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https://www.readbyqxmd.com/read/28729151/standard-dose-pembrolizumab-in-combination-with-reduced-dose-ipilimumab-for-patients-with-advanced-melanoma-keynote-029-an-open-label-phase-1b-trial
#1
Georgina V Long, Victoria Atkinson, Jonathan S Cebon, Michael B Jameson, Bernie M Fitzharris, Catriona M McNeil, Andrew G Hill, Antoni Ribas, Michael B Atkins, John A Thompson, Wen-Jen Hwu, F Stephen Hodi, Alexander M Menzies, Alexander D Guminski, Richard Kefford, Benjamin Y Kong, Babak Tamjid, Archana Srivastava, Anna J Lomax, Mohammed Islam, Xinxin Shu, Scot Ebbinghaus, Nageatte Ibrahim, Matteo S Carlino
BACKGROUND: Reduced-dose nivolumab in combination with standard-dose ipilimumab improves objective response and progression-free survival compared with standard-dose ipilimumab alone, but increases toxicity. We assessed the safety and anti-tumour activity of standard-dose pembrolizumab in combination with reduced-dose ipilimumab. METHODS: In this open-label, phase 1b trial, we recruited patients from 12 medical centres in Australia, New Zealand, and the USA. Eligible patients were aged at least 18 years, had advanced melanoma, had an Eastern Coooperative Oncology Group performance status of 0 or 1, had measurable disease according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1...
July 17, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28723965/the-prevalence-and-metabolic-characteristics-of-polycystic-ovary-syndrome-in-the-qatari-population
#2
Soha R Dargham, Lina Ahmed, Eric S Kilpatrick, Stephen L Atkin
OBJECTIVE: The prevalence of polycystic ovary syndrome (PCOS) in the Qatari population is unknown and hence the estimated impact on the local population cannot be determined. The purpose of this study was to estimate the prevalence and metabolic features of PCOS among Qatari women. DESIGN: Cross sectional analysis. PATIENTS: 3,017 Qatari subjects volunteered to be phenotyped and genotyped for the Qatar Biobank from which all women between the ages of 18-40 years were identified (750)...
2017: PloS One
https://www.readbyqxmd.com/read/28719253/cost-effectiveness-evaluation-of-a-novel-integrated-bite-case-management-program-for-the-control-of-human-rabies-haiti-2014-2015
#3
Eduardo A Undurraga, Martin I Meltzer, Cuc H Tran, Charisma Y Atkins, Melissa D Etheart, Max F Millien, Paul Adrien, Ryan M Wallace
AbstractHaiti has the highest burden of rabies in the Western hemisphere, with 130 estimated annual deaths. We present the cost-effectiveness evaluation of an integrated bite case management program combining community bite investigations and passive animal rabies surveillance, using a governmental perspective. The Haiti Animal Rabies Surveillance Program (HARSP) was first implemented in three communes of the West Department, Haiti. Our evaluation encompassed all individuals exposed to rabies in the study area (N = 2,289) in 2014-2015...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719152/a-first-in-human-phase-i-multicenter-open-label-dose-escalation-study-of-the-oral-raf-vegfr-2-inhibitor-raf265-in-locally-advanced-or-metastatic-melanoma-independent-from-braf-mutation-status
#4
Benjamin Izar, William Sharfman, F Stephen Hodi, Donald Lawrence, Keith T Flaherty, Ravi Amaravadi, Kevin B Kim, Igor Puzanov, Jeffrey Sosman, Reinhard Dummer, Simone M Goldinger, Lyhping Lam, Shefali Kakar, Zhongwen Tang, Oliver Krieter, David F McDermott, Michael B Atkins
To establish the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety profile, and anti-tumor efficacy of RAF265. We conducted a multicenter, open-label, phase-I, dose-escalation trial of RAF265, an orally available RAF kinase/VEGFR-2 inhibitor, in patients with advanced or metastatic melanoma. Pharmacokinetic (PK) analysis, pharmacodynamics (PD) and tumor response assessment were conducted. We evaluated metabolic tumor response by 18[F]-fluorodeoxyglucose-positron-emission tomography (FDG-PET), tissue biomarkers using immunohistochemistry (IHC), and modulators of angiogenesis...
July 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28717871/sleeve-gastrectomy-telementoring-a-sages-multi-institutional-quality-improvement-initiative
#5
Ninh T Nguyen, Allan Okrainec, Mehran Anvari, Brian Smith, Oz Meireles, Denise Gee, Erin Moran-Atkin, Evelyn Baram-Clothier, Diego R Camacho
BACKGROUND: Sleeve gastrectomy is a relatively new procedure that developed as a result of rapid innovation in the field of bariatric surgery. As with any newly developed operation, there is a learning curve that potentially can be associated with higher morbidity. Real-time surgical mentoring reduces the learning curve effect but can be time intensive for the mentor. The aim of this initiative was to evaluate the feasibility, effectiveness, and satisfaction of surgical telementoring for laparoscopic sleeve gastrectomy...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28713465/a-comparison-of-gps-workload-demands-in-match-play-and-small-sided-games-by-the-positional-role-in-youth-soccer
#6
Mathew Beenham, David J Barron, John Fry, Howard H Hurst, Antonio Figueirdo, Steve Atkins
The external demands of small-sided games (SSGs) according to the positional role are currently unknown. Using a Catapult Minimax X3 5 Hz GPS, with a 100 Hz tri-axial accelerometer, we compared the accumulated tri-axial player workload per min (PLacc·min(-1)) during friendly youth match play (MP) (11 vs. 11) and SSGs (2 vs. 2, 3 vs. 3, and 4 vs. 4). Significant differences existed between all SSGs and MP for PLacc·min(-1) (F = 21.91, p < 0.001, η2 = 0.38), and individual X (F = 27.40, p < 0.001, η2 = 0...
June 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28710340/induction-of-the-unfolded-protein-response-in-familial-amyotrophic-lateral-sclerosis-and-association-of-protein-disulfide-isomerase-with-superoxide-dismutase-1
#7
Julie D Atkin, Manal A Farg, Bradley J Turner, Doris Tomas, Judith A Lysaght, Janelle Nunan, Alan Rembach, Phillip Nagley, Philip M Beart, Surindar S Cheema, Malcolm K Horne
No abstract text is available yet for this article.
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28705172/endocannabinoid-receptor-blockade-reduces-alanine-aminotransferase-in-polycystic-ovary-syndrome-independent-of-weight-loss
#8
Alison J Dawson, Eric S Kilpatrick, Anne-Marie Coady, Abeer M M Elshewehy, Youssra Dakroury, Lina Ahmed, Stephen L Atkin, Thozhukat Sathyapalan
BACKGROUND: Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial. The aim of this study was to determine the impact of rimonabant (CB1 antagonist) on alanine aminotransferase (ALT), a hepatocellular injury marker, and a hepatic inflammatory cytokine profile. METHODS: Post hoc review of 2 studies involving 50 obese women with PCOS and well matched for weight, randomised to weight reducing therapy; rimonabant (20 mg od) or orlistat (120 mg tds), or to insulin sensitising therapy metformin, (500 mg tds), or pioglitazone (45 mg od)...
July 14, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28698184/the-association-of-mammographic-density-and-molecular-breast-cancer-subtype
#9
Brandy L Edwards, Kristen A Atkins, George J Stukenborg, Wendy M Novicoff, Krista N Larson, Wendy F Cohn, Jennifer A Harvey, Anneke T Schroen
BACKGROUND: Mammographic density (MD) is associated with increased breast cancer (BC) risk, yet limited data exists on an association between MD and BC molecular subtypes. METHODS: Women 18 years and older with BC and available mammograms between 2003-2012 were enrolled in a larger study on MD. MD was classified by Breast Imaging Reporting and Data System (BI-RADS) classification and by volumetric breast percent density (Volpara SolutionsTM). Subtype was assigned by hormone receptor-status, tumor grade and mitotic score (MS)...
July 11, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28687854/neuroprotective-effects-of-vitamin-d-alone-or-in-combination-with-lamotrigine-against-lithium-pilocarpine-model-of-status-epilepticus-in-rats
#10
Amal M Mahfoz, Ali F Abdel-Wahab, Mohamed A Afify, Naiyer Shahzad, Ibrahim A A Ibrahim, Naser A ElSawy, Ghazi A Bamagous, Saeed S Al Ghamdi
Status epilepticus (SE) is considered one of the major serious forms of epilepsy with high mortality rate. Since the currently available antiepileptic drugs have low efficacy and high adverse effects, new more efficient and safe therapies are critically needed. There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Recent studies have shown significant prophylactic and therapeutic potential of vitamin D (vit-D) use in many neurological disorders...
July 7, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28684826/aggressive-denosumab-related-jaw-necrosis-a-case-series
#11
M Badr, E Kyriakidou, A Atkins, S Harrison
Medication related osteonecrosis of the jaw is becoming a repeatedly seen complication in cancer patients. Stage 0 of the disease is more likely to be seen by the patients' general dental practitioners. We are presenting four cases of MRONJ related to denosumab treatment showing increasingly aggressive pictures of the disease. Nevertheless, we also present a good response to a drug holiday arranged by the patients' treating oncologists.
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28682639/in-vivo-measurements-of-the-ischiofemoral-space-in-recreationally-active-participants-during-dynamic-activities-a-high-speed-dual-fluoroscopy-study
#12
Penny R Atkins, Niccolo M Fiorentino, Stephen K Aoki, Christopher L Peters, Travis G Maak, Andrew E Anderson
BACKGROUND: Ischiofemoral impingement (IFI) is a dynamic process, but its diagnosis is often based on static, supine images. PURPOSE: To couple 3-dimensional (3D) computed tomography (CT) models with dual fluoroscopy (DF) images to quantify in vivo hip motion and the ischiofemoral space (IFS) in asymptomatic participants during weightbearing activities and evaluate the relationship of dynamic measurements with sex, hip kinematics, and the IFS measured from axial magnetic resonance imaging (MRI)...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28679761/the-host-e3-ubiquitin-ligase-trim6-ubiquitinates-the-ebola-virus-vp35-protein-and-promotes-virus-replication
#13
Preeti Bharaj, Colm Atkins, Priya Luthra, Maria Isabel Giraldo, Brian E Dawes, Lisa Miorin, Jeffrey R Johnson, Nevan J Krogan, Christopher F Basler, Alexander N Freiberg, Ricardo Rajsbaum
Ebola virus (EBOV), a member of the Filoviridae family, is a highly pathogenic virus that causes severe hemorrhagic fever in humans and is responsible for epidemics throughout sub-Saharan, central and West Africa. The EBOV genome encodes for VP35, an important viral protein involved in virus replication by acting as an essential cofactor of the viral polymerase as well as a potent antagonist of the host antiviral type-I interferon (IFN-I) system. By using mass spectrometry analysis and co-immunoprecipitation assays, we show here that VP35 is ubiquitinated on lysine 309 (K309), a residue located on its IFN antagonist domain...
July 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28671671/wnt-%C3%AE-catenin-activation-and-macrophage-induction-during-liver-cancer-development-following-steatosis
#14
A Debebe, V Medina, C-Y Chen, I M Mahajan, C Jia, D Fu, L He, N Zeng, B W Stiles, C-L Chen, M Wang, K-R Aggarwal, Z Peng, J Huang, J Chen, M Li, T Dong, S Atkins, Z Borok, W Yuan, K Machida, C Ju, M Kahn, D Johnson, B L Stiles
Obesity confers an independent risk for carcinogenesis. In the liver, steatosis often proceeds cancer formation; however, the mechanisms by which steatosis promotes carcinogenesis is unknown. We hypothesize that steatosis alters the microenvironment to promote proliferation of tumor initiating cells (TICs) and carcinogenesis. We used several liver cancer models to address the mechanisms underlying the role of obesity in cancer and verified these findings in patient populations. Using bioinformatics analysis and verified by biochemical assays, we identified that hepatosteatosis resulting from either Pten deletion or transgenic expression of HCV core/NS5A proteins, promotes the activation of Wnt/β-catenin...
July 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28667155/branch-president-gives-evidence-at-scottish-parliament
#15
(no author information available yet)
As the Scottish Government moves forward with its recently announced package of measures on animal health and welfare, Hayley Atkin, BVA Policy Officer, describes a busy month for the President of BVA Scottish Branch representing members in the Scottish Parliament.
July 1, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28662757/abdominal-wall-endometriosis-in-a-rhesus-macaque-macaca-mulatta
#16
Hannah M Atkins, David L Caudell, A Robert Hutchison, Andre C LeGrande, Nancy D Kock
Endometriosis is the presence of endometrium outside of the uterus. Although endometriosis occurs in both pelvic and extrapelvic locations, extrapelvic locations are less common. The development of abdominal wall or incisional endometriosis in women is associated with gynecologic surgeries and is often misdiagnosed. Because they naturally develop endometriosis similar to women, Old World NHP, including rhesus macaques, provide excellent opportunities for studying endometriosis. Here, we describe a case of abdominal wall endometriosis in a rhesus macaque that had undergone cesarean section...
June 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28655822/translation-initiation-from-conserved-non-aug-codons-provides-additional-layers-of-regulation-and-coding-capacity
#17
Ivaylo P Ivanov, Jiajie Wei, Stephen Z Caster, Kristina M Smith, Audrey M Michel, Ying Zhang, Andrew E Firth, Michael Freitag, Jay C Dunlap, Deborah Bell-Pedersen, John F Atkins, Matthew S Sachs
Neurospora crassa cpc-1 and Saccharomyces cerevisiae GCN4 are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation. The cpc-1 mRNA contains two upstream open reading frames (uORFs) in its >700-nucleotide (nt) 5' leader, and its expression is controlled at the level of translation in response to amino acid starvation. We used N. crassa cell extracts and obtained data indicating that cpc-1 uORF1 and uORF2 are functionally analogous to GCN4 uORF1 and uORF4, respectively, in controlling translation...
June 27, 2017: MBio
https://www.readbyqxmd.com/read/28655593/collagen-fibril-organization-within-rat-vertebral-bone-modified-with-metastatic-involvement
#18
Mikhail Burke, Ahmad Golaraei, Ayelet Atkins, Margarete Akens, Virginijus Barzda, Cari Whyne
Metastatic involvement diminishes the mechanical integrity of vertebral bone, however its specific impact on the structural characteristics of a primary constituent of bone tissue, the collagen-I fibril matrix, has not been adequately characterized. Female athymic rats were inoculated with HeLa or Ace-1 cancer cells lines producing osteolytic or mixed (osteolytic & osteoblastic) metastases respectively. A maximum of 21days was allowed between inoculation and rat sacrifice for vertebrae extraction. Linear polarization-in, polarization-out (PIPO) second harmonic generation (SHG) and transmission electron microscopy (TEM) imaging was utilized to assess the impact of metastatic involvement on collagen fibril organization...
June 24, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28651775/temporary-removal-departing-from-the-essential-features-of-a-high-quality-systematic-review-of-psychotherapy-a-response-to-%C3%A3-st-2014-and-recommendations-for-improvement
#19
Paul W B Atkins, Joseph Ciarrochi, Brandon A Gaudiano, Jonathan B Bricker, James Donald, Graciela Rovner, Matthew Smout, Fredrik Livheim, Tobias Lundgren, Steven C Hayes
Please note that this is not a retraction, but a temporary take down. It will be published once Dr Ost's response has been received (it is expected sometime in approximately the next couple of months).The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
May 29, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28647512/effect-of-dipeptidyl-peptidase-4-inhibitors-on-circulating-tumor-necrosis-factor-%C3%AE-concentrations-a-systematic-review-and-meta-analysis-of-controlled-trials
#20
REVIEW
Stephen L Atkin, Niki Katsiki, Maciej Banach, Dimitri P Mikhailidis, Matteo Pirro, Amirhossein Sahebkar
OBJECTIVE: Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes mellitus. There are also reports of an effect of these drugs in reducing inflammation through inhibition of tumor necrosis factor-α (TNF-α) that is an important mediator for several inflammatory processes. The present systematic review and meta-analysis were performed to evaluate the effect of DPP-4 inhibitors on circulating TNF-α levels in T2DM patients. METHODS: A systematic review and a meta-analysis were undertaken on all controlled trials of DPP-4 inhibitors that included measurement of TNF-α...
June 3, 2017: Journal of Diabetes and its Complications
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