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Chen Zhang, Rahul S Patil, Tao Li, Charles L Barnes, Simon J Teat, Jerry L Atwood
Novel supramolecular nanocapsules based on metal-directed assembly have captured tremendous interest due to their applications in fields such as catalysis, selective gas adsorption, and biomedicine. Functionalization of metal-organic nanocapsules (MONCs) by using organic ligands with different pendant groups affords more complexity to the structure and may lead to novel properties. In this work, we report the solvothermal synthesis of a group of magnesium-based MONCs using C-alkylpyrogallol[4]arenes with varying alkyl chain lengths...
June 22, 2017: Chemistry: a European Journal
Stephan Emmrich, Alexandra Streltsov, Franziska Schmidt, Veera Raghavan Thangapandi, Dirk Reinhardt, Jan-Henning Klusmann
BACKGROUND: Long non-coding RNAs (lncRNAs) are recognized as pivotal players during developmental ontogenesis and pathogenesis of cancer. The intronic microRNA (miRNA) clusters miR-99a ~ 125b-2 and miR-100 ~ 125b-1 promote progression of acute megakaryoblastic leukemia (AMKL), an aggressive form of hematologic cancers. The function of the lncRNA hostgenes MIR99AHG (alias MONC) and MIR100HG within this ncRNA ensemble remained elusive. RESULTS: Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts...
2014: Molecular Cancer
Gisèle Montavon, Nicolas Jauquier, Aurélie Coulon, Michel Peuchmaur, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Olivier Delattre, Lukas Sommer, Jean-Marc Joseph, Isabelle Janoueix-Lerosey, Nicole Gross, Annick Mühlethaler-Mottet
The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the oncogenic process. However, the precise role of activating ALK mutations or ALK-wt overexpression in NB tumor initiation needs further clarification. Human ALK-wt, ALK-F1174L, or ALK-R1275Q were stably expressed in murine neural crest progenitor cells (NCPC), MONC-1 or JoMa1, immortalized with v-Myc or Tamoxifen-inducible Myc-ERT, respectively...
June 30, 2014: Oncotarget
Wen-Yan Huang, Weibing Xie, Xia Guo, Fengmin Li, Pedro A Jose, Shi-You Chen
Response gene to complement 32 (RGC-32) is activated by transforming growth factor- β (TGF-β) and plays an important role in smooth muscle cell (SMC) differentiation from neural crest Monc-1 cells. The molecular mechanism governing TGF-β activation of RGC-32, however, remains to be determined. The present studies indicate that TGF-β regulates RGC-32 gene transcription. Sequence analysis revealed a Smad binding element (SBE) located in the region from -1344 to -1337 bp upstream of the transcription start site of RGC-32 gene...
August 2011: American Journal of Physiology. Cell Physiology
Y Dauvilliers, I Arnulf, M-P d'Ortho, A Coste, Ph Ducluzeau, Y Grillet, G Jondeau, R Kessler, L Moncely, P Philip, C Philippe, E Weitzenblum, J-L Pépin
No abstract text is available yet for this article.
October 2010: Revue des Maladies Respiratoires
Sebastián Carranza Lira
INTRODUCTION: Mandibular osteonecrosis (MONC) is an entity associated with the use of powerful bisphosphonates with a prevalence of 1-10% in cancer patients OBJECTIVE: To carry out a literature review with regard MONC, to establish the actual estate of this entity. METHODS: A review of the literature up to September 18, 2007 was done via MEDLINE of the published articles on the topic. They following words were crossed: bisphosphonates, alendronate, clodronic acid, etidronate, ibandronate, risedronate, osteonecrosis, jaw...
November 2007: Ginecología y Obstetricia de México
Fengmin Li, Zaiming Luo, Wenyan Huang, Quansheng Lu, Christopher S Wilcox, Pedro A Jose, Shiyou Chen
We previously developed a robust in vitro model system for vascular smooth muscle cell (VSMC) differentiation from neural crest cell line Monc-1 upon transforming growth factor-beta (TGF-beta) induction. Further studies demonstrated that both Smad and RhoA signaling are critical for TGF-beta-induced VSMC development. To identify downstream targets, we performed Affymetrix cDNA array analysis of Monc-1 cells and identified a gene named response gene to complement 32 (RGC-32) to be important for the VSMC differentiation...
April 6, 2007: Journal of Biological Chemistry
Shiyou Chen, Michelle Crawford, Regina M Day, Victorino R Briones, Jennifer E Leader, Pedro A Jose, Robert J Lechleider
We recently reported that transforming growth factor (TGF)-beta induced the neural crest stem cell line Monc-1 to differentiate into a spindle-like contractile smooth muscle cell (SMC) phenotype and that Smad signaling played an important role in this phenomenon. In addition to Smad signaling, other pathways such as mitogen-activated protein kinase (MAPK), phosphoinositol-3 kinase, and RhoA have also been shown to mediate TGF-beta actions. The objectives of this study were to examine whether these signaling pathways contribute to TGF-beta-induced SMC development and to test whether Smad signaling cross-talks with other pathway(s) during SMC differentiation induced by TGF-beta...
January 20, 2006: Journal of Biological Chemistry
Shiyou Chen, Robert J Lechleider
During vascular development, nascent endothelial networks are invested with a layer of supporting cells called pericytes in capillaries or smooth muscle in larger vessels. The cellular lineage of smooth muscle precursors and factors responsible for regulating their differentiation remain uncertain. In vivo, cells derived from the multipotent neural crest can give rise to vascular smooth muscle in parts of the head and also the cardiac outflow tract. Although transforming growth factor-beta (TGF-beta) has previously been shown to induce some smooth muscle markers from primary cultures of neural crest stem cells, the extent of the differentiation induced was not clear...
May 14, 2004: Circulation Research
Markiyan Oliynyk, Christian B W Stark, Apoorva Bhatt, Michelle A Jones, Zoë A Hughes-Thomas, Christopher Wilkinson, Zoryana Oliynyk, Yuliya Demydchuk, James Staunton, Peter F Leadlay
The analysis of a candidate biosynthetic gene cluster (97 kbp) for the polyether ionophore monensin from Streptomyces cinnamonensis has revealed a modular polyketide synthase composed of eight separate multienzyme subunits housing a total of 12 extension modules, and flanked by numerous other genes for which a plausible function in monensin biosynthesis can be ascribed. Deletion of essentially all these clustered genes specifically abolished monensin production, while overexpression in S. cinnamonensis of the putative pathway-specific regulatory gene monR led to a fivefold increase in monensin production...
September 2003: Molecular Microbiology
Shiyou Chen, Magdalena Kulik, Robert J Lechleider
Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) receptors and regulate transcription of target genes. TGF-beta is implicated in the regulation of the smooth muscle cell specific gene SM22alpha, but little is known about how Smads are involved in SM22alpha gene transcription. In this report, we demonstrate that TGF-beta activation of the SM22alpha promoter is Smad dependent in C3H10T1/2 cells, BALB 3T3 cells and neural crest Monc-1 cells. We find that the promoter region from -162 to +41 is sufficient to up-regulate the reporter gene upon TGF-beta induction...
February 15, 2003: Nucleic Acids Research
Masafumi Watanabe, Matthew D Layne, Chung-Ming Hsieh, Koji Maemura, Susan Gray, Mu-En Lee, Mukesh K Jain
Despite the importance of vascular smooth muscle cells in the regulation of blood vessel function, the molecular mechanisms governing their development and differentiation remain poorly understood. Using an in vitro system whereby a pluripotent neural crest cell line (MONC-1) can be induced to differentiate into smooth muscle cells, we isolated a cDNA fragment that was robustly induced during this differentiation process. Sequence analysis revealed high homology to a partial cDNA termed modulator recognition factor 2 (Mrf2)...
September 6, 2002: Circulation Research
Y H Chen, M D Layne, M Watanabe, S F Yet, M A Perrella
The phenotypic modulation of vascular smooth muscle cells (VSMC) plays a central role in the pathogenesis of arteriosclerosis. Aortic preferentially expressed gene-1 (APEG-1), a VSMC-specific gene, is expressed highly in differentiated but not in dedifferentiated VSMC. Previously, we identified an E-box element in the mouse APEG-1 proximal promoter, which is essential for VSMC reporter activity. In this study, we investigated the role of upstream stimulatory factors (USF) in the regulation of APEG-1 transcription via this E-box element...
December 14, 2001: Journal of Biological Chemistry
C R Berry, E C Hawkins, K J Hurley, K Monce
The purpose of this study was to determine the frequency of hypoxemia and pulmonary mineralization using 99mTc-methylene diphosphonate (99mTc-MDP) in dogs with pituitary-dependent hyperadrenocorticism (PDH). Twenty-one dogs with PDH were prospectively evaluated using thoracic radiography, arterial blood gas analysis, and bone phase and pulmonary perfusion scintigraphy (using 99mTc-macro-aggregated albumin [99mTc-MAA]). The radiographs and bone and perfusion studies were evaluated subjectively. An averaged quantitative count density ratio was calculated between the thorax and cranial thoraco-lumbar vertebrae from lateral thoracic 99mTc-MDP images...
March 2000: Journal of Veterinary Internal Medicine
Freeman, Bryan, Monce
No abstract text is available yet for this article.
July 1, 1992: Physical Review. A
Bryan, Freeman, Monce
No abstract text is available yet for this article.
December 1, 1990: Physical Review. A
No abstract text is available yet for this article.
March 1, 1990: Physical Review. A
No abstract text is available yet for this article.
October 1, 1988: Physical Review. A
No abstract text is available yet for this article.
April 15, 1988: Physical Review. A
No abstract text is available yet for this article.
October 1986: Physical Review. A
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