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https://www.readbyqxmd.com/read/28822119/five-questions-answered-a-review-of-autologous-hematopoietic-stem-cell-transplantation-for-the-treatment-of-multiple-sclerosis
#1
REVIEW
Harold L Atkins, Mark S Freedman
Multiple sclerosis (MS) is thought to be an autoimmune disease targeting the central nervous system leading to demyelination, and axonal and neuronal damage, resulting in progressive disability. More intensive therapies such as immunodepletion with hematopoietic stem-cell rescue are being used at a time prior to patients becoming irreversibly disabled. Over the last 15 years, there has been a shift away from using autologous hematopoietic stem-cell transplants (aHSCT) to treat patients with progressive MS, towards treating those with active inflammation and relapses...
August 18, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28821454/low-dose-anti-thymocyte-globulin-for-graft-versus-host-disease-prophylaxis-in-matched-unrelated-allogeneic-hematopoietic-stem-cell-transplant
#2
A Bryant, R Mallick, L Huebsch, D Allan, H Atkins, G Anstee, M Sabloff, N Scrivens, D Maze, C Bredeson, N Kekre
Graft-versus-host disease (GVHD) is a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloHCT). Prophylactic in-vivo T-Cell depletion with antithymocyte globulin (ATG) has been associated with decreased GVHD rates many alloHCT settings. Despite decades of clinical study, optimal ATG dosing has not been established. Understanding that higher rates of GVHD are observed with matched unrelated (MUD) versus matched related donor (MRD) alloHCT, at our institution MUD alloHSCT recipients have historically had low dose thymoglobulin (total dose 2...
August 15, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28820513/predictors-of-unplanned-hospitalizations-in-patients-with-nonmetastatic-lung-cancer-during-chemotherapy
#3
Kristen L Fessele, Matthew J Hayat, Robert L Atkins
PURPOSE/OBJECTIVES: To determine predictors of unplanned hospitalizations in patients with lung cancer to receive chemotherapy in the outpatient setting and examine the potential financial burden of these events.
. DESIGN: Retrospective, longitudinal cohort study.
. SETTING: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database.
. SAMPLE: Of 104,388 incident cases of lung cancer diagnosed from 2005-2009, 2,457 cases of patients with lung cancer who received outpatient chemotherapy were identified...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28815387/image-guided-surgical-robotic-system-for-percutaneous-reduction-of-joint-fractures
#4
Giulio Dagnino, Ioannis Georgilas, Samir Morad, Peter Gibbons, Payam Tarassoli, Roger Atkins, Sanja Dogramadzi
Complex joint fractures often require an open surgical procedure, which is associated with extensive soft tissue damages and longer hospitalization and rehabilitation time. Percutaneous techniques can potentially mitigate these risks but their application to joint fractures is limited by the current sub-optimal 2D intra-operative imaging (fluoroscopy) and by the high forces involved in the fragment manipulation (due to the presence of soft tissue, e.g., muscles) which might result in fracture malreduction. Integration of robotic assistance and 3D image guidance can potentially overcome these issues...
August 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28808808/ketogenic-diet-versus-gluten-free-casein-free-diet-in-autistic-children-a-case-control-study
#5
Omnia El-Rashidy, Farida El-Baz, Yasmin El-Gendy, Randa Khalaf, Dina Reda, Khaled Saad
Many diet regimens were studied for patients with autism spectrum disorder (ASD) over the past few years. Ketogenic diet is gaining attention due to its proven effect on neurological conditions like epilepsy in children. Forty-five children aged 3-8 years diagnosed with ASD based on DSM-5 criteria were enrolled in this study. Patients were equally divided into 3 groups, first group received ketogenic diet as modified Atkins diet (MAD), second group received gluten free casein free (GFCF) diet and the third group received balanced nutrition and served as a control group...
August 14, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28806955/reducing-the-socioeconomic-gradient-in-uptake-of-the-nhs-bowel-cancer-screening-programme-using-a-simplified-supplementary-information-leaflet-a-cluster-randomised-trial
#6
Samuel G Smith, Jane Wardle, Wendy Atkin, Rosalind Raine, Lesley M McGregor, Gemma Vart, Steve Morris, Stephen W Duffy, Susan Moss, Allan Hackshaw, Stephen Halloran, Ines Kralj-Hans, Rosemary Howe, Julia Snowball, Graham Handley, Richard F Logan, Sandra Rainbow, Steve Smith, Mary Thomas, Nicholas Counsell, Christian von Wagner
BACKGROUND: Uptake of colorectal cancer screening is low in the English NHS Bowel Cancer Screening Programme (BCSP). Participation in screening is strongly associated with socioeconomic status. The aim of this study was to determine whether a supplementary leaflet providing the 'gist' of guaiac-based Faecal Occult Blood test (gFOBt) screening for colorectal cancer could reduce the socioeconomic status (SES) gradient in uptake in the English NHS BCSP. METHODS: The trial was integrated within routine BCSP operations in November 2012...
August 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28806360/achieving-health-equity-federal-perspectives-for-21st-century-health-system-research-priorities
#7
David Atkins, Eliseo J Pérez-Stable, Amy M Kilbourne
No abstract text is available yet for this article.
September 2017: Medical Care
https://www.readbyqxmd.com/read/28803887/a-miniaturized-peptidyl-prolyl-isomerase-enzyme-assay
#8
Mirella Vivoli, Julien Renou, Arnaud Chevalier, Isobel H Norville, Suraya Diaz, Christina Juli, Helen Atkins, Ulrike Holzgrabe, Pierre-Yves Renard, Mitali Sarkar-Tyson, Nicholas J Harmer
Prolyl-peptidyl isomerases (PPIases) are enzymes that are found in all living organisms. They form an essential part of the cellular protein folding homeostasis machinery. PPIases are associated with many important human diseases, e.g. cardiovascular disease, cancer and Alzheimer's. The development of novel PPIase inhibitors has been limited by the lack of a rapid, laboratory-based assay for these enzymes, as their substrates and products are challenging to distinguish. A well described continuous assay, coupled with the hydrolysis of a peptide by chymotrypsin is highly effective, but comparatively slow...
August 10, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28802317/aoac-smpr-%C3%A2-2017-002
#9
Susan Audino, Mark Angerhofer, Patricia Atkins, Roger M Brauninger, Paula N Brown, Carolyn Quarles Burdette, Robert Clifford, Jo Marie Cook, Jennifer Donelson, Kevin George, Peter Gibson, Heather L Harris, Thomas Hartlein, George Hodgin, Dorota Inerowicz, Holly E Johnson, George Joseph, Erik J M Konings, Julie A Kowalski, Mary Kay Krogull, Scott Kuzdzal, Robert Lockerman, Cynthia Ludwig, Christina Marrongelli, Katerina Mastovska, Elizabeth Mudge, Gary D Niehaus, Masayuki Nishimura, Melissa Meaney Phillips, Curtis S Phinney, Klaus Reif, Amanda Rigdon, Catherine A Rimmer, Travis Ruthenburg, Aniko M Solyom, Katherine Stenerson, Sidney Sudberg, Alan Sutton, John Szpylka, Jane Weitzel, Paul Winkler, Seth Wong, Joshua Wurzer, Hong You, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802316/aoac-smpr-%C3%A2-2017-001
#10
Susan Audino, Mark Angerhofer, Patricia Atkins, Roger M Brauninger, Paula N Brown, Carolyn Quarles Burdette, Robert Clifford, Jo Marie Cook, Jennifer Donelson, Kevin George, Peter Gibson, Heather L Harris, Thomas Hartlein, George Hodgin, Dorota Inerowicz, Holly E Johnson, George Joseph, Erik J M Konings, Julie A Kowalski, Mary Kay Krogull, Scott Kuzdzal, Robert Lockerman, Cynthia Ludwig, Christina Marrongelli, Katerina Mastovska, Elizabeth Mudge, Gary D Niehaus, Masayuki Nishimura, Melissa Meaney Phillips, Curtis S Phinney, Klaus Reif, Amanda Rigdon, Catherine A Rimmer, Travis Ruthenburg, Aniko M Solyom, Katherine Stenerson, Sidney Sudberg, Alan Sutton, John Szpylka, Jane Weitzel, Paul Winkler, Seth Wong, Joshua Wurzer, Hong You, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28799727/cryosurgical-posterior-nasal-tissue-ablation-for-the-treatment-of-rhinitis
#11
Peter H Hwang, Bryant Lin, Raymond Weiss, James Atkins, Jacob Johnson
BACKGROUND: Endoscopic posterior nasal nerve (PNN) resection has been described as an efficacious surgical treatment of allergic and nonallergic rhinitis, but the requirement for surgery under general anesthesia has limited its acceptance. We report the first series of patients treated for chronic rhinitis using a novel device designed for office-based cryosurgical ablation of the PNN. METHODS: Twenty-seven patients with chronic rhinorrhea and/or nasal congestion for >3 months were recruited (allergic or nonallergic rhinitis), with minimum rhinorrhea and/or congestion subscores of 2 as part of the Total Nasal Symptom Score [TNSS])...
August 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28799513/ketogenic-diets-in-the-treatment-of-epilepsy
#12
Maurizio Elia, Joerg Klepper, Baerbel Leiendecker, Hans Hartmann
BACKGROUND: Although a larger number of antiepileptic drugs became available in the last decades, epilepsy remains drug-resistant in approximately a third of patients. Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not completely understood. Over the last decades, different types of ketogenic diets (KDs) have been developed, namely classical KD and modified Atkins diet (MAD). They offer an effective alternative for children and adults with drug-resistant epilepsies...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28799237/anticancer-efficacy-of-the-hypoxia-activated-prodrug-evofosfamide-is-enhanced-in-combination-with-proapoptotic-receptor-agonists-against-osteosarcoma
#13
Vasilios Liapis, Aneta Zysk, Mark DeNichilo, Irene Zinonos, Shelley Hay, Vasilios Panagopoulos, Alexandra Shoubridge, Christopher Difelice, Vladimir Ponomarev, Wendy Ingman, Gerald J Atkins, David M Findlay, Andrew C W Zannettino, Andreas Evdokiou
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors. Evofosfamide is a hypoxia-activated prodrug that is created by linking the hypoxia-seeking 2-nitroimidazole moiety to the cytotoxic bromo-isophosphoramide mustard (Br-IPM). When evofosfamide is delivered to hypoxic regions of tumors, the DNA cross-linking toxin, Br-IPM, is released leading to cell death...
August 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28798433/a-guide-to-building-mi-oral-healthcare-practice
#14
B Dawett, B Atkins, A Banerjee
Minimum intervention dentistry (MID) is the evidence-based delivery of oral healthcare which aims to maximise preservation of tooth structure and longevity of tooth life, improving long-term oral health and wellbeing. In general dental practice implementing such an ethos and approach can require change in the practice structure and processes. Such change in processes requires careful management and planning. Planning should include financial as well as business planning. A detailed understanding of the planning that may be required is described here as a guide to help oral healthcare practice staff and other stakeholders to facilitate the delivery of MID...
August 11, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28780551/the-indigenous-counselling-and-nicotine-ican-quit-in-pregnancy-pilot-study-protocol-a-feasibility-step-wedge-cluster-randomised-trial-to-improve-health-providers-management-of-smoking-during-pregnancy
#15
Yael Bar-Zeev, Billie Bonevski, Michelle Bovill, Maree Gruppetta, Chris Oldmeadow, Kerrin Palazzi, Lou Atkins, Jennifer Reath, Gillian S Gould
INTRODUCTION: Indigenous women have the highest smoking prevalence during pregnancy (47%) in Australia. Health professionals report lack of knowledge, skills and confidence to effectively manage smoking among pregnant women in general. We developed a behaviour change intervention aimed to improve health professionals' management of smoking in Indigenous pregnant women-the Indigenous Counselling And Nicotine (ICAN) QUIT in Pregnancy. This intervention includes webinar training for health professionals, an educational resources package for health professionals and pregnant women, free oral nicotine replacement therapy (NRT) for pregnant women, and audit and feedback on health professionals' performance...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28766339/trajectory-surface-hopping-dynamics-including-intersystem-crossing-in-ru-bpy-3-2
#16
Andrew J Atkins, Leticia González
Surface-hopping dynamics coupled to linear response TDDFT and explicit nonadiabatic and spin-orbit couplings have been used to model the ultrafast intersystem crossing (ISC) dynamics in [Ru(bpy)3](2+). Simulations using an ensemble of trajectories starting from the singlet metal-to-ligand charge transfer ((1)MLCT) band show that the manifold of (3)MLCT triplet states is first populated from high-lying singlet states within 26 ± 3 fs. ISC competes with an intricate internal conversion relaxation process within the singlet manifold to the lowest singlet state...
August 4, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28765041/evidence-for-altered-osteoclastogenesis-in-splenocyte-cultures-from-vdr-knockout-mice
#17
Daniel C Reinke, Yolandi Starczak, Masakazu Kogawa, Kate R Barratt, Howard A Morris, Paul H Anderson, Gerald J Atkins
The indirect action of 1α,25(OH)2-vitamin-D3 (1,25D) on the osteoclast through stromal signalling is well established. The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known. We showed previously that local 1,25D synthesis in osteoclasts modified osteoclastogenesis and osteoclastic resorptive activity. In this study, we hypothesised that osteoclasts lacking VDR expression would display an enhanced resorptive capacity due to the loss of 1,25D signalling. Splenocytes were cultured under osteoclast-differentiating conditions from mice with global deletion of the Vdr gene (VDRKO) and this was compared with age-matched wild-type littermate controls (WT)...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28761656/androstenedione-and-testosterone-levels-correlate-with-in-vitro-fertilization-rates-in-insulin-resistant-women
#18
Thozhukat Sathyapalan, Emily H Dickerson, Stephen M Maguiness, John Robinson, Youssra H Z Dakroury, Stephen L Atkin
BACKGROUND: The free androgen index (FAI) calculated using total testosterone measured by immunoassay does not correlate with oocyte fertilization rates; however, there is considerable cross-reactivity for testosterone with other androgens by immunoassay that is not found using isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS). AIMS: This study was done to determine relationship between total testosterone and androstenedione measured by LC/MS/MS and fertilization rates...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761628/modified-atkins-diet-in-adult-with-refractory-epilepsy-a-controlled-randomized-clinical-trial
#19
Mohammad Zare, Ali Asghar Okhovat, Ahmad Esmaillzadeh, Jafar Mehvari, Mohammad Reza Najafi, Mohammad Saadatnia
Background: The usefulness of the modified Atkins diet (mAD) in refractory epilepsy in adults has been rarely investigated. We aimed to evaluate the efficacy of mAD in adult with refractory epilepsy. Methods: In a controlled randomized clinical trial, we enrolled 66 refractory adult epileptic cases from February 2010 to December 2012. The patients were randomly divided into two groups, case groups (22 patients) used antiepileptic drugs and mAD and control group (32 patients) only use antiepileptic drugs. The primary outcome was at least 50% decrement in seizure frequency after 2 months of therapy...
April 4, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28758964/effects-of-popular-diets-without-specific-calorie-targets-on-weight-loss-outcomes-systematic-review-of-findings-from-clinical-trials
#20
Stephen D Anton, Azumi Hida, Kacey Heekin, Kristen Sowalsky, Christy Karabetian, Heather Mutchie, Christiaan Leeuwenburgh, Todd M Manini, Tracey E Barnett
The present review examined the evidence base for current popular diets, as listed in the 2016 U.S. News & World Report, on short-term (≤six months) and long-term (≥one year) weight loss outcomes in overweight and obese adults. For the present review, all diets in the 2016 U.S. News & World Report Rankings for "Best Weight-Loss Diets", which did not involve specific calorie targets, meal replacements, supplementation with commercial products, and/or were not categorized as "low-calorie" diets were examined...
July 31, 2017: Nutrients
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