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https://www.readbyqxmd.com/read/27777573/artery-tertiary-lymphoid-organs-powerhouses-of-atherosclerosis-immunity
#1
Changjun Yin, Sarajo Kumar Mohanta, Prasad Srikakulapu, Christian Weber, Andreas J R Habenicht
Artery tertiary lymphoid organs (ATLOs) are atherosclerosis-associated lymphoid aggregates with varying degrees of complexity ranging from small T/B-cell clusters to well-structured lymph node-like though unencapsulated lymphoid tissues. ATLOs arise in the connective tissue that surrounds diseased arteries, i.e., the adventitia. ATLOs have been identified in aged atherosclerosis-prone hyperlipidemic apolipoprotein E-deficient (ApoE(-/-)) mice: they are organized into distinct immune cell compartments, including separate T-cell areas, activated B-cell follicles, and plasma cell niches...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27102965/artery-tertiary-lymphoid-organs-control-multilayered-territorialized-atherosclerosis-b-cell-responses-in-aged-apoe-mice
#2
Prasad Srikakulapu, Desheng Hu, Changjun Yin, Sarajo K Mohanta, Sai Vineela Bontha, Li Peng, Michael Beer, Christian Weber, Coleen A McNamara, Gianluca Grassia, Pasquale Maffia, Rudolf A Manz, Andreas J R Habenicht
OBJECTIVE: Explore aorta B-cell immunity in aged apolipoprotein E-deficient (ApoE(-/-)) mice. APPROACH AND RESULTS: Transcript maps, fluorescence-activated cell sorting, immunofluorescence analyses, cell transfers, and Ig-ELISPOT (enzyme-linked immunospot) assays showed multilayered atherosclerosis B-cell responses in artery tertiary lymphoid organs (ATLOs). Aging-associated aorta B-cell-related transcriptomes were identified, and transcript atlases revealed highly territorialized B-cell responses in ATLOs versus atherosclerotic lesions: ATLOs showed upregulation of bona fide B-cell genes, including Cd19, Ms4a1 (Cd20), Cd79a/b, and Ighm although intima plaques preferentially expressed molecules involved in non-B effector responses toward B-cell-derived mediators, that is, Fcgr3 (Cd16), Fcer1g (Cd23), and the C1q family...
June 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27098405/ectopic-expression-of-cxcl13-baff-april-and-lt-%C3%AE-is-associated-with-artery-tertiary-lymphoid-organs-in-giant-cell-arteritis
#3
Francesco Ciccia, Aroldo Rizzo, Rosario Maugeri, Riccardo Alessandro, Stefania Croci, Giuliana Guggino, Alberto Cavazza, Stefania Raimondo, Alessandra Cannizzaro, Domenico Gerardo Iacopino, Carlo Salvarani, Giovanni Triolo
OBJECTIVES: To investigate whether artery tertiary lymphoid organs (ATLOs) are present in giant cell arteritis (GCA) and that their formation is associated with the ectopic expression of constitutive lymphoid tissue-homing chemokines. METHODS: Reverse transcriptase PCR, immunohistochemical and immunofluorescence analysis were used to determine the presence of ectopic ATLOs in GCA and the expression of chemokines/chemokine receptors and cytokines involved in lymphoneogenesis in the temporal artery samples obtained from 50 patients with GCA and 30 controls...
April 20, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26663606/developing-students-clinical-reasoning-skills-correlates-of-perceived-relevance-of-two-teaching-and-learning-approaches
#4
T C Postma, J G White
INTRODUCTION: 'Relevance' is a key concept in adult learning. Hence, this study sought to examine students' perceptions of relevance of the teaching and learning in relation to different instructional designs employed in a Comprehensive Patient Care (CPC) course that aims to develop integrated clinical reasoning skills. METHODS: Third to fifth year students (2009-2011) were asked to anonymously rate the relevance of the instructional design (RELID) they participated in by means of visual analogue scales at the School of Dentistry, University of Pretoria...
December 10, 2015: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/26445797/generation-of-aorta-transcript-atlases-of-wild-type-and-apolipoprotein-e-null-mice-by-laser-capture-microdissection-based-mrna-expression-microarrays
#5
Changjun Yin, Sarajo Mohanta, Zhe Ma, Christian Weber, Desheng Hu, Falk Weih, Andreas Habenicht
Atherosclerosis is a transmural chronic inflammatory disease of medium and large arteries. Though it is well recognized that immune responses contribute to atherosclerosis, it remains unclear whether these responses are carried out in secondary lymphoid organs such as the spleen and lymph nodes and/or within the arterial wall. Arteries are composed of three major layers, i.e., the laminae intima, media, and adventitia. However, each of these layers may play different roles in arterial wall biology and atherogenesis...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26084025/artery-tertiary-lymphoid-organs-control-aorta-immunity-and-protect-against-atherosclerosis-via-vascular-smooth-muscle-cell-lymphotoxin-%C3%AE-receptors
#6
Desheng Hu, Sarajo K Mohanta, Changjun Yin, Li Peng, Zhe Ma, Prasad Srikakulapu, Gianluca Grassia, Neil MacRitchie, Gary Dever, Peter Gordon, Francis L Burton, Armando Ialenti, Suleman R Sabir, Iain B McInnes, James M Brewer, Paul Garside, Christian Weber, Thomas Lehmann, Daniel Teupser, Livia Habenicht, Michael Beer, Rolf Grabner, Pasquale Maffia, Falk Weih, Andreas J R Habenicht
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe(-/-) mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4(+) T cells, generated CD4(+), CD8(+), T regulatory (Treg) effector and central memory cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual set of dendritic cells and B cells...
June 16, 2015: Immunity
https://www.readbyqxmd.com/read/25993295/adventitial-tertiary-lymphoid-organs-as-potential-source-of-microrna-biomarkers-for-abdominal-aortic-aneurysm
#7
Rafaelle Spear, Ludovic Boytard, Renaud Blervaque, Maggy Chwastyniak, David Hot, Jonathan Vanhoutte, Bart Staels, Yves Lemoine, Nicolas Lamblin, François-René Pruvot, Stephan Haulon, Philippe Amouyel, Florence Pinet
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with marked changes in the cellular composition of the aortic wall. This study aims to identify microRNA (miRNA) expression in aneurysmal inflammatory cells isolated by laser microdissection from human tissue samples. The distribution of inflammatory cells (neutrophils, B and T lymphocytes, mast cells) was evaluated in human AAA biopsies. We observed in half of the samples that adventitial tertiary lymphoid organs (ATLOs) with a thickness from 0...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25152736/adventitial-inflammation-and-its-interaction-with-intimal-atherosclerotic-lesions
#8
REVIEW
Mohammadreza Akhavanpoor, Susanne Wangler, Christian A Gleissner, Grigorios Korosoglou, Hugo A Katus, Christian Erbel
The presence of adventitial inflammation in correlation with atherosclerotic lesions has been recognized for decades. In the last years, several studies have investigated the relevance and impact of adventitial inflammation on atherogenesis. In the abdominal aorta of elderly Apoe(-/-) mice, adventitial inflammatory structures were characterized as organized ectopic lymphoid tissue, and therefore termed adventitial tertiary lymphoid organs (ATLOs). These ATLOs possess similarities in development, structure and function to secondary lymphoid organs...
2014: Frontiers in Physiology
https://www.readbyqxmd.com/read/24587165/deciphering-the-stromal-and-hematopoietic-cell-network-of-the-adventitia-from-non-aneurysmal-and-aneurysmal-human-aorta
#9
Charles-Antoine Dutertre, Marc Clement, Marion Morvan, Knut Schäkel, Yves Castier, Jean-Marc Alsac, Jean-Baptiste Michel, Antonino Nicoletti
Aneurysm is associated to a complex remodeling of arteries that affects all their layers. Although events taking place in the intima and the media have received a particular attention, molecular and cellular events taking place in the adventitia have started to be deciphered only recently. In this study, we have precisely described the composition and distribution of stromal and hematopoietic cells in human arterial adventitia, both at steady state and in the setting of aortic aneurysm. Using polychromatic immunofluorescent and flow cytometry analyses, we observed that unlike the medial layer (which comprises mostly macrophages and T cells among leukocytes), the adventitia comprises a much greater variety of leukocytes...
2014: PloS One
https://www.readbyqxmd.com/read/23542081/adipose-specific-lipoprotein-lipase-deficiency-more-profoundly-affects-brown-than-white-fat-biology
#10
Itsaso Garcia-Arcos, Yaeko Hiyama, Konstantinos Drosatos, Kalyani G Bharadwaj, Yunying Hu, Ni Huiping Son, Sheila M O'Byrne, Chuchun L Chang, Richard J Deckelbaum, Manabu Takahashi, Marit Westerterp, Joseph C Obunike, Hongfeng Jiang, Hiroaki Yagyu, William S Blaner, Ira J Goldberg
Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acids via lipoprotein lipase (LpL). To determine how LpL affects the biology of adipose tissue, we created adipose-specific LpL knock-out (ATLO) mice, and we compared them with whole body LpL knock-out mice rescued with muscle LpL expression (MCK/L0) and wild type (WT) mice. ATLO LpL mRNA and activity were reduced, respectively, 75 and 70% in gonadal adipose tissue (GAT), 90 and 80% in subcutaneous tissue, and 84 and 85% in brown adipose tissue (BAT)...
May 17, 2013: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/22783198/control-of-dichotomic-innate-and-adaptive-immune-responses-by-artery-tertiary-lymphoid-organs-in-atherosclerosis
#11
Falk Weih, Rolf Gräbner, Desheng Hu, Michael Beer, Andreas J R Habenicht
Tertiary lymphoid organs (TLOs) emerge in tissues in response to non-resolving inflammation such as chronic infection, graft rejection, and autoimmune disease. We identified artery TLOs (ATLOs) in the adventitia adjacent to atherosclerotic plaques of aged hyperlipidemic ApoE(-/-) mice. ATLOs are structured into T cell areas harboring conventional dendritic cells and monocyte-derived DCs; B cell follicles containing follicular dendritic cells within activated germinal centers; and peripheral niches of plasma cells...
2012: Frontiers in Physiology
https://www.readbyqxmd.com/read/19436248/mandibular-condylar-fractures-and-acute-atlanto-axial-subluxation-part-1-a-new-clinical-and-nosographic-evidence
#12
COMPARATIVE STUDY
T Cutilli, A Corbacelli
AIM: The aim of this study was to analyze the acute repercussions of condylar mandibular fractures on occipital-atlanto-axial joint. METHODS: Twenty-five non-consecutive cases (16 males and 9 females, mean age: 22.96/range 14-36 years), observed and treated in the Maxillofacial Surgery Department of the University of L'Aquila have been considered. Types of fractures examined included: unilateral: 19 cases (solitary: 12; associated with other mandibular fractures: 7; homolateral: 2); bilateral: 6 cases (equivalent: 2; not equivalent: 4)...
May 2009: Minerva Stomatologica
https://www.readbyqxmd.com/read/19139167/lymphotoxin-beta-receptor-signaling-promotes-tertiary-lymphoid-organogenesis-in-the-aorta-adventitia-of-aged-apoe-mice
#13
Rolf Gräbner, Katharina Lötzer, Sandra Döpping, Markus Hildner, Dörte Radke, Michael Beer, Rainer Spanbroek, Beatrix Lippert, Catherine A Reardon, Godfrey S Getz, Yang-Xin Fu, Thomas Hehlgans, Reina E Mebius, Michael van der Wall, Dagmar Kruspe, Christoph Englert, Agnes Lovas, Desheng Hu, Gwendalyn J Randolph, Falk Weih, Andreas J R Habenicht
Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is increasingly recognized that this intimal inflammation is paralleled over time by a distinct inflammatory reaction in adjacent adventitia. Though cross talk between the coordinated inflammatory foci in the intima and the adventitia seems implicit, the mechanism(s) underlying their communication is unclear. Here, using detailed imaging analysis, microarray analyses, laser-capture microdissection, adoptive lymphocyte transfers, and functional blocking studies, we undertook to identify this mechanism...
January 16, 2009: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/17862488/v-atlo-axoid-fracture-dislocation
#14
L S Pilcher
No abstract text is available yet for this article.
February 1910: Annals of Surgery
https://www.readbyqxmd.com/read/17862147/iii-atlo-occipital-dislocation-a-case-of-fracture-of-the-atlas-and-axis-and-forward-dislocation-of-the-occiput-on-the-spinal-column-life-being-maintained-for-thirty-four-hours-and-forty-minutes-by-artificial-respiration-during-which-a-laminectomy-was-performed
#15
https://www.readbyqxmd.com/read/14864412/-neurologic-manifestations-connected-with-atlo-axoid-malformations
#16
R A SCHWOB, M BONDUELLE
No abstract text is available yet for this article.
July 4, 1951: La Presse Médicale
https://www.readbyqxmd.com/read/14394276/-chronic-and-delayed-cervical-myelopathy-compression-and-sclerosis-of-the-bone-marrow-following-undetected-atlo-axoid-fracture-dislocations
#17
J E PAILLAS, J LEGRE, J PELLEGRIN, J BONNAL
No abstract text is available yet for this article.
1955: Neuro-Chirurgie
https://www.readbyqxmd.com/read/14306080/-a-further-african-case-of-nontraumatic-atlo-axoid-dislocation
#18
A CARAYON, C GIORDANO, J L COURBIL, H COLLOMB
No abstract text is available yet for this article.
1965: Bulletin de la Société Médicale D'Afrique Noire de Langue Française
https://www.readbyqxmd.com/read/14281645/-late-myelopathies-due-to-atlo-epistrophic-dislocation-by-separation-of-the-odontoid-apophysis
#19
M GIAGHEDDU
No abstract text is available yet for this article.
1964: Rassegna di Studi Psichiatrici
https://www.readbyqxmd.com/read/13767249/-use-of-the-cranio-metro-localizing-method-of-l-martino-in-the-roentgen-stratigraphical-study-of-the-occipito-atlo-epistropheic-articulations-in-subjects-with-different-cranial-indexes-its-clinico-radiological-importance
#20
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