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https://www.readbyqxmd.com/read/28088609/leukemia-inhibitory-factor-impairs-structural-and-neurochemical-development-of-rat-visual-cortex-in-vivo
#1
Maren Engelhardt, Graziella di Cristo, Jochen Grabert, Silke Patz, Lamberto Maffei, Nicoletta Berardi, Petra Wahle
Minipump infusions into visual cortex in vivo at the onset of the critical period have revealed that the proinflammatory cytokine leukemia inhibitory factor (LIF) delays the maturation of thalamocortical projection neurons of the lateral geniculate nucleus, and tecto-thalamic projection neurons of the superior colliculus, and cortical layer IV spiny stellates and layer VI pyramidal neurons. Here, we report that P12-20 LIF infusion inhibits somatic maturation of pyramidal neurons and of all interneuron types in vivo...
January 11, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28077221/interpersonal-problems-predict-differential-response-to-cognitive-versus-behavioral-treatment-in-a-randomized-controlled-trial
#2
Michelle G Newman, Nicholas C Jacobson, Thane M Erickson, Aaron J Fisher
OBJECTIVE: We examined dimensional interpersonal problems as moderators of cognitive behavioral therapy (CBT) versus its components (cognitive therapy [CT] and behavioral therapy [BT]). We predicted that people with generalized anxiety disorder (GAD) whose interpersonal problems reflected more dominance and intrusiveness would respond best to a relaxation-based BT compared to CT or CBT, based on studies showing that people with personality features associated with a need for autonomy respond best to treatments that are more experiential, concrete, and self-directed compared to therapies involving abstract analysis of one's problems (e...
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28075650/pharmacokinetic-evaluation-of-pregabalin-for-the-treatment-of-generalized-anxiety-disorder
#3
Massimiliano Buoli, Alice Caldiroli, Marta Serati
Pregabalin is an alternative compound to SSRIs and SNRIs for the first-line treatment of generalized anxiety disorder (GAD). Areas covered: We describe the pharmacokinetic properties of pregabalin and their implications for the treatment of GAD. A search in the main database sources (Medline, ISI, Web of Knowledge and Medscape) was performed in order to obtain a comprehensive and balanced evaluation about the clinical implications of the pharmacokinetic properties of pregabalin in the treatment of GAD. The word "pregabalin" was associated with "pharmacokinetics", "interactions"', "GAD", "anxiety" and "tolerability"...
January 11, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28068460/side-effects-to-antidepressant-treatment-in-patients-with-depression-and-comorbid-panic-disorder
#4
Stewart A Shankman, Stephanie M Gorka, Andrea C Katz, Daniel N Klein, John C Markowitz, Bruce A Arnow, Rachel Manber, Barbara O Rothbaum, Michael E Thase, Alan F Schatzberg, Martin B Keller, Madhukar H Trivedi, James H Kocsis
OBJECTIVE: Side effects to antidepressant medication can affect the efficacy of treatment, but few predictors foretell who experiences side effects and which side effects they experience. This secondary data analysis examined whether depressed patients with comorbid panic disorder were more likely to experience side effects than those without panic disorder. The study also examined whether greater burden of side effects predicted a poorer treatment course for patients with panic disorder than those without panic disorder...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28062252/using-neuroimaging-to-individualize-tms-treatment-for-depression-toward-a-new-paradigm-for-imaging-guided-intervention
#5
Bruce M Luber, Simon Davis, Elisabeth Bernhardt, Andrada Neacsiu, Lori Kwapil, Sarah H Lisanby, Timothy J Strauman
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than state-of-the-science methods which incorporate fMRI-guided neuronavigation based on a specific model of neurocircuit dysfunction. In this review, we examine such a specific model drawn from regulatory focus theory, which postulates two brain/behavior systems, the promotion and prevention systems, underlying goal pursuit...
January 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28058109/engagement-and-outcomes-for-a-computerised-cognitive-behavioural-therapy-intervention-for-anxiety-and-depression-in-african-americans
#6
Charles R Jonassaint, Patrice Gibbs, Bea Herbeck Belnap, Jordan F Karp, Kaleab K Abebe, Bruce L Rollman
BACKGROUND: Computerised cognitive-behavioural therapy (CCBT) helps improve mental health outcomes in White populations. However, no studies have examined whether CCBT is acceptable and beneficial for African Americans. AIMS: We studied differences in CCBT use and self-reported change in depression and anxiety symptoms among 91 African Americans and 499 White primary care patients aged 18-75, enrolled in a randomised clinical trial of collaborative care embedded with an online treatment for depression and anxiety...
January 2017: BJPsych Open
https://www.readbyqxmd.com/read/28057609/intellicare-an-eclectic-skills-based-app-suite-for-the-treatment-of-depression-and-anxiety
#7
David C Mohr, Kathryn Noth Tomasino, Emily G Lattie, Hannah L Palac, Mary J Kwasny, Kenneth Weingardt, Chris J Karr, Susan M Kaiser, Rebecca C Rossom, Leland R Bardsley, Lauren Caccamo, Colleen Stiles-Shields, Stephen M Schueller
BACKGROUND: Digital mental health tools have tended to use psychoeducational strategies based on treatment orientations developed and validated outside of digital health. These features do not map well to the brief but frequent ways that people use mobile phones and mobile phone apps today. To address these challenges, we developed a suite of apps for depression and anxiety called IntelliCare, each developed with a focused goal and interactional style. IntelliCare apps prioritize interactive skills training over education and are designed for frequent but short interactions...
January 5, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28048325/th-cd-202-07-a-methodology-for-generating-numerical-phantoms-for-radiation-therapy-using-geometric-attribute-distribution-models
#8
S Dolly, H Chen, S Mutic, M Anastasio, H Li
PURPOSE: A persistent challenge for the quality assessment of radiation therapy treatments (e.g. contouring accuracy) is the absence of the known, ground truth for patient data. Moreover, assessment results are often patient-dependent. Computer simulation studies utilizing numerical phantoms can be performed for quality assessment with a known ground truth. However, previously reported numerical phantoms do not include the statistical properties of inter-patient variations, as their models are based on only one patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042613/targeting-cancer-using-polymeric-nanoparticle-mediated-combination-chemotherapy
#9
Aniket Gad, Janel Kydd, Brandon Piel, Prakash Rai
Cancer forms exhibiting poor prognosis have been extensively researched for therapeutic solutions. One of the conventional modes of treatment, chemotherapy shows inadequacy in its methodology due to imminent side-effects and acquired drug-resistance by cancer cells. However, advancements in nanotechnology have opened new frontiers to significantly alleviate collateral damage caused by current treatments via innovative delivery techniques, eliminating pitfalls encountered in conventional treatments. Properties like reduced drug-clearance and increased dose efficacy by the enhanced permeability and retention effect deem nanoparticles suitable for this application...
September 2016: Int J Nanomed Nanosurg
https://www.readbyqxmd.com/read/28032323/comorbidity-of-migraine-major-depressive-disorder-and-generalized-anxiety-disorder-in-adolescents-and-young-adults
#10
Lilian N Dindo, Ana Recober, Rita Haddad, Chadi A Calarge
PURPOSE: Depression and anxiety are highly comorbid psychiatric conditions and both are common in adult patients with migraine. This study aims to examine the unique associations between major depressive disorder (MDD) and generalized anxiety disorder (GAD) in a well-characterized group of older adolescents and college-age individuals with migraine. METHOD: Participants (N =  227), between 15 and 20 years old, who were unmedicated or within 1 month of beginning antidepressant treatment underwent a comprehensive psychiatric assessment to establish the presence of MDD and GAD, according to the Diagnostic and Statistical Manual, Fourth Edition, Text Revision, and to rate their symptom severity using the Longitudinal Interval Follow-up Evaluation for Adolescents (A-LIFE)...
December 28, 2016: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28025964/bioequivalence-of-two-formulations-of-pregabalin-150-mg-capsules-under-fasting-conditions-in-healthy-male-subjects%C3%A2
#11
Hyun Lee, SeungHwan Lee, Sung-Vin Yim, Bo-Hyung Kim
BACKGROUND: Pregabalin binds to the α2δ auxiliary subunit of voltage-gated calcium channels, which are widely distributed throughout the central and peripheral nervous systems and modulate calcium-dependent neurotransmitter release. Pregabalin is indicated for the treatment of peripheral and central neuropathic pain, partial seizures with or without secondary generalization, and treatment of generalized anxiety disorder (GAD). OBJECTIVE: The purpose of this study was to assess the bioequivalence of two different formulations of pregabalin 150-mg capsules in healthy Korean male subjects under fasting conditions...
December 27, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28025189/cardiopoietic-cell-therapy-for-advanced-ischemic-heart-failure-results-at-39-weeks-of-the-prospective-randomized-double-blind-sham-controlled-chart-1-clinical-trial
#12
Jozef Bartunek, Andre Terzic, Beth A Davison, Gerasimos S Filippatos, Slavica Radovanovic, Branko Beleslin, Bela Merkely, Piotr Musialek, Wojciech Wojakowski, Peter Andreka, Ivan G Horvath, Amos Katz, Dariouch Dolatabadi, Badih El Nakadi, Aleksandra Arandjelovic, Istvan Edes, Petar M Seferovic, Slobodan Obradovic, Marc Vanderheyden, Nikola Jagic, Ivo Petrov, Shaul Atar, Majdi Halabi, Valeri L Gelev, Michael K Shochat, Jaroslaw D Kasprzak, Ricardo Sanz-Ruiz, Guy R Heyndrickx, Noémi Nyolczas, Victor Legrand, Antoine Guédès, Alex Heyse, Tiziano Moccetti, Francisco Fernandez-Aviles, Pilar Jimenez-Quevedo, Antoni Bayes-Genis, Jose Maria Hernandez-Garcia, Flavio Ribichini, Marcin Gruchala, Scott A Waldman, John R Teerlink, Bernard J Gersh, Thomas J Povsic, Timothy D Henry, Marco Metra, Roger J Hajjar, Michal Tendera, Atta Behfar, Bertrand Alexandre, Aymeric Seron, Wendy Gattis Stough, Warren Sherman, Gad Cotter, William Wijns
AIMS: Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. METHODS AND RESULTS: This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion...
December 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28019122/sedative-hypnotic-use-among-older-adults-participating-in-anxiety-research
#13
Elizabeth C Conti, Melinda A Stanley, Amber B Amspoker, Mark E Kunik
Older adults are prescribed sedative-hypnotic medications at higher rates than younger adults. These are not recommended for older adults due to risk of sedation, cognitive impairment, and falls. Severe generalized anxiety disorder (GAD) is a possibly appropriate use of these medications in older people, but little is available on use of sedative-hypnotic medications among older adults with GAD. This study examined the frequency and predictors of sedative-hypnotic medication use among older adults screening positive for anxiety...
January 1, 2016: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28006984/illness-perception-patterns-in-patients-with-coronary-artery-disease
#14
E Kunschitz, O Friedrich, Ch Schöppl, J Maitz, J Sipötz
The purpose of this study is to identify patterns of illness perception in patients with angiografically verified Coronary Artery Disease. A total of 166 patients (age: 64.4 ± 12.1, 80.7% male) were recruited after angiography. Cluster analysis on the items of the Brief Illness Perception Questionnaire was used to identify patterns of illness perception. The resulting groups were characterized with regard to Quality of Life (MacNew), anxiety and depression (GAD-7 and PHQ-9) and resilience (RS-13). The analysis revealed 4 distinct groups differing with regard to the items covering the perception of the physical and emotional impact of disease...
December 23, 2016: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27994467/diminished-autonomic-neurocardiac-function-in-patients-with-generalized-anxiety-disorder
#15
Kyungwook Kim, Seul Lee, Jong-Hoon Kim
BACKGROUND: Generalized anxiety disorder (GAD) is a chronic and highly prevalent disorder that is characterized by a number of autonomic nervous system symptoms. The purpose of this study was to investigate the linear and nonlinear complexity measures of heart rate variability (HRV), measuring autonomic regulation, and to evaluate the relationship between HRV parameters and the severity of anxiety, in medication-free patients with GAD. METHODS: Assessments of linear and nonlinear complexity measures of HRV were performed in 42 medication-free patients with GAD and 50 healthy control subjects...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27992493/clinical-and-metabolic-characteristics-among-mexican-children-with-different-types-of-diabetes-mellitus
#16
María Lola Evia-Viscarra, Rodolfo Guardado-Mendoza, Edel Rafael Rodea-Montero
BACKGROUND: Current classification of diabetes mellitus (DM) is based on etiology and includes type 1 (T1DM), type 2 (T2DM), gestational, and other. Clinical and pathophysiological characteristics of T1DM and T2DM in the same patient have been designated as type 1.5 DM (T1.5DM). OBJECTIVES: The aim of this study was to classify pediatric patients with DM based on pancreatic autoimmunity and the presence or absence of overweight/obesity, and to compare the clinical, anthropometric, and biochemical characteristics between children in the different classes of DM...
2016: PloS One
https://www.readbyqxmd.com/read/27982510/stress-system-dysregulation-in-pediatric-generalized-anxiety-disorder-associated-with-comorbid-depression
#17
R Funke, A Eichler, J Distler, Y Golub, O Kratz, G H Moll
Because chronic stress is an important risk factor for anxiety states and depressive disorders, we studied hypothalamus-pituitary-adrenal (HPA) axis and sympathetic system activity via changes in cortisol and alpha amylase activity levels in pediatric generalized anxiety disorder (GAD) patients (n = 26) with comorbid depression and a healthy comparison group (n = 26). Morning plasma cortisol and diurnal profiles of salivary cortisol and salivary alpha amylase (sAA) activity were assessed, also reactivity of HPA-axis, sAA activity, and heart rate following a psychosocial stressor (Trier Social Stress Test for children)...
December 16, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/27979827/protective-roles-of-hepatic-gaba-signaling-in-acute-liver-injury-of-rats
#18
Shuanglian Wang, Yun-Yan Xiang, Jianchun Zhu, Fan Yi, Jingxin Li, Chuanyong Liu, Wei-Yang Lu
Gamma-aminobutyric acid (GABA) is produced by various cells through the catalytic activity of glutamic acid decarboxylase (GAD). Activation of type-A GABA receptor (GABAAR) inhibits stem cell proliferation but protects differentiated cells from injures. The present study investigated hepatic GABA signaling system and the role of this system in liver physiology and pathophysiology. RT-PCR and immunoblot assays identified GAD and GABAAR subunits in rat livers and in HepG2 and Clone 9 hepatocytes. Patch-clamp recording detected GABA-induced currents in Clone 9 hepatocytes and depolarization in WITT cholangiocytes...
December 15, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27977290/implementation-of-an-acceptance-and-mindfulness-based-group-for-depression-and-anxiety-in-primary-care-initial-outcomes
#19
Cara H Fuchs, Natasha Haradhvala, Daniel R Evans, Justin M Nash, Risa B Weisberg, Lisa A Uebelacker
INTRODUCTION: Depression and anxiety disorders are highly prevalent among primary care patients. Group visits provide a way of delivering interventions to multiple patients at the same time. Group visits for depression and anxiety present an opportunity to expand the reach of behavioral health services for primary care patients. The goal of the current study was to evaluate the implementation of an acceptance and mindfulness-based group for primary care patients with depression and anxiety...
December 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27969075/prevalence-correlates-comorbidity-and-severity-of-generalized-anxiety-disorder-in-singapore
#20
Siau Pheng Lee, Vathsala Sagayadevan, Edimansyah Abdin, Janhavi Ajit Vaingankar, Siow Ann Chong, Mythily Subramaniam
Despite its pervasiveness and associated impairment, generalized anxiety disorder (GAD) remains a poorly recognized disorder. Furthermore, given that GAD has been relatively understudied in Asia, the current study examined the prevalence, correlates and co-morbid conditions of this disorder in a multi-ethnic population of Singapore. Data was utilized from the Singapore Mental Health Study (SMHS), a cross-sectional epidemiological survey conducted among the adult population (n=6616) aged 18 years and above. The Composite International Diagnostic Interview version 3...
October 2016: Asian Journal of Psychiatry
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