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https://www.readbyqxmd.com/read/28815519/over-six-decades-of-discovery-and-characterization-of-the-architecture-at-mitochondria-associated-membranes-mams
#1
Maria Sol Herrera-Cruz, Thomas Simmen
The discovery of proteins regulating ER-mitochondria tethering including phosphofurin acidic cluster sorting protein 2 (PACS-2) and mitofusin-2 has pushed contact sites between the endoplasmic reticulum (ER) and mitochondria into the spotlight of cell biology. While the field is developing rapidly and controversies have come and gone multiple times during its history, it is sometimes overlooked that significant research has been done decades ago with the original discovery of these structures in the 1950s and the first characterization of their function (and coining of the term mitochondria-associated membrane, MAM) in 1990...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28781772/enriched-endoplasmic-reticulum-mitochondria-interactions-result-in-mitochondrial-dysfunction-and-apoptosis-in-oocytes-from-obese-mice
#2
Lihong Zhao, Tengfei Lu, Lei Gao, Xiangwei Fu, Shien Zhu, Yunpeng Hou
BACKGROUND: Maternal obesity alters oocytes and subsequent fetal metabolism. An increasing number of studies have shown that the endoplasmic reticulums (ER) or mitochondria have important effects on oocyte quality, but there has been no study of the effect of mitochondria-associated ER membranes (MAMs) on oocyte quality. The present study was designed to assess whether the level of MAM and MAM-related proteins were different in oocytes from obese and control mice. RESULTS: First, oocytes from mice with high-fat-diet (HFD)-induced obesity had higher levels (either greater numbers or a higher proportion for the same numbers) of MAM than oocytes from control mice...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28476937/caught-in-the-act-protein-adaptation-and-the-expanding-roles-of-the-pacs-proteins-in-tissue-homeostasis-and-disease
#3
REVIEW
Gary Thomas, Joseph E Aslan, Laurel Thomas, Pushkar Shinde, Ujwal Shinde, Thomas Simmen
Vertebrate proteins that fulfill multiple and seemingly disparate functions are increasingly recognized as vital solutions to maintaining homeostasis in the face of the complex cell and tissue physiology of higher metazoans. However, the molecular adaptations that underpin this increased functionality remain elusive. In this Commentary, we review the PACS proteins - which first appeared in lower metazoans as protein traffic modulators and evolved in vertebrates to integrate cytoplasmic protein traffic and interorganellar communication with nuclear gene expression - as examples of protein adaptation 'caught in the act'...
June 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28154412/superresolution-imaging-identifies-that-conventional-trafficking-pathways-are-not-essential-for-endoplasmic-reticulum-to-outer-mitochondrial-membrane-protein-transport
#4
Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K Jaiswal, Anamaris M Colberg-Poley
Most nuclear-encoded mitochondrial proteins traffic from the cytosol to mitochondria. Some of these proteins localize at mitochondria-associated membranes (MAM), where mitochondria are closely apposed with the endoplasmic reticulum (ER). We have previously shown that the human cytomegalovirus signal-anchored protein known as viral mitochondria-localized inhibitor of apoptosis (vMIA) traffics from the ER to mitochondria and clusters at the outer mitochondrial membrane (OMM). Here, we have examined the host pathways by which vMIA traffics from the ER to mitochondria and clusters at the OMM...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28122638/of-yeast-mice-and-men-mams-come-in-two-flavors
#5
REVIEW
Maria Sol Herrera-Cruz, Thomas Simmen
The past decade has seen dramatic progress in our understanding of membrane contact sites (MCS). Important examples of these are endoplasmic reticulum (ER)-mitochondria contact sites. ER-mitochondria contacts have originally been discovered in mammalian tissue, where they have been designated as mitochondria-associated membranes (MAMs). It is also in this model system, where the first critical MAM proteins have been identified, including MAM tethering regulators such as phospho-furin acidic cluster sorting protein 2 (PACS-2) and mitofusin-2...
January 25, 2017: Biology Direct
https://www.readbyqxmd.com/read/27831997/pulmonary-arterial-compliance-improves-rapidly-after-left-ventricular-assist-device-implantation
#6
S Carolina Masri, Ryan J Tedford, Monica M Colvin, Peter J Leary, Rebecca Cogswell
Pulmonary artery compliance (PAC) contributes to right ventricular (RV) afterload, is decreased in the setting of increased left ventricular (LV) filling pressures, and may be an important component of World Health Organization (WHO) group II pulmonary hypertension (PH). Left ventricular assist device (LVAD) implantation can rapidly change LV filling, but its relationship with PAC is unknown. Right heart catheterization was performed preoperatively, postoperatively (between 48 and 72 hours), and >30 days post-LVAD implantation in a cohort of 64 patients with end-stage systolic heart failure...
March 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27573309/the-first-picture-archiving-and-communication-system-in-lao-people-s-democratic-republic-changes-in-the-utilization-rate-of-imaging-tests-in-the-first-year-after-implementation
#7
In-Chang Hwang, Kil Won Lee, Sang Soon Park, Siamphone Chanthanoulay, Malouny Sisavanh, Virasack Rajpho, Mijin Kim, Somxay Billamay, Sommanikhone Phangmanixay, Bounleua Oudavong
BACKGROUND: Implementation of the Picture Archiving and Communication System (PACS) is more challenging in developing countries than in developed countries. Given that the first PACS in Lao People's Democratic Republic (PDR) was successfully installed at the Children's Hospital of Lao PDR, we aimed to investigate whether the utilization rate of imaging tests increased after PACS implementation. METHODS: PACS was implemented at the Children's Hospital of Lao PDR in December 2014...
October 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27052940/reproducibility-of-digital-measurements-of-lower-limb-deformity-on-plain-radiographs-and-agreement-with-ct-measurements
#8
G Sorin, G Pasquier, E Drumez, A Arnould, H Migaud, S Putman
INTRODUCTION: Five angles (HKA, HKS, alpha, beta, tibial slope) are used for goniometry in total knee arthroplasty. The reproducibility of the measurement of these angles has been assessed on plain and digitized x-rays, but to our knowledge, this has not been confirmed on x-rays taken on the PACS system and they have not been compared to computed tomography (CT) measurements, the reference for angle measurement. This prospective study aimed to: (1) evaluate the inter- and intrarater reliability of the measurement of these angles on digital x-rays taken on a PACS; (2) determine the agreement of these measurements with those obtained using a CT protocol...
June 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/26943323/pacs-2-mediates-the-atm-and-nf-%C3%AE%C2%BAb-dependent-induction-of-anti-apoptotic-bcl-xl-in-response-to-dna-damage
#9
J Barroso-González, S Auclair, S Luan, L Thomas, K M Atkins, J E Aslan, L L Thomas, J Zhao, Y Zhao, G Thomas
Nuclear factor kappa B (NF-κB) promotes cell survival in response to genotoxic stress by inducing the expression of anti-apoptotic proteins including Bcl-xL, which protects mitochondria from stress-induced mitochondrial outer membrane permeabilization (MOMP). Here we show that the multifunctional sorting protein Pacs-2 (phosphofurin acidic cluster sorting protein-2) is required for Bcl-xL induction following DNA damage in primary mouse thymocytes. Consequently, in response to DNA damage, Pacs-2(-/-) thymocytes exhibit a blunted induction of Bcl-xL, increased MOMP and accelerated apoptosis...
September 1, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/26108729/the-sorting-protein-pacs-2-promotes-erbb-signalling-by-regulating-recycling-of-the-metalloproteinase-adam17
#10
Sarah Louise Dombernowsky, Jacob Samsøe-Petersen, Camilla Hansson Petersen, Rachael Instrell, Anne-Mette Bornhardt Hedegaard, Laurel Thomas, Katelyn Mae Atkins, Sylvain Auclair, Reidar Albrechtsen, Kasper Johansen Mygind, Camilla Fröhlich, Michael Howell, Peter Parker, Gary Thomas, Marie Kveiborg
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are poorly understood. Here, through a functional genome-wide siRNA screen, we identify the sorting protein PACS-2 as a regulator of ADAM17 trafficking and ErbB signalling. PACS-2 loss reduces ADAM17 cell-surface levels and ADAM17-dependent ErbB ligand shedding, without apparent effects on related proteases...
June 25, 2015: Nature Communications
https://www.readbyqxmd.com/read/25966412/electrochemical-generation-of-antimony-volatile-species-stibine-using-gold-and-silver-mercury-amalgamated-cathodes-and-determination-of-sb-by-flame-atomic-absorption-spectrometry
#11
Jessenia Ordoñes, Lenys Fernández, Hugo Romero, Patricio Carrera, José Alvarado
The electrochemical generation of antimony volatile species (stibine) using Au and Ag mercury amalgamated cathodes is described. Compared with some other cathode materials commonly used for electrochemical hydride generation, performance of the amalgamated cathodes is substantially better in the following aspects: higher interference tolerance, higher erosion resistance and longer useful working time. Using the amalgamated cathodes, it could be shown that interferences from major constituents at high concentrations, especially from transition metals, affecting stibine generation are not as significant as they are using other cathode types in regards to sensitivity and useful working time...
August 15, 2015: Talanta
https://www.readbyqxmd.com/read/25815376/endosome-traffic-machinery-meets-the-p53-p21-axis
#12
Jonathan Barroso-González, Gary Thomas
SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK inhibitor p21 (CDKN1A) and induce cell cycle arrest.
2015: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/25514054/determination-and-occurrence-of-phenoxyacetic-acid-herbicides-and-their-transformation-products-in-groundwater-using-ultra-high-performance-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#13
Sarah-Louise McManus, Mary Moloney, Karl G Richards, Catherine E Coxon, Martin Danaher
A sensitive method was developed and validated for ten phenoxyacetic acid herbicides, six of their main transformation products (TPs) and two benzonitrile TPs in groundwater. The parent compounds mecoprop, mecoprop-p, 2,4-D, dicamba, MCPA, triclopyr, fluroxypr, bromoxynil, bentazone, and 2,3,6-trichlorobenzoic acid (TBA) are included and a selection of their main TPs: phenoxyacetic acid (PAC), 2,4,5-trichloro-phenol (TCP), 4-chloro-2-methylphenol (4C2MP), 2,4-dichlorophenol (DCP), 3,5,6-trichloro-2-pyridinol (T2P), and 3,5-dibromo-4-hydroxybenzoic acid (BrAC), as well as the dichlobenil TPs 2,6-dichlorobenzamide (BAM) and 3,5-dichlorobenzoic acid (DBA) which have never before been determined in Irish groundwater...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/25440666/on-line-double-isotope-dilution-laser-ablation-inductively-coupled-plasma-mass-spectrometry-for-the-quantitative-analysis-of-solid-materials
#14
Beatriz Fernández, Pablo Rodríguez-González, J Ignacio García Alonso, Julien Malherbe, Sergio García-Fonseca, Rosario Pereiro, Alfredo Sanz-Medel
We report on the determination of trace elements in solid samples by the combination of on-line double isotope dilution and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The proposed method requires the sequential analysis of the sample and a certified natural abundance standard by on-line IDMS using the same isotopically-enriched spike solution. In this way, the mass fraction of the analyte in the sample can be directly referred to the certified standard so the previous characterization of the spike solution is not required...
December 3, 2014: Analytica Chimica Acta
https://www.readbyqxmd.com/read/25435488/clothing-related-burns-in-new-south-wales-australia-impact-of-legislation-on-a-continuing-problem
#15
Lara A Harvey, Siobhan Connolley, John G Harvey
To combat the risk of nightwear burns a mandatory standard regulating the design, flammability and labelling requirements of children's nightwear was introduced in Australia in 1987. This population-based study examined the trends, characteristics and causes of clothing-related burns to inform a review of the current standard, and to facilitate the development of targeted prevention strategies. Clothing-related burns for 1998-2013 were identified from hospitalisation data for all hospitals in NSW and detailed information regarding circumstance of injury from a burn data registry...
February 2015: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/25419710/chronic-enrichment-of-hepatic-endoplasmic-reticulum-mitochondria-contact-leads-to-mitochondrial-dysfunction-in-obesity
#16
Ana Paula Arruda, Benedicte M Pers, Güneş Parlakgül, Ekin Güney, Karen Inouye, Gökhan S Hotamisligil
Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interactions with each other at sites defined as mitochondria-associated ER membranes (MAMs), which are essential for calcium, lipid and metabolite exchange. Here we show that in the liver, obesity leads to a marked reorganization of MAMs resulting in mitochondrial calcium overload, compromised mitochondrial oxidative capacity and augmented oxidative stress...
December 2014: Nature Medicine
https://www.readbyqxmd.com/read/25244693/perceived-athletic-competence-and-physical-activity-in-children-with-developmental-coordination-disorder-who-are-clinically-referred-and-control-children
#17
Johannes J Noordstar, Ilse Stuive, Hester Herweijer, Lian Holty, Chantal Oudenampsen, Marina M Schoemaker, Heleen A Reinders-Messelink
The relationship between perceived athletic competence (PAC) and physical activity (PA) in children with developmental coordination disorder (DCD) is still unclear. This study investigated differences in PAC and PA between, and within, a group of children with DCD that were clinically referred (n = 31) and a group of control children (n = 38), aged 7-12 years. All children were categorized in four groups: (1) children with DCD/low PAC, (2) children with DCD/normal to high PAC, (3) control children/low PAC, and (4) control children/normal to high PAC...
December 2014: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/25159152/the-multifunctional-sorting-protein-pacs-2-regulates-sirt1-mediated-deacetylation-of-p53-to-modulate-p21-dependent-cell-cycle-arrest
#18
Katelyn M Atkins, Laura L Thomas, Jonathan Barroso-González, Laurel Thomas, Sylvain Auclair, Jun Yin, Hyeog Kang, Jay H Chung, Jimmy D Dikeakos, Gary Thomas
SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here, we demonstrate that the sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate the DNA damage response. PACS-2 knockdown cells failed to efficiently undergo p53-induced cell-cycle arrest in response to DNA damage. Accordingly, p53 acetylation was reduced both in PACS-2 knockdown cells and thymocytes from Pacs-2(-/-) mice, thereby blunting induction of the cyclin-dependent kinase inhibitor p21 (CDKN1A)...
September 11, 2014: Cell Reports
https://www.readbyqxmd.com/read/25025602/polar-metabolites-of-polycyclic-aromatic-compounds-from-fungi-are-potential-soil-and-groundwater-contaminants
#19
Esther S Boll, Anders R Johnsen, Jan H Christensen
This study investigated the sorption to soil of water-soluble metabolites from polycyclic aromatic compounds (PACs). The soil fungus Cunninghamella elegans was used to produce PAC metabolites from two un-substituted PACs (phenanthrene, pyrene), three alkyl-substituted PACs (2-methylnaphthalene, 1-methylphenanthrene, 1-methylpyrene), and one sulfur-containing heterocyclic PAC (dibenzothiophene). Fifty-eight metabolites were tentatively identified; metabolites from the un-substituted PACs were hydroxylated and sulfate conjugated, whereas metabolites from alkyl-substituted PACs were sulfate conjugated and either hydroxylated or oxidized to carboxylic acids at the methyl group...
January 2015: Chemosphere
https://www.readbyqxmd.com/read/24745896/long-term-effect-on-membrane-fouling-in-a-new-membrane-bioreactor-as-a-pretreatment-to-seawater-desalination
#20
Sanghyun Jeong, Scott A Rice, Saravanamuthu Vigneswaran
Submerged membrane adsorption bio-reactors (SMABR) were investigated as a new pretreatment for seawater reverse osmosis (SWRO) desalination. They were tested with different doses of powder activated carbon (PAC) on-site for a long-term. The biofouling on the membrane was assessed in terms of DNA (cells) and polysaccharide distribution. MBR without PAC addition resulted in severe fouling on membrane. When PAC is added in the MBR, PAC could reduce the organic fouling. Hence the biofilm formation on membrane was reduced without any membrane damage...
August 2014: Bioresource Technology
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