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Gender specific therapies and disorders

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https://www.readbyqxmd.com/read/28193237/evaluation-of-quality-of-life-in-adults-with-neurofibromatosis-1-nf1-using-the-impact-of-nf1-on-quality-of-life-inf1-qol-questionnaire
#1
Rosalie E Ferner, Mary Thomas, Gemma Mercer, Victoria Williams, Guy D Leschziner, Shazia K Afridi, John F Golding
BACKGROUND: Neurofibromatosis 1 (NF1) is an inherited, multi-system, tumour suppressor disorder with variable complications that cause psychological distress and social isolation. The study aim was to develop and validate a disease-specific questionnaire to measure quality of life (QOL) in NF1 that is suitable both as an assessment tool in clinical practice and in clinical trials of novel therapy. METHODS: The Impact of NF1 on Quality of Life (INF1-QOL) questionnaire was developed by a literature search for common terms, focus group (n = 6), semi-structured interviews (n = 21), initial drafts (n =50) and final 14 item questionnaire (n = 50)...
February 14, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28170001/the-mcp-4-mcp-1-ratio-in-plasma-is-a-candidate-circadian-biomarker-for-chronic-post-traumatic-stress-disorder
#2
C Dalgard, O Eidelman, C Jozwik, C H Olsen, M Srivastava, R Biswas, Y Eudy, S W Rothwell, G P Mueller, P Yuan, W C Drevets, H K Manji, M Vythlingam, D S Charney, A Neumeister, R J Ursano, D M Jacobowitz, H B Pollard, O Bonne
Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can have a waxing and waning course of symptoms. It has been hypothesized that proinflammatory cytokines and chemokines in the cerebrospinal fluid (CSF) or plasma might be mediators of the psychophysiological mechanisms relating a history of trauma exposure to changes in behavior and mental health disorders, and medical morbidity. Here we test the cytokine/chemokine hypothesis for PTSD by examining levels of 17 classical cytokines and chemokines in CSF, sampled at 0900 hours, and in plasma sampled hourly for 24 h...
February 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28027046/factors-associated-with-success-in-an-occupational-rehabilitation-program-for-work-related-musculoskeletal-disorders
#3
Mark E Hardison, Shawn C Roll
Work-related musculoskeletal disorders are a significant burden; however, no consensus has been reached on how to maximize occupational rehabilitation programs for people with these disorders, and the impact of simulating work tasks as a mode of intervention has not been well examined. In this retrospective cohort study, the authors used logistic regression to identify client and program factors predicting success for 95 clients in a general occupational rehabilitation program and 71 clients in a comprehensive occupational rehabilitation program...
January 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/27883317/somatoform-disorders-a-pediatric-experience
#4
Nada Pop-Jordanova, Tatjana Zorcec
Somatization in children consists of the persistent experience and complaints of somatic distress that cannot be fully explained by a medical diagnosis. Working at the Psychophysiological Department at the University Clinic we are dealing with more than 100 children per year manifesting this kind of disorders. The aim of this article is to summarize some specific characteristics of the somatoform disorder in a group of 243 children, mean age 10.31 (± 2.75) years for both genders, selected randomly. The used psychometric instruments are: CBCL, EPQ for children, and MMPI-201 for mothers...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27882412/impact-of-attention-deficit-hyperactivity-disorder-therapy-on-fracture-risk-in-children-treated-in-german-pediatric-practices
#5
L Jacob, K Kostev
: Two thousand eight hundred ninety-four children and adolescents treated by 243 pediatricians were analyzed. Patients receiving attention deficit hyperactivity disorder (ADHD) medications were at a lower risk of fractures than patients without ADHD medications. The strongest impact was in the age group of 6-9 years. Finally, there was a significant association between therapy duration and fracture risk. INTRODUCTION: The aim of this study was to analyze the impact of ADHD therapy on fracture risk in children treated by German pediatricians...
November 24, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27843072/toward-a-more-evidence-based-nosology-and-nomenclature-for-female-sexual-dysfunctions-part-ii
#6
Sharon J Parish, Andrew T Goldstein, Sue W Goldstein, Irwin Goldstein, James Pfaus, Anita H Clayton, Annamaria Giraldi, James A Simon, Stanley E Althof, Gloria Bachmann, Barry Komisaruk, Roy Levin, Susan Kellogg Spadt, Sheryl A Kingsberg, Michael A Perelman, Marcel D Waldinger, Beverly Whipple
INTRODUCTION: Current Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) definitions of sexual dysfunction do not identify all sexual problems experienced clinically by women and are not necessarily applicable for biologic or biopsychosocial management of female sexual dysfunction. A unified nomenclature system enables clinicians, researchers, and regulatory agencies to use the same language and criteria for determining clinical end points, assessing research results, and managing patients...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27822663/effectiveness-of-a-cognitive-behavioral-therapy-based-indicated-prevention-program-for-children-with-elevated-anxiety-levels-a-randomized-controlled-trial
#7
Manon L A van Starrenburg, Rowella C M W Kuijpers, Marloes Kleinjan, Giel J M Hutschemaekers, Rutger C M E Engels
Childhood anxiety is a problem not only because of its negative consequences on the well-being of children but also because of its adverse effects on society and its role in mental disorders later in life. Adequate prevention might be the key in tackling this problem. The effectiveness of Coping Cat, as an indicated CBT-based prevention program in Dutch primary school children, was assessed by means of a randomized controlled trial. In total, 141 children aged 7-13 with elevated levels of anxiety and their mothers were included and randomly assigned to an intervention group and a waiting list control group...
January 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27647710/measuring-affiliation-in-group-therapy-for-substance-use-disorders-in-the-women-s-recovery-group-study-does-it-matter-whether-the-group-is-all-women-or-mixed-gender
#8
Dawn E Sugarman, Sara B Wigderson, Brittany R Iles, Julia S Kaufman, Garrett M Fitzmaurice, E Yvette Hilario, Michael S Robbins, Shelly F Greenfield
BACKGROUND AND OBJECTIVES: A Stage II, two-site randomized clinical trial compared the manualized, single-gender Women's Recovery Group (WRG) to mixed-gender group therapy (Group Drug Counseling; GDC) and demonstrated efficacy. Enhanced affiliation and support in the WRG is a hypothesized mechanism of efficacy. This study sought to extend results of the previous small Stage I trial that showed the rate of supportive affiliative statements occurred more frequently in WRG than GDC. METHODS: Participants (N = 158; 100 women, 58 men) were 18 years or older, substance dependent, and had used substances within the past 60 days...
October 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/27642271/metabolomics-enables-precision-medicine-a-white-paper-community-perspective
#9
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27641503/a-cortical-circuit-for-sexually-dimorphic-oxytocin-dependent-anxiety-behaviors
#10
Kun Li, Miho Nakajima, Ines Ibañez-Tallon, Nathaniel Heintz
The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female sociosexual behavior. Here, we show that, in male mice, OxtrINs regulate anxiety-related behaviors. We demonstrate that corticotropin-releasing-hormone-binding protein (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs. Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyramidal cell activity of male, but not female, mice, thus producing an anxiolytic effect...
September 22, 2016: Cell
https://www.readbyqxmd.com/read/27635438/2-methyl-6-phenylethynyl-pyridine-hydrochloride-modulates-metabotropic-glutamate-5-receptors-endogenously-expressed-in-zebrafish-brain
#11
José Luis Albasanz, Soraya Santana, Fernando Guzman-Sanchez, David León, Javier S Burgos, Mairena Martín
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer's disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from AD patients. Metabotropic glutamate 5 (mGlu5) receptors are G-protein coupled receptors proposed as potential targets for therapy of different neurodegenerative disorders. Thus, MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride), a selective noncompetitive mGlu5 receptor antagonist, has been suggested for pharmacological treatment of AD...
December 21, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27576727/long-term-treatment-with-enzyme-replacement-therapy-in-patients-with-fabry-disease
#12
Daniel Oder, Peter Nordbeck, Christoph Wanner
Anderson-Fabry disease is a potentially life-threatening hereditary lysosomal storage disorder taking origin in over 1,000 known pathogenic mutations in the alpha-galactosidase A encoding gene. Over the past 15 years, intravenous replacement therapy of the deficient alpha agalsidase A enzyme has been well-established retarding the progression of a multisystemic disease and organ involvement. Despite this innovative treatment approach, premature deaths still do occur. The response to enzyme replacement therapy (ERT) varies considerably and appears to depend on gender, genotype (classic or later onset/non-classic), stage of disease or age and agalsidase inhibition by anti-agalsidase antibodies...
2016: Nephron
https://www.readbyqxmd.com/read/27490457/a-structural-mri-study-in-transgender-persons-on-cross-sex-hormone-therapy
#13
Sven C Mueller, Lionel Landré, Katrien Wierckx, Guy T'Sjoen
BACKGROUND: To date, research findings are inconsistent about whether neuroanatomy in transgender persons resembles that of their natal sex or their gender identity. Moreover, few studies have examined the effects of long-term, cross-sex hormonal treatment on neuroanatomy in this cohort. The purpose of the present study was to examine neuroanatomical differences in transgender persons after prolonged cross-sex hormone therapy. METHODS: Eighteen transgender men (female-to-male), 17 transgender women (male-to-female), 30 non-transgender men (natal men), and 27 non-transgender women (natal women) completed a high-resolution structural MRI scan at 3Tesla...
August 5, 2016: Neuroendocrinology
https://www.readbyqxmd.com/read/27397062/the-role-of-gender-specific-cytokine-pathways-as-drug-targets-and-gender-specific-biomarkers-in-personalized-cancer-therapy
#14
Anna Maria Berghella, Ida Contasta, Roberto Lattanzio, Giancarlo Di Gregorio, Irma Campitelli, Silvino Marino, Luigi Liborio Liberatore, Luca Navarra, Giampaolo Caterino, Antonio Mongelli, Vincenzo Vittorini, Matteo Basta, Mauro Domenicucci, Nunzia Antonucci, Tiziana Del Beato, Enzo Secinaro, Fabiana Ciccone, Patrizia Pellegrini
The definition of personalized treatments in tumor disease could lead to an improvement of the therapeutic success rate. Therefore, biomarkers are urgently required in order to select the patients that could benefit from adjuvant therapies in the initial phase of the disease and to better define and treat the clinical/therapeutic subgroups in the advanced pathological phases. Disregulation of cytokine physiological network is directly involved in the genesis and progression of tumors. Cytokines are of central importance in the regulation of immune system, but they are rarely released singly: each cytokine is able to induce the production of many others factors leading to a network in which they cooperate with other cell regulators such as hormones and neuropeptides...
June 30, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27379002/semantic-verbal-fluency-in-children-with-and-without-autism-spectrum-disorder-relationship-with-chronological-age-and-iq
#15
Gemma Pastor-Cerezuela, Maria-Inmaculada Fernández-Andrés, Mireia Feo-Álvarez, Francisco González-Sala
We administered a semantic verbal fluency (SVF) task to two groups of children (age range from 5 to 8): 47 diagnosed with Autism Spectrum Disorder (ASD Group) and 53 with typical development (Comparison Group), matched on gender, chronological age, and non-verbal IQ. Four specific indexes were calculated from the SVF task, reflecting the different underlying cognitive strategies used: clustering (component of generativity and lexical-semantic access), and switching (executive component, cognitive flexibility)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27351435/-trends-in-pharmaceutical-care-for-men
#16
Gerd Glaeske
Over the past few years, perceptible changes - both fundamental and specific - have taken place in pharmaceutical care for men. While the most striking difference persists, namely that between somatic drug therapies for men and drugs for the treatment of psychological disorders and diseases, the large discrepancies that long existed between the quantities prescribed for men and women have meanwhile not only evened out, but men are even prescribed larger quantities than women if they undergo drug therapy. An analysis of the drugs prescribed particularly for men revealed that they are primarily prescribed for the treatment of cardiovascular diseases (hypertension and cardiac insufficiency) and metabolic disorders (diabetes, gout), especially in elderly patients...
August 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27344209/-not-available
#17
REVIEW
V Dinkelacker
INTRODUCTION: Drug-resistant epilepsy is a debilitating condition that warrants new therapeutic options. The last two decades have seen a growing interest in the relationship between epilepsy and obstructive sleep apnea syndrome (OSAS), which could ultimately yield non-pharmaceutical treatment strategies. Based on a Medline search of the literature, this review develops lines of evidence for a clinically significant role of OSAS in refractory epilepsy. STATE OF THE ART: OSAS is a primary sleep disorder that could presumably lower the seizure threshold via mechanisms such as sleep fragmentation, oxygen desaturation and chronic sleep deprivation...
June 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27275232/dietary-patterns-of-children-with-autism-spectrum-disorder-a-study-based-in-egypt
#18
Nagwa Meguid, Mona Anwar, Safaa Zaki, Wafaa Kandeel, Nihad Ahmed, Ihab Tewfik
AIM: In the hope to assist in tailoring individualized nutritional therapy, this study aimed to assess the nutritional status of autistic children. MATERIAL AND METHODS: This cross-sectional study included 80 autistic children, divided into two groups: group 1 (aged 3- 5 years) and group 2 (aged 6-9 years). Diagnosis was performed based on the criteria for autistic disorder as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Autism Diagnostic Interview Revised and Autism Rating Scale...
June 15, 2015: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27147973/catamenial-epilepsy-discovery-of-an-extrasynaptic-molecular-mechanism-for-targeted-therapy
#19
REVIEW
Doodipala Samba Reddy
Catamenial epilepsy is a type of refractory epilepsy characterized by seizure clusters around perimenstrual or periovulatory period. The pathophysiology of catamenial epilepsy still remains unclear, yet there are few animal models to study this gender-specific disorder. The pathophysiology of perimenstrual catamenial epilepsy involves the withdrawal of the progesterone-derived GABAergic neurosteroids due to the decline in progesterone level at the time of menstruation. These manifestations can be faithfully reproduced in rodents by specific neuroendocrine manipulations...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27099579/treatment-of-chronic-constipation-prescription-medications-and-surgical-therapies
#20
Zilla H Hussain, Kelly Everhart, Brian E Lacy
Constipation is a highly prevalent disorder that affects people regardless of age, race, gender, or socioeconomic status. For many patients, constipation is a chronic condition that reduces quality of life. Chronic constipation also imposes a significant economic burden on the health care system. The treatment of constipation remains problematic for both patients and providers for a variety of reasons, including a lack of specificity of symptoms, an inconsistent relationship between underlying pathophysiology and symptom generation, and different and unpredictable patient responses to medications...
February 2015: Gastroenterology & Hepatology
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