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https://www.readbyqxmd.com/read/28319423/silexan-does-not-cause-withdrawal-symptoms-even-when-abruptly-discontinued
#1
M Gastpar, W E Müller, H P Volz, H J Möller, S Schläfke, A Dienel, S Kasper
OBJECTIVE: Subsequent to a randomised, double-blind, double dummy clinical trial assessing the efficacy of silexan compared to placebo and paroxetine in patients suffering from generalised anxiety disorder (GAD), a 1week follow-up phase was added in order to assess possible withdrawal symptoms of silexan after abrupt discontinuation. METHODS: Participants received silexan 80 mg/d, silexan 160 mg/d, paroxetine 20 mg/d, or placebo at a ratio of 1:1:1:1. Study medication was discontinued after the 10 week active treatment phase of the original trial...
March 20, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28314552/effects-of-mindfulness-meditation-on-occupational-functioning-and-health-care-utilization-in-individuals-with-anxiety
#2
Elizabeth A Hoge, Brittany M Guidos, Mihriye Mete, Eric Bui, Mark H Pollack, Naomi M Simon, Mary Ann Dutton
OBJECTIVES: To examine the effect of mindfulness meditation on occupational functioning in individuals with Generalized anxiety disorder (GAD). METHODS: Fifty-seven individuals with GAD (mean (SD) age=39 (13); 56% women) participated in an 8-week clinical trial in which they were randomized to mindfulness-based stress reduction (MBSR) or an attention control class. In this secondary analysis, absenteeism, entire workdays missed, partial workdays missed, and healthcare utilization patterns were assessed before and after treatment...
April 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28303465/pharmacotherapy-in-generalized-anxiety-disorder-novel-experimental-medicine-models-and-emerging-drug-targets
#3
REVIEW
David S Baldwin, Ruihua Hou, Robert Gordon, Nathan T M Huneke, Matthew Garner
Many pharmacological and psychological approaches have been found efficacious in patients with generalized anxiety disorder (GAD), but many treatment-seeking patients will not respond and others will relapse despite continuing with interventions that initially had beneficial effects. Other patients will respond but then stop treatment early because of untoward effects such as sexual dysfunction, drowsiness, and weight gain. There is much scope for the development of novel approaches that could have greater overall effectiveness or acceptability than currently available interventions or that have particular effectiveness in specific clinical subgroups...
March 16, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28299303/the-efficacy-of-augment-of-d-cycloserine-and-cognitive-behavioral-therapy-on-adolescent-with-one-type-of-anxiety-disorders-a-double-blind-randomized-controlled-trial
#4
Soroor Arman, Ali Soheilimehr, Mohammad Reza Maracy
BACKGROUND: This study was designed to investigating the effect of combining D-cycloserine (DCS) and cognitive-behavioral therapy (CBT) on adolescent with at least one type of anxiety disorders. MATERIALS AND METHODS: The present study was conducted as a double-blind randomized controlled trial on 36 adolescent with anxiety disorders. Patients were assessed in two groups. In addition to 4 sessions of weekly CBT in both groups; case group, received a 50-mg DCS capsules, control group, received Placebo daily for a month...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28298261/efficacy-and-safety-of-agomelatine-10-or-25-mg-day-in-non-depressed-out-patients-with-generalized-anxiety-disorder-a-12-week-double-blind-placebo-controlled-study
#5
Dan J Stein, Antti Ahokas, Marek Jarema, Alla S Avedisova, Livia Vavrusova, Oleg Chaban, Céline Gruget, Valérie Olivier, Françoise Picarel-Blanchot, Christian de Bodinat
Agomelatine is efficacious in reducing symptoms and preventing relapse in placebo-controlled trials in generalised anxiety disorder (GAD). Nevertheless, fixed dose studies of agomelatine in GAD have not been undertaken. To determine the minimally effective optimal dose of agomelatine in GAD, the efficacy of two doses of agomelatine (10 and 25mg/day) was investigated in a 12-week, placebo-controlled, double-blind, international study in patients with a primary diagnosis of GAD. The primary outcome measure was the Hamilton Anxiety scale (HAM-A)...
March 12, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28297020/cross-sectional-comparison-of-the-epidemiology-of-dsm-5-generalized-anxiety-disorder-across-the-globe
#6
Ayelet Meron Ruscio, Lauren S Hallion, Carmen C W Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Jordi Alonso, Laura Helena Andrade, Guilherme Borges, Evelyn J Bromet, Brendan Bunting, José Miguel Caldas de Almeida, Koen Demyttenaere, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Josep Maria Haro, Yanling He, Hristo Hinkov, Chiyi Hu, Peter de Jonge, Elie G Karam, Sing Lee, Jean-Pierre Lepine, Daphna Levinson, Zeina Mneimneh, Fernando Navarro-Mateu, José Posada-Villa, Tim Slade, Dan J Stein, Yolanda Torres, Hidenori Uda, Bogdan Wojtyniak, Ronald C Kessler, Somnath Chatterji, Kate M Scott
Importance: Generalized anxiety disorder (GAD) is poorly understood compared with other anxiety disorders, and debates persist about the seriousness of this disorder. Few data exist on GAD outside a small number of affluent, industrialized nations. No population-based data exist on GAD as it is currently defined in DSM-5. Objective: To provide the first epidemiologic data on DSM-5 GAD and explore cross-national differences in its prevalence, course, correlates, and impact...
March 15, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28292203/simple-screening-for-neurocognitive-impairment-in-routine-hiv-outpatient-care-is-it-deliverable
#7
Sarah Parry, Sarah Zetler, Anna Kentridge, Jenny Petrak, Tristan Barber
Routine screening for psychological and cognitive difficulties is recommended in BHIVA guidelines but screening questions are not specified and studies give varied recommendations. Our aim was to see if simple screening in the routine clinic could help better direct our referrals to psychology and highlight those patients requiring, and likely to benefit from, further assessment. We introduced brief questions to assess neurocognitive impairment (NCI) and mood into routine HIV visits, with an onward referral pathway for further investigation for those screening positive...
March 14, 2017: AIDS Care
https://www.readbyqxmd.com/read/28285601/canine-leishmaniosis-caused-by-leishmania-major-and-leishmania-tropica-comparative-findings-and-serology
#8
Gad Baneth, Daniel Yasur-Landau, Matan Gilad, Yaarit Nachum-Biala
BACKGROUND: Infection and clinical disease associated with Leishmania major and Leishmania tropica, two common agents of human cutaneous leishmaniosis, have rarely been reported in dogs. This study describes dogs infected with these Leishmania spp. prevalent in the Middle East and North Africa, and compares the serological response of dogs infected with Leishmania infantum, L. major or L. tropica to whole promastigote antigen enzyme-linked immunosorbent assay (ELISA) of each species and to rK39 dipstick...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28285590/molecular-detection-of-hepatozoon-spp-and-cytauxzoon-sp-in-domestic-and-stray-cats-from-madrid-spain
#9
David Díaz-Regañón, Alejandra Villaescusa, Tania Ayllón, Fernando Rodríguez-Franco, Gad Baneth, Lydia Calleja-Bueno, Mercedes García-Sancho, Beatriz Agulla, Ángel Sainz
BACKGROUND: Different species of apicomplexan protozoans of the genera Hepatozoon and Cytauxzoon can infect domestic cats, but their epidemiology and clinical relevance are not fully understood. The aim of this study was to assess the molecular prevalence of Hepatozoon spp. and Cytauxzoon spp. and to identify associated risk factors and clinical and laboratory abnormalities in a population of cats from Madrid, Spain. METHODS: Six hundred and forty-four client-owned and stray cats from Madrid, Spain, were included in this study...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28284107/clinical-characteristics-and-treatment-outcomes-of-patients-with-major-depressive-disorder-and-comorbid-anxiety-disorders-results-from-a-european-multicenter-study
#10
Markus Dold, Lucie Bartova, Daniel Souery, Julien Mendlewicz, Alessandro Serretti, Stefano Porcelli, Joseph Zohar, Stuart Montgomery, Siegfried Kasper
This naturalistic European multicenter study aimed to elucidate the association between major depressive disorder (MDD) and comorbid anxiety disorders. Demographic and clinical information of 1346 MDD patients were compared between those with and without concurrent anxiety disorders. The association between explanatory variables and the presence of comorbid anxiety disorders was examined using binary logistic regression analyses. 286 (21.2%) of the participants exhibited comorbid anxiety disorders, 10.8% generalized anxiety disorder (GAD), 8...
February 27, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28281938/joint-trajectories-of-cigarette-smoking-and-depressive-symptoms-from-the-mid-twenties-to-the-mid-thirties-predicting-generalized-anxiety-disorder
#11
Jung Yeon Lee, Judith S Brook, Stephen J Finch, Mario De La Rosa, David W Brook
The current study examines the longitudinal patterns of both cigarette smoking and depressive symptoms as predictors of generalized anxiety disorder (GAD) using data from the Harlem Longitudinal Development Study. There were 674 African American (53%) and Puerto Rican (47%) participants. Among the 674 participants, 60% were females. In the logistic regression analyses, the indicator variables of membership in each of the joint trajectories of cigarette smoking and depressive symptoms from the mid 20s to the mid 30s were used as the independent variables, and the diagnosis of GAD in the mid 30s was used as the dependent variable...
March 10, 2017: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/28280900/paracrine-gaba-and-insulin-regulate-pancreatic-alpha-cell-proliferation-in-a-mouse-model-of-type-1-diabetes
#12
Allen L Feng, Yun-Yan Xiang, Le Gui, Gesthika Kaltsidis, Qingping Feng, Wei-Yang Lu
AIMS/HYPOTHESIS: This study aimed to elucidate the mechanism of increased proliferation of alpha cells in recent-onset type 1 diabetes. Pancreatic beta cells express GAD and produce γ-aminobutyric acid (GABA), which inhibits alpha cell secretion of glucagon. We explored the roles of GABA in alpha cell proliferation in conditions corresponding to type 1 diabetes in a mouse model and in vitro. METHODS: Type 1 diabetes was induced by injecting the mice with streptozotocin (STZ)...
March 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/28277857/usefulness-of-self-report-questionnaires-for-psychological-assessment-of-patients-with-tinnitus-and-hyperacusis-and-patients-views-of-the-questionnaires
#13
Hashir Aazh, Brian C J Moore
OBJECTIVE: The objective was to determine the relevance and applicability of psychological questionnaires to patients seeking help for tinnitus and/or hyperacusis. DESIGN: This was a questionnaire-based survey. The following questionnaires were administered: Generalised Anxiety Disorder (GAD-7), Short Health Anxiety Inventory (SHAI), Mini-Social Phobia Inventory (Mini-SPIN), Obsessive Compulsive Inventory-Revised (OCI-R), Panic Disorder Severity Scale-Self Report (PDSS-SR), Patient Health Questionnaire (PHQ-9) and Penn State Worry Questionnaire-Abbreviated version (PSWQ-A)...
March 9, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28273586/alterations-of-circulating-nucb2-nesfatin-1-during-short-term-therapeutic-improvement-of-anxiety-in-obese-inpatients
#14
Tobias Hofmann, Elena Weibert, Anne Ahnis, Alexander Obbarius, Ulf Elbelt, Matthias Rose, Burghard F Klapp, Andreas Stengel
In addition to its anorexigenic properties in the neuroendocrine regulation of hunger and satiety, mounting evidence indicates a role for NUCB2/nesfatin-1 in the regulation of emotional stress responses which seems to occur in a sex-specific way. In the present study, we investigated the association of NUCB2/nesfatin-1 plasma levels with anxiety, depressiveness and perceived stress in obese men and women and their alterations during inpatient treatment. We expected a decrease of NUCB2/nesfatin-1 levels in female and an increase in male patients reporting a relevant alleviation of anxiety...
February 21, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28272131/predictors-of-pharmacotherapy-response-in-generalized-anxiety-disorder-a-systematic-review
#15
Rafael Ferreira-Garcia, Marina Mochcovitch, Mariana Costa do Cabo, Antonio Egídio Nardi, Rafael Christophe Freire
BACKGROUND: Pharmacotherapy for generalized anxiety disorder (GAD) may be effective in reducing symptoms in the majority of patients. The study of moderators and predictors of treatment response may help clinicians both to select appropriate interventions to maximize the probability of response and to inform the general prognosis. METHODS: A systematic literature search of electronic databases, selected authors, and reference lists was used to identify articles that reported trials of drug monotherapy in GAD...
March 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28262911/echocardiographic-predictors-of-outcome-in-acute-heart-failure-patients-in-sub-saharan-africa-insights-from-thesus-hf
#16
MULTICENTER STUDY
Mahmoud U Sani, Beth A Davison, Gad Cotter, Albertino Damasceno, Bongani M Mayosi, Okechukwu S Ogah, Charles Mondo, Anastase Dzudie, Dike B Ojji, Charles Kouam Kouam, Ahmed Suliman, Gerald Yonga, Sergine Abdou Ba, Fikru Maru, Bekele Alemayehu, Christopher Edwards, Karen Sliwa
BACKGROUND: The role of echocardiography in the risk stratification of acute heart failure (HF) is unknown. Some small studies and retrospective analyses have found little change in echocardiographic variables during admission for acute HF and some echocardiographic parameters were not found to be associated with outcomes. It is unknown which echocardiographic variables will predict outcomes in sub-Saharan African patients admitted with acute HF. Using echocardiograms, this study aimed to determine the predictors of death and re-admissions within 60 days and deaths up to 180 days in patients with acute heart failure...
January 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28260554/social-anxiety-and-fear-of-causing-discomfort-to-others-diagnostic-specificity-symptom-correlates-and-cbt-treatment-outcome
#17
Yasunori Nishikawa, Judith M Laposa, Rotem Regev, Neil A Rector
BACKGROUND: Patients with social anxiety disorder (SAD) report fear content relating to the perceived aversive consequences of their anxiety for others in their social environment. However, no studies to date have examined the diagnostic specificity of these fears to SAD as well as predictors to treatment response of these fears. AIMS: To examine relative specificity of fears related to causing discomfort to others, as measured by Social Anxiety-Fear of Causing Discomfort to Others (SA-DOS), among patients with anxiety disorders, obsessive compulsive disorder (OCD) and major depressive disorder (MDD), in addition to relation between dysfunctional attitudes and treatment response among patients with SAD...
March 6, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28259062/the-association-between-parents-ratings-of-asd-symptoms-and-anxiety-in-a-sample-of-high-functioning-boys-and-adolescents-with-autism-spectrum-disorder
#18
Vicki Bitsika, Christopher F Sharpley
BACKGROUND: The relationship between symptoms of Autism Spectrum Disorder (ASD) and Generalised Anxiety Disorder (GAD) is complex and sometimes confounding. However, exploration of that relationship has significant potential to assist in treatment or avoidance of GAD by identifying ASD-related behaviours as 'targets' for intervention with anxious children as well as for preventative treatments that could be implemented into daily routines before children become anxious. To further understanding of this relationship, the association between parent-ratings of their sons' ASD symptoms and GAD symptoms was investigated in two samples of boys with high-functioning ASD...
March 1, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28259052/gold-modified-indium-tin-oxide-as-a-transparent-window-in-optoelectronic-diagnostics-of-electrochemically-active-biofilms
#19
Igor Schmidt, Alaaeldin Gad, Gregor Scholz, Heidi Boht, Michael Martens, Meinhard Schilling, Hutomo Suryo Wasisto, Andreas Waag, Uwe Schröder
Microbial electrochemical technologies (METs) are one of the emerging green bioenergy domains that are utilizing microorganisms for wastewater treatment or electrosynthesis. Real-time monitoring of bioprocess during operation is a prerequisite for understanding and further improving bioenergy harvesting. Optical methods are powerful tools for this, but require transparent, highly conductive and biocompatible electrodes. Whereas indium tin oxide (ITO) is a well-known transparent conductive oxide, it is a non-ideal platform for biofilm growth...
February 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28251612/diagnosis-of-deep-pelvic-masses-on-a-gynaecology-service-trans-vaginal-ultrasound-guided-needle-aspiration-of-pelvic-solid-and-cystic-lesions
#20
Ram Eitan, Yoav Peled, Gad Sabah, Haim Krissi, Avi Ben Haroush, Israel Meizner, David Danon, Ron Bardin, Ariella Jakobson-Setton, Liat Salzer, Reuven Mashiach
OBJECTIVES: Women with undiagnosed pelvic lesions are often referred for evaluation and treatment. Transvaginal ultrasound-guided fine needle aspiration (TVUS-FNA) biopsy can assist in making management decisions. We describe our experience with this modality. METHODS: We performed a retrospective chart review of all women who had a TVUS-FNA biopsy between January 2004 and December 2014. Charts were reviewed for clinicopathologic information. The pathologic results of the TVUS-FNA were compared with the final diagnosis...
March 2, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
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