase, Andrea Natale, David Wilber, Yeruva Madhu Reddy, Dhanunjaya Lakkireddy
BACKGROUND: Percutaneous left atrial appendage closure (LAAC) is a viable option for AF patients who are unable to tolerate long term oral anticoagulation (OAC). OBJECTIVE: We sought to assess the safety of two commonly used percutaneous devices for LAA closure in the United States by analysis of surveillance data from the FDA Manufacturer and User Facility Device Experience (MAUDE) database. METHODS: The MAUDE database was queried between May 1, 2006 and May 1, 2016 for LARIAT® (SentreHEART Inc...
October 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28986500/surveillance-in-scotland-and-northern-ireland-how-do-you-engage
#19
Hayley Atkin
Hayley Atkin, BVA policy officer, encourages vets in Scotland and Northern Ireland to help BVA understand how they engage with veterinary surveillance.
October 7, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28984911/a-molecular-approach-to-drought-induced-reduction-in-leaf-co2-exchange-in-drought-resistant-quercus-ilex
#20
Jesús Rodríguez-Calcerrada, Ana Margarida Rodrigues, Pedro Perdiguero, Carla António, Owen K Atkin, Meng Li, Carmen Collada, Luis Gil
Drought-induced reduction of leaf gas exchange entails a complex regulation of the plant leaf metabolism. We used a combined molecular and physiological approach to understand leaf photosynthetic and respiratory responses of two-year-old Quercus ilex seedlings to drought. Mild drought stress resulted in glucose accumulation while net photosynthetic CO2 uptake (Pn ) remained unchanged, suggesting a role of glucose in stress signaling and/or osmoregulation. Simple sugars and sugar alcohols increased throughout moderate to very severe drought stress conditions, in parallel to a progressive decline in Pn and the quantum efficiency of photosystem II; by contrast, minor changes occurred in respiration rates until drought stress was very severe...
October 6, 2017: Physiologia Plantarum
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