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Cervical intraepithelial lesions

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https://www.readbyqxmd.com/read/29027524/-the-morphological-and-immunohistochemical-characteristics-of-stratified-mucin-producing-intraepithelial-lesion
#1
M V Shamarakova, A V Asaturova, L S Ezhova, M R Dumanovskaya, N M Faizullina, A V Kozachenko
Stratified mucin-producing intraepithelial lesion (SMILE) is a rare premalignant cervical lesion that combines the structural features of cervical intraepithelial neoplasia (CIN) and endocervical adenocarcinoma in situ (AIS). AIM: to analyze archival materials for the detection of SMILE and its subsequent morphological and immunohistochemical characterization. MATERIAL AND METHODS: Cervical cone specimens from 53 women with histologically verified CIN3 were examined...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29021405/high-prevalence-of-high-risk-hpv-genotypes-other-than-16-and-18-in-cervical-cancers-of-cura%C3%A3-ao-implications-for-choice-of-prophylactic-hpv-vaccine
#2
Desiree J Hooi, Birgit I Lissenberg-Witte, Maurits N C de Koning, Herbert M Pinedo, Gemma G Kenter, Chris J L M Meijer, Wim G Quint
BACKGROUND: Curaçao is a Dutch-Caribbean Island located in a high-risk area for cervical cancer.Prior to introduction of a prophylactic human papillomavirus (HPV) vaccine, knowledge of the prevalence of high-risk HPV vaccine genotypes (HPV16, 18, 31, 33, 45, 52 and 58) in cervical (pre)cancer is required. OBJECTIVE: To investigate the prevalence of HPV genotypes in invasive cervical cancers (ICC) and cervical intraepithelial neoplasia (CIN) grade 1, 2 and 3 in Curaçao...
October 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29021084/association-between-epstein-barr-virus-ebv-and-cervical-carcinoma-a-meta-analysis
#3
REVIEW
Marcos Antonio Pereira de Lima, Pedro Januário Nascimento Neto, Lívia Peixoto Moreira Lima, Jucier Gonçalves Júnior, Antonio Gilvan Teixeira Junior, Ilara Parente Pinheiro Teodoro, Heberty Tarso Facundo, Cláudio Gleidiston Lima da Silva, Marcos Venício Alves Lima
Human papillomavirus (HPV) has been implicated as a major factor in cervical carcinogenesis. However, many pieces of evidence gathered over the last two decades suggest Epstein-Barr virus (EBV) plays a secondary role in this process. The purpose of the present meta-analysis was to determine whether the presence of EBV infection increases the risk of cervical carcinoma. Based on 25 articles, the analysis yielded a 33.44% overall pooled prevalence of EBV. The pooled prevalence was higher in patients with carcinoma (43...
October 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28990460/amplification-of-specific-chromosomal-regions-assessed-by-fluorescent-in-situ-hybridization-on-pap-smears-to-be-added-as-screening-tool-for-identifying-women-at-risk-of-progressing-to-cervical-cancer
#4
Pavani Upendram, Shubhi Sahni, Khaliq Mohiuddin, Subhadra Poornima, Bhanumathy Gourishankar, Kiran Kumar Vattam, Pavani Boddala, E Jayashankar, Shakera Mohiuddin, Vasundhara Kamineni, Vasavi Mohan, Jane Houldsworth, Qurratulain Hasan
Cervical carcinoma is a frequent malignancy in developing countries despite being a preventable disease. For the first time, four screening tests were used simultaneously for identifying women with a risk of developing cervical cancer, to help clinicians and policy makers to implement the best strategy for reducing the burden of this disease. Women visiting a hospital in India were enrolled after institutional ethics clearance and informed consent. Visual inspection using acetic acid and Pap smear tests were performed on 2683 women, and 104 had abnormal cytology: atypical squamous cells of undetermined significance (n = 29), low-grade squamous intraepithelial lesion (n = 41), high-grade squamous intraepithelial lesion (n = 17), and squamous cell carcinoma (n = 17)...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28986092/population-based-hpv-vaccination-programmes-are-safe-and-effective-2017-update-and-the-impetus-for-achieving-better-global-coverage
#5
REVIEW
Julia M L Brotherton, Paul N Bloem
Persistent oncogenic human papillomavirus (HPV) is the cause of cervical cancer, as well as cancers of the anus, penis, vulva, vagina and oropharynx. There is good evidence that prophylactic HPV vaccines are immunogenic and effective against targeted-type HPV infections and type-specific genital lesions, including high-grade cervical intraepithelial neoplasia (CIN), when administered prior to HPV infection. There is good evidence that HPV vaccines are safe in population usage, with the most frequent adverse event being injection-site reactions...
September 6, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28985196/inflammatory-stroma-of-lymphoepithelioma-like-carcinoma-of-the-cervix-immunohistochemical-study-of-3-cases-and-review-of-the-literature
#6
Amandine Philippe, Marc Rassy, Ligia Craciun, Céline Naveaux, Karen Willard-Gallo, Denis Larsimont, Isabelle Veys
The aim of this study was to characterize the inflammatory infiltrate of the lymphoepithelioma-like carcinoma, a variant of squamous cell carcinoma clinically associated with a good prognosis. Immunohistochemistry was used to characterize 3 cases of lymphoepithelioma-like carcinoma in the uterine cervix, diagnosed over a period of 3 yr. The patients were between 30 and 50 yr old. Their cervical smears had shown atypical squamous cells of unknown significance or high-grade squamous intraepithelial lesions, and the initial cervical biopsy showed high-grade cervical intraepithelial neoplasia (CIN3) or squamous cell carcinoma...
August 1, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28984338/synchronous-cervical-minimal-deviation-adenocarcinoma-gastric-type-adenocarcinoma-and-lobular-endocervical-glandular-hyperplasia-along-with-stil-in-peutz-jeghers-syndrome-eliciting-oncogenesis-pathways
#7
Azfar Neyaz, Nuzhat Husain, Manish Deodhar, Rohini Khurana, Saumya Shukla, Aditi Arora
We describe an unusual case of a Peutz-Jeghers syndrome associated with a composite synchronous cervical neoplasia comprising precursor "lobular endocervical glandular hyperplasia (LEGH)", "minimal deviation adenocarcinoma (MDA)" and "gastric-type adenocarcinoma (GTA)" along with a serous tubal intraepithelial lesion (STIL) in the right fallopian tube. A 24-year-old woman presented with a white mucoid discharge and bleeding per vaginum for one year. Histopathological evaluation showed MDA & GTA in FIGO grade III with pelvic lymph node metastasis despite a deceptively bland tumour morphology and low Ki-67 index, indicating an aggressive tumour course and poor prognosis...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28983744/human-papillomavirus-genotype-distribution-among-hpv-positive-women-in-sichuan-province-southwest-china
#8
Guo Tao, Gao Yaling, Gao Zhan, Liao Pu, He Miao
In this hospital-based descriptive study, the genotype distribution of human papillomavirus (HPV) among HPV-infected women were investigated in 4,305 gynecological patients in Sichuan province. Females attending gynecology clinics between March 2014 and March 2015 were subjected to HPV screening after giving informed consent. Cervical scrapings were examined by cytopathology and colposcopy-directed biopsies. HPV genotyping was performed on a Luminex 200 system. Seventeen high-risk (HR) genotypes (HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -53, -56, -58, -59, -66, -68, -73, and -82) and seven low-risk (LR) genotypes (HPV-6, -11, -42, -43, -61, -81, and -83) were detected...
October 5, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28974850/difference-between-cryotherapy-and-follow-up-low-grade-squamous-lesion-of-cervix-uteri
#9
Mahira Jahic, Elmir Jahic, Mirsada Mulavdic, Azra Hadzimehmedovic
INTRODUCTION: Cervical cancer can be successfully prevented by effective treatment. AIM: Analyse of success of cryotherapy in LSIL and ASCUS. MATERIALS ET METHODS: In retrospective study between January 2016 to March 2017, 3244 PAP test were analysed. 257 patients who had been diagnosed with LSIL and ASCUS from PAP smear were divided in two groups: women who had HPV positive, colposcopic positive and cytologic finding of LSIL or ASCUS treathed with cryotherapy and women with LSIL, ASCUS and negative colposcopy...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28964706/the-natural-history-of-human-papillomavirus-infection
#10
REVIEW
Silvia de Sanjosé, Maria Brotons, Miguel Angel Pavón
Human papillomavirus (HPV) is a small double-stranded DNA virus that commonly infects humans. The oncogenic characteristics of HPV derive from the oncoproteins E6 and E7 that act inhibiting p53 and pRB tumor suppressors. About 5% of all cancers worldwide are attributable mainly to those known as high-risk, including HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. Infection with HPV is common after sexual initiation, but the majority of HPV infections do not cause symptoms or disease and are cleared within 12-24 months post-infection...
September 6, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28962572/impact-of-hpv-vaccination-health-gains-in-the-italian-female-population
#11
Andrea Marcellusi
BACKGROUND: Human papillomavirus (HPV) is the leading cause of cervical cancer and other malignant and benign neoplastic lesions. HPV vaccination has three potential goals: to prevent transmission, infection, and disease. At present, there are no available data about health consequences of HPV immunization in Italy. The aim of this study is to evaluate the effect of current HPV vaccination strategy in Italy. METHODS: A multistate morbidity-mortality model was developed to estimate the infection process in a theoretical cohort of Italian women...
September 29, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28960293/prevalence-risk-factors-and-pregnancy-outcomes-of-cervical-cell-abnormalities-in-the-puerperium-in-a-hyperendemic-hiv-setting
#12
Hopolang C Maise, Dhayendre Moodley, Motshedisi Sebitloane, Suzanne Maman, Benn Sartorius
OBJECTIVE: To investigate the impact of cervical cell abnormalities detected in the puerperium in association with HIV-1 infection on pregnancy outcomes. METHODS: The present study was a secondary data analysis of pregnancy outcomes, Pap smear results, HIV results, and participant demography from a behavioral intervention randomized controlled trial of 1480 pregnant women aged 18 years or more conducted at a periurban primary health clinic in South Africa during 2008-2010...
September 28, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28953128/incidence-of-anal-dysplasia-in-a-population-of-high-risk-women-observations-at-a-cervical-pathology-unit
#13
María de Los Reyes Oliver-Pérez, Victoria Bravo Violeta, Beatriz Legorburu Alonso, Diana Betancor Pérez, Vicente Bebia Conesa, Jesús S Jiménez López
OBJECTIVES: This study aimed to evaluate the incidence of anal dysplasia in women at high risk of developing those lesions and to assess the relationships between positive anal cytology and different risk factors. MATERIALS AND METHODS: We performed an observational cross-sectional study involving a patient survey and chart review. The study was conducted at the cervical pathology unit at the Hospital Universitario 12 de Octubre, Madrid, Spain, from 2011 to 2015...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28953121/validity-parameters-of-the-human-papillomavirus-detection-test-hybrid-capture-2-with-and-without-cytology-after-laser-destruction-and-large-loop-excision-of-the-transformation-zone-treatment-of-high-grade-cervical-intraepithelial-neoplasia-lesions
#14
Johanna Hansen, Julia Waibel, Sylvia Timme, Gerald Gitsch, Michaela Bossart, Martin K Oehler, Maximilian Klar
OBJECTIVE: The aim of this study was to calculate the validity parameters of the Digene Hybrid Capture 2 (HC2) high-risk human papillomavirus DNA test with and without cytology in the follow-up examinations after laser treatment of the transformation zone or large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia (CIN). METHODS: We performed a standardized follow-up examination in 113 postlaser and 153 post-LLETZ patients in our colposcopy clinic...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28953116/risks-of-cin-2-cin-3-and-cancer-by-cytology-and-human-papillomavirus-status-the-foundation-of-risk-based-cervical-screening-guidelines
#15
Maria Demarco, Thomas S Lorey, Barbara Fetterman, Li C Cheung, Richard S Guido, Nicolas Wentzensen, Walter K Kinney, Nancy E Poitras, Brian Befano, Philip E Castle, Mark Schiffman
OBJECTIVES: The next round of the American Society for Colposcopy and Cervical Pathology (ASCCP)-sponsored cervical cancer screening and management guidelines will recommend clinical actions based on risk, rather than test-based algorithms. This article gives preliminary risk estimates for the screening setting, showing combinations of the 2 most important predictors, human papillomavirus (HPV) status and cytology result. MATERIALS AND METHODS: Among 1,262,713 women aged 25 to 77 years co-tested with HC2 (Qiagen) and cytology at Kaiser Permanente Northern California, we estimated 0-5-year cumulative risk of cervical intraepithelial neoplasia (CIN) 2+, CIN 3+, and cancer for combinations of cytology (negative for intraepithelial lesion or malignancy [NILM], atypical squamous cells of undetermined significance [ASC-US], low-grade squamous intraepithelial lesion [LSIL], atypical squamous cells cannot exclude HSIL [ASC-H], high-grade squamous intraepithelial lesion [HSIL], atypical glandular cells [AGC]) and HPV status...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28952232/novel-techniques-for-morphometric-and-geometrical-analysis-in-squamous-intraepithelial-lesions-on-cervical-smears
#16
Evangelos Tsiambas, Christos Riziotis, Ismini Mavrikos, Elias Armatas, Efstratios Patsouris
No abstract text is available yet for this article.
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28950443/current-cytology-practices-in-korea-a-nationwide-survey-by-the-korean-society-for-cytopathology
#17
Eun Ji Oh, Chan Kwon Jung, Dong-Hoon Kim, Han Kyeom Kim, Wan Seop Kim, So-Young Jin, Hye Kyoung Yoon
Background: Limited data are available on the current status of cytology practices in Korea. This nationwide study presents Korean cytology statistics from 2015. Materials and Methods: A nationwide survey was conducted in 2016 as a part of the mandatory quality-control program by the Korean Society for Cytopathology. The questionnaire was sent to 208 medical institutions performing cytopathologic examinations in Korea. Individual institutions were asked to submit their annual cytology statistical reports and gynecologic cytology-histology correlation data for 2015...
September 27, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28926579/cervical-screening-with-primary-hpv-testing-or-cytology-in-a-population-of-women-in-which-those-aged-33-years-or-younger-had-previously-been-offered-hpv-vaccination-results-of-the-compass-pilot-randomised-trial
#18
RANDOMIZED CONTROLLED TRIAL
Karen Canfell, Michael Caruana, Val Gebski, Jessica Darlington-Brown, Stella Heley, Julia Brotherton, Dorota Gertig, Chloe J Jennett, Annabelle Farnsworth, Jeffrey Tan, C David Wrede, Philip E Castle, Marion Saville
BACKGROUND: Using primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%)...
September 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28923300/influence-of-co-infection-complicated-with-human-papillomavirus-on-cervical-intraepithelial-neoplasia-development-in-patients-with-atypical-squamous-cells-of-undetermined-significance
#19
Hisami Kiseki, Yutaka Tsukahara, Natsumi Tajima, Ayako Tanaka, Aya Horimoto, Naohiko Hashimura
AIM: Human papillomaviruses (HPV) infection is a primary cause of the development of cervical precancerous lesions and cervical cancer. However, the influence of other infections on intraepithelial neoplasia (CIN) development has not been fully elucidated. We evaluated the association between co-infection and CIN development in subjects with atypical squamous cells of undetermined significance (ASCUS). METHOD: Data for ASCUS subjects who had undergone testing for high risk HPV (HR-HPV) and pathological diagnosis were analyzed...
September 8, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#20
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
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