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https://www.readbyqxmd.com/read/28437840/blood-biomarkers-of-carbohydrate-lipid-and-apolipoprotein-metabolisms-and-risk-of-amyotrophic-lateral-sclerosis-a-more-than-20-year-follow-up-of-the-swedish-amoris-cohort
#1
Daniela Mariosa, Niklas Hammar, Håkan Malmström, Caroline Ingre, Ingmar Jungner, Weimin Ye, Fang Fang, Göran Walldius
Objective To assess the associations of blood biomarkers of carbohydrate, lipid and apolipoprotein metabolisms with the future risk of ALS. Methods In the Apolipoprotein-related MOrtality RISk (AMORIS) study, we enrolled 636,132 men and women during 1985-1996 in Stockholm, Sweden with measurements of serum glucose, total cholesterol, triglycerides, apolipoprotein B (apoB), and apolipoprotein A-I (apoA-I). Serum LDL-C and HDL-C were either directly measured or calculated from total cholesterol, triglycerides and apoA-I...
April 24, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28437766/cyanobacterial-lectins-characteristics-and-their-role-as-antiviral-agents
#2
REVIEW
Ram Sarup Singh, Amandeep Kaur Walia, Jasvirinder Singh Khattar, Davinder Pal Singh, John F Kennedy
Lectins are ubiquitous proteins/glycoproteins of non-immune origin that bind reversibly to carbohydrates in non-covalent and highly specific manner. These lectin-glycan interactions could be exploited for establishment of novel therapeutics, targeting the adherence stage of viruses and thus helpful in eliminating wide spread viral infections. Here the review focuses on the haemagglutination activity, carbohydrate specificity and characteristics of cyanobacterial lectins. Cyanobacterial lectins exhibiting high specificity towards mannose or complex glycans have potential role as anti-viral agents...
April 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28437642/pentoses-and-light-intensity-increase-the-growth-and-carbohydrate-production-and-alter-the-protein-profile-of-chlorella-minutissima
#3
B C B Freitas, A P A Cassuriaga, M G Morais, J A V Costa
High concentrations of carbon, which is considered a necessary element, are required for microalgal growth. Therefore, the identification of alternative carbon sources available in large quantities is increasingly important. This study evaluated the effects of light variation and pentose addition on the carbohydrate content and protein profile of Chlorella minutissima grown in a raceway photobioreactor. The kinetic parameters, carbohydrate content, and protein profile of Chlorella minutissima and its theoretical potential for ethanol production were estimated...
April 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28437263/a-randomised-trial-to-evaluate-preoperative-oral-carbohydrate-administration-on-insulin-resistance-in-off-pump-coronary-artery-bypass-patients
#4
Bora Lee, Sarah Soh, Jae-Kwang Shim, Ha Y Kim, Hyelin Lee, Young-Lan Kwak
BACKGROUND: In fasting cardiac surgery patients, preoperative carbohydrate (CHO) drink intake attenuated insulin resistance and improved cardiac metabolism, although its beneficial effects were not evident after cardiac surgery possibly due to cardiopulmonary bypass-related extreme systemic inflammation. OBJECTIVE: We aimed to evaluate whether preoperative CHO intake affected insulin resistance and free-fatty acid (FFA) concentrations in off-pump coronary revascularisation...
April 21, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28437200/effects-of-dietary-macronutrient-composition-on-fndc5-and-irisin-in-mice-skeletal-muscle
#5
Simone Moreira de Macêdo, Deborah de Farias Lelis, Keila Lopes Mendes, Carlos Alberto de Carvalho Fraga, Igor V Brandi, Jonh David Feltenberger, Lucyana Conceição Farias, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Sérgio Henrique de Sousa Santos
BACKGROUND: Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle Irisin expression and dietary quality. METHODS: Twenty-eight female mice were divided into four groups and fed the following experimental diets for 60 days: standard diet (SD), high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD)...
February 23, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28437190/consuming-a-ketogenic-diet-while-receiving-radiation-and-chemotherapy-for-locally-advanced-lung-cancer-and-pancreatic-cancer-the-university-of-iowa-experience-of-two-phase-1-clinical-trials
#6
Amir Zahra, Melissa A Fath, Emyleigh Opat, Kranti A Mapuskar, Sudershan K Bhatia, Daniel C Ma, Samuel N Rodman Iii, Travis P Snyders, Catherine A Chenard, Julie M Eichenberger-Gilmore, Kellie L Bodeker, Logan Ahmann, Brian J Smith, Sandy A Vollstedt, Heather A Brown, Taher Abu Hejleh, Gerald H Clamon, Daniel J Berg, Luke I Szweda, Douglas R Spitz, John M Buatti, Bryan G Allen
Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative to normal cells, cancer cells are believed to exist under a condition of chronic mitochondrial oxidative stress that is compensated for by increases in glucose metabolism to generate reducing equivalents. In this study we tested the hypothesis that a ketogenic diet concurrent with radiation and chemotherapy would be clinically tolerable in locally advanced non-small cell lung cancer (NSCLC) and pancreatic cancer and could potentially exploit cancer cell oxidative metabolism to improve therapeutic outcomes...
April 24, 2017: Radiation Research
https://www.readbyqxmd.com/read/28436682/kinetics-biochemical-and-factorial-analysis-of-chromium-uptake-in-a-multi-ion-system-by-tradescantia-pallida-rose-d-r-hunt
#7
Vibha Sinha, Kannan Pakshirajan, N Arul Manikandan, Rakhi Chaturvedi
Effluent from electroplating and leather industries is a major concern for the environment due to the presence of chromium (Cr) and other ions, such as sulphate, nitrate, phosphate, etc., which needs to be regulated prior to its discharge into the environment. This study evaluated the potential of Tradescantia pallida, a plant species known for its Cr bioaccumulation, for the simultaneous removal of Cr(6+), SO4(2-), NO3(-) and PO4(3-). Different combination levels of Cr(6+) and the co-ions were planned as per the Plackett-Burman design of experiments performed using hydroponics system...
April 24, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28436597/glycan-analysis-by-ion-mobility-mass-spectrometry
#8
Johanna Hofmann, Kevin Pagel
Carbohydrates form one of the major classes of biological macromolecules in living organisms. To investigate their properties and function, an in-depth knowledge of their underlying structure is essential. However, the inherent structural complexity of glycans represents a major challenge. Carbohydrates are often branched and exhibit diverse regio- and stereochemistry. This in turn leads to a vast number of possible isomers, which are difficult to distinguish using established analytical tools. In the last decade, ion mobility-mass spectrometry, a technique that separates ions based on their mass, charge, size and shape, emerged as a powerful alternative for isomer distinction...
April 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28436589/short-chain-fatty-acids-augment-rat-duodenal-mucosal-barrier-function
#9
Wan Salman Wan Saudi, Markus Sjöblom
Short-chain fatty acids (SCFAs) are produced by bacterial fermentation in the large intestine, particularly from diets containing fibres and carbohydrates. The small intestinal epithelium is exposed to SCFAs derived mainly from oral bacteria or food supplementation. Although luminal nutrients are important in regulation of intestinal functions the role of SCFAs in regulation of small intestinal mucosal barrier function and motility has not been fully described. The aim of the present study was to elucidate the effects of acetate and propionate on duodenal mucosal barrier function and motility...
April 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28436078/oxygen-isotope-fractionations-across-individual-leaf-carbohydrates-in-grass-and-tree-species
#10
Marco M Lehmann, Bruno Gamarra, Ansgar Kahmen, Rolf T W Siegwolf, Matthias Saurer
Almost no δ(18) O data are available for leaf carbohydrates, leaving a gap in the understanding of the δ(18) O relationship between leaf water and cellulose. We measured δ(18) O values of bulk leaf water (δ(18) OLW ) and individual leaf carbohydrates (e.g. fructose, glucose, sucrose) in grass and tree species, and δ(18) O of leaf cellulose in grasses. The grasses were grown under two relative humidity (rH) conditions. Sucrose was generally (18) O-enriched compared to hexoses across all species with an apparent biosynthetic fractionation factor (εbio ) of more than 27‰ relative to δ(18) OLW , which might be explained by isotopic leaf water and sucrose synthesis gradients...
April 23, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28435729/crystal-structure-of-4-nitro-phenyl-6-o-ethyl-%C3%AE-d-galacto-pyran-oside-monohydrate
#11
Bruno Leonardo Silva, Ricardo José Alves, Nivaldo Lúcio Speziali
The synthesis and crystal structure of the title compound, C14H19NO8·H2O, prepared in three steps from 6-O-ethyl-1,2;3,4-di-O-iso-propyl-idene-α-d-galacto-pyran-ose using protecting-group strategies employed in carbohydrate chemistry, is reported. The asymmetric unit consists of a single galactoside mol-ecule, in which the pyran-oid ring has a (4)C1 conformation and the 4-nitro-phenyl moiety is essentially planar. In the crystal, each carbohydrate is surrounded by other d-galactose residues and water mol-ecules, linked by O-H⋯O hydrogen bonds involving all hy-droxy groups, giving a two-dimensional substructure lying parallel to (100) and extended into three dimensions by C-H⋯O inter-actions...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28435686/apple-dwarfing-rootstocks-exhibit-an-imbalance-in-carbohydrate-allocation-and-reduced-cell-growth-and-metabolism
#12
Toshi M Foster, Peter A McAtee, Chethi N Waite, Helen L Boldingh, Tony K McGhie
Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot mass. To identify physiological factors responsible for rootstock-induced growth restriction, we compared vascular-enriched gene expression between two dwarfing rootstocks ('M27' and 'M9') and the vigorous rootstock 'M793' using RNA sequencing and quantitative reverse transcriptase PCR. Differentially expressed genes common to both dwarfing rootstocks belonged to five main biological processes: (1) primary metabolism, (2) cell wall synthesis and modification, (3) secondary metabolism, (4) hormone signalling and response and (5) redox homeostasis...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28435443/occurrence-of-plastidial-triacylglycerol-synthesis-and-the-potential-regulatory-role-of-agpat-in-the-model-diatom-phaeodactylum-tricornutum
#13
Srinivasan Balamurugan, Xiang Wang, Hong-Lei Wang, Chun-Jing An, Hui Li, Da-Wei Li, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li
BACKGROUND: Microalgae have emerged as a potential feedstock for biofuels and bioactive components. However, lack of microalgal strains with promising triacylglycerol (TAG) content and desirable fatty acid composition have hindered its commercial feasibility. Attempts on lipid overproduction by metabolic engineering remain largely challenging in microalgae. RESULTS: In this study, a microalgal 1-acyl-sn-glycerol-3-phosphate acyltransferase designated AGPAT1 was identified in the model diatom Phaeodactylum tricornutum...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28435105/organ-specific-proteomics-of-soybean-seedlings-under-flooding-and-drought-stresses
#14
Xin Wang, Ehsaneh Khodadadi, Baratali Fakheri, Setsuko Komatsu
Organ-specific analyses enrich the understanding of plant growth and development under abiotic stresses. To elucidate the cellular responses in soybean seedlings exposed to flooding and drought stresses, organ-specific analysis was performed using a gel-free/label-free proteomic technique. Physiological analysis indicated that enzyme activities of alcohol dehydrogenase and delta-1-pyrroline-5-carboxylate synthase were markedly increased in leaf and root of plants treated with 6days of flooding and drought stresses, respectively...
April 18, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28434916/the-tetrameric-plant-lectin-banlec-neutralizes-hiv-through-bidentate-binding-to-specific-viral-glycans
#15
Jonathan T S Hopper, Stephen Ambrose, Oliver C Grant, Stefanie A Krumm, Timothy M Allison, Matteo T Degiacomi, Mark D Tully, Laura K Pritchard, Gabriel Ozorowski, Andrew B Ward, Max Crispin, Katie J Doores, Robert J Woods, Justin L P Benesch, Carol V Robinson, Weston B Struwe
Select lectins have powerful anti-viral properties that effectively neutralize HIV-1 by targeting the dense glycan shield on the virus. Here, we reveal the mechanism by which one of the most potent lectins, BanLec, achieves its inhibition. We identify that BanLec recognizes a subset of high-mannose glycans via bidentate interactions spanning the two binding sites present on each BanLec monomer that were previously considered separate carbohydrate recognition domains. We show that both sites are required for high-affinity glycan binding and virus neutralization...
April 17, 2017: Structure
https://www.readbyqxmd.com/read/28434787/integrated-ecotechnology-approach-towards-treatment-of-complex-wastewater-with-simultaneous-bioenergy-production
#16
Manupati Hemalatha, J Shanthi Sravan, Dileep Kumar Yeruva, S Venkata Mohan
Sequential integration of three stage diverse biological processes was studied by exploiting the individual process advantage towards enhanced treatment of complex chemical based wastewater. A successful attempt to integrate sequence batch reactor (SBR) with bioelectrochemical treatment (BET) and finally with microalgae treatment was studied. The sequential integration has showed individual substrate degradation (COD) of 55% in SBR, 49% in BET and 56% in microalgae, accounting for a consolidated treatment efficiency of 90%...
March 22, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28434716/a-bioinformatics-analysis-of-3400-lytic-polysaccharide-oxidases-from-family-aa9
#17
Nicolas Lenfant, Matthieu Hainaut, Nicolas Terrapon, Elodie Drula, Vincent Lombard, Bernard Henrissat
Lytic polysaccharide monooxygenases of family AA9 catalyze the oxidative cleavage of glycosidic bonds in cellulose and related polysaccharides. The N-terminal half of AA9 LPMOs displays a huge sequence variability that is in contradiction with the substrate simplicity so far observed for these enzymes. To understand the cause of the high multigenicity that prevails in the family, we have performed a clustering analysis of the N-terminal region of 3400 sequences of family AA9 LPMOs, and have evaluated the coincidence of the clusters with distal visible features that may accompany functional differences...
April 13, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28434263/plant-protein-based-hydrophobic-fine-and-ultrafine-carrier-particles-in-drug-delivery-systems
#18
Hedieh Malekzad, Hamed Mirshekari, Parham Sahandi Zangabad, S M Moosavi Basri, Fazel Baniasadi, Maryam Sharifi Aghdam, Mahdi Karimi, Michael R Hamblin
For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes...
April 24, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28434208/dietary-interventions-for-adults-with-chronic-kidney-disease
#19
REVIEW
Suetonia C Palmer, Jasjot K Maggo, Katrina L Campbell, Jonathan C Craig, David W Johnson, Bernadet Sutanto, Marinella Ruospo, Allison Tong, Giovanni Fm Strippoli
BACKGROUND: Dietary changes are routinely recommended in people with chronic kidney disease (CKD) on the basis of randomised evidence in the general population and non-randomised studies in CKD that suggest certain healthy eating patterns may prevent cardiovascular events and lower mortality. People who have kidney disease have prioritised dietary modifications as an important treatment uncertainty. OBJECTIVES: This review evaluated the benefits and harms of dietary interventions among adults with CKD including people with end-stage kidney disease (ESKD) treated with dialysis or kidney transplantation...
April 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28433916/a-novel-method-for-contributing-to-composting-start-up-at-low-temperature-by-inoculating-cold-adapted-microbial-consortium
#20
Xin-Yu Xie, Yue Zhao, Qing-Hong Sun, Xue-Qin Wang, Hong-Yang Cui, Xu Zhang, Yan-Jie Li, Zi-Min Wei
Low temperature climate presented a technical challenge to start-up composting in northern region of China. This study investigated if the cold-adapted microbial consortium (CAMC) could promote composting start-up at low temperature. In this work, the CAMC was inoculated when food waste was composted at 10°C. The results showed that inoculating CAMC accelerated the piles temperature effectively, the piles passed through the start-up period within 37h. Moreover, the inoculants could enhance the abundances of dominant strains related to organic matters degradation rate...
April 11, 2017: Bioresource Technology
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