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lille apathy rating scale

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https://www.readbyqxmd.com/read/27538418/the-prominent-role-of-serotonergic-degeneration-in-apathy-anxiety-and-depression-in-de-novo-parkinson-s-disease
#1
Audrey Maillet, Paul Krack, Eugénie Lhommée, Elise Météreau, Hélène Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amélie Bichon, Pierre Pelissier, Valérie Fraix, Anna Castrioto, Véronique Sgambato-Faure, Emmanuel Broussolle, Léon Tremblay, Stéphane Thobois
SEE SCHRAG AND POLITIS DOI101093/AWW190 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Apathy, which can occur separately or in combination with depression and anxiety, is one of the most frequently encountered neuropsychiatric symptoms in Parkinson's disease. Pathophysiological evidence suggests that parkinsonian apathy is primarily due to a mesolimbic dopaminergic denervation, but the role of the serotonergic alteration has never been examined, despite its well-known involvement in the pathogenesis of depression and anxiety...
September 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27293959/impact-of-sex-on-the-nonmotor-symptoms-and-the-health-related-quality-of-life-in-parkinson-s-disease
#2
Márton Kovács, Attila Makkos, Zsuzsanna Aschermann, József Janszky, Sámuel Komoly, Rita Weintraut, Kázmér Karádi, Norbert Kovács
Background. Female Parkinson's disease (PD) patients seem to experience not only more severe motor complications and postural instability but also more pronounced depression, anxiety, pain, and sleep disturbances. Objective. The aim of the present study was to evaluate the role of sex as a possible independent predictor of HRQoL in PD. Methods. In this cross-sectional study, 621 consecutive patients treated at the University of Pécs were enrolled. Severity of PD symptoms was assessed by MDS-UPDRS, UDysRS, Non-Motor Symptoms Scale, PDSS-2, Hamilton Anxiety Scale, Montgomery-Asberg Depression Rating Scale, Lille Apathy Rating Scale, and Addenbrooke Cognitive Examination...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27151388/apathy-in-patients-with-parkinson-s-disease-following-deep-brain-stimulation-of-the-subthalamic-nucleus
#3
Isabel Hindle Fisher, Hardev S Pall, Rosalind D Mitchell, Jamilla Kausar, Andrea E Cavanna
OBJECTIVE: Apathy has been reported as a possible adverse effect of deep brain stimulation of the subthalamic nucleus (STN-DBS). We investigated the prevalence and severity of apathy in 22 patients with Parkinson's disease (PD) who underwent STN-DBS, as well as the effects of apathy on quality of life (QOL). METHODS: All patients were assessed with the Lille Apathy Rating Scale (LARS), the Apathy Scale (AS), and the Parkinson's Disease Questionnaire and were compared to a control group of 38 patients on pharmacotherapy alone...
June 2016: CNS Spectrums
https://www.readbyqxmd.com/read/26889636/lille-apathy-rating-scale-and-mds-updrs-for-screening-apathy-in-parkinson-s-disease
#4
Rita Weintraut, Kázmér Karádi, Tivadar Lucza, Márton Kovács, Attila Makkos, József Janszky, Norbert Kovács
BACKGROUND: Apathy is a syndrome characterized primarily by lack of motivation which may be associated with cognitive, affective and behavioral changes. Although the Lille Apathy Scale (LARS) has been extensively utilized in PD for detecting apathy and testing the effectiveness of specific therapeutic interventions, the highly variable cut-off values (between -11 and -22 points) ensures the applicability of the LARS degree of difficulty as a superb screening tool. OBJECTIVE: The aim of this study is to determine more reliable threshold values based on the neuropsychiatric status of patients...
2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/26834026/working-memory-deficit-as-a-risk-factor-for-severe-apathy-in-schizophrenia-a-1-year-longitudinal-study
#5
Stéphane Raffard, Laure-Anne Gutierrez, Hanan Yazbek, Aurore Larue, Jean-Philippe Boulenger, Christophe Lançon, Michel Benoit, Catherine Faget, Joanna Norton, Delphine Capdevielle
Apathy, described as impaired motivation and goal-directed behavior, is a common yet often overlooked multidimensional psychopathological state in schizophrenia. Its underlying cognitive processes remain largely unexplored. Data was drawn from a longitudinal hospital study of patients with a DSM-IV diagnosis of schizophrenia; 137 (82.5%) participated at the 1-month follow-up and 81 (59.1%) at the 1-year follow-up. Apathy was assessed with the Lille Apathy Rating Scale, validated in French and in schizophrenia...
May 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/26803583/validation-of-the-lille-s-apathy-rating-scale-in-very-mild-to-moderate-dementia
#6
Marta Fernández-Matarrubia, Jordi A Matías-Guiu, Teresa Moreno-Ramos, María Valles-Salgado, Alberto Marcos-Dolado, Rocío García-Ramos, Jorge Matías-Guiu
OBJECTIVE: Apathy is one of the most common and disabling syndromes of dementia and presents at all stages of the disease. Comprehensive and structured methods to assess apathy in dementia are still needed. Lille's Apathy Rating Scale (LARS) has shown good psychometric properties for apathy evaluation in Parkinson disease but has not been validated in dementia. The aim of this study was to validate the LARS in a cohort of patients with very mild to moderate dementia. METHODS: 101 patients with cognitive impairment (Clinical Dementia Rating ≤ 2) and 50 healthy subjects were recruited...
July 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26695691/accuracy-of-screening-instruments-for-detection-of-neuropsychiatric-syndromes-in-parkinson-s-disease
#7
REVIEW
Pablo Martinez-Martin, Albert F G Leentjens, Jesus de Pedro-Cuesta, Kallol Ray Chaudhuri, Anette E Schrag, Daniel Weintraub
Parkinson's disease includes neuropsychiatric manifestations, such as depression, anxiety, apathy, psychosis, and impulse control disorders, which often are unreported by patients and caregivers or undetected by doctors. Given their substantial impact on patients and caregivers as well as the existence of effective therapies for some of these disorders, screening for neuropsychiatric symptoms is important. Instruments for screening have a particular methodology for validation, and their performance is expressed in terms of accuracy compared with formal diagnostic criteria...
March 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/26312893/mechanisms-underlying-apathy-in-parkinson-s-disease
#8
Kinan Muhammed, Sanjay Manohar, Masud Husain
BACKGROUND: Apathy is a common syndrome observed in many neurological conditions, including in up to 70% of patients with Parkinson's disease. Mechanisms underlying apathy are poorly understood and clinically we lack robust, objective detection methods. We aimed to address this using novel objective measures of motivation and reward sensitivity in relation to apathy in patients with Parkinson's disease. METHODS: Saccadic velocity and pupil modulation by reward were used as objective metrics of motivation in patients with Parkinson's disease...
February 26, 2015: Lancet
https://www.readbyqxmd.com/read/25967086/dopamine-enhances-willingness-to-exert-effort-for-reward-in-parkinson-s-disease
#9
Trevor T-J Chong, Valerie Bonnelle, Sanjay Manohar, Kai-Riin Veromann, Kinan Muhammed, George K Tofaris, Michele Hu, Masud Husain
Parkinson's disease (PD) is traditionally conceptualised as a disorder of movement, but recent data suggest that motivational deficits may be more pervasive than previously thought. Here, we ask whether subclinical deficits in incentivised decision-making are present in PD and, if so, whether dopaminergic therapy ameliorates such deficits. We devised a novel paradigm in which participants decided whether they were willing to squeeze a hand-held dynamometer at varying levels of force for different magnitudes of reward...
August 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/25809278/international-validation-of-a-behavioral-scale-in-parkinson-s-disease-without-dementia
#10
MULTICENTER STUDY
Isabelle Rieu, Pablo Martinez-Martin, Bruno Pereira, Ingrid De Chazeron, Leo Verhagen Metman, Marjan Jahanshahi, Claire Ardouin, Isabelle Chéreau, Christine Brefel-Courbon, Fabienne Ory-Magne, Helene Klinger, Fleur Peyrol, Michael Schupbach, Kathy Dujardin, François Tison, Jean Luc Houeto, Paul Krack, Franck Durif
The "Ardouin Scale of Behavior in Parkinson's Disease" is a new instrument specifically designed for assessing mood and behavior with a view to quantifying changes related to Parkinson's disease, to dopaminergic medication, and to non-motor fluctuations. This study was aimed at analyzing the psychometric attributes of this scale in patients with Parkinson's disease without dementia. In addition to this scale, the following measures were applied: the Unified Parkinson's Disease Rating Scale, the Montgomery and Asberg Depression Rating Scale, the Lille Apathy Rating Scale, the Bech and Rafaelsen Mania Scale, the Positive and Negative Syndrome Scale, the MacElroy Criteria, the Patrick Carnes criteria, the Hospital Anxiety and Depression Scale, and the Mini-International Neuropsychiatric Interview...
April 15, 2015: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/25649495/international-validation-of-a-behavioral-scale-in-parkinson-s-disease-without-dementia
#11
Isabelle Rieu, Pablo Martinez-Martin, Bruno Pereira, Ingrid De Chazeron, Leo Verhagen Metman, Marjan Jahanshahi, Claire Ardouin, Isabelle Chéreau, Christine Brefel-Courbon, Fabienne Ory-Magne, Helene Klinger, Fleur Peyrol, Michael Schupbach, Kathy Dujardin, François Tison, Jean Luc Houeto, Paul Krack, Franck Durif
The "Ardouin Scale of Behavior in Parkinson's Disease" is a new instrument specifically designed for assessing mood and behavior with a view to quantifying changes related to Parkinson's disease, to dopaminergic medication, and to non-motor fluctuations. This study was aimed at analyzing the psychometric attributes of this scale in patients with Parkinson's disease without dementia. In addition to this scale, the following measures were applied: the Unified Parkinson's Disease Rating Scale, the Montgomery and Asberg Depression Rating Scale, the Lille Apathy Rating Scale, the Bech and Rafaelsen Mania Scale, the Positive and Negative Syndrome Scale, the MacElroy Criteria, the Patrick Carnes criteria, the Hospital Anxiety and Depression Scale, and the Mini-International Neuropsychiatric Interview...
August 2, 2007: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/25545189/circadian-sleep-wake-rhythm-abnormalities-as-a-risk-factor-of-a-poststroke-apathy
#12
Charlotte Cosin, Igor Sibon, Mathilde Poli, Michèle Allard, Sabrina Debruxelles, Pauline Renou, François Rouanet, Willy Mayo
BACKGROUND: Poststroke apathy affects 19-55% of patients following stroke and has a negative impact on functional recovery, general health, and quality of life, as well as being a source of significant burden for caregivers. AIMS: A major clinical issue is the delayed diagnosis of poststroke apathy, and so the aim of our study is to evaluate the relationship between early poststroke alterations of circadian rhythms of sleep/wake cycles and the occurrence of poststroke apathy...
July 2015: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/25379547/validation-of-a-spanish-version-of-the-lille-apathy-rating-scale-for-parkinson-s-disease
#13
Rocio García-Ramos, Clara Villanueva Iza, María José Catalán, Abilio Reig-Ferrer, Jorge Matías-Guíu
INTRODUCTION: To date, no rating scales for detecting apathy in Parkinson's disease (PD) patients have been validated in Spanish. For this reason, the aim of this study was to validate a Spanish version of Lille apathy rating scale (LARS) in a cohort of PD patients from Spain. PARTICIPANTS AND METHODS: 130 PD patients and 70 healthy controls were recruited to participate in the study. Apathy was measured using the Spanish version of LARS and the neuropsychiatric inventory (NPI)...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/25355282/a-systematic-review-of-the-validity-and-reliability-of-apathy-scales-in-neurodegenerative-conditions
#14
REVIEW
Ratko Radakovic, Catherine Harley, Sharon Abrahams, John M Starr
BACKGROUND: There are several scales used to detect apathy in disease populations. Since apathy is a prevalent symptom in many neurodegenerative diseases, this is an especially important context in which to identify and compare scales. AIMS: To provide an overview of apathy scales validated in generic and specific neurodegenerative disease populations, compare validation studies' methodological quality and the psychometric properties of the validated apathy scales...
June 2015: International Psychogeriatrics
https://www.readbyqxmd.com/read/25049450/apathy-and-emotion-based-decision-making-in-amnesic-mild-cognitive-impairment-and-alzheimer-s-disease
#15
Sophie Bayard, Jean-Pierre Jacus, Stéphane Raffard, Marie-Christine Gely-Nargeot
BACKGROUND: Apathy and reduced emotion-based decision-making are two behavioral modifications independently described in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). OBJECTIVES: The aims of this study were to investigate decision-making based on emotional feedback processing in AD and aMCI and to study the impact of reduced decision-making performances on apathy. METHODS: We recruited 20 patients with AD, 20 participants with aMCI, and 20 healthy controls...
2014: Behavioural Neurology
https://www.readbyqxmd.com/read/24875172/the-lille-apathy-rating-scale-lars-exploring-its-psychometric-properties-in-schizophrenia
#16
Hanan Yazbek, Joanna Norton, Delphine Capdevielle, Aurore Larue, Jean-Philippe Boulenger, Marie-Christine Gély-Nargeot, Stéphane Raffard
BACKGROUND: Apathy in schizophrenia patients is linked to marked functional impairments and can be defined as a quantitative reduction of voluntary, goal-directed behaviors. If there are now convincing arguments to consider apathy as a multidimensional psychopathological state (cognitive, emotional, and behavioral), there is a lack of validated and standardized instruments for detecting apathy and assessing its multidimensional aspects in schizophrenia. The Lille Apathy Rating Scale (LARS) is a semi-structured interview, yielding a global score and composite subscores for the different domains of apathy and has been validated in several different contexts but not in schizophrenia patients...
August 2014: Schizophrenia Research
https://www.readbyqxmd.com/read/24747776/characterization-of-reward-and-effort-mechanisms-in-apathy
#17
REVIEW
Valerie Bonnelle, Kai-Riin Veromann, Stephanie Burnett Heyes, Elena Lo Sterzo, Sanjay Manohar, Masud Husain
Apathy is a common but poorly understood condition with a wide societal impact observed in several brain disorders as well as, to some extent, in the normal population. Hence the need for better characterization of the underlying mechanisms. The processes by which individuals decide to attribute physical effort to obtain rewards might be particularly relevant to relate to apathy traits. Here, we designed two paradigms to assess individual differences in physical effort production and effort-based decision-making and their relation to apathy in healthy people...
February 2015: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/24647244/-impact-of-dysexecutive-syndrome-on-autonomy-in-early-alzheimer-s-disease-and-mild-cognitive-impairment
#18
Jean-Pierre Jacus, Marie-Christine Gély-Nargeot
BACKGROUND: Early impairment of the cognitive and behavioral executive processes are found in Mild Cognitive Impairment (MCI) as well as in Alzheimer's disease (AD). These processes are strongly linked to autonomy in daily living because they are involved in our adaptation to many new situations. OBJECTIVES AND METHODS: To evaluate the executive processes and their links with autonomy, we compared 20 control subjects to 20 patients with MCI, and 20 patients with early AD...
March 2014: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/24477491/unusual-features-of-creutzfeldt-jakob-disease-followed-up-in-a-memory-clinic
#19
Agnès Jacquin, Vincent Deramecourt, Serge Bakchine, Claude-Alain Maurage, Florence Pasquier
Sporadic Creutzfeldt-Jakob disease (sCJD) generally manifests itself by cognitive or rapidly progressive motor symptoms. An atypical onset or an unusual evolution may delay the diagnosis. Among patients with a confirmed diagnosis of sCJD following a post-mortem neuropathological examination at the Neuropathology Centre of Lille, France, those who had presented with atypical cognitive disorders at onset were included in the study. Four patients were included. The first patient (64-years-old) presented early language disorders, later accompanied by apathy and behavioral disorders...
April 2014: Journal of Neurology
https://www.readbyqxmd.com/read/24218528/rivastigmine-in-apathetic-but-dementia-and-depression-free-patients-with-parkinson-s-disease-a-double-blind-placebo-controlled-randomised-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
David Devos, Caroline Moreau, David Maltête, Romain Lefaucheur, Alexandre Kreisler, Alexandre Eusebio, Gilles Defer, Thavarak Ouk, Jean-Philippe Azulay, Pierre Krystkowiak, Tatiana Witjas, Marie Delliaux, Alain Destée, Alain Duhamel, Régis Bordet, Luc Defebvre, Kathy Dujardin
BACKGROUND: Even with optimal dopaminergic treatments, many patients with Parkinson's disease (PD) are frequently incapacitated by apathy prior to the development of dementia. We sought to establish whether rivastigmine's ability to inhibit acetyl- and butyrylcholinesterases could relieve the symptoms of apathy in dementia-free, non-depressed patients with advanced PD. METHODS: We performed a multicentre, parallel, double-blind, placebo-controlled, randomised clinical trial (Protocol ID: 2008-002578-36; clinicaltrials...
June 2014: Journal of Neurology, Neurosurgery, and Psychiatry
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