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meropenem use evaluation

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https://www.readbyqxmd.com/read/28384185/evaluation-of-a-modified-meropenem-hydrolysis-assay-on-a-large-cohort-of-kpc-and-vim-carbapenemase-producing-enterobacteriaceae
#1
Adriana Calderaro, Mirko Buttrini, Maddalena Piergianni, Sara Montecchini, Monica Martinelli, Silvia Covan, Giovanna Piccolo, Maria Cristina Medici, Maria Cristina Arcangeletti, Carlo Chezzi, Flora De Conto
Carbapenem-resistant Enterobacteriaceae (CRE) have spread globally and represent a serious and growing threat to public health. The introduction of rapid and sensitive methods for the detection of carbapenemase-producing bacteria is of increasing importance. The carbapenemase production can be detected using non-molecular methods (such as the modified Hodge test, the synergy test, the Carba NP test and the antibiotic hydrolysis assays) and DNA-based methods. In this study, we propose a modified version of a previously described meropenem hydrolysis assay (MHA) by MALDI-TOF MS for the phenotypic detection in 2h of carbapenemase-producing Enterobacteriaceae...
2017: PloS One
https://www.readbyqxmd.com/read/28369424/in-vitro-evaluation-of-different-antimicrobial-combinations-against-carbapenemase-producing-klebsiella-pneumoniae-the-activity-of-the-double-carbapenem-regimen-is-related-to-meropenem-mic-value
#2
A Oliva, L Scorzolini, A Cipolla, M T Mascellino, F Cancelli, D Castaldi, A D'Abramo, C D'Agostino, G Russo, M R Ciardi, C M Mastroianni, V Vullo
Objectives and methods: We evaluated the in vitro activity of different antimicrobial combinations with and without colistin against 39 carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains (colistin + meropenem/doripenem, colistin + tigecycline, colistin + rifampicin, gentamicin + meropenem, gentamicin + tigecycline and the double-carbapenem regimen meropenem + ertapenem) using the chequerboard method. The triple combination colistin + meropenem + tigecycline was also tested...
March 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28340557/development-of-selective-medium-for-imp-type-carbapenemase-producing-enterobacteriaceae-in-stool-specimens
#3
Norihisa Yamamoto, Ryuji Kawahara, Yukihiro Akeda, Rathina Kumar Shanmugakani, Hisao Yoshida, Hideharu Hagiya, Naohiro Hara, Isao Nishi, Satomi Yukawa, Rumiko Asada, Yumi Sasaki, Kazuhiro Maeda, Noriko Sakamoto, Shigeyuki Hamada, Kazunori Tomono
BACKGROUND: Identification of carbapenemase-producing Enterobacteriaceae (CPE) in faecal specimens is challenging. This fact is particularly critical because low-level carbapenem-resistant organisms such as IMP-producing CPE are most prevalent in Japan. We developed a modified selective medium more suitable for IMP-type CPE. METHODS: Fifteen reference CPE strains producing different types of β-lactamases were used to evaluate the commercially available CHROMagar KPC and chromID CARBA as well as the newly prepared MC-ECC medium (CHROMagar ECC supplemented with meropenem, cloxacillin, and ZnSO4) and M-ECC medium (CHROMagar ECC supplemented with meropenem and ZnSO4)...
March 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28336136/antimicrobial-susceptibility-of-2906-pseudomonasaeruginosa-clinical-isolates-obtained-from-patients-in-canadian-hospitals-over-a-period-of-8-years-results-of-the-canadian-ward-surveillance-study-canward-2008-2015
#4
Andrew Walkty, Philippe Lagace-Wiens, Heather Adam, Melanie Baxter, James Karlowsky, Michael R Mulvey, Melissa McCracken, George G Zhanel
Pseudomonas aeruginosa is an important nosocomial pathogen. The purpose of this study was to evaluate the antimicrobial susceptibility profile of P. aeruginosa clinical isolates obtained from inpatients and outpatients at hospitals across Canada from January 2008 to December 2015 (CANWARD Study). Susceptibility testing was performed using broth microdilution, as described by the Clinical and Laboratory Standards Institute. In total, 2906 P. aeruginosa isolates were evaluated. The percentage of isolates susceptible to common antipseudomonal antimicrobials was: colistin 94...
January 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28333347/polymyxin-resistant-carbapenem-resistant-acinetobacter-baumannii-is-eradicated-by-a-triple-combination-of-agents-that-lack-individual-activity
#5
Justin R Lenhard, Visanu Thamlikitkul, Fernanda P Silveira, Samira M Garonzik, Xun Tao, Alan Forrest, Beom Soo Shin, Keith S Kaye, Jürgen B Bulitta, Roger L Nation, Jian Li, Brian T Tsuji
Objectives: The emergence of polymyxin resistance threatens to leave clinicians with few options for combatting drug-resistant Acinetobacter baumannii . The objectives of the current investigation were to define the in vitro emergence of polymyxin resistance and identify a combination regimen capable of eradicating A. baumannii with no apparent drug susceptibilities. Methods: Two clonally related, paired, A. baumannii isolates collected from a critically ill patient who developed colistin resistance while receiving colistin methanesulfonate in a clinical population pharmacokinetic study were evaluated: an A...
February 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28288784/development-and-validation-of-a-measurement-procedure-based-on-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simultaneous-measurement-of-%C3%AE-lactam-antibiotic-concentration-in-human-plasma
#6
Raül Rigo-Bonnin, Alba Ribera, Ariadna Arbiol-Roca, Sara Cobo-Sacristán, Ariadna Padullés, Òscar Murillo, Evelyn Shaw, Rosa Granada, Xosé L Pérez-Fernández, Fe Tubau, Pedro Alía
BACKGROUND: The administration of β-lactam antibiotics in continuous infusion could let optimize the pharmacokinetic/pharmacodynamic parameters, especially in the treatment of serious bacterial infections. In this context, and also due to variability in their plasmatic concentrations, therapeutic drug monitoring (TDM) may be useful to optimize dosing and, therefore, be useful for the clinicians. MATERIAL AND METHODS: We developed and validated a measurement procedure based on ultra-high performance liquid chromatography-tandem mass spectrometry for simultaneous measurement of amoxicillin, ampicillin, cloxacillin, piperacillin, cefepime, ceftazidime, cefuroxime, aztreonam and meropenem concentrations in plasma...
March 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28264846/substantial-impact-of-altered-pharmacokinetics-in-critically-ill-patients-on-the-antibacterial-effects-of-meropenem-evaluated-via-the-dynamic-hollow-fiber-infection-model
#7
Phillip J Bergen, Jürgen B Bulitta, Carl M J Kirkpatrick, Kate E Rogers, Megan J McGregor, Steven C Wallis, David L Paterson, Roger L Nation, Jeffrey Lipman, Jason A Roberts, Cornelia B Landersdorfer
Critically ill patients frequently have substantially altered pharmacokinetics compared to non-critically ill patients. We investigated the impact of pharmacokinetic alterations on bacterial killing and resistance for commonly used meropenem dosing regimens. A Pseudomonas aeruginosa isolate (MICmeropenem 0.25 mg/L) was studied in the hollow-fiber infection model (inoculum ∼10(7.5) CFU/mL; 10 days). Pharmacokinetic profiles representing critically ill patients with augmented renal clearance (ARC), normal, or impaired renal function (creatinine clearances of 285, 120 or ∼10 mL/min, respectively) were generated for three meropenem regimens (2g, 1g and 0...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28207768/prevalence-of-mdr-pathogens-of-bacterial-meningitis-in-egypt-and-new-synergistic-antibiotic-combinations
#8
Mona M Abdelkader, Khaled M Aboshanab, Marwa A El-Ashry, Mohammad M Aboulwafa
The aim of this study was identifying bacterial pathogens involved in meningitis, studying their antibiotic resistance profiles, investigating the antibiotic resistance genes as well as evaluating the use of various antibiotic combinations. Antibiotic susceptibility tests were evaluated according to CLSI guidelines. Antibiotic combinations were evaluated by calculating the Fractional Inhibitory Concentration (FIC) index. A total of 71 bacterial isolates were recovered from 68 culture positive CSF specimens...
2017: PloS One
https://www.readbyqxmd.com/read/28203427/potency-of-parenteral-antimicrobials-including-ceftolozane-tazobactam-against-nosocomial-respiratory-tract-pathogens-considerations-for-empiric-and-directed-therapy
#9
Christina A Sutherland, David P Nicolau
BACKGROUND: Empiric therapy decisions are predicated on knowledge of both the epidemiology and antimicrobial susceptibility of the probable infecting pathogen(s). The objective of this study was to evaluate the microbial distribution and phenotypic profiles of nosocomial respiratory isolates collected from multiple US hospitals and assess the clinical utility of various monotherapy and combination regimens. METHODS: Hospitals provided consecutive non-duplicate adult inpatients Gram-negative nosocomial respiratory isolates from cultures received ≥48 h after hospital admission...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28158310/retrospective-and-prospective-evaluation-of-the-carbapenem-inactivation-method-for-the-detection-of-carbapenemase-producing-enterobacteriaceae
#10
Lauraine Gauthier, Remy A Bonnin, Laurent Dortet, Thierry Naas
BACKGROUND: There is an urgent need for accurate and rapid diagnostic tests to identify carbapenemase producing enterobacteria (CPE). Here, we have evaluated the Carbapenem Inactivation Method (CIM) test to detect CPEs from cultured colonies. METHODS: A total of 256 enterobacterial isolates were used to evaluate the performance of the CIM in comparison to Carba NP test and molecular detection used a reference method. Ninety three well-characterized isolates (including 29 non-CPE and 63 CPEs of worldwide origin) with decreased susceptibility to at least one carbapenem were used to (i) evaluate the efficacy of CIM test and (ii) to compare it to the Carba NP test...
2017: PloS One
https://www.readbyqxmd.com/read/28150578/resistotyping-phenotyping-and-genotyping-of-new-delhi-metallo-%C3%AE-lactamase-ndm-among-gram-negative-bacilli-from-iranian-patients
#11
Dariush Shokri, Mohammad Rabbani Khorasgani, Seyed Masih Fatemi, Abbas Soleimani-Delfan
PURPOSE: The purpose of this study was investigation of New Delhi metallo-β-lactamase (NDM) production among gram negative bacilli. METHODOLOGY: Antibiogram-Resistotyping and detection of NDM in clinical isolates of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa and comparative evaluation of the diagnostic performance of three phenotypic methods for NDM detection considering PCR as gold standard were performed. Minimum Inhibitory Concentration (MIC) of antibiotics against NDM positive strains by E-test and clonal relationship analysis using Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR) in these strains were determined...
February 1, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28124968/-accurate-diagnosis-of-pseudomonas-luteola-in-routine-microbiology-laboratory-on-the-occasion-of-two-isolates
#12
Muharrem Çiçek, Gülşen Hasçelik, H Kaan Müştak, K Serdar Diker, Burçin Şener
Pseudomonas luteola which was previously known as Chryseomonas luteola; is a gram-negative, non-fermentative, aerobic, motile, non-spore-forming bacillus. It is frequently found as a saprophyte in soil, water and other damp environments and is an opportunistic pathogen in patients with underlying medical disorders or with indwelling catheters. It has been reported as an uncommon cause of bacteremia, sepsis, septic arthritis, meningitis, endocarditis, and peritonitis. Thus, early and accurate identification of this rare species is important for the treatment and also to provide information about the epidemiology of P...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28124957/-antimicrobial-susceptibility-and-molecular-characterization-of-multidrug-resistant-acinetobacter-baumannii-isolated-in-an-university-hospital
#13
Şahin Direkel, Ayşegül Çopur Çiçek, Alper Karagöz, Nebahat Aydoğan Ejder, Efdal Oktay, Nuran Delialioğlu, Osman Birol Özgümüş, Rıza Durmaz
Acinetobacter baumannii, an aerobic, non-motile, gram-negative bacterium is an important nosocomial pathogen which shows resistance to the most antibiotics. Carbapenems are the most commonly used antibiotics for the treatment of infections caused by this pathogen. However the emergence of resistance against carbapenems in an increasing rate generates serious problems for antimicrobial therapy. The aims of this study were to detect the antibiotic susceptibility, and the presence of blaOXA resistance genes of clinical A...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28124956/-investigation-of-the-frequency-and-distribution-of-beta-lactamase-genes-in-the-clinical-isolates-of-acinetobacter-baumannii-collected-from-different-regions-of-turkey-a-multicenter-study
#14
Fatih Şaban Beriş, Emine Esra Budak, Duygu Gülek, Aytül Uzun, Zeynep Çizmeci, Fırat Zafer Mengeloğlu, Şahin Direkel, Yeliz Çetinkol, Yasemin Ay Altıntop, Meryem Iraz, Tuba Dal, Safiye Umut Say Coşkun, Pervin Özlem Balcı, Tuba Kayman, Ahmet Çalışkan, Yelda Yazıcı, İsmail Tosun, Ayşe Ertürk, Ayşegül Çopur Çiçek
The diversity and distribution of TEM, SHV and CTX-M type of extended-spectrum beta-lactamases (ESBLs) are important for the treatment and control of infections. Determination of ESBL genes in clinical isolates by polymerase chain reaction (PCR) and DNA sequencing can obtain useful data for their molecular epidemiology and risk. The aim of this study was to investigate the frequency of beta-lactamase genes in Acinetobacter baumannii strains isolated from different regions of Turkey. A total of 519 A.baumannii strains collected from hospitals located at 12 different provinces of Turkey (Bolu (n= 67), Tokat (n= 47), Trabzon (n= 25), Ordu (n= 27), Diyarbakır (n= 47), Niğde (n=31), Kayseri (n= 36), Ankara (n= 41), Kirikkale (n= 26), Kahramanmaraş (n= 25), Mersin (n= 40), Istanbul (n= 107)] between 2011-2012 period were included in the study...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28101836/a-review-of-clinical-outcomes-associated-with-two-meropenem-dosing-strategies
#15
REVIEW
Kyle John Wilby, Ziad Ghantous Nasr, Shereen Elazzazy, Tim T Y Lau, Anas Hamad
Meropenem is a carbapenem antibiotic that exhibits time-dependent bactericidal activity, traditionally dosed intravenously at 1 g every 8 h. In order to maximize its pharmacodynamic activity and reduce costs, an alternative regimen employed by many institutions is 500 mg every 6 h. The objective of this review was to summarize and evaluate published literature comparing clinical outcomes associated with these two meropenem dosing regimens. The literature was searched up to October 2016 using the MEDLINE, EMBASE, and Google Scholar databases...
March 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28097722/antimicrobial-utilization-in-an-iraqi-province-a-comprehensive-evaluation-of-antibiotic-source-and-cost
#16
Ali A Al-Jumaili, Ahmed H Hussein, Mohammed D Al-Rekabi, Saba A Raheem, Erika J Ernst
PURPOSE: The aims were to calculate total systemic antibiotic consumption and cost in both public and private sectors in all care settings in Al-Najaf province, Iraq, during 2012, recognize the percentage of each pharmacological class for the dispensed antibiotics and identify oral and parenteral antibiotic percentages dispensed and the portions manufactured nationally and imported. METHODS: Cross-sectional study was conducted in Al-Najaf to calculate the total cost and quantities of antibiotics consumed during 2012 using World Health Organization Guidelines for Defined Daily Dose (DDD)...
February 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28097633/meropenem-dosing-based-on-a-population-pharmacokinetic-pharmacodynamic-model-in-elderly-patients-with-infection-of-the-lower-respiratory-tract
#17
Qing-Tao Zhou, Bei He, Ning Shen, Ying Liang, Li-Na Sun
BACKGROUND: Meropenem is used for the treatment of severe lower respiratory tract infections (LRTIs) caused by multidrug-resistant Gram-negative bacilli. OBJECTIVE: We evaluated the clinical benefits of a strategy of meropenem dosing based on a population pharmacokinetics/pharmacodynamics (PK/PD) model in elderly patients with an LRTI. METHODS: In this prospective single-center open-label randomized controlled trial, 79 elderly patients with an LRTI caused by Gram-negative bacilli were randomized to a study group (SG) or a control group (CG)...
February 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28095794/development-of-an-algorithm-for-phenotypic-screening-of-carbapenemase-producing-enterobacteriaceae-in-the-routine-laboratory
#18
Jérôme Robert, Alix Pantel, Audrey Merens, Elodie Meiller, Jean-Philippe Lavigne, Marie-Hélène Nicolas-Chanoine
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) are difficult to identify among carbapenem non-susceptible Enterobacteriaceae (NSE). We designed phenotypic strategies giving priority to high sensitivity for screening putative CPE before further testing. METHODS: Presence of carbapenemase-encoding genes in ertapenem NSE (MIC > 0.5 mg/l) consecutively isolated in 80 French laboratories between November 2011 and April 2012 was determined by the Check-MDR-CT103 array method...
January 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28079262/pediatric-obesity-pharmacokinetic-alterations-and-effects-on-antimicrobial-dosing
#19
REVIEW
Stephanie Natale, John Bradley, William Huy Nguyen, Tri Tran, Pamela Ny, Kirsten La, Eva Vivian, Jennifer Le
Limited data exist for appropriate drug dosing in obese children. This comprehensive review summarizes pharmacokinetic (PK) alterations that occur with age and obesity, and these effects on antimicrobial dosing. A thorough comparison of different measures of body weight and specific antimicrobial agents including cefazolin, cefepime, ceftazidime, daptomycin, doripenem, gentamicin, linezolid, meropenem, piperacillin-tazobactam, tobramycin, vancomycin, and voriconazole is presented. PubMed (1966-July 2015) and Cochrane Library searches were performed using these key terms: children, pharmacokinetic, obesity, overweight, body mass index, ideal body weight, lean body weight, body composition, and specific antimicrobial drugs...
March 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/27992816/prevalence-and-antimicrobial-susceptibility-of-acinetobacter-spp-isolated-from-meat
#20
Ana Carvalheira, Rocio Casquete, Joana Silva, Paula Teixeira
The prevalence and antibiotic resistance of Acinetobacter spp. from fifty samples of meat (chicken, turkey, beef and pork) were evaluated. Acinetobacter spp. was recovered from all samples and the clonal relatedness of 223 isolates identified to belong to the genus Acinetobacter was established by PFGE. A high genetic diversity was observed and 166 isolates from different samples, 141 representing different PFGE profiles, were further identified to the species level by rpoB gene sequencing. Thirteen distinct Acinetobacter species were identified among 156 isolates...
February 21, 2017: International Journal of Food Microbiology
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