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https://www.readbyqxmd.com/read/28647512/effect-of-dipeptidyl-peptidase-4-inhibitors-on-circulating-tumor-necrosis-factor-%C3%AE-concentrations-a-systematic-review-and-meta-analysis-of-controlled-trials
#1
REVIEW
Stephen L Atkin, Niki Katsiki, Maciej Banach, Dimitri P Mikhailidis, Matteo Pirro, Amirhossein Sahebkar
OBJECTIVE: Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes mellitus. There are also reports of an effect of these drugs in reducing inflammation through inhibition of tumor necrosis factor-α (TNF-α) that is an important mediator for several inflammatory processes. The present systematic review and meta-analysis were performed to evaluate the effect of DPP-4 inhibitors on circulating TNF-α levels in T2DM patients. METHODS: A systematic review and a meta-analysis were undertaken on all controlled trials of DPP-4 inhibitors that included measurement of TNF-α...
June 3, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28640201/deoxynivalenol-biomarkers-in-the-urine-of-uk-vegetarians
#2
Liz Wells, Laura Hardie, Courtney Williams, Kay White, Yunru Liu, Barbara De Santis, Francesca Debegnach, Georgio Moretti, Stephanie Greetham, Carlo Brera, Maria Papageorgiou, Natalie J Thatcher, Alan Rigby, Stephen L Atkin, Thozhukat Sathyapalan
Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycotoxin. This study provides the levels of DON and de-epoxi Deoxynivalenol (DOM-1) in urine analysed by liquid chromatography-mass spectrometry (LC-MS) in UK vegetarians. Over two consecutive days, morning urine samples were collected from 32 vegetarians and 31 UK adult volunteers, and associated food consumption 24 h prior to the sample was recorded...
June 22, 2017: Toxins
https://www.readbyqxmd.com/read/28639815/a-multivariate-meta-analysis-of-motivational-interviewing-process-and-outcome
#3
Brian T Pace, Aaron Dembe, Christina S Soma, Scott A Baldwin, David C Atkins, Zac E Imel
Motivational interviewing (MI) theory proposes a process whereby a set of therapist behaviors has direct effects on client outcomes and indirect effects through in-session processes (e.g., client change talk). Despite clear empirical support for the efficacy of MI across settings, the results of studies evaluating proposed links between MI process and outcome have been less clear. In the present study, we used a series of multivariate meta-analyses to test whether there are differential relationships between specific MI-consistent and MI-inconsistent therapist behaviors, MI therapist global ratings, client change language, and clinical outcomes...
June 22, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28637486/a-guide-to-using-the-theoretical-domains-framework-of-behaviour-change-to-investigate-implementation-problems
#4
Lou Atkins, Jill Francis, Rafat Islam, Denise O'Connor, Andrea Patey, Noah Ivers, Robbie Foy, Eilidh M Duncan, Heather Colquhoun, Jeremy M Grimshaw, Rebecca Lawton, Susan Michie
BACKGROUND: Implementing new practices requires changes in the behaviour of relevant actors, and this is facilitated by understanding of the determinants of current and desired behaviours. The Theoretical Domains Framework (TDF) was developed by a collaboration of behavioural scientists and implementation researchers who identified theories relevant to implementation and grouped constructs from these theories into domains. The collaboration aimed to provide a comprehensive, theory-informed approach to identify determinants of behaviour...
June 21, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28636694/placebo-response-and-practice-effects-in-schizophrenia-cognition-trials
#5
Richard S E Keefe, Vicki G Davis, Philip D Harvey, Alexandra S Atkins, George M Haig, Owen Hagino, Stephen Marder, Dana C Hilt, Daniel Umbricht
Importance: Patients' previous experience with performance-based cognitive tests in clinical trials for cognitive impairment associated with schizophrenia can create practice-related improvements. Placebo-controlled trials for cognitive impairment associated with schizophrenia are at risk for these practice effects, which can be difficult to distinguish from placebo effects. Objectives: To conduct a systematic evaluation of the magnitude of practice effects on the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB) in cognitive impairment associated with schizophrenia and to examine which demographic, clinical, and cognitive characteristics were associated with improvement in placebo conditions...
June 21, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28632865/effect-of-first-line-chemotherapy-combined-with-cetuximab-or-bevacizumab-on-overall-survival-in-patients-with-kras-wild-type-advanced-or-metastatic-colorectal-cancer-a-randomized-clinical-trial
#6
Alan P Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Briant Fruth, Jeffrey A Meyerhardt, Deborah Schrag, Claire Greene, Bert H O'Neil, James Norman Atkins, Scott Berry, Blase N Polite, Eileen M O'Reilly, Richard M Goldberg, Howard S Hochster, Richard L Schilsky, Monica M Bertagnolli, Anthony B El-Khoueiry, Peter Watson, Al B Benson, Daniel L Mulkerin, Robert J Mayer, Charles Blanke
Importance: Combining biologic monoclonal antibodies with chemotherapeutic cytotoxic drugs provides clinical benefit to patients with advanced or metastatic colorectal cancer, but the optimal choice of the initial biologic therapy in previously untreated patients is unknown. Objective: To determine if the addition of cetuximab vs bevacizumab to the combination of leucovorin, fluorouracil, and oxaliplatin (mFOLFOX6) regimen or the combination of leucovorin, fluorouracil, and irinotecan (FOLFIRI) regimen is superior as first-line therapy in advanced or metastatic KRAS wild-type (wt) colorectal cancer...
June 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28627891/effect-of-deep-eutectic-solvent-nanostructure-on-phospholipid-bilayer-phases
#7
Saffron Jade Bryant, Rob Atkin, Gregory G Warr
Phospholipids are shown by solvent penetration experiments to form lamellar phases and spontaneously spawn vesicles in a wide range of deep eutectic solvents (DESs) composed of alkylammonium halide salts and glycerol or ethylene glycol, which are shown to be nanostructured by X-ray scattering. In contrast with molecular solvents, the chain melting temperature of each phospholipid, which determines the stability of the swellable bilayer phase, depends on the structure of the cation, anion and molecular H-bond donor that constitute the DES...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28624892/a-meta-analysis-of-manual-versus-remote-magnetic-navigation-for-ventricular-tachycardia-ablation
#8
Mohit K Turagam, Donita Atkins, Roderick Tung, Moussa Mansour, Jeremy Ruskin, Jie Cheng, Luigi Di Biase, Andrea Natale, Dhanunjaya Lakkireddy
BACKGROUND: There are limited studies on the safety and efficacy of remote magnetic navigation (RMN) versus manual navigation (MAN) in ventricular tachycardia (VT) ablation. METHODS: A comprehensive literature search was performed using the keywords VT ablation, stereotaxis, RMN and MAN in Pubmed, Ebsco, Web of Science, Cochrane, and Google scholar databases. RESULTS: The analysis included seven studies (one randomized, three prospective observational, and three retrospective) including 779 patients [both structural heart disease (SHD) and idiopathic VT] comparing RMN (N = 433) and MAN (N = 339) in VT ablation...
June 17, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28621643/the-clinical-effectiveness-of-different-surveillance-strategies-to-prevent-colorectal-cancer-in-people-with-intermediate-grade-colorectal-adenomas-a-retrospective-cohort-analysis-and-psychological-and-economic-evaluations
#9
Wendy Atkin, Amy Brenner, Jessica Martin, Katherine Wooldrage, Urvi Shah, Fiona Lucas, Paul Greliak, Kevin Pack, Ines Kralj-Hans, Ann Thomson, Sajith Perera, Jill Wood, Anne Miles, Jane Wardle, Benjamin Kearns, Paul Tappenden, Jonathan Myles, Andrew Veitch, Stephen W Duffy
BACKGROUND: The UK guideline recommends 3-yearly surveillance for patients with intermediate-risk (IR) adenomas. No study has examined whether or not this group has heterogeneity in surveillance needs. OBJECTIVES: To examine the effect of surveillance on colorectal cancer (CRC) incidence; assess heterogeneity in risk; and identify the optimum frequency of surveillance, the psychological impact of surveillance, and the cost-effectiveness of alternative follow-up strategies...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28620242/salivary-testosterone-measurement-in-women-with-and-without-polycystic-ovary-syndrome
#10
Thozhukat Sathyapalan, Ahmed Al-Qaissi, Eric S Kilpatrick, Soha R Dargham, Joanne Adaway, Brian Keevil, Stephen L Atkin
Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P < 001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI) (p < 0...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28618040/optimising-implementation-of-a-patient-assessment-framework-for-emergency-nurses-a-mixed-method-study
#11
Belinda Munroe, Kate Curtis, Thomas Buckley, Melinda Lewis, Lou Atkins
AIMS AND OBJECTIVES: To determine potential facilitators and barriers and tailor interventions to optimise future implementation of a patient-assessment framework into emergency nursing practice. BACKGROUND: An evidence-informed patient-assessment framework HIRAID (History, Identify Red flags, Assessment, Interventions, Diagnostics, communication and reassessment) improves the quality of patient assessments performed by emergency nurses. Facilitators and barriers must be understood and tailored interventions selected to optimise implementation...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28617152/impact-of-immunoablation-and-autologous-hematopoietic-stem-cell-transplantation-on-gray-and-white-matter-atrophy-in-multiple-sclerosis
#12
Hyunwoo Lee, Kunio Nakamura, Sridar Narayanan, Robert Brown, Jacqueline Chen, Harold L Atkins, Mark S Freedman, Douglas L Arnold
BACKGROUND: Immunoablation and autologous hematopoietic stem cell transplantation (IA/aHSCT) halts relapses, white matter (WM) lesion formation, and pathological whole-brain (WB) atrophy in multiple sclerosis (MS) patients. Whether the latter was due to effects on gray matter (GM) or WM warranted further exploration. OBJECTIVE: To model GM and WM volume changes after IA/aHSCT to further understand the effects seen on WB atrophy. METHODS: GM and WM volume changes were calculated from serial baseline and follow-up magnetic resonance imaging (MRI) ranging from 1...
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28615345/variation-in-leaf-respiration-rates-at-night-correlate-with-carbohydrate-and-amino-acid-supply
#13
Brendan M O'Leary, Chun Pong Lee, Owen K Atkin, Riyan Cheng, Tim B Brown, A Harvey Millar
Plant respiration can theoretically be fuelled by and dependent upon an array of central metabolism components; however, which ones are responsible for the quantitative variation found in respiratory rates is unknown. Here, large scale screens revealed twofold variation in night-time leaf respiration rate (RN) among mature leaves from an Arabidopsis natural accession collection grown under common favourable conditions. RN variation was mostly maintained in the absence of genetic variation, which emphasized the low heritability of RN and its plasticity towards relatively small environmental differences within the sampling regime...
June 14, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28612609/surface-water-dependent-properties-of-sulfur-rich-molybdenum-sulfides-electrolyteless-gas-phase-water-splitting
#14
Torben Daeneke, Nripen Dahr, Paul Atkin, Rhiannon M Clark, Christopher J Harrison, Robert Brkljača, Naresh Pillai, Bao Yue Zhang, Ali Zavabeti, Samuel J Ippolito, Kyle J Berean, Jian Zhen Ou, Michael S Strano, Kourosh Kalantar-Zadeh
Sulfur-rich molybdenum sulfides are an emerging class of inorganic coordination polymers that are predominantly utilized for their superior catalytic properties. Here we investigate surface water dependent properties of sulfur-rich MoSx (x = 3(2)/3) and its interaction with water vapor. We report that MoSx is a highly hygroscopic semiconductor, which can reversibly bind up to 0.9 H2O molecule per Mo. The presence of surface water is found to have a profound influence on the semiconductor's properties, modulating the material's photoluminescence by over 1 order of magnitude, in transition from dry to moist ambient...
June 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28609140/lipid-lowering-activity-of-artichoke-extracts-a-systematic-review-and-meta-analysis
#15
Amirhossein Sahebkar, Matteo Pirro, Maciej Banach, Dimitri P Mikhailidis, Stephen L Atkin, Arrigo F G Cicero
Artichoke is a component of the Mediterranean diet. Therefore, the aim of this meta-analysis was to determine if artichoke extract supplementation affected human lipid parameters. The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, to identify RCTs investigating the impact of artichoke extracts on plasma lipid levels. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28608688/dichotomous-well-defined-nanostructure-with-weakly-arranged-ion-packing-explains-the-solvency-of-pyrrolidinium-acetate
#16
Haihui Joy Jiang, Silvia Imberti, Rob Atkin, Gregory G Warr
Pyrrolidinium ionic liquids, especially pyrrolidinium acetate (PyrrAc), have demonstrated outstanding capacity for extracting lignin from biomass, as electrolytes for fuel cells and lithium ion batteries and as solvents for acid-catalysed reactions. In this work we show that the unusual liquid nanostructure of PyrrAc is the key to its versatility as a solvent compared to other ionic liquids. Neutron diffraction with multiple H/D isotopic substitutions reveals that the bulk nanostructure of PyrrAc is a bicontinuous network of interpenetrating polar and apolar domains...
June 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28603966/silver-alginate-hydrogel-micro-and-nano-containers-for-theranostics-synthesis-encapsulation-remote-release-and-detection
#17
Ekaterina Lengert, Mariia Saveleva, Anatolii Abalymov, Vsevolod Atkin, Pieter C Wuytens, Roman Kamyshinsky, Alexander L Vasiliev, Dmitry A Gorin, Gleb B Sukhorukov, Andre G Skirtach, Bogdan Parakhonskiy
We have designed multifunctional silver alginate hydrogel microcontainers referred to as loaded microcapsules with different sizes by assembling them via a template assisted approach using a natural, highly porous calcium carbonate cores. Sodium alginate was immobilized into the pores of calcium carbonate particles of different sizes followed by cross-linking via addition of silver ions, which had a dual purpose: on one hand, the were used as a crosslinking agent, albeit in the monovalent form, while on the other hand they have led to formation of silver nanoparticles...
June 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28599269/inhibition-of-extracellular-matrix-mediated-tgf-%C3%AE-signalling-suppresses-endometrial-cancer-metastasis
#18
Subhransu S Sahoo, Min Yuan Quah, Sarah Nielsen, Joshua Atkins, Gough G Au, Murray J Cairns, Pravin Nahar, Janine M Lombard, Pradeep S Tanwar
Although aggressive invasion and distant metastases are an important cause of morbidity and mortality in patients with endometrial cancer (EC), the requisite events determining this propensity are currently unknown. Using organotypic three-dimensional culture of endometrial cancer cell lines, we demonstrated anti-correlated TGF-β signalling gene expression patterns that arise among extracellular matrix (ECM)-attached cells. TGF-β pathway seemed to be active in EC cells forming non-glandular colonies in 3D-matrix but weaker in glandular colonies...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28595865/profiling-of-translational-and-rotational-head-accelerations-in-youth-bmx-with-and-without-neck-brace
#19
Howard T Hurst, Lee Rylands, Stephen Atkins, Kevin Enright, Simon J Roberts
OBJECTIVES: To investigate the influence of BMX helmets and neck braces on translational and rotational accelerations in youth riders. DESIGN: Mixed model, repeated measure and correlation. METHODS: Twenty three competitive youth BMX riders classified by age group (6-9 years, 10-13 years and 14-18 years) completed 6 laps of an indoor BMX track at race pace, 3 laps without a neck brace (NB) and 3 without brace (WB). A triaxial accelerometer with gyroscope was placed behind the right ear to determine the mean number of accelerations, translational and rotational, of the head between conditions and by age group...
May 25, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28594315/forecasting-financial-resources-for-future-traumatic-spinal-cord-injury-care-using-simulation-modeling
#20
Henry Ahn, Rachel Lewis, Argelio Santos, Christiana L Cheng, Vanessa K Noonan, Marcel F Dvorak, Anoushka Singh, A Gary Linassi, Sean Christie, Michael Goytan, Derek Atkins
Survivors of traumatic spinal cord injury (tSCI) have intense healthcare needs during acute and rehabilitation care and often through rest of life. To prepare for a growing aging population, simulation modeling was used to forecast the change in healthcare financial resources and long-term patient outcomes between 2012 and 2032. The model was developed with data from acute and rehabilitation care facilities across Canada participating in the Access to Care and Timing project. Future population and tSCI incidence for 2012 and 2032 were predicted with data from Statistics Canada and the Canadian Institute for Health Information...
June 8, 2017: Journal of Neurotrauma
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