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Cervical intraepithelial lesions

Lili Yao, Min Yuan, Jianlin Yuan, Ping Zhou, Lipa Mei, Jingxin Cheng
This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, and cervical biopsy were used to screen CC.In 2300 cases, HPV was detected in 385 cases with infection rate of 16.74%. The infection rates of Uygur and Han women were 20.08% and 13.39%, respectively, with significant differences (P <...
November 2018: Medicine (Baltimore)
Filipa Godoy-Vitorino, Josefina Romaguera, Chunyu Zhao, Daniela Vargas-Robles, Gilmary Ortiz-Morales, Frances Vázquez-Sánchez, Maria Sanchez-Vázquez, Manuel de la Garza-Casillas, Magaly Martinez-Ferrer, James Robert White, Kyle Bittinger, Maria Gloria Dominguez-Bello, Martin J Blaser
The human cervicovaginal microbiota resides at an interface between the host and the environment and may affect susceptibility to disease. Puerto Rican women have high human papillomavirus (HPV) infection and cervical cancer rates. We hypothesized that the population structure of the cervicovaginal bacterial and fungal biota changed with cervical squamous intraepithelial lesions and HPV infections. DNA was extracted from cervix, introitus, and anal sites of 62 patients attending high-risk San Juan clinics. The 16S rRNA V4 region and ITS-2 fungal regions were amplified and sequenced using Illumina technology...
2018: Frontiers in Microbiology
Anna Hester, Manuel Ritzer, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Thomas Kolben, Christian Dannecker, Sven Mahner, Udo Jeschke, Theresa Maria Kolben
PURPOSE: Prostaglandin-mediated inflammatory reactions play a major role in different cancers. Prostaglandin E2-receptor 3 (EP3) expression correlates with FIGO stages in cervical cancer and has been shown to be an independent prognostic factor for overall survival. EP3 expression levels in cervical intraepithelial neoplasia (CIN) as the precursor lesion of cervical cancer are currently unknown. METHODS: EP3 expression was analyzed by immunohistochemistry in 124 patient samples (CIN 1-3 and healthy controls) using the IR-scoring system...
November 7, 2018: Journal of Cancer Research and Clinical Oncology
Lin Tao, A Amanguli, Feng Li, Ying Hong Wang, Lan Yang, Meiliguli Mohemaiti, Jin Zhao, Xiao Guang Zou, Abudukeyoumu Saimaiti, Mirensha Abudu, Mikairemu Maimaiti, Shi Yan Chen, Ruxianguli Abudukelimu, Ayinuer Maimaiti, Shu Gang Li, Wei Zhang, Ayinuer Aizimu, An Qiang Yang, Ju Wang, Li Juan Pang, Yu Guang Cao, Wen Yi Gu, Wen Jie Zhang
OBJECTIVE: To develop an effective, low-cost, single-visit cervical screening strategy incorporating a modified Pap test and visual inspection with acetic acid and Lugol's iodine for low-income settings. METHODS: We conducted a prospective cohort trial. Two low-income Muslim Uyghur communities in China's far western Kashi Prefecture served as pilot and validation study sites, respectively, and 4,049 women (aged 30-59 years) were screened. The conventional Pap test was modified using a cotton swab to collect cervical cells without scraping the cervix using an Ayre spatula, allowing visual inspection with acetic acid (and visual inspection with Lugol's iodine if visual inspection with acetic acid was negative) to be performed in a single visit...
November 5, 2018: Obstetrics and Gynecology
Andrea C Des Marais, Yuqian Zhao, Marcia M Hobbs, Vijay Sivaraman, Lynn Barclay, Noel T Brewer, Jennifer S Smith
OBJECTIVE: To evaluate the validity and acceptability of at-home self-collection to test for high-risk human papillomavirus (HPV) and sexually transmitted infections among women overdue for cervical cancer screening by national guidelines. METHODS: Low-income, infrequently screened women were recruited from the general population in North Carolina to participate in an observational study. Participants provided two self-collected cervicovaginal samples (one at home and one in the clinic) and a clinician-collected cervical sample...
November 5, 2018: Obstetrics and Gynecology
Kurt G Davis, Guy R Orangio
Despite the progress made in the reduction of squamous cell carcinoma of the cervix, the incidence of anal squamous cell carcinoma (ASCC) has been increasing since 1992. While it remains an uncommon disease, the prevalence is climbing steadily. Among human immunodeficiency virus (HIV)-infected adults, especially men who have sex with men, ASCC is one of the more common non-AIDS-defining malignancies. The precursor lesion, anal intraepithelial neoplasia (AIN), is prevalent in the HIV-infected population. More than 90% of ASCCs are related to human papilloma virus (HPV), oncogenic types (HPV 16, 18)...
November 2018: Clinics in Colon and Rectal Surgery
Pamela J Toliman, John M Kaldor, Steven G Badman, Josephine Gabuzzi, Selina Silim, Antonia Kumbia, Benny Kombuk, Zure Kombati, Gloria Munnull, Rebecca Guy, Lisa M Vallely, Angela Kelly-Hanku, Handan Wand, Claire Ryan, Grace Tan, Julia Brotherton, Marion Saville, Glen D L Mola, Suzanne M Garland, Sepehr N Tabrizi, Andrew J Vallely
The performance of different clinical screening algorithms comprising point-of-care HPV-DNA testing using self-collected vaginal ('V') specimens, and visual inspection of the cervix with acetic acid (VIA) was evaluated in Papua New Guinea. Women aged 30-59 years provided V specimens that were tested at point-of-care using the Xpert HPV Test (Cepheid, Sunnyvale, CA). A clinician-collected cervical ('C') specimen was then collected for point-of-care Xpert testing, and liquid-based cytology (LBC). Following this, VIA examination was conducted, blind to HPV test results, and ablative cervical cryotherapy provided if indicated...
October 31, 2018: Papillomavirus Research
Carrie R Innes, Peter H Sykes, Dianne Harker, Jonathan A Williman, Rachael A Van der Griend, Martin Whitehead, Merilyn Hibma, Beverley A Lawton, Peter Fitzgerald, Narena M Dudley, Simone Petrich, Jim Faherty, Cecile Bergzoll, Lois Eva, Lynn Sadler, Bryony J Simcock
In 2008, a quadrivalent human papillomavirus (HPV) vaccine (genotypes 6, 11, 16, 18) became available in New Zealand. This study investigated whether the proportion of cervical intraepithelial neoplasia grade 2 (CIN2) lesions associated with HPV genotypes 16 and 18 changed over time in young women recruited to a prospective CIN2 observational management trial (PRINCess) between 2013-2016. Partial HPV genotyping (16, 18, or other high risk HPV) was undertaken on n=392 women under 25 years (mean age 21.8, range 17-24) with biopsy-diagnosed CIN2...
October 31, 2018: Papillomavirus Research
Linhong Liao, Hui Cheng, Fansheng Zeng, Weijie Zhou, Yanqing Ding
BACKGROUND: Human papillomavirus (HPV) infection can lead to the development of cervical cancer. This study assessed the genotype distribution of HPV of high-grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer (ICC) in Ganzhou population. METHODS: A total of 935 females who got HPV testing from January 2016 to July 2018 in the maternal and child health hospital of Ganzhou were enrolled in the study, including 806 HSIL and 129 ICC. HPV detection and genotyping were tested by HPV Geno-Array test kit...
November 2, 2018: Journal of Clinical Laboratory Analysis
Masayuki Shintaku, Hiromi Taniguchi, Yoshihiro Yamamoto, Fumihiko Kono, Masahiro Sumitomo
Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-year-old woman, in whom cervical smears contained adenocarcinoma cells, but cervical conization did not reveal adenocarcinoma. Because the post-conization smears again demonstrated adenocarcinoma cells, hysterectomy with bilateral salpingectomy was performed 16 months after the first detection of adenocarcinoma cells in cervical smears...
October 30, 2018: Diagnostic Cytopathology
Fabio Bottari, Anna Daniela Iacobone, Sara Boveri, Eleonora Petra Preti, Dorella Franchi, Luciano Mariani, Mario Preti, Fabio Landoni, Rita Passerini, Maria Teresa Sandri
OBJECTIVE: Many methods are available today for human papillomavirus (HPV) testing; they differ for technology, targets, and information on the genotypes detected. In this study, we evaluated the performance of the Onclarity HPV assay in detection and follow-up of cervical preneoplastic lesions. MATERIALS AND METHODS: One hundred sixty-seven women referred to the European Institute of Oncology, Milan, for treatment of cervical lesions were enrolled. We investigated the utility of Onclarity extended genotyping HPV test in the management of cervical intraepithelial neoplasia (CIN) 2+ preneoplastic lesion...
October 26, 2018: Journal of Lower Genital Tract Disease
Limei Chen, Li Liu, Xiang Tao, Luopei Guo, Hongwei Zhang, Long Sui
OBJECTIVE: The aim of the study was to analyze the clinical outcomes of high-grade squamous intraepithelial lesion (HSIL) 6 months after loop electrosurgical excision procedure (LEEP). We explored the risk factors of persistent cervical HSIL after LEEP and evaluated the methods of follow-up. PATIENTS AND METHODS: This retrospective study included women who underwent a LEEP and had a diagnosis of HSIL in their LEEP specimen during 2011 to 2015. The purpose was to determine the risk factors among these women for having persistent HSIL disease at their 6-month follow-up visit...
October 26, 2018: Journal of Lower Genital Tract Disease
X Zhang, X J Guan, J Q Li, L H Zhang, J H Yang
Objective: To investigate the pathological escalation after cervical cone resection in postmenopausal women, and analyze the related influencing factors. Methods: A retrospective cohort study was conducted at the Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University between July 2013 and January 2015. Seven hundred and fifty cases of cervical cone-cut were enrolled in this study, 129 cases of them were postmenopausal women, and 621 were premenopausal women. All results of patients' liquid-based thin-layer cytology (TCT) , HPV test, colposcopy and biopsy pathology, cervical cone resection and postoperative pathological examination were collected...
October 25, 2018: Zhonghua Fu Chan Ke za Zhi
Oscar G W Wong, Obe K L Tsun, Eva Y Tsui, Joanne N K Chow, Philip P C Ip, Annie N Y Cheung
BACKGROUND: High-risk human papillomavirus (hrHPV) detection and genotyping by Cobas HPV test has become an important technical platform in cervical cancer screening. It may be used as a co-test with cervical cytology or as a standalone test. Aptima HPV assay (AHPV) is another hrHPV test detecting 13 genotypes through qPCR based amplification of viral E6/E7 transcripts. Partial genotyping with Aptima HPV 16 18/45 genotype assay (AHPV GT) on positive samples is possible. Evidence supporting the performance of AHPV in Asian populations is scarce...
October 13, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Frederik A Stuebs, Carla E Schulmeyer, Grit Mehlhorn, Paul Gass, Sven Kehl, Simone K Renner, Stefan P Renner, Carol Geppert, Werner Adler, Arndt Hartmann, Matthias W Beckmann, Martin C Koch
PURPOSE: Colposcopy-directed biopsy is a cornerstone method for diagnosing cervical intraepithelial neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with definitive surgery. METHODS: The accuracy of colposcopy-directed biopsy was compared with the final histology in relation to different types of transformation zone (TZ), the patient's age, and the examiner's level of training. RESULTS: The overall accuracy of biopsy in comparison with definitive surgery was 71...
October 27, 2018: Archives of Gynecology and Obstetrics
Emmanouil Papasavvas, Andrew V Kossenkov, Livio Azzoni, Nicola M Zetola, Agnieszka Mackiewicz, Brian N Ross, Matthew Fair, Surya Vadrevu, Doreen Ramogola-Masire, Ian Sanne, Cynthia Firnhaber, Luis J Montaner
Identification of factors associated with human papillomavirus (HPV) cervical histopathology or recurrence/relapse following loop electrosurgical excision procedure (LEEP) would allow for better management of the disease. We investigated whether gene signatures could: a) associate with HPV cervical histopathology, and b) identify women with post-LEEP disease recurrence/relapse. Gene array analysis was performed on paraffin-embedded cervical tissue-isolated RNA from two cross-sectional cohorts of antiretroviral therapy (ART)-suppressed HIV+HPV+ co-infected women: a) 55 women in South Africa recruited into three groups: High risk (HR) (-) (n=16) and HR (+) (n=15) HPV without cervical histopathology, and HR (+) HPV with Cervical Intraepithelial Neoplasia (CIN) grade 1/2/3 (n=24); b) 28 women in Botswana with CIN2/3 treated with LEEP 12-month prior to recruitment and presenting with (n=13) and without (n=15) lesion recurrence/relapse (tissue was analyzed at first LEEP)...
October 26, 2018: Carcinogenesis
Margot M Koeneman, Irene T Ovestad, Emiel A M Janssen, Monique Ummelen, Roy F P M Kruitwagen, Anton H Hopman, Arnold J Kruse
Approximately 20-40% of high-grade Cervical Intraepithelial Neoplasia (CIN) regresses spontaneously, but the natural prognosis of an individual lesion is unpredictable. Gain of the chromosomal 3q region, which contains the human telomerase RNA gene on 3q26, is found in CIN lesions and cervical carcinoma and shows correlation with disease grade. The aim of this study is to assess whether 3q26 gain as a single genetic marker can predict the natural prognosis of high-grade CIN, by performing a review of the literature and pilot study...
October 25, 2018: Pathology Oncology Research: POR
Renée M F Ebisch, Pleun J W Ketelaars, Wouter M H van der Sanden, Channa E Schmeink, Charlotte H Lenselink, Albert G Siebers, Leon F A G Massuger, Willem J G Melchers, Ruud L M Bekkers
INTRODUCTION: Screening of young women is often discouraged because of the high risk of unnecessary diagnostics or overtreatment. Multiple countries therefore use cytology instead of high risk human papillomavirus (hrHPV)-testing as screening method for young women because of the limited specificity of hrHPV-testing. The objective of this study was to investigate how hrHPV screening before the age of 30, can be used to reduce the future prevalence of high-grade cervical lesions in young women...
2018: PloS One
Tracy R Shachner, Stuart E Van Meter
Metastatic cancer involving the uterine cervix is exceedingly rare, and accounts for less than 1% of cancer deaths. The cervix is an uncommon location for metastatic lesions due to its limited blood supply and fibrous stroma and metastatic melanoma of the cervix is particularly infrequent. To the best of our knowledge and literature review, there have only been nine reported cases in the literature of metastatic melanoma involving the uterine cervix that were diagnosed via cervicovaginal Pap smears, including the case being reported in this paper...
October 24, 2018: Diagnostic Cytopathology
Isin Ureyen, Tayfun Toptas, Aysel Uysal
BACKGROUND: In the present study, we primarily aimed to correlate the colposcopy results of patients with human papillomavirus (HPV) positivity and abnormal cervical screening results. Secondarily, we attempted to define the role of endocervical curettage (ECC) in the colposcopic evaluation of patients who had normal cytology and HPV16, which is the most carcinogenic HPV type. METHODS: This was a retrospective study analyzing the data of patients who had colposcopies between January 2015 and May 2016 in the Gynecological Oncology clinic of a single tertiary center...
October 24, 2018: Diagnostic Cytopathology
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