keyword
https://read.qxmd.com/read/37102419/uhplc-quadrupole-exactive-orbitrap-ms-ms-based-putative-identification-for-eucommiae-folium-duzhongye-and-its-quality-marker-candidate-for-pharmacopeia
#21
JOURNAL ARTICLE
Shuqin Liu, Xican Li, Rongxin Cai, Ban Chen, Jingyuan Zeng, Chunhou Li, Xianxi Zhou, Yueying Li
Eucommiae Folium (Duzhongye) is a traditional Chinese medicine with a long history of use in China. However, its quality-marker (Q-marker) in Chinese Pharmacopoeia is poorly defined nowadays. The study therefore conducted an ultra-high-performance liquid chromatography coupled with hybrid quadrupole-orbitrap tandem mass spectrometry (UHPLC-Quadrupole-Exactive-Orbitrap MS/MS) analysis to obtain accurate data. The obtained data were then compared with authentic standards library using Xcalibur 4.1 software package and TraceFinder General Quan...
April 27, 2023: Journal of Separation Science
https://read.qxmd.com/read/36832968/green-solvents-in-the-extraction-of-bioactive-compounds-from-dried-apple-cultivars
#22
JOURNAL ARTICLE
Marcela Hollá, Veronika Pilařová, František Švec, Hana Sklenářová
New extraction protocols, gas-expanded liquid extraction (GXLE), and ultrasound extraction (UE) have been optimized with an emphasis on using green solvents and maximizing the extraction of 14 selected phenolic compounds, including flavonoid-based compounds and phenolic acids from dried apples. The design of the experiments' approach was applied to optimize the main extraction parameters. Fine tuning included optimization of the flow rate in GXLE and the extraction time for GXLE and UE. Optimized GXLE was carried out with CO2 -ethanol-water (34/53...
February 19, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36699116/a-strategy-for-healthy-eating-habits-of-daily-fruits-revisited-a-metabolomics-study
#23
JOURNAL ARTICLE
June Song, Jaesik Jeong, Eun-Hee Kim, Young-Shick Hong
Many people peel fruits, commonly persimmon, grape, apple, and peach, before eating as table fruits. Differences of bioactive compounds between peels and pulps of daily fruits are widely known but limited to individual compound because understanding of differences in their global metabolites is lack. We employed 1 H NMR-based metabolomics to explore the global metabolite differences between their peels and pulps from the fruits, which included changes of diverse metabolites in persimmon after harvest ripening...
2023: Current research in food science
https://read.qxmd.com/read/36677733/chemical-composition-antioxidant-activity-and-cytocompatibility-of-polyphenolic-compounds-extracted-from-food-industry-apple-waste-potential-in-biomedical-application
#24
JOURNAL ARTICLE
Parinaz Hobbi, Oseweuba Valentine Okoro, Maryam Hajiabbas, Masoud Hamidi, Lei Nie, Véronique Megalizzi, Paul Musonge, Gianina Dodi, Amin Shavandi
Apple pomace (AP) from the food industry is a mixture of different fractions containing bioactive polyphenolic compounds. This study provides a systematic approach toward the recovery and evaluation of the physiochemical and biological properties of polyphenolic compounds from AP. We studied subcritical water extraction (SCW) and solvent extraction with ethanol from four different AP fractions of pulp, peel, seed, core, and stem (A), peel (B), seed and core (C), and pulp and peel (D). The subcritical water method at the optimum condition resulted in total polyphenolic compounds (TPC) of 39...
January 9, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36577462/inhibitory-effect-of-quercetin-3-o-%C3%AE-rhamnoside-p-coumaric-acid-phloridzin-and-4-o-%C3%AE-glucopyranosyl-cis-coumaric-acid-on-rats-liver-microsomes-cytochrome-p450-e-activities
#25
JOURNAL ARTICLE
Changyang Ma, Cunyu Liu, Mengjie Ren, Lili Cui, Xuefeng Xi, Wenyi Kang
P-coumaric acid, phloridzin, quercetin-3-O-α-rhamnoside and 4-O-β-glucopyranosyl-cis-coumaric acid isolated in Malus micromalus Makino fruit were investigated the inhibitory activity of cytochrome CYP450 enzyme by the probe test method of rat liver microsomes in vitro, and determined the role in drug metabolism and/or toxicology. Enzymatic kinetics method was used to determine the inhibition type of these components and corresponding inhibition constants. The results demonstrated that all the 4 compounds had no significance to inhibit the activities of CYP2E1 and CYP2C11...
December 25, 2022: Food and Chemical Toxicology
https://read.qxmd.com/read/36557927/dihydrochalcones-in-sweet-tea-biosynthesis-distribution-and-neuroprotection-function
#26
REVIEW
Yong-Kang Wang, Si-Yi Hu, Feng-Yi Xiao, Zhan-Bo Dong, Jian-Hui Ye, Xin-Qiang Zheng, Yue-Rong Liang, Jian-Liang Lu
Sweet tea is a popular herbal drink in southwest China, and it is usually made from the shoots and tender leaves of Lithocarpus litseifolius. The sweet taste is mainly attributed to its high concentration of dihydrochalcones. The distribution and biosynthesis of dihydrochaldones in sweet tea, as well as neuroprotective effects in vitro and in vivo tests, are reviewed in this paper. Dihydrochalones are mainly composed of phloretin and its glycosides, namely, trilobatin and phloridzin, and enriched in tender leaves with significant geographical specificity...
December 12, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36552654/apple-antioxidant-properties-as-an-effect-of-n-dose-and-rate-mycorrhization-involvement-a-long-term-study
#27
JOURNAL ARTICLE
Barbara Łata, Sylwia Żakowska-Biemans, Dariusz Wrona
The genetic and/or the agronomic approaches are two main ways to enhance concentrations of biologically active compounds in fruits and vegetables. In this study, the apple antioxidant status was evaluated from the second to the fourth year after planting in relation to an increasing N-dose applied-with or without plant microbial inoculation in the field conditions. Cultivar 'Šampion Arno' was selected to test these relationships. In the growing season, N treatment and inoculation effects were monitored for the apple peel total phenolics and selected individual phenolic compounds ((+)-catechin, (-)-epicatechin, chlorogenic and caffeic acids, rutin and phloridzin) and total ascorbate concentration...
December 12, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36496617/establishment-of-a-sonotrode-ultrasound-assisted-extraction-of-phenolic-compounds-from-apple-pomace
#28
JOURNAL ARTICLE
María Del Carmen Razola-Díaz, María José Aznar-Ramos, Eduardo Jesús Guerra-Hernández, Belén García-Villanova, Ana María Gómez-Caravaca, Vito Verardo
Apple pomace is the main by-product from apple processing in the juice industry and is considered a source of polyphenols with several health bioactivities. Thus, this research focuses on the establishment of the ultrasound-assisted extraction of total phenolic compounds, focusing on phloretin and phloridzin, with high antioxidant activity from apple pomace, using a sonotrode. We used a Box-Behnken design of 15 experiments with 3 independent factors (ethanol (%), time (min) and amplitude (%)). The responses evaluated were the sum of phenolic compounds, phloretin and phloridzin measured by HPLC-MS-ESI-TOF, and antioxidant activity measured by DPPH, ABTS and FRAP...
November 25, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36479587/gwas-provides-new-insights-into-the-genetic-mechanisms-of-phytochemicals-production-and-red-skin-colour-in-apple
#29
JOURNAL ARTICLE
Satish Kumar, Claire Molloy, Martin Hunt, Cecilia Hong Deng, Claudia Wiedow, Christelle Andre, Andrew Dare, Tony McGhie
Understanding the genetic architecture of apple phytochemicals, and their interplay with conventional selection traits, is critical for the development of new apple cultivars with enhanced health benefits. Apple accessions (n = 344) used for this genome-wide association study (GWAS) represented the wide diversity of metabolic profiles in the domesticated and wild Malus genepools. Fruit samples were phenotyped for 34 metabolites, including a stable vitamin C glycoside "ascorbic acid 2-β-glucoside" (AA-2βG), and the accessions were genotyped using the Apple 20 K SNP Array...
2022: Horticulture Research
https://read.qxmd.com/read/36446937/comparing-the-extraction-methods-chemical-composition-phenolic-contents-and-antioxidant-activity-of-edible-oils-from-cannabis-sativa-and-silybum-marianu-seeds
#30
JOURNAL ARTICLE
Monika Kalinowska, Anna Płońska, Magdalena Trusiak, Ewelina Gołębiewska, Anna Gorlewska-Pietluszenko
In the study the cold-pressed, natural (unfiltered, unrefined) vegetable oils: hemp and milk thistle seed oils were tested for their chemical composition and antioxidant properties. The physico-chemical parameters, content of saturated and unsaturated fatty acids were determined. Solid phase extraction and simple extraction with the use of methanol, ethanol, 80% methanol, 80% ethanol were used to obtain the extracts for the analysis of antioxidant activity and phenolic compounds in oils. The composition of phenolic compounds was studied by means of high-performance liquid chromatography (HPLC-DAD) and spectrophotometric test with the Folin-Ciocalteu reagent...
November 29, 2022: Scientific Reports
https://read.qxmd.com/read/36432076/natural-polyphenol-recovery-from-apple-cereal-and-tomato-processing-by-products-and-related-health-promoting-properties
#31
REVIEW
Katalin Szabo, Laura Mitrea, Lavinia Florina Călinoiu, Bernadette-Emőke Teleky, Gheorghe Adrian Martău, Diana Plamada, Mihaela Stefana Pascuta, Silvia-Amalia Nemeş, Rodica-Anita Varvara, Dan Cristian Vodnar
Polyphenols of plant origin are a broad family of secondary metabolites that range from basic phenolic acids to more complex compounds such as stilbenes, flavonoids, and tannins, all of which have several phenol units in their structure. Considerable health benefits, such as having prebiotic potential and cardio-protective and weight control effects, have been linked to diets based on polyphenol-enriched foods and plant-based products, indicating the potential role of these substances in the prevention or treatment of numerous pathologies...
November 17, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36401738/crispr-cas9-genome-editing-applied-to-mdpgt1-in-apple-results-in-reduced-foliar-phloridzin-without-impacting-plant-growth
#32
JOURNAL ARTICLE
Simón Miranda, Stefano Piazza, Floriana Nuzzo, Mingai Li, Jorge Lagrèze, Axel Mithöfer, Alessandro Cestaro, Danuše Tarkowska, Richard Espley, Andrew Dare, Mickael Malnoy, Stefan Martens
Phloridzin is the most abundant polyphenolic compound in apple (Malus x domestica Borkh.), which results from the action of a key phloretin-specific UDP-2'-O-glucosyltransferase (MdPGT1). Here, we simultaneously assessed the effects of targeting MdPGT1 by conventional transgenesis and CRISPR/Cas9-mediated genome editing. To this end, we conducted transcriptomic and metabolic analyses of MdPGT1 RNAi knockdown and genome-edited lines. Knockdown lines exhibited characteristic impairment of plant growth and leaf morphology, whilst genome-edited lines exhibited normal growth despite reduced foliar phloridzin...
November 19, 2022: Plant Journal
https://read.qxmd.com/read/36383038/a-simple-and-practical-solvent-system-selection-strategy-for-high-speed-countercurrent-chromatography-based-on-the-hplc-polarity-parameter-model
#33
JOURNAL ARTICLE
Xiaohan Zhu, Pengcheng Li, Jintian Tang, Yanqi Su, Mi Xiao, Hongkun Xue, Xu Cai
The selection of an appropriate solvent system is the most crucial step in high-speed countercurrent chromatography (HSCCC) separation. The compound polarity plays an important role in HPLC analysis and HSCCC separation, and it can be calculated by the HPLC polarity parameter model and the average polarity of the HSCCC solvent system, respectively. However, flow rates, columns and methanol concentrations of the HPLC experiment can influence the calculation of the compound polarity. Therefore, the applicability and accuracy of the HPLC polarity parameter model still needed to be extensively validated...
November 16, 2022: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/36365421/effects-of-organic-acid-root-exudates-of-malus-hupehensis-rehd-derived-from-soil-and-root-leaching-liquor-from-orchards-with-apple-replant-disease
#34
JOURNAL ARTICLE
Nan Sun, Chen Yang, Xin Qin, Yangbo Liu, Mengyi Sui, Yawen Zhang, Xueli Cui, Yijun Yin, Rong Wang, Yanli Hu, Xuesen Chen, Zhiquan Mao, Yunfei Mao, Xiang Shen
Organic acids secreted by plants, such as p-hydroxybenzoic acid, ferulic acid, cinnamic acid, and benzoic acid, can inhibit seed germination and root growth. The effects of root and soil leaching liquor from orchards on the growth of M. hupehensis Rehd. seedlings under sand culture are studied; the seedlings are sampled at 15, 30, 45, and 60 d. Changes in the amount of root exudates are determined using HPLC. Low concentrations of root leaching liquor (A1) and soil leaching liquor (B1) significantly promoted plant growth and chlorophyll synthesis; high concentrations of root leaching liquor (A6) and soil leaching liquor (B4-6) inhibited growth...
November 3, 2022: Plants (Basel, Switzerland)
https://read.qxmd.com/read/36312999/optimization-of-the-ultrasound-assisted-extraction-of-flavonoids-and-the-antioxidant-activity-of-ruby-s-apple-peel-using-the-response-surface-method
#35
JOURNAL ARTICLE
NaYeong Park, Sun-Duk Cho, Min-Sun Chang, Gun-Hee Kim
A Box-Behnken Design (BBD) was employed to optimize the extraction of antioxidants from Ruby S apple peel by ultrasound-assisted extraction (UAE). The effect of extraction temperature (20-40 °C), extraction time (15-45 min), and ethanol concentration (50-90%) in water on extraction yield, total phenol content (TPC), total flavonoid content (TFC), and DPPH radical scavenging activity of Ruby S peel extracts (RPEs) were investigated. The optimized extraction conditions that maximized extraction yield, TPC, TFC, and DPPH radical scavenging ability, were temperature 20 °C, extraction time 25...
December 2022: Food Science and Biotechnology
https://read.qxmd.com/read/36303373/comparative-metabolomics-of-himalayan-crab-apple-malus-baccata-with-commercially-utilized-apple-malus-domestica-using-uhplc-qtof-ims-coupled-with-multivariate-analysis
#36
JOURNAL ARTICLE
Vikas Dadwal, Robin Joshi, Mahesh Gupta
A comprehensive UHPLC-QTOF-IMS based metabolomics investigation in skin and pulp of Malus domestica and Malus baccata was performed. M. domestica fruit parts had higher phenolic contents (25.75-43.05 mg GAE/g) as compared to M. baccata (18.10-28.37 mg GAE/g) and flavonoid content (1.34-9.59 mg RE/g) followed by promising antioxidant activity (MD_Skin DPPH 119.41 µg/mL and MB_Skin DPPH 148.24 µg/mL). Targeted metabolomics quantified higher chlorogenic acid in MD_pulp (929.54 mg/100 g) and phloridzin in MD_skin (722...
February 15, 2023: Food Chemistry
https://read.qxmd.com/read/36290719/anti-oxidant-and-anti-aging-effects-of-phlorizin-are-mediated-by-daf-16-induced-stress-response-and-autophagy-in-caenorhabditis-elegans
#37
JOURNAL ARTICLE
Suhyeon Park, Sang-Kyu Park
Phlorizin (phloridzin) is a polyphenolic phytochemical primarily found in unripe Malus (apple). It is a glucoside of phloretin and acts as an inhibitor of renal glucose transport, thus lowering blood glucose. The objective of this study was to determine effects of dietary supplementation with phlorizin on stress response, aging, and age-related diseases using Caenorhabditis elegans as a model system. Survival after oxidative stress or ultraviolet irradiation was significantly increased by pre-treatment of phlorizin...
October 8, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36144202/when-is-the-right-moment-to-pick-blueberries-variation-in-agronomic-and-chemical-properties-of-blueberry-vaccinium-corymbosum-cultivars-at-different-harvest-times
#38
JOURNAL ARTICLE
Miljan Cvetković, Milana Kočić, Dragana Dabić Zagorac, Ivanka Ćirić, Maja Natić, Đurađ Hajder, Aleksandar Životić, Milica Fotirić Akšić
Blueberries, which are recognized by their colored fruits and exquisite flavor and taste, are a great source of bioactive substances with potential functional properties. For the purpose of this study, the blueberry cultivars 'Duke', 'Chandler' and 'Bluecrop' were picked at four different times. The aim of the study was to compare the cultivars and determine the best time for picking fruits for table consumption and to produce berries that can be used as functional foods with elevated levels of bioactive compounds...
August 26, 2022: Metabolites
https://read.qxmd.com/read/36128672/new-bioactive-compounds-characterized-by-liquid-chromatography-mass-spectrometry-and-gas-chromatography-mass-spectrometry-in-hydro-methanol-and-petroleum-ether-extracts-of-prosopis-farcta-banks-sol-j-f-macbr-weed
#39
JOURNAL ARTICLE
Ebrahim Gholamalipour Alamdari, Akram Taleghani
The purpose of this study was to identify and characterize the chemical composition present in aerial parts of Prosopis farcta in petroleum ether and hydro-methanol extracts through LC-PDA-ESI-MS/MS and GC-MS techniques respectively for the first time. The plant samples were collected form northeast of Iran during maturity stage. LC-MS/MS profile revealed 47 phenolic compounds in hydro-methanol extracts, including phenolic acids, flavonoids, and their glycoside derivatives. Flavonoid-O-glycosides (19), flavonoid aglycones (11), phenolic acid derivatives (9), flavonoid-C-glycosides (4), and flavonoid-O, C-glycosides (1) were dominant class phenolics in all studied parts...
September 3, 2022: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/36080123/correction-xie-et-al-preparation-and-characterization-of-new-electrospun-poly-lactic-acid-nanofiber-antioxidative-active-packaging-films-containing-mcm-41-mesoporous-molecular-sieve-loaded-with-phloridzin-and-their-application-in-strawberry-packaging-nanomaterials
#40
Yuan Xie, Guiguang Cheng, Zhoushan Wu, Shang Shi, Jinghao Zhao, Lin Jiang, Dengbang Jiang, Mingwei Yuan, Yudan Wang, Minglong Yuan
In the original publication, there was a mistake in Figure 7, as published in [...].
August 25, 2022: Nanomaterials
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