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Cervical intraepithelial lesions

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https://www.readbyqxmd.com/read/28074107/frequency-of-chlamydia-trachomatis-infection-in-cervical-intraepithelial-lesions-and-the-status-of-cytological-p16-ki-67-dual-staining
#1
R Robial, A Longatto-Filho, C M Roteli-Martins, M F Silveira, D Stauffert, G G Ribeiro, I M Linhares, M Tacla, M A Zonta, E C Baracat
BACKGROUND: Chlamydia trachomatis (Ct) is not a disease subject to mandatory reporting in Brazil, and the prevalence rate of this genital infection varies according to the region in which studies are conducted, as well as by the detection technique employed. Ct has been associated with persistence of Human papillomavirus (HPV) infection and the facilitation of cervical carcinoma development. We evaluated the Chlamydia trachomatis infection and its association with cytology, p16/Ki-67 dual-stained cytology and cervical intraepithelial lesions status in a screening cohort in Brazil...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28069683/targeted-deep-sequencing-reveals-full-methylation-profiles-of-multiple-hpv-types-and-potential-biomarkers-for-cervical-cancer-progression
#2
Pengyuan Liu, Marissa Iden, Samantha Fye, Yi-Wen Huang, Elizabeth Hopp, Chen Chu, Yan Lu, Janet S Rader
BACKGROUND: Invasive cervical cancer (ICC) and its premalignant phase (cervical intraepithelial neoplasia; CIN1-3) are distinguished by gynecological and pathological examination, yet no current methodologies can predict precancerous lesions that are destined to progress to ICC. Thus, development of reliable assays to assess patient prognosis is much needed. METHODS: HPV DNA methylation is significantly altered in cervical disease. Using an HPV-enrichment approach and next-generation DNA sequencing, methylation status was characterized in a case-case comparison of CIN (n = 2 CIN1; n = 2 CIN2; n = 20 CIN3) and ICC (n = 37) samples...
January 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28060456/significance-of-high-risk-hpv-detection-in-women-with-atypical-glandular-cells-on-pap-testing-analysis-of-1857-cases-from-an-academic-institution
#3
Stell Patadji, Zaibo Li, Dinesh Pradhan, Chengquan Zhao
BACKGROUND: The role of high-risk human papillomavirus (hrHPV) testing in women with various types of atypical glandular cells (AGC) on Papanicolaou (Pap) test is undetermined. METHODS: Herein, the authors retrospectively searched their pathology database for cases of AGC with concurrent hrHPV testing and histological follow-up results within 1 year between January 2008 and December 2013. RESULTS: Among 3709 AGC cases occurring during the study period, 2287 had concurrent Hybrid Capture 2 HPV testing results...
October 24, 2016: Cancer
https://www.readbyqxmd.com/read/28059468/gene-expression-analysis-combined-with-functional-genomics-approach-identifies-itih5-as-tumor-suppressor-gene-in-cervical-carcinogenesis
#4
Jessica Dittmann, Angelique Ziegfeld, Lars Jansen, Mieczyslaw Gajda, Vera Kloten, Edgar Dahl, Ingo B Runnebaum, Matthias Dürst, Claudia Backsch
Progression from human papillomavirus-induced premalignant cervical intraepithelial neoplasia (CIN) to cervical cancer (CC) is driven by genetic and epigenetic events. Our microarray-based expression study has previously shown that inter-α-trypsin-inhibitor heavy chain 5 (ITIH5) mRNA levels in CCs were significantly lower than in high-grade precursor lesions (CIN3s). Therefore, we aimed to analyze in depth ITIH5 expression during cervical carcinogenesis in biopsy material and cell culture. Moreover, functional analyses were performed by ectopic expression of ITIH5 in different cell lines...
January 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28052328/type-dependent-association-between-risk-of-cervical-intraepithelial-neoplasia-and-viral-load-of-oncogenic-human-papillomavirus-types-other-than-types-16-and-18
#5
Long Fu Xi, Mark Schiffman, Yang Ke, James P Hughes, Denise A Galloway, Zhonghu He, Ayaka Hulbert, Rachel L Winer, Laura A Koutsky, Nancy B Kiviat
Studies of the clinical relevance of human papillomavirus (HPV) DNA load have focused mainly on HPV16 and HPV18. Data on other oncogenic types are rare. Study subjects were women enrolled in the Atypical Squamous Cells of Undetermined Significance (ASC-US) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals. Viral load measurements were performed on the first type-specific HPV-positive specimens...
January 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28051906/clinicopathological-significance-of-survivin-expression-in-patients-with-cervical-cancer-a-systematic-meta-analysis
#6
Yibing Fan, Juan Chen
BACKGROUND: Survivin has been shown to play an important role in cancer pathogenesis. However, its role in cervical cancer development is still controversial. This study was performed to evaluate the clinical significance of survivin expression in cervical cancer. METHODS: Search of some online electronic databases was conducted to identify available studies. The pooled odds ratios (ORs) with its 95% confidence intervals (CIs) were calculated and analyzed. RESULTS: Finally, 18 eligible studies with 791 cervical cancer patients, 1,013 cervical intraepithelial neoplasia (CIN) lesions, 199 normal cervical tissues, and 95 samples with chronic cervicitis were identified in this analysis...
January 4, 2017: Bioengineered
https://www.readbyqxmd.com/read/28040505/dlg1-polarity-protein-expression-associates-with-the-disease-progress-of-low-grade-cervical-intraepithelial-lesions
#7
Ana Laura Cavatorta, Alejandra Di Gregorio, Marina Bugnon Valdano, Federico Marziali, Mariela Cabral, Hebe Bottai, Jorge Cittadini, Ana Lia Nocito, Daniela Gardiol
Human Discs large tumour suppressor (DLG1) participates in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. However, it was demonstrated that DLG1 could acquire oncogenic attributes in some specific contexts. In this work, we evaluated the expression of DLG1 and its contribution to the progress of cervical lesions in order to investigate a potential role of this polarity protein in human oncogenic processes. We analyzed cervical biopsies from women with low-grade squamous intraepithelial lesion (LSIL) diagnosis (n=30), for DLG1 expression by immunohistochemistry...
December 29, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28039412/cervical-neoplasia-in-systemic-lupus-erythematosus-a-nationwide-study
#8
Hjalmar Wadström, Elizabeth V Arkema, Christopher Sjöwall, Johan Askling, Julia F Simard
OBJECTIVE: The aim was to examine the risk of cervical neoplasia in women with SLE, overall and with respect to treatment, compared with women from the general population. METHODS: By linking national Swedish registers, we assembled a cohort including women with SLE (n = 4976) and matched general population comparators (n = 29 703). Two subcohorts of treated SLE patients were defined on the basis of treatment with antimalarials (n = 1942) and other immunosuppressants (AZA, CYC, ciclosporin, MTX, MMF or rituximab; n = 2175)...
December 30, 2016: Rheumatology
https://www.readbyqxmd.com/read/28029192/factors-related-to-inter-observer-reproducibility-of-conventional-pap-smear-cytology-a-multilevel-analysis-of-smear-and-laboratory-characteristics
#9
A Baena, E Guevara, M Almonte, J Arias-Stella, P Sasieni, G I Sanchez
OBJECTIVE: To identify factors that influence the inter-observer reproducibility of the routine, conventional Pap smear cytology (Pap smear test) in a network of certificated laboratories in a middle-income Latin American country. METHODS: Twenty-six laboratories provided each an average of 26 negative for malignancy (NILM) and high-grade squamous intraepithelial lesion (HSIL) Pap smears. An external panel reviewed the slides. The kappa index and multilevel logistic regression were used to estimate the reproducibility and odds ratios (OR) of a false result with 95% confidence intervals (95% CI), respectively...
December 28, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28026078/screening-for-cervical-carcinoma-in-hiv-infected-women-analysis-of-main-risk-factors-for-cervical-cytologic-abnormalities
#10
Matilde Sansone, Gabriele Saccone, Annalisa Migliucci, Rosa Saviano, Angela Capone, Giuseppe Maria Maruotti, Dario Bruzzese, Pasquale Martinelli
AIM: The aim of this study was to identify potential predictive factors for cervical disease in women with HIV and to evaluate adherence during follow-up to cervical cancer screening. METHODS: In order to identify the independent role of factors associated with the presence of a cervical abnormality, all of the variables showing in univariate analyses a potential association with the outcome variable (presence of cervical abnormalities) were entered into a multivariate logistic regression model, along with age at first visit to our center, and age at diagnosis...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28009429/association-between-toll-like-receptor-and-tumor-necrosis-factor-immunological-pathways-in-uterine-cervical-neoplasms
#11
Lucas G G de Matos, Eduardo B Cândido, Paula V T Vidigal, Polyanna H C Bordoni, Rivia M Lamaita, Márcia M Carneiro, Agnaldo L da Silva-Filho
INTRODUCTION: The immune system plays a critical role in the defense against human papillomavirus (HPV) infection and its persistence. Toll-like receptors (TLRs) are membrane receptors responsible for activation of the innate immune response, and an association between TLR expression and uterine cervical cancer has been shown. Tumor necrosis factors (TNFs) are among the main mediators of skin and mucosa inflammation. The aim of this study was to demonstrate the association between TLR and TNF immune expression and cervical cancer and premalignant cervical lesions...
November 15, 2016: Tumori
https://www.readbyqxmd.com/read/28002084/use-of-visual-inspection-with-acetic-acid-pap-smear-or-high-risk-human-papillomavirus-testing-in-women-living-with-hiv-aids-for-posttreatment-cervical-cancer-screening-same-tests-different-priorities
#12
Elkanah Omenge Orang'o, Tao Liu, Astrid Christoffersen-Deb, Peter Itsura, John Oguda, Sierra Washington, David Chumba, Latha Pisharodi, Susan Cu-Uvin, Anne F Rositch
OBJECTIVES: Few studies have addressed optimal follow-up for HIV-infected women after cervical treatment. This study aimed to compare performance of three available tests to detect posttreatment cervical disease in HIV-infected women in Kenya. DESIGN: This is a prospective cohort study. METHODS: At least 6 months following cryotherapy, 517 HIV-infected women were evaluated concurrently with visual inspection with acetic acid (VIA), papanicolaou (Pap) smear, and high-risk human papillomavirus (HR-HPV) testing...
January 14, 2017: AIDS
https://www.readbyqxmd.com/read/27998803/a-pilot-study-on-hla-g-locus-control-region-haplotypes-and-cervical-intraepithelial-neoplasias
#13
Juliana Cochesnki Cordeiro, Jose Samuel da Silva, Valeria Sperandio Roxo, Maria da Graça Bicalho
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasias (CIN) grades 1, 2 and 3. Untreated, these lesions may progress to cervical cancer (CC) which is the third most common cancer in women worldwide. HLA-G plays an immunotolerant role in the immune response. The aim of this study was to characterize the configuration of SNPs located at the distal promoter of HLA-G in patients with CIN2 and CIN3 and control women. The study sample was composed of 207 women as follows: 73 diagnosed with CIN2 lesions, 56 with CIN3 and 78 healthy control women...
December 17, 2016: Human Immunology
https://www.readbyqxmd.com/read/27998415/-effects-of-both-folic-acid-p16-protein-expression-and-their-interaction-on-progression-of-cervical-cancerization
#14
W L Jia, L Ding, Z Y Ren, T T Wu, W M Zhao, S L Fan, J T Wang
Objective: To explore the effects of both folic acid, p16 protein expression and their interaction on progression of cervical cancerization. Methods: Participants were pathologically diagnosed new cases, including 80 women with normal cervical (NC), 55 patients with low-grade cervical intraepithelial neoplasia (CINⅠ), 55 patients with high-grade cervical intraepithelial neoplasia (CINⅡ/Ⅲ) and 64 patients with cervical squamous cell carcinoma (SCC). Serum folate levels were detected by microbiological assay method while p16 protein expression levels were measured by Western-blot...
December 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27997455/cervical-cancer-screening-with-human-papillomavirus-dna-and-cytology-in-japan
#15
Yuri Sasaki, Osamu Iwanari, Ichiro Arakawa, Takuya Moriya, Yoshiki Mikami, Kuniko Iihara, Ryo Konno
OBJECTIVE: The aim of this study was to determine the value of human papillomavirus (HPV) testing for primary cervical cancer screening in Japan. METHODS: In total, 5065 women who underwent primary screening with cytology and HPV between January 2005 and December 2006 were enrolled. In the baseline phase, these women were stratified by age, and the rates of HPV-positive and abnormal cytology were compared between women younger than and older than 30 years. In the follow-up phase, women aged 20 to 69 years and cytology negative for intraepithelial lesions or malignancy at baseline were followed up until December 2011 (n = 2383)...
December 16, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27965301/high-rates-of-anal-high-grade-squamous-intraepithelial-lesions-in-hiv-infected-women-who-do-not-meet-screening-guidelines
#16
Michael Gaisa, Fanny Ita-Nagy, Keith Sigel, Yotam Arens, Mary Ann Hennessy, Gabriela Rodriguez-Caprio, Michael Mullen, Judith A Aberg, Michelle Cespedes
BACKGROUND: Human immunodeficiency virus (HIV)-infected women have a higher burden of anal high-grade squamous intraepithelial lesions (HSIL) and anal cancer (AC) compared with HIV-uninfected women. Guidelines for AC screening in this population are heterogeneous. Here we report outcomes and risk factors for anal HSIL following implementation of universal AC screening offered to all HIV-infected women. METHODS: Data from women who underwent AC screening with anal cytology from April 2009 to July 2014 were analyzed...
November 9, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27933097/molecular-mechanisms-of-hpv-mediated-neoplastic-progression
#17
REVIEW
Rashmirani Senapati, Nihar Nalini Senapati, Bhagirathi Dwibedi
Human Papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. Despite significant research, the underlying mechanisms of progression from a low-grade squamous intraepithelial lesion to high grade squamous intraepithelial lesion are yet to be understood. Deregulation of viral gene expression and host genomic instability play a central role in virus-mediated carcinogenesis. Key events such as viral integration and epigenetic modifications may lead to the deregulation of viral and host gene expression...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27928861/new-diagnostic-criteria-of-colposcopy-for-uterine-cervix-neoplasia
#18
Masamichi Kashimura, Yusuke Matsuura, Toshinori Kawagoe, Naoyuki Toki, Toru Hachisuga
AIM: The purpose of this study is to present alternative diagnostic criteria of colposcopy using new parameters. METHODS: Colposcopic photographs were reviewed in 1649 patients from the past 23 years, including 283 benign lesions, 327 low-grade squamous intraepithelial lesions (LSIL; cervical intraepithelial neoplasia 1), 549 high-grade squamous intraepithelial lesions (HSIL; cervical intraepithelial neoplasia 2/3), 78 microinvasive cancers, and 412 invasive cancers...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27917752/genetic-and-environmental-factors-in-invasive-cervical-cancer-design-and-methods-of-a-classical-twin-study
#19
Dorothy A Machalek, John D Wark, Sepehr N Tabrizi, John L Hopper, Minh Bui, Gillian S Dite, Alyssa M Cornall, Marian Pitts, Dorota Gertig, Bircan Erbas, Suzanne M Garland
BACKGROUND: Persistent high-risk human papillomavirus (HPV) infection is a necessary prerequisite for development of cervical cancer and its precursor lesion, high-grade squamous intraepithelial lesion (HSIL). However, HPV infection is not sufficient to drive this process, and genetic and environmental factors may also play a role. METHODS/DESIGN: The Cervical Cancer, Genetics and Environment Twin Study was established to investigate the environmental and genetic influences on variation in susceptibility to cervical pre-cancer in 25- to 69-year-old monozygotic (MZ) and dizygotic (DZ) twins recruited through the Australian Twin Registry...
December 5, 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27908632/risk-of-persistent-and-recurrent-cervical-neoplasia-following-incidentally-detected-adenocarcinoma-in-situ
#20
Aime Munro, Jim Codde, Katrina Spilsbury, Nerida Steel, Colin J R Stewart, Stuart G Salfinger, Jason Tan, Ganendra R Mohan, Yee Leung, James Semmens, Peter O'Leary, Vincent Williams, Paul A Cohen
BACKGROUND: Adenocarcinoma in situ of the uterine cervix is a precursor to cervical adenocarcinoma and may coexist with both adenocarcinoma and high-grade squamous dysplasia (cervical intraepithelial neoplasia 2 and 3). Up to 60% of adenocarcinoma in situ lesions are detected incidentally following excisional biopsies performed for the treatment of cervical intraepithelial neoplasia 2/3. To date there are no data regarding risk factors for persisting or progressive cervical neoplasia in these patients...
November 28, 2016: American Journal of Obstetrics and Gynecology
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