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Diffuse Low Grade Glioma

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https://www.readbyqxmd.com/read/28079349/interleukin-13-receptor-alpha-2-as-a-marker-of-poorer-prognosis-in-high-grade-astrocytomas
#1
Masahiko Wanibuchi, Yuko Kataoka-Sasaki, Masanori Sasaki, Shinichi Oka, Yayoi Otsuka, Miki Yamaguchi, Hirofumi Ohnishi, Shunya Ohtaki, Shouhei Noshiro, Satoshi Ookawa, Takeshi Mikami, Nobuhiro Mikuni, Osamu Honmou
BACKGROUND: Interleukin-13 receptor alpha 2 (IL13Rα2) is considered a prognostic marker for gliomas according to the World Health Organization (WHO) grade. However, the expression levels of the marker vary from case to case, even within the same grade. We investigated whether IL13Rα2 could serve as a predictor of poorer prognosis in gliomas. METHODS: mRNA expression of IL13Rα2 was measured using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 52 formalin-fixed paraffin-embedded glioma samples (4 pilocytic astrocytomas, 9 diffuse astrocytomas, 12 anaplastic astrocytomas, and 27 glioblastomas, grade IV)...
January 12, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28054416/anomalous-diffusion-in-cerebral-glioma-assessed-using-a-fractional-motion-model
#2
Boyan Xu, Lu Su, Zhenxiong Wang, Yang Fan, Gaolang Gong, Wenzhen Zhu, Peiyi Gao, Jia-Hong Gao
PURPOSE: To demonstrate the capability of the fractional motion (FM) model for describing anomalous diffusion in cerebral gliomas and to assess the potential feasibility of FM for grading these tumors. METHODS: Diffusion MRI images were acquired from brain tumor patients using a special Stejskal-Tanner diffusion sequence with variable diffusion gradient amplitudes and separation times. Patients with histopathologically confirmed gliomas, including astrocytic and oligoastrocytic tumors, were selected...
January 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28039453/comparison-between-ultra-high-and-conventional-mono-b-value-dwi-for-preoperative-glioma-grading
#3
Yu-Chuan Hu, Lin-Feng Yan, Qian Sun, Zhi-Cheng Liu, Shu-Mei Wang, Yu Han, Qiang Tian, Ying-Zhi Sun, Dan-Dan Zheng, Wen Wang, Guang-Bin Cui
To compare the efficacy of ultra-high and conventional mono-b-value DWI for glioma grading, in 109 pathologically confirmed glioma patients, ultra-high apparent diffusion coefficient (ADCuh)was calculated using a tri-exponential mode, distributed diffusion coefficients (DDCs) and α values were calculated using a stretched-exponential model, and conventional ADC values were calculated using a mono-exponential model. The efficacy and reliability of parameters for grading gliomas were investigated using receiver operating characteristic (ROC) curve and intra-class correlation (ICC) analyses, respectively...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030632/contribution-of-1p-19q-9p-and-10q-automated-analysis-by-fish-to-the-diagnosis-and-prognosis-of-oligodendroglial-tumors-according-to-who-2016-guidelines
#4
Karine Michaud, Marie de Tayrac, Myreille D'Astous, Céline Duval, Claudie Paquet, Oumar Samassekou, Peter Vincent Gould, Stéphan Saikali
OBJECTIVE: To study the feasibility and the diagnostic and prognostic interest of automated analysis of 1p, 19q, 9p and 10q status by FISH technique in oligodendroglial tumors. METHODS: We analyzed a retrospective series of 33 consecutive gliomas with oligodendroglial histology (originally diagnosed as 24 oligodendrogliomas and 9 oligoastrocytomas). For all cases, automated FISH analysis of 1p, 19q, 9p and 10q status were performed and compared to clinical and histological data, ATRX, IDH1R132H and alpha-internexin status (studied by immunohistochemistry) and overall survival (OS)...
2016: PloS One
https://www.readbyqxmd.com/read/28010898/the-etiopathogenesis-of-diffuse-low-grade-gliomas
#5
REVIEW
Amélie Darlix, Catherine Gozé, Valérie Rigau, Luc Bauchet, Luc Taillandier, Hugues Duffau
The origins of diffuse low-grade gliomas (DLGG) are unknown. Beyond some limited data on their temporal and cellular origins, the mechanisms and risk factors involved are poorly known. First, based on strong relationships between DLGG development and the eloquence of brain regions frequently invaded by these tumors, we propose a "functional theory" to explain the origin of DLGG. Second, the biological pathways involved in DLGG genesis may differ according to tumor location (anatomo-molecular correlations). The cellular and molecular mechanisms of such "molecular theory" will be reviewed...
January 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27997032/k27m-midline-gliomas-display-malignant-progression-by-imaging-and-histology
#6
Franziska J Vettermann, Julia E Neumann, Bogdana Suchorska, Peter Bartenstein, Armin Giese, Mario M Dorostkar, Nathalie L Albert, Ulrich Schüller
K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV)...
December 20, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27995658/microvascular-proliferation-of-brain-metastases-mimics-glioblastomas-in-squash-cytology
#7
T Gi, Y Sato, T Tokumitsu, A Yamashita, S Moriguchi-Goto, H Takeshima, S Sato, Y Asada
OBJECTIVE: Although microvascular proliferation is a key feature in the diagnosis of high-grade glioma, the characteristics of metastatic tumour vessels in smear preparations have not been documented. In this study, the vascular changes in metastatic brain tumours, using squash cytology to examine the vascular patterns in brain metastases, were reviewed. METHODS: One hundred and forty-three squash smears of brain tissue, including 25 normal or reactive tissue, 23 malignant lymphomas, 8 grade I glioma (pilocytic astrocytoma), 23 grade II glioma (diffuse astrocytoma and oligodendroglioma), 42 grade IV glioma (glioblastoma), and 22 metastasis, were assessed...
December 19, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27978508/targeted-next-generation-sequencing-of-pediatric-neuro-oncology-patients-improves-diagnosis-identifies-pathogenic-germline-mutations-and-directs-targeted-therapy
#8
Cassie N Kline, Nancy M Joseph, James P Grenert, Jessica van Ziffle, Eric Talevich, Courtney Onodera, Mariam Aboian, Soonmee Cha, David R Raleigh, Steve Braunstein, Joseph Torkildson, David Samuel, Michelle Bloomer, Alejandra G de Alba Campomanes, Anuradha Banerjee, Nicholas Butowski, Corey Raffel, Tarik Tihan, Andrew W Bollen, Joanna J Phillips, W Michael Korn, Iwei Yeh, Boris C Bastian, Nalin Gupta, Sabine Mueller, Arie Perry, Theodore Nicolaides, David A Solomon
BACKGROUND: Molecular profiling is revolutionizing cancer diagnostics and leading to personalized therapeutic approaches. Herein we describe our clinical experience performing targeted sequencing for 31 pediatric neuro-oncology patients. METHODS: We sequenced 510 cancer-associated genes from tumor and peripheral blood to identify germline and somatic mutations, structural variants, and copy number changes. RESULTS: Genomic profiling was performed on 31 patients with tumors including 11 high-grade gliomas, 8 medulloblastomas, 6 low-grade gliomas, 1 embryonal tumor with multilayered rosettes, 1 pineoblastoma, 1 uveal ganglioneuroma, 1 choroid plexus carcinoma, 1 chordoma, and 1 high-grade neuroepithelial tumor...
November 14, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27943684/treatment-strategies-for-low-grade-glioma-in-adults
#9
Nancy Ann Oberheim Bush, Susan Chang
Diffuse low-grade gliomas include oligodendrogliomas and astrocytomas. The recent 2016 WHO classification has now updated the definition of these tumors to include molecular characterization, including the presence of isocitrate dehydrogenase mutation and 1p/19q codeletion. In this new classification, the histologic subtype of grade II mixed oligoastrocytoma has been eliminated. Treatment recommendations are currently evolving, mainly because of a change in the prognostic factors that are based on molecular and cytogenetic features...
December 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27893285/recent-advances-in-subtyping-tumors-of-the-central-nervous-system-using-molecular-data
#10
Jens Schittenhelm
Primary brain tumors account for substantial morbidity and mortality. They often infiltrate the brain diffusely, continue growing, and cause adverse events, such as headaches, seizures, and neurological deficits. The classification of primary brain tumors, based for decades on histology, has been fundamentally changed by the World Health Organization in 2016 by incorporation of molecular data. Areas covered: Literature from glioblastomas, high- and low-grade astrocytic, oligodendroglial, glioneuronal and ependymal tumors from the last five years were reviewed...
January 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27888085/high-definition-fiber-tractography-in-evaluation-and-surgical-planning-of-thalamopeduncular-pilocytic-astrocytomas-in-pediatric-population-case-series-and-review-of-literature
#11
Emrah Celtikci, Pinar Celtikci, David Tiago Fernandes-Cabral, Murat Ucar, Juan Carlos Fernandez-Miranda, Alp Ozgun Borcek
OBJECTIVE: Thalamopeduncular tumors (TPTs) of the childhood present a challenge for neurosurgeons due to their eloquent location. Preoperative fiber tracking provides total or near-total resection, without additional neurological deficit. High-definition fiber tractography (HDFT) is an advanced white matter imaging technique derived from magnetic resonance imaging diffusion data, shown to overcome limitation of diffusion tensor imaging. We aimed to investigate alterations of corticospinal tract (CST) and medial lemniscus (ML) caused by TPTs and to demonstrate the application of HDFT in preoperative planning...
November 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27867919/white-matter-change-revealed-by-diffusion-tensor-imaging-in-gliomas
#12
Young Il Won, Chun Kee Chung, Chi Heon Kim, Chul-Kee Park, Bang-Bon Koo, Jong-Min Lee, Hee-Won Jung
BACKGROUND: Tumor-related white matter change is detected at late stages with magnetic resonance imaging (MRI), when mass effect or prominent edema is present. We analyzed if diffusion tensor imaging (DTI) white matter change earlier than conventional MRI. METHODS: Twenty-six patients with gliomas (World Health Organization grade II, 5; grade III, 12; and grade IV, 9) within 2 cm from the posterior limb of the internal capsule (IC) were studied. Fifteen normal adults were enrolled as controls...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27858213/prognostic-relevance-of-gemistocytic-grade-ii-astrocytoma-gemistocytic-component-and-mr-imaging-features-compared-to-non-gemistocytic-grade-ii-astrocytoma
#13
Young Jin Heo, Ji Eun Park, Ho Sung Kim, Ji Ye Lee, Soo Jeong Nam, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
OBJECTIVES: To determine if gemistocytic grade II astrocytoma (GemA) and its MR imaging characteristics are associated with a shorter time-to-progression (TTP) compared with non-gemistocytic grade II astrocytoma (non-GemA). MATERIALS AND METHODS: We enrolled 78 patients who were followed up more than 5 years (29 pathologically proven GemA and 49 non-GemA) during a 10-year period. Contrast-enhanced T1-weighted, diffusion-weighted imaging (DWI), dynamic susceptibility contrast (DSC), and MR spectroscopy (MRS) and clinical data were retrospectively reviewed...
November 17, 2016: European Radiology
https://www.readbyqxmd.com/read/27837437/intra-rater-variability-in-low-grade-glioma-segmentation
#14
Hans Kristian Bø, Ole Solheim, Asgeir Store Jakola, Kjell-Arne Kvistad, Ingerid Reinertsen, Erik Magnus Berntsen
Assessment of size and growth are key radiological factors in low-grade gliomas (LGGs), both for prognostication and treatment evaluation, but the reliability of LGG-segmentation is scarcely studied. With a diffuse and invasive growth pattern, usually without contrast enhancement, these tumors can be difficult to delineate. The aim of this study was to investigate the intra-observer variability in LGG-segmentation for a radiologist without prior segmentation experience. Pre-operative 3D FLAIR images of 23 LGGs were segmented three times in the software 3D Slicer...
November 11, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27834593/an-mrs-and-pet-guided-biopsy-tool-for-intraoperative-neuronavigational-systems
#15
Matthew Grech-Sollars, Babar Vaqas, Gerard Thompson, Tara Barwick, Lesley Honeyfield, Kevin O'Neill, Adam D Waldman
OBJECTIVE Glioma heterogeneity and the limitations of conventional structural MRI for identifying aggressive tumor components can limit the reliability of stereotactic biopsy and, hence, tumor characterization, which is a hurdle for developing and selecting effective treatment strategies. In vivo MR spectroscopy (MRS) and PET enable noninvasive imaging of cellular metabolism relevant to proliferation and can detect regions of more highly active tumor. Here, the authors integrated presurgical PET and MRS with intraoperative neuronavigation to guide surgical biopsy and tumor sampling of brain gliomas with the aim of improving intraoperative tumor-tissue characterization and imaging biomarker validation...
November 11, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27825037/evaluation-of-histopathological-changes-in-the-microstructure-at-the-center-and-periphery-of-glioma-tumors-using-diffusional-kurtosis-imaging
#16
Fuyan Li, Wenqi Shi, Dawei Wang, Yanjie Xu, Hongxia Li, Jingzhen He, Qingshi Zeng
OBJECTIVE: To explore the relationship between alterations in gliomas revealed by diffusional kurtosis imaging (DKI) and the histopathological microstructural changes. METHODS: Thirty-seven patients with cerebral gliomas underwent conventional MRI and DKI at 3.0T. Normalized fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis (MK) were compared in different regions of glioma tumors. Parameters with a high sensitivity and specificity regarding the discrimination of glioma grade were evaluated using receiver operating characteristic (ROC) curve analysis...
October 27, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27780605/idh1-2-gene-hotspot-mutations-in-central-nervous-system-tumours-analysis-of-922-chinese-patients
#17
Ni Chen, Tianpin Yu, Jing Gong, Ling Nie, Xueqin Chen, Mengni Zhang, Miao Xu, Junya Tan, Zhengzheng Su, Jinjing Zhong, Qiao Zhou
Mutations of isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes have been identified as early molecular events in the development of astrocytomas and oligodendrogliomas. Data regarding the status and prevalence of IDH1/2 mutations in Chinese patients are limited. Herein we report our data from West China Hospital, a major Chinese medical centre. IDH1(R132H) mutation was analysed by immunohistochemistry with the mutation-specific IDH1(R132H) antibody in 1011 patients, including 922 central nervous system (CNS) tumours and 89 non-neoplastic CNS lesions, and PCR-based direct sequencing of IDH1/2 gene mutation in 570 of these samples...
December 2016: Pathology
https://www.readbyqxmd.com/read/27776747/dose-dependent-white-matter-damage-after-brain-radiotherapy
#18
Michael Connor, Roshan Karunamuni, Carrie McDonald, Nathan White, Niclas Pettersson, Vitali Moiseenko, Tyler Seibert, Deborah Marshall, Laura Cervino, Hauke Bartsch, Joshua Kuperman, Vyacheslav Murzin, Anitha Krishnan, Nikdokht Farid, Anders Dale, Jona Hattangadi-Gluth
BACKGROUND AND PURPOSE: Brain radiotherapy is limited in part by damage to white matter, contributing to neurocognitive decline. We utilized diffusion tensor imaging (DTI) with multiple b-values (diffusion weightings) to model the dose-dependency and time course of radiation effects on white matter. MATERIALS AND METHODS: Fifteen patients with high-grade gliomas treated with radiotherapy and chemotherapy underwent MRI with DTI prior to radiotherapy, and after months 1, 4-6, and 9-11...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27756661/prosopagnosia-induced-by-a-left-anterior-temporal-lobectomy-following-a-right-temporo-occipital-resection-in-a-multicentric-diffuse-low-grade-glioma
#19
Francesco Corrivetti, Guillaume Herbet, Sylvie Moritz-Gasser, Hugues Duffau
BACKGROUND: Face recognition is a complex function sustained by a distributed large-scale neural network, with a core system involving the ventral occipitotemporal cortex, the inferior longitudinal fasciculus (ILF), and the splenial commissural fibers. This circuit seems to be bilaterally organized, but with a right hemispheric dominance. According to this anatomic functional model, prosopagnosia is usually, but not exclusively, generated by a damage of the right part of this brain network...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27744082/quantitative-diffusion-tensor-imaging-analysis-of-low-grade-gliomas-from-preclinical-application-to-patient-care
#20
Tamara Ius, Luca Turella, Giada Pauletto, Miriam Isola, Marta Maieron, Giovanni Sciacca, Riccardo Budai, Serena D'Agostini, Roberto Eleopra, Miran Skrap
BACKGROUND: Preoperative diffusion tensor tractography (DTT) has recently been used to aid in the mapping of functional pathways to limit damage associated with resection of low-grade gliomas (LGGs). OBJECTIVE: To assess the predictive capacity of DTT as a biomarker of postoperative motor outcomes in patients with LGGs involving the corticospinal tract (CST). CST parameters obtained using a quantitative fiber tracking approach were used to investigate the reliability of the DTT biomarker by comparing their values in the tumoral (Tcst) and healthy (Hcst) hemispheres...
January 2017: World Neurosurgery
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