keyword
MENU ▼
Read by QxMD icon Read
search

Cervical intraepithelial lesions

keyword
https://www.readbyqxmd.com/read/28288568/deep-sequencing-of-hpv-e6-e7-genes-reveals-loss-of-genotypic-diversity-and-gain-of-clonal-dominance-in-high-grade-intraepithelial-lesions-of-the-cervix
#1
Jane Shen-Gunther, Yufeng Wang, Zhao Lai, Graham M Poage, Luis Perez, Tim H M Huang
BACKGROUND: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. HPV genotyping by dideoxy (Sanger) sequencing is currently the reference method of choice for clinical diagnostics. However, for samples with multiple HPV infections, genotype identification is singular and occasionally imprecise or indeterminable due to overlapping chromatograms. Our aim was to explore and compare HPV metagenomes in abnormal cervical cytology by deep sequencing for correlation with disease states...
March 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28283546/functional-association-of-oestrogen-receptors-with-hpv-infection-in-cervical-carcinogenesis
#2
REVIEW
Balaji Ramachandran
Repeated parity and usage of oral contraceptives have demonstrated an increased risk of cervical cancer (CC) in HPV-infected women. These lifestyle observations raise the likelihood that oestrogens and HPV infection might act synergistically to affect cancers of the cervix. In vivo studies have indicated the requirement of oestrogens and ERα in the development of atypical squamous metaplasia followed by cervical intraepithelial neoplasia (CIN) I, II and III. CIN II and III are precancerous cervical lesions that can progress over time to CC as an invasive carcinoma...
April 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28272675/what-does-the-data-of-354-725-patients-from-turkey-tell-us-about-cervical-smear-epithelial-cell-abnormalities-the-epithelial-cell-abnormality-rate-is-increasing-quality-control-studies-and-corrective-activity-are-musts
#3
İlknur Çetinaslan Türkmen, Alp Usubütün, Aslı Çakir, Özlem Aydin, Filiz Aka Bolat, Metin Akbulut, Serdar Altinay, Sema Arici, Figen Aslan, Müzeyyen Astarci, Emine Kılıç Bağir, Yılmaz Baş, Nuray Başsüllü, Betül Çelik, Handan Çetiner, Bengü Çobanoğlu, Abdullah Aydin, Hale Demir, Hayriye Tatlı Doğan, Kamile Gülçin Eken, Selma Şengiz Erhan, Gülgün Erdoğan, Kıvılcım Eren Erdoğan, Funda Eren, Şafak Ersöz, Pınar Firat, İclal Gürses, Nihan Haberal, Dudu Solakoğlu Kahraman, Gülçin Harman Kamali, Yasemin Yuyucu Karabulut, Mehmet Kefeli, Meral Koyuncuoğlu, R Doğan Köseoğlu, Bahar Müezzinoğlu, Binnur Onal, Sevgen Önder, Zuhal Özcan, Elife Kimiloğlu, Hatice Özer, F Cavide Sönmez, Sevinç Şahin, Nurhan Şahin, Tülin Yalta
OBJECTIVE: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. MATERIAL AND METHOD: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28271661/human-papillomavirus-hpv-e6-e7-mrna-detection-in-cervical-exfoliated-cells-a-potential-triage-for-hpv-positive-women
#4
Ye-Li Yao, Qi-Fang Tian, Bei Cheng, Yi-Fan Cheng, Jing Ye, Wei-Guo Lu
Cytology triage has been generally recommended for human papillomavirus (HPV)-positive women, but is highly dependent on well-trained cytologists. The present study was designed to explore whether HPV E6/E7 mRNA detection in cervical exfoliated cells can be a potential triage for HPV-positive women from a clinic-based population. Both the primary HPV testing and Papanicolaou (Pap) test were performed on all eligible HPV-positive women. HPV E6/E7 mRNA was detected by QuantiVirus(®) HPV E6/E7 mRNA assay in cervical exfoliated cells...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28271660/prognostic-value-of-human-papillomavirus-16-18-genotyping-in-low-grade-cervical-lesions-preceded-by-mildly-abnormal-cytology
#5
Jing Ye, Bei Cheng, Yi-Fan Cheng, Ye-Li Yao, Xing Xie, Wei-Guo Lu, Xiao-Dong Cheng
Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. In this study, we assessed the triage value of human papillomavirus (HPV) 16/18 genotyping in 273 patients with LSIL/CIN1. HPV16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. At each follow-up, women positive for cytology or high-risk HPV (hrHPV) were referred for colposcopy...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28270915/options-in-human-papillomavirus-hpv-detection-for-cervical-cancer-screening-comparison-between-full-genotyping-and-a-rapid-qualitative-hpv-dna-assay-in-ghana
#6
Dorcas Obiri-Yeboah, Yaw Adu-Sarkodie, Florencia Djigma, Kafui Akakpo, Ebenezer Aniakwa-Bonsu, Daniel Amoako-Sakyi, Simpore Jacques, Philippe Mayaud
BACKGROUND: Modern cervical cancer screening increasingly relies on the use of molecular techniques detecting high-risk oncogenic human papillomavirus (hr-HPV). A major challenge for developing countries like Ghana has been the unavailability and costs of HPV DNA-based testing. This study compares the performance of careHPV, a semi-rapid and affordable qualitative detection assay for 14 hr-HPV genotypes, with HPV genotyping, for the detection of cytological cervical squamous intraepithelial lesions (SIL)...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28270859/genetic-variability-in-e6-e7-and-l1-genes-of-human-papillomavirus-62-and-its-prevalence-in-mexico
#7
Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy
BACKGROUND: Human papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV genotypes is associated with premalignant lesions and cervical cancer development. HPVs considered as low risk or not yet classified, are often found in coinfection with different HPV genotypes. Indeed, HPV62 is one of the most prevalent HPV detected in some countries, but there is limited information about its prevalence in other regions and there are no HPV62 variants currently described...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28264203/underdiagnosis-of-cervical-intraepithelial-neoplasia-cin-2-or-worse-lesion-in-women-with-a-previous-colposcopy-guided-biopsy-showing-cin-1
#8
Carlos André Scheler de Souza, Michelle Garcia Discacciati, Maria Gabriela d'Otavianno, Silvia Maria Bergo, Markus Traue, Liliana Aparecida Lucci de Angelo Andrade, Luiz Carlos Zeferino
Objective Expectant follow-up for biopsy-proven cervical intraepithelial neoplasia (CIN) 1 is the current recommendation for the management of this lesion. Nevertheless, the performance of the biopsy guided by colposcopy might not be optimal. Therefore, this study aimed to calculate the rate of underdiagnoses of more severe lesions in women with CIN 1 diagnosis and to evaluate whether age, lesion extent and biopsy site are factors associated with diagnostic failure. Methods Eighty women with a diagnosis of CIN 1 obtained by colposcopy-guided biopsy were selected for this study...
March 6, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28263237/international-image-concordance-study-to-compare-a-point-of-care-tampon-colposcope-with-a-standard-of-care-colposcope
#9
Jenna L Mueller, Elizabeth Asma, Christopher T Lam, Marlee S Krieger, Jennifer E Gallagher, Alaattin Erkanli, Roopa Hariprasad, J S Malliga, Lisa C Muasher, Bariki Mchome, Olola Oneko, Peyton Taylor, Gino Venegas, Anthony Wanyoro, Ravi Mehrotra, John W Schmitt, Nimmi Ramanujam
OBJECTIVE: Barriers to cervical cancer screening in low-resource settings include lack of accessible, high-quality services, high cost, and the need for multiple visits. To address these challenges, we developed a low-cost, intravaginal, optical cervical imaging device, the point-of-care tampon (POCkeT) colposcope and evaluated whether its performance is comparable with a standard-of-care colposcope. MATERIALS AND METHODS: There were 2 protocols, which included 44 and 18 patients...
March 3, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28255767/follow-up-in-women-with-biopsy-diagnosis-of-cervical-low-grade-squamous-intraepithelial-lesion-lsil-how-long-should-it-be
#10
Andrea Ciavattini, Nicolò Clemente, Dimitrios Tsiroglou, Francesco Sopracordevole, Matteo Serri, Giovanni Delli Carpini, Maria Papiccio, Paolo Cattani
AIM: To analyse the regression rate and the risk of persistence or progression of the lesions in women with a histopathological diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL). MATERIALS AND METHODS: Retrospective cohort study of women with biopsy diagnosis of cervical LSIL, from January 2010 to December 2013. After the initial diagnosis of LSIL, all the women underwent scheduled follow-up examinations with cytology every 6 months for 2 years and an HPV test after 1 year...
March 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28255426/anal-intraepithelial-neoplasia-a-review-of-diagnosis-and-management
#11
REVIEW
Joseph R Roberts, Lacey L Siekas, Andrew M Kaz
Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus (HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior...
February 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28247516/introduction-of-liquid-based-cytology-and-human-papillomavirus-testing-in-cervical-cancer-screening-in-luxembourg
#12
Ardashel Latsuzbaia, Gaëtan Hebette, Marc Fischer, Marc Arbyn, Steven Weyers, Philippe Vielh, Fernando Schmitt, Joël Mossong
BACKGROUND: In 2014, liquid-based cytology with HPV triage replaced conventional cytology. The aim of our study was to compare conventional and liquid-based cytology (LBC), estimate the prevalence of abnormal cervical cytology and high risk HPV (hrHPV) infection and their correlation, among screened women in Luxembourg. METHODS: Between the first January 2013 and 31st December 2015, 315,868 cervical samples from 150,815 women (mean age 42.2 years) were investigated by the national cytology laboratory...
March 1, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28244884/triaging-atypical-squamous-cells-cannot-exclude-high-grade-squamous-intraepithelial-lesion-with-p16-ki67-dual-stain
#13
Daja Šekoranja, Alenka Repše Fokter
OBJECTIVES: The management of women with Pap cytology results categorized as "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" (ASC-H) can often be challenging. We assessed the performance of p16/Ki67 dual-stained cytology as a potential triage tool for the detection of biopsy-confirmed high-grade squamous intraepithelial lesions (HSILs) in women with ASC-H. MATERIALS AND METHODS: Women with ASC-H were followed for a period of 36 months by repeat cytology and colposcopy...
February 27, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28226009/cervical-cancer-screening-in-teresina-piau%C3%A3-brazil-evaluation-study-using-data-of-the-cervical-cancer-information-system-2006-2013
#14
Andressa Moura Damacena, Laércio Lima Luz, Inês Echenique Mattos
OBJECTIVE: to assess the cervical cancer screening tests in Teresina, Piauí, Brazil. METHODS: this is an evaluation study of Teresina Cervical Cancer Information System (Siscolo), for the period from 2006 to 2013, based on descriptive statistical analyses. RESULTS: 604,331 pap smear tests of women residents in Teresina were registered on the system; 1.8% presented premalignant or malignant cytological conditions (atypical cells, intraepithelial lesions and cancer); positive results were higher among women aged >64 years old; there was a reduction of 43...
January 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28217933/cytology-of-the-neovagina-in-transgender-women-and-individuals-with-congenital-or-acquired-absence-of-a-natural-vagina
#15
A Grosse, C Grosse, D Lenggenhager, B Bode, U Camenisch, P Bode
OBJECTIVE: The primary objective of this study was to describe the cytological findings of bowel and (penile) skin-lined neovaginas in patients with gender dysphoria (GD) and individuals with a congenital or acquired absence of a natural vagina. The secondary objective was to correlate the cytological findings with clinical characteristics such as oestrogen replacement therapy (ERT). METHODS: A retrospective review of an institutional pathology archive over a 15-year-period was performed to identify cytological samples of neovaginal vaults...
February 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28214205/synchronous-carcinosarcoma-of-the-uterine-cervix-with-adenoid-basal-carcinoma-and-cervical-intraepithelial-neoplasia-iii-a-case-report-and-literature-review
#16
Yuan Lin, Hanrui Chen, Ziyin Ye, Li Ding, Qinghua Cao, Ling Xue
Carcinosarcoma and adenoid basal carcinoma (ABC) are both rare lesions in uterine cervix. There were only 5 cases of cervical carcinosarcoma combined with ABC and/without cervical intraepithelial neoplasia (CIN) reported in English literature. These limited studies showed that there was a strong association between HPV, carcinosarcoma, ABC and CIN, suggesting a common etiology for these lesions. Here, we present the case of a 65-year-old woman with cervical carcinosarcoma combined with ABC and CIN III. However, HPV-16, 18, 31 and 33 was negative in the cervical carcinosarcoma tissue by in situ hybridization detection...
February 7, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214204/detection-of-occult-endocervical-glandular-dysplasia-in-cervical-conization-specimens-for-squamous-lesions
#17
F Sopracordevole, N Clemente, L Alessandrini, J Di Giuseppe, F Cigolot, M Buttignol, A Ciavattini, V Canzonieri
The aim of this work was to evaluate the incidence of occult cervical glandular intraepithelial neoplasia (CGIN) and adenocarcinoma of the cervix (AC) in women treated with CO2-laser conization for cervical intraepithelial neoplasia (CIN) or squamocellular cervical cancer (SCC). The medical records of all women with a histological diagnosis of squamous lesions of the uterine cervix (persistent CIN1, CIN2, CIN3 and SCC) who were subsequently treated with CO2-laser conization at our institution, during the period from January 1991 to December 2014, were analyzed in a retrospective case series...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28182079/immunocytoexpression-profile-of-proexc-in-smears-interpreted-as-asc-us-asc-h-and-cervical-intraepithelial-lesion
#18
Zeynep Tosuner, İlknur Türkmen, Sema Arici, Cavide Sönmez, Seval Turna, Öykü Onaran
AIMS: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears. SETTINGS AND DESIGN: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28182076/vaginal-infections-of-albanian-women-infected-with-hpv-and-their-impact-in-intraepithelial-cervical-lesions-evidenced-by-pap-test
#19
Elsa S Kone, Avenir D Balili, Piro D Paparisto, Xheladin R Ceka, Elizana D Petrela
BACKGROUND: Cervical cytology is the best single method for large screening of the population in identifying precancerous lesions of the uterine cervix. AIM: To estimate the frequency of human papillomavirus (HPV) positivity in a group of Albanian women, the prevalence of vaginal coinfections, and the relationship of coinfections with HPV, as well as their role in metaplasia or cervical intraepithelial lesions (CIN). MATERIALS AND METHODS: In this retrospective study, 2075 vaginal smears were examined...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28181989/-influence-of-age-in-the-prevalence-of-high-risk-human-papiloma-virus-in-women-with-pre-neoplasic-cervical-lesions-in-navarra-spain
#20
María Rosario Mercado Gutiérrez, Carolina Arean Cuns, María Luisa Gómez Dorronsoro, Irene Paniello Alastruey, Fermin Mallor Giménez, Maria Dolores Lozano Escario, Mercedes Santamaría Martínez
OBJECTIVE: Cervical carcinoma (CC) is the second cause of death among women aged 15 and 44 in Spain. CC is linked to hig-risk human papillomavirus (HR-HPV) infection and its prevalence varies according age and geographical region. The awereness of the latter is essential for public health prevention efforts. The aim was to study the age related in HR-HPV genotypes in cytologies with squamous intraepithelial lesion (SIL). METHODS: From a total of 67,935 ginecologic cytologies over a four-year period, we selected cytologic specimens with SIL...
February 9, 2017: Revista Española de Salud Pública
keyword
keyword
108033
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"