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meropenem use evaluation

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https://www.readbyqxmd.com/read/30244038/carbapenem-resistant-pseudomonas-aeruginosa-carrying-bla-vim-36-assigned-as-st308-indicated-non-virulence-in-g-mellonella-model
#1
Patrícia R Neves, Lauro Vieira Perdigão Neto, Roberta Cristina Ruedas Martins, Jéssica F Ramos, Gleice Leite, Flavia Rossi, Sabri Saeed Sanabani, Vanderson Rocha, Marjorie Vieira Batista, Thais Guimaraes, Anna S Levin, Sílvia F Costa
OBJECTIVES: Based on pulsed field gel electrophoresis profile, whole genome sequencing (WGS) of 8 CarbR P. aeruginosa strains from a bone marrow transplant unit, in São Paulo, Brazil, was carried out to investigate which resistance and virulence genes are present as well as determine the multilocus sequence types (ST). METHODS: Initial susceptible pattern was obtained by Vitek 2. Minimal inhibitory concentrations (MICs) were determined by broth microdilution for amikacin, meropenem and colistin...
September 20, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/30219312/the-effects-of-antibiotic-type-and-extender-storage-method-on-sperm-quality-and-antibacterial-effectiveness-in-fresh-and-cooled-stored-stallion-semen
#2
C Hernández-Avilés, R Serafini, C C Love, S R Teague, K A LaCaze, S D Lawhon, J Wu, T L Blanchard, D D Varner
Two experiments were conducted to evaluate the effects of antibiotic-containing extender of on sperm quality and control of bacterial growth. In Experiment 1, ejaculates were diluted in extender containing no antibiotics, potassium penicillin G-amikacin disulfate (PEN-AMIK), ticarcillin disodium-potassium clavulanate (TICAR-CLAV), piperacillin sodium/tazobactam sodium (PIP-TAZ), or meropenem (MERO). In freshly extended semen, only slight differences were detected among some antibiotic treatments for total sperm motility, curvilinear velocity, and viable acrosome-intact sperm (P < 0...
August 28, 2018: Theriogenology
https://www.readbyqxmd.com/read/30214255/comparison-of-five-commonly-used-automated-susceptibility-testing-methods-for-accuracy-in-the-china-antimicrobial-resistance-surveillance-system-carss-hospitals
#3
Menglan Zhou, Yao Wang, Chang Liu, Timothy Kudinha, Xiaolin Liu, Yanping Luo, Qiwen Yang, Hongli Sun, Jihong Hu, Ying-Chun Xu
Objective: The objective of this study was to evaluate the performance of five commonly used automated antimicrobial susceptibility testing (AST) systems in China (Vitek 2, Phoenix, Microscan, TDR, and DL). Materials and methods: Two "unknown" isolates, S1 (ESBL-producing Escherichia coli ) and S2 (KPC-producing Klebsiella pneumoniae ), were sent to 886 hospitals in China for identification and AST. Using broth microdilution method (BMD) as gold standard, minimum inhibitory concentrations (MICs) were determined...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30214088/comparison-of-twice-a-day-and-three-times-a-day-meropenem-administration-in-elderly-patients-in-a-japanese-community-hospital
#4
Kouji Aimiya, Takayoshi Mamiya, Katsunori Tabuchi, Toshiyuki Kita, Masayuki Hiramatsu
Meropenem (MEPM) is a broad-spectrum antibiotic prescribed to patients with moderate or severe pneumonia. It is well recognized that appropriate medicine reduces the burden on not only young patients but elderly ones as well. We enrolled 56 patients aged 75 and over who were diagnosed with moderate or severe pneumonia (body temperature: ≧37.5 °C; white blood cell (WBC) count: ≧10,000/μL; C-reactive protein (CRP): ≧4 mg/dL) on the basis of Clinical Evaluation Methods for New Antimicrobial Agents to Treat Respiratory Infections defined by the Japanese Society of Chemotherapy, at the National Hospital Organization Kanazawa Medical Center from January 1, 2007 to May 31, 2010...
August 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/30197524/carbapenem-resistant-acinetobacter-baumannii-and-pseudomonas-aeruginosa-characterization-of-carbapenemase-genes-and-e-test-evaluation-of-colistin-based-combinations
#5
Raghdaa A Ramadan, Manar G Gebriel, Heba M Kadry, Ahmed Mosallem
Background: Carbapenamase producing Acinetobacter baumannii and Pseudomonas aeruginosa are emerging worldwide limiting the use of carbapenems as effective and safe drugs. Purpose: To characterize different carbapenemase genes carried by carbapenem-resistant (CR) A. baumannii and P. aeruginosa isolates and to evaluate the in vitro effect of some colistin-based combinations by E-test method in Zagazig University Hospitals ICU isolates. Methods: CR A...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30197092/impact-of-carbapenem-versus-non-carbapenem-treatment-on-the-rates-of-superinfection-a-meta-analysis-of-randomized-controlled-trials
#6
Khalid Eljaaly, Mushira A Enani, Jaffar A Al-Tawfiq
Imipenem and meropenem are the recommended antipseudomonal carbapenems for nosocomial pneumonia per clinical practice guidelines. However, these agents have a relatively broader spectrum of activity than other antibiotics and need to be reserved. Carbapenems might cause higher rate of superinfection. The aim of this study was to compare the rate of superinfection between patients who received imipenem or meropenem versus those who received non-carbapenem treatment. PubMed, EMBASE, Cochrane Library databases and two trial registries were searched for relevant randomized controlled trials of hospitalized adults with pneumonia through February 24, 2017 without date or language restrictions...
September 6, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30175410/incidence-of-acute-kidney-injury-among-patients-receiving-the-combination-of-vancomycin-with-piperacillin-tazobactam-or-meropenem
#7
Amy D Robertson, Chenghui Li, Drayton Hammond, Tiffany A Dickey
INTRODUCTION: Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). There is conflicting evidence regarding the risk of AKI when VAN is combined with an anti-pseudomonal beta-lactam. OBJECTIVES: To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or meropenem (MER). METHODS: This was a retrospective cohort study of acutely ill adults receiving the combination of VAN and PTZ or MER for at least 48 hours between November 1, 2014 and October 31, 2016 in a tertiary care hospital...
September 2, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30172957/study-of-the-spread-of-antimicrobial-resistant-enterobacteriaceae-from-wild-mammals-in-the-national-park-of-aspromonte-calabria-italy
#8
Maria Foti, Antonino Siclari, Antonietta Mascetti, Vittorio Fisichella
Antimicrobial-resistant (AMR) bacteria are a threat to global health. Epidemiological studies are necessary to gain a more detailed understanding of the transmission modality of resistant bacteria to wild animals and their diffusion into the environment to ensure a broader evaluation of the epidemiological role of wildlife. The study aimed to identify little-known epidemiological aspects by focusing on the isolation of Enterobacteriaceae in order to bring knowledge on the bacterial flora of wild mammals living in the National Park of Aspromonte (Calabria, Italy)...
August 28, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/30155456/synergy-between-proline-rich-antimicrobial-peptides-and-small-molecule-antibiotics-against-selected-gram-negative-pathogens-in-vitro-and-in-vivo
#9
Laszlo Otvos, Eszter Ostorhazi, Dora Szabo, Steven D Zumbrun, Lynda L Miller, Stephanie A Halasohoris, Puvi D Desai, Sharon M Int Veldt, Carl N Kraus
As monotherapy, modified proline-rich antimicrobial peptides (PrAMPs) protect animals from experimental bacteremia in a dose-dependent manner. We evaluated the in vitro synergy of a modified PrAMP, A3-APO, a dimer, previously shown to inhibit the 70 kDa bacterial heat shock protein DnaK, with imipenem or colistin against two antibiotic-resistant pathogens; a carbapenemase-expressing Klebsiella pneumoniae strain K97/09 and Acinetobacter baumannii (ATCC BAA-1605). Combining antimicrobials resulted in synergy for PrAMP/colistin combination against both K...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/30137377/therapeutic-drug-monitoring-of-%C3%AE-lactam-antibiotics-in-the-critically-ill-direct-measurement-of-unbound-drug-concentrations-to-achieve-appropriate-drug-exposures
#10
Gloria Wong, Scott Briscoe, Brett McWhinney, Mumtaz Ally, Jacobus Ungerer, Jeffrey Lipman, Jason A Roberts
Objectives: To describe the achievement of unbound β-lactam antibiotic concentration targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the factors associated with failure to achieve a target concentration. Patients and methods: Plasma samples and clinical data were obtained for analysis from a single centre prospectively. Unbound concentrations of ceftriaxone, cefazolin, meropenem, ampicillin, benzylpenicillin, flucloxacillin and piperacillin were directly measured using ultracentrifugation...
August 17, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30127628/optimal-infusion-rate-in-antimicrobial-therapy-explosion-of-evidence-in-the-last-five-years
#11
REVIEW
Ling-Ling Zhu, Quan Zhou
Background: Sporadic studies in antimicrobial therapy have evaluated the effects of infusion rates on therapeutic and economic outcomes, and new findings may challenge the regular infusion regimen. Methods: Focusing on studies comparing the outcomes of different infusion regimens, the relevant literature was identified by searching PubMed, Web of Science, and Scopus from January 1, 2013 to March 1, 2018. Papers were finally chosen using a PRISMA flowchart. Results: Antimicrobials with the superiority of prolonged infusion to standard infusion in terms of efficacy and safety include meropenem, doripenem, imipenem, cefepime, ceftazidime, piperacillin/tazobactam, linezolid, and vancomycin...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30120647/an-evaluation-of-risk-factors-to-predict-target-concentration-non-attainment-in-critically-ill-patients-prior-to-empiric-%C3%AE-lactam-therapy
#12
Sahand Imani, Hergen Buscher, Richard Day, Sheridan Gentili, Graham R D Jones, Debbie Marriott, Ross Norris, Indy Sandaradura
To determine whether target concentration non-attainment can be anticipated in critically ill patients prior to initiating empiric β-lactam antibiotic therapy based on readily available clinical factors. Retrospective review of consecutive patients treated with piperacillin or meropenem and who underwent therapeutic drug monitoring (TDM) at St Vincent's Hospital (Sydney, Australia) between January 2013 and December 2015 was performed. Predefined subgroups were patients who received continuous renal replacement therapy (CRRT) and those who did not (non-CRRT)...
August 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30112996/n-sulfamoylbenzoyl-l-proline-derivatives-as-potential-non-%C3%AE-lactam-esbl-inhibitors-structure-based-lead-identification-medicinal-chemistry-and-synergistic-antibacterial-activities
#13
Xinyu Liu, Shengjie Dong, Yuru Ma, Hu Xu, Hongxia Zhao, Qingzhi Gao
BACKGROUND: There is an urgent need to develop novel inhibitors against clinically widespread extended-spectrum β-lactamases (ESBLs) to meet the challenges of the ever-evolving threat of antibiotic resistances. Most existing ESBL inhibitors sharing a common chemical feature of β-lactam ring in their molecule, this structural characteristic makes them intrinsically susceptible to enzymatic breakdown by the resistance mechanisms employed by the bacteria. OBJECTIVE: The aim of this study was to screen and discover novel lead compounds by using L-proline as initial scaffold to create a "non-sulfur, non-β-lactam" new chemotypes for potential ESBL inhibitors...
August 16, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/30106599/pharmacokinetic-evaluation-of-meropenem-and-vaborbactam-for-the-treatment-of-urinary-tract-infection
#14
Rodrigo M Burgos, Mark J Biagi, Keith A Rodvold, Larry H Danziger
Meropenem/vaborbactam (M/V) represents the first carbapenem and β-lactamase inhibitor combination approved for treatment of complicated urinary tract infections (cUTIs), including pyelonephritis. Vaborbactam is a novel boronic acid, β-lactamase inhibitor with a high affinity for serine β-lactamases, including Klebsiella pneumoniae carbapenemase (KPC). This combination, Vabomere™, was approved in August 2017 by the United States Food and Drug Administration for the treatment of cUTIs in patients 18 years or older, including pyelonephritis, caused by the following susceptible microorganisms: Escherichia coli, K...
September 19, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/30093392/rapid-direct-susceptibility-testing-from-positive-blood-cultures-by-the-maldi-tof-ms-based-direct-on-target-microdroplet-growth-assay
#15
Evgeny A Idelevich, Luise M Storck, Katrin Sparbier, Oliver Drews, Markus Kostrzewa, Karsten Becker
Recently developed direct-on-target microdroplet growth assay (DOT-MGA) allows rapid universal antimicrobial susceptibility testing (AST) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Here, we investigated direct application of this method on positive blood cultures (BC) for acceleration of sepsis diagnostics. Blood samples spiked with meropenem-non-susceptible and meropenem-susceptible Enterobacterales isolates were inoculated into BACTEC Plus Aerobic/F bottles and incubated in the BACTEC automated system...
August 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30087007/the-exploration-of-population-pharmacokinetic-model-for-meropenem-in-augmented-renal-clearance-and-investigation-of-optimum-setting-of-dose
#16
Tatsuro Tamatsukuri, Masayuki Ohbayashi, Noriko Kohyama, Yasuna Kobayashi, Toshinori Yamamoto, Kenichiro Fukuda, Shunsuke Nakamura, Yasufumi Miyake, Kenji Dohi, Mari Kogo
In recent years, augmented renal clearance (ARC), in which renal function is excessively enhanced, has been reported, and its influence on β-lactam antibiotics has been investigated. In this study, we aimed to determine the optimum population pharmacokinetic model of meropenem in patients with sepsis with ARC, and evaluated dosing regimens based on renal function. Seventeen subjects (6 with ARC and 11 without) were enrolled in this study. Predicted meropenem concentrations were evaluated for bias and precision using the Bland-Altman method...
October 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30078964/clinical-and-laboratory-standards-institute-versus-european-committee-for-antimicrobial-susceptibility-testing-guidelines-for-interpretation-of-carbapenem-antimicrobial-susceptibility-results-for-escherichia-coli-in-urinary-tract-infection-uti
#17
Chinmoy Sahu, Vidhi Jain, Prabhakar Mishra, Kashi Nath Prasad
BACKGROUND: Carbapenems show excellent activity against resistant uropathogens, and they are the antibiotics of choice for urinary tract infections (UTIs). The choice of carbapenem prescription is strongly influenced by antimicrobial susceptibility testing (AST) report. With the publication of recent AST guidelines by the European Committee on AST (EUCAST), we were curious to evaluate the difference in results between Clinical and Laboratory Standards Institute (CLSI) and the EUCAST guidelines for the interpretation of carbapenems...
July 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/30067146/variability-in-the-adaptive-response-of-antibiotic-resistant-salmonella-typhimurium-to-environmental-stresses
#18
Md Jalal Uddin, Gibeom Jeon, Juhee Ahn
This study was designed to evaluate the resistance phenotype and genotype of wild type (WT)-, cefotaxime (CET)-, and ciprofloxacin (CIP)-induced Salmonella Typhimurium ATCC 19585, CIP-resistant Salmonella Typhimurium ATCC 19585, Salmonella Typhimurium CCARM 8009, and Salmonella Typhimurium KCCM 40253 before and after exposure to pH 4.5, 4% NaCl, and heat at 42°C. The susceptibilities of WT Salmonella Typhimurium ATCC 19585 and WT Salmonella Typhimurium KCCM 40253 to all antibiotics tested in this study were decreased after CET and CIP induction with the exception with kanamycin, meropenem, and polymyxin B...
August 1, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30063465/prevalence-and-antibiotic-utilization-pattern-of-uropathogens-causing-community-acquired-urinary-tract-infection-in-kerala-india
#19
Dilip Chandrasekhar, Athira Dollychan, Bincy Mary Roy, Shinu Cholamughath, Jaffer Chalil Parambil
BACKGROUND: A prospective observational study was carried out over a period of 6 months among the inpatients and outpatients in the departments of general medicine, urology, obstetrics, and gynecology of a tertiary level referral hospital in south Malabar region of Kerala to assess the prevalence of various bacterial isolates and their changing susceptibility to antimicrobial agents and to evaluate the pattern of antibiotic utilization in urinary tract infection (UTI). METHODS: A total of 680 samples were analyzed from December 2015 to May 2016; among them, only 74 patients met the inclusion criteria...
July 31, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30059536/clinical-outcomes-of-prolonged-infusion-extended-infusion-or-continuous-infusion-versus-intermittent-bolus-of-meropenem-in-severe-infection-a-meta-analysis
#20
Zhenwei Yu, Xiaoping Pang, Xuqi Wu, Chunlei Shan, Saiping Jiang
BACKGROUND: Meropenem exhibits time-dependent antimicrobial activity and prolonged infusion (PI) (extended infusion or continuous infusion, EI or CI) of meropenem can better achieve pharmacodynamics target when comparing with intermittent bolus (IB). However, the clinical outcomes between two groups remain inconclusive. OBJECTIVE: To evaluate current published literatures by meta-analysis to ascertain whether PI of meropenem can improve clinical outcomes. METHODS: Medline, Cochrane database and EMBASE were searched...
2018: PloS One
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