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MTHFR C677T HCC liver cancer

Paolo Ventura, Giorgia Venturelli, Matteo Marcacci, Massimo Fiorini, Stefano Marchini, Chiara Cuoghi, Antonello Pietrangelo
BACKGROUND: Portal vein thrombosis (PVT) is serious complication of liver cirrhosis (LC), especially in the presence of hepatocellular carcinoma (HCC). The liver plays a key role in homocysteine (Hcy) metabolism: mild hyperhomocysteinemia (HHcy) has been described in LC. HHcy is a risk factor for deep vein thrombosis. Methylen-tetrahydrofolate-reductase (MTHFR) C677T polymorphism is the commonest determinant of mild HHcy and has been involved also in cancer development. AIM: To investigate a possible relation between HHcy, MTHFR status, HCC and PVT in patients affected by LC...
May 2016: Thrombosis Research
Xiaosheng Qi, Xing Sun, Junming Xu, Zhaowen Wang, Jinyan Zhang, Zhihai Peng
Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are considered to have some influence on both folate metabolism and cancer risk. Previous studies on the associations of MTHFR genetic polymorphisms with hepatocellular carcinoma (HCC) risk in Chinese population reported inconsistent results. We performed this meta-analysis to comprehensively assess the associations. Finally, 12 individual case-control studies were included into the meta-analysis. There were seven studies (6,384 subjects) on the MTHFR C677T polymorphism and five studies (4,502 subjects) on the MTHFR A1298C polymorphism...
March 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Fei Jin, Li-Shuai Qu, Xi-Zhong Shen
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate. The non-synonymous single nucleotide polymorphism (nsSNP), C677T (Ala>Val, rs1801133), has been verified to impair enzyme activity. The association with cancer susceptibility, including hepatocellular carcinoma (HCC), has also been widely studied. The results, however, were inconsistent. To shed light on the influence of MTHFR C677T polymorphism on HCC, a meta-analysis was conducted...
2009: Diagnostic Pathology
Carlo Fabris, Pierluigi Toniutto, Edmondo Falleti, Elisabetta Fontanini, Annarosa Cussigh, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Claudio Avellini, Rosalba Minisini, Mario Pirisi
BACKGROUND: A single nucleotide polymorphism (SNP) C677T in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified. The TT or CT genotypes show a marked reduction of the enzyme activity; this causes higher homocysteine levels and alterations of folate metabolism. Folate metabolism is essential for DNA synthesis and methylation, crucial steps in carcinogenesis. In this paper, we investigated whether the MTHFR C677T SNP could influence the occurrence of hepatocellular carcinoma (HCC) in a cohort of patients transplanted for end stage liver disease of different etiologies...
January 2009: Alcoholism, Clinical and Experimental Research
Li-Na Mu, Wei Cao, Zuo-Feng Zhang, Lin Cai, Qing-Wu Jiang, Nai-Chieh You, Binh Yang Goldstein, Guo-Rong Wei, Chuan-Wei Chen, Qing-Yi Lu, Xue-Fu Zhou, Bao-Guo Ding, Jun Chang, Shun-Zhang Yu
OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors...
August 2007: Cancer Causes & Control: CCC
Raphaƫl Saffroy, Patrick Pham, Franck Chiappini, Marine Gross-Goupil, Laurent Castera, Daniel Azoulay, Alain Barrier, Didier Samuel, Brigitte Debuire, Antoinette Lemoine
Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Different polymorphisms have been described for this enzyme, the most studied being the C677T, which has been shown to be associated with predisposition to colorectal cancer in patients who consume a high alcohol diet. The aim of this study was to determine whether the MTHFR polymorphism is related to hepatocellular carcinoma (HCC) in patients with alcoholic cirrhosis...
August 2004: Carcinogenesis
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