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meropenem use evaluation

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https://www.readbyqxmd.com/read/29649586/nephrotoxicity-of-piperacillin-tazobactam-combined-with-vancomycin-should-it-be-a-concern
#1
Cafer Balcı, Ömrüm Uzun, Mustafa Arıcı, Sibel Aşçıoğlu Hayran, Deniz Yüce, Serhat Ünal
The combination of piperacillin-tazobactam (pip-tazo) and vancomycin provides a wide spectrum of activity against many pathogens acquired in the health-care setting. However, there have been reports of increased potential for nephrotoxicity with this combination. The aim of this study was to evaluate the nephrotoxic effect of pip-tazo plus vancomycin and compare it with that of pip-tazo and vancomycin alone, and meropenem plus vancomycin, another broad-spectrum combination. A total of 402 patients receiving either antimicrobial regimen for more than 48 hours were evaluated retrospectively in a two-year period...
April 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29625943/drug-utilization-and-prescribing-pattern-of-antibiotics-in-a-tertiary-care-setups-trends-and-practices
#2
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29615167/pseudomonas-aeruginosa-evaluation-of-pathogen-burden-and-drug-resistance-trends-in-a-tertiary-care-hospital
#3
Muhammad Saeed, Farhan Rasheed, Raja Kamran Afzal, Shahida Hussain, Saba Riaz, Adeel Ahmad
OBJECTIVE: To evaluate the pathogen burden and antibiotic-resistance trends of Pseudomonas aeruginosa among hospitalised patients at a tertiary care hospital. STUDY DESIGN: Retrospective, hospital record-based, cross-sectional study. PLACE AND DURATION OF STUDY: Microbiology Laboratory, Allama Iqbal Medical College/Jinnah Hospital, Lahore, from January 2014 to December 2016. METHODOLOGY: A total of 5,960 samples were collected from clinically suspected cases of bacterial infections, admitted to the hospital...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29596216/reduction-of-inappropriate-antimicrobial-prescriptions-in-a-tertiary-neonatal-intensive-care-unit-following-antimicrobial-stewardship-care-bundle-implementation
#4
Joseph Y Ting, Vanessa Paquette, Karen Ng, Sarka Lisonkova, Valoria Hait, Sandesh Shivanada, Peter Tilley, Osiovich Horacio, Ashley Roberts
BACKGROUND: Our objective was to evaluate the appropriateness of antibiotic prescriptions in the neonatal intensive care unit (NICU) using standardised criteria and determine the effects of an antimicrobial stewardship programme (ASP) on patterns of antibiotic usage. METHODS: A retrospective audit of antibiotic use from July 2010-June 2013 was conducted, focusing on prescriptions of vancomycin, cefotaxime, meropenem and linezolid for >3 calendar days. We evaluated the appropriateness of each course of antibiotic treatment based on the Centers for Disease Control and Prevention (CDC) 12-Step Guidelines to Prevent Antimicrobial Resistance (Steps 4, 6 and 9)...
March 24, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29579106/impact-of-nutritional-stress-on-drug-susceptibility-and-biofilm-structures-of-burkholderia-pseudomallei-and-burkholderia-thailandensis-grown-in-static-and-microfluidic-systems
#5
Chitchanok Anutrakunchai, Jan G M Bolscher, Bastiaan P Krom, Sakawrat Kanthawong, Sorujsiri Chareonsudjai, Suwimol Taweechaisupapong
Burkholderia pseudomallei is the causative agent of melioidosis and regarded as a bioterrorism threat. It can adapt to the nutrient-limited environment as the bacteria can survive in triple distilled water for 16 years. Moreover, B. pseudomallei exhibits intrinsic resistance to diverse groups of antibiotics in particular while growing in biofilms. Recently, nutrient-limited condition influenced both biofilm formation and ceftazidime (CAZ) tolerance of B. pseudomallei were found. However, there is no information about how nutrient-limitation together with antibiotics used in melioidosis treatment affects the structure of the biofilm produced by B...
2018: PloS One
https://www.readbyqxmd.com/read/29561258/in-vitro-evaluation-of-double-carbapenem-combinations-against-oxa-48-producing-klebsiella-pneumoniae-isolates-using-time-kill-studies
#6
Irene Galani, Konstantina Nafplioti, Marianthi Chatzikonstantinou, Maria Souli
PURPOSE: The aim of this study was to evaluate the in vitro activity of double-carbapenem combinations against OXA-48-producing Klebsiella pneumoniae clinical isolates. METHODOLOGY: Double combinations of ertapenem, meropenem and imipenem were evaluated for synergy and bactericidal activity using the time-kill methodology. All antibiotics were tested at 10 mg l-1 and at a sub-inhibitory concentration of 0.5× minimum inhibitory concentration (MIC) for isolates with a carbapenem MIC≤8 mg l-1 ...
March 21, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29548877/antibiotic-consumption-versus-the-prevalence-of-multidrug-resistant-acinetobacter-baumannii-and-clostridium-difficile-infections-at-an-icu-from-2014-2015
#7
Grzegorz Ziółkowski, Iwona Pawłowska, Lech Krawczyk, Jadwiga Wojkowska-Mach
BACKGROUND: Acinetobacter baumannii strains are currently the most commonly isolated non-fermenting rods at Polish intensive care units (ICUs), and they are the dominant aetiological agents of pneumonia. This study aimed to evaluate the prevalence of A. baumannii isolated from patients who were hospitalised at Sosnowiec Hospital's ICU. We also investigated the drug sensitivity of A. baumannii in relation to antibiotic consumption expressed as the defined daily dose (DDD) and Clostridium difficile infection (CDI)...
March 13, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29548525/evaluation-of-the-carbapenem-detection-set%C3%A2-for-the-detection-and-characterization-of-carbapenemase-producing-enterobacteriaceae
#8
Laurent Dortet, Sandrine Bernabeu, Camille Gonzalez, Thierry Naas
The objective of this study was to assess the performance of the Carbapenemase Detection Set™ (CDS; Mast Diagnostics) in association with i) the EUCAST meropenem screening cut-off and ii) the faropenem-temocillin algorithm (FTa) for the screening of carbapenemase-producing Enterobacteriaceae (CPE). A total of 200 well-characterized enterobacterial isolates with reduced susceptibility to at least one carbapenem including 63 non-CPEs and 137 CPEs belonging to different Ambler classes were initially screened for CPEs using i) the EUCAST meropenem cut-off (diameter <25 mm) and ii) the FTa...
February 17, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29548009/duration-of-exposure-to-multiple-antibiotics-is-associated-with-increased-risk-of-vre-bacteraemia-a-nested-case-control-study
#9
Theodore Gouliouris, Ben Warne, Edward J P Cartwright, Luke Bedford, Chathika K Weerasuriya, Kathy E Raven, Nick M Brown, M Estée Török, Direk Limmathurotsakul, Sharon J Peacock
Background: VRE bacteraemia has a high mortality and continues to defy control. Antibiotic risk factors for VRE bacteraemia have not been adequately defined. We aimed to determine the risk factors for VRE bacteraemia focusing on duration of antibiotic exposure. Methods: A retrospective matched nested case-control study was conducted amongst hospitalized patients at Cambridge University Hospitals NHS Foundation Trust (CUH) from 1 January 2006 to 31 December 2012...
March 13, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29530848/population-pharmacokinetics-of-meropenem-in-plasma-and-subcutis-in-patients-on-extracorporeal-membrane-oxygenation-treatment
#10
Pelle Hanberg, Kristina Öbrink-Hansen, Anders Thorsted, Mats Bue, Mikkel Tøttrup, Lena E Friberg, Tore Forsingdal Hardlei, Kjeld Søballe, Jakob Gjedsted
The objectives of this study were to describe meropenem pharmacokinetics (PK) in plasma and/or subcutaneous adipose tissue (SCT) in critically ill patients receiving ECMO treatment, and to develop a population PK model to simulate alternative dosing regimens and modes of administration. We conducted a prospective observational study. Ten patients on ECMO treatment received meropenem (1 or 2 g) intravenously over 5 min every 8 hours. Serial SCT concentrations were determined using microdialysis and compared with plasma concentrations...
March 12, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29530842/evaluation-of-ceftolozane-tazobactam-in-combination-with-meropenem-against-pseudomonas-aeruginosa-st175-in-a-hollow-fiber-infection-model
#11
M Montero, Brian D VanScoy, Carla López-Causapé, Haley Conde, Jonathan Adams, Concepción Segura, Laura Zamorano, Antonio Oliver, Juan P Horcajada, Paul G Ambrose
The aim of this study was to investigate the efficacy of ceftolozane-tazobactam in combination with meropenem against an extensively drug-resistant (XDR) Pseudomonas aeruginosa high-risk clone, ST175, isolated in a Spanish university hospital. A 14-day hollow-fiber infection model was used to simulate clinical exposure of the 2 drug regimens alone and in combination, and serial samples were collected to determine drug concentrations and colony-forming unit (CFU) counts. The untreated control failed, as did each study regimen when administered alone...
March 12, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29527202/comprehensive-evaluation-of-the-mbt-star-bl-module-for-simultaneous-bacterial-identification-and-%C3%AE-lactamase-mediated-resistance-detection-in-gram-negative-rods-from-cultured-isolates-and-positive-blood-cultures
#12
Annie W T Lee, Johnson K S Lam, Ricky K W Lam, Wan H Ng, Ella N L Lee, Vicky T Y Lee, Po P Sze, Rahim Rajwani, Kitty S C Fung, Wing K To, Rodney A Lee, Dominic N C Tsang, Gilman K H Siu
Objective: This study evaluated the capability of a MALDI Biotyper system equipped with the newly introduced MBT STAR-BL module to simultaneously perform species identification and β-lactamase-mediated resistance detection in bacteremia -causing bacteria isolated from cultured isolates and patient-derived blood cultures (BCs). Methods: Two hundred retrospective cultured isolates and 153 prospective BCs containing Gram-negative rods (GNR) were collected and subjected to direct bacterial identification, followed by the measurement of β-lactamase activities against ampicillin, piperacillin, cefotaxime, ceftazidime, and meropenem using the MBT STAR-BL module...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29525799/determination-of-antibiotic-resistance-pattern-and-prevalence-of-oxa-type-carbapenemases-among-acinetobacter-baumannii-clinical-isolates-from-inpatients-in-isfahan-central-iran
#13
Aliakbar Rezaei, Hossein Fazeli, Mehdi Moghadampour, Mehrdad Halaji, Jamshid Faghri
Acinetobacter baumannii is one of the most important bacterial species with the ability to produce OXA-type carbapenemases. We aimed to evaluate the prevalence of OXA-type carbapenemases among clinical isolates of A. baumannii in three major hospitals of Isfahan. In this cross-sectional descriptive study, 153 non-repeated strains of A. baumannii were isolated from various clinical samples of hospitalized patients in Al-Zahra, Imam Mousa Kazem, and Shariati hospitals from October 2015 to October 2016. Antimicrobial susceptibility testing for imipenem, meropenem, ertapenem, cefepime, ceftazidime, ceftriaxone, piperacillin-tazobactam, gentamicin, amikacin, ciprofloxacin, and tetracycline was performed using the disk diffusion method...
March 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29514462/meropenem-vaborbactam-the-first-carbapenem-%C3%AE-lactamase-inhibitor-combination
#14
Jonathan C Cho, Monika T Zmarlicka, Kristy M Shaeer, Joe Pardo
OBJECTIVE: To review the pharmacology, spectrum of activity, pharmacokinetics, pharmacodynamics, safety, efficacy, administration, and considerations for clinical use of meropenem/vaborbactam (M/V). DATA SOURCES: A literature search using PubMed and clinicaltrials.gov (June 2013 to December 2017) was conducted using the search terms meropenem, vaborbactam, RPX7009, biapenem, RPX2003, and carbavance. References from relevant articles and conference abstracts were also reviewed...
March 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29510189/in-vitro-activity-of-meropenem-vaborbactam-and-characterization-of-carbapenem-resistance-mechanisms-among-carbapenem-resistant-enterobacteriaceae-from-the-2015-meropenem-vaborbactam-surveillance-program
#15
Michael A Pfaller, Michael D Huband, Rodrigo E Mendes, Robert K Flamm, Mariana Castanheira
We evaluated meropenem-vaborbactam activity against 11,559 Enterobacteriaceae isolates, including 330 carbapenem-resistant phenotypes (CRE) and carbapenemase genotypes collected worldwide during 2015. Meropenem-vaborbactam (inhibitor at 8 mg/L) and comparators were susceptibility tested using reference broth microdilution methods. CRE isolates were screened for the presence of genes encoding carbapenemases and 292 (88.5%) of the CRE isolates carried these resistance genes. A total of 209 (63.3% of the CRE; 1...
March 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29498795/antibiotic-resistance-evolution-of-pseudomonas-aeruginosa-in-cystic-fibrosis-patients-2010-2013
#16
Francesca Lucca, Margherita Guarnieri, Mirco Ros, Giovanna Muffato, Roberto Rigoli, Liviana Da Dalt
INTRODUCTION: Pseudomonas aeruginosa is the predominant pathogen responsible of chronic colonization of the airways in Cystic Fibrosis patients. There are few European data about antibiotic susceptibility evolution of Pseudomonas aeruginosa in Cystic Fibrosis patients. OBJECTIVES: The aim of this study is to evaluate the evolution of antibiotic resistance in the period 2010-2013 in Cystic Fibrosis patients chronically colonized by Pseudomonas aeruginosa and to highlight the characteristics of this evolution in patients younger than 20 years...
March 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29474142/occurrence-genotyping-and-antibiotic-susceptibility-of-cronobacter-spp-in-drinking-water-and-food-samples-from-northeast-china
#17
Peng Fei, Yichao Jiang, Shaoying Gong, Ran Li, Yan Jiang, Xiujuan Yuan, Ziyuan Wang, Huaibin Kang, Md Aslam Ali
Cronobacter species (formerly Enterobacter sakazakii) are emerging opportunistic bacterial pathogens that can infect both infants and adults. This study was conducted to isolate and genotype diverse Cronobacter species from drinking water, chilled fresh pork, powdered infant formula, instant noodles, cookies, fruits, vegetables, and dishes in Northeast China and to evaluate the antibiotic resistance and susceptibility of the isolates. Thirty-four Cronobacter strains were isolated and identified: 21 C. sakazakii isolates (61...
February 23, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29472508/false-prolongation-of-international-normalized-ratio-associated-with-daptomycin
#18
Susan E Smith, Kelli A Rumbaugh
PURPOSE: Persistent elevation of prothrombin time (PT) and International Normalized Ratio (INR) values in a patient receiving daptomycin is reported. SUMMARY: A morbidly obese 51-year-old man was hospitalized for evaluation for surgical intervention for gallstone pancreatitis and biliary obstruction. Previously prescribed warfarin therapy was withheld due to suspected coagulopathy and an elevated INR (5.1), and warfarin reversal was initiated. After undergoing partial cholecystectomy on hospital day 6, the patient developed sepsis and was treated with i...
March 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29444829/multiplex-immunochromatographic-detection-of-oxa-48-kpc-and-ndm-carbapenemases-impact-of-the-inoculum-antibiotics-and-agar
#19
Ahmad Saleh, Stephan Göttig, Axel Hamprecht
SYNOPSIS For rapid detection of carbapenemase-producing Enterobacteriaceae (CPE), immunochromatographic lateral flow tests (ICT) have recently been developed. The aim of this study was to assess the new multiplex ICT RESIST-3 O.K.N®. and to investigate if it can be performed directly from susceptibility testing plates. Additionally the impact of the inoculum and carbapenem disks on sensitivity and specificity was evaluated. The new ICT was challenged using 63 CRE isolates, including 51 carbapenemase producers...
February 14, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29441876/evaluation-of-antimicrobial-stewardship-as-for-appropriate-use-of-antimicrobial-agents
#20
T Matsuoka, M Kato, Y Shinoda, K Ohashi, S Yoshida, T Mori, T Tachi, T Yoshimura, H Teramachi
We implemented an antimicrobial stewardship (AS) program whereby pharmacists sought appropriate use of antimicrobial agents in January 2012. At that time, we targeted anti-methicillin-resistant Staphylococcus aureus (MRSA) agents and carbapenems; however, in January 2014, we added tazobactam/piperacillin (TAZ/PIPC). We evaluated outcomes using multilateral analyses. The average one-day dosage of carbapenems increased; however, the duration of administration and number of recipient patients decreased significantly (P < 0...
May 1, 2017: Die Pharmazie
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