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https://www.readbyqxmd.com/read/28096419/stromal-cues-regulate-the-pancreatic-cancer-epigenome-and-metabolome
#1
Mara H Sherman, Ruth T Yu, Tiffany W Tseng, Cristovao M Sousa, Sihao Liu, Morgan L Truitt, Nanhai He, Ning Ding, Christopher Liddle, Annette R Atkins, Mathias Leblanc, Eric A Collisson, John M Asara, Alec C Kimmelman, Michael Downes, Ronald M Evans
A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome, yet the mechanistic underpinning of this crosstalk remains poorly understood. Here we show that stromal cues elicit an adaptive response in the cancer cell including the rapid mobilization of a transcriptional network implicated in accelerated growth, along with anabolic changes of an altered metabolome. The close overlap of stroma-induced changes in vitro with those previously shown to be regulated by oncogenic Kras in vivo suggests that oncogenic Kras signaling-a hallmark and key driver of PDAC-is contingent on stromal inputs...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28087549/engaging-stakeholders-and-target-groups-in-prioritising-a-public-health-intervention-the-creating-active-school-environments-case-online-delphi-study
#2
Katie L Morton, Andrew J Atkin, Kirsten Corder, Marc Suhrcke, David Turner, Esther M F van Sluijs
OBJECTIVES: Stakeholder engagement and public involvement are considered as integral to developing effective public health interventions and is encouraged across all phases of the research cycle. However, limited guidelines and appropriate tools exist to facilitate stakeholder engagement-especially during the intervention prioritisation phase. We present the findings of an online 'Delphi' study that engaged stakeholders (including young people) in the process of prioritising secondary school environment-focused interventions that aim to increase physical activity...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28080092/brief-online-interventions-targeting-risk-and-protective-factors-for-increased-and-problematic-alcohol-use-among-american-college-students-studying-abroad
#3
Eric R Pedersen, Clayton Neighbors, David C Atkins, Christine M Lee, Mary E Larimer
Research documents increased and problematic alcohol use during study abroad experiences for college students yet no research documents effective preventive programs with these students. The present randomized controlled trial was designed to prevent increased and problematic alcohol use abroad by correcting misperceptions of peer drinking norms abroad and by promoting positive and healthy adjustment into the host culture (i.e., sojourner adjustment) through brief online personalized feedback interventions...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28079846/patient-confidence-and-quality-of-life-in-idiopathic-pulmonary-fibrosis-and-sarcoidosis
#4
Jalpa Kotecha, Christopher Atkins, Andrew Wilson
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) and sarcoidosis impact significantly on health-related quality of life (HRQOL). There are few studies on the impact of patient confidence on HRQOL in these conditions. OBJECTIVES: 1. To investigate whether patient confidence is associated with HRQOL, anxiety, depression, dyspnoea or fatigue. 2. To assess if patient confidence is associated with inpatient admissions, access to community healthcare and, for IPF patients, mortality and disease severity...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28077220/examining-the-impact-of-suicide-attempt-function-and-perceived-effectiveness-in-predicting-reattempt-for-emergency-medicine-patients
#5
Stephen S O'Connor, Katherine Anne Comtois, David C Atkins, Amanda H Kerbrat
While previous studies have examined motivational aspects of self-directed violence, few studies have included specific motivations in predictive models for future suicide attempts. The current study utilized a sample of 160 individuals treated in an acute emergency setting following a suicide attempt who completed an interview battery that included an assessment of functional aspects of the index suicide attempt. A follow-up interview was conducted at 6 months to ascertain subsequent suicide attempts. The functional domains of suicide attempts were labeled as reduction-of-distress, communication, perceived better alternative to living, and self-loathing...
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28073981/effect-of-resin-ducts-and-sap-content-on-infestation-and-development-of-immature-stages-of-anastrepha-obliqua-and-anastrepha-ludens-diptera-tephritidae-in-four-mango-sapindales-anacardiaceae-cultivars
#6
Larissa Guillén, Ricardo Adaime, Andrea Birke, Olinda Velázquez, Guillermo Angeles, Fernando Ortega, Eliel Ruíz, Martín Aluja
We determined the influence of resin ducts, sap content, and fruit physicochemical features of four mango cultivars (Criollo, Manila, Ataulfo, and Tommy Atkins) on their susceptibility to the attack of the two most pestiferous fruit fly species infesting mangoes in Mexico: Anastrepha ludens (Loew) and Anastrepha obliqua (Macquart). We performed three studies: 1) analysis of resin ducts in mango fruit exocarp to determine the density and area occupied by resin ducts in each mango cultivar, 2) assessment of mango physicochemical features including fruit sap content, and 3) a forced infestation trial under field conditions using enclosed fruit-bearing branches to expose mangoes to gravid A...
January 10, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28073977/the-effects-of-a-modified-hot-water-treatment-on-anastrepha-ludens-diptera-tephritidae-infested-mango
#7
Emilio Hernández, Marysol Aceituno-Medina, Jorge Toledo, Bigail Bravo, José Caro-Corrales, Pablo Montoya, Robert Mangan
The Mexican fruit fly, Anastrepha ludens (Loew), is a quarantine pest in mango (Mangifera indica L.) that can be controlled by using a hot water treatment (HWT). This treatment is normally followed by a 30-min hydrocooling (HYC) process that reduces the negative effects that the treatment has on fruit quality. However, if hot water-treated fruits are immediately immersed in water at 21 °C, the survival rate of third-instar A. ludens may be increased. The current approved treatment protocol states that if HYC is used, then treated fruit should undergo an additional 10-min HWT or on platform for 30 min before HYC...
January 10, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28071774/intermolecular-structure-and-hydrogen-bonding-in-liquid-1-2-propylene-carbonate-and-1-2-glycerol-carbonate-determined-by-neutron-scattering
#8
Yoan M Delavoux, Mark Gilmore, Martin P Atkins, Małgorzata Swadźba-Kwaśny, John D Holbrey
Neutron diffraction with isotopic substitution has been used to investigate the liquid structures of propylene carbonate and glycerol carbonate. C-HO[double bond, length as m-dash]C hydrogen-bonding motifs dominate the local structure of propylene carbonate, giving rise to the formation of head-to-tail correlated chains of molecules. In contrast, glycerol carbonate exhibits a more disordered structure with no overall dominant interactions in which the pendant hydroxyl function disrupts structure-making correlations present in propylene carbonate...
January 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28063216/daily-exposure-to-either-a-high-or-low-energy-dense-snack-food-reduces-its-reinforcing-value-in-adolescents
#9
Jennifer L Temple, Erika Van der Kloet, Amanda M Atkins, Amanda K Crandall, Amanda M Ziegler
OBJECTIVE: To examine the impact of daily exposure to a low-energy-dense (LED) or a high-energy-dense (HED) snack food on its reinforcing value (RRV) in adolescents with healthy weight, overweight, or obesity. METHODS: A parallel-group, randomized trial was used to assess RRV of LED or HED snack food at baseline and again after exposure to that snack food daily for 2 weeks in 77 adolescents, aged 13 to 17 years. Information on eating-related subject characteristics was also collected at baseline...
January 7, 2017: Obesity
https://www.readbyqxmd.com/read/28058955/ecg-of-the-month
#10
James S Mathews, Amanda E Coleman, Clarke E Atkins
No abstract text is available yet for this article.
January 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28057919/isolation-of-cell-type-specific-apoptotic-bodies-by-fluorescence-activated-cell-sorting
#11
Georgia K Atkin-Smith, Stephanie Paone, Damien J Zanker, Mubing Duan, Than K Phan, Weisan Chen, Mark D Hulett, Ivan K H Poon
Apoptotic bodies (ApoBDs) are membrane-bound extracellular vesicles that can mediate intercellular communication in physiological and pathological settings. By combining recently developed analytical strategies with fluorescence-activated cell sorting (FACS), we have developed a method that enables the isolation of ApoBDs from cultured cells to 99% purity. In addition, this approach also enables the identification and isolation of cell type-specific ApoBDs from tissue, bodily fluid and blood-derived samples...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057894/validating-genome-wide-association-candidates-through-quantitative-variation-in-nodulation
#12
Shaun J Curtin, Peter Tiffin, Joseph Guhlin, Diana I Trujillo, Liana T Burghardt, Paul Atkins, Nicholas J Baltes, Roxanne Denny, Daniel F Voytas, Robert M Stupar, Nevin Dale Young
Genome wide association (GWA) studies offer the opportunity to identify genes that contribute to naturally occurring variation in quantitative traits. However, GWA relies exclusively on statistical association, so functional validation is necessary to make strong claims about gene function. We used a combination of gene-disruption platforms (Tnt1 retro-transposons, hairpin RNA-interference constructs, and CRISPR/Cas9 nucleases) together with randomized, well-replicated experiments to evaluate the function of genes that an earlier GWAS in Medicago truncatula had identified as candidates contributing to variation in the symbiosis between legumes and rhizobia...
January 5, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28056910/collaboration-between-employers-and-occupational-health-service-providers-a-systematic-review-of-key-characteristics
#13
Jaana I Halonen, Salla Atkins, Hanna Hakulinen, Sanna Pesonen, Jukka Uitti
BACKGROUND: Employees are major contributors to economic development, and occupational health services (OHS) can have an important role in supporting their health. Key to this is collaboration between employers and OHS. We reviewed the evidence regarding the characteristics of good collaboration between employers and OHS providers that is essential to construct more effective collaboration and services. METHODS: A systematic review of the factors of good collaboration between employers and OHS providers was conducted...
January 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28056628/optimizing-clinical-decision-making-in-acute-traumatic-spinal-cord-injury
#14
Michael Fehlings, Vanessa Noonan, Derek Atkins, Anthony Scott Burns, Christiana L Cheng, Anoushka Singh, Marcel F Dvorak
Please note that as this is the introductory article, there is no abstract for this article.
January 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28053859/is-there-a-role-for-diet-monotherapy-in-adult-epilepsy
#15
Mackenzie C Cervenka, Bobbie J Henry-Barron, Eric H Kossoff
Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28040759/novel-application-of-a-percutaneous-left-ventricular-assist-device-as-a-bridge-to-transplant-in-a-paediatric-patient-with-severe-heart-failure-due-to-viral-myocarditis
#16
Paul Perry, Elizabeth David, Broadus Atkins, Gary Raff
A 13-year obese female with suspected viral myocarditis presented with acute decompensated heart failure. Due to her body habitus, she was a poor candidate for immediate heart transplantation. A peripherally inserted left ventricular assist device (LVAD) was implanted via the right axillary artery. Following device insertion the patient experienced rapid improvement in symptoms. The LVAD provided effective left ventricular unloading for 50 days, promoting myocardial recovery and maintaining excellent patient performance status...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28040610/the-impact-of-metastasis-on-the-mineral-phase-of-vertebral-bone-tissue
#17
Mikhail Burke, Ayelet Atkins, Alex Kiss, Margarete Akens, Albert Yee, Cari Whyne
The negative impact of metastases on the mechanical performance of vertebral bone is often attributed to reduced bone density and/or compromised architecture. However limited characterization has been done on the impact of metastasis on the mineralization of bone tissue and resulting changes in material behaviour. This study aimed to evaluate the impact of metastasis on micro and nano scale characteristics of the mineral phase of bone, specifically mineral crystal growth, homogeneity of mineralization and changes in intrinsic material properties...
December 23, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28031424/the-dart-study-results-from-the-dose-escalation-and-expansion-cohorts-evaluating-the-combination-of-dalantercept-plus-axitinib-in-advanced-renal-cell-carcinoma
#18
Martin H Voss, Rupal S Bhatt, Elizabeth R Plimack, Brian I Rini, Robert S Alter, J Thaddeus Beck, Dawn Wilson, Xiaosha Zhang, Musa Mutyaba, Chad Glasser, Kenneth M Attie, Matthew L Sherman, Shuchi S Pandya, Michael Atkins
PURPOSE: Activin receptor-like kinase 1 (ALK1) is a novel target in angiogenesis. Concurrent targeting of ALK1 and vascular endothelial growth factor (VEGF) signaling results in augmented inhibition of tumor growth in renal cell carcinoma (RCC) xenograft models. Dalantercept is an ALK1 receptor-fusion protein that acts as a ligand trap for bone morphogenetic proteins (BMP) 9 and 10. The DART Study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept plus axitinib in patients with advanced RCC and determined the optimal dose for further testing...
December 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28009655/amiodarone-versus-lidocaine-for-pediatric-cardiac-arrest-due-to-ventricular-arrhythmias-a-systematic-review
#19
Mary E McBride, Bradley S Marino, Gregory Webster, Jesús Lopez-Herce, Carolyn P Ziegler, Allan R De Caen, Dianne L Atkins
OBJECTIVE: We performed a systematic review as part of the International Liaison Committee on Resuscitation process to create a consensus on science statement regarding amiodarone or lidocaine during pediatric cardiac arrest for the 2015 International Liaison Committee on Resuscitation's Consensus on Science and Treatment Recommendations. DATA SOURCES: Studies were identified from comprehensive searches in PubMed, Embase, and the Cochrane Library. STUDY SELECTION: Studies eligible for inclusion were randomized controlled and observational studies on the relative clinical effect of amiodarone or lidocaine in cardiac arrest...
December 23, 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28008324/vitamin-d3-for-the-treatment-of-epilepsy-basic-mechanisms-animal-models-and-clinical-trials
#20
REVIEW
Kevin Pendo, Christopher M DeGiorgio
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D3 is actively under investigation as a potential intervention for epilepsy. Vitamin D3 is fat-soluble steroid, which shows promise in animal models of epilepsy. Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy...
2016: Frontiers in Neurology
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