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Gender specific therapies and disorders

Dawn E Sugarman, Sara B Wigderson, Brittany R Iles, Julia S Kaufman, Garrett M Fitzmaurice, E Yvette Hilario, Michael S Robbins, Shelly F Greenfield
BACKGROUND AND OBJECTIVES: A Stage II, two-site randomized clinical trial compared the manualized, single-gender Women's Recovery Group (WRG) to mixed-gender group therapy (Group Drug Counseling; GDC) and demonstrated efficacy. Enhanced affiliation and support in the WRG is a hypothesized mechanism of efficacy. This study sought to extend results of the previous small Stage I trial that showed the rate of supportive affiliative statements occurred more frequently in WRG than GDC. METHODS: Participants (N = 158; 100 women, 58 men) were 18 years or older, substance dependent, and had used substances within the past 60 days...
October 2016: American Journal on Addictions
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
Kun Li, Miho Nakajima, Ines Ibañez-Tallon, Nathaniel Heintz
The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female sociosexual behavior. Here, we show that, in male mice, OxtrINs regulate anxiety-related behaviors. We demonstrate that corticotropin-releasing-hormone-binding protein (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs. Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyramidal cell activity of male, but not female, mice, thus producing an anxiolytic effect...
September 22, 2016: Cell
José Luis Albasanz, Soraya Santana, Fernando Guzman-Sanchez, David Agustín León, Javier S Burgos, Mairena Martin
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer's disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from AD patients. Metabotropic glutamate 5 (mGlu5) receptors are G-protein coupled receptors proposed as potential targets for therapy of different neurodegenerative disorders. Thus, MPEP (2-Methyl-6-(phenylethynyl)pyridine hydrochloride), a selective non-competitive mGlu5 receptors antagonist, has been suggested for pharmacological treatment of AD...
September 16, 2016: ACS Chemical Neuroscience
Daniel Oder, Peter Nordbeck, Christoph Wanner
Anderson-Fabry disease is a potentially life-threatening hereditary lysosomal storage disorder taking origin in over 1,000 known pathogenic mutations in the alpha-galactosidase A encoding gene. Over the past 15 years, intravenous replacement therapy of the deficient alpha agalsidase A enzyme has been well-established retarding the progression of a multisystemic disease and organ involvement. Despite this innovative treatment approach, premature deaths still do occur. The response to enzyme replacement therapy (ERT) varies considerably and appears to depend on gender, genotype (classic or later onset/non-classic), stage of disease or age and agalsidase inhibition by anti-agalsidase antibodies...
2016: Nephron
Sven C Mueller, Lionel Landré, Katrien Wierckx, Guy T'Sjoen
BACKGROUND: To date, research findings are inconsistent about whether neuroanatomy in transgender persons resembles that of their natal sex or their gender identity. Moreover, few studies have examined the effects of long-term, cross-sex hormonal treatment on neuroanatomy in this cohort. The purpose of the present study was to examine neuroanatomical differences in transgender persons after prolonged cross-sex hormone therapy. METHODS: Eighteen transgender men (female-to-male), 17 transgender women (male-to-female), 30 non-transgender men (natal men), and 27 non-transgender women (natal women) completed a high-resolution structural MRI scan at 3Tesla...
August 5, 2016: Neuroendocrinology
Anna Maria Berghella, Ida Contasta, Roberto Lattanzio, Giancarlo Di Gregorio, Irma Campitelli, Silvino Marino, Luigi Liborio Liberatore, Luca Navarra, Giampaolo Caterino, Antonio Mongelli, Vincenzo Vittorini, Matteo Basta, Mauro Domenicucci, Nunzia Antonucci, Tiziana Del Beato, Enzo Secinaro, Fabiana Ciccone, Patrizia Pellegrini
The definition of personalized treatments in tumor disease could lead to an improvement of the therapeutic success rate. Therefore, biomarkers are urgently required in order to select the patients that could benefit from adjuvant therapies in the initial phase of the disease and to better define and treat the clinical/therapeutic subgroups in the advanced pathological phases. Disregulation of cytokine physiological network is directly involved in the genesis and progression of tumors. Cytokines are of central importance in the regulation of immune system, but they are rarely released singly: each cytokine is able to induce the production of many others factors leading to a network in which they cooperate with other cell regulators such as hormones and neuropeptides...
June 30, 2016: Current Drug Targets
Gemma Pastor-Cerezuela, Maria-Inmaculada Fernández-Andrés, Mireia Feo-Álvarez, Francisco González-Sala
We administered a semantic verbal fluency (SVF) task to two groups of children (age range from 5 to 8): 47 diagnosed with Autism Spectrum Disorder (ASD Group) and 53 with typical development (Comparison Group), matched on gender, chronological age, and non-verbal IQ. Four specific indexes were calculated from the SVF task, reflecting the different underlying cognitive strategies used: clustering (component of generativity and lexical-semantic access), and switching (executive component, cognitive flexibility)...
2016: Frontiers in Psychology
Gerd Glaeske
Over the past few years, perceptible changes - both fundamental and specific - have taken place in pharmaceutical care for men. While the most striking difference persists, namely that between somatic drug therapies for men and drugs for the treatment of psychological disorders and diseases, the large discrepancies that long existed between the quantities prescribed for men and women have meanwhile not only evened out, but men are even prescribed larger quantities than women if they undergo drug therapy. An analysis of the drugs prescribed particularly for men revealed that they are primarily prescribed for the treatment of cardiovascular diseases (hypertension and cardiac insufficiency) and metabolic disorders (diabetes, gout), especially in elderly patients...
August 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
V Dinkelacker
INTRODUCTION: Drug-resistant epilepsy is a debilitating condition that warrants new therapeutic options. The last two decades have seen a growing interest in the relationship between epilepsy and obstructive sleep apnea syndrome (OSAS), which could ultimately yield non-pharmaceutical treatment strategies. Based on a Medline search of the literature, this review develops lines of evidence for a clinically significant role of OSAS in refractory epilepsy. STATE OF THE ART: OSAS is a primary sleep disorder that could presumably lower the seizure threshold via mechanisms such as sleep fragmentation, oxygen desaturation and chronic sleep deprivation...
June 2016: Revue Neurologique
Nagwa Meguid, Mona Anwar, Safaa Zaki, Wafaa Kandeel, Nihad Ahmed, Ihab Tewfik
AIM: In the hope to assist in tailoring individualized nutritional therapy, this study aimed to assess the nutritional status of autistic children. MATERIAL AND METHODS: This cross-sectional study included 80 autistic children, divided into two groups: group 1 (aged 3- 5 years) and group 2 (aged 6-9 years). Diagnosis was performed based on the criteria for autistic disorder as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Autism Diagnostic Interview Revised and Autism Rating Scale...
June 15, 2015: Open Access Macedonian Journal of Medical Sciences
Doodipala Samba Reddy
Catamenial epilepsy is a type of refractory epilepsy characterized by seizure clusters around perimenstrual or periovulatory period. The pathophysiology of catamenial epilepsy still remains unclear, yet there are few animal models to study this gender-specific disorder. The pathophysiology of perimenstrual catamenial epilepsy involves the withdrawal of the progesterone-derived GABAergic neurosteroids due to the decline in progesterone level at the time of menstruation. These manifestations can be faithfully reproduced in rodents by specific neuroendocrine manipulations...
2016: Frontiers in Cellular Neuroscience
Zilla H Hussain, Kelly Everhart, Brian E Lacy
Constipation is a highly prevalent disorder that affects people regardless of age, race, gender, or socioeconomic status. For many patients, constipation is a chronic condition that reduces quality of life. Chronic constipation also imposes a significant economic burden on the health care system. The treatment of constipation remains problematic for both patients and providers for a variety of reasons, including a lack of specificity of symptoms, an inconsistent relationship between underlying pathophysiology and symptom generation, and different and unpredictable patient responses to medications...
February 2015: Gastroenterology & Hepatology
Maria Dorobantu, Sebastian Onciul, Oana Florentina Tautu, Edina Cenko
BACKGROUND: Ischemic heart disease (IHD) is the most important cause of mortality worldwide. Although the awareness of cardiovascular risk factors and IHD in women has increased over the last decades, mortality rates are still higher in women than in men. Among traditional cardiovascular risk factors, hypertension is associated with a greater risk for IHD in women as compared to men. METHODS: In this review, discuss gender differences in epidemiology and pathophysiology of hypertension and its impact on the incidence and outcomes of IHD in women...
2016: Current Pharmaceutical Design
C Ibrahim, R Haddad, S Richa
INTRODUCTION: The question of whether gender dysphoria is associated with psychiatric comorbidity has been addressed in several studies. Several cohort studies have shown that psychiatric comorbidity is one of the main features of poor prognosis following sex change therapy. Gender dysphoria is rare, with an estimated prevalence of 0.001% to 0.002% globally. The literature shows a high prevalence of psychiatric comorbidities in people with gender dysphoria, and that they are more common in male to female transsexuals...
March 23, 2016: L'Encéphale
J Bonigen, A Phan, S Hadj-Rabia, F Boralévi, A-C Bursztejn, C Bodemer, M Ferneiny, A-L Souillet, C Chiavérini, E Bourrat, J Miquel, P Vabres, S Barbarot, D Bessis, C Eschard, J Mazereeuw-Hautier, M Piram, P Plantin, C Abasq, A Lasek-Duriez, A Maruani, A Beauchet, E Mahé
BACKGROUND: The prevalence of childhood psoriasis is estimated at between 0.4% and 0.7%. Clinical aspects of the diseases depend on age. The aim of this study was to investigate the clinical aspects of psoriasis according to age and sex. PATIENTS AND METHODS: A cross-sectional, multicentre study of children with psoriasis was performed by investigators belonging to the Research Group of the French Society of Paediatric Dermatology. The study was conducted from April 2012 to March 2013...
May 2016: Annales de Dermatologie et de Vénéréologie
Rebeca Antunes Beraldo, Gabriela Cristina Meliscki, Bruna Ramos Silva, Anderson Marliere Navarro, Valdes Roberto Bollela, André Schmidt, Maria Cristina Foss-Freitas
BACKGROUND: Highly active antiretroviral therapy (HAART) can cause side effects in HIV patients, as the metabolic syndrome. Early identification of risk for development of cardiovascular diseases using available reliable and practical methods is fundamental. On this basis, the aim of this study was to compare the effectiveness of anthropometric indicators to identify metabolic syndrome in HIV patients on HAART. METHODS: It is a cross-sectional study. A number of 280 stable HIV patients were studied...
2016: PloS One
Pasquale Santangeli, Luigi Di Biase, Eloisa Basile, Amin Al-Ahmad, Andrea Natale
The number of invasive electrophysiological procedures is steadily increasing in Western countries, as the age of the population increases and technologies advance. In recent years, gender-related differences in cardiac rhythm disorders have been increasingly appreciated, which can potentially have a great impact on the outcomes of invasive electrophysiological procedures. Among supraventricular arrhythmias, women have a higher incidence of atrioventricular nodal re-entrant tachycardia and a significantly lower incidence of atrioventricular re-entrant tachycardia compared with males, and present to ablation procedures later and after having failed more antiarrhythmic drugs...
April 2013: Arrhythmia & Electrophysiology Review
Marc De Bodt, Leen Van den Steen, Fons Mertens, Jan Raes, Lieve Van Bel, Louis Heylen, Jos Pattyn, Frans Gordts, Paul van de Heyning
OBJECTIVE: The aim of this study was to define patient characteristics of a dysphonic population in terms of voice disorder, gender, age, and subjective and objective vocal parameters and to explore the relevant characteristics of the most frequent groups of voice disorders. PATIENTS AND METHODS: Patient records from 4,447 subjects referred for voice assessment and/or voice therapy were analyzed. RESULTS: Significantly more cases of dysphonia were structural as compared to nonstructural...
2015: Folia Phoniatrica et Logopaedica
Gotthard G Tribl, Mateus C Trindade, Thais Bittencourt, Geraldo Lorenzi-Filho, Rosana Cardoso Alves, Daniel Ciampi de Andrade, Erich T Fonoff, Edson Bor-Seng-Shu, Alexandre A Machado, Carlos H Schenck, Manoel J Teixeira, Egberto R Barbosa
OBJECTIVE: Quantitative data are reported on rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of predominantly neurological Wilson's disease (WD). METHODS: A total of 41 patients with WD and 41 healthy, age- and gender-matched controls were studied by conducting face-to-face interviews, neurological and clinical examinations, laboratory tests, and WD- and RBD-specific scales. Video-polysomnography and quantification of REM sleep without atonia (RWA) were conducted in 35 patients and 41 controls...
January 2016: Sleep Medicine
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