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https://www.readbyqxmd.com/read/29691335/novel-insights-into-staphylococcus-aureus-deep-bone-infections-the-involvement-of-osteocytes
#1
Dongqing Yang, Asiri R Wijenayaka, Lucian B Solomon, Stephen M Pederson, David M Findlay, Stephen P Kidd, Gerald J Atkins
Periprosthetic joint infection (PJI) is a potentially devastating complication of orthopedic joint replacement surgery. PJI with associated osteomyelitis is particularly problematic and difficult to cure. Whether viable osteocytes, the predominant cell type in mineralized bone tissue, have a role in these infections is not clear, although their involvement might contribute to the difficulty in detecting and clearing PJI. Here, using Staphylococcus aureus , the most common pathogen in PJI, we demonstrate intracellular infection of human-osteocyte-like cells in vitro and S...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29685887/cardiopulmonary-resuscitation-in-infants-and-children-with-cardiac-disease-a-scientific-statement-from-the-american-heart-association
#2
REVIEW
Bradley S Marino, Sarah Tabbutt, Graeme MacLaren, Mary Fran Hazinski, Ian Adatia, Dianne L Atkins, Paul A Checchia, Allan DeCaen, Ericka L Fink, George M Hoffman, John L Jefferies, Monica Kleinman, Catherine D Krawczeski, Daniel J Licht, Duncan Macrae, Chitra Ravishankar, Ricardo A Samson, Ravi R Thiagarajan, Rune Toms, James Tweddell, Peter C Laussen
Cardiac arrest occurs at a higher rate in children with heart disease than in healthy children. Pediatric basic life support and advanced life support guidelines focus on delivering high-quality resuscitation in children with normal hearts. The complexity and variability in pediatric heart disease pose unique challenges during resuscitation. A writing group appointed by the American Heart Association reviewed the literature addressing resuscitation in children with heart disease. MEDLINE and Google Scholar databases were searched from 1966 to 2015, cross-referencing pediatric heart disease with pertinent resuscitation search terms...
April 23, 2018: Circulation
https://www.readbyqxmd.com/read/29677493/polyamine-control-of-translation-elongation-regulates-start-site-selection-on-antizyme-inhibitor-mrna-via-ribosome-queuing
#3
Ivaylo P Ivanov, Byung-Sik Shin, Gary Loughran, Ioanna Tzani, Sara K Young-Baird, Chune Cao, John F Atkins, Thomas E Dever
Translation initiation is typically restricted to AUG codons, and scanning eukaryotic ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning ribosomes behind a paused elongating ribosome promotes initiation at upstream weak start sites. Ribosomal profiling reveals polyamine-dependent pausing of elongating ribosomes on a conserved Pro-Pro-Trp (PPW) motif in an inhibitory non-AUG-initiated upstream conserved coding region (uCC) of the antizyme inhibitor 1 (AZIN1) mRNA, encoding a regulator of cellular polyamine synthesis...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29667358/human-disease-clinical-medical-sciences-in-dentistry-current-state-and-future-directions-of-undergraduate-teaching-in-the-uk-and-ireland
#4
P A Atkin, S Thomas, R J Cook, M Greenwood, J H Bennett, A Willis, C Donachie, R Ni Riordain, S Galvin, A Crighton, A J Mighell, I Bakri
In March 2017, a group of teachers of human disease/clinical medical science (HD/CMSD) representing the majority of schools from around the UK and Republic of Ireland met to discuss the current state of teaching of human disease and also to discuss how the delivery of this theme might evolve to inform improved healthcare. This study outlines how the original teaching in medicine and surgery to dental undergraduate students has developed into the theme of HD/CMSD reflecting changing needs as well as guidance from the regulators, and how different dental schools have developed their approaches to reach their current state...
April 18, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29660075/acute-medical-risk-scores-is-mars-out-of-this-world
#5
Tara Atkins, Malin Öhman, Tim Cooksley, Mikkel Brabrand
No abstract text is available yet for this article.
April 12, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29659027/perioperative-hematoma-with-subcutaneous-icd-implantation-impact-of-anticoagulation-and-antiplatelet-therapies
#6
Seth H Sheldon, Ryan Cunnane, Madhav Lavu, Valay Parikh, Donita Atkins, Yeruva Madhu Reddy, Loren D Berenbom, Martin P Emert, Rhea Pimentel, Raghuveer Dendi, Dhanunjaya R Lakkireddy
BACKGROUND: The safety of perioperative anticoagulation (AC) and antiplatelet (AP) therapy with subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation is unknown. The purpose of this study was to identify the risk factors associated with hematoma complicating S-ICD implantation. METHODS: Records were retrospectively reviewed from 200 consecutive patients undergoing S-ICD implantation at two academic medical centers. A hematoma was defined as a device site blood accumulation requiring surgical evacuation, extended hospital stay, or transfusion...
April 16, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29650504/interactive-two-way-mhealth-interventions-for-improving-medication-adherence-an-evaluation-using-the-behaviour-change-wheel-framework
#7
Nicole Chiang, Michael Guo, K Rivet Amico, Lou Atkins, Richard T Lester
BACKGROUND: Medication adherence is an important but highly complex set of behaviors, which for life-threatening and infectious diseases such as HIV carry critical consequences for individual and public health. There is growing evidence that mobile phone text messaging interventions (mHealth) connecting providers with patients positively impact medication adherence, particularly two-way engagement platforms that require bidirectional communication versus one-way in which responses are not mandatory...
April 12, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29650059/labyrinthitis-ossificans-in-a-cynomolgus-macaque-macaca-fascicularis
#8
Gayathriy Balamayooran, Hannah M Atkins, Christopher T Whitlow, Samuel T Aycock, Michael A Nader, J Mark Cline, David L Caudell
Labyrinthitis is inflammation of the membranous and bony labyrinth of the inner ear. Typical portals of entry includehematogenous spread from the cochlear vasculature, passage of otitis media pathogens through the round window, and mostcommonly, meningogenic spread from the subarachnoid space. The sequela of chronic inner ear inflammation is labyrinthitisossificans, in which inner ear structures are replaced by fibrous and osseous tissues. Labyrinthitis in humans has been reportedconcurrently with infection due to various viruses (for example, varicella-zoster, measles, mumps) and bacteria (for example,Treponema pallidum, Streptococcus pneumoniae) and may be associated with vertebrobasilar ischemia and meningitis...
April 12, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29648857/associations-of-patient-rated-emotional-bond-and-vocally-encoded-emotional-arousal-among-clinicians-and-acutely-suicidal-military-personnel
#9
Craig J Bryan, Brian R Baucom, Alex O Crenshaw, Zac Imel, David C Atkins, Tracy A Clemans, Bruce Leeson, T Scott Burch, Jim Mintz, M David Rudd
OBJECTIVE: To determine if synchrony in emotional arousal and affective regulation between patients and clinicians reflect emotional bonding during emergency behavioral health appointments. METHOD: Audio recordings of suicide risk assessment interviews and crisis intervention planning with 54 suicidal active duty soldiers presenting to an emergency department or behavioral health clinic were analyzed. Emotional arousal was assessed using mean fundamental frequency...
April 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29626020/bone-and-joint-infection
#10
Julia Colston, Bridget Atkins
Bone and joint infections include septic arthritis, prosthetic joint infections, osteomyelitis, spinal infections (discitis, vertebral osteomyelitis and epidural abscess) and diabetic foot osteomyelitis. All of these may present through the acute medical take. This article discusses the pathogenesis of infection and highlights the importance of taking a careful history and fully examining the patient. It also emphasises the importance of early surgical intervention in many cases. Consideration of alternative diagnoses, appropriate imaging and high-quality microbiological sampling is important to allow appropriate and targeted antimicrobial therapy...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29610880/questionable-conclusions-regarding-blood-pressure-end-points
#11
Anthony Rodgers, Emily Atkins, Abdul Salam
No abstract text is available yet for this article.
April 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29610145/autologous-hematopoietic-stem-cell-transplantation-in-the-treatment-of-multiple-sclerosis
#12
Carolina A Rush, Harold L Atkins, Mark S Freedman
Multiple sclerosis (MS) is an autoimmune disorder that typically affects young people during their most productive years, causing irreversible damage and accumulation of disability. Treatments over time have had modest effects at completely controlling or suppressing disease activity, but are generally aimed at controlling early dominating inflammation that, over time, accumulates damage and leads to progressive disability. Some unfortunate patients are destined to deteriorate despite even newer and more effective agents because of the inability of these drugs to fully curb the inflammatory component of the disease...
April 2, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29606559/the-magnitude-of-translational-and-rotational-head-accelerations-experienced-by-riders-during-downhill-mountain-biking
#13
Howard T Hurst, Stephen Atkins, Ben D Dickinson
OBJECTIVES: To determine the magnitude of translational and rotational head accelerations during downhill mountain biking. DESIGN: Observational study. METHODS: Sixteen male downhill cyclists (age 26.4±8.4years; stature 179.4±7.2cm; mass 75.3±5.9kg) were monitored during two rounds of the British Downhill Series. Riders performed two runs on each course wearing a triaxial accelerometer behind the right ear. The means of the two runs for each course were used to determine differences between courses for mean and maximum peak translational (g) and rotational accelerations (rad/s2 ) and impact duration for each course...
March 21, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29604539/corrigendum-to-changes-in-patellofemoral-pain-resulting-from-repetitive-impact-landings-are-associated-with-the-magnitude-and-rate-of-patellofemoral-joint-loading-clin-biomech-53-2018-31-36
#14
Lee T Atkins, C Roger James, Hyung Suk Yang, Phillip S Sizer, Jean-Michel Brismée, Steven F Sawyer, Christopher M Powers
No abstract text is available yet for this article.
March 28, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29601340/missing-voices-profile-extent-and-12-month-outcomes-of-nonfatal-traumatic-brain-injury-in-aboriginal-and-non-aboriginal-adults-in-western-australia-using-linked-administrative-records
#15
Judith M Katzenellenbogen, Emily Atkins, Sandra C Thompson, Deborah Hersh, Juli Coffin, Leon Flicker, Colleen Hayward, Natalie Ciccone, Deborah Woods, Melanie E Greenland, Meaghan McAllister, Elizabeth M Armstrong
OBJECTIVE: To investigate differences in the profile and outcomes between Aboriginal and non-Aboriginal Western Australians (WAs) hospitalized with traumatic brain injury (TBI). SETTING: WA hospitals. PARTICIPANTS: TBI cases aged 15 to 79 years surviving their first admission during 2002-2011. DESIGN: Patients identified from diagnostic codes and followed up for 12 months or more using WA-wide person-based linked hospital and mortality data...
March 29, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29599095/reported-resuscitation-of-a-hypothermic-avalanche-victim-with-assisted-ventilation-in-1939
#16
Ken Zafren, Dale Atkins, Hermann Brugger
We present a historical case of a 12-year-old boy who survived a reported avalanche burial in 1939 in the Upper Peninsula of Michigan. The boy was completely buried for at least 3 hours, head down, at a depth of about 1 m. He was extricated without signs of life and likely hypothermic by his father, who took him to his home. There, the father performed assisted ventilation for 3 hours using the Schäfer method, a historical method of artificial ventilation, without any specific rewarming efforts. The boy recovered neurologically intact...
March 26, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29595134/intensive-blood-pressure-lowering-reduces-mortality-and-cardiovascular-events-in-older-people
#17
REVIEW
Emily Atkins
No abstract text is available yet for this article.
April 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29587699/use-of-intervention-mapping-to-adapt-a-health-behavior-change-intervention-for-endometrial-cancer-survivors-the-shape-up-following-cancer-treatment-program
#18
Dimitrios A Koutoukidis, Sonia Lopes, Lou Atkins, Helen Croker, M Tish Knobf, Anne Lanceley, Rebecca J Beeken
BACKGROUND: About 80% of endometrial cancer survivors (ECS) are overweight or obese and have sedentary behaviors. Lifestyle behavior interventions are promising for improving dietary and physical activity behaviors, but the constructs associated with their effectiveness are often inadequately reported. The aim of this study was to systematically adapt an evidence-based behavior change program to improve healthy lifestyle behaviors in ECS. METHODS: Following a review of the literature, focus groups and interviews were conducted with ECS (n = 16)...
March 27, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29582037/blood-screen-findings-in-a-2-year-cohort-of-newly-arrived-refugees-to-sydney-australia
#19
Choisung C Ngo, Christine Maidment, Lisa Atkins, Sandy Eagar, Mitchell M Smith
OBJECTIVES: To describe the prevalence of certain health conditions in newly arrived refugees to Sydney, Australia, and thereby help inform screening practices. STUDY TYPE: A clinical audit of routinely collected pathology results. METHODS: Demographics and pathology results from a nurse-led health assessment program for newly arrived refugees during 2013 and 2014 were analysed. Prevalences of screened conditions were calculated, and compared by country of birth and other demographic features...
March 15, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29581235/myeloperoxidase-derived-oxidants-damage-artery-wall-proteins-in-an-animal-model-of-chronic-kidney-disease-accelerated-atherosclerosis
#20
Lixia Zeng, Anna V Mathew, Jaeman Byun, Kevin B Atkins, Frank C Brosius, Subramaniam Pennathur
Increased myeloperoxidase (MPO) levels and activity are associated with increased cardiovascular risk among individuals with chronic kidney disease (CKD). However, a lack of good animal models for examining the presence and catalytic activity of MPO in vascular lesions has impeded mechanistic studies into CKD-associated cardiovascular diseases. Here, we show for the first time that exaggerated atherosclerosis in a pathophysiologically relevant CKD mouse model is associated with increased macrophage-derived MPO activity...
March 26, 2018: Journal of Biological Chemistry
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