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https://www.readbyqxmd.com/read/27913498/long-term-risk-of-second-malignancy-and-cardiovascular-disease-after-hodgkin-lymphoma-treatment
#1
Flora E van Leeuwen, Andrea K Ng
Long-term survivors of Hodgkin lymphoma (HL) experience several late adverse effects of treatment, with second malignant neoplasms (SMNs) and cardiovascular diseases (CVDs) being the leading causes of death in these patients. Other late effects have also been identified, such as pulmonary dysfunction, endocrinopathies (thyroid dysfunction, infertility), neck muscle atrophy, and persistent fatigue. HL survivors have two- to fourfold increased risks to develop SMNs and CVD compared with the general population...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27911235/robustness-of-the-neurological-prognostic-score-in-brain-metastasis-patients-treated-with-gamma-knife-radiosurgery
#2
Toru Serizawa, Yoshinori Higuchi, Osamu Nagano, Shinji Matsuda, Kyoko Aoyagi, Junichi Ono, Naokatsu Saeki, Yasuo Iwadate, Tatsuo Hirai, Shinya Takemoto, Yuta Shibamoto
OBJECTIVE The neurological prognostic score (NPS) was recently proposed as a means for predicting neurological outcomes, such as the preservation of neurological function and the prevention of neurological death, in brain metastasis patients treated with Gamma Knife radiosurgery (GKRS). NPS consists of 2 groups: Group A patients were expected to have better neurological outcomes, and Group B patients were expected to have poorer outcomes. NPS robustness was tested in various situations. METHODS In total, 3040 patients with brain metastases that were treated with GKRS were analyzed...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27910069/lkb1-as-a-tumor-suppressor-in-uterine-cancer-mouse-models-and-translational-studies
#3
Christopher G Peña, Diego H Castrillón
The LKB1 tumor suppressor was identified in 1998 as the gene mutated in the Peutz-Jeghers Syndrome (PJS), a hereditary cancer predisposition characterized by gastrointestinal polyposis and a high incidence of cancers, particularly carcinomas, at a variety of anatomic sites including the gastrointestinal tract, lung, and female reproductive tract. Women with PJS have a high incidence of carcinomas of the uterine corpus (endometrium) and cervix. The LKB1 gene is also somatically mutated in human cancers arising at these sites...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27902972/unravelling-site-specific-breast-cancer-metastasis-a-microrna-expression-profiling-study
#4
Willemijne A M E Schrijver, Paul J van Diest, Dutch Distant Breast Cancer Metastases Consortium, Cathy B Moelans
Distant metastasis is still the main cause of death from breast cancer. MicroRNAs (miRs) are important regulators of many physiological and pathological processes, including metastasis. Molecular breast cancer subtypes are known to show a site-specific pattern of metastases formation. In this study, we set out to determine the underlying molecular mechanisms of site-specific breast cancer metastasis by microRNA expression profiling.To identify a miR signature for metastatic breast carcinoma that could predict metastatic localization, we compared global miR expression in 23 primary breast cancer specimens with their corresponding multiple distant metastases to ovary (n=9), skin (n=12), lung (n=10), brain (n=4) and gastrointestinal tract (n=10) by miRCURY microRNA expression arrays...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902422/microbiota-dysbiosis-a-new-piece-in-the-understanding-of-carcinogenesis-puzzle
#5
Valeria García-Castillo, Enrique Sanhueza, Eileen McNerney, Sergio A Onate, Apolinaria García
Cancer is defined as an uncontrolled proliferation of malignant cells in a host and it is one of the main causes of death worldwide. Genetic and environmental factors play an important role in its development and the involvement of microbial communities has also recently been recognized. The close relationship that characterizes the colonization of human commensal communities involves health risks particularly when the homeostasis is disturbed. It has been hypothesized that this process may lead to cancer by modulating the inflammatory response of the host, by the production of carcinogenic metabolic products or by the production of toxins which disrupt the cell cycle...
October 21, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27895815/molecular-predictive-markers-in-tumors-of-the-gastrointestinal-tract
#6
REVIEW
Eirini Papadopoulou, Vasiliki Metaxa-Mariatou, Georgios Tsaousis, Nikolaos Tsoulos, Angeliki Tsirigoti, Chrisoula Efstathiadou, Angela Apessos, Konstantinos Agiannitopoulos, Georgia Pepe, Eugenia Bourkoula, George Nasioulas
Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors' genetic profiling using new breakthrough technologies such as next generation sequencing (NGS), leading to the development of targeted therapeutical approaches based upon biomarker-selection...
November 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27888334/capacity-of-lactic-acid-bacteria-in-immunity-enhancement-and-cancer-prevention
#7
REVIEW
Muhammad Shahid Riaz Rajoka, Junling Shi, Jing Zhu, Dongyan Shao, Qingsheng Huang, Hui Yang, Mingliang Jin
Lactic acid bacteria are associated with the human gastrointestinal tract. They are important for maintaining the balance of microflora in the human gut. An increasing number of published research reports in recent years have denoted the importance of producing interferon-gamma and IgA for treatment of disease. These agents can enhance the specific and nonspecific immune systems that are dependent on specific bacterial strains. The mechanisms of these effects were revealed in this investigation, where the cell walls of these bacteria were modulated by the cytokine pathways, while the whole bacterial cell mediated the host cell immune system and regulated the production of tumor necrosis factors and interleukins...
November 26, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27867955/a-new-technique-to-repair-huge-tracheo-gastric-fistula-following-esophagectomy
#8
Francesco Paolo Caronia, Alfonso Fiorelli, Mario Santini, Roberto Alfano, Sergio Castorina
We reported the management of a life-threatening condition as a large tracheo-gastric fistula involved the carina, the left and the right bronchus that complicated Ivor Lewis esophagogastrectomy for esophageal cancer. An urgent right thoracotomy was performed and the tracheal defect was covered with a reversed pedicled pericardial patch reinforced with an intercostal muscle flap. Cervical esophagostomy and a feeding jejunostomy completed the operation. Five months later, the continuity of gastrointestinal tract was restored using a transverse colon...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27867166/the-usefulness-of-using-fiducial-marker-in-proton-therapy-for-locally-advanced-pancreatic-cancer
#9
Masakazu Shimizu, Takahiro Sato, Yoshihide Sawa, Kazuki Terashima, Toshihiro Yanou, Ryoji Ida
BACKGROUND: Though the dosimetric criteria for the gastrointestinal tract were met, late gastrointestinal toxicity was seen in several cases. Therefore, we thought that it was caused by the positional variation of gastrointestine surrounding pancreatic cancer because of peristalsis. METHOD: They were confirmed by CT image regularly. And we evaluated that how much the difference of matching methods for correcting the positional variation influenced dose distribution...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27866909/unsaturated-fatty-acid-synthesis-in-the-gastric-pathogen-helicobacter-pylori-proceeds-via-a-backtracking-mechanism
#10
Hongkai Bi, Lei Zhu, Jia Jia, Liping Zeng, John E Cronan
Helicobacter pylori is a Gram-negative bacterium that inhabits the upper gastrointestinal tract in humans, and the presence of this pathogen in the gut microbiome increases the risk of peptic ulcers and stomach cancer. H. pylori depends on unsaturated fatty acid (UFA) biosynthesis for maintaining membrane structure and function. Although some of the H. pylori enzymes involved in UFA biosynthesis are functionally homologous with the enzymes found in Escherichia coli, we show here that an enzyme HP0773, now annotated as FabX, uses an unprecedented backtracking mechanism to not only dehydrogenate decanoyl-acyl carrier protein (ACP) in a reaction that parallels that of acyl-CoA dehydrogenase, the first enzyme of the fatty acid β-oxidation cycle, but also isomerizes trans-2-decenoyl-ACP to cis-3-decenoyl-ACP, the key UFA synthetic intermediate...
November 16, 2016: Cell Chemical Biology
https://www.readbyqxmd.com/read/27866302/expression-analysis-of-dickkopf-related-protein-3-dkk3-suggests-its-pleiotropic-roles-for-a-secretory-glycoprotein-in-adult-mouse
#11
Junji Inoue, Hirofumi Fujita, Tetsuya Bando, Yoichi Kondo, Hiromi Kumon, Hideyo Ohuchi
Dickkopf-related protein 3 (Dkk3) is the third member of the Dkk gene family and identical to the gene, whose expression was reduced in immortalized cells. Therefore, its another name is reduced expression in immortalized cells. Since the intratumoral introduction of Dkk3 inhibits tumor growth in mouse models of cancers, Dkk3 is likely a tumor suppressor gene. However, the functions of Dkk3 in vivo remain unclear. As the first step to decipher the physiological roles of this gene, we examined the expression pattern of Dkk3 in various tissues from adult mice...
November 19, 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27862680/the-natural-history-of-gastro-esophageal-reflux-disease-a-comprehensive-review
#12
REVIEW
E Savarino, N de Bortoli, C De Cassan, M Della Coletta, O Bartolo, M Furnari, A Ottonello, E Marabotto, G Bodini, V Savarino
Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27859013/needle-tract-seeding-after-percutaneous-biopsy-of-sarcoma-risk-benefit-considerations
#13
REVIEW
David Berger-Richardson, Carol J Swallow
To evaluate histologic subtype and grade, which in turn guide the decision making for multimodality therapy, the workup of suspected sarcoma requires more material than can be obtained from a fine-needle aspiration. Either open or percutaneous core needle biopsy is indicated before a management decision is made. Percutaneous biopsy of a potentially malignant lesion is controversial, given the perceived potential for tumor seeding along the needle tract. However, the evidence that the latter is a significant risk is weak at best...
November 2, 2016: Cancer
https://www.readbyqxmd.com/read/27847663/extramedullary-plasmacytoma-mimicking-pancreatic-cancer-an-unusual-presentation
#14
Daniela Sciancalepore, Sergio Musci, Maria Rosaria Fracella, Grazia D'Alesio, Azzurra Sportelli, Giuseppe Ingravallo, Angelo Vacca, Roberto Ria
Multiple myeloma is a plasma cell tumor that homes to and expands in the bone marrow and that, despite the new available drugs, remains incurable. Extramedullary plasmacytoma is a not frequent manifestation during the natural history of multiple myeloma and is frequently associated with plasma cell bone marrow infiltration. The most common locations for an EMP include the gastrointestinal tract, pleura, testis, skin, peritoneum, liver, endocrine glands, and lymph nodes. Primary involvement of the gallbladder fossa is exceedingly rare...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27847225/mesoporous-silica-nanoparticle-based-enzyme-responsive-system-for-colon-specific-drug-delivery-through-guar-gum-capping
#15
Balmiki Kumar, Senthilguru Kulanthaivel, Animesh Mondal, Smruti Mishra, Biplab Banerjee, Asim Bhaumik, Indranil Banerjee, Supratim Giri
In the global context of increasing colonic diseases, colon specific oral drug delivery systems have shown promise as an effective therapeutic modality. Herein, we developed a mesoporous silica nanoparticle (MSN) based enzyme responsive materials for colon specific drug delivery. We have utilized guar gum, a natural carbohydrate polymer as a capping layer to contain a model drug, such as 5-flurouracil (5FU) within the mesoporous channels of MSN. Analytical characterization including electron microscopy, PXRD, nitrogen sorption, thermogravimetric analysis and FTIR, confirmed that the synthesized MSN with size less than 100nm is of MCM-41type...
October 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27846844/a-rare-case-with-synchronous-gastric-gastrointestinal-stromal-tumor-pancreatic-neuroendocrine-tumor-and-uterine-leiomyoma
#16
Elena Arabadzhieva, Atanas Yonkov, Sasho Bonev, Dimitar Bulanov, Ivanka Taneva, Alexandrina Vlahova, Tihomir Dikov, Violeta Dimitrova
BACKGROUND: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. CASE PRESENTATION: We describe an unusual case with triple tumor localization-a gastric tumor, a formation in the pancreas, which involves the retroperitoneal space, and a uterine leiomyoma...
November 15, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27842662/in-bore-transrectal-mri-guided-prostate-biopsies-are-there-risk-factors-for-complications
#17
Michael Meier-Schroers, Rami Homsi, Guido Kukuk, Karsten Wolter, Georges Decker, Stefan Fischer, Christian Marx, Frederic Carsten Schmeel, Wolfgang Block, Alois Martin Sprinkart, Frank Traeber, Hans Heinz Schild, Winfried Willinek
PURPOSE: To systematically analyze risk factors for complications of in-bore transrectal MRI-guided prostate biopsies (MRGB). MATERIALS AND METHODS: 90 patients, who were scheduled for MRGB were included for this study. Exclusion criteria were coagulation disorders, therapy with anticoagulant drugs, and acute infections of the urinary and the lower gastrointestinal tract. Directly after, one week and one year after the biopsy, we assessed biopsy related complications (e...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27829277/surgical-management-of-biliary-tract-cancers
#18
Mark Fairweather, Vinod P Balachandran, Michael I D'Angelica
Biliary tract cancers (BTC) are aggressive gastrointestinal malignancies that are associated with a poor prognosis. This rare group of tumors includes cancers of the gallbladder, intrahepatic, and extrahepatic biliary tree. Chronic inflammatory processes such as cholelithiasis and chronic bacterial infection of the biliary system remain the most common underlying risk factor although most cases occur sporadically. The majority of patients present with advanced disease accompanied by nonspecific symptoms, making BTCs a therapeutic challenge for clinicians...
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27822767/colorectal-cancer-prognosis-following-obesity-surgery-in-a-population-based-cohort-study
#19
Wenjing Tao, Peter Konings, Mark A Hull, Hans-Olov Adami, Fredrik Mattsson, Jesper Lagergren
BACKGROUND: Obesity surgery involves mechanical and physiological changes of the gastrointestinal tract that might promote colorectal cancer progression. Thus, we hypothesised that obesity surgery is associated with poorer prognosis in patients with colorectal cancer. METHODS: This nationwide population-based cohort study included all patients with an obesity diagnosis who subsequently developed colorectal cancer in Sweden from 1980 to 2012. The exposure was obesity surgery, and the main and secondary outcomes were disease-specific mortality and all-cause mortality, respectively...
November 7, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27818590/preoperative-therapy-in-locally-advanced-esophageal-cancer
#20
REVIEW
Pankaj Kumar Garg, Jyoti Sharma, Ashish Jakhetiya, Aakanksha Goel, Manish Kumar Gaur
Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer (T2 or greater or node positive); however, a high rate of disease recurrence (systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment (preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival...
October 21, 2016: World Journal of Gastroenterology: WJG
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