Read by QxMD icon Read


In-Chang Hwang, Kil Won Lee, Sang Soon Park, Siamphone Chanthanoulay, Malouny Sisavanh, Virasack Rajpho, Mijin Kim, Somxay Billamay, Sommanikhone Phangmanixay, Bounleua Oudavong
BACKGROUND: Implementation of the Picture Archiving and Communication System (PACS) is more challenging in developing countries than in developed countries. Given that the first PACS in Lao People's Democratic Republic (PDR) was successfully installed at the Children's Hospital of Lao PDR, we aimed to investigate whether the utilization rate of imaging tests increased after PACS implementation. METHODS: PACS was implemented at the Children's Hospital of Lao PDR in December 2014...
October 2016: International Journal of Medical Informatics
G Sorin, G Pasquier, E Drumez, A Arnould, H Migaud, S Putman
INTRODUCTION: Five angles (HKA, HKS, alpha, beta, tibial slope) are used for goniometry in total knee arthroplasty. The reproducibility of the measurement of these angles has been assessed on plain and digitized x-rays, but to our knowledge, this has not been confirmed on x-rays taken on the PACS system and they have not been compared to computed tomography (CT) measurements, the reference for angle measurement. This prospective study aimed to: (1) evaluate the inter- and intrarater reliability of the measurement of these angles on digital x-rays taken on a PACS; (2) determine the agreement of these measurements with those obtained using a CT protocol...
June 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
J Barroso-González, S Auclair, S Luan, L Thomas, K M Atkins, J E Aslan, L L Thomas, J Zhao, Y Zhao, G Thomas
Nuclear factor kappa B (NF-κB) promotes cell survival in response to genotoxic stress by inducing the expression of anti-apoptotic proteins including Bcl-xL, which protects mitochondria from stress-induced mitochondrial outer membrane permeabilization (MOMP). Here we show that the multifunctional sorting protein Pacs-2 (phosphofurin acidic cluster sorting protein-2) is required for Bcl-xL induction following DNA damage in primary mouse thymocytes. Consequently, in response to DNA damage, Pacs-2(-/-) thymocytes exhibit a blunted induction of Bcl-xL, increased MOMP and accelerated apoptosis...
September 1, 2016: Cell Death and Differentiation
Sarah Louise Dombernowsky, Jacob Samsøe-Petersen, Camilla Hansson Petersen, Rachael Instrell, Anne-Mette Bornhardt Hedegaard, Laurel Thomas, Katelyn Mae Atkins, Sylvain Auclair, Reidar Albrechtsen, Kasper Johansen Mygind, Camilla Fröhlich, Michael Howell, Peter Parker, Gary Thomas, Marie Kveiborg
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are poorly understood. Here, through a functional genome-wide siRNA screen, we identify the sorting protein PACS-2 as a regulator of ADAM17 trafficking and ErbB signalling. PACS-2 loss reduces ADAM17 cell-surface levels and ADAM17-dependent ErbB ligand shedding, without apparent effects on related proteases...
2015: Nature Communications
Jessenia Ordoñes, Lenys Fernández, Hugo Romero, Patricio Carrera, José Alvarado
The electrochemical generation of antimony volatile species (stibine) using Au and Ag mercury amalgamated cathodes is described. Compared with some other cathode materials commonly used for electrochemical hydride generation, performance of the amalgamated cathodes is substantially better in the following aspects: higher interference tolerance, higher erosion resistance and longer useful working time. Using the amalgamated cathodes, it could be shown that interferences from major constituents at high concentrations, especially from transition metals, affecting stibine generation are not as significant as they are using other cathode types in regards to sensitivity and useful working time...
August 15, 2015: Talanta
Jonathan Barroso-González, Gary Thomas
SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK inhibitor p21 (CDKN1A) and induce cell cycle arrest.
2015: Molecular & Cellular Oncology
Sarah-Louise McManus, Mary Moloney, Karl G Richards, Catherine E Coxon, Martin Danaher
A sensitive method was developed and validated for ten phenoxyacetic acid herbicides, six of their main transformation products (TPs) and two benzonitrile TPs in groundwater. The parent compounds mecoprop, mecoprop-p, 2,4-D, dicamba, MCPA, triclopyr, fluroxypr, bromoxynil, bentazone, and 2,3,6-trichlorobenzoic acid (TBA) are included and a selection of their main TPs: phenoxyacetic acid (PAC), 2,4,5-trichloro-phenol (TCP), 4-chloro-2-methylphenol (4C2MP), 2,4-dichlorophenol (DCP), 3,5,6-trichloro-2-pyridinol (T2P), and 3,5-dibromo-4-hydroxybenzoic acid (BrAC), as well as the dichlobenil TPs 2,6-dichlorobenzamide (BAM) and 3,5-dichlorobenzoic acid (DBA) which have never before been determined in Irish groundwater...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Beatriz Fernández, Pablo Rodríguez-González, J Ignacio García Alonso, Julien Malherbe, Sergio García-Fonseca, Rosario Pereiro, Alfredo Sanz-Medel
We report on the determination of trace elements in solid samples by the combination of on-line double isotope dilution and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The proposed method requires the sequential analysis of the sample and a certified natural abundance standard by on-line IDMS using the same isotopically-enriched spike solution. In this way, the mass fraction of the analyte in the sample can be directly referred to the certified standard so the previous characterization of the spike solution is not required...
December 3, 2014: Analytica Chimica Acta
Lara A Harvey, Siobhan Connolley, John G Harvey
To combat the risk of nightwear burns a mandatory standard regulating the design, flammability and labelling requirements of children's nightwear was introduced in Australia in 1987. This population-based study examined the trends, characteristics and causes of clothing-related burns to inform a review of the current standard, and to facilitate the development of targeted prevention strategies. Clothing-related burns for 1998-2013 were identified from hospitalisation data for all hospitals in NSW and detailed information regarding circumstance of injury from a burn data registry...
February 2015: Burns: Journal of the International Society for Burn Injuries
Ana Paula Arruda, Benedicte M Pers, Güneş Parlakgül, Ekin Güney, Karen Inouye, Gökhan S Hotamisligil
Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interactions with each other at sites defined as mitochondria-associated ER membranes (MAMs), which are essential for calcium, lipid and metabolite exchange. Here we show that in the liver, obesity leads to a marked reorganization of MAMs resulting in mitochondrial calcium overload, compromised mitochondrial oxidative capacity and augmented oxidative stress...
December 2014: Nature Medicine
Johannes J Noordstar, Ilse Stuive, Hester Herweijer, Lian Holty, Chantal Oudenampsen, Marina M Schoemaker, Heleen A Reinders-Messelink
The relationship between perceived athletic competence (PAC) and physical activity (PA) in children with developmental coordination disorder (DCD) is still unclear. This study investigated differences in PAC and PA between, and within, a group of children with DCD that were clinically referred (n = 31) and a group of control children (n = 38), aged 7-12 years. All children were categorized in four groups: (1) children with DCD/low PAC, (2) children with DCD/normal to high PAC, (3) control children/low PAC, and (4) control children/normal to high PAC...
December 2014: Research in Developmental Disabilities
Katelyn M Atkins, Laura L Thomas, Jonathan Barroso-González, Laurel Thomas, Sylvain Auclair, Jun Yin, Hyeog Kang, Jay H Chung, Jimmy D Dikeakos, Gary Thomas
SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here, we demonstrate that the sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate the DNA damage response. PACS-2 knockdown cells failed to efficiently undergo p53-induced cell-cycle arrest in response to DNA damage. Accordingly, p53 acetylation was reduced both in PACS-2 knockdown cells and thymocytes from Pacs-2(-/-) mice, thereby blunting induction of the cyclin-dependent kinase inhibitor p21 (CDKN1A)...
September 11, 2014: Cell Reports
Esther S Boll, Anders R Johnsen, Jan H Christensen
This study investigated the sorption to soil of water-soluble metabolites from polycyclic aromatic compounds (PACs). The soil fungus Cunninghamella elegans was used to produce PAC metabolites from two un-substituted PACs (phenanthrene, pyrene), three alkyl-substituted PACs (2-methylnaphthalene, 1-methylphenanthrene, 1-methylpyrene), and one sulfur-containing heterocyclic PAC (dibenzothiophene). Fifty-eight metabolites were tentatively identified; metabolites from the un-substituted PACs were hydroxylated and sulfate conjugated, whereas metabolites from alkyl-substituted PACs were sulfate conjugated and either hydroxylated or oxidized to carboxylic acids at the methyl group...
January 2015: Chemosphere
Sanghyun Jeong, Scott A Rice, Saravanamuthu Vigneswaran
Submerged membrane adsorption bio-reactors (SMABR) were investigated as a new pretreatment for seawater reverse osmosis (SWRO) desalination. They were tested with different doses of powder activated carbon (PAC) on-site for a long-term. The biofouling on the membrane was assessed in terms of DNA (cells) and polysaccharide distribution. MBR without PAC addition resulted in severe fouling on membrane. When PAC is added in the MBR, PAC could reduce the organic fouling. Hence the biofilm formation on membrane was reduced without any membrane damage...
August 2014: Bioresource Technology
Maria Eugenia Guicciardi, Nathan W Werneburg, Steven F Bronk, Adrian Franke, Hideo Yagita, Gary Thomas, Gregory J Gores
Lysosomal membrane permeabilization is an essential step in TRAIL-induced apoptosis of liver cancer cell lines. TRAIL-induced lysosomal membrane permeabilization is mediated by the multifunctional sorting protein PACS-2 and repressed by the E3 ligases cIAP-1 and cIAP-2. Despite the opposing roles for PACS-2 and cIAPs in TRAIL-induced apoptosis, an interaction between these proteins has yet to be examined. Herein, we report that cIAP-1 and cIAP-2 confer TRAIL resistance to hepatobiliary cancer cell lines by reducing PACS-2 levels...
2014: PloS One
Beng Leong Lim, Xing Mei Liew, Alicia Vasu, Kim Chai Chan
OBJECTIVES: This study investigated the inter-observer agreement (IOA) between doctors and nurses on triaging adult ED dyspneic patients. METHODS: This was a prospective observational study comparing eight trained ED nurses with doctors. Each patient was assessed by a nurse and two doctors (1 and 2) who decided on four-point Patient Acuity Category (PAC) and triage management steps. The primary outcome was the proportion of resuscitation room escalations from consult...
October 2014: International Emergency Nursing
Wayne L Miller, Diane E Grill, Barry A Borlaug
OBJECTIVES: The purpose of this study was to assess the clinical, functional, and hemodynamic characteristics of passive and mixed pulmonary hypertension (PH), compare outcomes, and contrast conventional and novel hemodynamic partition values in patients with chronic heart failure of reduced left ventricular ejection fraction (HFREF). BACKGROUND: PH in HFREF may develop from left-sided venous congestion (passive PH) or the combination of pulmonary arterial disease and venous congestion (mixed PH)...
August 2013: JACC. Heart Failure
Zheng-Jian Li, Bao-You Shi, Dong-Sheng Wang
The effect of powered activated carbon (PAC) particle size in the range of 10-100 microm on the adsorption of natural organic matter (NOM) in micro-polluted water was investigated, and the adsorption fractionation characteristics in terms of relative molecular mass distribution changes were evaluated. Three PACs with different median particle diameters were obtained through grinding and sieving of a commercial PAC product: PAC-1 (19 microm), PAC-2 (46 microm), and PAC-3 (76 microm). The adsorption results showed that with the decrease of particle size, the adsorption properties (both adsorption capacity and adsorption rate) of PAC for NOM in both simulated and real micro-polluted water were significantly enhanced...
November 2013: Huan Jing Ke Xue= Huanjing Kexue
Miquel Lürling, Frank van Oosterhout
The hypothesis that the combination of the flocculent polyaluminium chloride (PAC) with the lanthanum-modified bentonite Phoslock(®) (Flock & Lock) could sink effectively a water bloom of cyanobacteria and could shift a turbid, cyanobacteria infested lake to a clear water lake was tested in a controlled laboratory experiment and a whole lake experiment. In the laboratory, a relatively low dose of the flocculent PAC (2.2 and 4.4 mg Al l(-1)) was insufficient to sediment positively buoyant cyanobacteria (Microcystis aeruginosa)...
November 1, 2013: Water Research
Jeremy D Volkening, Stephen J Spatz
Herpesvirus replication within host cells results in concatemeric genomic DNA, which is cleaved into unit-length genomes and packaged into the capsid by a complex of proteins. The sites of cleavage have been identified for many herpesviruses, and conserved signaling sequences involved in cleavage and packaging have been characterized. The cleavage/packaging motifs pac-1, pac-2, and DR1 and two distinct groups of telomeric repeat sequences (static TRS and variable TRS) have been identified. By sequencing the termini of the gallid herpesvirus type 2 (GaHV-2) strain CU-2, two different cleavage sites (classical and aberrant) have been identified...
June 2013: Avian Diseases
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"