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Cervical intraepithelial lesions

Jiafeng Pan, Kimberley Kavanagh, Kate Cuschieri, Kevin G Pollock, Duncan C Gilbert, David Millan, Sarah Bell, Sheila V Graham, Alistair R W Williams, Margaret E Cruickshank, Tim Palmer, Katie Wakeham
To assess the excess risk of HPV-associated cancer (HPVaC) in two at-risk groups - women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non-cervical pre-invasive ano-genital disease. All CIN3 cases diagnosed in 1989-2015 in Scotland were extracted from the Scottish cancer registry (SMR06). All cases of pre-invasive penile, anal, vulval, and vaginal disease diagnosed in 1990-2015 were identified within the NHS pathology databases in the two largest NHS health boards in Scotland...
January 16, 2019: International Journal of Cancer. Journal International du Cancer
Mark H Stoler, Thomas C Wright, Valentin Parvu, Karen Yanson, Karen Eckert, Salma Kodsi, Charles Cooper
Objectives: To determine the BD Onclarity human papillomavirus (HPV) assay performance and risk values for cervical intraepithelial neoplasia grade 2 (CIN2) or higher and cervical intraepithelial neoplasia grade 3 (CIN3) or higher during Papanicolaou/HPV cotesting in a negative for intraepithelial lesions or malignancies (NILM) population. Methods: In total, 22,383 of the 33,858 enrolled women were 30 years or older with NILM cytology. HPV+ and a subset of HPV- patients (3,219/33,858 combined; 9...
January 14, 2019: American Journal of Clinical Pathology
Jung-Soo Pyo, Guhyun Kang, Hye Kyoung Yoon, Hyun Jung Kim
Background: Even though cervico-vaginal smears have been used as a primary screening test for cervical carcinoma, the diagnostic accuracy has been controversial. The present study aimed to evaluate the diagnostic accuracy of cytology for squamous intraepithelial lesion (SIL) and squamous cell carcinoma (SqCC) of the uterine cervix through a diagnostic test accuracy (DTA) review. Methods: A DTA review was performed using 38 eligible studies that showed concordance between cytology and histology...
January 14, 2019: Journal of Korean Medical Science
Cecilie Dovey de la Cour, Sonia Guleria, Mari Nygård, Laufey Trygvadóttir, Kristjan Sigurdsson, Kai-Li Liaw, Maria Hortlund, Camilla Lagheden, Bo T Hansen, Christian Munk, Joakim Dillner, Susanne K Kjaer
It is valuable to establish a population-based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high-grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four countries (Denmark, Norway, Sweden, and Iceland), we collected consecutive series of cervical cancers (n = 639) and high-grade precancerous cervical lesions (n = 1240) during 2004-2006 before implementation of HPV vaccination and subjected the specimens to standardized HPV genotyping...
January 11, 2019: Cancer Medicine
Tamy Tiemi Suehiro, Natália Malaguti, Edilson Damke, Nelson Shozo Uchimura, Fabrícia Gimenes, Raquel Pantarotto Souza, Vânia Ramos Sela da Silva, Marcia Edilaine Lopes Consolaro
OBJECTIVE: To assess the rates of co-infections between human papillomavirus (HPV) and 13 key markers of bacterial vaginosis in cervical samples by multiplex polymerase chain reaction in a population with a high rate of abnormal cytology and a positive HPV test. METHODS: The study included a total of 213 women aged 18-72 years screened using Papanicolaou smears for determining cervical abnormalities and for HPV and bacterial vaginosis by single-target and multiplex polymerase chain reaction...
January 10, 2019: International Journal of Gynecological Cancer
Julie T Christensen, Christian Grønhøj, Martin Zamani, Julie Brask, Eva K R Kjær, Henrik Lajer, Christian von Buchwald
BACKGROUND: Persistent infection with high-risk genotypes of human papillomavirus (HPV) is the main risk factor in the development of uterine cervical precancerous lesions and cervical cancer (CC), and cases of HPV-induced oropharyngeal squamous cell carcinoma (OPSCC) is increasing in the Western world. We investigated the association between HPV and p16 status and previous results of cervical examinations, including cytological and histological tests, in females with OPSCC. MATERIAL AND METHODS: We included females diagnosed with an OPSCC in Eastern Denmark from 2000 to 2014...
January 9, 2019: Acta Oncologica
T Gogoladze, V Tkeshelashvili, T Alibegashvili, M Jorbenadze, K Manjgaladze
The purpose of this study was to determine the diagnostic value Pap smear test and colposcopy in Georgian National Screening Center, evaluation of efficiency of the excisional treatment and determining the main risk factors for prediction of residual/recurrent disease in patients with high-grade cervical intraepithelial neoplasia. We retrospectively analyzed 613 patients, who underwent excisional treatment of the cervix (LEEP). Follow-up was performed by Pap smear test, colposcopy and histamorphological examinations...
November 2018: Georgian Medical News
Wiyada Dankai, Surapan Khunamornpong, Sumalee Siriaunkgul, Aungsumalee Soongkhaw, Arphawan Janpanao, Utaiwan Utaipat, Nakarin Kitkumthorn, Apiwat Mutirangura, Jatupol Srisomboon, Suree Lekawanvijit
Cervical cancer is the fourth most common malignancy affecting women worldwide. The development of disease is related to high-risk human papillomavirus (hrHPV) infection. Cytology has been the most recommended triage for primary cervical (pre)cancer screening despite relatively low sensitivity. Recently, genomic DNA methylation has been proposed as an additional marker to increase sensitivity for detecting cervical precancerous lesion. This study aimed to evaluate the performance of methylation status of three tumor suppressor genes (CADM1, FAM19A4, and MAL) and HPV genotyping in detection of cytologic and histologic abnormalities in cervical cancer screening...
2019: PloS One
Katrina Mark, Anja Frost, Heather Hussey, Micael Lopez-Acevedo, Anne E Burke, Jill Edwardson, Opey Solaru, Patti Gravitt
PURPOSE: To determine rates and factors associated with regression of cervical intraepithelial neoplasia (CIN) 2 + between colposcopic biopsy and therapeutic excisional procedure in standard practice. METHODS: A retrospective chart review was performed for women undergoing a cervical excisional procedure for CIN 2 + at clinics at three academic institutions over a 3-year period. Cytology, histology, patient age and time-to-excision were analyzed to determine factors influencing rates of regression...
January 4, 2019: Archives of Gynecology and Obstetrics
Ferenc Zoltan Takacs, Julia Caroline Radosa, Florian Bochen, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Rainer M Bohle, Georg-Peter Breitbach, Bernard Schick, Maximilian Linxweiler
PURPOSE: The aim of this study was to analyze the diagnostic performance of a newly established immunocytochemical dual-staining protocol for the simultaneous expression of SEC62 and Ki67 in vulvar liquid-based cytology specimens for the identification of vulvar intraepithelial neoplasia (VIN) and vulvar cancer. In addition, we investigated the p16/Ki67 dual stain, which has already been established in cervical cytology. MATERIALS AND METHODS: For this pilot study, residual material from liquid-based cytology was collected retrospectively from 45 women...
January 4, 2019: Archives of Gynecology and Obstetrics
G Z Guo, Y Zhao
Objective: To analyze the screening results of cervical cancer in elderly women in Beijing and Guizhou. To compare the screening effectiveness of cervical cancer in elderly women in different areas. Methods: A retrospective analysis was performed on the screening data of elderly women (≥50 years) who had examination at cervical lesion clinic in Peking University People's Hospital and Affiliated Hospital of Guizhou Medical University from January 2013 to January 2014, with histopathology as the gold standard, to compare screening effectiveness of cervical cytology or HPV detection for elderly women in cervical cancer screening in the two regions...
December 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Yutao Ma, Tao Xu, Xiaolei Huang, Xiaofang Wang, Canyu Li, Jason Jerwick, Yuan Ning, Xianxu Zeng, Baojin Wang, Yihong Wang, Zhan Zhang, Xiaoan Zhang, Chao Zhou
OBJECTIVE: Ultrahigh-resolution optical coherence microscopy (OCM) has recently demonstrated its potential for accurate diagnosis of human cervical diseases. One major challenge for clinical adoption, however, is the steep learning curve clinicians need to overcome to interpret OCM images. Developing an intelligent technique for computer-aided diagnosis (CADx) to accurately interpret OCM images will facilitate clinical adoption of the technology and improve patient care. METHODS: 497 high-resolution 3-D OCM volumes (600 cross-sectional images each) were collected from 159 ex vivo specimens of 92 female patients...
January 1, 2019: IEEE Transactions on Bio-medical Engineering
Baowen Zheng, Huaitao Yang, Zaibo Li, Jia You, Guijian Wei, Huina Zhang, Zhengyu Zeng, Fengxiang Xie, Chengquan Zhao
CONTEXT.—: Reports for atypical squamous cells of undetermined significance (ASC-US) and histologic findings are rare in China. OBJECTIVE.—: To analyze the correlation findings of ASC-US cytology with high-risk human papillomavirus (hrHPV) test and histopathologic follow-ups. DESIGN.—: ASC-US cases with hrHPV test and histologic follow-ups between 2011 and 2015 were analyzed at a College of American Pathologists-certified laboratory...
December 28, 2018: Archives of Pathology & Laboratory Medicine
Min-A Kim, Gwan Hee Han, Jae-Hoon Kim, Kyung Seo
Human Papillomavirus (HPV) infection is the most common sexually transmitted infection and is associated with the development of cervical cancer. The purpose of this report is to provide the literature evidences on selecting the HPV vaccine for national immunization program (NIP) in Korea. To complete these tasks, we reviewed domestic and foreign literature on the current status of HPV infection, efficacy and effectiveness of HPV vaccine, safety of vaccine and cost effectiveness analysis of vaccination business...
December 24, 2018: Journal of Korean Medical Science
Philip E Castle, Walter K Kinney, Xiaonan Xue, Li C Cheung, Julia C Gage, Nancy E Poitras, Thomas S Lorey, Hormuzd A Katki, Nicolas Wentzensen, Mark Schiffman
Background: Cervical cancer is caused by persistent human papillomavirus (HPV) infection. US consensus management guidelines for a positive cervical screening result typically focus on the current screening result only. A negative testing history may alter risk of the following positive screening results, caused by a new HPV infection, and therefore its optimal management. Methods: Women ages 30 years and older were screened with triennial HPV and cytology co-testing at Kaiser Permanente Northern California from 2003 to 2014...
December 21, 2018: Journal of the National Cancer Institute
Jung Mi Byun, Dae Hoon Jeong, Young Nam Kim, Eun Jung Jung, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim
High-grade cervical intraepithelial neoplasia (CIN) is a precancerous lesion of cervical cancer. The aims of this study were to evaluate the risk factors for recurrence of high-grade CIN and to determine if the specific genotype of human papillomavirus (HPV) is a predictor of recurrent high-grade CIN. Between January 2010 and December 2014, 172 patients with CIN 2+ underwent cold knife conization or a loop electrosurgical excision. The HPV DNA chip was used to detect HPV. Recurrent lesions were histologically confirmed and considered to be recurrence of CIN2+...
December 2018: Medicine (Baltimore)
L Ding, M J Feng, C L Liu, L Wang, Z C Song, Q Yang, X X Li, L Song, W Gao, J T Wang
Objective: To investigate the effect of heterogeneous nuclear ribonucleoprotein K (hnRNP K) and its interaction with human papillomavirus 16 (HPV16) on cervical intraepithelial neoplasia (CIN). Methods: The participants included 67 women with normal cervix (NC), 69 women with CINⅠ and 68 women with CINⅡ/Ⅲ in a community cohort of pathologically diagnosed women established in Jiexiu of Shanxi province, from June 2014 to June 2015. A structured questionnaire was used to collect the demographic data of the subjects and the related factors of cervical lesions...
December 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Xiaofen Zhan, Shaohong Wang, Xuan Wu, Xiaoyang Qiu, Fan Li, Yunzhu Zeng, Zhiqiang Chen
Objective To investigate the diagnostic value of human papillomavirus (HPV) E6/E7 mRNA combined with P16/antigen KI-67(ki67) immunocytochemical double staining in the atypical squamous cells of undetermined significance (ASCUS). Methods A total of 272 patients were selected and the results of HPV E6/E7 and P16/ki67 immunocytochemical double staining in the remaining cytological specimens were retrospectively analyzed. HPV E6/E7 gene was detected by HPV E6/E7 gene detection kit and Panther molecular diagnostic instrument...
October 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Zhihong Min, Xiaowen Pu, Zhengrong Gu
This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. At the same time, 30 cases of chronic cervicitis were selected as the control group...
December 2018: Oncology Letters
Sandra Meršaková, Veronika Holubeková, Marián Grendár, Jozef Višňovský, Marcela Ňachajová, Michal Kalman, Erik Kúdela, Pavol Žúbor, Tibor Bielik, Zora Lasabová, Ján Danko
Cervical cancer (CC) is the second most common type of cancer affecting the female population. The development of CC takes several years, and involves a precancerous stage known as cervical intraepithelial neoplasia (CIN). A key factor in the development of disease is the human papillomavirus (HPV) infection, which initiates carcinogenesis. Furthermore, CC is also impacted by epigenetic changes such as DNA methylation, which causes activation or exclusion of certain genes, and the hypermethylation of cytosines in promoters, thereby switching off previously active genes...
December 2018: Oncology Letters
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