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https://www.readbyqxmd.com/read/29455407/a-single-center-experience-examining-the-length-of-stay-and-safety-of-early-discharge-after-laparoscopic-roux-en-y-gastric-bypass-surgery
#1
Melanie H Howell, Aaron Praiss, Dina Podolsky, Natan Zundel, Erin Moran-Atkin, Jenny J Choi, Diego R Camacho
PURPOSE: This study's objective was to describe our experience and evaluate the safety of early discharge (ED) following laparoscopic Roux-en-Y gastric bypass (LRYGB) in a specific patient population. MATERIALS AND METHODS: Patients undergoing LRYGB at Montefiore Medical Center were retrospectively reviewed. Patients readmitted in the first 30 days following surgery were compared to those patients who were not readmitted. Data analysis was used to compare groups and to determine factors associated with readmission...
February 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29452730/external-validation-of-a-decision-tree-early-warning-score-using-only-laboratory-data-a-retrospective-review-of-prospectively-collected-data
#2
Tara E Holm Atkins, Malin C Öhman, Mikkel Brabrand
INTRODUCTION: Early warning scores (EWS) have been developed to identify the degree of illness severity among acutely ill patients. One system, The Laboratory Decision Tree Early Warning Score (LDT-EWS) is wholly laboratory data based. Laboratory data was used in the development of a rare computerized method, developing a decision tree analysis. This article externally validates LDT-EWS, which is obligatory for an EWS before clinical use. METHOD: We conducted a retrospective review of prospectively collected data based on a time limited sample of all patients admitted through the medical admission unit (MAU) on a Danish secondary hospital...
February 13, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29450552/were-wolves-meet-dermatology
#3
Randy Atkins, Mi Hye Song, Ashley Sturgeon
No abstract text is available yet for this article.
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29448148/large-inter-rater-variability-on-eeg-reactivity-is-improved-by-a-novel-quantitative-method
#4
Christophe Henri Valdemar Duez, Mads Qvist Ebbesen, Krisztina Benedek, Martin Fabricius, Mary Doreen Atkins, Sandor Beniczky, Troels W Kjaer, Hans Kirkegaard, Birger Johnsen
OBJECTIVE: To assess inter-rater agreement on EEG-reactivity (EEG-R) in comatose patients and compare it with a quantitative method (QEEG-R). METHODS: Six 30-s stimulation epochs (noxious, visual and auditory) were performed during EEG on 19 neurosurgical and 11 cardiac arrest patients. Six experts analysed EEGs for reactivity using their habitual methods. QEEG-R was defined as present if ≥2/6 epochs were reactive (stimulation/rest power ratio exceeding noise level)...
February 2, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29442540/management-of-immune-related-adverse-events-in-patients-treated-with-immune-checkpoint-inhibitor-therapy-american-society-of-clinical-oncology-clinical-practice-guideline
#5
Julie R Brahmer, Christina Lacchetti, Bryan J Schneider, Michael B Atkins, Kelly J Brassil, Jeffrey M Caterino, Ian Chau, Marc S Ernstoff, Jennifer M Gardner, Pamela Ginex, Sigrun Hallmeyer, Jennifer Holter Chakrabarty, Natasha B Leighl, Jennifer S Mammen, David F McDermott, Aung Naing, Loretta J Nastoupil, Tanyanika Phillips, Laura D Porter, Igor Puzanov, Cristina A Reichner, Bianca D Santomasso, Carole Seigel, Alexander Spira, Maria E Suarez-Almazor, Yinghong Wang, Jeffrey S Weber, Jedd D Wolchok, John A Thompson
Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process...
February 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29439857/axitinib-in-combination-with-pembrolizumab-in-patients-with-advanced-renal-cell-cancer-a-non-randomised-open-label-dose-finding-and-dose-expansion-phase-1b-trial
#6
Michael B Atkins, Elizabeth R Plimack, Igor Puzanov, Mayer N Fishman, David F McDermott, Daniel C Cho, Ulka Vaishampayan, Saby George, Thomas E Olencki, Jamal C Tarazi, Brad Rosbrook, Kathrine C Fernandez, Mariajose Lechuga, Toni K Choueiri
BACKGROUND: Previous studies combining PD-1 checkpoint inhibitors with tyrosine kinase inhibitors of the VEGF pathway have been characterised by excess toxicity, precluding further development. We hypothesised that axitinib, a more selective VEGF inhibitor than others previously tested, could be combined safely with pembrolizumab (anti-PD-1) and yield antitumour activity in patients with treatment-naive advanced renal cell carcinoma. METHODS: In this ongoing, open-label, phase 1b study, which was done at ten centres in the USA, we enrolled patients aged 18 years or older who had advanced renal cell carcinoma (predominantly clear cell subtype) with their primary tumour resected, and at least one measureable lesion, Eastern Cooperative Oncology Group performance status 0-1, controlled hypertension, and no previous systemic therapy for renal cell carcinoma...
February 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29437406/combined-forward-backward-asymmetry-measurements-in-top-antitop-quark-production-at-the-tevatron
#7
T Aaltonen, V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, S Amerio, D Amidei, A Anastassov, A Annovi, J Antos, G Apollinari, J A Appel, T Arisawa, A Artikov, J Asaadi, W Ashmanskas, A Askew, S Atkins, B Auerbach, K Augsten, A Aurisano, V Aushev, Y Aushev, C Avila, F Azfar, F Badaud, W Badgett, T Bae, L Bagby, B Baldin, D V Bandurin, S Banerjee, A Barbaro-Galtieri, E Barberis, P Baringer, V E Barnes, B A Barnett, P Barria, J F Bartlett, P Bartos, U Bassler, M Bauce, V Bazterra, A Bean, F Bedeschi, M Begalli, S Behari, L Bellantoni, G Bellettini, J Bellinger, D Benjamin, A Beretvas, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, A Bhatti, K R Bland, G Blazey, S Blessing, K Bloom, B Blumenfeld, A Bocci, A Bodek, A Boehnlein, D Boline, E E Boos, G Borissov, D Bortoletto, M Borysova, J Boudreau, A Boveia, A Brandt, O Brandt, L Brigliadori, M Brochmann, R Brock, C Bromberg, A Bross, D Brown, E Brucken, X B Bu, J Budagov, H S Budd, M Buehler, V Buescher, V Bunichev, S Burdin, K Burkett, G Busetto, P Bussey, C P Buszello, P Butti, A Buzatu, A Calamba, E Camacho-Pérez, S Camarda, M Campanelli, F Canelli, B Carls, D Carlsmith, R Carosi, S Carrillo, B Casal, M Casarsa, B C K Casey, H Castilla-Valdez, A Castro, P Catastini, S Caughron, D Cauz, V Cavaliere, A Cerri, L Cerrito, S Chakrabarti, K M Chan, A Chandra, A Chapelain, E Chapon, G Chen, Y C Chen, M Chertok, G Chiarelli, G Chlachidze, K Cho, S W Cho, S Choi, D Chokheli, B Choudhary, S Cihangir, D Claes, A Clark, C Clarke, J Clutter, M E Convery, J Conway, M Cooke, W E Cooper, M Corbo, M Corcoran, M Cordelli, F Couderc, M-C Cousinou, C A Cox, D J Cox, M Cremonesi, D Cruz, J Cuevas, R Culbertson, J Cuth, D Cutts, A Das, N d'Ascenzo, M Datta, G Davies, P de Barbaro, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, L Demortier, M Deninno, D Denisov, S P Denisov, M D'Errico, S Desai, C Deterre, K DeVaughan, F Devoto, A Di Canto, B Di Ruzza, H T Diehl, M Diesburg, P F Ding, J R Dittmann, A Dominguez, S Donati, M D'Onofrio, M Dorigo, A Driutti, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, K Ebina, R Edgar, D Edmunds, A Elagin, J Ellison, V D Elvira, Y Enari, R Erbacher, S Errede, B Esham, H Evans, A Evdokimov, V N Evdokimov, S Farrington, A Fauré, L Feng, T Ferbel, J P Fernández Ramos, F Fiedler, R Field, F Filthaut, W Fisher, H E Fisk, G Flanagan, R Forrest, M Fortner, H Fox, J Franc, M Franklin, J C Freeman, H Frisch, S Fuess, Y Funakoshi, C Galloni, P H Garbincius, A Garcia-Bellido, J A García-González, A F Garfinkel, P Garosi, V Gavrilov, W Geng, C E Gerber, H Gerberich, E Gerchtein, Y Gershtein, S Giagu, V Giakoumopoulou, K Gibson, C M Ginsburg, G Ginther, N Giokaris, P Giromini, V Glagolev, D Glenzinski, O Gogota, M Gold, D Goldin, A Golossanov, G Golovanov, G Gomez, G Gomez-Ceballos, M Goncharov, O González López, I Gorelov, A T Goshaw, K Goulianos, E Gramellini, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, C Grosso-Pilcher, S Grünendahl, M W Grünewald, T Guillemin, J Guimaraes da Costa, G Gutierrez, P Gutierrez, S R Hahn, J Haley, J Y Han, L Han, F Happacher, K Hara, K Harder, M Hare, A Harel, R F Harr, T Harrington-Taber, K Hatakeyama, J M Hauptman, C Hays, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, J Heinrich, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, M Herndon, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, A Hocker, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, Z Hong, W Hopkins, S Hou, I Howley, Z Hubacek, R E Hughes, U Husemann, M Hussein, J Huston, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, G Introzzi, M Iori, A S Ito, A Ivanov, S Jabeen, M Jaffré, E James, D Jang, A Jayasinghe, B Jayatilaka, E J Jeon, M S Jeong, R Jesik, P Jiang, S Jindariani, K Johns, E Johnson, M Johnson, A Jonckheere, M Jones, P Jonsson, K K Joo, J Joshi, S Y Jun, A W Jung, T R Junk, A Juste, E Kajfasz, M Kambeitz, T Kamon, P E Karchin, D Karmanov, A Kasmi, Y Kato, I Katsanos, M Kaur, R Kehoe, S Kermiche, W Ketchum, J Keung, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, B Kilminster, D H Kim, H S Kim, J E Kim, M J Kim, S H Kim, S B Kim, Y J Kim, Y K Kim, N Kimura, M Kirby, I Kiselevich, J M Kohli, K Kondo, D J Kong, J Konigsberg, A V Kotwal, A V Kozelov, J Kraus, M Kreps, J Kroll, M Kruse, T Kuhr, A Kumar, A Kupco, M Kurata, T Kurča, V A Kuzmin, A T Laasanen, S Lammel, S Lammers, M Lancaster, K Lannon, G Latino, P Lebrun, H S Lee, H S Lee, J S Lee, S W Lee, W M Lee, X Lei, J Lellouch, S Leo, S Leone, J D Lewis, D Li, H Li, L Li, Q Z Li, J K Lim, A Limosani, D Lincoln, J Linnemann, V V Lipaev, E Lipeles, R Lipton, A Lister, H Liu, Q Liu, T Liu, Y Liu, A Lobodenko, S Lockwitz, A Loginov, M Lokajicek, R Lopes de Sa, D Lucchesi, A Lucà, J Lueck, P Lujan, P Lukens, R Luna-Garcia, G Lungu, A L Lyon, J Lys, R Lysak, A K A Maciel, R Madar, R Madrak, P Maestro, R Magaña-Villalba, S Malik, S Malik, V L Malyshev, G Manca, A Manousakis-Katsikakis, J Mansour, L Marchese, F Margaroli, P Marino, J Martínez-Ortega, K Matera, M E Mattson, A Mazzacane, P Mazzanti, R McCarthy, C L McGivern, R McNulty, A Mehta, P Mehtala, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, C Mesropian, A Meyer, J Meyer, T Miao, F Miconi, D Mietlicki, A Mitra, H Miyake, S Moed, N Moggi, N K Mondal, C S Moon, R Moore, M J Morello, A Mukherjee, M Mulhearn, Th Muller, P Murat, M Mussini, J Nachtman, Y Nagai, J Naganoma, E Nagy, I Nakano, A Napier, M Narain, R Nayyar, H A Neal, J P Negret, J Nett, P Neustroev, H T Nguyen, T Nigmanov, L Nodulman, S Y Noh, O Norniella, T Nunnemann, L Oakes, S H Oh, Y D Oh, T Okusawa, R Orava, J Orduna, L Ortolan, N Osman, C Pagliarone, A Pal, E Palencia, P Palni, V Papadimitriou, N Parashar, V Parihar, S K Park, W Parker, R Partridge, N Parua, A Patwa, G Pauletta, M Paulini, C Paus, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, T J Phillips, G Piacentino, E Pianori, J Pilot, K Pitts, C Plager, M-A Pleier, V M Podstavkov, L Pondrom, A V Popov, S Poprocki, K Potamianos, A Pranko, M Prewitt, D Price, N Prokopenko, F Prokoshin, F Ptohos, G Punzi, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Redondo Fernández, P Renton, M Rescigno, F Rimondi, I Ripp-Baudot, L Ristori, F Rizatdinova, A Robson, T Rodriguez, S Rolli, M Rominsky, M Ronzani, R Roser, J L Rosner, A Ross, C Royon, P Rubinov, R Ruchti, F Ruffini, A Ruiz, J Russ, V Rusu, G Sajot, W K Sakumoto, Y Sakurai, A Sánchez-Hernández, M P Sanders, L Santi, A S Santos, K Sato, G Savage, V Saveliev, M Savitskyi, A Savoy-Navarro, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, P Schlabach, E E Schmidt, M Schott, C Schwanenberger, T Schwarz, R Schwienhorst, L Scodellaro, F Scuri, S Seidel, Y Seiya, J Sekaric, A Semenov, H Severini, F Sforza, E Shabalina, S Z Shalhout, V Shary, S Shaw, A A Shchukin, T Shears, P F Shepard, M Shimojima, O Shkola, M Shochet, I Shreyber-Tecker, V Simak, A Simonenko, P Skubic, P Slattery, K Sliwa, J R Smith, F D Snider, G R Snow, J Snow, S Snyder, S Söldner-Rembold, H Song, L Sonnenschein, V Sorin, K Soustruznik, R St Denis, M Stancari, J Stark, N Stefaniuk, D Stentz, D A Stoyanova, M Strauss, J Strologas, Y Sudo, A Sukhanov, I Suslov, L Suter, P Svoisky, K Takemasa, Y Takeuchi, J Tang, M Tecchio, P K Teng, J Thom, E Thomson, V Thukral, M Titov, D Toback, S Tokar, V V Tokmenin, K Tollefson, T Tomura, D Tonelli, S Torre, D Torretta, P Totaro, M Trovato, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, F Ukegawa, S Uozumi, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, F Vázquez, G Velev, C Vellidis, A Y Verkheev, C Vernieri, L S Vertogradov, M Verzocchi, M Vesterinen, M Vidal, D Vilanova, R Vilar, J Vizán, M Vogel, P Vokac, G Volpi, P Wagner, H D Wahl, R Wallny, M H L S Wang, S M Wang, J Warchol, D Waters, G Watts, M Wayne, J Weichert, L Welty-Rieger, W C Wester, D Whiteson, A B Wicklund, S Wilbur, H H Williams, M R J Williams, G W Wilson, J S Wilson, P Wilson, B L Winer, P Wittich, M Wobisch, S Wolbers, H Wolfmeister, D R Wood, T Wright, X Wu, Z Wu, T R Wyatt, Y Xie, R Yamada, K Yamamoto, D Yamato, S Yang, T Yang, U K Yang, Y C Yang, W-M Yao, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, G P Yeh, K Yi, H Yin, K Yip, J Yoh, K Yorita, T Yoshida, S W Youn, G B Yu, I Yu, J M Yu, A M Zanetti, Y Zeng, J Zennamo, T G Zhao, B Zhou, C Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic, S Zucchelli
The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of sqrt[s]=1.96  TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A_{FB}^{tt[over ¯]}=0...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29436710/mesophyll-conductance-does-not-contribute-to-greater-photosynthetic-rate-per-unit-nitrogen-in-temperate-compared-with-tropical-evergreen-wet-forest-tree-leaves
#8
Nur H A Bahar, Lucy Hayes, Andrew P Scafaro, Owen K Atkin, John R Evans
Globally, trees originating from high-rainfall tropical regions typically exhibit lower rates of light-saturated net CO 2 assimilation (A) compared with those from high-rainfall temperate environments, when measured at a common temperature. One factor that has been suggested to contribute towards lower rates of A is lower mesophyll conductance. Using a combination of leaf gas exchange and carbon isotope discrimination measurements, we estimated mesophyll conductance (g m ) of several Australian tropical and temperate wet-forest trees, grown in a common environment...
February 13, 2018: New Phytologist
https://www.readbyqxmd.com/read/29428687/changes-in-patellofemoral-pain-resulting-from-repetitive-impact-landings-are-associated-with-the-magnitude-and-rate-of-patellofemoral-joint-loading
#9
Lee T Atkins, C Roger James, Hyung Suk Yang, Phillip S Sizer, Jean-Michel Brismée, Steven F Sawyer, Christopher M Powers
BACKGROUND: Although a relationship between elevated patellofemoral forces and pain has been proposed, it is unknown which joint loading variable (magnitude, rate) is best associated with pain changes. The purpose of this study was to examine associations among patellofemoral joint loading variables and changes in patellofemoral pain across repeated single limb landings. METHODS: Thirty-one females (age: 23.5(2.8) year; height: 166.8(5.8) cm; mass: 59.6(8.1) kg) with PFP performed 5 landing trials from 0...
February 7, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29428085/evaluation-of-genes-associated-with-human-myxomatous-mitral-valve-disease-in-dogs-with-familial-myxomatous-mitral-valve-degeneration
#10
K M Meurs, S G Friedenberg, B Williams, B W Keene, C E Atkins, D Adin, B Aona, T DeFrancesco, S Tou, T Mackay
Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is believed to be heritable in Cavalier King Charles spaniels (CKCS) and Dachshunds. Myxomatous mitral valve disease is a familial disease in human beings as well and genetic mutations have been associated with its development. We hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated with the development of canine MMVD. DNA was isolated from blood samples from 10 CKCS and 10 Dachshunds diagnosed with MMVD, and whole genome sequences from each animal were obtained...
February 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29416571/a-systematic-review-regarding-tonometry-and-the-transmission-of-infectious-diseases
#11
REVIEW
Nicole Atkins, William Hodge, Bruce Li
Tonometry has been identified as a common method for measuring the intraocular pressure in patients. The direct contact between the tonometer and the eye may contribute to the risk of cross infection, especially of viral particles, from one patient to another. A systematic review was undertaken to address the likelihood of human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, and prion diseases transmission through the use of tonometers. Additionally, a comparison of the current tonometer disinfection methods is provided to assist with identifying which technique effectively reduces the risk of disease transmission...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29413797/hip-rotation-during-standing-and-dynamic-activities-and-the-compensatory-effect-of-femoral-anteversion-an-in-vivo-analysis-of-asymptomatic-young-adults-using-three-dimensional-computed-tomography-models-and-dual-fluoroscopy
#12
Keisuke Uemura, Penny R Atkins, Niccolo M Fiorentino, Andrew E Anderson
BACKGROUND: Individuals are thought to compensate for femoral anteversion by altering hip rotation. However, the relationship between hip rotation in a neutral position (i.e. static rotation) and dynamic hip rotation is poorly understood, as is the relationship between anteversion and hip rotation. RESEARCH OBJECTIVE: Herein, anteversion and in-vivo hip rotation during standing, walking, and pivoting were measured in eleven asymptomatic, morphologically normal, young adults using three-dimensional computed tomography models and dual fluoroscopy...
January 29, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29410935/negative-symptom-dimensions-of-the-positive-and-negative-syndrome-scale-across-geographical-regions-implications-for-social-linguistic-and-cultural-consistency
#13
Anzalee Khan, Lora Liharska, Philip D Harvey, Alexandra Atkins, Daniel Ulshen, Richard S E Keefe
Objective: Recognizing the discrete dimensions that underlie negative symptoms in schizophrenia and how these dimensions are understood across localities might result in better understanding and treatment of these symptoms. To this end, the objectives of this study were to 1) identify the Positive and Negative Syndrome Scale negative symptom dimensions of expressive deficits and experiential deficits and 2) analyze performance on these dimensions over 15 geographical regions to determine whether the items defining them manifest similar reliability across these regions...
December 1, 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29409023/erp57-is-protective-against-mutant-sod1-induced-cellular-pathology-in-amyotrophic-lateral-sclerosis
#14
Sonam Parakh, Cyril J Jagaraj, Marta Vidal, Audrey M G Ragagnin, Emma R Perri, Anna Konopka, Reka Toth, Jasmin Galper, Ian P Blair, Colleen J Thomas, Adam K Walker, Shu Yang, Damian M Spencer, Julie D Atkin
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder and mutations in superoxide dismutase1 (SOD1) account for 20% of familial ALS cases. The aetiology of ALS remains unclear, but protein misfolding, endoplasmic reticulum (ER) stress and neuronal apoptosis are implicated. We previously established that protein disulphide isomerase (PDIA1) is protective against ER stress and apoptosis in neuronal cells expressing mutant SOD1, recently mutations in PDIA1 and related PDI family member endoplasmic reticulum protein 57 (ERp57/PDIA), were associated with ALS...
February 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29407157/hybrid-pcl-caco3-scaffolds-with-capabilities-of-carrying-biologically-active-molecules-synthesis-loading-and-in-vivo-applications
#15
M S Saveleva, A N Ivanov, M O Kurtukova, V S Atkin, A G Ivanova, G P Lyubun, A V Martyukova, E I Cherevko, A K Sargsyan, A S Fedonnikov, I A Norkin, A G Skirtach, D A Gorin, B V Parakhonskiy
Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO3) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO3 scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29405860/body-dissatisfaction-neuroticism-and-female-sex-as-predictors-of-calorie-tracking-app-use-amongst-college-students
#16
Kimberly Embacher, Doctoral Student, Rory McGloin, Assistant Professor, David Atkin
No abstract text is available yet for this article.
February 6, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29405608/role-of-prophylactic-azithromycin-to-reduce-airway-inflammation-and-mortality-in-a-rsv-mouse-infection-model
#17
Ricardo A Mosquera, Wilfredo De Jesus-Rojas, James M Stark, Aravind Yadav, Cindy K Jon, Constance L Atkins, Cheryl L Samuels, Traci R Gonzales, Katrina E McBeth, Syed S Hashmi, Roberto Garolalo, Giuseppe N Colasurdo
BACKGROUND: Respiratory syncytial virus (RSV) infection is an important cause of morbidity and mortality in vulnerable populations. Macrolides have received considerable attention for their anti-inflammatory actions beyond their antibacterial effect. We hypothesize that prophylactic azithromycin will be effective in reducing the severity of RSV infection in a mouse model. METHODS: Four groups of BALB/c mice were studied for 8 days: Control (C), RSV-infected (R), early prophylaxis with daily azithromycin from days 1 to 8, (E), and late prophylaxis with daily azithromycin from days 4 to 8 (L)...
February 6, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29396239/long-term-outcomes-of-new-generation-drug-eluting-stents-versus-coronary-artery-bypass-grafting-for-multivessel-and-or-left-main-coronary-artery-disease-a-bayesian-network-meta-analysis-of-randomized-controlled-trials
#18
George S Mina, Hussam Watti, Demiana Soliman, Anand Shewale, Jessica Atkins, Pratap Reddy, Paari Dominic
BACKGROUND: Most data guiding revascularization of multivessel disease (MVD) and/or left main disease (LMD) favor coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI). However, those data are based on trials comparing CABG to bare metal stents (BMS) or old generation drug eluting stents (OG-DES). Hence, it is essential to outcomes of CABG to those of new generation drug eluting stents (NG-DES). METHODS: We searched PUBMED and Cochrane database for trials evaluating revascularization of MVD and/or LMD with CABG and/or PCI...
January 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29396118/clinical-and-cost-effectiveness-of-an-intervention-for-reducing-cholesterol-and-cardiovascular-risk-for-people-with-severe-mental-illness-in-english-primary-care-a-cluster-randomised-controlled-trial
#19
David Osborn, Alexandra Burton, Rachael Hunter, Louise Marston, Lou Atkins, Thomas Barnes, Ruth Blackburn, Thomas Craig, Hazel Gilbert, Samira Heinkel, Richard Holt, Michael King, Susan Michie, Richard Morris, Steve Morris, Irwin Nazareth, Rumana Omar, Irene Petersen, Robert Peveler, Vanessa Pinfold, Kate Walters
BACKGROUND: People with severe mental illnesses, including psychosis, have an increased risk of cardiovascular disease. We aimed to evaluate the effects of a primary care intervention on decreasing total cholesterol concentrations and cardiovascular disease risk in people with severe mental illnesses. METHODS: We did this cluster randomised trial in general practices across England, with general practices as the cluster unit. We randomly assigned general practices (1:1) with 40 or more patients with severe mental illnesses using a computer-generated random sequence with a block size of four...
January 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29386352/stop-codon-readthrough-generates-a-c-terminally-extended-variant-of-the-human-vitamin-d-receptor-with-reduced-calcitriol-response
#20
Gary Loughran, Irwin Jungreis, Ioanna Tzani, Michael Power, Ruslan I Dmitriev, Ivaylo P Ivanov, Manolis Kellis, John F Atkins
Although stop codon readthrough is used extensively by viruses to expand their gene expression, verified instances of mammalian readthrough have only recently been uncovered by systems biology and comparative genomics approaches. Previously our analysis of conserved protein coding signatures that extend beyond annotated stop codons predicted stop codon readthrough of several mammalian genes, all of which have been validated experimentally. Four mRNAs display highly efficient stop codon readthrough, and these mRNAs have a UGA stop codon immediately followed by CUAG (UGA_CUAG) that is conserved throughout vertebrates...
January 31, 2018: Journal of Biological Chemistry
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